INVITAE CORP, 10-Q filed on 11/5/2020
Quarterly Report
v3.20.2
Cover Page - shares
 9 Months Ended
Sep. 30, 2020
Oct. 30, 2020
Cover [Abstract]    
Entity Registrant Name Invitae Corp  
Document Type 10-Q  
Document Period End Date Sep. 30, 2020  
Current Fiscal Year End Date --12-31  
Document Quarterly Report true  
Document Transition Report false  
Title of 12(b) Security Common Stock, $0.0001 par value per share  
Trading Symbol NVTA  
Security Exchange Name NYSE  
Entity Incorporation, State or Country Code DE  
Entity Central Index Key 0001501134  
Entity File Number 001-36847  
Amendment Flag false  
Entity Current Reporting Status Yes  
Entity Interactive Data Current Yes  
Entity Filer Category Large Accelerated Filer  
Entity Small Business false  
Entity Emerging Growth Company false  
Entity Shell Company false  
Entity Common Stock, Shares Outstanding   176,699,713
Document Fiscal Year Focus 2020  
Document Fiscal Period Focus Q3  
Entity Tax Identification Number 27-1701898  
Entity Address, Address Line One 1400 16th Street  
Entity Address, City or Town San Francisco  
Entity Address, State or Province CA  
Entity Address, Postal Zip Code 94103  
City Area Code 415  
Local Phone Number 374-7782  
v3.20.2
Condensed Consolidated Balance Sheets - USD ($)
$ in Thousands
Sep. 30, 2020
Dec. 31, 2019
Current assets:    
Cash and cash equivalents $ 106,436 $ 151,389
Marketable securities 254,848 240,436
Accounts receivable 27,328 32,541
Prepaid expenses and other current assets 26,492 18,032
Total current assets 415,104 442,398
Property and equipment, net 46,130 37,747
Operating lease assets 39,007 36,640
Restricted cash 6,685 6,183
Intangible assets, net 187,060 125,175
Goodwill 211,225 126,777
Other assets 7,961 6,681
Total assets 913,172 781,601
Current liabilities:    
Accounts payable 15,589 10,321
Accrued liabilities 77,986 64,814
Operating lease obligations 6,628 4,870
Finance lease obligations 1,237 1,855
Total current liabilities 101,440 81,860
Operating lease obligations, net of current portion 42,363 42,191
Finance lease obligations, net of current portion 1,834 1,155
Convertible senior notes, net 279,870 268,755
Deferred tax liability 10,250 0
Other long-term liabilities 60,864 8,000
Total liabilities 496,621 401,961
Commitments and contingencies (Note 8)
Stockholders’ equity:    
Common stock 13 10
Accumulated other comprehensive income (loss) 199 (9)
Additional paid-in capital 1,542,848 1,138,316
Accumulated deficit (1,126,509) (758,677)
Total stockholders’ equity 416,551 379,640
Total liabilities and stockholders’ equity $ 913,172 $ 781,601
v3.20.2
Condensed Consolidated Statements of Operations - USD ($)
shares in Thousands, $ in Thousands
 3 Months Ended 9 Months Ended
Sep. 30, 2020
Sep. 30, 2019
Sep. 30, 2020
Sep. 30, 2019
Revenue:        
Total revenue $ 68,728 $ 56,511 $ 179,167 $ 150,539
Cost of revenue 46,643 32,120 130,017 81,380
Research and development 37,802 46,951 168,433 90,247
Selling and marketing 37,800 32,690 119,440 87,662
General and administrative 27,306 21,733 81,966 56,326
Loss from operations (80,823) (76,983) (320,689) (165,076)
Other expense, net (15,771) (7,591) (32,499) (5,572)
Interest expense (6,308) (2,833) (17,244) (7,062)
Net loss before taxes (102,902) (87,407) (370,432) (177,710)
Income tax benefit 0 (8,700) (2,600) (12,650)
Net loss $ (102,902) $ (78,707) $ (367,832) $ (165,060)
Net loss per share, basic and diluted (in dollars per share) $ (0.78) $ (0.82) $ (3.08) $ (1.86)
Shares used in computing net loss per share, basic and diluted 132,484 95,577 119,386 88,663
Test revenue        
Revenue:        
Total revenue $ 67,326 $ 55,502 $ 175,503 $ 147,423
Other revenue        
Revenue:        
Total revenue $ 1,402 $ 1,009 $ 3,664 $ 3,116
v3.20.2
Condensed Consolidated Statements of Comprehensive Loss - USD ($)
$ in Thousands
 3 Months Ended 9 Months Ended
Sep. 30, 2020
Sep. 30, 2019
Sep. 30, 2020
Sep. 30, 2019
Statement of Comprehensive Income [Abstract]        
Net loss $ (102,902) $ (78,707) $ (367,832) $ (165,060)
Other comprehensive income (loss):        
Unrealized income (loss) on available-for-sale marketable securities, net of tax (373) 0 208 5
Comprehensive loss $ (103,275) $ (78,707) $ (367,624) $ (165,055)
v3.20.2
Condensed Consolidated Statements of Stockholders' Equity - USD ($)
$ in Thousands
Total
Common stock:
Accumulated other comprehensive income (loss):
Additional paid-in capital:
Accumulated deficit:
Restatement adjustment
Additional paid-in capital:
Balance, beginning of period at Dec. 31, 2018   $ 8 $ (5) $ 678,548 $ (516,712)  
Increase (Decrease) in Stockholders' Equity [Roll Forward]            
Common stock issued   2   204,024    
Unrealized income (loss) on available-for-sale marketable securities, net of tax $ 5   5      
Common stock issued on exercise of stock options, net       2,985    
Common stock issued pursuant to exercises of warrants       171    
Common stock issued pursuant to employee stock purchase plan       2,578    
Common stock issued or issuable pursuant to business combinations       95,220    
Equity component of convertible senior notes, net       75,488    
Stock-based compensation expense       26,629    
Net loss (165,060)          
Balance, end of period at Sep. 30, 2019 403,881 10 0 1,085,643 (681,772)  
Balance, beginning of period at Jun. 30, 2019   9 0 944,559 (603,065)  
Increase (Decrease) in Stockholders' Equity [Roll Forward]            
Common stock issued   1   19,534    
Unrealized income (loss) on available-for-sale marketable securities, net of tax 0          
Common stock issued on exercise of stock options, net       553    
Common stock issued pursuant to exercises of warrants       58    
Common stock issued or issuable pursuant to business combinations       35,778    
Equity component of convertible senior notes, net       75,488    
Stock-based compensation expense       9,673    
Net loss (78,707)       (78,707)  
Balance, end of period at Sep. 30, 2019 403,881 10 0 1,085,643 (681,772)  
Balance, beginning of period at Dec. 31, 2019 379,640 10 (9) 1,138,316 (758,677)  
Balance, beginning of period (Immaterial error related to classification of Indemnification from acquisition) at Dec. 31, 2019           $ (10,387)
Increase (Decrease) in Stockholders' Equity [Roll Forward]            
Common stock issued   3   217,486    
Unrealized income (loss) on available-for-sale marketable securities, net of tax 208   208      
Common stock issued on exercise of stock options, net       4,163    
Common stock issued pursuant to exercises of warrants       386    
Common stock issued pursuant to employee stock purchase plan       4,527    
Common stock issued or issuable pursuant to business combinations       134,445    
Stock-based compensation expense       53,912    
Net loss (367,832)          
Balance, end of period at Sep. 30, 2020 416,551 13 199 1,542,848 (1,126,509)  
Balance, beginning of period at Jun. 30, 2020   13 572 1,487,217 (1,023,607)  
Increase (Decrease) in Stockholders' Equity [Roll Forward]            
Unrealized income (loss) on available-for-sale marketable securities, net of tax (373)   (373)      
Common stock issued on exercise of stock options, net       1,992    
Common stock issued pursuant to exercises of warrants       324    
Common stock issued or issuable pursuant to business combinations       31,939    
Stock-based compensation expense       21,376    
Net loss (102,902)       (102,902)  
Balance, end of period at Sep. 30, 2020 $ 416,551 $ 13 $ 199 $ 1,542,848 $ (1,126,509)  
v3.20.2
Condensed Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
 9 Months Ended
Sep. 30, 2020
Sep. 30, 2019
Cash flows from operating activities:    
Net loss $ (367,832) $ (165,060)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 22,964 11,135
Stock-based compensation 102,329 47,826
Amortization of debt discount and issuance costs 11,115 855
Remeasurements of liabilities associated with business combinations 42,448 0
Benefit from income taxes (2,600) (12,650)
Debt extinguishment costs 0 8,926
Other (570) 901
Changes in operating assets and liabilities, net of businesses acquired:    
Accounts receivable 5,516 (444)
Prepaid expenses and other current assets (8,460) (1,424)
Other assets 1,387 2,369
Accounts payable 3,118 87
Accrued expenses and other liabilities 5,665 9,692
Net cash used in operating activities (184,920) (97,787)
Cash flows from investing activities:    
Purchases of marketable securities (180,021) (20,781)
Proceeds from sales of marketable securities 12,832 0
Proceeds from maturities of marketable securities 152,465 34,500
Acquisition of businesses, net of cash acquired (57,576) (9,801)
Purchases of property and equipment (13,991) (13,530)
Other (2,000) 0
Net cash used in investing activities (88,291) (9,612)
Cash flows from financing activities:    
Proceeds from public offerings of common stock, net 217,489 204,024
Proceeds from issuance of common stock, net 9,076 5,734
Proceeds from issuance of convertible senior notes, net 0 339,900
Payments of debt extinguishment costs 0 (10,638)
Loan payments 0 (75,000)
Finance lease principal payments (1,543) (1,590)
Other 3,738 0
Net cash provided by financing activities 228,760 462,430
Net increase (decrease) in cash, cash equivalents and restricted cash (44,451) 355,031
Cash, cash equivalents and restricted cash at beginning of period 157,572 118,164
Cash, cash equivalents and restricted cash at end of period 113,121 473,195
Supplemental cash flow information of non-cash investing and financing activities:    
Equipment acquired through finance leases 1,971 0
Purchases of property and equipment in accounts payable and accrued liabilities 3,576 1,339
Common stock issued for acquisition of businesses 82,185 104,801
Operating lease assets obtained in exchange for lease obligations, net $ 6,157 $ 5,615
v3.20.2
Organization and description of business
 9 Months Ended
Sep. 30, 2020
Organization, Consolidation and Presentation of Financial Statements [Abstract]  
Organization and description of business Organization and description of business
Invitae Corporation ("Invitae," “the Company," "we," "us," and "our") was incorporated in the State of Delaware on January 13, 2010, as Locus Development, Inc. and changed its name to Invitae Corporation in 2012. We utilize an integrated portfolio of laboratory processes, software tools and informatics capabilities to process DNA-containing samples, analyze information about patient-specific genetic variation and generate test reports for clinicians and patients. Our main production facility is located in San Francisco, California. We currently have more than 20,000 genes in production and provide a variety of diagnostic tests that can be used in multiple indications. We offer genetic testing across multiple clinical areas, including hereditary cancer, cardiology, neurology, pediatrics, metabolic conditions and rare diseases. To augment our offering and realize our mission, we acquired multiple assets including four businesses in 2017, which expanded our suite of genome management offerings and expanded our offering in reproductive health. In the first quarter of 2019, we introduced our non-invasive prenatal screen ("NIPS"). In June 2019, we launched a direct channel to consumers to increase accessibility to our testing platform. To improve our technology stack and reduce costs associated with variant interpretation, we acquired Singular Bio, Inc. ("Singular Bio") in June 2019, Jungla Inc. ("Jungla") in July 2019, and Oracle BV operating under the name "Diploid" in March 2020. To further expand our ability to scale and improve customer experience with patient support telehealth solutions and the use of chatbots, we acquired Clear Genetics, Inc. ("Clear Genetics") in November 2019. In April 2020, we acquired YouScript Incorporated ("YouScript") and Genelex Solutions, LLC ("Genelex") to expand content and improve customer experience by bringing pharmacogenetic testing and integrated clinical decision support to Invitae. In order to expand content and increase access to personalized oncology, in October 2020 we acquired ArcherDX, Inc. ("ArcherDX"), with a view towards integrating Invitae's germline testing with ArcherDX's tumor profiling and liquid biopsy technology and services into a single platform to enable precision medicine approaches from diagnostic testing to therapy optimization and monitoring. As of September 30, 2020, Invitae operates in one segment.
Basis of presentation
The accompanying unaudited condensed consolidated financial statements have been prepared in accordance with U.S. generally accepted accounting principles (“U.S. GAAP”) for interim financial information and in accordance with the instructions to Form 10-Q and Rule 10-01 of Regulation S-X. Accordingly, they do not include all of the information and footnotes required by generally accepted accounting principles for complete financial statements. The unaudited interim condensed consolidated financial statements have been prepared on the same basis as the annual financial statements. In the opinion of management, the accompanying unaudited condensed consolidated financial statements reflect all adjustments (consisting only of normal recurring adjustments) considered necessary for a fair presentation. The information included in this Quarterly Report on Form 10-Q should be read in conjunction with the audited financial statements and notes thereto included in our Annual Report on Form 10-K for the year ended December 31, 2019. The results for the three and nine months ended September 30, 2020 are not necessarily indicative of the results expected for the full fiscal year or any other periods.
v3.20.2
Summary of significant accounting policies
 9 Months Ended
Sep. 30, 2020
Accounting Policies [Abstract]  
Summary of significant accounting policies Summary of significant accounting policies
Principles of consolidation
Our unaudited condensed consolidated financial statements include our accounts and the accounts of our wholly-owned subsidiaries. All intercompany balances and transactions have been eliminated in consolidation.
Use of estimates
The preparation of financial statements in conformity with U.S. GAAP requires management to make judgments, estimates and assumptions that affect the reported amounts of assets and liabilities and disclosure of contingent liabilities as of the date of the financial statements and the reported amounts of revenue and expenses during the reporting period. We base these estimates on current facts, historical and anticipated results, trends and various other assumptions that we believe are reasonable under the circumstances, including assumptions as to future events. Actual results could differ materially from those judgments, estimates and assumptions. We evaluate our estimates on an ongoing basis.
Concentrations of credit risk and other risks and uncertainties
Financial instruments that potentially subject us to a concentration of credit risk consist of cash, cash equivalents, marketable securities and accounts receivable. Our cash and cash equivalents are primarily held by financial institutions in the United States. Such deposits may exceed federally insured limits.
Significant customers are those that represent 10% or more of our total revenue presented on the consolidated statements of operations. Our revenue from significant customers as a percentage of our total revenue was as follows:
 
 
Three Months Ended September 30,
 
Nine Months Ended September 30,
 
 
2020
 
2019
 
2020
 
2019
Medicare
 
20
%
 
27
%
 
20
%
 
23
%

Cash, cash equivalents and restricted cash
The following table provides a reconciliation of cash, cash equivalents and restricted cash reported within the consolidated balance sheets that sum to the total of the same amounts shown in the statements of cash flows (in thousands):
 
September 30,
2020
 
December 31,
2019
Cash and cash equivalents
$
106,436

 
$
151,389

Restricted cash
6,685

 
6,183

Total cash, cash equivalents and restricted cash
$
113,121

 
$
157,572


Inventory
We maintain test reagents and other consumables primarily used in sample collection kits which are valued at the lower of cost or net realizable value. Cost is determined using actual costs on a first-in, first-out basis. Our inventory was $14.9 million and $6.6 million as of September 30, 2020 and December 31, 2019, respectively, and was recorded in prepaid expenses and other current assets on our consolidated balance sheets. While we have not experienced significant disruption in our supply chain and we do not yet know the full impact COVID-19 will have on our supply chain, we have increased our inventory on hand to respond to potential future disruptions that may occur.
Fair value of financial instruments
Our financial instruments consist principally of cash and cash equivalents, marketable securities, accounts payable, accrued liabilities, finance leases and liabilities associated with business combinations. The carrying amounts of certain of these financial instruments, including cash and cash equivalents, accounts receivable, accounts payable and accrued and other current liabilities approximate their current fair value due to the relatively short-term nature of these accounts. Based on borrowing rates available to us, the carrying value of our finance leases approximate their fair values. Liabilities associated with business combinations are recorded at their estimated fair value.
Prior period reclassifications
We have reclassified certain amounts in prior periods to conform with current presentation.
Immaterial correction of an error
We determined the historical classification of certain acquisition-related obligations as equity and the subsequent measurement of such obligations was inappropriate and instead should have been classified as liabilities and subsequently measured at fair value with changes recognized in other income (expense), net during the three months ended March 31, 2020. We determined that the impact of the error to previously issued financial statements was not material and have corrected the immaterial error in the three months ended March 31, 2020. The impact of this correction was an increase to other long-term liabilities of $10.1 million, a corresponding decrease to additional paid-in capital of $10.4 million and an increase to other income, net of $0.3 million.
Recent accounting pronouncements
We evaluate all Accounting Standards Updates (“ASUs”) issued by the Financial Accounting Standards Board ("FASB") for consideration of their applicability. ASUs not included in the disclosures in this report were assessed and determined to be either not applicable or are not expected to have a material impact on our consolidated financial statements.
In August 2020, the FASB issued ASU No. 2020-06, Accounting for Convertible Instruments and Contracts in an Entity's Own Equity, which simplifies the accounting for certain convertible instruments, amends the guidance on derivative scope exceptions for contracts in an entity's own equity, and modifies the guidance on diluted earnings per share calculations as a result of these changes. This new standard is effective for our interim and annual periods beginning January 1, 2022, and earlier adoption is permitted. We may elect to apply the amendments on a retrospective or modified retrospective basis. We are currently evaluating the impact of the adoption of this standard on our condensed consolidated financial statements.
Recently adopted accounting pronouncements
In June 2016, the FASB issued ASU 2016-13, Financial Instruments-Credit Losses (Topic 326), which requires measurement and recognition of expected credit losses for financial assets. This guidance became effective for us beginning in the first quarter of 2020 and was adopted using a modified retrospective approach, with certain exceptions. The adoption of Topic 326 did not have a material impact on our consolidated financial statements as credit losses are not expected to be significant.
As part of our adoption of Topic 326, we assess our accounts receivables for expected credit losses at each reporting period by disaggregating by payer type and further by portfolios of customers with similar characteristics, such as customer type and geographic location. We then review each portfolio for expected credit losses based on historical payment trends as well as forward looking data and current economic trends. If a credit loss is determined, we record a reduction to our accounts receivable balance with a corresponding general and administrative expense.
In accordance with Topic 326, we no longer evaluate whether our available-for-sale debt securities in an unrealized loss position are other than temporarily impaired. Instead, we assess whether such unrealized loss positions are credit-related. Our expected loss allowance methodology for these securities is developed by reviewing the extent of the unrealized loss, the issuers’ credit ratings and any changes in those ratings, as well as reviewing current and future economic market conditions and the issuers’ current status and financial condition. The credit-related portion of unrealized losses, and any subsequent improvements, are recorded in other income (expense), net. Unrealized gains and losses that are not credit-related are included in accumulated other comprehensive income (loss).
v3.20.2
Revenue, accounts receivable and deferred revenue
 9 Months Ended
Sep. 30, 2020
Revenue from Contract with Customer [Abstract]  
Revenue, accounts receivable and deferred revenue Revenue, accounts receivable and deferred revenue
Test revenue is generated from sales of diagnostic tests to three groups of customers: institutions, such as hospitals, clinics and partners; patients who pay directly; and patients’ insurance carriers. Amounts billed and collected, and the timing of collections, vary based on whether the payer is an institution, a patient or an insurance carrier. Other revenue consists principally of revenue recognized under collaboration and genome network agreements and is accounted for under the provisions provided in Accounting Standards Codification ("ASC") 606, Revenue from Contracts with Customers.
The following table includes our revenues as disaggregated by payer category (in thousands):
 
