SCHEDULE 13G
(Rule 13d-102)
Information to be Included in Statements Filed Pursuant to Rule 13d-1(b), (c) and (d) and Amendments Thereto Filed Pursuant to Rule 13d-2.
SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549
Under the Securities Exchange Act of 1934 (Amendment No. 1 )*
Halozyme Therapeutics, Inc.

(Name of Issuer)

Common Stock

(Title of Class of Securities)

40637H109
 (CUSIP Number)

12/31/2020
 (Date of Event Which Requires Filing of this Statement)
Check the appropriate box to designate the rule pursuant to which this Schedule is filed:
[X] Rule 13d-1(b)
[_] Rule 13d-1(c)
[_] Rule 13d-1(d)
* The remainder of this cover page shall be filled out for a reporting person's initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page.
The information required in the remainder of this cover page shall not be deemed to be "filed" for the purpose of Section 18 of the Securities Exchange Act of 1934 ("Act") or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).

CUSIP No.  40637H109                        13G

--------------------------------------------------------------------------------
 1  NAME OF REPORTING PERSON
     Artisan Partners Limited Partnership
--------------------------------------------------------------------------------
 2  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
    (see Instructions)                                                   (a) [_]
                                                                         (b) [_]
     Not Applicable
--------------------------------------------------------------------------------
 3  SEC USE ONLY
--------------------------------------------------------------------------------
 4  CITIZENSHIP OR PLACE OF ORGANIZATION
     Delaware
--------------------------------------------------------------------------------
                5  SOLE VOTING POWER
                    None
 NUMBER OF
   SHARES
BENEFICIALLY    ---------------------------
  OWNED BY      6  SHARED VOTING POWER
    EACH            8,165,901
 REPORTING      ---------------------------
   PERSON       7  SOLE DISPOSITIVE POWER
    WITH            None
                ---------------------------
                8  SHARED DISPOSITIVE POWER
                    10,284,136
--------------------------------------------
 9  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
     10,284,136
--------------------------------------------------------------------------------
10  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES
    (see Instructions)                                                       [_]
     Not Applicable
--------------------------------------------------------------------------------
11  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
     7.6%
--------------------------------------------------------------------------------
12  TYPE OF REPORTING PERSON
    (see Instructions)
     IA	

CUSIP No.  40637H109                        13G

--------------------------------------------------------------------------------
 1  NAME OF REPORTING PERSON
     Artisan Investments GP LLC
--------------------------------------------------------------------------------
 2  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
    (see Instructions)                                                   (a) [_]
                                                                         (b) [_]
     Not Applicable
--------------------------------------------------------------------------------
 3  SEC USE ONLY
--------------------------------------------------------------------------------
 4  CITIZENSHIP OR PLACE OF ORGANIZATION
     Delaware
--------------------------------------------------------------------------------
                5  SOLE VOTING POWER
                    None
 NUMBER OF
   SHARES
BENEFICIALLY    ---------------------------
  OWNED BY      6  SHARED VOTING POWER
    EACH            8,165,901
 REPORTING      ---------------------------
   PERSON       7  SOLE DISPOSITIVE POWER
    WITH            None
                ---------------------------
                8  SHARED DISPOSITIVE POWER
                    10,284,136
--------------------------------------------
 9  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
     10,284,136
--------------------------------------------------------------------------------
10  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES
    (see Instructions)                                                       [_]
     Not Applicable
--------------------------------------------------------------------------------
11  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
     7.6%
--------------------------------------------------------------------------------
12  TYPE OF REPORTING PERSON
    (see Instructions)
     HC	

CUSIP No.  40637H109                        13G

--------------------------------------------------------------------------------
 1  NAME OF REPORTING PERSON
     Artisan Partners Holdings LP
--------------------------------------------------------------------------------
 2  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
    (see Instructions)                                                   (a) [_]
                                                                         (b) [_]
     Not Applicable
--------------------------------------------------------------------------------
 3  SEC USE ONLY
--------------------------------------------------------------------------------
 4  CITIZENSHIP OR PLACE OF ORGANIZATION
     Delaware
--------------------------------------------------------------------------------
                5  SOLE VOTING POWER
                    None
 NUMBER OF
   SHARES
BENEFICIALLY    ---------------------------
  OWNED BY      6  SHARED VOTING POWER
    EACH            8,165,901
 REPORTING      ---------------------------
   PERSON       7  SOLE DISPOSITIVE POWER
    WITH            None
                ---------------------------
                8  SHARED DISPOSITIVE POWER
                    10,284,136
--------------------------------------------
 9  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
     10,284,136
--------------------------------------------------------------------------------
10  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES
    (see Instructions)                                                       [_]
     Not Applicable
--------------------------------------------------------------------------------
11  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
     7.6%
--------------------------------------------------------------------------------
12  TYPE OF REPORTING PERSON
    (see Instructions)
     HC	

