Form 144 Filer Information	UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

Form 144

NOTICE OF PROPOSED SALE OF SECURITIES
PURSUANT TO RULE 144 UNDER THE SECURITIES ACT OF 1933	
Form 144		
144: Issuer Information

Name of Issuer	EXACT SCIENCES CORP	
SEC File Number	001-35092	
Address of Issuer	5505 ENDEAVOR LANE
MADISON
WISCONSIN
53719	
Phone	608-284-5700	
Name of Person for Whose Account the Securities are To Be Sold	Condella Sarah	
See the definition of "person" in paragraph (a) of Rule 144. Information is to be given not only as to the person for whose account the securities are to be sold but also as to all other persons included in that definition. In addition, information shall be given as to sales by all persons whose sales are required by paragraph (e) of Rule 144 to be aggregated with sales for the account of the person filing this notice.	
Relationship to Issuer	1.	Officer	
144: Securities Information

Record	Title of the Class of Securities To Be Sold	Name and Address of the Broker	Number of Shares or Other Units To Be Sold	Aggregate Market Value	Number of Shares or Other Units Outstanding	Approximate Date of Sale	Name the Securities Exchange	
#1	Common	Fidelity Brokerage Services LLC
900 Salem Street
Smithfield
RHODE ISLAND
02917	2,924	$178,717.22	178,217,142	02/28/2023	NASDAQ	

144: Securities To Be Sold

Furnish the following information with respect to the acquisition of the securities to be sold and with respect to the payment of all or any part of the purchase price or other consideration therefor:	

Record	Title of the Class	Date you Acquired	Nature of Acquisition Transaction	Name of Person from Whom Acquired	Is this a Gift?	Date Donor Acquired	Amount of Securities Acquired	Date of Payment	Nature of Payment *	
#1	Common	02/27/2023	Restricted Stock Vesting	Issuer	☐	—	2,924	02/27/2023	Compensation	

* If the securities were purchased and full payment therefor was not made in cash at the time of purchase, explain in the table or in a note thereto the nature of the consideration given. If the consideration consisted of any note or other obligation, or if payment was made in installments describe the arrangement and state when the note or other obligation was discharged in full or the last installment paid.	
144: Securities Sold During The Past 3 Months

Furnish the following information as to all securities of the issuer sold during the past 3 months by the person for whose account the securities are to be sold.	

Record	Name and Address of Seller	Title of Securities Sold	Date of Sale	Amount of Securities Sold	Gross Proceeds	
#1	Sarah Condella
5505 Endeavor Lane
Madison
WISCONSIN
53719	Common	01/09/2023	1,000	$60,000.00	
#2	Sarah Condella
5505 Endeavor Lane
Madison
WISCONSIN
53719	Common	02/01/2023	1,000	$67,930.00	
#3	Sarah Condella
5505 Endeavor Lane
Madison
WISCONSIN
53719	Common	02/15/2023	954	$62,575.44	
#4	Sarah Condella
5505 Endeavor Lane
Madison
WISCONSIN
53719	Common	02/16/2023	1,076	$68,767.16	
#5	Sarah Condella
5505 Endeavor Lane
Madison
WISCONSIN
53719	Common	02/22/2023	1,033	$64,784.29	

144: Remarks and Signature

Remarks		
Date of Notice	02/28/2023	
ATTENTION:	
The person for whose account the securities to which this notice relates are to be sold hereby represents by signing this notice that he does not know any material adverse information in regard to the current and prospective operations of the Issuer of the securities to be sold which has not been publicly disclosed. If such person has adopted a written trading plan or given trading instructions to satisfy Rule 10b5-1 under the Exchange Act, by signing the form and indicating the date that the plan was adopted or the instruction given, that person makes such representation as of the plan adoption or instruction date.	
Signature	/s/ Ryan Riviere, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Sarah K. Condella	
ATTENTION: Intentional misstatements or omission of facts constitute Federal Criminal Violations (See 18 U.S.C. 1001)