Three Months Ended September 30,
 
Nine Months Ended September 30,
 
2020
 
2019
 
2020
 
2019
Test revenue:
 
 
 
 
 
 
 
Institutions
$
14,015

 
$
10,407

 
$
37,043

 
$
28,375

Patient - direct
6,379

 
4,567

 
16,468

 
12,364

Patient - insurance
46,932

 
40,528

 
121,992

 
106,684

Total test revenue
67,326

 
55,502

 
175,503

 
147,423

Other revenue
1,402

 
1,009

 
3,664

 
3,116

Total revenue
$
68,728

 
$
56,511

 
$
179,167

 
$
150,539


We recognize revenue related to billings based on estimates of the amount that will ultimately be realized. Cash collections for certain diagnostic tests delivered may differ from rates originally estimated. As a result of new information, we update our estimates quarterly of the amounts to be recognized for previously delivered tests which resulted in the following increases to revenue and decreases to our loss from operations and basic and diluted net loss per share (in millions, except per share amounts):
 
Three Months Ended September 30,
 
Nine Months Ended September 30,
 
2020
 
2019
 
2020
 
2019
Revenue
$
0.7

 
$
1.2

 
$
3.0

 
$
4.0

Loss from operations
$
(0.7
)
 
$
(1.2
)
 
$
(3.0
)
 
$
(4.0
)
Net loss per share, basic and diluted
$
(0.01
)
 
$
(0.01
)
 
$
(0.03
)
 
$
(0.05
)

Influence of COVID-19
Our test volumes decreased significantly in the second half of March 2020 as compared to the first few months of 2020 as a result of COVID-19 and related limitations and priorities across the healthcare system. Our daily test volumes have consistently increased from the low in March 2020, although we are currently still experiencing changes in product mix due to the impact of COVID-19. COVID-19 could have a material impact on our financial results for at least the next quarter and for the foreseeable future, particularly on product mix and as a result, the revenue we recognize. We have reviewed and adjusted for the impact of COVID-19 on our estimates related to revenue recognition and expected credit losses.
Approximately 8% of our workforce as of March 31, 2020 was impacted by a reduction in force in April 2020 in an initiative to manage costs and cash burn that resulted in one-time costs in the second quarter of 2020 of $3.8 million. In addition, effective May 2020, we have reduced the salaries of our named executive officers by approximately 20%.
On March 27, 2020, the Coronavirus Aid, Relief, and Economic Security Act ("CARES Act") was signed into law which was a stimulus bill intended to bolster the economy, among other things, and provide assistance to qualifying businesses and individuals. The CARES Act included an infusion of funds into the healthcare system, and in April 2020, we received $3.8 million as a part of this initiative. This payment was recognized as other income (expense), net in our consolidated statement of operations during the three months ended June 30, 2020. At this time, we are not certain of the availability, extent or impact of any future relief provided under the CARES Act.
Accounts receivable
The majority of our accounts receivable represents amounts billed to institutions (e.g., hospitals, clinics, partners) and estimated amounts to be collected from third-party insurance payers for diagnostic test revenue recognized. Also included are amounts due under the terms of collaboration and genome network agreements for diagnostic testing and data aggregation reporting services provided and proprietary platform access rights transferred.
Deferred revenue
We record deferred revenue when cash payments are received or due in advance of our performance related to one or more performance obligations. The amounts deferred to date primarily consist of prepayments related to our consumer direct channel as well as consideration received pertaining to the estimated exercise of certain re-requisition rights. In order to comply with loss contract rules, our re-requisition rights revenue deferral is no less than the estimated cost of fulfilling related obligations. We recognize revenue related to re-requisition rights as the rights are exercised or expire unexercised, which is generally within 90 days of initial deferral.
v3.20.2
Business combinations
 9 Months Ended
Sep. 30, 2020
Business Combinations [Abstract]  
Business combinations Business combinations
Singular Bio
In June 2019, we acquired 100% of the fully diluted equity of Singular Bio, a privately held company developing single molecule detection technology, for approximately $57.3 million, comprised of $53.9 million in the form of 2.5 million shares of our common stock and the remainder in cash.
We granted approximately $90.0 million of restricted stock units ("RSU") under our 2015 Stock Incentive Plan as inducement awards to new employees who joined Invitae in connection with our acquisition of Singular Bio. $45.0 million of the RSUs are time-based and vest in three equal installments in December 2019, June 2020, and December 2020, subject to the employee's continued service with us ("Time-based RSUs") and $45.0 million of the RSUs are performance-based RSUs ("PRSUs") that vest upon the achievement of certain performance conditions. Since the number of awards granted is based on a 30-day volume weighted-average share price with a fixed dollar value, these Time-based RSUs and PRSUs are liability-classified and the fair value is estimated at each reporting period based on the number of shares that are expected to be issued at each reporting date and our closing stock price, which combined are categorized as Level 3 inputs. Therefore, fair value of the RSUs and PRSUs and the number of shares to be issued will not be fixed until the awards vest.
During the three and nine months ended September 30, 2020, we recorded research and development stock-based compensation expense of $6.3 million and $24.9 million, respectively, related to the Time-based RSUs, and $6.5 million of income and $23.6 million of expense, respectively, related to the PRSUs based on our evaluations of the probability of achieving performance conditions. During the three and nine months ended September 30, 2019, we recorded research and development stock-based compensation expense of $6.7 million and $7.6 million, respectively, related to the Time-based RSUs and $11.9 million and $13.6 million, respectively, related to the PRSUs. As of September 30, 2020, the Time-based RSUs and PRSUs had a total fair value of $46.5 million and $37.4 million, respectively, based on a total estimated issuance of 3.7 million shares and expectation of the achievement of the performance conditions. As of September 30, 2020, 1.7 million of the Time-based RSUs and 1.2 million of the PRSUs had vested with a total fair value of $60.9 million which was recorded in common stock issued or issuable pursuant to business combinations in the consolidated statements of stockholders' equity.
Jungla
In July 2019, we acquired 100% of the equity interest of Jungla, a privately held company developing a platform for molecular evidence testing in genes, for approximately $59.0 million, comprised of $44.9 million in the form of shares of our common stock and the remainder in cash.
We may be required to pay contingent consideration based on achievement of post-closing development milestones. As of the acquisition date, the fair value of this contingent consideration was $10.7 million including cash and common stock. These milestones are expected to be completed within two years of the date of acquisition, one of which was completed during the three months ended September 30, 2020. The material factors that may impact the fair value of the contingent consideration, and therefore, this liability, are the probabilities and timing of achieving the related milestones and the discount rate we used to estimate the fair value. Significant changes in any of the probabilities of success would result in a significant change in the fair value, which will be estimated at each reporting date with changes reflected as a general and administrative expense.
Upon acquisition, we had a stock payable liability related to our acquisition of Jungla which represents the hold-back obligation to issue 0.2 million shares subject to indemnification claims that may arise. This liability was adjusted at each reporting period based on the fair value of our common stock, which is a Level 3 input, with the change recorded in other income (expense), net. During July 2020, the hold-back shares were remitted in full to the former owners of Jungla.
Clear Genetics
In November 2019, we acquired 100% of the equity interest of Clear Genetics, a developer of software for providing genetic services at scale, for approximately $50.1 million. Of the cash and stock purchase price consideration issued, $0.2 million of cash and approximately 0.4 million shares of our common stock were subject to a 12-month hold back to satisfy indemnification obligations that may arise, 0.1 million of which were released during the three months ended June 30, 2020.
As of September 30, 2020, we had a stock payable liability related to our acquisition of Clear Genetics of $12.2 million which represents the hold-back obligation to issue 0.3 million shares subject to indemnification claims that may arise. This liability is adjusted at each reporting period based on the fair value of our common stock, which is a Level 3 input, with the change recorded in other income (expense), net.
Diploid
In March 2020, we acquired 100% of the equity interest of Diploid, a developer of artificial intelligence software capable of diagnosing genetic disorders using sequencing data and patient information, for approximately $82.3 million in cash and shares of our common stock. Of the stock purchase price consideration issued, approximately 0.4 million shares are subject to a hold-back to satisfy indemnification obligations that may arise. We included the financial results of Diploid in our consolidated financial statements from the acquisition date, which were not material for the nine months ended September 30, 2020.
The following table summarizes the purchase price recorded as a part of the acquisition of Diploid (in thousands):
 
Purchase Price
Cash transferred
$
32,323

Hold-back consideration - common stock
7,538

Common stock transferred
42,453

Total
$
82,314


Assets acquired and liabilities assumed are recorded based on valuations derived from estimated fair value assessments and assumptions used by us. While we believe that our estimates and assumptions underlying the valuations are reasonable, different estimates and assumptions could result in different valuations assigned to the individual assets acquired and liabilities assumed, and the resulting amount of goodwill. The following table summarizes the fair values of assets acquired and liabilities assumed through our acquisition of Diploid at the date of acquisition (in thousands):
Cash
$
124

Accounts receivable
26

Developed technology
41,789

Total identifiable assets acquired
41,939

Accounts payable
(30
)
Deferred tax liability
(10,250
)
Net identifiable assets acquired
31,659

Goodwill
50,655

Total purchase price
$
82,314


Based on the guidance provided in ASC 805, Business Combinations, we accounted for the acquisition of Diploid as a business combination in which we determined that 1) Diploid was a business which combines inputs and processes to create outputs, and 2) substantially all of the fair value of gross assets acquired was not concentrated in a single identifiable asset or group of similar identifiable assets.
Our purchase price allocation for the acquisition is preliminary and subject to revision as additional information about fair value of assets and liabilities becomes available, primarily related to our deferred tax liability assumed in connection with the acquisition. Additional information that existed as of the acquisition date but at the time was unknown to us may become known to us during the remainder of the measurement period, a period not to exceed 12 months from the acquisition date.
We measured the identifiable assets and liabilities assumed at their acquisition date fair values separately from goodwill. The intangible asset acquired is developed technology related to Diploid's artificial intelligence technology platform. The fair value of the developed technology was estimated using an income approach with an estimated useful life of nine years. As of the acquisition date, we recorded a stock payable liability of $7.5 million to represent the hold-back obligation to issue 0.4 million shares subject to indemnification claims that may arise. This liability is adjusted at each reporting period based on the fair value of our common stock, which is a Level 3 input. As of September 30, 2020, the value of this liability was $18.3 million with the change recorded in other expense, net.
Goodwill represents the excess of the purchase price over the fair value of the net tangible and intangible assets acquired. The acquisition of Diploid resulted in the recognition of $50.7 million of goodwill which we believe relates primarily to expansion of the acquired technology to apply to new areas of genetic testing. Goodwill created as a result of the acquisition of Diploid is not deductible for tax purposes.
In June 2020, we granted 0.2 million RSUs with a fair value of $3.6 million under our 2015 Stock Incentive Plan as inducement awards in connection with our acquisition of Diploid. These RSUs vest in two equal installments, in April 2021 and April 2022. The value of the awards was recognized as research and development stock-based compensation upon grant in June 2020 as there were no ongoing obligations required by the award recipients.
Genelex and YouScript
In April 2020, we acquired 100% of the equity interest of Genelex and YouScript to bring pharmacogenetic testing and integrated clinical decision support to Invitae. We acquired Genelex for approximately $13.2 million, primarily in shares of our common stock. Of the stock purchase price consideration issued, approximately 0.1 million shares are subject to a hold-back to satisfy indemnification obligations that may arise. We acquired YouScript for approximately $52.7 million, including cash consideration of $24.5 million and the remaining in shares of our common stock. Of the purchase price consideration for YouScript, approximately $1.4 million and 0.5 million shares of our common stock are subject to a hold-back to satisfy indemnification obligations that may arise. We included the financial results of Genelex and YouScript in our consolidated financial statements from the acquisition date, which were not material for the nine months ended September 30, 2020. We recorded $1.1 million of transaction costs related to the acquisition of Genelex and YouScript as general and administrative expense during the nine months ended September 30, 2020.
We may be required to pay contingent consideration in the form of additional shares of our common stock in connection with the acquisition of Genelex if, within a specified period following the closing, we achieve a certain product milestone, in which case we would issue shares of our common stock with a value equal to a portion of the gross revenues actually received by us for a pharmacogenetic product reimbursed through certain payers during an earn-out period of up to four years. As of the acquisition date, the fair value of this contingent consideration was $2.0 million in the form of shares of our common stock. The material factors that may impact the fair value of the contingent consideration, and therefore, this liability, are the probabilities and timing of achieving the related milestone, the estimated revenues achieved for a pharmacogenetic product and the discount rate we used to estimate the fair value. Significant changes in any of the probabilities of success would result in a significant change in the fair value, which is estimated at each reporting date with changes reflected as general and administrative expense.
The following table summarizes the purchase prices recorded as a part of the acquisition of Genelex and YouScript (in thousands):
 
Genelex
 
YouScript
 
Total
Cash transferred
$
972

 
$
24,462

 
$
25,434

Hold-back consideration - cash
—

 
1,385

 
1,385

Hold-back consideration - common stock
781

 
5,392

 
6,173

Contingent consideration
1,994

 
—

 
1,994

Common stock transferred
9,463

 
21,464

 
30,927

Total
$
13,210

 
$
52,703

 
$
65,913


Assets acquired and liabilities assumed are recorded based on valuations derived from estimated fair value assessments and assumptions used by us. While we believe that our estimates and assumptions underlying the valuations are reasonable, different estimates and assumptions could result in different valuations assigned to the individual assets acquired and liabilities assumed, and the resulting amount of goodwill. The following table summarizes the fair values of assets acquired and liabilities assumed through our acquisitions of Genelex and YouScript at the date of acquisition (in thousands):
 
Genelex
 
YouScript
 
Total
Cash
$
33

 
$
24

 
$
57

Accounts receivable
221

 
56

 
277

Prepaid expenses and other current assets
—

 
70

 
70

Operating lease assets
—

 
355

 
355

Developed technology
9,209

 
25,716

 
34,925

Total identifiable assets acquired
9,463

 
26,221

 
35,684

Current liabilities
(320
)
 
(481
)
 
(801
)
Deferred tax liability
—

 
(2,600
)
 
(2,600
)
Other long-term liabilities
—

 
(163
)
 
(163
)
Net identifiable assets acquired
9,143

 
22,977

 
32,120

Goodwill
4,067

 
29,726

 
33,793

Total purchase price
$
13,210

 
$
52,703

 
$
65,913


Based on the guidance provided in ASC 805, Business Combinations, we accounted for the acquisitions of Genelex and YouScript as business combinations in which we determined that 1) Genelex and YouScript were businesses which combine inputs and processes to create outputs, and 2) substantially all of the fair value of gross assets acquired were not concentrated in a single identifiable asset or group of similar identifiable assets.
Our purchase price allocation for the acquisitions is preliminary and subject to revision as additional information about fair value of assets and liabilities becomes available, primarily related to our deferred tax liability assumed. Additional information that existed as of the acquisition date but at the time was unknown to us may become known to us during the remainder of the measurement period, a period not to exceed 12 months from the acquisition date.
We measured the identifiable assets and liabilities assumed at their acquisition date fair values separately from goodwill. The intangible assets acquired are the developed technologies related to Genelex's and YouScript's technology platforms. The fair value of the developed technologies were estimated using an income approach with an estimated useful life of eight years. As of the acquisition date, we recorded stock payable liabilities of $6.2 million to represent the hold-back obligation to issue shares subject to indemnification claims that may arise. These liabilities are adjusted at each reporting period based on the fair value of our common stock, which is a Level 3 input. As of September 30, 2020, the value of this liability was $22.4 million with the change recorded in other income (expense), net.
Goodwill represents the excess of the purchase price over the fair value of the net tangible and intangible assets acquired. The acquisitions of Genelex and YouScript resulted in the recognition of $33.8 million of goodwill which we believe relates primarily to future functionality and expansion of the acquired technologies. Of the goodwill recognized, $29.7 million related to the YouScript acquisition is not deductible for tax purposes.
ArcherDX
In June 2020, we entered into a definitive agreement with ArcherDX, a genomics analysis company democratizing precision oncology, and in October 2020, the closing conditions were met and the transaction was consummated. Under the terms of the agreement, we acquired ArcherDX for upfront consideration consisting of 30.0 million shares of our common stock and $325.0 million in cash, plus up to an additional 27.0 million shares of our common stock payable in connection with the achievement of certain milestones.
In connection with the transaction with ArcherDX, we entered into a definitive agreement to sell $275.0 million in common stock in a private placement at a price of $16.85 per share. The private placement closed concurrently with the combination with ArcherDX. We received proceeds of $5.0 million from the private placement during September 2020 which are reflected as an accrued liability and classified as "Other" under cash flows from financing activities as of September 30, 2020; the remainder of the proceeds were received in October 2020. In addition, we borrowed $135.0 million on a senior secured term loan facility ("2020 Term Loan") concurrent with the closing of the ArcherDX transaction which bears interest at an annual rate equal to LIBOR, subject to a 2.00% LIBOR floor, plus a margin of 8.75%. The 2020 Term Loan will mature on (i) June 1, 2024 if at such time our 2.00% convertible senior notes due 2024 are outstanding and are due to mature on or prior to September 1, 2024, or (ii) otherwise, on June 1, 2025. In connection with the 2020 Term Loan, we issued warrants to purchase 1.0 million shares of our common stock with an exercise price of $16.85 per share. During October 2020, these warrants were exercised in full.
Given the timing of the closing of the transaction with ArcherDX, we are currently in the process of valuing the assets acquired and liabilities assumed. As a result, we are not yet able to provide the amounts to be recognized as of the acquisition date for the major classes of assets acquired and liabilities assumed and other related disclosures. We will disclose this and other related information in our Annual Report on Form 10-K for the year ending December 31, 2020.
v3.20.2
Goodwill and intangible assets
 9 Months Ended
Sep. 30, 2020
Goodwill and Intangible Assets Disclosure [Abstract]  
Goodwill and intangible assets Goodwill and intangible assets
Goodwill
The changes in the carrying amounts of goodwill were as follows (in thousands):
Balance as of December 31, 2019
 
