ILLUMINA, INC., 10-K filed on 2/18/2022
Annual Report
v3.22.0.1
Cover Page - USD ($)
shares in Millions, $ in Billions
12 Months Ended
Jan. 02, 2022
Feb. 11, 2022
Jul. 02, 2021
Cover [Abstract]      
Document Type 10-K    
Document Annual Report true    
Document Period End Date Jan. 02, 2022    
Current Fiscal Year End Date --01-02    
Document Transition Report false    
Entity File Number 001-35406    
Entity Registrant Name Illumina, Inc.    
Entity Incorporation, State or Country Code DE    
Entity Tax Identification Number 33-0804655    
Entity Address, Address Line One 5200 Illumina Way    
Entity Address, City or Town San Diego    
Entity Address, State or Province CA    
Entity Address, Postal Zip Code 92122    
City Area Code 858    
Local Phone Number 202-4500    
Title of 12(b) Security Common Stock, $0.01 par value    
Trading Symbol ILMN    
Security Exchange Name NASDAQ    
Entity Well-known Seasoned Issuer Yes    
Entity Voluntary Filers No    
Entity Current Reporting Status Yes    
Entity Interactive Data Current Yes    
Entity Filer Category Large Accelerated Filer    
Entity Small Business false    
Entity Emerging Growth Company false    
ICFR Auditor Attestation Flag true    
Entity Shell Company false    
Entity Common Stock, Shares Outstanding   157.0  
Entity Public Float     $ 60.2
Documents Incorporated by Reference Portions of the registrant’s definitive proxy statement for the 2022 annual meeting of stockholders are incorporated by reference into Items 10 through 14 of Part III of this Report.    
Entity Central Index Key 0001110803    
Document Fiscal Year Focus 2021    
Document Fiscal Period Focus FY    
Amendment Flag false    
v3.22.0.1
Audit Information
12 Months Ended
Jan. 02, 2022
Audit Information [Abstract]  
Auditor Name Ernst & Young LLP
Auditor Location San Diego, California
Auditor Firm ID 42
v3.22.0.1
Consolidated Balance Sheets - USD ($)
$ in Millions
Jan. 02, 2022
Jan. 03, 2021
Current assets:    
Cash and cash equivalents $ 1,232 $ 1,810
Short-term investments 107 1,662
Accounts receivable, net 648 487
Inventory 431 372
Prepaid expenses and other current assets 295 152
Total current assets 2,713 4,483
Property and equipment, net 1,024 922
Operating lease right-of-use assets 672 532
Goodwill 7,113 897
Intangible assets, net 3,250 142
Other assets 445 609
Total assets 15,217 7,585
Current liabilities:    
Accounts payable 332 192
Accrued liabilities 761 541
Convertible senior notes, current portion 0 511
Total current liabilities 1,093 1,244
Operating lease liabilities 774 671
Term notes 993 0
Convertible senior notes 702 673
Other long-term liabilities 915 303
Commitments and contingencies
Stockholders’ equity:    
Preferred stock, $0.01 par value, 10 million shares authorized; no shares issued and outstanding at January 2, 2022 and January 3, 2021 0 0
Common stock, $0.01 par value, 320 million shares authorized; 197 million shares issued and 157 million outstanding at January 2, 2022; 195 million shares issued and 146 million outstanding at January 3, 2021 2 2
Additional paid-in capital 8,938 3,815
Accumulated other comprehensive income 17 2
Retained earnings 5,485 4,723
Treasury stock, 40 million shares and 49 million shares at cost at January 2, 2022 and January 3, 2021, respectively (3,702) (3,848)
Total stockholders’ equity 10,740 4,694
Total liabilities and stockholders’ equity $ 15,217 $ 7,585
v3.22.0.1
Consolidated Balance Sheets (Parenthetical) - $ / shares
Jan. 02, 2022
Jan. 03, 2021
Statement of Financial Position [Abstract]    
Preferred stock, par value (in dollars per share) $ 0.01 $ 0.01
Preferred stock, shares authorized (in shares) 10,000,000 10,000,000
Preferred stock, shares issued (in shares) 0 0
Preferred stock, shares outstanding (in shares) 0 0
Common stock, par value (in dollars per share) $ 0.01 $ 0.01
Common stock, shares authorized (in shares) 320,000,000 320,000,000
Common stock, shares issued (in shares) 197,000,000 195,000,000
Common stock, shares outstanding (in shares) 157,000,000 146,000,000
Treasury stock, shares (in shares) 40,000,000 49,000,000
v3.22.0.1
Consolidated Statements of Income - USD ($)
shares in Millions, $ in Millions
12 Months Ended
Jan. 02, 2022
Jan. 03, 2021
Dec. 29, 2019
Revenue:      
Total revenue $ 4,526 $ 3,239 $ 3,543
Cost of revenue:      
Amortization of acquired intangible assets 71 28 34
Total cost of revenue 1,372 1,036 1,076
Gross profit 3,154 2,203 2,467
Operating expense:      
Research and development 1,185 682 647
Selling, general and administrative 2,092 941 835
Total operating expense 3,277 1,623 1,482
(Loss) income from operations (123) 580 985
Other income (expense):      
Interest income 0 41 75
Interest expense (61) (49) (52)
Other income, net 1,068 284 110
Total other income, net 1,007 276 133
Income before income taxes 884 856 1,118
Provision for income taxes 122 200 128
Consolidated net income 762 656 990
Add: Net loss attributable to noncontrolling interests 0 0 12
Net income attributable to Illumina stockholders $ 762 $ 656 $ 1,002
Earnings per share attributable to Illumina stockholders:      
Basic (in dollars per share) $ 5.07 $ 4.48 $ 6.81
Diluted (in dollars per share) $ 5.04 $ 4.45 $ 6.74
Shares used in computing earnings per share:      
Basic (in shares) 150 147 147
Diluted (in shares) 151 148 149
Product revenue      
Revenue:      
Total revenue $ 3,968 $ 2,735 $ 2,929
Cost of revenue:      
Cost of revenue 1,060 788 802
Service and other revenue      
Revenue:      
Total revenue 558 504 614
Cost of revenue:      
Cost of revenue $ 241 $ 220 $ 240
v3.22.0.1
Consolidated Statements of Comprehensive Income - USD ($)
$ in Millions
12 Months Ended
Jan. 02, 2022
Jan. 03, 2021
Dec. 29, 2019
Statement of Comprehensive Income [Abstract]      
Consolidated net income $ 762 $ 656 $ 990
Unrealized (loss) gain on available-for-sale debt securities, net of deferred tax (1) (3) 6
Unrealized gain on cash flow hedges, net of deferred tax 16 0 0
Total consolidated comprehensive income 777 653 996
Add: Comprehensive loss attributable to noncontrolling interests 0 0 12
Comprehensive income attributable to Illumina stockholders $ 777 $ 653 $ 1,008
v3.22.0.1
Consolidated Statements of Stockholders' Equity - USD ($)
shares in Millions, $ in Millions
Total
Cumulative Effect, Period of Adoption, Adjustment
Common Stock
Additional Paid-In Capital
Accumulated Other Comprehensive (Loss) Income
Retained Earnings
Retained Earnings
Cumulative Effect, Period of Adoption, Adjustment
Treasury Stock
Noncontrolling Interests
Beginning balance (in shares) at Dec. 30, 2018     192         45  
Beginning balance at Dec. 30, 2018 $ 3,845 $ (18) $ 2 $ 3,290 $ (1) $ 3,083 $ (18) $ (2,616) $ 87
Increase (Decrease) in Stockholders' Equity [Roll Forward]                  
Net income (loss) 999         1,002     (3)
Unrealized (loss) gain on available-for-sale debt securities, net of deferred tax 6       6        
Unrealized gain on cash flow hedges, net of deferred tax 0                
Issuance of common stock, net of repurchases (in shares)     2         2  
Issuance of common stock, net of repurchases (346)     59       $ (405)  
Share-based compensation 194     194          
Adjustment to the carrying value of redeemable noncontrolling interests 16     16          
Deconsolidation of Helix (82)     2         (84)
Vesting of redeemable equity awards (1)     (1)          
Ending balance (in shares) at Dec. 29, 2019     194         47  
Ending balance at Dec. 29, 2019 4,613   $ 2 3,560 5 4,067   $ (3,021) 0
Increase (Decrease) in Stockholders' Equity [Roll Forward]                  
Net income (loss) 656         656      
Unrealized (loss) gain on available-for-sale debt securities, net of deferred tax (3)       (3)        
Unrealized gain on cash flow hedges, net of deferred tax 0                
Issuance of common stock, net of repurchases (in shares)     1         2  
Issuance of common stock, net of repurchases (766)     61       $ (827)  
Share-based compensation 194     194          
Ending balance (in shares) at Jan. 03, 2021     195         49  
Ending balance at Jan. 03, 2021 4,694   $ 2 3,815 2 4,723   $ (3,848) 0
Increase (Decrease) in Stockholders' Equity [Roll Forward]                  
Net income (loss) 762         762      
Unrealized (loss) gain on available-for-sale debt securities, net of deferred tax (1)       (1)        
Unrealized gain on cash flow hedges, net of deferred tax 16       16        
Issuance of common stock, net of repurchases (in shares)     2         1  
Issuance of common stock, net of repurchases (31)     60       $ (91)  
GRAIL acquisition (in shares)               10  
GRAIL acquisition 4,986     4,749       $ 237  
Exchange of GRAIL contingent value rights 2     2          
Share-based compensation 312     312          
Ending balance (in shares) at Jan. 02, 2022     197         40  
Ending balance at Jan. 02, 2022 $ 10,740   $ 2 $ 8,938 $ 17 $ 5,485   $ (3,702) $ 0
v3.22.0.1
Consolidated Statements of Cash Flows - USD ($)
$ in Millions
12 Months Ended
Jan. 02, 2022
Jan. 03, 2021
Dec. 29, 2019
Cash flows from operating activities:      
Consolidated net income $ 762 $ 656 $ 990
Adjustments to reconcile net income to net cash provided by operating activities:      
Depreciation expense 176 156 151
Amortization of intangible assets 75 31 37
Share-based compensation expense 754 194 194
Accretion of debt discount on convertible senior notes 32 40 46
Deferred income taxes (76) 117 11
Gain on previously held investment in GRAIL (899) 0 0
Gain on exchange of GRAIL contingent value rights (86) 0 0
Payment of accreted debt discount on convertible senior notes 0 0 (84)
Gains on strategic investments, net (18) (291) (62)
(Gain) loss on Helix contingent value right (30) (7) 1
Gains on deconsolidations 0 0 (54)
(Gain) loss on derivative assets related to terminated acquisition (26) 116 8
Change in fair value of contingent consideration liabilities 4 0 0
Other 29 (5) 7
Changes in operating assets and liabilities:      
Accounts receivable (164) 89 (58)
Inventory (58) (12) 25
Prepaid expenses and other current assets (64) (20) (14)
Operating lease right-of-use assets and liabilities, net (13) (11) (5)
Other assets (27) (33) (30)
Accounts payable 60 40 (35)
Accrued liabilities 101 (7) (44)
Other long-term liabilities 13 27 (33)
Net cash provided by operating activities 545 1,080 1,051
Cash flows from investing activities:      
Maturities of available-for-sale securities 331 493 1,387
Purchases of available-for-sale securities (77) (1,802) (1,010)
Sales of available-for-sale securities 1,031 1,298 629
Purchases of property and equipment (208) (189) (209)
Purchases of strategic investments (52) (124) (20)
Sales of strategic investments 298 0 0
Cash received (paid for) derivative assets related to terminated acquisition 52 (132) (18)
Deconsolidation of Helix cash 0 0 (29)
Proceeds from the deconsolidation of GRAIL 0 0 15
Net cash paid for acquisitions (2,444) (98) 0
Net cash (used in) provided by investing activities (1,069) (554) 745
Cash flows from financing activities:      
Payments on convertible senior notes (517) 0 (550)
Payments on contingent consideration liabilities (71) 0 0
Net proceeds from issuance of debt 988 0 0
Common stock repurchases 0 (736) (324)
Proceeds from issuance of common stock 60 61 59
Taxes paid related to net share settlement of equity awards (511) (91) (82)
Net cash used in financing activities (51) (766) (897)
Effect of exchange rate changes on cash and cash equivalents (3) 8 (1)
Net (decrease) increase in cash and cash equivalents (578) (232) 898
Cash and cash equivalents at beginning of year 1,810 2,042 1,144
Cash and cash equivalents at end of year 1,232 1,810 2,042
Supplemental cash flow information:      
Cash paid for income taxes 233 119 164
Cash paid for operating lease liabilities $ 96 $ 86 $ 84
v3.22.0.1
Organization and Significant Accounting Policies
12 Months Ended
Jan. 02, 2022
Accounting Policies [Abstract]  
Organization and Significant Accounting Policies
1. ORGANIZATION AND SIGNIFICANT ACCOUNTING POLICIES
Business Overview

We are a provider of sequencing- and array-based solutions, serving customers in the research, clinical and applied markets.  Our products are used for applications in the life sciences, oncology, reproductive health, agriculture and other emerging segments. Our customers include leading genomic research centers, academic institutions, government laboratories, and hospitals, as well as pharmaceutical, biotechnology, commercial molecular diagnostic laboratories, and consumer genomics companies.