CUSIP No.  40637H109                        13G

--------------------------------------------------------------------------------
 1  NAME OF REPORTING PERSON
     Artisan Partners Asset Management Inc.
--------------------------------------------------------------------------------
 2  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
    (see Instructions)                                                   (a) [_]
                                                                         (b) [_]
     Not Applicable
--------------------------------------------------------------------------------
 3  SEC USE ONLY
--------------------------------------------------------------------------------
 4  CITIZENSHIP OR PLACE OF ORGANIZATION
     Delaware
--------------------------------------------------------------------------------
                5  SOLE VOTING POWER
                    None
 NUMBER OF
   SHARES
BENEFICIALLY    ---------------------------
  OWNED BY      6  SHARED VOTING POWER
    EACH            8,165,901
 REPORTING      ---------------------------
   PERSON       7  SOLE DISPOSITIVE POWER
    WITH            None
                ---------------------------
                8  SHARED DISPOSITIVE POWER
                    10,284,136
--------------------------------------------
 9  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
     10,284,136
--------------------------------------------------------------------------------
10  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES
    (see Instructions)                                                       [_]
     Not Applicable
--------------------------------------------------------------------------------
11  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
     7.6%
--------------------------------------------------------------------------------
12  TYPE OF REPORTING PERSON
    (see Instructions)
     HC	

Item 1(a) Name of Issuer:
Halozyme Therapeutics, Inc.
Item 1(b) Address of Issuer's Principal Executive Offices:
11388 Sorrento Valley Road, San Diego, California 92121
Item 2(a) Name of Person Filing:
Artisan Partners Limited Partnership ("APLP") Artisan Investments GP LLC ("Artisan Investments") Artisan Partners Holdings LP ("Artisan Holdings") Artisan Partners Asset Management Inc. ("APAM")
Item 2(b) Address of Principal Business Office:
APLP, Artisan Investments, Artisan Holdings, and APAM are all located at:
875 East Wisconsin Avenue, Suite 800
Milwaukee, WI 53202
Item 2(c) Citizenship:
APLP is a Delaware limited partnership
Artisan Investments is a Delaware limited liability company Artisan Holdings is a Delaware limited partnership APAM is a Delaware corporation
Item 2(d) Title of Class of Securities:
Common Stock
Item 2(e) CUSIP Number:
40637H109
Item 3 Type of Person:
(e) APLP is an investment adviser registered under section 203 of the Investment Advisers Act of 1940.
(g) Artisan Holdings is the sole limited partner of APLP and the sole member of Artisan Investments; Artisan Investments is the general partner of APLP; APAM is the general partner of Artisan Holdings.

Item 4 Ownership (at 12/31/2020):
(a) Amount owned "beneficially" within the meaning of rule 13d-3:
10,284,136
(b) Percent of class:
7.6% (based on 135,183,040 shares outstanding as of 10/28/2020)
(c) Number of shares as to which such person has:
(i) sole power to vote or to direct the vote:
None
(ii) shared power to vote or to direct the vote:
8,165,901
(iii) sole power to dispose or to direct the disposition of:
None
(iv) shared power to dispose or to direct the disposition of:
10,284,136
Item 5 Ownership of Five Percent or Less of a Class:
Not Applicable
Item 6 Ownership of More than Five Percent on Behalf of Another Person:
The shares reported herein have been acquired on behalf of discretionary clients of APLP. Persons other than APLP are entitled to receive all dividends from, and proceeds from the sale of, those shares. None of those persons, to the knowledge of APLP, Artisan Holdings, APAM, or Artisan Investments has an economic interest in more than 5% of the class.
Item 7 Identification and Classification of the Subsidiary Which Acquired
 the Security Being Reported on by the Parent Holding Company or Control Person:
Not Applicable
Item 8 Identification and Classification of Members of the Group:
Not Applicable
Item 9 Notice of Dissolution of Group:
Not Applicable
Item 10 Certification:
By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect.

Signature
After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.
Date: 2/10/2021
ARTISAN PARTNERS ASSET MANAGEMENT
INC,
 for itself and as the general
partner of
ARTISAN PARTNERS HOLDINGS LP
By: Gregory K. Ramirez *
ARTISAN INVESTMENTS GP LLC,
 for itself and as the general
partner of
ARTISAN PARTNERS LIMITED PARTNERSHIP
By: Gregory K. Ramirez *

*By:  /s/ Gregory K. Ramirez
      -------------------------------
      Gregory K. Ramirez
      Executive Vice President of
      Artisan Partners Asset
      Management Inc.
      Vice President of Artisan
      Investments GP LLC	

                                 Exhibit Index

Exhibit 1    Joint Filing Agreement dated 2/10/2021 by and among Artisan
             Partners Limited Partnership, Artisan Investments GP LLC, Artisan
             Partners Holdings LP, and Artisan Partners Asset Management Inc.	

EXHIBIT 1
JOINT FILING AGREEMENT
The undersigned hereby agree to the joint filing of the Schedule 13G to which this Agreement is attached.
Dated: 2/10/2021
ARTISAN PARTNERS ASSET MANAGEMENT INC,
 for itself and as the general partner of
ARTISAN PARTNERS HOLDINGS LP
By: Gregory K. Ramirez *
ARTISAN INVESTMENTS GP LLC,
 for itself and as the general partner of
ARTISAN PARTNERS LIMITED PARTNERSHIP
By: Gregory K. Ramirez *

*By:  /s/ Gregory K. Ramirez
      -----------------------------------
      Gregory K. Ramirez
      Executive Vice President of
        Artisan Partners Asset
        Management Inc.
      Vice President of Artisan
      Investments GP LLC