$
126,777

Goodwill acquired - Diploid
 
50,655

Goodwill acquired - Genelex
 
4,067

Goodwill acquired - YouScript
 
29,726

Balance as of September 30, 2020
 
$
211,225


Intangible assets
The following table presents details of our intangible assets (in thousands):
 
September 30, 2020
 
December 31, 2019
 
Cost
 
Accumulated
Amortization
 
Net
 
Weighted-Average
Useful Life
(in Years)
 
Cost
 
Accumulated
Amortization
 
Net
 
Weighted-Average
Useful Life
(in Years)
Customer relationships
$
23,763

 
$
(7,241
)
 
$
16,522

 
10.0
 
$
23,763

 
$
(5,141
)
 
$
18,622

 
10.0
Developed technology
161,110

 
(21,038
)
 
140,072

 
8.6
 
84,396

 
(8,476
)
 
75,920

 
8.6
Non-compete agreement
286

 
(215
)
 
71

 
5.0
 
286

 
(172
)
 
114

 
5.0
Trade name
576

 
(570
)
 
6

 
2.7
 
576

 
(480
)
 
96

 
2.7
Patent licensing agreement
496

 
(95
)
 
401

 
15.0
 
496

 
(70
)
 
426

 
15.0
Favorable leases
247

 
(247
)
 
—

 
2.2
 
247

 
(238
)
 
9

 
2.2
In-process research and development
29,988

 
—

 
29,988

 
n/a
 
29,988

 
—

 
29,988

 
n/a
 
$
216,466

 
$
(29,406
)
 
$
187,060

 
8.8
 
$
139,752

 
$
(14,577
)
 
$
125,175

 
8.9


Acquisition-related intangibles included in the above table are finite-lived, other than in-process research and development which has an indefinite life, and are carried at cost less accumulated amortization. Customer relationships are being amortized on an accelerated basis, in proportion to estimated cash flows. All other finite-lived acquisition-related intangibles are being amortized on a straight-line basis over their estimated lives, which approximates the pattern in which the economic benefits of the intangible assets are realized. Amortization expense was $5.6 million and $2.2 million for the three months ended September 30, 2020 and 2019, respectively, and $14.8 million and $4.9 million for the nine months ended September 30, 2020 and 2019, respectively. Amortization expense is recorded to cost of revenue, research and development, sales and marketing and general and administrative expense.
The following table summarizes our estimated future amortization expense of intangible assets with finite lives as of September 30, 2020 (in thousands):
2020 (remainder of year)
$
5,597

2021
22,792

2022
21,087

2023
20,074

2024
19,796

Thereafter
67,726

Total estimated future amortization expense
$
157,072
v3.20.2
Balance sheet components
 9 Months Ended
Sep. 30, 2020
Balance Sheet Related Disclosures [Abstract]  
Balance sheet components Balance sheet components
Property and equipment, net
Property and equipment consisted of the following (in thousands):
 
September 30, 2020
 
December 31, 2019
Leasehold improvements
$
23,350

 
$
18,352

Laboratory equipment
32,676

 
24,873

Computer equipment
8,126

 
5,995

Software
2,649

 
2,611

Furniture and fixtures
1,277

 
1,198

Automobiles
58

 
58

Construction-in-progress
10,703

 
10,795

Total property and equipment, gross
78,839

 
63,882

Accumulated depreciation and amortization
(32,709
)
 
(26,135
)
Total property and equipment, net
$
46,130

 
$
37,747


Depreciation expense was $2.4 million and $1.8 million for the three months ended September 30, 2020 and 2019, respectively, and $6.8 million and $5.2 million for the nine months ended September 30, 2020 and 2019, respectively.
Accrued liabilities
Accrued liabilities consisted of the following (in thousands):
 
September 30, 2020
 
December 31, 2019
Accrued compensation and related expenses
$
20,552

 
$
16,440

Compensation and other liabilities associated with business combinations
38,905

 
30,560

Deferred revenue
1,917

 
1,429

Other
16,612

 
16,385

Total accrued liabilities
$
77,986

 
$
64,814
v3.20.2
Fair value measurements
 9 Months Ended
Sep. 30, 2020
Fair Value Disclosures [Abstract]  
Fair value measurements Fair value measurements
 
Financial assets and liabilities are recorded at fair value. Fair value is defined as the price that would be received to sell an asset or paid to transfer a liability (an exit price) in an orderly transaction between market participants at the reporting date. The authoritative guidance establishes a three-level valuation hierarchy that prioritizes the inputs to valuation techniques used to measure fair value based upon whether such inputs are observable or unobservable. Observable inputs reflect market data obtained from independent sources, while unobservable inputs reflect market assumptions made by the reporting entity.
The three-level hierarchy for the inputs to valuation techniques is summarized as follows:
Level 1—Observable inputs such as quoted prices (unadjusted) for identical instruments in active markets.
Level 2—Observable inputs such as quoted prices for similar instruments in active markets, quoted prices for identical or similar instruments in markets that are not active, or model-derived valuations whose significant inputs are observable.
Level 3—Unobservable inputs that reflect the reporting entity’s own assumptions.
The following tables set forth the fair value of our consolidated financial instruments that were measured at fair value on a recurring basis (in thousands):
 
September 30, 2020
 
Amortized
Cost
 
Unrealized
 
Estimated
Fair Value
 
 
 
 
 
 
 
 
Gains
 
Losses
 
 
Level 1
 
Level 2
 
Level 3
Financial assets:
 
 
 
 
 
 
 
 
 

 
 

 
 

Money market funds
$
7,017

 
$
—

 
$
—

 
$
7,017

 
$
7,017

 
$
—

 
$
—

U.S. treasury notes
162,163

 
182

 
—

 
162,345

 
162,345

 
—

 
—

U.S. government agency securities
92,486

 
17

 
—

 
92,503

 
—

 
92,503

 
—

Total financial assets
$
261,666

 
$
199

 
$
—

 
$
261,865

 
$
169,362

 
$
92,503

 
$
—

 
 
 
 
 
 
 
 
 
 
 
 
 
 
Financial liabilities:
 
 
 
 
 
 
 
 
 
 
 
 
 
Stock payable liability
 
 
 
 
 
 
$
53,330

 
$
—

 
$
—

 
$
53,330

Contingent consideration
 
 
 
 
 
 
12,290

 
—

 
—

 
12,290

Total financial liabilities
 
 
 
 
 
 
$
65,620

 
$
—

 
$
—

 
$
65,620

 
September 30, 2020
Reported as:
 

Cash equivalents
$
332

Restricted cash
6,685

Marketable securities
254,848

Total cash equivalents, restricted cash, and marketable securities
$
261,865

 
 
Accrued liabilities
$
10,500

Other long-term liabilities
$
55,120


 
December 31, 2019
 
Amortized
Cost
 
Unrealized
 
Estimated
Fair Value
 
 
 
 
 
 
 
 
Gains
 
Losses
 
 
Level 1
 
Level 2
 
Level 3
Financial assets:
 
 
 
 
 
 
 
 
 

 
 

 
 

Money market funds
$
39,396

 
$
—

 
$
—

 
$
39,396

 
$
39,396

 
$
—

 
$
—

Certificates of deposit
300

 
—

 
—

 
300

 
—

 
300

 
—

U.S. treasury notes
150,627

 
—

 
(15
)
 
150,612

 
150,612

 
—

 
—

U.S. government agency securities
193,302

 
6

 
—

 
193,308

 
—

 
193,308

 
—

Total financial assets
$
383,625

 
$
6

 
$
(15
)
 
$
383,616

 
$
190,008

 
$
193,608

 
$
—

 
 
 
 
 
 
 
 
 
 
 
 
 
 
Financial liabilities:
 
 
 
 
 
 
 
 
 
 
 
 
 
Contingent consideration
 
 
 
 
 
 
$
11,300

 
$
—

 
$
—

 
$
11,300

Total financial liabilities
 
 
 
 
 
 
$
11,300

 
$
—

 
$
—

 
$
11,300

 
December 31, 2019
Reported as:
 

Cash equivalents
$
136,997

Restricted cash
6,183

Marketable securities
240,436

Total cash equivalents, restricted cash, and marketable securities
$
383,616

 
 
Accrued liabilities
$
3,300

Other long-term liabilities
$
8,000


There were no transfers between Level 1, Level 2 and Level 3 during the periods presented. The total fair value of investments with unrealized losses at September 30, 2020 was $11.9 million. Our certificates of deposit and debt securities of U.S. government agency entities are classified as Level 2 as they are valued based upon quoted market prices for similar instruments in active markets, quoted prices for identical or similar instruments in markets that are not active and model-based valuation techniques for which all significant inputs are observable in the market or can be corroborated by observable market data for substantially the full term of the assets. Where applicable, these models project future cash flows and discount the future amounts to a present value using market-based observable inputs obtained from various third-party data providers, including but not limited to benchmark yields, interest rate curves, reported trades, broker/dealer quotes and reference data.
Stock payable liabilities relate to certain indemnification hold-backs resulting from business combinations that are settled in shares of our common stock. We elected to account for these liabilities using the fair value option due to the inherent nature of the liabilities and the changes in value of the underlying shares that will ultimately be issued to settle the liabilities. The estimated fair value of these liabilities is classified as Level 3 and determined based upon the number of shares that are issuable to the sellers and the quoted closing price of our common stock as of the reporting date. The number of shares that will ultimately be issued is subject to adjustment for indemnified claims that existed as of the closing date for each acquisition. Changes in the number of shares issued and share price can significantly affect the estimated fair value of the liabilities. During the three and nine months ended September 30, 2020, the change in fair value related to stock payable liabilities recorded to other income (expense), net was expense of $16.2 million and $37.9 million, respectively.
As of September 30, 2020, we had contingent obligations of $10.5 million of our common stock to the former owners of Jungla in connection with our acquisition of Jungla in July 2019. The amount of the contingent obligation is dependent upon achievement of certain post-close development milestones. We estimated the fair value of the contingent consideration as $10.7 million at the acquisition date in July 2019 using a discounted cash flow technique based on estimated achievement of the post-close milestones and discount rates which were Level 3 inputs not supported by market activity. These inputs can significantly affect the estimated fair value of the contingent consideration. The value of the liability is subsequently remeasured to fair value at each reporting date with changes recorded as general and administrative expense.
As of September 30, 2020, we had contingent obligations of $1.8 million of our common stock to the former owners of Genelex in connection with our acquisition of Genelex in April 2020. The amount of the contingent obligation is dependent upon achievement of a certain post-close milestone and the gross revenues actually received by us for a pharmacogenetic product reimbursed through certain payers during an earn-out period of up to four years. We estimated the fair value of the contingent consideration as $2.0 million at the acquisition date in April 2020 using a discounted cash flow technique based on estimated achievement of the post-close milestone, our estimate of amounts to ultimately be paid, and discount rates which were Level 3 inputs not supported by market activity. These inputs can significantly affect the estimated fair value of the contingent consideration. The value of the liability is subsequently remeasured to fair value at each reporting date with changes recorded as general and administrative expense.
v3.20.2
Commitments and contingencies
 9 Months Ended
Sep. 30, 2020
Commitments and Contingencies Disclosure [Abstract]  
Commitments and contingencies Commitments and contingencies
Leases
Operating leases
In 2015, we entered into a lease agreement for our headquarters and main production facility in San Francisco, California which commenced in 2016. This lease expires in 2026 and we may renew the lease for an additional ten years. This optional period was not considered reasonably certain to be exercised and therefore we determined the lease term to be a ten-year period expiring in 2026. In connection with the execution of the lease, we provided a security deposit of approximately $4.6 million which is included in restricted cash in our consolidated balance sheets. We also have other operating leases for office and laboratory space in California, Massachusetts, New York and Washington and internationally in Australia and Israel. We expect to enter into new leases and modifying existing leases as we support continued growth of our operations.
As of September 30, 2020, the weighted-average remaining lease term for our operating leases was 5.7 years and the weighted-average discount rate used to determine our operating lease liability was 11.3%. Cash payments included in the measurement of our operating lease liabilities were $3.0 million and $2.7 million for the three months ended September 30, 2020 and 2019, respectively, and $8.4 million and $7.6 million for the nine months ended September 30, 2020 and 2019, respectively.
The components of lease costs, which were included in cost of revenue, research and development, selling and marketing and general and administrative expenses on our consolidated statements of operations were as follows (in thousands):
 
Three Months Ended September 30,
 
Nine Months Ended September 30,
 
2020
 
2019
 
2020
 
2019
Operating lease costs
$
2,746

 
$
2,666

 
$
8,014

 
$
7,747

Sublease income
—

 
(43
)
 
—

 
(129
)
Finance lease costs
515

 
386

 
1,474

 
1,197

Total lease costs
$
3,261

 
$
3,009

 
$
9,488

 
$
8,815


Future minimum payments under non-cancelable operating leases as of September 30, 2020 are as follows (in thousands):
2020 (remainder of year)
$
1,991

2021
12,230

2022
11,530

2023
11,039

2024
11,182

Thereafter
19,698

Future non-cancelable minimum operating lease payments
67,670

Less: imputed interest
(18,679
)
Total operating lease liabilities
48,991

Less: current portion
(6,628
)
Operating lease obligations, net of current portion
$
42,363


Finance leases
We have entered into various finance lease agreements to obtain laboratory equipment. The terms of our finance leases are generally three years with a weighted-average remaining lease term of 2.5 years as of September 30, 2020 and are typically secured by the underlying equipment. The weighted-average discount rate used to determine our finance lease liability was 4.9%. The portion of the future payments designated as principal repayment and related interest was classified as a finance lease obligation on our consolidated balance sheets. Finance lease assets are recorded within other assets on our consolidated balance sheet and were $6.2 million and $5.6 million as of September 30, 2020 and December 31, 2019, respectively. Cash payments included in the measurement of our finance lease liabilities were $0.4 million and $0.5 million for the three months ended September 30, 2020 and 2019, respectively, and $1.7 million and $1.6 million for the nine months ended September 30, 2020 and 2019, respectively.
Future payments under finance leases at September 30, 2020 are as follows (in thousands):
2020 (remainder of year)
$
459

2021
1,184

2022
1,184

2023
436

Total finance lease obligations
3,263

Less: interest
(192
)
Present value of net minimum finance lease payments
3,071

Less: current portion
(1,237
)
Finance lease obligations, net of current portion
$
1,834


Debt financing
In November 2018, we entered into a Note Purchase Agreement (the "2018 Note Purchase Agreement") pursuant to which we were eligible to borrow an aggregate principal amount up to $200.0 million over a seven year maturity term which included an initial borrowing of $75.0 million in November 2018. We received net proceeds of $10.3 million after terminating and repaying the balance of our obligations of approximately $64.7 million with our previous lender.
In September 2019, we settled our obligations under the 2018 Note Purchase Agreement in full for $85.7 million, which included repayment of principal of $75.0 million, accrued interest of $2.4 million, and prepayment fees of $8.9 million which were recorded as debt extinguishment costs in other income (expense), net in our consolidated statement of operations during the three months ended September 30, 2019.
Interest expense related to our debt financings, excluding the impact of our Convertible Senior Notes (defined below), was nil and $1.6 million for the three months ended September 30, 2020 and 2019, respectively, and nil and $5.5 million for the nine months ended September 30, 2020 and 2019, respectively.
Convertible Senior Notes
In September 2019, we issued, at par value, $350.0 million aggregate principal amount of 2.00% Convertible Senior Notes due 2024 ("Convertible Senior Notes") in a private offering. The Convertible Senior Notes are our senior unsecured obligations and will mature on September 1, 2024, unless earlier converted, redeemed or repurchased. The Convertible Senior Notes bear cash interest at a rate of 2.0% per year, payable semi-annually in arrears on March 1 and September 1 of each year, beginning on March 1, 2020.
Upon conversion, the Convertible Senior Notes will be convertible into cash, shares of our common stock or a combination of cash and shares of our common stock, at our election. Our current intent is to settle the principal amount of the Convertible Senior Notes in cash upon conversion, with any remaining conversion value being delivered in shares of our common stock. The initial conversion rate for the Convertible Senior Notes is 33.6293 shares of our common stock per $1,000 principal amount of the Convertible Senior Notes (equivalent to an initial conversion price of approximately $29.74 per share of common stock).
If we undergo a fundamental change (as defined in the indenture governing the Convertible Senior Notes), the holders of the Convertible Senior Notes may require us to repurchase all or any portion of their Convertible Senior Notes for cash at a repurchase price equal to 100% of the principal amount of the Convertible Senior Notes to be repurchased plus accrued and unpaid interest to, but excluding, the redemption date.
The Convertible Senior Notes will be convertible at the option of the holders at any time prior to the close of business on the business day immediately preceding March 1, 2024, only under the following circumstances: (1) during any calendar quarter commencing after the calendar quarter ending on December 31, 2019 (and only during such calendar quarter), if the last reported sale price of our common stock for at least 20 trading days (whether or not consecutive) during a period of 30 consecutive trading days ending on, and including, the last trading day of the immediately preceding calendar quarter is greater than or equal to 130% of the conversion price for the Convertible Senior Notes on each applicable trading day; (2) during the five business day period after any five consecutive trading day period (the “measurement period”) in which the trading price per $1,000 principal amount of Convertible Senior Notes for each trading day of the measurement period was less than 98% of the product of the last reported sale price of our common stock and the conversion rate on each such trading day; (3) if we call any or all of the Convertible Senior Notes for redemption, at any time prior to the close of business on the scheduled trading day immediately preceding the redemption date; or (4) upon the occurrence of specified corporate events. On or after March 1, 2024 until the close of business on the business day immediately preceding the maturity date, holders may convert their Convertible Senior Notes at any time, regardless of the foregoing circumstances. As of September 30, 2020, none of the above circumstances had occurred and therefore the Convertible Senior Notes could not have been converted.
We may not redeem the Convertible Senior Notes prior to September 6, 2022. We may redeem for cash all or any portion of the Convertible Senior Notes, at our option, on or after September 6, 2022 and on or before the 30th scheduled trading day immediately before the maturity date if the last reported sale price of the Common Stock has been at least 130% of the conversion price then in effect for at least 20 trading days (whether or not consecutive) during any 30 consecutive trading day period (including the last trading day of such period) ending on, and including, the trading day immediately preceding the date on which we provide notice of redemption at a redemption price equal to 100% of the principal amount of the notes to be redeemed, plus accrued and unpaid interest to, but excluding, the redemption date.
The Convertible Senior Notes as of September 30, 2020 consisted of the following (in thousands):
Outstanding principal
$
350,000

Unamortized debt discount and issuance costs
(70,130
)
Net carrying amount, liability component
$
279,870


