SECURITIES AND EXCHANGE COMMISSION	
Washington, D.C. 20549	
 	
SCHEDULE 13G	
 	
Under the Securities Exchange Act of 1934	
(Amendment No. )*	
 	
Exact Sciences Corporation	
(Name of Issuer)	
 	
Common Stock, $.01 Par Value	
(Title of Class of Securities)	
 	
30063P105	
(CUSIP Number)	
 	
February 23, 2018	
(Date of Event Which Requires Filing of This Statement)	

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:	
 	
☐	Rule 13d-1(b)	
X	Rule 13d-1(c)	
☐	Rule 13d-1(d)	
 	
(Page 1 of 8 Pages)	

______________________________
*The remainder of this cover page shall be filled out for a reporting person's initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page.
The information required in the remainder of this cover page shall not be deemed to be "filed" for the purpose of Section 18 of the Securities Exchange Act of 1934 ("Act") or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).

 
CUSIP No. 30063P105
 	 
13G	 
Page   2   of 8 Pages	

1	NAME OF REPORTING PERSON
Lone Pine Capital LLC
 	
2	CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP	(a) ☐
(b) ☐	
3	SEC USE ONLY	
4	CITIZENSHIP OR PLACE OF ORGANIZATION
Delaware	
NUMBER OF 
 SHARES 
 BENEFICIALLY 
 OWNED BY 
 EACH 
 REPORTING 
 PERSON WITH:	5	SOLE VOTING POWER
0	
	6	SHARED VOTING POWER

6,395,857 shares of Common Stock	
	7	SOLE DISPOSITIVE POWER
0	
	8	SHARED DISPOSITIVE POWER
6,395,857 shares of Common Stock	
9	AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
6,395,857 shares of Common Stock	
10	CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES	☐	
11	PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
5.3%	
12	TYPE OF REPORTING PERSON
OO	

 
CUSIP No. 30063P105
 	 
13G	 
Page   3   of 8 Pages	

1	NAME OF REPORTING PERSON
Stephen F. Mandel, Jr.
 	
2	CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP	(a) ☐
(b) ☐	
3	SEC USE ONLY	
4	CITIZENSHIP OR PLACE OF ORGANIZATION
United States of America	
NUMBER OF 
 SHARES 
 BENEFICIALLY 
 OWNED BY 
 EACH 
 REPORTING 
 PERSON WITH:	5	SOLE VOTING POWER
0	
	6	SHARED VOTING POWER
6,395,857 shares of Common Stock	
	7	SOLE DISPOSITIVE POWER
0	
	8	SHARED DISPOSITIVE POWER
6,395,857 shares of Common Stock	
9	AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
6,395,857 shares of Common Stock	
10	CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES	☐	
11	PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
5.3%	
12	TYPE OF REPORTING PERSON
IN	

 
CUSIP No. 30063P105
 	 
13G	 
Page 4 of 8 Pages	

 
Item 1 (a).	NAME OF ISSUER	
 	Exact Sciences Corporation (the "Issuer")	

Item 1(b).	ADDRESS OF ISSUER'S PRINCIPAL EXECUTIVE OFFICES	
 	441 Charmany Drive	
 	Madison, WI 53719	

Item 2 (a).	NAME OF PERSON FILING	
 	This statement is filed by:
 
Lone Pine Capital LLC, a Delaware limited liability company ("Lone Pine Capital"), which serves as investment manager to Lone Spruce, L.P., a Delaware limited partnership ("Lone Spruce"), Lone Cascade, L.P., a Delaware limited partnership ("Lone Cascade"), Lone Sierra, L.P., a Delaware limited partnership ("Lone Sierra"), Lone Tamarack, L.P., a Delaware limited partnership ("Lone Tamarack"), Lone Cypress, Ltd., a Cayman Islands exempted company ("Lone Cypress"), Lone Kauri, Ltd., a Cayman Islands exempted company ("Lone Kauri"), Lone Monterey Master Fund, Ltd., a Cayman Islands exempted company ("Lone Monterey Master Fund"),  and Lone Savin Master Fund, Ltd., a Cayman Islands exempted company ("Lone Savin Master Fund", and together with Lone Spruce, Lone Cascade, Lone Sierra, Lone Tamarack, Lone Cypress, Lone Kauri, Lone Monterey Master Fund and Lone Savin Master Fund, the "Lone Pine Funds"), with respect to the Common Stock directly held by each of the Lone Pine Funds; and
 
Stephen F. Mandel, Jr. ("Mr. Mandel"), the managing member of Lone Pine Managing Member LLC, which is the Managing Member of Lone Pine Capital, with respect to the Common Stock directly held by each of the Lone Pine Funds.
 
The foregoing persons are hereinafter sometimes collectively referred to as the "Reporting Persons".  Any disclosures herein with respect to persons other than the Reporting Persons are made on information and belief after making inquiry to the appropriate party.	

Item 2(b).	ADDRESS OF PRINCIPAL BUSINESS OFFICE OR, IF NONE, RESIDENCE	
 	The address of the business office of each of the Reporting Persons is Two Greenwich Plaza, Greenwich, Connecticut 06830.	

 
Item 2(c).	CITIZENSHIP 	
 	Lone Pine Capital is a limited liability company organized under the laws of the State of Delaware.  Mr. Mandel is a United States citizen. 	