On August 18, 2021, we acquired GRAIL, a healthcare company focused on early detection of multiple cancers. GRAIL’s Galleri blood test detects various types of cancers before they are symptomatic. GRAIL is currently being held and operated as a separate company, with oversight provided by an appointed, independent monitoring trustee during the European Commission’s ongoing merger review. Refer to note “4. Acquisitions, Goodwill and Intangible Assets” and note “8. Legal Proceedings” for additional details.

Basis of Presentation

The consolidated financial statements have been prepared in conformity with U.S. generally accepted accounting principles and include our accounts, our wholly-owned subsidiaries, majority-owned or controlled companies, and variable interest entities for which we are the primary beneficiary. All intercompany transactions and balances have been eliminated in consolidation. Certain prior period amounts have been reclassified to conform to the current period presentation. We have included the results of operations for GRAIL in our consolidated statements of operations from the date of acquisition. GRAIL operates as a separate reportable segment. See note “11. Segments and Geographic Data” for additional information.

Variable Interest Entities (VIEs)

We evaluate our ownership, contractual and other interests in entities that are not wholly-owned to determine if these entities are VIEs, and, if so, whether we are the primary beneficiary of the VIE. In determining whether we are the primary beneficiary of a VIE and therefore required to consolidate the VIE, we apply a qualitative approach that determines whether we have both (1) the power to direct the activities of the VIE that most significantly impact the VIE’s economic performance and (2) the obligation to absorb losses of, or the rights to receive benefits from, the VIE that could potentially be significant to that VIE. We continuously perform this assessment, as changes to existing relationships or future transactions may result in the consolidation or deconsolidation of a VIE. See note “3. Investments and Fair Value Measurements” for further details.

Use of Estimates

The preparation of the consolidated financial statements requires that management make estimates and assumptions that affect the reported amounts of assets, liabilities, revenues, expenses, and related disclosures of contingent assets and liabilities. Though the impact of the COVID-19 pandemic to our business and operating results presents additional uncertainty, we continue to use the best information available to inform our critical accounting estimates. Actual results could differ from those estimates.

Fiscal Year

Our fiscal year is the 52 or 53 weeks ending the Sunday closest to December 31, with quarters of 13 or 14 weeks ending the Sunday closest to March 31, June 30, September 30, and December 31. References to 2021, 2020, and 2019 refer to fiscal years ended January 2, 2022, January 3, 2021, and December 29, 2019, respectively. Fiscal years 2021 and 2019 were both 52 weeks, and fiscal year 2020 was 53 weeks.
Functional Currency

The U.S. dollar is the functional currency of our international operations. We re-measure foreign subsidiaries’ monetary assets and liabilities to the U.S. dollar and record the net gains or losses resulting from re-measurement in other income, net in the consolidated statements of income.

Concentrations of Risk

Customers

We operate in markets that are highly competitive and rapidly changing. Significant technological changes, shifting customer needs, the emergence of competitive products or services with new capabilities, and other factors could negatively impact our operating results. A portion of our customers consist of university and research institutions that management believes are, to some degree, directly or indirectly supported by the United States Government. A significant change in current research funding, particularly with respect to the U.S. National Institutes of Health, could have an adverse impact on future revenues and results of operations.

International sales entail a variety of risks, including currency exchange fluctuations, longer payment cycles, and greater difficulty in accounts receivable collection. We are also subject to general geopolitical risks, such as political, social and economic instability, and changes in diplomatic and trade relations. The risks of international sales are mitigated in part by the extent to which sales are geographically distributed. Shipments to customers outside the United States comprised 52%, 49%, and 48% of total revenue in 2021, 2020, and 2019, respectively. Customers outside the United States represented 57% and 56% of our gross trade accounts receivable balance as of January 2, 2022 and January 3, 2021, respectively.

We had no customers that provided more than 10% of total revenue in 2021, 2020, and 2019. We perform regular reviews of customer activity and associated credit risks and do not require collateral or enter into netting arrangements. Historically, we have not experienced significant credit losses from accounts receivable.

Financial Instruments

We are also subject to risks related to our financial instruments, including cash and cash equivalents, investments, and accounts receivable. Most of our cash and cash equivalents as of January 2, 2022 were deposited with U.S. financial institutions, either domestically or with their foreign branches. Our investment policy restricts the amount of credit exposure to any one issuer to 5% of the portfolio or 5% of the total issue size outstanding at the time of purchase and to any one industry sector, as defined by Clearwater Analytics (Industry Sector Report), to 30% of the portfolio at the time of purchase. There is no limit to the percentage of the portfolio that may be maintained in debt securities, U.S. government-sponsored entities, U.S. Treasury securities, and money market funds. Historically, we have not experienced significant credit losses from financial instruments.

Suppliers

We require customized products and components that currently are available from a limited number of sources. We source certain key products and components included in our products from single vendors.

Segments

We report segment information based on the management approach. This approach designates the internal reporting used by the Chief Operating Decision Maker (CODM) for making decisions and assessing performance as the source of our reportable segments. The CODM allocates resources and assesses the performance of each operating segment using information about its revenue and income (loss) from operations. Management evaluates the performance of our reportable segments based upon income (loss) from operations. We do not allocate expenses between segments.
Accounting Pronouncements Adopted in 2020

In May 2020, the SEC issued Final Rule Release No. 33-10786, Amendments to Financial Disclosures about Acquired and Disposed Businesses, which amends the disclosure requirements applicable to acquisitions and dispositions of businesses, including the required pro forma financial information. Among other changes, the final amendments revised the investment and income tests used to determine whether a business acquisition is significant and reduced the filing requirements for financial statements and pro forma financial information of a significant acquired business to cover a maximum of two years. We adopted the amendments in 2020 in connection with our acquisition of GRAIL, which is further described in note “4. Acquisitions, Goodwill and Intangible Assets.”

In June 2016, the FASB issued ASU 2016-13, Financial Instruments - Credit Losses: Measurement of Credit Losses on Financial Instruments, which amends the impairment model by requiring entities to use a forward-looking approach based on expected losses to estimate credit losses on certain types of financial instruments, including trade receivables and available-for-sale debt securities. We adopted the standard on its effective date in the first quarter of 2020 using a modified retrospective approach. The cumulative effect of applying the new credit loss standard was not material and, therefore, did not result in an adjustment to retained earnings. There was no material difference to the consolidated financial statements in 2020 due to the adoption of ASU 2016-13.

In accordance with ASU 2016-13, we no longer evaluate whether our available-for-sale debt securities in an unrealized loss position are other than temporarily impaired. Instead, we assess whether such unrealized loss positions are credit-related. The credit-related portion of unrealized losses, and any subsequent improvements, are recorded in interest income through an allowance account. Unrealized gains and losses that are not credit-related are included in accumulated other comprehensive income. We estimate our allowance for credit losses on our trade receivables as described in our Accounts Receivable policy, below.

Accounting Pronouncements Adopted in 2019

In February 2016, the FASB issued ASU 2016-02, Leases (Topic 842), which requires lessees to recognize most leases on the balance sheet as lease liabilities with corresponding right-of-use assets and to disclose key information about leasing arrangements. We adopted Topic 842 on its effective date in the first quarter of 2019 using a modified retrospective approach by recognizing a cumulative-effect adjustment to retained earnings as of December 31, 2018. We elected the available package of practical expedients upon adoption, which allowed us to carry forward our historical assessment of whether existing agreements contained a lease and the classification of our existing operating leases. The impact from adoption primarily resulted in the recognition of operating lease liabilities with corresponding right-of-use assets based on the present value of our remaining minimum lease payments, and the derecognition of existing fixed assets and financing obligations related to build-to-suit leasing arrangements that, under Topic 840, did not qualify for sale-leaseback accounting. We recorded a cumulative-effect adjustment to decrease retained earnings by $18 million, net of deferred tax, upon adoption on December 31, 2018.

Accounting Pronouncements Pending Adoption

In August 2020, the FASB issued ASU 2020-06, Debt - Debt with Conversion and Other Options (Subtopic 470-20) and Derivatives and Hedging - Contracts in Entity’s Own Equity (Subtopic 815-40). The new standard reduces the number of accounting models for convertible debt instruments, amends the accounting for certain contracts in an entity’s own equity, and modifies how certain convertible instruments and contracts that may be settled in cash or shares impact the calculation of diluted EPS. Specifically, the guidance removes certain accounting models that separate the embedded conversion features from the host contract for convertible instruments. The standard is effective for us beginning in the first quarter of 2022 and will be adopted using a modified retrospective approach by recognizing a cumulative-effect adjustment to the opening balance of retained earnings on January 3, 2022. We will continue to report financial information for fiscal years ending before January 3, 2022 under the current accounting guidance. As a result of the adoption, we expect to increase our convertible debt liabilities and retained earnings, on January 3, 2022, by approximately $43 million and $61 million, respectively, and decrease our deferred tax liabilities, included in other long-term liabilities on the consolidated balance sheets, and additional paid-in capital by approximately $11 million and $93 million, respectively.
Revenue Recognition

Our revenue is generated primarily from the sale of products and services. Product revenue primarily consists of sales of instruments and consumables used in genetic analysis. Service and other revenue primarily consists of revenue generated from genotyping and sequencing services, instrument service contracts, development and licensing agreements, and cancer detection testing services related to the GRAIL business.

We recognize revenue when control of our products and services is transferred to our customers in an amount that reflects the consideration we expect to receive from our customers in exchange for those products and services. This process involves identifying the contract with a customer, determining the performance obligations in the contract, determining the contract price, allocating the contract price to the distinct performance obligations in the contract, and recognizing revenue when the performance obligations have been satisfied. Revenue recognition for contracts with multiple deliverables is based on the separate satisfaction of each distinct performance obligation within the contract. A performance obligation is considered distinct from other obligations in a contract when it provides a benefit to the customer either on its own or together with other resources that are readily available to the customer and is separately identified in the contract. We consider a performance obligation satisfied once we have transferred control of a good or service to the customer, meaning the customer has the ability to use and obtain the benefit of the good or service. The contract price is allocated to each performance obligation in proportion to its standalone selling price. We determine our best estimate of standalone selling price using average selling prices over a rolling 12-month period coupled with an assessment of current market conditions. If the product or service has no history of sales or if the sales volume is not sufficient, we rely upon prices set by management, adjusted for applicable discounts.

Revenue from product sales is recognized generally upon delivery to the end customer, which is when control of the product is deemed to be transferred. Invoicing typically occurs upon shipment and payment is typically due within 60 days from invoice. In instances where right of payment or transfer of title is contingent upon the customer’s acceptance of the product, revenue is deferred until all acceptance criteria have been met. Revenue from genotyping and sequencing services, including cancer detection testing services related to the GRAIL business, is recognized when earned, which is generally at the time the genotyping or sequencing analysis data is made available to the customer. Revenue from instrument service contracts is recognized as the services are rendered, typically evenly over the contract term. Revenue from development and licensing agreements generally includes upfront and periodic licensing fees, contract research and development services, or payments for development and regulatory milestones. Revenue for these agreements is recognized when each distinct performance obligation is satisfied.

Revenue is recorded net of discounts, distributor commissions, and sales taxes collected on behalf of governmental authorities. Employee sales commissions are recorded as selling, general and administrative expense when incurred as the amortization period for such costs, if capitalized, would have been one year or less.

In certain markets, products and services are sold to customers through distributors. In most sales through distributors, the product is delivered directly to customers by us. The terms of sales transactions through distributors are consistent with the terms of direct sales to customers.

Earnings per Share

Basic earnings per share attributable to Illumina stockholders is computed based on the weighted average number of common shares outstanding during the period. Diluted earnings per share attributable to Illumina stockholders is computed based on the sum of the weighted average number of common shares and potentially dilutive common shares outstanding during the period. Up to April 25, 2019, the date of the Helix deconsolidation, per-share losses of Helix were included in the consolidated basic and diluted earnings per share computations based on our share of the entities’ securities.