As of September 30, 2020, the fair value of the Convertible Senior Notes was $579.3 million. The estimated fair value of the Convertible Senior Notes, which are classified as Level 2 financial instruments, was determined based on the estimated or actual bid prices of the Convertible Senior Notes in an over-the-counter market. We recognized $5.5 million and $16.4 million of interest expense related to the Convertible Senior Notes during the three and nine months ended September 30, 2020, respectively, and $1.1 million during both the three and nine months ended September 30, 2019.
Other commitments
In the normal course of business, we enter into various purchase commitments primarily related to service agreements and laboratory supplies. At September 30, 2020, our total future payments under noncancelable unconditional purchase commitments having a remaining term of over one year were $7.7 million.
Guarantees and indemnifications
As permitted under Delaware law and in accordance with our bylaws, we indemnify our directors and officers for certain events or occurrences while the officer or director is or was serving in such capacity. The maximum amount of potential future indemnification is unlimited; however, we maintain director and officer liability insurance. This insurance allows the transfer of the risk associated with our exposure and may enable us to recover a portion of any future amounts paid. We believe the fair value of these indemnification agreements is minimal. Accordingly, we did not record any liabilities associated with these indemnification agreements at September 30, 2020 or December 31, 2019.
Contingencies
We were not a party to any material legal proceedings at September 30, 2020, or at the date of this report other than listed below which are related to ArcherDX which we acquired in October 2020. We cannot currently predict the outcome of these actions. We are and may from time to time become involved in various legal proceedings and claims arising in the ordinary course of business. While we believe any such claims are unsubstantiated, and we believe we are in compliance with applicable laws and regulations applicable to our business, the resolution of any such claims could be material.
Natera, Inc.
On January 27, 2020, Natera filed a lawsuit against ArcherDX (a subsidiary of Invitae effective October 2, 2020) in the United States District Court for the District of Delaware, alleging that ArcherDX’s products using AMP chemistry, and the manufacture, use, sale, and offer for sale of such products, infringe U.S. Patent No. 10,538,814. On March 25, 2020, ArcherDX filed an answer denying Natera’s allegations and asserting certain affirmative defenses and counterclaims, including that U.S. Patent No. 10,538,814 is invalid and not infringed. On April 15, 2020, Natera filed an answer denying ArcherDX’s counterclaims and filed an amended complaint alleging that ArcherDX’s products using AMP chemistry, including STRATAFIDE, PCM, LiquidPlex, ArcherMET, FusionPlex, and VariantPlex, and the manufacture, use, sale, and offer for sale of such products, infringe U.S. Patent No. 10,538,814, U.S. Patent No. 10,557,172, U.S. Patent No. 10,590,482, and U.S. Patent No. 10,597,708, each of which are held by Natera. Natera seeks, among other things, damages and other monetary relief, costs and attorneys’ fees, and an order enjoining ArcherDX from further infringement of such patents. On May 13, 2020, ArcherDX filed an answer to Natera’s amended complaint denying Natera’s allegations and asserting certain affirmative defenses and counterclaims, including that the asserted patents are invalid and not infringed. On June 3, 2020, Natera filed an answer denying ArcherDX’s counterclaims. On June 4, 2020, ArcherDX filed a motion seeking dismissal of Natera’s infringement claims against STRATAFIDE, PCM, and ArcherMET, and for a judgment that U.S. Patent No. 10,538,814, U.S. Patent No. 10,557,172, and U.S. Patent No. 10,590,482 are invalid. On August 6, 2020, Natera filed another complaint against ArcherDX in the United States District Court for the District of Delaware alleging that ArcherDX’s products using AMP chemistry, including STRATAFIDE, PCM, LiquidPlex, ArcherMET, and VariantPlex, and the manufacture, use, sale, and offer for sale of such products, infringe U.S. Patent No. 10,731,220. Natera seeks, among other things, damages and other monetary relief, costs and attorneys’ fees, and an order enjoining ArcherDX from further infringement of the patent. On October 13, 2020, the court issued an order denying ArcherDX's motion for dismissal of Natera’s infringement claims against STRATAFIDE, PCM, and ArcherMET, and declined to enter judgment that U.S. Patent No. 10,538,814, U.S. Patent No. 10,557,172, and U.S. Patent No. 10,590,482 are invalid. The litigations have now been consolidated for all purposes, are ongoing, and trial has been scheduled for May 2022.
QIAGEN Sciences
On July 10, 2018, ArcherDX and the General Hospital Corporation d/b/a Massachusetts General Hospital, which we refer to as MGH, filed a lawsuit in the United States District Court for the District of Delaware against QIAGEN Sciences, LLC, QIAGEN LLC, QIAGEN Beverly, Inc., QIAGEN Gaithersburg, Inc., QIAGEN GmbH and QIAGEN N.V., which is collectively referred to herein as QIAGEN, and a named QIAGEN executive who was a former member of ArcherDX’s board of directors, alleging several causes of action, including infringement of the ’810 Patent, trade secret misappropriation, breach of fiduciary duty, false advertising, tortious interference and deceptive trade practices. The ’810 Patent relates to methods for preparing a nucleic acid for sequencing and
aspects of ArcherDX’s AMP technology. On October 30, 2019, with the permission of the Court, ArcherDX amended ArcherDX’s complaint to add a claim for infringement of the ’597 Patent. The ’597 Patent relates to methods of preparing and analyzing nucleic acids, such as by enriching target sequences prior to sequencing, and aspects of ArcherDX’s AMP technology. The QIAGEN products that ArcherDX alleges infringe the ’810 Patent and the ’597 Patent include, but are not limited to, QIAseq Targeted DNA Panels, QIAseq Targeted RNAscan Panels, QIAseq Index Kits and QIAseq Immune Repertoire RNA Library Kits. ArcherDX is seeking, among other things, damages for ArcherDX’s lost profits due to QIAGEN’s infringement and a permanent injunction enjoining QIAGEN from marketing and selling the infringing products and from using ArcherDX’s trade secrets. On December 5, 2019, QIAGEN and the named QIAGEN executive submitted their answer denying the allegations in ArcherDX’s complaint and asserting affirmative defenses that, among other things, the ’810 Patent and ’597 Patent are not infringed by QIAGEN’s products, that both patents are invalid, and that the complaint fails to state any claim for which relief may be granted. This litigation is ongoing, and trial is currently scheduled for August 2021.
v3.20.2
Stockholders' equity
 9 Months Ended
Sep. 30, 2020
Equity [Abstract]  
Stockholders' equity Stockholders’ equity
Shares outstanding
Shares of convertible preferred and common stock were as follows (in thousands):
 
Three Months Ended September 30,
 
Nine Months Ended September 30,
 
2020
 
2019
 
2020
 
2019
Convertible preferred stock:
 
 
 
 
 
 
 
Shares outstanding, beginning of period
125

 
125

 
125

 
3,459

Conversion into common stock
—

 
—

 
—

 
(3,334
)
Shares outstanding, end of period
125

 
125

 
125

 
125

 
 
 
 
 
 
 
 
Common stock:
 
 
 
 
 
 
 
Shares outstanding, beginning of period
131,289

 
93,763

 
98,796

 
75,481

Common stock issued in connection with public offering
—

 
786

 
23,058

 
11,136

Common stock issued on exercise of stock options, net
245

 
71

 
553

 
411

Common stock issued pursuant to vesting of RSUs
1,322

 
476

 
4,803

 
1,721

Common stock issued pursuant to exercises of warrants
54

 
10

 
202

 
29

Common stock issued pursuant to employee stock purchase plan
—

 
—

 
342

 
235

Common stock issued pursuant to business combinations
358

 
1,409

 
5,514

 
4,168

Common stock issued upon conversion of preferred stock
—

 
—

 
—

 
3,334

Shares outstanding, end of period
133,268

 
96,515

 
133,268

 
96,515


2018 Sales Agreement
In August 2018, we entered into a Common Stock Sales Agreement (the “2018 Sales Agreement”) with Cowen and Company, LLC (“Cowen”) under which we may offer and sell from time to time at our sole discretion shares of our common stock through Cowen as our sales agent, in an aggregate amount not to exceed $75.0 million. Cowen may sell the shares by any method permitted by law deemed to be an “at the market” offering as defined in Rule 415 of the Securities Act of 1933, or Securities Act, including without limitation sales made directly on The New York Stock Exchange, and also may sell the shares in privately negotiated transactions, subject to our prior approval. Per the terms of the agreement, Cowen receives a commission equal to 3% of the gross proceeds of the sales price of all shares sold through it as sales agent under the 2018 Sales Agreement. In March 2019, we amended the 2018 Sales Agreement to increase the aggregate amount of our common stock to be sold under this agreement not to exceed $175.0 million. During the second quarter of 2020, we sold a total of 2.6 million shares of common stock under the 2018 Sales Agreement at an average price of $17.60 per share for aggregate gross proceeds of $46.0 million and net proceeds of $44.5 million.
Public offering
In April 2020, we sold, in an underwritten public offering, an aggregate of 20.4 million shares of our common stock at a price of $9.00 per share, for gross proceeds of $184.0 million and net proceeds of $173.0 million after deducting underwriting discounts and commissions and offering expenses.
v3.20.2
Stock incentive plans
 9 Months Ended
Sep. 30, 2020
Share-based Payment Arrangement [Abstract]  
Stock incentive plans Stock incentive plans
Stock incentive plans
In 2010, we adopted the 2010 Incentive Plan (the “2010 Plan”). The 2010 Plan provides for the granting of stock-based awards to employees, directors and consultants under terms and provisions established by our Board of Directors. Under the terms of the 2010 Plan, options may be granted at an exercise price not less than the fair market value of our common stock. For employees holding more than 10% of the voting rights of all classes of stock, the exercise prices for incentive and nonstatutory stock options must be at least 110% of fair market of our common stock on the grant date, as determined by our Board of Directors. The terms of options granted under the 2010 Plan may not exceed ten years.
In January 2015, we adopted the 2015 Stock Incentive Plan (the “2015 Plan”), which became effective upon the closing of our initial public offering (“IPO”). Shares outstanding under the 2010 Plan were transferred to the 2015 Plan upon effectiveness of the 2015 Plan. The 2015 Plan provides for automatic annual increases in shares available for grant, beginning on January 1, 2016 through January 1, 2025. In addition, shares subject to awards under the 2010 Plan that are forfeited or terminated will be added to the 2015 Plan. The 2015 Plan provides for the grant of incentive stock options, nonstatutory stock options, restricted stock awards, stock units, stock appreciation rights and other forms of equity compensation, all of which may be granted to employees, including officers, non-employee directors and consultants. Additionally, the 2015 Plan provides for the grant of cash-based awards. We amended and restated the 2015 Plan to create a pool of shares to be awarded solely as a material inducement to employees.
Options granted generally vest over a period of four years. Typically, the vesting schedule for options granted to newly hired employees provides that 1/4 of the award vests upon the first anniversary of the employee’s date of hire, with the remainder of the award vesting monthly thereafter at a rate of 1/48 of the total shares subject to the option. All other options typically vest in equal monthly installments over the four-year vesting schedule.
RSUs generally vest over a period of three years. Typically, the vesting schedule for RSUs provides that 1/3 of the award vests upon each anniversary of the grant date, with certain awards that include a portion that vests immediately upon grant. In June 2019, we granted Time-based RSUs in connection with the acquisition of Singular Bio which vest in three equal installments over a period of 18 months and PRSUs that vest based on the achievement of performance conditions; see further details in Note 4, "Business combinations."
Under our management incentive compensation plan, in July 2019 we granted PRSUs to our executive officers as well as other specified senior level employees based on the level of achievement of a specified 2019 revenue goal. One-third of the 0.8 million shares that were ultimately awarded under this plan vested during the nine months ended September 30, 2020 and the remaining awards will continue to vest over a period of two years. In June 2020, we granted 0.3 million PRSUs under this plan which are based on the level of achievement of a specified 2020 cash burn goal. These PRSUs will vest beginning in 2021 over a period of one year and may range from 0% to 100% of the target amount of shares, depending on eligibility and performance. As of September 30, 2020, these PRSUs had a fair value of $2.8 million based on an estimated issuance of 0.2 million shares and expectation of the performance condition.
Activity under the 2010 Plan and the 2015 Plan is set forth below (in thousands, except per share amounts and years):
 
Shares Available For Grant
 
Stock Options Outstanding
 
Weighted-Average Exercise Price Per Share
 
Weighted-Average Remaining Contractual Life (Years)
 
Aggregate Intrinsic Value
Balances at December 31, 2019
5,444

 
3,542

 
$
9.49

 
6.1
 
$
24,966

Additional shares reserved
4,649

 
—

 
 
 
 
 
 
Options granted
(295
)
 
295

 
17.26

 
 
 
 
Options exercised
—

 
(553
)
 
7.53

 
 
 
 
RSUs and PRSUs granted(1)
(3,241
)
 
—

 
 
 
 
 
 
RSUs and PRSUs cancelled
433

 
—

 
 
 
 
 
 
Balances at September 30, 2020
6,990

 
3,284

 
$
10.54

 
5.9
 
$
107,733

Options exercisable at September 30, 2020
 
 
2,767

 
$
9.50

 
5.4
 
$
93,648

Options vested and expected to vest at September 30, 2020
 
 
3,200

 
$
10.39

 
5.9
 
$
105,483


(1)
Includes the changes in the Time-based RSUs and PRSUs granted as a part of the Singular Bio acquisition in June 2019 which are based on a fixed dollar value. The number of shares issued will be variable until the awards vest. See further details in Note 4, "Business combinations."

The aggregate intrinsic value is calculated as the difference between the exercise price of the underlying stock options and the fair value of our common stock for stock options that were in-the-money.
In the nine months ended September 30, 2020 and 2019, the weighted-average fair value per share of options to purchase common stock granted was $10.10 and $14.52, respectively, and the total grant-date fair value of options to purchase common stock vested was $2.3 million and $3.6 million, respectively. The intrinsic value of options to purchase common stock exercised was $9.9 million and $5.8 million in the nine months ended September 30, 2020 and 2019, respectively.
The following table summarizes RSU activity, which includes the changes in Time-based RSUs and PRSUs granted in connection with our acquisition of Singular Bio (in thousands, except per share data):
 
Number of Shares
 
Weighted- Average Grant Date Fair Value Per Share
Balance at December 31, 2019
8,885

 
$
15.17

RSUs granted
4,545

 
$
18.53

Time-based RSUs and PRSUs granted - Singular Bio (1)
(1,578
)
 
$
25.85

PRSUs granted
274

 
$
16.17

RSUs vested
(4,803
)
 
$
17.98

RSUs cancelled
(433
)
 
$
18.40

Balance at September 30, 2020
6,890

 
$
12.82


 (1)
Includes the changes in the Time-based RSUs and PRSUs granted as a part of the Singular Bio acquisition in June 2019 which are based on a fixed dollar value. The number of shares issued will be variable until the awards vest which are adjusted above. The weighted-average grant date fair value per share reflects the fair value pricing of the full award. See further details in Note 4, "Business combinations."

 2015 Employee Stock Purchase Plan
In January 2015, we adopted the 2015 Employee Stock Purchase Plan (the “ESPP”), which became effective upon the closing of the IPO. Employees participating in the ESPP may purchase common stock at 85% of the lesser of the fair market value of common stock on the purchase date or last trading day preceding the offering date. At September 30, 2020, cash received from payroll deductions pursuant to the ESPP was $3.6 million. At September 30, 2020, a total of 1.2 million shares of common stock were reserved for issuance under the ESPP.
 Stock-based compensation
The following table summarizes stock-based compensation expense included in the consolidated statements of operations (in thousands): 
 
Three Months Ended September 30,
 
Nine Months Ended September 30,
 
2020
 
2019
 
2020
 
2019
Cost of revenue
$
2,104

 
$
822

 
$
5,321

 
$
3,678

Research and development
7,185

 
22,181

 
70,954

 
30,753

Selling and marketing
4,078

 
1,752

 
9,198

 
5,909

General and administrative
7,838

 
3,531

 
16,856

 
7,486

Total stock-based compensation expense
$
21,205

 
$
28,286

 
$
102,329

 
$
47,826
v3.20.2
Net loss per share
 9 Months Ended
Sep. 30, 2020
Earnings Per Share [Abstract]  
Net loss per share Net loss per share
The following table presents the calculation of basic and diluted net loss per share (in thousands, except per share amounts):
 
Three Months Ended September 30,
 
Nine Months Ended September 30,
 
2020
 
2019
 
2020
 
2019
Net loss
$
(102,902
)
 
$
(78,707
)
 
$
(367,832
)
 
$
(165,060
)
Shares used in computing net loss per share, basic and diluted
132,484

 
95,577

 
119,386

 
88,663

Net loss per share, basic and diluted
$
(0.78
)
 
$
(0.82
)
 
$
(3.08
)
 
$
(1.86
)

 
The following common stock equivalents have been excluded from diluted net loss per share because their inclusion would be anti-dilutive (in thousands): 
 
Three Months Ended September 30,
 
Nine Months Ended September 30,
 
2020
 
2019
 
2020
 
2019
Shares of common stock subject to outstanding options
3,365

 
3,647

 
3,419

 
3,691

Shares of common stock subject to outstanding warrants
330

 
586

 
396

 
596

Shares of common stock subject to outstanding RSUs
5,800

 
5,915

 
5,589

 
4,878

Shares of common stock subject to outstanding PRSUs
1,531

 
2,722

 
1,945

 
994

Shares of common stock pursuant to ESPP
312

 
229

 
316

 
219

Shares of common stock underlying Series A convertible preferred stock
125

 
125

 
125

 
896

Shares of common stock subject to convertible senior notes exercise
8,074

 
2,616

 
8,074

 
872

Total shares of common stock equivalents
19,537

 
15,840

 
19,864

 
12,146
v3.20.2
Geographic information
 9 Months Ended
Sep. 30, 2020
Segments, Geographical Areas [Abstract]  
Geographic information Geographic information
Revenue by country is determined based on the billing address of the customer. The following presents revenue by country (in thousands):
 
