FORM 3
        	UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES
	OMB APPROVAL
OMB Number: 3235-0104
Estimated average burden
hours per response... 0.5	
                      	Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940	                      	

1. Name and Address of Reporting Person *

Baranick Brian	2. Date of Event Requiring Statement (MM/DD/YYYY)
8/4/2022 
	3. Issuer Name and Ticker or Trading Symbol

EXACT SCIENCES CORP [EXAS]	
(Last)        (First)        (Middle)

5505 ENDEAVOR LANE	4. Relationship of Reporting Person(s) to Issuer (Check all applicable)

_____ Director                          _____ 10% Owner
___X___ Officer (give title below)        _____ Other (specify below)
Gen. Mgr., Precision Oncology /	
(Street)

MADISON, WI 53719      

(City)              (State)              (Zip)	5. If Amendment, Date Original Filed(MM/DD/YYYY)
 
	6. Individual or Joint/Group Filing(Check Applicable Line)

_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person	

Table I - Non-Derivative Securities Beneficially Owned	
1.Title of Security
(Instr. 4)	2. Amount of Securities Beneficially Owned
(Instr. 4)	3. Ownership Form: Direct (D) or Indirect (I)
(Instr. 5)	4. Nature of Indirect Beneficial Ownership
(Instr. 5)	
Common Stock 	2868 	D 	 	
Common Stock 	159 	I 	Held in 401(k) Plan 	

Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)	
1. Title of Derivate Security
(Instr. 4)	2. Date Exercisable and Expiration Date
(MM/DD/YYYY)	3. Title and Amount of Securities Underlying Derivative Security
(Instr. 4)	4. Conversion or Exercise Price of Derivative Security	5. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 5)	6. Nature of Indirect Beneficial Ownership
(Instr. 5)	
	Date Exercisable	Expiration Date	Title	Amount or Number of Shares				
Restricted Stock Units 	 (1)	 (1)	Common Stock 	8136 	 (2)	D 	 	
Restricted Stock Units 	 (3)	 (3)	Common Stock 	5187 	 (2)	D 	 	
Restricted Stock Units 	 (4)	 (4)	Common Stock 	15817 	 (2)	D 	 	

Explanation of Responses:	
(1) 	Represents a restricted stock unit award that vests in three equal annual installments beginning on August 4, 2022.	
(2) 	Each restricted stock unit represents a contingent right to receive one share of common stock.	
(3) 	Represents a restricted stock unit award that vests in three equal annual installments beginning on February 19, 2023.	
(4) 	Represents a restricted stock unit award that vests in four equal annual installments beginning on February 25, 2023.	

Reporting Owners	
Reporting Owner Name / Address	Relationships	
	Director	10% Owner	Officer	Other	
Baranick Brian
5505 ENDEAVOR LANE
MADISON, WI 53719			Gen. Mgr., Precision Oncology		

Signatures		
/s/ Brian Baranick by Mark R. Busch, attorney-in-fact		8/8/2022	
**Signature of Reporting Person		Date

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.	
*	If the form is filed by more than one reporting person, see Instruction 5(b)(v).	
**	Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).	
Note:	File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.	
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB control number.