Item 2(d).	TITLE OF CLASS OF SECURITIES 	
 	Common Stock, $.01 Par Value (the "Common Stock")	

  Item 2(e).	CUSIP NUMBER 	
 	30063P105  	

 
CUSIP No. 30063P105
 	 
13G	 
Page   5   of 8 Pages	
 
Item 3.	IF THIS STATEMENT IS FILED PURSUANT TO Rules 13d-1(b), OR 13d-2(b) OR (c), CHECK WHETHER THE PERSON FILING IS A:	

 	(a)	☐	Broker or dealer registered under Section 15 of the Act;	
 	(b)	☐	Bank as defined in Section 3(a)(6) of the Act;	
 	(c)	☐	Insurance company as defined in Section 3(a)(19) of the Act;	
 	(d)	☐	Investment company registered under Section 8 of the Investment Company Act of 1940;	
 	(e)	☐	An investment adviser in accordance with Rule 13d-1(b)(1)(ii)(E);	
 	(f)	☐	An employee benefit plan or endowment fund in accordance with Rule 13d-1(b)(1)(ii)(F);
 	
 	(g)	☐	A parent holding company or control person in accordance with Rule 13d-1(b)(1)(ii)(G);	
 	(h)	☐	A savings association as defined in Section 3(b) of the Federal Deposit Insurance Act;
 	
 	(i)	☐	A church plan that is excluded from the definition of an investment company under Section 3(c)(14) of the Investment Company Act;
 	
 	(j)	☐	A non-U.S. institution in accordance with Rule 13d-1(b)(1)(ii)(J);	
 	(k)	☐	Group, in accordance with Rule 13d-1(b)(1)(ii)(K).	

 	If filing as a non-U.S. institution in accordance with Rule 13d-1(b)(1)(ii)(J), please specify the type of institution: ____________________

Item 4.	OWNERSHIP	

A.  Lone Pine Capital LLC and Stephen F. Mandel, Jr.
 
(a) Amount beneficially owned: 6,395,857 shares of Common Stock
(b) Percent of class: 5.3%.  The percentages set forth in this Item 4 and in the rest of this Schedule 13G are based upon a total of 120,941,528 shares of Common Stock reported to be outstanding by the Issuer as of February 20, 2018 in its Annual Report on Form 10-K filed on February 22, 2018.
(c)(i) Sole power to vote or direct the vote: -0-
(ii) Shared power to vote or direct the vote: 6,395,857 shares of Common Stock
(iii) Sole power to dispose or direct the disposition: -0-
(iv) Shared power to dispose or direct the disposition: 6,395,857 shares of Common Stock

 
CUSIP No. 30063P105
 	 
13G	 
Page   6   of 8 Pages	

 	 	

Item 5.	OWNERSHIP OF FIVE PERCENT OR LESS OF A CLASS	
 	 	
 	Not applicable.	

Item 6.	OWNERSHIP OF MORE THAN FIVE PERCENT ON BEHALF OF ANOTHER PERSON	
 	 
Not applicable.	

Item 7.	IDENTIFICATION AND CLASSIFICATION OF THE SUBSIDIARY WHICH ACQUIRED THE SECURITY BEING REPORTED ON BY THE PARENT HOLDING COMPANY OR CONTROL PERSON	
 	Not applicable	

Item 8.	IDENTIFICATION AND CLASSIFICATION OF MEMBERS OF THE GROUP	
 	Not applicable	

Item 9.	NOTICE OF DISSOLUTION OF GROUP	
 	Not applicable	

Item 10.	CERTIFICATION	

 	Each of the Reporting Persons hereby makes the following certification:	

 	By signing below each Reporting Person certifies that, to the best of his or its knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect.	

 
CUSIP No. 30063P105	 
13G	 
Page   7   of 8 Pages

 
SIGNATURES
After reasonable inquiry and to the best of his or its knowledge and belief, each of the undersigned certifies that the information set forth in this statement is true, complete and correct.
DATE:  March 5, 2018

 	 	 	
 	 	By:   /s/ Stephen F. Mandel, Jr.	
 	 	Stephen F. Mandel, Jr., individually and as	
 	 	Managing Member of Lone Pine Managing Member LLC,  as Managing Member of Lone Pine Capital LLC	

 	 	 	

 
CUSIP No. 30063P105
 	 
13G	Page   8   of 8 Pages	

EXHIBIT 1
JOINT FILING AGREEMENT 
 PURSUANT TO RULE 13d-1(k)
The undersigned acknowledge and agree that the foregoing statement on Schedule 13G is filed on behalf of each of the undersigned and that all subsequent amendments to this statement on Schedule 13G shall be filed on behalf of each of the undersigned without the necessity of filing additional joint filing agreements.  The undersigned acknowledge that each shall be responsible for the timely filing of such amendments, and for the completeness and accuracy of the information concerning him or it contained herein and therein, but shall not be responsible for the completeness and accuracy of the information concerning the others, except to the extent that he or it knows or has reason to believe that such information is inaccurate.
DATE:  March 5, 2018

 	 	 	
 	 	By:   /s/ Stephen F. Mandel, Jr.	
 	 	Stephen F. Mandel, Jr., individually and as	
 	 	Managing Member of Lone Pine Managing Member LLC,  as Managing Member of Lone Pine Capital LLC