Three Months Ended September 30,
 
Nine Months Ended September 30,
 
2020
 
2019
 
2020
 
2019
United States
$
64,322

 
$
52,687

 
$
167,462

 
$
140,700

Canada
1,101

 
1,158

 
3,117

 
3,005

Rest of world
3,305

 
2,666

 
8,588

 
6,834

Total revenue
$
68,728

 
$
56,511

 
$
179,167

 
$
150,539
v3.20.2
Summary of significant accounting policies (Policies)
 9 Months Ended
Sep. 30, 2020
Accounting Policies [Abstract]  
Basis of presentation
Basis of presentation
The accompanying unaudited condensed consolidated financial statements have been prepared in accordance with U.S. generally accepted accounting principles (“U.S. GAAP”) for interim financial information and in accordance with the instructions to Form 10-Q and Rule 10-01 of Regulation S-X. Accordingly, they do not include all of the information and footnotes required by generally accepted accounting principles for complete financial statements. The unaudited interim condensed consolidated financial statements have been prepared on the same basis as the annual financial statements. In the opinion of management, the accompanying unaudited condensed consolidated financial statements reflect all adjustments (consisting only of normal recurring adjustments) considered necessary for a fair presentation. The information included in this Quarterly Report on Form 10-Q should be read in conjunction with the audited financial statements and notes thereto included in our Annual Report on Form 10-K for the year ended December 31, 2019. The results for the three and nine months ended September 30, 2020 are not necessarily indicative of the results expected for the full fiscal year or any other periods.   
Principles of consolidation
Principles of consolidation
Our unaudited condensed consolidated financial statements include our accounts and the accounts of our wholly-owned subsidiaries. All intercompany balances and transactions have been eliminated in consolidation.
Use of estimates
Use of estimates
The preparation of financial statements in conformity with U.S. GAAP requires management to make judgments, estimates and assumptions that affect the reported amounts of assets and liabilities and disclosure of contingent liabilities as of the date of the financial statements and the reported amounts of revenue and expenses during the reporting period. We base these estimates on current facts, historical and anticipated results, trends and various other assumptions that we believe are reasonable under the circumstances, including assumptions as to future events. Actual results could differ materially from those judgments, estimates and assumptions. We evaluate our estimates on an ongoing basis.
Concentrations of credit risk and other risks and uncertainties
Concentrations of credit risk and other risks and uncertainties
Financial instruments that potentially subject us to a concentration of credit risk consist of cash, cash equivalents, marketable securities and accounts receivable. Our cash and cash equivalents are primarily held by financial institutions in the United States. Such deposits may exceed federally insured limits.
Significant customers are those that represent 10% or more of our total revenue presented on the consolidated statements of operations.
Inventory
Inventory
We maintain test reagents and other consumables primarily used in sample collection kits which are valued at the lower of cost or net realizable value. Cost is determined using actual costs on a first-in, first-out basis.
Fair value of financial instruments
Fair value of financial instruments
Our financial instruments consist principally of cash and cash equivalents, marketable securities, accounts payable, accrued liabilities, finance leases and liabilities associated with business combinations. The carrying amounts of certain of these financial instruments, including cash and cash equivalents, accounts receivable, accounts payable and accrued and other current liabilities approximate their current fair value due to the relatively short-term nature of these accounts. Based on borrowing rates available to us, the carrying value of our finance leases approximate their fair values. Liabilities associated with business combinations are recorded at their estimated fair value.
Prior period reclassifications
Prior period reclassifications
We have reclassified certain amounts in prior periods to conform with current presentation.
Recent accounting pronouncements
Recent accounting pronouncements
We evaluate all Accounting Standards Updates (“ASUs”) issued by the Financial Accounting Standards Board ("FASB") for consideration of their applicability. ASUs not included in the disclosures in this report were assessed and determined to be either not applicable or are not expected to have a material impact on our consolidated financial statements.
In August 2020, the FASB issued ASU No. 2020-06, Accounting for Convertible Instruments and Contracts in an Entity's Own Equity, which simplifies the accounting for certain convertible instruments, amends the guidance on derivative scope exceptions for contracts in an entity's own equity, and modifies the guidance on diluted earnings per share calculations as a result of these changes. This new standard is effective for our interim and annual periods beginning January 1, 2022, and earlier adoption is permitted. We may elect to apply the amendments on a retrospective or modified retrospective basis. We are currently evaluating the impact of the adoption of this standard on our condensed consolidated financial statements.
Recently adopted accounting pronouncements
In June 2016, the FASB issued ASU 2016-13, Financial Instruments-Credit Losses (Topic 326), which requires measurement and recognition of expected credit losses for financial assets. This guidance became effective for us beginning in the first quarter of 2020 and was adopted using a modified retrospective approach, with certain exceptions. The adoption of Topic 326 did not have a material impact on our consolidated financial statements as credit losses are not expected to be significant.
As part of our adoption of Topic 326, we assess our accounts receivables for expected credit losses at each reporting period by disaggregating by payer type and further by portfolios of customers with similar characteristics, such as customer type and geographic location. We then review each portfolio for expected credit losses based on historical payment trends as well as forward looking data and current economic trends. If a credit loss is determined, we record a reduction to our accounts receivable balance with a corresponding general and administrative expense.
In accordance with Topic 326, we no longer evaluate whether our available-for-sale debt securities in an unrealized loss position are other than temporarily impaired. Instead, we assess whether such unrealized loss positions are credit-related. Our expected loss allowance methodology for these securities is developed by reviewing the extent of the unrealized loss, the issuers’ credit ratings and any changes in those ratings, as well as reviewing current and future economic market conditions and the issuers’ current status and financial condition. The credit-related portion of unrealized losses, and any subsequent improvements, are recorded in other income (expense), net. Unrealized gains and losses that are not credit-related are included in accumulated other comprehensive income (loss).
v3.20.2
Summary of significant accounting policies (Tables)
 9 Months Ended
Sep. 30, 2020
Accounting Policies [Abstract]  
Summary of significant customers as percentage of total revenue and total accounts receivable Our revenue from significant customers as a percentage of our total revenue was as follows:
 
 
Three Months Ended September 30,
 
Nine Months Ended September 30,
 
 
2020
 
2019
 
2020
 
2019
Medicare
 
20
%
 
27
%
 
20
%
 
23
%
Summary of restrictions on cash and cash equivalents
The following table provides a reconciliation of cash, cash equivalents and restricted cash reported within the consolidated balance sheets that sum to the total of the same amounts shown in the statements of cash flows (in thousands):
 
September 30,
2020
 
December 31,
2019
Cash and cash equivalents
$
106,436

 
$
151,389

Restricted cash
6,685

 
6,183

Total cash, cash equivalents and restricted cash
$
113,121

 
$
157,572
Schedule of cash and cash equivalents
The following table provides a reconciliation of cash, cash equivalents and restricted cash reported within the consolidated balance sheets that sum to the total of the same amounts shown in the statements of cash flows (in thousands):
 
September 30,
2020
 
December 31,
2019
Cash and cash equivalents
$
106,436

 
$
151,389

Restricted cash
6,685

 
6,183

Total cash, cash equivalents and restricted cash
$
113,121

 
$
157,572
v3.20.2
Revenue, accounts receivable and deferred revenue (Tables)
 9 Months Ended
Sep. 30, 2020
Revenue from Contract with Customer [Abstract]  
Schedule of disaggregated revenue by payer category
The following table includes our revenues as disaggregated by payer category (in thousands):
 
Three Months Ended September 30,
 
Nine Months Ended September 30,
 
2020
 
2019
 
2020
 
2019
Test revenue:
 
 
 
 
 
 
 
Institutions
$
14,015

 
$
10,407

 
$
37,043

 
$
28,375

Patient - direct
6,379

 
4,567

 
16,468

 
12,364

Patient - insurance
46,932

 
40,528

 
121,992

 
106,684

Total test revenue
67,326

 
55,502

 
175,503

 
147,423

Other revenue
1,402

 
1,009

 
3,664

 
3,116

Total revenue
$
68,728

 
$
56,511

 
$
179,167

 
$
150,539
Schedule of change in estimate As a result of new information, we update our estimates quarterly of the amounts to be recognized for previously delivered tests which resulted in the following increases to revenue and decreases to our loss from operations and basic and diluted net loss per share (in millions, except per share amounts):
 
Three Months Ended September 30,
 
Nine Months Ended September 30,
 
2020
 
2019
 
2020
 
2019
Revenue
$
0.7

 
$
1.2

 
$
3.0

 
$
4.0

Loss from operations
$
(0.7
)
 
$
(1.2
)
 
$
(3.0
)
 
$
(4.0
)
Net loss per share, basic and diluted
$
(0.01
)
 
$
(0.01
)
 
$
(0.03
)
 
$
(0.05
)
v3.20.2
Business combinations (Tables)
 9 Months Ended
Sep. 30, 2020
Business Combinations [Abstract]  
Summary of purchase price and post-combination expense
The following table summarizes the purchase prices recorded as a part of the acquisition of Genelex and YouScript (in thousands):
 
Genelex
 
YouScript
 
Total
Cash transferred
$
972

 
$
24,462

 
$
25,434

Hold-back consideration - cash
—

 
1,385

 
1,385

Hold-back consideration - common stock
781

 
5,392

 
6,173

Contingent consideration
1,994

 
—

 
1,994

Common stock transferred
9,463

 
21,464

 
30,927

Total
$
13,210

 
$
52,703

 
$
65,913


The following table summarizes the purchase price recorded as a part of the acquisition of Diploid (in thousands):
 
Purchase Price
Cash transferred
$
32,323

Hold-back consideration - common stock
7,538

Common stock transferred
42,453

Total
$
82,314
Summary of fair values of assets acquired and liabilities assumed The following table summarizes the fair values of assets acquired and liabilities assumed through our acquisitions of Genelex and YouScript at the date of acquisition (in thousands):
 
Genelex
 
YouScript
 
Total
Cash
$
33

 
$
24

 
$
57

Accounts receivable
221

 
56

 
277

Prepaid expenses and other current assets
—

 
70

 
70

Operating lease assets
—

 
355

 
355

Developed technology
9,209

 
25,716

 
34,925

Total identifiable assets acquired
9,463

 
26,221

 
35,684

Current liabilities
(320
)
 
(481
)
 
(801
)
Deferred tax liability
—

 
(2,600
)
 
(2,600
)
Other long-term liabilities
—

 
(163
)
 
(163
)
Net identifiable assets acquired
9,143

 
22,977

 
32,120

Goodwill
4,067

 
29,726

 
33,793

Total purchase price
$
13,210

 
$
52,703

 
$
65,913


The following table summarizes the fair values of assets acquired and liabilities assumed through our acquisition of Diploid at the date of acquisition (in thousands):
Cash
$
124

Accounts receivable
26

Developed technology
41,789

Total identifiable assets acquired
41,939

Accounts payable
(30
)
Deferred tax liability
(10,250
)
Net identifiable assets acquired
31,659

Goodwill
50,655

Total purchase price
$
82,314
v3.20.2
Goodwill and intangible assets (Tables)
 9 Months Ended
Sep. 30, 2020
Goodwill and Intangible Assets Disclosure [Abstract]  
Summary of goodwill
The changes in the carrying amounts of goodwill were as follows (in thousands):
Balance as of December 31, 2019
 
$
126,777

Goodwill acquired - Diploid
 
50,655

Goodwill acquired - Genelex
 
4,067

Goodwill acquired - YouScript
 
29,726

Balance as of September 30, 2020
 
$
211,225
Schedule of intangible assets
The following table presents details of our intangible assets (in thousands):
 
September 30, 2020
 
December 31, 2019
 
Cost
 
Accumulated
Amortization
 
Net
 
Weighted-Average
Useful Life
(in Years)
 
Cost
 
Accumulated
Amortization
 
Net
 
Weighted-Average
Useful Life
(in Years)
Customer relationships
$
23,763

 
$
(7,241
)
 
$
16,522

 
10.0
 
$
23,763

 
$
(5,141
)
 
$
18,622

 
10.0
Developed technology
161,110

 
(21,038
)
 
140,072

 
8.6
 
84,396

 
(8,476
)
 
75,920

 
8.6
Non-compete agreement
286

 
(215
)
 
71

 
5.0
 
286

 
(172
)
 
114

 
5.0
Trade name
576

 
(570
)
 
6

 
2.7
 
576

 
(480
)
 
96

 
2.7
Patent licensing agreement
496

 
(95
)
 
401

 
15.0
 
496

 
(70
)
 
426

 
15.0
Favorable leases
247

 
(247
)
 
—

 
2.2
 
247

 
(238
)
 
9

 
2.2
In-process research and development
29,988

 
—

 
29,988

 
n/a
 
29,988

 
—

 
29,988

 
n/a
 
$
216,466

 
$
(29,406
)
 
$
187,060

 
8.8
 
$
139,752

 
$
(14,577
)
 
$
125,175

 
8.9
Schedule of intangible assets
The following table presents details of our intangible assets (in thousands):
 
September 30, 2020
 
December 31, 2019
 
Cost
 
Accumulated
Amortization
 
Net
 
Weighted-Average
Useful Life
(in Years)
 
Cost
 
Accumulated
Amortization
 
Net
 
Weighted-Average
Useful Life
(in Years)
Customer relationships
$
23,763

 
$
(7,241
)
 
$
16,522

 
10.0
 
$
23,763

 
$
(5,141
)
 
$
18,622

 
10.0
Developed technology
161,110

 
(21,038
)
 
140,072

 
8.6
 
84,396

 
(8,476
)
 
75,920

 
8.6
Non-compete agreement
286

 
(215
)
 
71

 
5.0
 
286

 
(172
)
 
114

 
5.0
Trade name
576

 
(570
)
 
6

 
2.7
 
576

 
(480
)
 
96

 
2.7
Patent licensing agreement
496

 
(95
)
 
401

 
15.0
 
496

 
(70
)
 
426

 
15.0
Favorable leases
247

 
(247
)
 
—

 
2.2
 
247

 
(238
)
 
9

 
2.2
In-process research and development
29,988

 
—

 
29,988

 
n/a
 
29,988

 
—

 
29,988

 
n/a
 
$
216,466

 
$
(29,406
)
 
$
187,060

 
8.8
 
$
139,752

 
$
(14,577
)
 
$
125,175

 
8.9
Summary of estimated future amortization expense of intangible assets with finite lives
The following table summarizes our estimated future amortization expense of intangible assets with finite lives as of September 30, 2020 (in thousands):
2020 (remainder of year)
$
5,597

2021
22,792

2022
21,087

2023
20,074

2024
19,796

Thereafter
67,726

Total estimated future amortization expense
$
157,072
v3.20.2
Balance sheet components (Tables)
 9 Months Ended
Sep. 30, 2020
Balance Sheet Related Disclosures [Abstract]  
Schedule of property and equipment
Property and equipment consisted of the following (in thousands):
 
September 30, 2020
 
December 31, 2019
Leasehold improvements
$
23,350

 
$
18,352

Laboratory equipment
32,676

 
24,873

Computer equipment
8,126

 
5,995

Software
2,649

 
2,611

Furniture and fixtures
1,277

 
1,198

Automobiles
58

 
58

Construction-in-progress
10,703

 
10,795

Total property and equipment, gross
78,839

 
63,882

Accumulated depreciation and amortization
(32,709
)
 
(26,135
)
Total property and equipment, net
$
46,130

 
$
37,747
Schedule of accrued liabilities
Accrued liabilities consisted of the following (in thousands):
 
September 30, 2020
 
December 31, 2019
Accrued compensation and related expenses
$
20,552

 
$
16,440

Compensation and other liabilities associated with business combinations
38,905

 
30,560

Deferred revenue
1,917

 
1,429

Other
16,612

 
16,385

Total accrued liabilities
$
77,986

 
$
64,814
v3.20.2
Fair value measurements (Tables)
 9 Months Ended
Sep. 30, 2020
Fair Value Disclosures [Abstract]  
Financial instruments at fair value on a recurring basis
The following tables set forth the fair value of our consolidated financial instruments that were measured at fair value on a recurring basis (in thousands):
 
September 30, 2020
 
Amortized
Cost
 
Unrealized
 
Estimated
Fair Value
 
 
 
 
 
 
 
 
Gains
 
Losses
 
 
Level 1
 
Level 2
 
Level 3
Financial assets:
 
 
 
 
 
 
 
 
 

 
 

 
 

Money market funds
$
7,017

 
$
—

 
$
—

 
$
7,017

 
$
7,017

 
$
—

 
$
—

U.S. treasury notes
162,163

 
182

 
—

 
162,345

 
162,345

 
—

 
—

U.S. government agency securities
92,486

 
17

 
—

 
92,503

 
—

 
92,503

 
—

Total financial assets
$
261,666

 
$
199

 
$
—

 
$
261,865

 
$
169,362

 
$
92,503

 
$
—

 
 
 
 
 
 
 
 
 
 
 
 
 
 
Financial liabilities:
 
 
 
 
 
 
 
 
 
 
 
 
 
Stock payable liability
 
 
 
 
 
 
$
53,330

 
$
—

 
$
—

 
$
53,330

Contingent consideration
 
 
 
 
 
 
12,290

 
—

 
—

 
12,290

Total financial liabilities
 
 
 
 
 
 
$
65,620

 
$
—

 
$
—

 
$
65,620

 
September 30, 2020
Reported as:
 

Cash equivalents
$
332

Restricted cash
6,685

Marketable securities
254,848

Total cash equivalents, restricted cash, and marketable securities
$
261,865

 
 
Accrued liabilities
$
10,500

Other long-term liabilities
$
55,120


 
December 31, 2019
 
Amortized
Cost
 
Unrealized
 
Estimated
Fair Value
 
 
 
 
 
 
 
 
Gains
 
Losses
 
 
Level 1
 
Level 2
 
Level 3
Financial assets:
 
 
 
 
 
 
 
 
 

 
 

 
 

Money market funds
$
39,396

 
$
—

 
$
—

 
$
39,396

 
$
39,396

 
$
—

 
$
—

Certificates of deposit
300

 
—

 
—

 
300

 
—

 
300

 
—

U.S. treasury notes
150,627

 
—

 
(15
)
 
150,612

 
150,612

 
—

 
—

U.S. government agency securities
193,302

 
6

 
—

 
193,308

 
—

 
193,308

 
—

Total financial assets
$
383,625

 
$
6

 
$
(15
)
 
$
383,616

 
$
190,008

 
$
193,608

 
$
—

 
 
 
 
 
 
 
 
 
 
 
 
 
 
Financial liabilities:
 
 
 
 
 
 
 
 
 
 
 
 
 
Contingent consideration
 
 
 
 
 
 
$
11,300

 
$
—

 
$
—

 
$
11,300

Total financial liabilities
 
 
 
 
 
 
$
11,300

 
$
—

 
$
—

 
$
11,300

 
December 31, 2019
Reported as:
 

Cash equivalents
$
136,997

Restricted cash
6,183

Marketable securities
240,436

Total cash equivalents, restricted cash, and marketable securities
$
383,616

 
 
Accrued liabilities
$
3,300

Other long-term liabilities
$
8,000
v3.20.2
Commitments and contingencies (Tables)
 9 Months Ended
Sep. 30, 2020
Commitments and Contingencies Disclosure [Abstract]  
Components of lease cost
The components of lease costs, which were included in cost of revenue, research and development, selling and marketing and general and administrative expenses on our consolidated statements of operations were as follows (in thousands):
 
Three Months Ended September 30,
 
Nine Months Ended September 30,
 
2020
 
2019
 
2020
 
2019
Operating lease costs
$
2,746

 
$
2,666

 
$
8,014

 
$
7,747

Sublease income
—

 
(43
)
 
—

 
(129
)
Finance lease costs
515

 
386

 
1,474

 
1,197

Total lease costs
$
3,261

 
$
3,009

 
$
9,488

 
$
8,815
Schedule of future minimum payments under operating leases
Future minimum payments under non-cancelable operating leases as of September 30, 2020 are as follows (in thousands):
2020 (remainder of year)
$
1,991