Potentially dilutive common shares consist of shares issuable under convertible senior notes and equity awards. Convertible senior notes have a dilutive impact when the average market price of our common stock exceeds the applicable conversion price of the respective notes. Potentially dilutive common shares from equity awards are determined using the average share price for each period under the treasury stock method. In addition, proceeds from exercise of equity awards and the average amount of unrecognized compensation expense for equity awards are assumed to be used to repurchase shares.
The following table presents the calculation of weighted average shares used to calculate basic and diluted earnings per share:
 Years Ended
In millionsJanuary 2,
2022
January 3,
2021
December 29,
2019
Weighted average shares outstanding150 147 147 
Effect of potentially dilutive common shares from:
Equity awards1 
Convertible senior notes — 
Weighted average shares used in calculating diluted earnings per share
151 148 149 

Fair Value Measurements

The fair value of assets and liabilities are based on the exchange price that would be received for an asset or paid to transfer a liability (an exit price) in the principal or most advantageous market for the asset or liability in an orderly transaction between market participants on the measurement date. Valuation techniques used to measure fair value maximize the use of observable inputs and minimize the use of unobservable inputs. We use a fair value hierarchy with three levels of inputs, of which the first two are considered observable and the last unobservable, to measure fair value:

Level 1 — Quoted prices in active markets for identical assets or liabilities.
Level 2 — Inputs, other than Level 1, that are observable, either directly or indirectly, such as quoted prices for similar assets or liabilities; quoted prices in markets that are not active; or other inputs that are observable or can be corroborated by observable market data for substantially the full term of the assets or liabilities.
Level 3 — Unobservable inputs that are supported by little or no market activity and that are significant to the fair value of the assets or liabilities.

The carrying amounts of financial instruments such as cash and cash equivalents, accounts receivable, prepaid expenses and other current assets, accounts payable, and accrued liabilities approximate the related fair values due to the short-term maturities of these instruments.

Cash Equivalents and Debt Securities

Cash equivalents are comprised of short-term, highly-liquid investments with maturities of 90 days or less at the date of purchase.

We have historically held debt securities in U.S. government-sponsored entities, corporate debt securities, and U.S. Treasury securities. We have the ability, if necessary, to liquidate such short-term debt securities to meet our liquidity needs in the next 12 months. Accordingly, those investments with contractual maturities greater than one year from the date of purchase are classified as short-term investments on the accompanying consolidated balance sheets. We classify short-term debt investments as available-for-sale at the time of purchase and evaluate such classification as of each balance sheet date. All short-term debt investments are recorded at estimated fair value. We evaluate our available-for-sale debt securities in an unrealized loss position to assess whether such unrealized loss positions are credit-related. The credit-related portion of unrealized losses, and any subsequent improvements, are recorded in interest income through an allowance account. Unrealized gains and losses that are not credit-related are included in accumulated other comprehensive income, a component of stockholders’ equity. Realized gains and losses are determined based on the specific identification method and are recorded in interest income in the consolidated statements of income.
Equity Securities and Investments

We have strategic investments in privately-held companies (non-marketable equity securities) and companies that have completed initial public offerings (marketable equity securities). Our marketable equity securities are measured at fair value. Our non-marketable equity securities without readily determinable market values are initially measured at cost and adjusted to fair value for observable transactions for identical or similar investments of the same issuer or impairment. Equity investments are classified as current, short-term investments, or noncurrent, recorded in other assets, based on the nature of the securities and their availability for use in current operations. Unrealized gains and losses on our equity investments are recorded in other income, net in the consolidated statements of income.

Our equity investments are assessed for impairment quarterly. Impairment losses, equal to the difference between the carrying value and the fair value of the investment, are recorded in other income, net.

We use the equity method to account for investments through which we have the ability to exercise significant influence, but not control, over the investee. Such investments are recorded in other assets, and our share of net income or loss is recognized on a one quarter lag in other income, net.

Accounts Receivable

Trade accounts receivable are recorded at the net invoice value and are not interest-bearing. Receivables are considered past due based on the contractual payment terms. We reserve a percentage of our trade receivable balance based on collection history and current economic trends that we expect will impact the level of credit losses over the life of our receivables. These reserves are re-evaluated on a regular basis and adjusted, as needed. Once a receivable is deemed to be uncollectible, such balance is charged against the reserve.

Inventory

Inventory is stated at the lower of cost or net realizable value, on a first-in, first-out basis. Inventory includes raw materials and finished goods that may be used in the research and development process, and such items are expensed as consumed or capitalized as property and equipment and depreciated. Inventory write-downs for slow-moving, excess, and obsolete inventories are estimated based on product life cycles, quality issues, historical experience, and usage forecasts.

Property and Equipment

Property and equipment are stated at cost, subject to review for impairment, and depreciated over the estimated useful lives of the assets, using the straight-line method. Depreciation of leasehold improvements is recorded over the shorter of the lease term or the estimated useful life of the related assets. Maintenance and repairs are expensed as incurred. When assets are sold, or otherwise disposed of, the cost and related accumulated depreciation are removed from the accounts and any gain or loss is included in operating expense.

Costs incurred to develop internal-use software during the application development stage are recorded as computer software costs, at cost. Costs incurred in the development of such internal-use software, including external direct costs of materials and services and applicable compensation costs of employees devoted to specific software application development, are capitalized. Costs incurred outside of the application development stage are expensed as incurred.

The estimated useful lives of the major classes of property and equipment are generally as follows:
Estimated Useful Lives
Buildings and leasehold improvements
4 to 20 years
Machinery and equipment
3 to 5 years
Computer hardware and software
3 to 9 years
Furniture and fixtures
7 years
Leases

We lease approximately 3 million square feet of office, lab, manufacturing, and distribution facilities under various non-cancellable operating lease agreements (real estate leases). Our real estate leases have remaining lease terms of approximately 1 to 18 years, which represent the non-cancellable periods of the leases and include extension options that we determined are reasonably certain to be exercised. We exclude extension options that are not reasonably certain to be exercised from our lease terms, ranging from approximately 6 months to 20 years. Our lease payments consist primarily of fixed rental payments for the right to use the underlying leased assets over the lease terms, as well as payments for common-area-maintenance and administrative services. We often receive customary incentives from our landlords, such as reimbursements for tenant improvements and rent abatement periods, which effectively reduce the total lease payments owed for these leases. Leases are classified as operating or financing at commencement. We do not have any material financing leases.

Operating lease right-of-use assets and liabilities on our consolidated balance sheets represent the present value of our remaining lease payments over the remaining lease terms. We do not allocate lease payments to non-lease components; therefore, fixed payments for common-area-maintenance and administrative services are included in our operating lease right-of-use assets and liabilities. We use our incremental borrowing rate to calculate the present value of our lease payments, as the implicit rates in our leases are not readily determinable. Operating lease costs consist primarily of the fixed lease payments included in our operating lease liabilities and are recorded on a straight-line basis over the lease terms. We sublease certain real estate to third parties and this sublease income is also recorded on a straight-line basis.

Business Combinations

Under the acquisition method of accounting, we allocate the fair value of the total consideration transferred to the tangible and identifiable intangible assets acquired and liabilities assumed based on their estimated fair values on the date of acquisition. These valuations require us to make estimates and assumptions, especially with respect to intangible assets. We record the excess consideration over the aggregate fair value of tangible and intangible assets, net of liabilities assumed, as goodwill. Costs that we incur to complete the business combination, such as legal and other professional fees, are expensed as they are incurred.

In connection with certain acquisitions, contingent consideration can be earned by the sellers upon completion of certain future performance milestones. In these cases, a liability is recorded on the acquisition date, as a component of accrued liabilities and/or other long-term liabilities, for an estimate of the acquisition date fair value of the contingent consideration. These estimates require significant management judgment, including probabilities of achieving certain future milestones. Changes in the fair value of the contingent consideration subsequent to the acquisition date are recognized in selling, general and administrative expense in our consolidated statements of income.

If the initial accounting for a business combination is incomplete by the end of a reporting period that falls within the measurement period, we report provisional amounts in our financial statements. During the measurement period, we adjust the provisional amounts recognized at the acquisition date to reflect new information obtained about facts and circumstances that existed as of the acquisition date that, if known, would have affected the measurement of the amounts recognized as of that date. We record these adjustments to the provisional amounts with a corresponding offset to goodwill. Any adjustments identified after the measurement period are recorded in the consolidated statements of income.

Goodwill, Intangible Assets and Other Long-Lived Assets

Assets acquired, including intangible assets and capitalized in-process research and development (IPR&D), and liabilities assumed are measured at fair value as of the acquisition date. Goodwill, which has an indefinite useful life, represents the excess of cost over fair value of the net assets acquired. Intangible assets acquired in a business combination that are used for IPR&D activities are considered indefinite lived until the completion or abandonment of the associated research and development efforts. Upon reaching the end of the relevant research and development project (i.e., upon commercialization), the IPR&D asset is amortized over its estimated useful life. If the relevant research and development project is abandoned, the IPR&D asset is expensed in the period of abandonment.
Goodwill and IPR&D are not amortized; however, they are reviewed for impairment at least annually during the second quarter, or more frequently if an event occurs indicating the potential for impairment. Goodwill and IPR&D are considered to be impaired if the carrying value of the reporting unit or IPR&D asset exceeds its respective fair value.

We perform our goodwill impairment analysis at the reporting unit level, which aligns with our reporting structure and availability of discrete financial information. During the goodwill impairment review, we assess qualitative factors to determine whether it is more likely than not that the fair values of our reporting units are less than the carrying amounts, including goodwill. The qualitative factors include, but are not limited to, macroeconomic conditions, industry and market considerations, and our overall financial performance. If, after assessing the totality of these qualitative factors, we determine that it is not more likely than not that the fair values of our reporting units are less than the carrying amounts, then no additional assessment is deemed necessary. Otherwise, we proceed to compare the estimated fair values of the reporting units with the carrying values, including goodwill. If the carrying amounts of the reporting units exceed the fair values, we record an impairment loss based on the difference. We may elect to bypass the qualitative assessment in a period and proceed to perform the quantitative goodwill impairment test.

Our identifiable intangible assets with a finite life are typically comprised of acquired developed technologies, licensed technologies, customer relationships, license agreements, and trade names. The cost of identifiable intangible assets with finite lives is generally amortized on a straight-line basis over the assets’ respective estimated useful lives.

We perform regular reviews to determine if any event has occurred that may indicate that intangible assets with finite useful lives and other long-lived assets are potentially impaired. If indicators of impairment exist, an impairment test is performed to assess the recoverability of the affected assets by determining whether the carrying amount of such assets exceeds the undiscounted expected future cash flows. If the affected assets are not recoverable, we estimate the fair value of the assets and record an impairment loss if the carrying value of the assets exceeds the fair value. Factors that may indicate potential impairment include a significant decline in our stock price and market capitalization compared to the net book value, significant changes in the ability of a particular asset to generate positive cash flows for our strategic business objectives, and the pattern of utilization of a particular asset.

Derivative Financial Instruments

We are exposed to foreign exchange rate risks in the normal course of business and use derivative financial instruments to partially offset this exposure. We do not use derivative financial instruments for speculative or trading purposes. All foreign exchange contracts are carried at fair value in other current assets or accrued liabilities on the consolidated balance sheets.

We use foreign exchange forward contracts to manage foreign currency risks related to monetary assets and liabilities denominated in currencies other than the U.S. dollar. These derivative financial instruments have terms of one month or less and are not designated as hedging instruments. Changes in fair value of these derivatives are recognized in other income, net, along with the re-measurement gain or loss on the foreign currency denominated assets or liabilities. As of January 2, 2022, we had foreign exchange forward contracts in place to hedge exposures to monetary assets and liabilities denominated in the euro, Japanese yen, Australian dollar, Canadian dollar, Singapore dollar, Chinese Yuan Renminbi, and British pound. As of January 2, 2022 and January 3, 2021, the total notional amounts of outstanding forward contracts in place for these foreign currency purchases were $462 million and $405 million, respectively.

We also use foreign currency forward contracts to hedge portions of our foreign currency exposure associated with forecasted revenue transactions. These derivative financial instruments have terms up to 24 months and are designated as cash flow hedges. Changes in fair value of our cash flow hedges are recorded as a component of accumulated other comprehensive income and are reclassified to revenue in the same period the underlying hedged transactions are recorded. We regularly review the effectiveness of our cash flow hedges and consider them to be ineffective if it becomes probable that the forecasted transactions will not occur in the identified period. Changes in fair value of the ineffective portions of our cash flow hedges, if any, will be recognized in other income, net. As of January 2, 2022, we had foreign currency forward contracts in place to hedge exposures associated with forecasted revenue transactions denominated in the euro, Japanese yen, Australian dollar, and Canadian dollar. As of January 2, 2022 and January 3, 2021, the total notional amounts of outstanding cash flow hedge contracts in place for these foreign currency purchases were $450 million and $305 million, respectively. There were no outstanding cash flow hedge contracts in place as of December 29, 2019.
Warranties

We generally provide a one-year warranty on instruments. Additionally, we provide a warranty on consumables through the expiration date, which generally ranges from six to twelve months after the manufacture date. At the time revenue is recognized, an accrual is established for estimated warranty expenses based on historical experience as well as anticipated product performance. We periodically review the warranty reserve for adequacy and adjust the warranty accrual, if necessary, based on actual experience and estimated costs to be incurred. Warranty expense is recorded as a component of cost of product revenue.

Share-Based Compensation

Share-based compensation expense is incurred related to restricted stock, cash-based equity incentive awards, Employee Stock Purchase Plan (ESPP), and stock options.