2021
12,230

2022
11,530

2023
11,039

2024
11,182

Thereafter
19,698

Future non-cancelable minimum operating lease payments
67,670

Less: imputed interest
(18,679
)
Total operating lease liabilities
48,991

Less: current portion
(6,628
)
Operating lease obligations, net of current portion
$
42,363
Schedule of future minimum lease payments under finance leases
Future payments under finance leases at September 30, 2020 are as follows (in thousands):
2020 (remainder of year)
$
459

2021
1,184

2022
1,184

2023
436

Total finance lease obligations
3,263

Less: interest
(192
)
Present value of net minimum finance lease payments
3,071

Less: current portion
(1,237
)
Finance lease obligations, net of current portion
$
1,834
Components of debt
The Convertible Senior Notes as of September 30, 2020 consisted of the following (in thousands):
Outstanding principal
$
350,000

Unamortized debt discount and issuance costs
(70,130
)
Net carrying amount, liability component
$
279,870
v3.20.2
Stockholders' equity (Tables)
 9 Months Ended
Sep. 30, 2020
Equity [Abstract]  
Schedule of convertible preferred and common stock
Shares of convertible preferred and common stock were as follows (in thousands):
 
Three Months Ended September 30,
 
Nine Months Ended September 30,
 
2020
 
2019
 
2020
 
2019
Convertible preferred stock:
 
 
 
 
 
 
 
Shares outstanding, beginning of period
125

 
125

 
125

 
3,459

Conversion into common stock
—

 
—

 
—

 
(3,334
)
Shares outstanding, end of period
125

 
125

 
125

 
125

 
 
 
 
 
 
 
 
Common stock:
 
 
 
 
 
 
 
Shares outstanding, beginning of period
131,289

 
93,763

 
98,796

 
75,481

Common stock issued in connection with public offering
—

 
786

 
23,058

 
11,136

Common stock issued on exercise of stock options, net
245

 
71

 
553

 
411

Common stock issued pursuant to vesting of RSUs
1,322

 
476

 
4,803

 
1,721

Common stock issued pursuant to exercises of warrants
54

 
10

 
202

 
29

Common stock issued pursuant to employee stock purchase plan
—

 
—

 
342

 
235

Common stock issued pursuant to business combinations
358

 
1,409

 
5,514

 
4,168

Common stock issued upon conversion of preferred stock
—

 
—

 
—

 
3,334

Shares outstanding, end of period
133,268

 
96,515

 
133,268

 
96,515
v3.20.2
Stock incentive plans (Tables)
 9 Months Ended
Sep. 30, 2020
Share-based Payment Arrangement [Abstract]  
Schedule of activity under the plans
Activity under the 2010 Plan and the 2015 Plan is set forth below (in thousands, except per share amounts and years):
 
Shares Available For Grant
 
Stock Options Outstanding
 
Weighted-Average Exercise Price Per Share
 
Weighted-Average Remaining Contractual Life (Years)
 
Aggregate Intrinsic Value
Balances at December 31, 2019
5,444

 
3,542

 
$
9.49

 
6.1
 
$
24,966

Additional shares reserved
4,649

 
—

 
 
 
 
 
 
Options granted
(295
)
 
295

 
17.26

 
 
 
 
Options exercised
—

 
(553
)
 
7.53

 
 
 
 
RSUs and PRSUs granted(1)
(3,241
)
 
—

 
 
 
 
 
 
RSUs and PRSUs cancelled
433

 
—

 
 
 
 
 
 
Balances at September 30, 2020
6,990

 
3,284

 
$
10.54

 
5.9
 
$
107,733

Options exercisable at September 30, 2020
 
 
2,767

 
$
9.50

 
5.4
 
$
93,648

Options vested and expected to vest at September 30, 2020
 
 
3,200

 
$
10.39

 
5.9
 
$
105,483


(1)
Includes the changes in the Time-based RSUs and PRSUs granted as a part of the Singular Bio acquisition in June 2019 which are based on a fixed dollar value. The number of shares issued will be variable until the awards vest. See further details in Note 4, "Business combinations."
Summary of RSU activity
The following table summarizes RSU activity, which includes the changes in Time-based RSUs and PRSUs granted in connection with our acquisition of Singular Bio (in thousands, except per share data):
 
Number of Shares
 
Weighted- Average Grant Date Fair Value Per Share
Balance at December 31, 2019
8,885

 
$
15.17

RSUs granted
4,545

 
$
18.53

Time-based RSUs and PRSUs granted - Singular Bio (1)
(1,578
)
 
$
25.85

PRSUs granted
274

 
$
16.17

RSUs vested
(4,803
)
 
$
17.98

RSUs cancelled
(433
)
 
$
18.40

Balance at September 30, 2020
6,890

 
$
12.82


 (1)
Includes the changes in the Time-based RSUs and PRSUs granted as a part of the Singular Bio acquisition in June 2019 which are based on a fixed dollar value. The number of shares issued will be variable until the awards vest which are adjusted above. The weighted-average grant date fair value per share reflects the fair value pricing of the full award. See further details in Note 4, "Business combinations."
Summary of stock based compensation expense
The following table summarizes stock-based compensation expense included in the consolidated statements of operations (in thousands): 
 
Three Months Ended September 30,
 
Nine Months Ended September 30,
 
2020
 
2019
 
2020
 
2019
Cost of revenue
$
2,104

 
$
822

 
$
5,321

 
$
3,678

Research and development
7,185

 
22,181

 
70,954

 
30,753

Selling and marketing
4,078

 
1,752

 
9,198

 
5,909

General and administrative
7,838

 
3,531

 
16,856

 
7,486

Total stock-based compensation expense
$
21,205

 
$
28,286

 
$
102,329

 
$
47,826
v3.20.2
Net loss per share (Tables)
 9 Months Ended
Sep. 30, 2020
Earnings Per Share [Abstract]  
Schedule of earnings per share, basic and diluted
The following table presents the calculation of basic and diluted net loss per share (in thousands, except per share amounts):
 
Three Months Ended September 30,
 
Nine Months Ended September 30,
 
2020
 
2019
 
2020
 
2019
Net loss
$
(102,902
)
 
$
(78,707
)
 
$
(367,832
)
 
$
(165,060
)
Shares used in computing net loss per share, basic and diluted
132,484

 
95,577

 
119,386

 
88,663

Net loss per share, basic and diluted
$
(0.78
)
 
$
(0.82
)
 
$
(3.08
)
 
$
(1.86
)
Schedule of antidilutive securities excluded from computation of earnings per share
The following common stock equivalents have been excluded from diluted net loss per share because their inclusion would be anti-dilutive (in thousands): 
 
Three Months Ended September 30,
 
Nine Months Ended September 30,
 
2020
 
2019
 
2020
 
2019
Shares of common stock subject to outstanding options
3,365

 
3,647

 
3,419

 
3,691

Shares of common stock subject to outstanding warrants
330

 
586

 
396

 
596

Shares of common stock subject to outstanding RSUs
5,800

 
5,915

 
5,589

 
4,878

Shares of common stock subject to outstanding PRSUs
1,531

 
2,722

 
1,945

 
994

Shares of common stock pursuant to ESPP
312

 
229

 
316

 
219

Shares of common stock underlying Series A convertible preferred stock
125

 
125

 
125

 
896

Shares of common stock subject to convertible senior notes exercise
8,074

 
2,616

 
8,074

 
872

Total shares of common stock equivalents
19,537

 
15,840

 
19,864

 
12,146
v3.20.2
Geographic information (Tables)
 9 Months Ended
Sep. 30, 2020
Segments, Geographical Areas [Abstract]  
Schedule of revenue by country The following presents revenue by country (in thousands):
 
Three Months Ended September 30,
 
Nine Months Ended September 30,
 
2020
 
2019
 
2020
 
2019
United States
$
64,322

 
$
52,687

 
$
167,462

 
$
140,700

Canada
1,101

 
1,158

 
3,117

 
3,005

Rest of world
3,305

 
2,666

 
8,588

 
6,834

Total revenue
$
68,728

 
$
56,511

 
$
179,167

 
$
150,539
v3.20.2
Organization and description of business - Additional Information (Details)
gene in Thousands
 9 Months Ended 12 Months Ended
Sep. 30, 2020
Segment
gene
Dec. 31, 2019
business
Organization, Consolidation and Presentation of Financial Statements [Abstract]    
Number of genes | gene 20  
Number of businesses acquired | business   4
Number of operating segments | Segment 1  
v3.20.2
Summary of significant accounting policies - Summary of significant customers as percentage of total revenue and total accounts receivable (Details)
 3 Months Ended 9 Months Ended
Sep. 30, 2020
Sep. 30, 2019
Sep. 30, 2020
Sep. 30, 2019
Customer Concentration Risk | Revenue | Medicare        
Summary Of Significant Accounting Policies [Line Items]        
Concentration risk 20.00% 27.00% 20.00% 23.00%
v3.20.2
Summary of significant accounting policies - Reconciliation of cash, cash equivalents and restricted cash (Details) - USD ($)
$ in Thousands
Sep. 30, 2020
Dec. 31, 2019
Sep. 30, 2019
Dec. 31, 2018
Accounting Policies [Abstract]        
Cash and cash equivalents $ 106,436 $ 151,389    
Restricted cash 6,685 6,183    
Total cash, cash equivalents and restricted cash $ 113,121 $ 157,572 $ 473,195 $ 118,164
v3.20.2
Summary of significant accounting policies - Additional information (Details) - USD ($)
$ in Thousands
 3 Months Ended 9 Months Ended
Sep. 30, 2020
Mar. 31, 2020
Sep. 30, 2019
Sep. 30, 2020
Sep. 30, 2019
Jun. 30, 2020
Dec. 31, 2019
Jun. 30, 2019
Dec. 31, 2018
Business Acquisition [Line Items]                  
Inventory $ 14,900     $ 14,900     $ 6,600    
Decrease to stockholders' equity (416,551)   $ (403,881) (416,551) $ (403,881)   (379,640)    
Other expense, net (15,771)   (7,591) (32,499) (5,572)        
Immaterial error related to classification of Indemnification from acquisition | Restatement adjustment                  
Business Acquisition [Line Items]                  
Long-term liabilities   $ 10,100              
Other expense, net   300              
Additional paid-in capital:                  
Business Acquisition [Line Items]                  
Decrease to stockholders' equity $ (1,542,848)   $ (1,085,643) $ (1,542,848) $ (1,085,643) $ (1,487,217) (1,138,316) $ (944,559) $ (678,548)
Additional paid-in capital: | Immaterial error related to classification of Indemnification from acquisition | Restatement adjustment                  
Business Acquisition [Line Items]                  
Decrease to stockholders' equity   $ 10,400         $ 10,387    
v3.20.2
Revenue, accounts receivable and deferred revenue - Schedule of disaggregated revenue by payer category (Details) - USD ($)
$ in Thousands
 3 Months Ended 9 Months Ended
Sep. 30, 2020
Sep. 30, 2019
Sep. 30, 2020
Sep. 30, 2019
Disaggregation of Revenue [Line Items]        
Total revenue $ 68,728 $ 56,511 $ 179,167 $ 150,539
Test revenue        
Disaggregation of Revenue [Line Items]        
Total revenue 67,326 55,502 175,503 147,423
Test revenue | Institutions        
Disaggregation of Revenue [Line Items]        
Total revenue 14,015 10,407 37,043 28,375
Test revenue | Patient - direct        
Disaggregation of Revenue [Line Items]        
Total revenue 6,379 4,567 16,468 12,364
Test revenue | Patient - insurance        
Disaggregation of Revenue [Line Items]        
Total revenue 46,932 40,528 121,992 106,684
Other revenue        
Disaggregation of Revenue [Line Items]        
Total revenue $ 1,402 $ 1,009 $ 3,664 $ 3,116
v3.20.2
Revenue, accounts receivable and deferred revenue - Schedule of change in estimate (Details) - USD ($)
$ / shares in Units, $ in Thousands
 3 Months Ended 9 Months Ended
Sep. 30, 2020
Sep. 30, 2019
Sep. 30, 2020
Sep. 30, 2019
Revenue, Initial Application Period Cumulative Effect Transition [Line Items]        
Total revenue $ 68,728 $ 56,511 $ 179,167 $ 150,539
Loss from operations $ 80,823 $ 76,983 $ 320,689 $ 165,076
Net loss per share, basic and diluted $ 0.78 $ 0.82 $ 3.08 $ 1.86
Change in estimate of revenue recognition        
Revenue, Initial Application Period Cumulative Effect Transition [Line Items]        
Total revenue $ 700 $ 1,200 $ 3,000 $ 4,000
Loss from operations $ (700) $ (1,200) $ (3,000) $ (4,000)
Net loss per share, basic and diluted $ (0.01) $ (0.01) $ (0.03) $ (0.05)
v3.20.2
Revenue, accounts receivable and deferred revenue - Additional information (Details) - USD ($)
$ in Millions
 1 Months Ended 3 Months Ended 9 Months Ended
May 31, 2020
Apr. 30, 2020
Jun. 30, 2020
Sep. 30, 2020
Restructuring Cost and Reserve [Line Items]        
Revenue re-requisition rights period       90 days
One-time termination costs        
Restructuring Cost and Reserve [Line Items]        
Positions eliminated, percent of total workforce   8.00%    
Restructuring charges     $ 3.8  
Reduction in officer salary 20.00%      
CARES Act        
Restructuring Cost and Reserve [Line Items]        
Income received under the CARES Act   $ 3.8    
v3.20.2
Business combinations - Singular Bio (Details) - USD ($)
shares in Thousands, $ in Thousands
 1 Months Ended 3 Months Ended 9 Months Ended
Apr. 30, 2020
Jun. 30, 2019
Sep. 30, 2020
Sep. 30, 2019
Sep. 30, 2020
Sep. 30, 2019
Business Acquisition [Line Items]            
Business combination, total purchase consideration $ 65,913          
Stock-based compensation expense (income)     $ 21,205 $ 28,286 $ 102,329 $ 47,826
Singular Bio            
Business Acquisition [Line Items]            
Percentage of diluted interest acquired   100.00%        
Business combination, total purchase consideration   $ 57,300        
Common stock transferred   $ 53,900        
Business acquisition common stock issued (in shares)   2,500        
Stock incentive plans            
Business Acquisition [Line Items]            
Vesting period         4 years  
Stock incentive plans | Singular Bio            
Business Acquisition [Line Items]            
RSUs granted (in shares)         3,700  
Fair value of units vested         $ 60,900  
RSU            
Business Acquisition [Line Items]            
RSUs granted (in shares)         4,545  
Vested stock units awarded (in shares)         4,803  
RSU | Stock incentive plans            
Business Acquisition [Line Items]            
Vesting period         3 years  
RSU | Stock incentive plans | Singular Bio            
Business Acquisition [Line Items]            
Business acquisition, value of units granted   $ 90,000        
RSU - Time based | Stock incentive plans | Singular Bio            
Business Acquisition [Line Items]            
Business acquisition, value of units granted   45,000 46,500   $ 46,500  
Stock-based compensation expense (income)     6,300 6,700 $ 24,900 7,600
Vested stock units awarded (in shares)         1,700  
PRSU            
Business Acquisition [Line Items]            
RSUs granted (in shares)         274  
PRSU | Stock incentive plans | Singular Bio            
Business Acquisition [Line Items]            
Business acquisition, value of units granted   $ 45,000 37,400   $ 37,400  
Vesting period   12 months     18 months  
Stock-based compensation expense (income)     $ (6,500) $ 11,900 $ 23,600 $ 13,600
Vested stock units awarded (in shares)         1,200  
First anniversary | RSU | Stock incentive plans            
Business Acquisition [Line Items]            
Vesting rate upon anniversaries         33.33%  
First anniversary | RSU | Stock incentive plans | Singular Bio            
Business Acquisition [Line Items]            
Vesting rate upon anniversaries   33.33%     33.33%  
Second anniversary | RSU | Stock incentive plans            
Business Acquisition [Line Items]            
Vesting rate upon anniversaries         33.33%  
Second anniversary | RSU | Stock incentive plans | Singular Bio            
Business Acquisition [Line Items]            
Vesting rate upon anniversaries   33.33%     33.33%  
Third anniversary | RSU | Stock incentive plans            
Business Acquisition [Line Items]            
Vesting rate upon anniversaries         33.33%  
Third anniversary | RSU | Stock incentive plans | Singular Bio            
Business Acquisition [Line Items]            
Vesting rate upon anniversaries   33.33%     33.33%  
v3.20.2
Business combinations - Jungla (Details) - USD ($)
$ in Thousands, shares in Millions
 1 Months Ended 9 Months Ended
Apr. 30, 2020
Jul. 31, 2019
Sep. 30, 2020
Business Acquisition [Line Items]      
Business combination, total purchase consideration $ 65,913    
Jungla      
Business Acquisition [Line Items]      
Percentage of diluted interest acquired   100.00%  
Business combination, total purchase consideration   $ 59,000  
Common stock transferred   44,900  
Ongoing development post-close milestones | Jungla      
Business Acquisition [Line Items]      
Contingent consideration   $ 10,700  
Business acquisition, expected milestone duration   2 years  
Indemnification obligations | Jungla      
Business Acquisition [Line Items]      
Business acquisition common stock issued (in shares)     0.2
v3.20.2
Business combinations - Clear Genetics (Details) - USD ($)
$ in Thousands, shares in Millions
 1 Months Ended 3 Months Ended 9 Months Ended
Apr. 30, 2020
Nov. 30, 2019
Jun. 30, 2020
Sep. 30, 2020
Business Acquisition [Line Items]        
Business combination, total purchase consideration $ 65,913      
Hold-back consideration - cash 1,385      
Hold-back consideration - common stock $ 6,173      
Clear Genetics        
Business Acquisition [Line Items]        
Percentage of diluted interest acquired   100.00%    
Business combination, total purchase consideration   $ 50,100    
Common stock issued pursuant to business combinations (in shares)     0.1  
Hold-back consideration - common stock       $ 12,200
Indemnification obligations | Clear Genetics        
Business Acquisition [Line Items]        
Hold-back consideration - cash   $ 200    
Business acquisition common stock issued (in shares)   0.4   0.3
v3.20.2
Business combinations - Diploid (Details) - USD ($)
shares in Thousands, $ in Thousands
 1 Months Ended 9 Months Ended 12 Months Ended
Jun. 30, 2020
Apr. 30, 2020
Mar. 31, 2020
Sep. 30, 2020
Dec. 31, 2019
Business Acquisition [Line Items]          
Business combination, total purchase consideration   $ 65,913      
Useful life       8 years 9 months 18 days 8 years 10 months 24 days
Hold-back consideration - common stock   $ 6,173      
Goodwill       $ 211,225 $ 126,777
Diploid          
Business Acquisition [Line Items]          
Percentage of diluted interest acquired     100.00%    
Business combination, total purchase consideration     $ 82,314    
Useful life     9 years    
Hold-back consideration - common stock     $ 7,538    
Contingent consideration       $ 18,300  
Goodwill     $ 50,655    
Indemnification obligations | Diploid          
Business Acquisition [Line Items]          
Business acquisition common stock issued (in shares)     400    
First anniversary | Stock incentive plans | Diploid          
Business Acquisition [Line Items]          
Vesting rate upon anniversaries 50.00%        
Second anniversary | Stock incentive plans | Diploid          
Business Acquisition [Line Items]          
Vesting rate upon anniversaries 50.00%        
RSU          
Business Acquisition [Line Items]          
RSUs granted (in shares)       4,545  
RSU | Stock incentive plans | Diploid          
Business Acquisition [Line Items]          
RSUs granted (in shares) 200        
Business acquisition, value of units granted $ 3,600        
RSU | First anniversary | Stock incentive plans          
Business Acquisition [Line Items]          
Vesting rate upon anniversaries       33.33%  
RSU | Second anniversary | Stock incentive plans          
Business Acquisition [Line Items]          
Vesting rate upon anniversaries       33.33%  
v3.20.2
Business combinations - Summary of the purchase price and post-combination expense (Details) - USD ($)
$ in Thousands
 1 Months Ended
Apr. 30, 2020
Mar. 31, 2020
Purchase Price    
Cash transferred $ 25,434  
Hold-back consideration - cash 1,385  
Hold-back consideration - common stock 6,173  
Contingent consideration 1,994  
Common stock transferred 30,927  
Total 65,913  
Diploid    
Purchase Price    
Cash transferred   $ 32,323
Hold-back consideration - common stock   7,538
Common stock transferred   42,453
Total   $ 82,314
Genelex    
Purchase Price    
Cash transferred 972  
Hold-back consideration - cash 0  
Hold-back consideration - common stock 781  
Contingent consideration 1,994  
Common stock transferred 9,463  
Total 13,210  
YouScript    
Purchase Price    
Cash transferred 24,462  
Hold-back consideration - cash 1,385  
Hold-back consideration - common stock 5,392  
Contingent consideration 0  
Common stock transferred 21,464  
Total $ 52,703  
v3.20.2
Business combinations - Summary of fair values of assets acquired and liabilities assumed (Details) - USD ($)
$ in Thousands
Sep. 30, 2020
Apr. 30, 2020
Mar. 31, 2020
Dec. 31, 2019
Business Acquisition [Line Items]        
Goodwill $ 211,225     $ 126,777
Diploid        
Business Acquisition [Line Items]        
Cash     $ 124  
Accounts receivable     26  
Intangible assets     41,789  
Total identifiable assets acquired     41,939  
Accounts payable     (30)  
Deferred tax liability     (10,250)  
Net identifiable assets acquired     31,659  
Goodwill     50,655  
Total purchase price     $ 82,314  
Genelex        
Business Acquisition [Line Items]        
Cash   $ 33    
Accounts receivable   221    
Prepaid expenses and other current assets   0    
Operating lease assets   0    
Intangible assets   9,209    
Total identifiable assets acquired   9,463    
Current liabilities   (320)    
Deferred tax liability   0    
Other long-term liabilities   0    
Net identifiable assets acquired   9,143    
Goodwill   4,067    
Total purchase price   13,210    
YouScript        
Business Acquisition [Line Items]        
Cash   24    
Accounts receivable   56    
Prepaid expenses and other current assets   70    
Operating lease assets   355    
Intangible assets   25,716    
Total identifiable assets acquired   26,221    
Current liabilities   (481)    
Deferred tax liability   (2,600)    
Other long-term liabilities   (163)    
Net identifiable assets acquired   22,977    
Goodwill   29,726    
Total purchase price   52,703    
Genelex and YouScript        
Business Acquisition [Line Items]        
Cash   57    
Accounts receivable   277    
Prepaid expenses and other current assets   70    
Operating lease assets   355    
Intangible assets   34,925    
Total identifiable assets acquired   35,684    
Current liabilities   (801)    
Deferred tax liability   (2,600)    
Other long-term liabilities   (163)    
Net identifiable assets acquired   32,120    
Goodwill   33,793    
Total purchase price   $ 65,913    
v3.20.2
Business combinations - Genelex and YouScript (Details) - USD ($)
$ in Thousands, shares in Millions
 1 Months Ended 9 Months Ended 12 Months Ended
Apr. 30, 2020
Sep. 30, 2020
Dec. 31, 2019
Business Acquisition [Line Items]      
Business combination, total purchase consideration $ 65,913    
Cash transferred 25,434    
Hold-back consideration - common stock $ 6,173    
Weighted-Average Useful Life (in Years)   8 years 9 months 18 days 8 years 10 months 24 days
Goodwill   $ 211,225 $ 126,777
Genelex      
Business Acquisition [Line Items]      
Percentage of diluted interest acquired 100.00%    
Business combination, total purchase consideration $ 13,210    
Cash transferred 972    
Hold-back consideration - common stock $ 781    
Business acquisition, expected milestone duration 4 years    
Contingent consideration $ 2,000    
Weighted-Average Useful Life (in Years) 8 years    
Goodwill $ 4,067    
YouScript      
Business Acquisition [Line Items]      
Percentage of diluted interest acquired 100.00%    
Business combination, total purchase consideration $ 52,703    
Cash transferred 24,462    
Hold-back consideration - common stock $ 5,392    
Weighted-Average Useful Life (in Years) 8 years    
Goodwill $ 29,726    
Genelex and YouScript      
Business Acquisition [Line Items]      
Hold-back consideration - common stock 6,200 22,400  
Transaction costs   $ 1,100  
Goodwill $ 33,793    
Indemnification obligations | Genelex      
Business Acquisition [Line Items]      
Business acquisition common stock issued (in shares) 0.1    
Indemnification obligations | YouScript      
Business Acquisition [Line Items]      
Business acquisition common stock issued (in shares) 0.5    
Hold-back consideration - common stock $ 1,400    
v3.20.2
Business combinations - ArcherDX (Details) - USD ($)
$ / shares in Units, shares in Millions
 1 Months Ended 3 Months Ended 9 Months Ended
Oct. 31, 2020
Sep. 30, 2020
Apr. 30, 2020
Sep. 30, 2019
Sep. 30, 2020
Sep. 30, 2019
Business Acquisition [Line Items]            
Cash transferred     $ 25,434,000      
Proceeds from issuance of common stock         $ 9,076,000 $ 5,734,000
Common stock:            
Business Acquisition [Line Items]            
Common stock issued       $ 1,000 $ 3,000 $ 2,000
Private placement | Common stock: | ArcherDX            
Business Acquisition [Line Items]            
Proceeds from issuance of common stock   $ 5,000,000.0        
Subsequent event | ArcherDX            
Business Acquisition [Line Items]            
Business acquisition common stock issued (in shares) 30.0          
Cash transferred $ 325,000,000.0          
Subsequent event | Milestone achievement agreement | ArcherDX            
Business Acquisition [Line Items]            
Business acquisition common stock issued (in shares) 27.0          
Subsequent event | Debt financing contingency | ArcherDX            
Business Acquisition [Line Items]            
Warrants issued (in shares) 1.0          
Exercise price (in dollars per share) $ 16.85          
Subsequent event | Private placement | Common stock: | ArcherDX            
Business Acquisition [Line Items]            
Common stock issued $ 275,000,000.0          
Shares issued price per share (in dollars per share) $ 16.85          
Secured Debt | Subsequent event | 2020 Term Loan | ArcherDX            
Business Acquisition [Line Items]            
Aggregate principal amount $ 135,000,000.0          
Stated interest rate 2.00%          
LIBOR | Secured Debt | Subsequent event | 2020 Term Loan | ArcherDX            
Business Acquisition [Line Items]            
Floor rate 2.00%          
Basis spread on variable rate 8.75%          
v3.20.2
Goodwill and intangible assets - Summary of goodwill (Details)
$ in Thousands
 9 Months Ended
Sep. 30, 2020
USD ($)
Goodwill [Line Items]  
Beginning Balance $ 126,777
Ending Balance 211,225
Diploid  
Goodwill [Line Items]  
Goodwill acquired 50,655
Genelex  
Goodwill [Line Items]  
Goodwill acquired 4,067
YouScript  
Goodwill [Line Items]  
Goodwill acquired $ 29,726
v3.20.2
Goodwill and intangible assets - Schedule of intangible assets (Details) - USD ($)
$ in Thousands
 9 Months Ended 12 Months Ended
Sep. 30, 2020
Dec. 31, 2019
Finite-Lived Intangible Assets [Line Items]    
Accumulated Amortization $ (29,406) $ (14,577)
Total estimated future amortization expense $ 157,072  
Weighted-Average Useful Life (in Years) 8 years 9 months 18 days 8 years 10 months 24 days
Cost $ 216,466 $ 139,752
Net 187,060 125,175
Customer relationships    
Finite-Lived Intangible Assets [Line Items]    
Cost, finite intangible 23,763 23,763
Accumulated Amortization (7,241) (5,141)
Total estimated future amortization expense $ 16,522 $ 18,622
Weighted-Average Useful Life (in Years) 10 years 10 years
Developed technology    
Finite-Lived Intangible Assets [Line Items]    
Cost, finite intangible $ 161,110 $ 84,396
Accumulated Amortization (21,038) (8,476)
Total estimated future amortization expense $ 140,072 $ 75,920
Weighted-Average Useful Life (in Years) 8 years 7 months 6 days 8 years 7 months 6 days
Non-compete agreement    
Finite-Lived Intangible Assets [Line Items]    
Cost, finite intangible $ 286 $ 286
Accumulated Amortization (215) (172)
Total estimated future amortization expense $ 71 $ 114
Weighted-Average Useful Life (in Years) 5 years 5 years
Trade name    
Finite-Lived Intangible Assets [Line Items]    
Cost, finite intangible $ 576 $ 576
Accumulated Amortization (570) (480)
Total estimated future amortization expense $ 6 $ 96
Weighted-Average Useful Life (in Years) 2 years 8 months 12 days 2 years 8 months 12 days
Patent licensing agreement    
Finite-Lived Intangible Assets [Line Items]    
Cost, finite intangible $ 496 $ 496
Accumulated Amortization (95) (70)
Total estimated future amortization expense $ 401 $ 426
Weighted-Average Useful Life (in Years) 15 years 15 years
Favorable leases    
Finite-Lived Intangible Assets [Line Items]    
Cost, finite intangible $ 247 $ 247
Accumulated Amortization (247) (238)
Total estimated future amortization expense $ 0 $ 9
Weighted-Average Useful Life (in Years) 2 years 2 months 12 days 2 years 2 months 12 days
In-process research and development    
Finite-Lived Intangible Assets [Line Items]    
In-process research and development $ 29,988 $ 29,988
v3.20.2
Goodwill and intangible assets - Additional information (Details) - USD ($)
$ in Millions
 3 Months Ended 9 Months Ended
Sep. 30, 2020
Sep. 30, 2019
Sep. 30, 2020
Sep. 30, 2019
Goodwill and Intangible Assets Disclosure [Abstract]        
Amortization expense $ 5.6 $ 2.2 $ 14.8 $ 4.9
v3.20.2
Goodwill and intangible assets - Summary of estimated future amortization expense of intangible assets with finite lives (Details)
$ in Thousands
Sep. 30, 2020
USD ($)
Goodwill and Intangible Assets Disclosure [Abstract]  
2020 (remainder of year) $ 5,597
2021 22,792
2022 21,087
2023 20,074
2024 19,796
Thereafter 67,726
Total estimated future amortization expense $ 157,072
v3.20.2
Balance sheet components - Schedule of property and equipment (Details) - USD ($)
$ in Thousands
Sep. 30, 2020
Dec. 31, 2019
Property and equipment    
Total property and equipment, gross $ 78,839 $ 63,882
Accumulated depreciation and amortization (32,709) (26,135)
Total property and equipment, net 46,130 37,747
Leasehold improvements    
Property and equipment    
Total property and equipment, gross 23,350 18,352
Laboratory equipment    
Property and equipment    
Total property and equipment, gross 32,676 24,873
Computer equipment    
Property and equipment    
Total property and equipment, gross 8,126 5,995
Software    
Property and equipment    
Total property and equipment, gross 2,649 2,611
Furniture and fixtures    
Property and equipment    
Total property and equipment, gross 1,277 1,198
Automobiles    
Property and equipment    
Total property and equipment, gross 58 58
Construction-in-progress    
Property and equipment    
Total property and equipment, gross $ 10,703 $ 10,795
v3.20.2
Balance sheet components - Additional information (Details) - USD ($)
$ in Millions
 3 Months Ended 9 Months Ended
Sep. 30, 2020
Sep. 30, 2019
Sep. 30, 2020
Sep. 30, 2019
Balance Sheet Related Disclosures [Abstract]        
Depreciation $ 2.4 $ 1.8 $ 6.8 $ 5.2
v3.20.2
Balance sheet components - Schedule of accrued liabilities (Details) - USD ($)
$ in Thousands
Sep. 30, 2020
Dec. 31, 2019
Balance Sheet Related Disclosures [Abstract]    
Accrued compensation and related expenses $ 20,552 $ 16,440
Compensation and other liabilities associated with business combinations 38,905 30,560
Deferred revenue 1,917 1,429
Other 16,612 16,385
Total accrued liabilities $ 77,986 $ 64,814
v3.20.2
Fair value measurements - Financial instruments at fair value on a recurring basis (Details) - USD ($)
$ in Thousands
Sep. 30, 2020
Dec. 31, 2019
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]    
Amortized Cost $ 261,666 $ 383,625
Unrealized Gains 199 6
Unrealized Losses 0 (15)
Financial assets: 261,865 383,616
Cash equivalents 332 136,997
Restricted cash 6,685 6,183
Marketable securities 254,848 240,436
Recurring basis    
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]    
Total financial assets 261,865 383,616
Total financial liabilities 65,620 11,300
Recurring basis | Level 1    
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]    
Total financial assets 169,362 190,008
Total financial liabilities 0 0
Recurring basis | Level 2    
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]    
Total financial assets 92,503 193,608