Restricted stock units (RSU) and performance stock units (PSU) are both considered restricted stock. The fair value of restricted stock is determined by the closing market price of our common stock on the date of grant. Share-based compensation expense is recognized based on the fair value on a straight-line basis over the requisite service periods of the awards. PSU represents a right to receive a certain number of shares of common stock based on the achievement of corporate performance goals and continued employment during the vesting period. At each reporting period, we reassess the probability of the achievement of such corporate performance goals and any increase or decrease in share-based compensation expense resulting from an adjustment in the estimated shares to be released is treated as a cumulative catch-up in the period of adjustment.

Cash-based equity incentive awards are classified as liability awards, as such awards will be settled in cash. The cash to be awarded may increase or decrease in direct correlation to changes in the enterprise fair value of GRAIL, as defined under the Cash-Based Equity Appreciation Award Plan. The fair value of the awards is recorded over the respective vesting periods of the awards, with recognition of a corresponding liability recorded in accrued liabilities in the consolidated balance sheets. The awards are remeasured to fair value at each reporting date until the award is settled, with changes in fair value recognized in share-based compensation expense.

The Black-Scholes-Merton option-pricing model is used to estimate the fair value of stock purchased under our ESPP and stock options granted. The model assumptions include expected volatility, term, dividends, and the risk-free interest rate. The expected volatility is determined by equally weighing the historical and implied volatility of our common stock. The historical volatility is generally commensurate with the estimated expected term, adjusted for the impact of unusual fluctuations and other relevant factors. The implied volatility is calculated from the implied market volatility of exchange-traded call options on our common stock. The expected term is based on historical forfeiture experience, exercise activity, and on the terms and conditions of the stock awards. The expected dividend yield is determined to be 0% given that we have never declared or paid cash dividends on our common stock and do not anticipate paying such cash dividends. The risk-free interest rate is based upon U.S. Treasury securities with remaining terms similar to the expected term of the share-based awards.

Forfeitures are accounted for, as incurred, as a reversal of share-based compensation expense related to awards that will not vest.

Shipping and Handling Expenses

Shipping and handling expenses are included in cost of product revenue.

Research and Development

Research and development expenses include personnel expenses, contractor fees, facilities-related costs, material costs, and license fees. Expenditures relating to research and development are expensed in the period incurred.
Advertising Costs

Advertising costs are expensed as incurred. Advertising costs were $48 million in 2021 and $28 million in both 2020 and 2019.

Income Taxes

The provision for income taxes is computed using the asset and liability method, under which deferred tax assets and liabilities are recognized for the expected future tax consequences of temporary differences between the financial reporting and tax bases of assets and liabilities, and for the expected future tax benefit to be derived from tax loss and credit carryforwards. Deferred tax assets and liabilities are determined using the enacted tax rates in effect for the years in which those tax assets are expected to be realized. The effect of a change in tax rates on deferred tax assets and liabilities is recognized in the provision for income taxes in the period that includes the enactment date.

Deferred tax assets are regularly assessed to determine the likelihood they will be recovered from future taxable income. A valuation allowance is established when we believe it is more likely than not the future realization of all or some of a deferred tax asset will not be achieved. In evaluating the ability to recover deferred tax assets within the jurisdiction which they arise, we consider all available positive and negative evidence. Factors reviewed include the cumulative pre-tax book income for the past three years, scheduled reversals of deferred tax liabilities, history of earnings and reliable forecasting, projections of pre-tax book income over the foreseeable future, and the impact of any feasible and prudent tax planning strategies.
The impact of a tax position is recognized in the consolidated financial statements only if that position is more likely than not of being sustained upon examination by taxing authorities, based on the technical merits of the position. Any interest and penalties related to uncertain tax positions will be reflected in income tax expense.
v3.22.0.1
Revenue
12 Months Ended
Jan. 02, 2022
Revenue from Contract with Customer [Abstract]  
Revenue
2. REVENUE
Our revenue is generated primarily from the sale of products and services. Product revenue primarily consists of sales of instruments and consumables used in genetic analysis. Service and other revenue primarily consists of revenue generated from genotyping and sequencing services, instrument service contracts, development and licensing agreements, and cancer detection testing services related to the GRAIL business.
Revenue by Source

202120202019
in millionsSequencingMicroarrayTotalSequencingMicroarrayTotalSequencingMicroarrayTotal
Consumables$2,911 $306 $3,217 $2,039 $265 $2,304 $2,075 $317 $2,392 
Instruments734 17 751 417 14 431 517 20 537 
Total product revenue3,645 323 3,968 2,456 279 2,735 2,592 337 2,929 
Service and other revenue464 94 558 423 81 504 476 138 614 
Total revenue$4,109 $417 $4,526 $2,879 $360 $3,239 $3,068 $475 $3,543 

Revenue by Geographic Area

Based on region of destination (in millions)202120202019
Americas (1)
$2,358 $1,744 $1,970 
Europe, Middle East, and Africa1,289 886 933 
Greater China (2)
502 342 372 
Asia-Pacific377 267 268 
Total revenue$4,526 $3,239 $3,543 
_____________
(1)Revenue for the Americas region included United States revenue of $2,195 million, $1,655 million, and $1,859 million in 2021, 2020, and 2019, respectively.
(2)Region includes revenue from China, Taiwan, and Hong Kong.

Performance Obligations

We regularly enter into contracts with multiple performance obligations. Most performance obligations are generally satisfied within a short time frame, approximately three to six months, after the contract execution date. As of January 2, 2022, the aggregate amount of the transaction price allocated to remaining performance obligations was $1,035 million, of which approximately 89% is expected to be converted to revenue in 2022, approximately 9% in the following twelve months, and the remainder thereafter.

Contract Assets and Liabilities

Contract assets, which consist of revenue recognized and performance obligations satisfied or partially satisfied in advance of customer billing, as of January 2, 2022 and January 3, 2021 were $16 million and $15 million, respectively, of which the short-term portions of $16 million and $14 million, respectively, were recorded in prepaid expenses and other current assets, and the remaining long-term portions were recorded in other assets.
Contract liabilities, which consist of deferred revenue and customer deposits, as of January 2, 2022 and January 3, 2021 were $297 million and $230 million, respectively, of which the short-term portions of $234 million and $186 million, respectively, were recorded in accrued liabilities and the remaining long-term portions were recorded in other long-term liabilities. The increase is primarily related to an increase in instrument service contracts invoiced to customers for which the performance obligations have not yet been completed. Revenue recorded in 2021 included $183 million of previously deferred revenue that was included in contract liabilities as of January 3, 2021.
v3.22.0.1
Investments and Fair Value Measurements
12 Months Ended
Jan. 02, 2022
Fair Value Disclosures [Abstract]  
Investments and Fair Value Measurements
3. INVESTMENTS AND FAIR VALUE MEASUREMENTS
Debt Securities

In 2021, we sold all of our available-for-sale debt securities in order to fund the GRAIL acquisition. See note “4. Acquisitions, Goodwill and Intangible Assets” for further details regarding the acquisition. For 2020, our short-term investments included available-for-sale debt securities that consisted of the following:

 January 3, 2021
In millions
 Amortized
Cost
Gross
Unrealized
Gains
 
Estimated
Fair Value
Debt securities in government-sponsored entities
$10 $— $10 
Corporate debt securities445 — 445 
U.S. Treasury securities830 831 
Total
$1,285 $$1,286 

Strategic Investments

Marketable Equity Securities

As of January 2, 2022 and January 3, 2021, the fair value of our marketable equity securities, included in short-term investments, totaled $107 million and $376 million, respectively. The decrease was primarily due to sales of our marketable equity securities in 2021.

Gains and losses recognized in other income, net on our marketable equity securities for 2021, 2020, and 2019 were as follows:

In millions202120202019
Net (losses) gains recognized during the period on marketable equity securities$(52)$270 $53 
Less: Net losses recognized during the period on marketable equity securities sold during the period89 — — 
Net unrealized gains recognized during the period on marketable equity securities still held at the reporting date$37 $270 $53 

Non-Marketable Equity Securities

As of January 2, 2022 and January 3, 2021, the aggregate carrying amounts of our non-marketable equity securities without readily determinable fair values, included in other assets, were $40 million and $314 million, respectively. The decrease was due to our acquisition of GRAIL and the reclassification of several of our equity investments, that became marketable in 2021, to short-term investments.

On August 18, 2021, we completed our acquisition of GRAIL. Prior to the acquisition, we held an investment in GRAIL for which we had concluded that GRAIL was a VIE for which we were not the primary beneficiary and, therefore, we did not consolidate GRAIL in our consolidated financial statements. The carrying value of our investment was $250 million as of January 3, 2021. During 2020, we made an additional $60 million investment in GRAIL. See note “4. Acquisitions, Goodwill and Intangible Assets” for further details.

Revenue recognized from transactions with our strategic investees was $74 million, $62 million, and $71 million in 2021, 2020, and 2019, respectively.
Venture Funds

We invest in two venture capital investment funds (the Funds) with capital commitments of $100 million, callable through April 2026, and up to $150 million, callable through July 2029, respectively, of which $20 million and up to $118 million, respectively, remained callable as of January 2, 2022. Our investments in the Funds are accounted for as equity-method investments. The aggregate carrying amounts of the Funds, included in other assets, were $173 million and $104 million as of January 2, 2022 and January 3, 2021, respectively. We recorded net unrealized gains of $55 million, $20 million, and $9 million in 2021, 2020, and 2019, respectively, in other income, net.

Previously Consolidated Variable Interest Entity

In July 2015, we obtained a 50% voting equity ownership interest in Helix Holdings I, LLC (Helix). At that time, we determined that we had unilateral power over one of the activities that most significantly impacts the economic performance of Helix through its contractual arrangements and, as a result, we were deemed to be the primary beneficiary of Helix and were required to consolidate Helix. The operations of Helix are included in the accompanying consolidated statements of income for 2019, up to the date of the deconsolidation, described below. During this period, we absorbed 50% of Helix’s losses.

On April 25, 2019, we entered into an agreement to sell our interest in, and relinquish control over, Helix. As part of the agreement, (i) Helix repurchased all of our outstanding equity interests in exchange for a contingent value right with a 7-year term that entitles us to consideration dependent upon the outcome of Helix’s future financing and/or liquidity events, (ii) we ceased having a controlling financial interest in Helix, including unilateral power over one of the activities that most significantly impacts the economic performance of Helix, (iii) we were relieved of any potential obligation to redeem certain noncontrolling interests, and (iv) we no longer have representation on Helix’s board of directors. As a result, we deconsolidated Helix’s financial statements effective April 25, 2019 and recorded a gain on deconsolidation in 2019 of $39 million in other income, net. The gain on deconsolidation included (i) the contingent value right received from Helix recorded at a fair value of approximately $30 million, (ii) the derecognition of the carrying amounts of Helix’s assets and liabilities, and (iii) the derecognition of the noncontrolling interests related to Helix.

Changes in the fair value of our Helix contingent value right resulted in unrealized gains of $30 million and $7 million in 2021 and 2020, respectively, and an unrealized loss of $1 million in 2019, included in other income, net.

Derivative Assets Related to Terminated Acquisition

On November 1, 2018, we entered into an Agreement and Plan of Merger (the PacBio Merger Agreement) to acquire Pacific Biosciences of California, Inc. (PacBio) for an all-cash price of approximately $1.2 billion (or $8.00 per share). On January 2, 2020, we entered into an agreement to terminate the PacBio Merger Agreement (the Termination Agreement). Pursuant to the Termination Agreement, we made a cash payment to PacBio of $98 million on January 2, 2020, which represented the Reverse Termination Fee (as defined in the PacBio Merger Agreement). The Reverse Termination Fee was repayable, without interest, if PacBio entered into a definitive agreement providing for, or consummating, a Change of Control Transaction by September 30, 2020 (as defined in the Termination Agreement), and such transaction was consummated by the two-year anniversary of the execution of the definitive agreement for such Change of Control Transaction. PacBio did not enter into a definitive agreement that provided for, or consummated, a Change of Control Transaction by September 30, 2020 (as defined in the Termination Agreement); therefore, the Reverse Termination Fee is no longer repayable.

In addition, we made cash payments to PacBio of $18 million in Q4 2019, pursuant to Amendment No. 1 to the PacBio Merger Agreement, and $34 million in Q1 2020, pursuant to the Termination Agreement, collectively referred to as the Continuation Advances. Up to the $52 million of Continuation Advances was repayable, without interest, if, within two years of March 31, 2020, PacBio entered into a Change of Control Transaction or raised at least $100 million in equity or debt financing in a single transaction (with the amount repayable dependent on the amount raised by PacBio). In February 2021, PacBio entered into an investment agreement with SB Northstar LP for the issuance and sale of $900 million in aggregate principal amount of PacBio’s convertible notes. Pursuant to the PacBio Merger Agreement, PacBio repaid to us the $52 million of Continuation Advances and we recorded a gain of $26 million in 2021, which was included in other income, net.
The potential repayments of the Continuation Advances and Reverse Termination Fee met the definition of derivative assets and were recorded at fair value. The $92 million difference between the $132 million in cash paid during Q1 2020 for the Continuation Advances and Reverse Termination Fee and the $40 million fair value of these derivative assets on the payment dates was recorded as selling, general and administrative expense in 2020. The $8 million difference between the $18 million in Continuation Advances paid in Q4 2019 and the $10 million fair value of the derivative asset on the payment date was recorded as selling, general, and administrative expense in 2019. Changes in the fair value of the derivative assets were included in other income, net and totaled $25 million in unrealized losses in 2020.