Total financial liabilities 0 0
Recurring basis | Level 3    
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]    
Total financial assets 0 0
Total financial liabilities 65,620 11,300
Money market funds    
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]    
Amortized Cost 7,017 39,396
Unrealized Gains 0 0
Unrealized Losses 0 0
Money market funds | Recurring basis    
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]    
Financial assets: 7,017 39,396
Money market funds | Recurring basis | Level 1    
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]    
Financial assets: 7,017 39,396
Money market funds | Recurring basis | Level 2    
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]    
Financial assets: 0 0
Money market funds | Recurring basis | Level 3    
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]    
Financial assets: 0 0
Certificates of deposit    
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]    
Amortized Cost   300
Unrealized Gains   0
Unrealized Losses   0
Certificates of deposit | Recurring basis    
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]    
Financial assets:   300
Certificates of deposit | Recurring basis | Level 1    
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]    
Financial assets:   0
Certificates of deposit | Recurring basis | Level 2    
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]    
Financial assets:   300
Certificates of deposit | Recurring basis | Level 3    
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]    
Financial assets:   0
U.S. treasury notes    
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]    
Amortized Cost 162,163 150,627
Unrealized Gains 182 0
Unrealized Losses 0 (15)
U.S. treasury notes | Recurring basis    
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]    
Financial assets: 162,345 150,612
U.S. treasury notes | Recurring basis | Level 1    
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]    
Financial assets: 162,345 150,612
U.S. treasury notes | Recurring basis | Level 2    
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]    
Financial assets: 0 0
U.S. treasury notes | Recurring basis | Level 3    
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]    
Financial assets: 0 0
U.S. government agency securities    
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]    
Amortized Cost 92,486 193,302
Unrealized Gains 17 6
Unrealized Losses 0 0
U.S. government agency securities | Recurring basis    
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]    
Financial assets: 92,503 193,308
U.S. government agency securities | Recurring basis | Level 1    
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]    
Financial assets: 0 0
U.S. government agency securities | Recurring basis | Level 2    
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]    
Financial assets: 92,503 193,308
U.S. government agency securities | Recurring basis | Level 3    
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]    
Financial assets: 0 0
Stock payable liability | Recurring basis    
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]    
Total financial liabilities 53,330  
Stock payable liability | Recurring basis | Level 1    
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]    
Total financial liabilities 0  
Stock payable liability | Recurring basis | Level 2    
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]    
Total financial liabilities 0  
Stock payable liability | Recurring basis | Level 3    
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]    
Total financial liabilities 53,330  
Contingent consideration | Recurring basis    
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]    
Total financial liabilities 12,290 11,300
Contingent consideration | Recurring basis | Level 1    
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]    
Total financial liabilities 0 0
Contingent consideration | Recurring basis | Level 2    
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]    
Total financial liabilities 0 0
Contingent consideration | Recurring basis | Level 3    
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]    
Total financial liabilities 12,290 11,300
Accrued liabilities    
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]    
Total financial liabilities 10,500 3,300
Other long-term liabilities    
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]    
Total financial liabilities $ 55,120 $ 8,000
v3.20.2
Fair value measurements - Additional information (Details) - USD ($)
 1 Months Ended 3 Months Ended 9 Months Ended
Apr. 30, 2020
Jul. 31, 2019
Sep. 30, 2020
Sep. 30, 2020
Dec. 31, 2019
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]          
Transfers of assets and liabilities between Level 1, Level 2 and Level 3     $ 0 $ 0 $ 0
Fair value of investments with unrealized losses       11,900,000  
Change in fair value, expense     $ 16,200,000 $ 37,900,000  
Change in fair value, statement of operations location     us-gaap:OtherNonrecurringIncomeExpense us-gaap:OtherNonrecurringIncomeExpense  
Genelex          
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]          
Business acquisition, expected milestone duration 4 years        
Ongoing development post-close milestones | Jungla          
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]          
Business acquisition, expected milestone duration   2 years      
Level 3 | Contingent consideration | Ongoing development post-close milestones | Jungla          
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]          
Contingent obligation, fair value   $ 10,700,000 $ 10,500,000 $ 10,500,000  
Level 3 | Contingent consideration | Ongoing development post-close milestones | Genelex          
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]          
Contingent obligation, fair value $ 2,000,000.0   $ 1,800,000 $ 1,800,000  
v3.20.2
Commitments and contingencies - Operating lease - Additional information (Details) - USD ($)
$ in Millions
 3 Months Ended 9 Months Ended
Sep. 30, 2020
Sep. 30, 2019
Sep. 30, 2020
Sep. 30, 2019
Dec. 31, 2015
Lessor, Lease, Description [Line Items]          
Weighted-average remaining lease term 5 years 8 months 12 days   5 years 8 months 12 days    
Weighted-average discount rate 11.30%   11.30%    
Operating lease, cash payments $ 3.0 $ 2.7 $ 8.4 $ 7.6  
New Leases | Office Facility In San Francisco          
Lessor, Lease, Description [Line Items]          
Additional term of lease         10 years
Lease term         10 years
Security Deposit         $ 4.6
v3.20.2
Commitments and contingencies - Components of lease cost (Details) - USD ($)
$ in Thousands
 3 Months Ended 9 Months Ended
Sep. 30, 2020
Sep. 30, 2019
Sep. 30, 2020
Sep. 30, 2019
Commitments and Contingencies Disclosure [Abstract]        
Operating lease costs $ 2,746 $ 2,666 $ 8,014 $ 7,747
Sublease income 0 (43) 0 (129)
Finance lease costs 515 386 1,474 1,197
Total lease costs $ 3,261 $ 3,009 $ 9,488 $ 8,815
v3.20.2
Commitments and contingencies - Schedule of future minimum payments under operating leases (Details) - USD ($)
$ in Thousands
Sep. 30, 2020
Dec. 31, 2019
Future minimum lease payments under operating leases    
2020 (remainder of year) $ 1,991  
2021 12,230  
2022 11,530  
2023 11,039  
2024 11,182  
Thereafter 19,698  
Future non-cancelable minimum operating lease payments 67,670  
Less: imputed interest (18,679)  
Total operating lease liabilities 48,991  
Less: current portion (6,628) $ (4,870)
Operating lease obligations, net of current portion $ 42,363 $ 42,191
v3.20.2
Commitments and contingencies - Finance lease - Additional information (Details) - USD ($)
$ in Millions
 3 Months Ended 9 Months Ended
Sep. 30, 2020
Sep. 30, 2019
Sep. 30, 2020
Sep. 30, 2019
Dec. 31, 2019
Commitments and Contingencies Disclosure [Abstract]          
Lease term 3 years   3 years    
Weighted-average remaining lease term 2 years 6 months   2 years 6 months    
Weighted-average discount rate 4.90%   4.90%    
Finance lease assets $ 6.2   $ 6.2   $ 5.6
Finance lease assets, balance sheet location us-gaap:OtherAssetsNoncurrent   us-gaap:OtherAssetsNoncurrent   us-gaap:OtherAssetsNoncurrent
Finance lease, cash payments $ 0.4 $ 0.5 $ 1.7 $ 1.6  
v3.20.2
Commitments and contingencies - Schedule of future minimum lease payments under finance leases (Details) - USD ($)
$ in Thousands
Sep. 30, 2020
Dec. 31, 2019
Future payments under the finance lease    
2020 (remainder of year) $ 459  
2021 1,184  
2022 1,184  
2023 436  
Total finance lease obligations 3,263  
Less: interest (192)  
Present value of net minimum finance lease payments 3,071  
Less: current portion (1,237) $ (1,855)
Finance lease obligations, net of current portion $ 1,834 $ 1,155
v3.20.2
Commitments and contingencies - Debt financing - Additional information (Details) - USD ($)
 1 Months Ended 3 Months Ended 9 Months Ended
Sep. 30, 2019
Nov. 30, 2018
Sep. 30, 2020
Sep. 30, 2019
Sep. 30, 2020
Sep. 30, 2019
Long-term Purchase Commitment [Line Items]            
Payments of debt extinguishment costs         $ 0 $ 10,638,000
Note Purchase Agreement            
Long-term Purchase Commitment [Line Items]            
Maximum borrowing capacity   $ 200,000,000.0        
Maturity term   7 years        
Repayment of debt $ 85,700,000          
Repayment of principal 75,000,000.0          
Repayment of accrued interest 2,400,000          
Payments of debt extinguishment costs $ 8,900,000          
Initial sale of notes | Note Purchase Agreement            
Long-term Purchase Commitment [Line Items]            
Maximum borrowing capacity   $ 75,000,000.0        
Proceeds from notes sold   10,300,000        
Loan and Security Agreement | Secured Debt            
Long-term Purchase Commitment [Line Items]            
Repayment of term loan   $ 64,700,000        
Interest expense     $ 0 $ 1,600,000 $ 0 $ 5,500,000
v3.20.2
Commitments and contingencies - Convertible Senior Notes - Additional information (Details)
 1 Months Ended 3 Months Ended 9 Months Ended
Sep. 30, 2019
USD ($)
Trading_day
$ / shares
Sep. 30, 2020
USD ($)
Sep. 30, 2019
USD ($)
$ / shares
Sep. 30, 2020
USD ($)
Sep. 30, 2019
USD ($)
$ / shares
Convertible debt | Convertible Senior Notes          
Debt Instrument [Line Items]          
Aggregate principal amount | $ $ 350,000,000.0   $ 350,000,000.0   $ 350,000,000.0
Stated interest rate 2.00%   2.00%   2.00%
Conversion ratio 0.0336293        
Conversion price (in dollars per share) | $ / shares $ 29.74   $ 29.74   $ 29.74
Redemption price, percent of principle 100.00%        
Number of trading days 20        
Number of consecutive trading days 30        
Threshold percentage of stock price trigger 130.00%        
Number of trading days immediately after five consecutive trading days 5        
Threshold percentage of stock price trigger, maximum 98.00%        
Redemption period, number of trading days 30        
Interest expense | $   $ 5,500,000 $ 1,100,000 $ 16,400,000 $ 1,100,000
Level 2          
Debt Instrument [Line Items]          
Convertible debt fair value | $   $ 579,300,000   $ 579,300,000  
v3.20.2
Commitments and contingencies - Components of debt (Details) - Convertible debt - Convertible Senior Notes
$ in Thousands
Sep. 30, 2020
USD ($)
Debt Instrument [Line Items]  
Outstanding principal $ 350,000
Unamortized debt discount and issuance costs (70,130)
Net carrying amount, liability component $ 279,870
v3.20.2
Commitments and contingencies - Other commitments - Additional information (Details)
$ in Millions
Sep. 30, 2020
USD ($)
Service Agreements and Laboratory Supplies  
Other Commitments [Line Items]  
Noncancelable unconditional purchase commitments $ 7.7
v3.20.2
Stockholders' equity - Schedule of convertible preferred and common stock (Details) - shares
shares in Thousands
 3 Months Ended 9 Months Ended
Sep. 30, 2020
Sep. 30, 2019
Sep. 30, 2020
Sep. 30, 2019
Convertible preferred stock:        
Increase (Decrease) in Stockholders' Equity [Roll Forward]        
Shares outstanding, beginning of period 125 125 125 3,459
Shares converted 0 0 0 (3,334)
Shares outstanding, end of period 125 125 125 125
Common stock:        
Increase (Decrease) in Stockholders' Equity [Roll Forward]        
Shares outstanding, beginning of period 131,289 93,763 98,796 75,481
Shares converted 0 0 0 (3,334)
Common stock issued in connection with public offering (in shares) 0 786 23,058 11,136
Common stock issued on exercise of stock options, net (in shares) 245 71 553 411
Common stock issued pursuant to vesting of RSUs (in shares) 1,322 476 4,803 1,721
Common stock issued pursuant to exercises of warrants (in shares) 54 10 202 29
Common stock issued pursuant to employee stock purchase plan (in shares) 0 0 342 235
Common stock issued pursuant to business combinations (in shares) 358 1,409 5,514 4,168
Shares outstanding, end of period 133,268 96,515 133,268 96,515
v3.20.2
Stockholders' equity - Additional information (Details) - USD ($)
 1 Months Ended 3 Months Ended 9 Months Ended
Apr. 30, 2020
Mar. 31, 2019
Aug. 31, 2018
Jun. 30, 2020
Sep. 30, 2020
Sep. 30, 2019
Class of Stock [Line Items]            
Proceeds from issuance of common stock, net         $ 9,076,000 $ 5,734,000
Common stock | Underwritten Public Offering            
Class of Stock [Line Items]            
Proceeds from issuance of common stock, net $ 184,000,000.0          
Number of shares sold in underwritten public offering 20,400,000          
Shares issued price per share (in dollars per share) $ 9.00          
Net proceeds from issuance of common stock $ 173,000,000.0          
2018 Sales Agreement | Cowen and Company, LLC            
Class of Stock [Line Items]            
Proceeds from issuance of common stock, net       $ 46,000,000.0    
Percentage of commission payable on gross proceeds     3.00%      
Number of shares sold in underwritten public offering       2,600,000    
Shares issued price per share (in dollars per share)       $ 17.60    
Net proceeds from issuance of common stock       $ 44,500,000    
2018 Sales Agreement | Maximum | Cowen and Company, LLC            
Class of Stock [Line Items]            
Proceeds from issuance of common stock, net   $ 175,000,000.0 $ 75,000,000.0      
v3.20.2
Stock incentive plans - Additional information (Details) - USD ($)
$ / shares in Units, $ in Millions
 1 Months Ended 9 Months Ended
Jun. 30, 2020
Jul. 31, 2019
Jun. 30, 2019
Jan. 31, 2015
Sep. 30, 2020
Sep. 30, 2019
RSU            
Stock incentive plan            
Vested stock units awarded (in shares)         4,803,000  
RSUs granted (in shares)         4,545,000  
PRSU            
Stock incentive plan            
RSUs granted (in shares)         274,000  
Stock incentive plans            
Stock incentive plan            
Vesting period         4 years  
Stock incentive plans | RSU            
Stock incentive plan            
Vesting period         3 years  
Stock incentive plans | Stock options            
Stock incentive plan            
Vesting period         4 years  
Vesting rate upon anniversaries         25.00%  
Monthly vesting rate thereafter         2.08%  
Options granted (in dollars per share)         $ 10.10 $ 14.52
Total grant date fair value of options to purchase common stock vested         $ 2.3 $ 3.6
Exercised, aggregate intrinsic value         $ 9.9 $ 5.8
Stock incentive plans | First anniversary | RSU            
Stock incentive plan            
Vesting rate upon anniversaries         33.33%  
Stock incentive plans | Second anniversary | RSU            
Stock incentive plan            
Vesting rate upon anniversaries         33.33%  
Stock incentive plans | Third anniversary | RSU            
Stock incentive plan            
Vesting rate upon anniversaries         33.33%  
2019 Incentive Compensation Plan | PRSU            
Stock incentive plan            
Vesting period 1 year 2 years        
Vested stock units awarded (in shares)         800,000  
RSUs granted (in shares) 300,000          
Fair value         $ 2.8  
Shares reserved for future issuance         200,000  
2015 Employee Stock Purchase Plan            
Stock incentive plan            
Shares reserved for future issuance         1,200,000  
Purchase price of common stock of the lesser of fair market value on the purchase date or the last trading day preceding the offering date       85.00%    
Cash received from payroll deductions         $ (3.6)  
Minimum | 2010 Plan            
Stock incentive plan            
Employees holding voting rights of all classes of stock         10.00%  
Exercise price of options on common stock         110.00%  
Minimum | 2019 Incentive Compensation Plan | PRSU            
Stock incentive plan            
Potential payout, target percentage 0.00%          
Maximum | 2010 Plan            
Stock incentive plan            
Term of options granted         10 years  
Maximum | 2019 Incentive Compensation Plan | PRSU            
Stock incentive plan            
Potential payout, target percentage 100.00%          
Singular Bio | Stock incentive plans            
Stock incentive plan            
RSUs granted (in shares)         3,700,000  
Singular Bio | Stock incentive plans | RSU            
Stock incentive plan            
Fair value     $ 90.0      
Singular Bio | Stock incentive plans | PRSU            
Stock incentive plan            
Vesting period     12 months   18 months  
Vested stock units awarded (in shares)         1,200,000  
Fair value     $ 45.0   $ 37.4  
Singular Bio | Stock incentive plans | First anniversary | RSU            
Stock incentive plan            
Vesting rate upon anniversaries     33.33%   33.33%  
Singular Bio | Stock incentive plans | Second anniversary | RSU            
Stock incentive plan            
Vesting rate upon anniversaries     33.33%   33.33%  
Singular Bio | Stock incentive plans | Third anniversary | RSU            
Stock incentive plan            
Vesting rate upon anniversaries     33.33%   33.33%  
v3.20.2
Stock incentive plans - Schedule of activity under the plans (Details) - Stock incentive plans
$ / shares in Units, shares in Thousands, $ in Thousands
 9 Months Ended 12 Months Ended
Sep. 30, 2020
USD ($)
$ / shares
shares
Dec. 31, 2019
USD ($)
$ / shares
shares
Stock options    
Activity under the plan    
Shares available for grant, beginning balance (in shares) 5,444  
Stock options outstanding, beginning balance (in shares) 3,542  
Additional shares reserved (in shares) 4,649  
Options granted (in shares) 295  
Options exercised (in shares) (553)  
Shares available for grant, ending balance (in shares) 6,990 5,444
Stock options outstanding, ending balance (in shares) 3,284 3,542
Weighted-Average Exercise Price    
Balance at the beginning of the period (in dollars per share) | $ / shares $ 9.49  
Options granted (in dollars per share) | $ / shares 17.26  
Options exercised (in dollars per share) | $ / shares 7.53  
Balance at the end of the period (in dollars per share) | $ / shares $ 10.54 $ 9.49
Additional information    
Exercisable, number of shares 2,767  
Exercisable, weighted-average exercise price (in dollars per share) | $ / shares $ 9.50  
Weighted-average remaining contractual life 5 years 10 months 24 days 6 years 1 month 6 days
Aggregate Intrinsic Value | $ $ 107,733 $ 24,966
Exercisable, weighted-average remaining contractual life 5 years 4 months 24 days  
Exercisable, aggregate intrinsic value | $ $ 93,648  
Vested and expected to vest    
Number of shares 3,200  
Weighted-average exercise price (in dollars per share) | $ / shares $ 10.39  
Weighted-average remaining contractual life 5 years 10 months 24 days  
Aggregate intrinsic value | $ $ 105,483  
Time-based RSUs and PRSUs    
Activity under the plan    
Granted (in shares) (3,241)  
Cancelled (in shares) 433  
v3.20.2
Stock incentive plans - Summary of RSU activity (Details)
shares in Thousands
 9 Months Ended
Sep. 30, 2020
$ / shares
shares
RSU  
Number of Shares  
Balance at the beginning of the period (in shares) | shares 8,885
Granted (in shares) | shares 4,545
Vested stock units awarded (in shares) | shares (4,803)
Cancelled (in shares) | shares (433)
Balance at the end of the period (in shares) | shares 6,890
Weighted- Average Grant Date Fair Value Per Share  
Balance at the beginning of the period (in dollars per share) | $ / shares $ 15.17
Granted (in dollars per share) | $ / shares 18.53
Vested (in dollars per share) | $ / shares 17.98
Cancelled (in dollars per share) | $ / shares 18.40
Balance at the end of the period (in dollars per share) | $ / shares $ 12.82
Time-based RSUs and PRSUs  
Number of Shares  
Granted and adjusted (in shares) | shares (1,578)
Weighted- Average Grant Date Fair Value Per Share  
Granted (in dollars per share) | $ / shares $ 25.85
PRSU  
Number of Shares  
Granted (in shares) | shares 274
Weighted- Average Grant Date Fair Value Per Share  
Granted (in dollars per share) | $ / shares $ 16.17
v3.20.2
Stock incentive plans - Summary of stock based compensation expense (Details) - USD ($)
$ in Thousands
 3 Months Ended 9 Months Ended
Sep. 30, 2020
Sep. 30, 2019
Sep. 30, 2020
Sep. 30, 2019
Stock-based compensation        
Total stock-based compensation expense $ 21,205 $ 28,286 $ 102,329 $ 47,826
Cost of revenue        
Stock-based compensation        
Total stock-based compensation expense 2,104 822 5,321 3,678
Research and development        
Stock-based compensation        
Total stock-based compensation expense 7,185 22,181 70,954 30,753
Selling and marketing        
Stock-based compensation        
Total stock-based compensation expense 4,078 1,752 9,198 5,909
General and administrative        
Stock-based compensation        
Total stock-based compensation expense $ 7,838 $ 3,531 $ 16,856 $ 7,486
v3.20.2
Net loss per share - Schedule of earnings per share, basic and diluted (Details) - USD ($)
$ / shares in Units, shares in Thousands, $ in Thousands
 3 Months Ended 9 Months Ended
Sep. 30, 2020
Sep. 30, 2019
Sep. 30, 2020
Sep. 30, 2019
Earnings Per Share [Abstract]        
Net loss $ (102,902) $ (78,707) $ (367,832) $ (165,060)
Shares used in computing net loss per share, basic and diluted 132,484 95,577 119,386 88,663
Net loss per share, basic and diluted (in dollars per share) $ (0.78) $ (0.82) $ (3.08) $ (1.86)
v3.20.2
Net loss per share - Schedule of antidilutive securities excluded from computation of earnings per share (Details) - shares
shares in Thousands
 3 Months Ended 9 Months Ended
Sep. 30, 2020
Sep. 30, 2019
Sep. 30, 2020
Sep. 30, 2019
Antidilutive shares excluded from diluted net loss per share        
Total shares of common stock equivalents (in shares) 19,537 15,840 19,864 12,146
Shares of common stock subject to outstanding options        
Antidilutive shares excluded from diluted net loss per share        
Total shares of common stock equivalents (in shares) 3,365 3,647 3,419 3,691
Shares of common stock subject to outstanding warrants        
Antidilutive shares excluded from diluted net loss per share        
Total shares of common stock equivalents (in shares) 330 586 396 596
Shares of common stock subject to outstanding RSUs        
Antidilutive shares excluded from diluted net loss per share        
Total shares of common stock equivalents (in shares) 5,800 5,915 5,589 4,878
Shares of common stock subject to outstanding PRSUs        
Antidilutive shares excluded from diluted net loss per share        
Total shares of common stock equivalents (in shares) 1,531 2,722 1,945 994
Shares of common stock pursuant to ESPP        
Antidilutive shares excluded from diluted net loss per share        
Total shares of common stock equivalents (in shares) 312 229 316 219
Shares of common stock underlying Series A convertible preferred stock        
Antidilutive shares excluded from diluted net loss per share        
Total shares of common stock equivalents (in shares) 125 125 125 896
Shares of common stock subject to convertible senior notes exercise        
Antidilutive shares excluded from diluted net loss per share        
Total shares of common stock equivalents (in shares) 8,074 2,616 8,074 872
v3.20.2
Geographic information - Schedule of revenue by country (Details) - USD ($)
$ in Thousands
 3 Months Ended 9 Months Ended
Sep. 30, 2020
Sep. 30, 2019
Sep. 30, 2020
Sep. 30, 2019
Geographic information        
Total revenue $ 68,728 $ 56,511 $ 179,167 $ 150,539
United States        
Geographic information        
Total revenue 64,322 52,687 167,462 140,700
Canada        
Geographic information        
Total revenue 1,101 1,158 3,117 3,005
Rest of world        
Geographic information        
Total revenue $ 3,305 $ 2,666 $ 8,588 $ 6,834