Fair Value Measurements

The following table presents the hierarchy for assets and liabilities measured at fair value on a recurring basis:
January 2, 2022January 3, 2021
In millionsLevel 1Level 2Level 3TotalLevel 1Level 2Level 3Total
Assets:
Money market funds (cash equivalents)$688 $ $ $688 $1,512 $— $— $1,512 
Debt securities in government-sponsored entities    — 10 — 10 
Corporate debt securities    — 445 — 445 
U.S. Treasury securities    831 — — 831 
Marketable equity securities107   107 376 — — 376 
Helix contingent value right  65 65 — — 35 35 
Derivative assets related to terminated acquisition    — — 26 26 
Deferred compensation plan assets 60  60 — 55 — 55 
Total assets measured at fair value$795 $60 $65 $920 $2,719 $510 $61 $3,290 
Liabilities:
Contingent consideration liabilities$ $ $615 $615 $— $— $— $— 
Deferred compensation plan liability 56  56 — 51 — 51 
Total liabilities measured at fair value$ $56 $615 $671 $— $51 $— $51 

We consider information provided by our investment accounting and reporting service provider in the measurement of fair value of our debt securities. The investment service provider provides valuation information from an industry-recognized valuation service. Such valuations may be based on trade prices in active markets for identical assets or liabilities (Level 1 inputs) or valuation models using inputs that are observable either directly or indirectly (Level 2 inputs), such as quoted prices for similar assets or liabilities, yield curve, volatility factors, credit spreads, default rates, loss severity, current market and contractual prices for the underlying instruments or debt, broker and dealer quotes, as well as other relevant economic measures. Our marketable equity securities are measured at fair value based on quoted trade prices in active markets. Our deferred compensation plan assets consist primarily of investments in life insurance contracts carried at cash surrender value, which reflects the net asset value of the underlying publicly traded mutual funds. We perform control procedures to corroborate the fair value of our holdings, including comparing valuations obtained from our investment service provider to valuations reported by our asset custodians, validating pricing sources and models, and reviewing key model inputs, if necessary.

We elected the fair value option to measure the contingent value right received from Helix. The fair value of such contingent value right, included in other assets, is derived using a Monte Carlo simulation. Estimates and assumptions used in the Monte Carlo simulation include probabilities related to the timing and outcome of future
financing and/or liquidity events, assumptions regarding collectibility and volatility, and an estimated equity value of Helix. The derivative assets related to the terminated acquisition of PacBio were financial instruments measured at fair value, included in other assets. Estimates and assumptions required to value the derivative assets included, but were not limited to, probabilities related to the timing and outcome of future financing and/or liquidity events and an assumption regarding collectibility. The unobservable inputs used to value our Helix contingent value right and the derivative assets related to the terminated acquisition of PacBio represent Level 3 measurements because they are supported by little or no market activity and reflect our own assumptions in measuring fair value.

We reassess the fair value of contingent consideration to be settled in cash related to acquisitions on a quarterly basis. We use a Monte Carlo simulation to estimate the fair value of contingent consideration related to the GRAIL acquisition and an income approach to estimate the fair value of contingent consideration related to our other acquisition. See note “4. Acquisitions, Goodwill and Intangible Assets” for details regarding the contingent consideration arrangement related to the GRAIL acquisition. Estimates and assumptions used in the Monte Carlo simulation include forecasted revenues for GRAIL, a revenue risk premium, a revenue volatility, an operational leverage ratio and a counterparty credit spread. Estimates and assumptions used in the income approach include the probability of achieving certain milestones and a discount rate. These unobservable inputs represent a Level 3 measurement because they are supported by little or no market activity and reflect our own assumptions in measuring fair value. Changes in the fair value of contingent consideration subsequent to the acquisition date are recognized in selling, general and administrative expense in our consolidated statements of income.

Changes in the estimated fair value of contingent consideration liabilities during 2021 were as follows:
In millions
Balance as of January 3, 2021
$ 
Acquisition of GRAIL762 
Other acquisition14 
Measurement period adjustment(5)
Cash payments(15)
Exchange of GRAIL contingent value rights(145)
Change in estimated fair value4 
Balance as of January 2, 2022
$615 

We recorded a measurement period adjustment in Q4 2021 related to the acquisition of GRAIL to reduce the acquisition-date fair value of contingent consideration by $5 million as a result of revised future cash flow estimates. The measurement period adjustment would have resulted in an increase of $7 million to the gain previously recorded in Q3 2021 for the change in the estimated fair value of the contingent consideration liability. The measurement period adjustment has been recorded in our consolidated financial statements as of and for the year ended 2021 and was made to reflect facts and circumstances that existed as of the acquisition date.
We recorded a contingent consideration liability of $14 million as a result of an acquisition completed in Q2 2021. The acquisition-date fair value of the contingent consideration was derived using the income approach. Assumptions used to estimate the liability included the probability of achieving certain milestones and a discount rate. We recorded an expense of $1 million in selling, general and administrative expense in 2021 due to the change in estimated fair value of the contingent consideration and made a payment of $15 million in Q4 2021 upon achievement of the milestones.
v3.22.0.1
Acquisitions, Goodwill and Intangible Assets
12 Months Ended
Jan. 02, 2022
Business Combination And Goodwill And Intangible Assets [Abstract]  
Acquisitions, Goodwill and Intangible Assets
4. ACQUISITIONS, GOODWILL AND INTANGIBLE ASSETS
Acquisition of GRAIL, Inc.

On August 18, 2021, we completed our acquisition of GRAIL, a healthcare company focused on early detection of multiple cancers. The acquisition is expected to accelerate access and adoption of GRAIL’s blood test, Galleri, that detects various types of cancers before they are symptomatic. The acquisition is subject to ongoing legal proceedings and pending the European Commission’s ongoing merger review. Refer to note “8. Legal Proceedings” for further details. As a result of the acquisition, GRAIL stockholders received as consideration (i) cash, (ii) shares of Illumina common stock and (iii) at their election, either a contingent value right or additional shares of Illumina common stock. We issued 9.8 million common shares as part of the consideration.
GRAIL is a separate reportable segment. See note “11. Segment and Geographic Data” for more information. We have included the financial results of GRAIL in the consolidated financial statements from the date of acquisition.

During the fourth quarter of 2021, we recorded a measurement period adjustment related to the valuations of contingent consideration and our previously held investment in GRAIL that reduced the acquisition date fair value of each by $5 million and $1 million, respectively, and reduced the acquisition date fair value of goodwill by $6 million.

The total purchase price consisted of the following:

in millionsAs Adjusted
Cash$2,862 
Fair value of common stock issued4,975 
Fair value of contingent consideration757 
Fair value of previously held investment1,149 
Settlement of preexisting relationships2 
Total purchase price$9,745 

The contingent consideration relates to the GRAIL stockholders who elected to receive contingent value rights as part of the acquisition (the Contingent Value Rights Agreement). The contingent value rights entitle the holders to receive future cash payments representing a pro rata portion of certain GRAIL-related revenues each year for a 12-year period starting at the acquisition date. This will reflect a 2.5% payment right to the first $1 billion of revenue each year for 12 years. Revenue above $1 billion each year will be subject to a 9% contingent payment right during this same period. The acquisition-date fair value of the contingent consideration was measured using a Monte Carlo simulation. Estimates and assumptions used in the fair value assessment included forecasted revenues for GRAIL, a revenue risk premium, a revenue volatility, an operational leverage ratio and a counterparty credit spread. As of January 2, 2022, the estimated fair value of the contingent consideration liability was $615 million, of which $614 million was included in other long-term liabilities, with the remaining balance included in accrued liabilities. We recorded a net loss of $3 million in selling, general and administrative expense in 2021 due to changes in the estimated fair value of the contingent consideration liability. In December 2021, we exchanged approximately 73 million contingent value rights, that were issued as part of the acquisition, for an aggregate cash payment of $57 million and the issuance of $2 million in shares of our common stock. As a result of the exchange, we recognized a gain of $86 million in other income, net in 2021, which represents the difference between the fair value of the contingent consideration liability for the contingent value rights exchanged of $145 million and the total consideration transferred of $59 million.

Prior to the acquisition, we owned a 12% interest in GRAIL. Authoritative guidance on accounting for business combinations requires that an acquirer remeasure its previously held equity investment in the acquiree at its acquisition-date fair value and recognize the resulting gain or loss in earnings. We remeasured our previously held equity investment to its fair value, as of the date of acquisition, based on the fair value of total consideration transferred and a discount for lack of control. Estimates and assumptions used in the remeasurement represent a Level 3 measurement because they are supported by little or no market activity and reflect our own assumptions in measuring the fair value. As a result of the remeasurement, we valued our previously held equity investment in GRAIL at $1.1 billion and recognized a gain of $899 million, included in other income, net, in 2021.

In connection with the acquisition, we accelerated the vesting of certain outstanding and unvested equity awards of GRAIL employees. Approximately $69 million was included in the purchase price related to the fair value of accelerated equity awards attributable to the pre-combination period, with the fair value attributable to the post-combination period of $615 million included in share-based compensation expense in 2021. In addition, we issued Illumina equity awards to GRAIL employees in exchange for any of their remaining outstanding and unvested GRAIL equity awards (the “replacement awards”) at acquisition. The replacement awards consist of restricted stock units and performance stock options. The terms of the replacement awards are substantially similar to the former GRAIL equity awards for which they were exchanged. The fair value of the replacement awards was $48 million, all of which is attributable to post-combination service, and will be recognized as share-based compensation expense over the remaining vesting period subsequent to the acquisition. The weighted-average acquisition-date fair value of the replacement performance stock options was determined using the Black-Scholes option pricing model with the
following assumptions: (i) market price of $510.61 per share, which was the closing price of Illumina’s common stock on the acquisition date; (ii) weighted average expected term ranging from 1.6 years to 2.2 years; (iii) weighted-average risk-free interest rate ranging from 0.17% to 0.28%; (iv) weighted average annualized volatility ranging from 40% to 43%; and (v) no dividend yield. The weighted-average acquisition-date fair value per share of the replaced performance stock options was $424.39. Refer to note “6. Stockholders’ Equity” for more information.

The preliminary fair values of assets acquired and liabilities assumed were:
in millionsAs Initially ReportedMeasurement Period AdjustmentsAs Adjusted
Cash and cash equivalents$571 $— $571 
Property and equipment89 — 89 
Operating lease right-of-use assets121 — 121 
Goodwill6,082 15 6,097 
Intangible assets3,180 (60)3,120 
Other current and noncurrent assets35 — 35 
Deferred tax liability(82)40 (42)
Long-term lease liabilities(97)— (97)
Other current and noncurrent liabilities(148)(1)(149)
Total net assets acquired$9,751 $(6)$9,745 

We recorded measurement period adjustments in Q4 2021 to decrease intangible assets, specifically, developed technology, as a result of revised future cash flow estimates and to decrease deferred tax liability as a result of changes in net operating loss estimates from the initial purchase price allocation. These measurement period adjustments were made to reflect facts and circumstances that existed as of the acquisition date. The measurement period adjustment related to the developed technology intangible asset would have resulted in an insignificant decrease in amortization expense previously recorded in Q3 2021. The measurement period adjustments have been recorded in our consolidated financial statements as of and for the year ended 2021.

We are still finalizing the allocation of the purchase price, therefore, the fair value estimates assigned to intangible assets, goodwill and the related tax impacts of the acquisition, among other items, are subject to change as additional information is received to complete our analysis and certain tax returns are finalized. We expect to finalize the valuation as soon as practicable, but no later than one year after the acquisition date.

Goodwill is primarily attributable to assembled workforce, expanded market opportunities, and expected synergies to be achieved. The goodwill recognized was assigned to the GRAIL segment and is not deductible for tax purposes.

The preliminary fair values assigned to identifiable intangible assets acquired were as follows:

in millions, except yearsFair Value
(as adjusted)
Estimated Useful Life
Developed technology$2,410 18
Trade name40 9
In-process research and development (IPR&D)670 Indefinite
Total intangible assets$3,120 
The fair values of the developed technology, trade name and IPR&D were estimated using an income approach. Under the income approach, an intangible asset’s fair value is equal to the present value of future economic benefits to be derived from ownership of the asset. The estimated fair values were developed by discounting future net cash flows to their present value at market-based rates of return and inclusive of an assumption for technology obsolescence. The useful lives of the intangible assets for amortization purposes were determined by considering the period of expected cash flows used to measure the fair values of the intangible assets adjusted as appropriate for entity-specific factors including legal, regulatory, contractual, competitive, economic and other factors that may limit the useful life. The developed technology and trade name assets are amortized on a straight-line basis over their estimated useful lives. As of January 2, 2022, the research and development project had not been completed or abandoned and, therefore, the IPR&D intangible asset is not currently subject to amortization.

The transaction costs associated with the acquisition of GRAIL, excluding any Continuation Payments paid to GRAIL prior to the close of the acquisition, consisted primarily of legal, regulatory and financial advisory fees of approximately $156 million, which were expensed as incurred as selling, general and administrative expense in 2021.

Unaudited Pro Forma Financial Information

The following unaudited pro forma financial information summarizes the combined results of operations of Illumina and GRAIL as if the companies had been combined as of the beginning of our fiscal year 2020.

in millions20212020
Revenue$4,528 $3,239 
Net income$661 $351 

The unaudited pro forma financial information is presented for information purposes only and is not indicative of the results of operations that would have been achieved had the acquisition been completed at the beginning of our fiscal year 2020. In addition, the unaudited pro forma financial information is not a projection of future results of operations of the combined company nor does it reflect the expected realization of any synergies or cost savings associated with the acquisition. The unaudited pro forma financial information includes adjustments to reflect the elimination of intercompany transactions, incremental amortization and depreciation expense of the identifiable intangible assets and property and equipment acquired, respectively, the additional interest expense associated with the issuance of debt to finance the acquisition, and share-based compensation expense.

Prior to the acquisition, we were required to make monthly cash payments to GRAIL of $35 million (the Continuation Payments) through the earlier of the consummation of the acquisition or termination of the GRAIL Merger Agreement, subject to certain exceptions. We made Continuation Payments to GRAIL totaling $245 million and $35 million in 2021 and 2020, respectively, which were recorded as selling, general and administrative expense. Subsequent to the acquisition, we did not make any additional monthly payments.

Goodwill
In millionsGoodwill
Balance as of December 29, 2019$824 
Acquisitions73 
Balance as of January 3, 2021897 
Acquisitions6,201 
Measurement period adjustments15 
Balance as of January 2, 2022$7,113 

Goodwill is reviewed for impairment at least annually during the second quarter, or more frequently if an event occurs indicating the potential for impairment. We performed our annual assessment for goodwill impairment in the second quarter of 2021, noting no impairment.
Intangible Assets
 January 2, 2022January 3, 2021
In millionsGross
Carrying
Amount
Accumulated
Amortization
Intangible Assets,
Net
Gross
Carrying
Amount
Accumulated
Amortization
Intangible Assets,
Net
Developed technologies$2,790 $(291)$2,499 $352 $(221)$131 
Licensed technologies95 (92)3 95 (91)
Trade name44 (6)38 (4)— 
Customer relationships31 (28)3 31 (27)
License agreements14 (12)2 14 (11)
Total finite-lived intangible assets, net2,974 (429)2,545 496 (354)142 
In-process research and development (IPR&D)705  705 — — — 
Total intangible assets, net$3,679 $(429)$3,250 $496 $(354)$142 

As a result of an acquisition completed in Q2 2021, we recorded an IPR&D intangible asset of $35 million, with an indefinite useful life. As of January 2, 2022, the research and development project had not been completed or abandoned and, therefore, the IPR&D intangible asset is not currently subject to amortization. Additionally, as a result of another acquisition completed in Q3 2021, we recorded a developed technology intangible asset of $28 million, with a useful life of 10 years. As a result of an acquisition completed in 2020, we recorded a developed technology intangible asset of $26 million, with a useful life of 10 years.

The estimated future annual amortization of finite-lived intangible assets is shown in the following table. Actual amortization expense to be reported in future periods could differ from these estimates as a result of acquisitions, divestitures, and asset impairments, among other factors.

In millionsEstimated Annual Amortization
2022$165 
2023164 
2024162 
2025162 
2026151 
Thereafter1,741 
Total$2,545 
v3.22.0.1
Debt and Other Commitments
12 Months Ended
Jan. 02, 2022
Debt Disclosure [Abstract]  
Debt and Other Commitments
5. DEBT AND OTHER COMMITMENTS
Summary of Term Debt Obligations
In millionsJanuary 2,
2022
Principal amount of 2031 Term Notes outstanding$500 
Principal amount of 2023 Term Notes outstanding500 
Unamortized discounts and debt issuance costs(7)
Net carrying amount of term notes993 
Less: current portion 
Term notes, non-current$993 
Fair value of term notes outstanding (Level 2)$996 

0.550% Term Notes due 2023 (2023 Term Notes) and 2.550% Term Notes due 2031 (2031 Term Notes)

On March 23, 2021, we issued $500 million aggregate principal amount of term notes due 2023 (2023 Term Notes) and $500 million aggregate principal amount of term notes due 2031 (2031 Term Notes, together the Term Notes). We received net proceeds from the issuance of $992 million, after deducting discounts and debt issuance costs. The 2023 and 2031 Term Notes accrue interest at a rate of 0.550% and 2.550% per annum, respectively, payable semi-annually. Interest is payable on March 23 and September 23 of each year, beginning on September 23, 2021. The 2023 Term Notes mature on March 23, 2023 and the 2031 Term Notes mature on March 23, 2031.

We may redeem for cash all or any portion of the Term Notes, at our option, at any time prior to maturity. The 2023 Term Notes and, prior to December 23, 2030, the 2031 Term Notes are redeemable at make-whole premium redemption prices as defined in the applicable forms of note. After December 23, 2030, the 2031 Term Notes are redeemable at a redemption price equal to 100% of the principal amount of the notes to be redeemed, plus any accrued and unpaid interest up to, but excluding, the redemption date.

Interest expense recognized on the Term Notes was $14 million in 2021, which included amortization of debt discounts and issuance costs.

Summary of Convertible Debt Obligations
In millionsJanuary 2,
2022
January 3,
2021
Principal amount of 2023 Convertible Senior Notes outstanding$750 $750 
Principal amount of 2021 Convertible Senior Notes outstanding 517 
Unamortized discount of liability component of convertible senior notes(48)(83)
       Net carrying amount of liability component of convertible senior notes702 1,184 
Less: current portion (511)
Convertible senior notes, non-current$702 $673 
Carrying value of equity component of convertible senior notes, net of debt issuance costs
$126 $213 
Fair value of convertible senior notes outstanding (Level 2)$854 $1,595 
Weighted-average remaining amortization period of discount on the liability component of convertible senior notes1.6 years2.4 years

Interest expense recognized on the Convertible Senior Notes, which included amortization of debt discounts and issuance costs, was $36 million, $46 million, and $51 million in 2021, 2020, and 2019, respectively.

0% Convertible Senior Notes due 2023 (2023 Convertible Notes)

In August 2018, we issued $750 million aggregate principal amount of convertible senior notes due 2023 (2023 Convertible Notes). The net proceeds from the issuance, after deducting the offering expenses payable by us, were $735 million. The 2023 Convertible Notes carry no coupon interest and mature on August 15, 2023.
The 2023 Convertible Notes will be convertible into cash, shares of our common stock or a combination of cash and shares of our common stock, at our election, based on an initial conversion rate, subject to adjustment, of 2.1845 shares of common stock per $1,000 principal amount of notes (which represents an initial conversion price of approximately $457.77 per share of common stock), only in the following circumstances: (1) during any calendar quarter commencing after the calendar quarter ending on September 30, 2018 (and only during such calendar quarter), if the last reported sale price of our common stock for at least 20 trading days (whether or not consecutive) during a period of 30 consecutive trading days ending on, and including, the last trading day of the immediately preceding calendar quarter is greater than or equal to 130% of the conversion price in effect on each applicable trading day; (2) during the five business day period after any 10 consecutive trading day period (the “measurement period”) in which the trading price per $1,000 principal amount of 2023 Convertible Notes for each trading day of the measurement period was less than 98% of the product of the last reported sale price of our common stock and the conversion rate on each such trading day; (3) if we call any or all of the notes for redemption, at any time prior to the close of business on the scheduled trading day immediately preceding the redemption date; or (4) upon the occurrence of specified corporate events described in the indenture. Regardless of the foregoing circumstances, the holders may convert their notes on or after May 15, 2023 until August 11, 2023.

It is our intent and policy to settle conversions through combination settlement; this involves repayment of an amount of cash equal to the “principal amount” and delivery of the “share amount” in excess of the conversion value over the principal amount in shares of common stock. In general, for each $1,000 in principal, the “principal amount” of cash upon settlement is defined as the lesser of $1,000 and the conversion value during the 20-day observation period. The conversion value is the sum of the daily conversion value, which is the product of the effective conversion rate divided by 20 days and the daily volume weighted average price (VWAP) of our common stock. The “share amount” is the cumulative “daily share amount” during the observation period, which is calculated by dividing the daily VWAP into the difference between the daily conversion value (i.e., conversion rate x daily VWAP) and $1,000.

We may redeem for cash all or any portion of the 2023 Convertible Notes, at our option, on or after August 20, 2021 if the last reported sale price of our common stock has been at least 130% of the conversion price then in effect (currently $595.10) for at least 20 trading days (whether or not consecutive) during any 30 consecutive trading day period (including the last trading day of such period) ending on, and including, the trading day immediately preceding the date on which we provide notice of redemption at a redemption price equal to 100% of the principal amount of the notes to be redeemed, plus any accrued and unpaid special interest to, but excluding, the redemption date.
The 2023 Convertible Notes are accounted for in accordance with authoritative guidance for convertible debt instruments that may be settled in cash upon conversion. The guidance requires the carrying amount of the liability component to be estimated by estimating the fair value of a similar liability that does not have an associated conversion feature. Because at issuance we had no outstanding non-convertible public debt, we determined that market-traded senior, unsecured corporate bonds represent a similar liability without a conversion option. Based on market data available for publicly traded, senior, unsecured corporate bonds issued by companies in our industry, and with similar maturities to the 2023 Convertible Notes, we estimated an implied interest rate of 3.7%, assuming no conversion option. Assumptions used in the estimate represent what market participants would use in pricing the liability component, including market interest rates, credit standing, and yield curves, all of which are defined as Level 2 observable inputs. The estimated implied interest rate was applied to the 2023 Convertible Notes, which resulted in a fair value of the liability component in aggregate of $624 million upon issuance, calculated as the present value of implied future payments based on the $750 million aggregate principal amount. The $126 million difference ($93 million, net of tax) between the aggregate principal amount of $750 million and the estimated fair value of the liability component was recorded in additional paid-in capital as the 2023 Convertible Notes are not considered redeemable.

As a policy election under applicable guidance related to the calculation of diluted net income per share, we have elected the combination settlement method as our stated settlement policy and apply the treasury stock method in the calculation of the potential dilutive impact of the 2023 Convertible Notes on net income per share each period. The 2023 Convertible Notes were not convertible as of January 2, 2022 and had no dilutive impact in 2021, 2020, and 2019. If the notes were converted as of January 2, 2022, the if-converted value would not exceed the principal amount.
0.5% Convertible Senior Notes due 2021 (2021 Convertible Notes)

In June 2014, we issued $517 million aggregate principal amount of convertible senior notes due 2021 (2021 Convertible Notes). The implied estimated effective rate of the liability component of the notes was 3.5%, assuming no conversion option. The 2021 Convertible Notes were convertible into cash, shares of common stock, or a combination of cash and shares of common stock, at our election, based on conversion rates as defined in the indenture. The 2021 Convertible Notes matured on June 15, 2021, by which time the principal had been converted and was repaid in cash. The excess of the conversion value over the principal amount was paid in shares of common stock.

The following table summarizes information about the conversions during 2021:
In millions2021 Notes
Cash paid for principal of notes converted$517 
Conversion value over principal amount, paid in shares of common stock$313 
Number of shares of common stock issued upon conversion0.7 
Loss on extinguishment of debt$1 

Credit Agreement

On March 8, 2021, we entered into a credit agreement (the Credit Agreement), which provides us with a $750 million senior unsecured five-year revolving credit facility, including a $40 million sublimit for swingline borrowings and a $50 million sublimit for letters of credit (the Credit Facility). The proceeds of the loans under the Credit Facility may be used to finance working capital needs and for general corporate purposes.

Any loans under the Credit Facility will have a variable interest rate based on either the eurocurrency rate or the alternate base rate, plus an applicable spread that varies with the Company’s debt rating. The Credit Agreement includes an option for us to elect to increase the commitments under the Credit Facility or to enter into one or more tranches of term loans in the aggregate principal amount of up to $250 million, subject to the consent of the lenders providing the additional commitments or term loans, as applicable, and certain other conditions.

The Credit Agreement contains financial and operating covenants. Pursuant to the Credit Agreement, we are required to maintain a ratio of total debt to annual earnings before interest, taxes, depreciation and amortization (EBITDA), calculated based on the four consecutive fiscal quarters ending with the most recent fiscal quarter, of not greater than 3.50 to 1.00 as of the end of each fiscal quarter. Upon the consummation of any Qualified Acquisition (as defined in the Credit Agreement) and us providing notice to the Administrative Agent, the ratio increases to 4.00 to 1.00 for the fiscal quarter in which the acquisition is consummated and the three consecutive fiscal quarters thereafter. The operating covenants include, among other things, limitations on (i) the incurrence of indebtedness by our subsidiaries, (ii) liens on our and our subsidiaries assets, and (iii) certain fundamental changes and the disposition of assets by us and our subsidiaries. The Credit Agreement contains other customary covenants, representations and warranties, and events of default.

The Credit Facility matures, and all amounts outstanding thereunder become due and payable in full, on March 8, 2026, subject to two one-year extensions at our option, the consent of the extending lenders and certain other conditions. We may prepay amounts borrowed and terminate commitments under the Credit Facility at any time without premium or penalty.

As of January 2, 2022, there were no borrowings outstanding under the Credit Facility, and we were in compliance with all financial and operating covenants.

Bridge Facility

In advance of the acquisition of GRAIL, we obtained a bridge facility commitment letter from Goldman Sachs Bank USA for a 364-day senior unsecured bridge loan facility, in an aggregate principal amount of $1 billion. The bridge facility commitment letter was subject to certain conditions, including consummation of the acquisition pursuant to the
GRAIL Merger Agreement. On March 23, 2021, we terminated the bridge facility commitment letter in conjunction with the issuance of the 2023 and 2031 Term Notes.

Leases

As of January 2, 2022, the maturities of our operating lease liabilities were as follows:
In millions
2022$103
2023101
2024112
2025105
2026103
Thereafter517
Total remaining lease payments (1)
1,041
Less: imputed interest(196)
Total operating lease liabilities845
Less: current portion(71)
Long-term operating lease liabilities$774
Weighted-average remaining lease term9.9 years
Weighted-average discount rate4.1 %
_____________
(1)Total remaining lease payments exclude $8 million of legally binding minimum lease payments for leases signed but not yet commenced.

The components of our lease costs were as follows:
In millions202120202019
Operating lease costs$99 $84 $84 
Sublease income(16)(11)(12)
Total lease costs$83 $73 $72 

Purchase Obligations

In the normal course of business, we enter into agreements to purchase goods or services that are not cancelable without penalty, primarily related to licensing and supply arrangements. For those agreements with variable terms, we do not estimate the total obligation beyond any minimum quantities or pricing as of the reporting date. Licensing agreements under which we commit to minimum royalty payments, some of which are subject to adjustment, may be terminated prior to the expiration of underlying intellectual property under certain circumstances. Annual minimum payments for noncancelable purchase obligations as of January 2, 2022 were not material.
v3.22.0.1
Stockholders' Equity
12 Months Ended
Jan. 02, 2022
Equity [Abstract]  
Stockholders' Equity
6. STOCKHOLDERS’ EQUITY
The 2015 Stock and Incentive Compensation Plan (the 2015 Stock Plan) and the New Hire Stock and Incentive Plan allow for the issuance of stock options, performance stock options, restricted stock units and awards, and performance stock units. As of January 2, 2022, approximately 3.4 million shares remained available for future grants under the 2015 Stock Plan. There is no set number of shares reserved for issuance under the New Hire Stock and Incentive Plan.
Restricted Stock

We issue restricted stock units (RSU) and performance stock units (PSU), both of which are considered restricted stock. We grant restricted stock pursuant to the 2015 Stock Plan and satisfy such grants through the issuance of new shares. RSU are share awards that, upon vesting, will deliver to the holder shares of our common stock. RSU generally vest over a four-year period with equal vesting annually. We issue PSU for which the number of shares issuable at the end of a three-year performance period is based on our performance relative to specified earnings per share targets and continued employment through the vesting period.

Restricted stock activity was as follows:
Restricted
Stock Units
(RSU) (1)
Performance
Stock Units
(PSU)(2)
Weighted-Average Grant-
Date Fair Value per Share
Units in thousandsRSUPSU
Outstanding at December 30, 20181,840 660 $227.00 $196.99 
Awarded698 (41)$313.70 $254.52 
Vested(694)(283)$205.51 $133.11 
Cancelled(144)(65)$225.48 $181.79 
Outstanding at December 29, 20191,700 271 $271.49 $258.66 
Awarded878 (78)$329.83 $344.22 
Vested(655)(117)$239.19 $400.74 
Cancelled(202)(76)$273.13 $266.63 
Outstanding at January 3, 20211,721  $313.35 $ 
Awarded259 456 $438.46 $471.63 
Vested(606)(72)$303.08 $492.55 
Cancelled(244)(56)$321.93 $475.38 
Outstanding at January 2, 20221,130 328 $345.66 $466.42 
_____________
(1)In connection with the GRAIL acquisition, replacement awards of 59,000 RSU were awarded to GRAIL employees in 2021.
(2)The number of units reflect the estimated number of shares to be issued at the end of the performance period. Awarded units are presented net of performance adjustments.

Pre-tax intrinsic values and fair value of vested restricted stock was as follows:
In millions202120202019
Pre-tax intrinsic value of outstanding restricted stock:
RSU$430 $637 $565 
PSU$125 $— $90 
Fair value of restricted stock vested:
RSU$247 $206 $210 
PSU$35 $47 $38 
Stock Options

Stock option activity was as follows:
Units in thousandsOptionsWeighted-Average
Exercise Price
Performance Stock Options(1)
Weighted-Average
Exercise Price
Outstanding at December 30, 2018192 $54.52 — $— 
Exercised(134)$53.61 — $— 
Outstanding at December 29, 201958 $56.65 — $— 
Exercised(48)$56.16 — $— 
Outstanding at January 3, 202110 $59.11  $ 
Granted $ 48 $86.73 
Exercised(2)$20.06 (21)$86.72 
Cancelled $ (10)$89.63 
Outstanding at January 2, 20228 $66.42 17 $85.54 
_____________
(1)In connection with the GRAIL acquisition, we issued replacement performance stock options to GRAIL employees in 2021. The number of units reflect awards that have been granted and for which it is assumed to be probable that the underlying performance goals will be achieved.

As of January 2, 2022, all outstanding options were exercisable. The aggregate intrinsic value of options outstanding and options exercisable as of January 2, 2022 was $3 million. Aggregate intrinsic value represents the product of the number of options outstanding multiplied by the difference between our closing stock price per share on the last trading day of the fiscal period, which was $380.44 as of December 31, 2021, and the exercise price. Total intrinsic value of options exercised was $1 million, $14 million, and $34 million in 2021, 2020, and 2019, respectively. The weighted-average remaining life of options outstanding and exercisable was 1.4 years as of January 2, 2022.

There were no outstanding performance stock options exercisable as of January 2, 2022. The aggregate intrinsic value of performance stock options outstanding as of January 2, 2022 was $6 million and the total intrinsic value of performance stock options exercised was $6 million in 2021. Outstanding performance stock options, in general, have contractual terms of ten years from the respective grant dates.

Liability-Classified Awards

During 2021, we granted certain GRAIL employees cash-based equity incentive awards. The cash to be awarded may subsequently increase or decrease in direct correlation to changes in the enterprise fair value of GRAIL, as defined under the Cash-Based Equity Appreciation Award Plan. The awards generally have terms of four years and vest in four equal installments on each anniversary of the respective grant date, subject to continued employment through the vesting period. These awards are accounted for as liability-classified awards.

The aggregate grant date cash value for awards granted in 2021 was $218 million, of which, $42 million was forfeited in 2021. We recognized share-based compensation expense in 2021, with a corresponding liability as of January 2, 2022, included in accrued liabilities, of $11 million. As of January 2, 2022, approximately $173 million of total unrecognized compensation cost, which includes periodic estimated fair value adjustments, related to awards issued to date, was expected to be recognized over a weighted-average period of approximately 3.7 years.

Additionally, in connection with the acquisition of GRAIL, we assumed a performance-based award for which vesting is based on GRAIL’s future revenues. The award has an aggregate potential value of up to $78 million and expires, to the extent unvested, in August 2030. As of January 2, 2022, it was not probable that the performance conditions associated with the award will be achieved and, therefore, no share-based compensation expense, or corresponding liability, has been recognized in the consolidated financial statements to-date. We assess the probability of achieving the performance conditions associated with the award on a quarterly basis at each reporting period.
Employee Stock Purchase Plan

A total of 15.5 million shares of our common stock have been reserved for issuance under our 2000 Employee Stock Purchase Plan, or ESPP. The ESPP permits eligible employees to purchase common stock at a discount through payroll deductions during defined offering periods. The price at which stock is purchased under the ESPP is equal to 85% of the fair market value of the common stock on the first day of the offering period or purchase date, whichever is lower. The initial offering period commenced in July 2000.

Approximately 0.2 million shares were issued under the ESPP during each of the years in 2021, 2020, and 2019. As of January 2, 2022 and January 3, 2021, there were approximately 13.1 million and 13.3 million shares available for issuance under the ESPP, respectively.

Share Repurchases

We did not repurchase any shares during 2021. During 2020 and 2019, we repurchased approximately 2.3 million shares for $735 million and 1.1 million shares for $324 million, respectively. As of January 2, 2022, authorizations to repurchase approximately $15 million of our common stock remained available under the $750 million share repurchase program authorized by our Board of Directors on February 5, 2020. The repurchases may be completed under a 10b5-1 plan or at management’s discretion.

Share-Based Compensation
    
Share-based compensation expense, which includes expense for both equity and liability-classified awards, reported in our consolidated statements of income was as follows:
In millions202120202019
Cost of product revenue$23 $21 $19 
Cost of service and other revenue4 
Research and development276 74 66 
Selling, general and administrative638 95 105 
Share-based compensation expense, before taxes941 194 194 
Related income tax benefits(64)(43)(41)
Share-based compensation expense, net of taxes$877 $151 $153 

In connection with the acquisition of GRAIL, we recognized share-based compensation expense of $615 million in 2021 related to the fair value of accelerated equity awards attributable to the post-combination period, of which $167 million was recorded in research and development expense and $448 million in selling, general and administrative expense. We also recognized $24 million of expense in 2021 related to the replacement awards.

In February 2021, we modified the metrics and reduced the maximum potential payouts for our performance stock units granted in 2019 and 2020, which vest at the end of the three-year periods ended January 2, 2022 and January 1, 2023, respectively. The modifications affected 52 employees with units granted in 2019, which resulted in total incremental share-based compensation cost of approximately $41 million, and 72 employees with units granted in 2020, which resulted in total incremental share-based compensation cost of approximately $65 million.

Additionally, in August 2020, we modified the performance period for our performance stock units granted in 2018, which vested at the end of the three-year period ended January 3, 2021. This modification affected 49 employees and resulted in total incremental share-based compensation cost of approximately $47 million in 2020.
The assumptions used for the specified reporting periods and the resulting estimates of weighted-average fair value per share for stock purchased under the ESPP were as follows:
202120202019
Risk-free interest rate
0.06% - 0.12%
 0.11% - 2.04%
1.88% - 2.56%
Expected volatility
37% - 47%
 30% - 45%
30% - 38%
Expected term
0.5 - 1.0 year
 0.5 - 1.0 year
0.5 - 1.0 year
Expected dividends
0%
0%0%
Weighted-average grant-date fair value per share$134.47 $75.57 $75.47 

As of January 2, 2022, approximately $442 million of total unrecognized compensation cost related to restricted stock, performance stock options and ESPP shares issued to date was expected to be recognized over a weighted-average period of approximately 2.1 years.
v3.22.0.1
Supplemental Balance Sheet and Statement of Income Details
12 Months Ended
Jan. 02, 2022
Organization, Consolidation and Presentation of Financial Statements [Abstract]  
Supplemental Balance Sheet and Statement of Income Details
7. SUPPLEMENTAL BALANCE SHEET AND STATEMENT OF INCOME DETAILS
Accounts Receivable
in millionsJanuary 2,
2022
January 3,
2021
Trade accounts receivable, gross$651 $491 
Allowance for credit losses(3)(4)
Total accounts receivable, net$648 $487 

Inventory
in millionsJanuary 2,
2022
January 3,
2021
Raw materials$92 $106 
Work in process312 244 
Finished goods27 22 
Total inventory$431 $372 

Property and Equipment
in millionsJanuary 2,
2022
January 3,
2021
Leasehold improvements$724 $645 
Machinery and equipment513 461 
Computer hardware and software377 305 
Furniture and fixtures49 46 
Buildings44 44 
Construction in progress113 99 
Total property and equipment, gross1,820 1,600 
Accumulated depreciation(796)(678)
Total property and equipment, net$1,024 $922 

Property and equipment, net included non-cash expenditures of $17 million, $22 million and $20 million in 2021, 2020, and 2019, respectively, which were excluded from the consolidated statements of cash flows.
Accrued Liabilities
in millionsJanuary 2,
2022
January 3,
2021
Accrued compensation expenses$252 $153 
Contract liabilities, current portion234 186 
Accrued taxes payable98 68 
Operating lease liabilities, current portion71 51 
Contingent consideration liabilities, current portion1 — 
Other, including warranties (a)105 83 
Total accrued liabilities$761 $541 

(a) Changes in the reserve for product warranties were as follows:
in millions
Balance as of December 30, 2018$19 
Additions charged to cost of product revenue20 
Repairs and replacements(25)
Balance as of December 29, 201914 
Additions charged to cost of product revenue20 
Repairs and replacements(21)
Balance as of January 3, 202113 
Additions charged to cost of product revenue33 
Repairs and replacements(24)
Balance as of January 2, 2022$22 

Other Income, Net

in millions202120202019
Gain on previously held investment in GRAIL$899 $— $— 
Gain on exchange of GRAIL contingent value rights86 — — 
Gain (loss) on Helix contingent value right30 (1)
Gain (loss) on derivative assets related to terminated acquisition26 (25)— 
Gains on strategic investments, net18 291 62 
Gains on deconsolidations — 54 
Other9 11 (5)
Other income, net$1,068 $284 $110 
v3.22.0.1
Legal Proceedings
12 Months Ended
Jan. 02, 2022
Commitments and Contingencies Disclosure [Abstract]  
Legal Proceedings
8. LEGAL PROCEEDINGS
We are involved in various lawsuits and claims arising in the ordinary course of business, including actions with respect to intellectual property, employment, and contractual matters. In connection with these matters, we assess, on a regular basis, the probability and range of possible loss based on the developments in these matters. A liability is recorded in the consolidated financial statements if it is believed to be probable that a loss has been incurred and the amount of the loss can be reasonably estimated. Because litigation is inherently unpredictable and unfavorable resolutions could occur, assessing contingencies is highly subjective and requires judgments about future events. We regularly review outstanding legal matters to determine the adequacy of the liabilities accrued and related disclosures in consideration of many factors, which include, but are not limited to, past history, scientific and other evidence, and the specifics and status of each matter. We may change our estimates if our assessment of the various factors changes and the amount of ultimate loss may differ from our estimates, resulting in a material effect on our business, financial condition, results of operations, and/or cash flows.
Acquisition of GRAIL

On March 30, 2021, the Federal Trade Commission (the FTC) filed an administrative complaint and a motion for a preliminary injunction in the United States District Court for the District of Columbia. In both actions, the FTC alleged that our acquisition of GRAIL would violate Section 7 of the Clayton Act, as amended, 15 U.S.C. § 18. We filed an answer to the FTC’s complaint in federal district court on April 6, 2021, and in the administrative court on April 13, 2021. On April 20, 2021, the United States District Court for the District of Columbia granted our motion to transfer venue to the United States District Court for the Southern District of California. On May 28, 2021, the district court granted the FTC’s motion to dismiss the complaint without prejudice. The administrative trial commenced on August 24, 2021, and live testimony concluded on September 24, 2021. Post-trial briefing deadlines have not yet been scheduled. We intend to vigorously defend the FTC action.

On April 19, 2021, the European Commission accepted a request for a referral of the GRAIL acquisition for European Union merger review, submitted by a Member State of the European Union (France), and joined by several other Member States (Belgium, Greece, Iceland, the Netherlands and Norway), under Article 22(1) of Council Regulation (EC) No 139/2004 (the EU Merger Regulation). On April 29, 2021, we filed an action in the General Court of the European Union (the EU General Court) asking for annulment of the European Commission’s assertion of jurisdiction to review the acquisition under Article 22 of the EU Merger Regulation, as the acquisition does not meet the jurisdictional criteria under the EU Merger Regulation or under the national merger control laws of any Member State of the European Union. On December 16, 2021, the EU General Court held a hearing regarding the European Commission’s assertion of jurisdiction, and we await the court’s judgment. We intend to vigorously challenge the European Commission’s assertion of jurisdiction.

BGI Genomics Co. Ltd. and its Affiliates

We are involved in lawsuits against BGI Genomics Co. Ltd (BGI) and its affiliates, including Complete Genomics, Inc. (CGI), in the United States and elsewhere.

On June 27, 2019, we filed suit against BGI in the United States District Court for the Northern District of California, alleging that certain BGI sequencing products infringe our U.S. Patent No. 7,566,537 (‘537 patent) and U.S. Patent No. 9,410,200 (‘200 patent). BGI has denied our claims and has counterclaimed that our technology infringes U.S. Patent No. 9,944,984 (‘984 patent). We deny their allegations. On February 27, 2020, we filed a second patent infringement suit against BGI in the United States District Court for the Northern District of California alleging that BGI sequencing products infringed U.S. Patent 7,771,973 (‘973 patent), U.S. Patent 7,541,444 (‘444 patent), and U.S. Patent 10,480,025 (‘025 patent). On June 15, 2020, the Court granted our motions requesting preliminary injunctions against BGI, finding that our patents were likely valid and infringed by BGI’s chemistries. The injunction prohibits the sale of BGI’s sequencers and sequencing reagents in the US. On December 9, 2020, BGI filed a motion to amend its answer to our second suit to include allegations that the ‘444 and ‘937 patents are unenforceable under the doctrine of unequitable conduct; we deny BGI’s allegations. As of April 12, 2021, BGI is seeking approximately $54 million in alleged damages and an ongoing royalty of 3.6% on sales of the accused products by us in the United States until the ‘984 patent expires on June 13, 2026. We deny that we owe any damages or ongoing royalty. On August 27, 2021, and September 9, 2021, the Court issued its decisions on the summary judgment motions: (i) the Court granted our motion for summary judgment that we do not infringe BGI’s ‘984 patent; (ii) the Court granted our motion for summary judgment that our ‘444 and ‘973 patents are not unenforceable; (iii) the Court granted our motion for summary judgment that BGI’s standard MPS products infringe all of our patents-in-suit: (iv) the Court granted our motion for summary judgment that BGI’s “Cool MPS” sequencing products infringe the ‘973 and ‘444 patents, and granted BGI’s motion for summary judgment that BGI’s “Cool MPS” sequencing products do not infringe the ‘025 patent; and (v) the Court denied BGI’s motion for summary judgment that our ‘973 patent is invalid for lack of written description and enablement. Trial began on November 12, 2021, and the jury rendered a verdict on November 30, 2021. The jury found that the ‘537, ‘200, ‘973 patents and claims 9, 27, 31, 33, 34, 42, 47 of the ‘025 patent are valid and were willfully infringed by BGI. The jury also ruled that the claim 4 of the ‘444 patent and Claim 1 of the ‘025 patent were invalid as obvious. The jury awarded the Company $8 million in damages. A hearing on post-trial briefing is scheduled for March 2, 2022.

On January 11, 2021, Complete Genomics, Inc., BGI Americas Corp., and MGI Americas, Inc. also filed a complaint in the United States District Court for the Northern District of California alleging the Company and its subsidiary Illumina Cambridge Ltd. violated federal antitrust and state unfair competition laws. CGI and these affiliates allege that the Company fraudulently withheld a prior art reference that was material to patentability for the ‘444 and ‘973 patents.
They also allege that our infringement claims of the ‘025 against BGI’s “CoolMPS” chemistry were objectively baseless. The Company denies the allegations in the complaint. On March 30, 2021, the Court stayed the antitrust case pending resolution of the underlying patent infringement suit taking place in the same court.

On May 28, 2019, CGI filed suit against us in the United States District Court for the District of Delaware alleging that our two-channel sequencing systems, including the NovaSeq, NextSeq, and MiniSeq systems, infringe certain claims of U.S. Patent No. 9,222,132. We have denied CGI’s allegations and have counterclaimed for infringement by CGI, BGI Americas Corp., and MGI Americas, Inc. of U.S. Patent No. 9,303,290, U.S. Patent No. 9,217,178, and U.S. Patent No. 9,970,055. On August 15, 2019, CGI filed a motion to dismiss our counterclaims. On August 29, 2019, we filed our Opposition to the Motion to Dismiss. The Court denied and granted the motion in part, denying the motion as to our claims for inducing infringement and granting it for contributory infringement. The Court gave us leave to file an amended complaint to attempt to cure the alleged deficiencies as to contributory infringement. On July 1, 2020, CGI amended its complaint to add claims of infringement of U.S. Patent No. 10,662,473 by our two-channel sequencing systems. We deny these allegations. As of May 12, 2021, CGI is seeking $225 million in alleged past damages and an average ongoing royalty of 5.5% on sales of the accused two-channel sequencing instruments and chemistry in the U.S. until the patents-in-suit expire on January 28, 2029. We deny that we owe any damages or ongoing royalty. On October 22, 2021, pursuant to the Court’s local rules, the Company sought leave to file a motion for summary judgment of non-infringement of the CGI patents-in-suit. CGI sought leave to file a motion for summary judgment against the Company’s invalidity defense based on prior invention. On January 14, 2022, the Court denied the Company and CGI’s motions for leave to file for summary judgment. Trial is scheduled to begin April 18, 2022.
We will continue to pursue our claims against BGI and CGI, and vigorously defend against BGI’s and CGI’s claims. We currently cannot estimate any possible loss or range of loss that may result from BGI’s and CGI’s claims against us.
v3.22.0.1
Income Taxes
12 Months Ended
Jan. 02, 2022
Income Tax Disclosure [Abstract]  
Income Taxes
9. INCOME TAXES
Income (loss) before income taxes summarized by region was as follows:
In millions202120202019
United States$(115)$313 $242 
Foreign999 543 876 
Total income before income taxes$884 $856 $1,118 

The provision for income taxes consisted of the following:
In millions202120202019
Current:   
Federal$54 $25 $32 
State37 13 
Foreign107 45 84 
Total current provision$198 $83 $123 
Deferred:
Federal$(50)$30 $
State(23)94 (1)
Foreign(3)(7)
Total deferred (benefit) expense(76)117 
Total tax provision$122 $200 $128 
The provision for income taxes reconciles to the amount computed by applying the federal statutory rate to income before taxes as follows:
In millions202120202019
Tax at federal statutory rate$186 $180 $235 
State, net of federal benefit13 19 18 
Research and other credits(23)(19)(37)
Change in valuation allowance33 69 (2)
Impact of foreign operations(80)(47)(57)
Impact of foreign derived intangible income (FDII) deduction(12)(11)(4)
Cost sharing adjustment 28 — 
Investments in consolidated variable interest entities (2)(5)
Stock compensation(10)(18)(20)
Officer compensation13 
Impact of acquisition related items(16)— — 
Other18 (6)(5)
Total tax provision$122 $200 $128 

We have elected to account for the global intangible low-taxed income (GILTI) as a period cost in our consolidated financial statements.

The impact of foreign operations primarily represents the difference between the actual provision for income taxes for our legal entities that operate primarily in jurisdictions that have statutory tax rates lower than the U.S. federal statutory tax rate of 21%. The most significant tax benefits from foreign operations were from our earnings in Singapore and the United Kingdom, which had statutory tax rates of 17% and 19%, respectively, in 2021. The impact of foreign operations also includes the impact of GILTI and the U.S. foreign tax credit impact of non-U.S. earnings and uncertain tax positions related to foreign items.

The impact of acquisition related items includes the tax impact of the gain on our previously held investment in GRAIL, acquisition related compensation, continuation payments, transaction costs, and changes to the contingent value rights associated with the GRAIL acquisition.

On June 22, 2020, the Supreme Court denied petition for certiorari for Altera Corporation v. Commissioner. This effectively means the Ninth Circuit decision that stock-based compensation must be included in intercompany cost sharing is final. As a result, tax expense of $28 million was recorded in 2020.
Significant components of deferred tax assets and liabilities were as follows:
In millionsJanuary 2,
2022
January 3,
2021
Deferred tax assets:  
Net operating losses$513 $26 
Tax credits128 70 
Other accruals and reserves39 21 
Stock compensation23 17 
Other amortization225 17 
Operating lease liabilities173 156 
Other36 53 
Total gross deferred tax assets1,137 360 
Valuation allowance on deferred tax assets(134)(81)
Total deferred tax assets
$1,003 $279 
Deferred tax liabilities:  
Purchased intangible amortization$(828)$(27)
Convertible debt(11)(20)
Property and equipment(21)(34)
Operating lease right-of-use assets(129)(108)
Investments(29)(137)
Other(12)(6)
Total deferred tax liabilities(1,030)(332)
Deferred tax liabilities, net$(27)$(53)
A valuation allowance is established when it is more likely than not the future realization of all or some of the deferred tax assets will not be achieved. The evaluation of the need for a valuation allowance is performed on a jurisdiction-by-jurisdiction basis and includes a review of all available positive and negative evidence, including operating results and forecasted ranges of future taxable income. Based on the available evidence as of January 2, 2022, we were not able to conclude it is more likely than not certain deferred tax assets will be realized. Therefore, a valuation allowance of $134 million was recorded against certain U.S. and foreign deferred tax assets, of which $20 million was recorded as an adjustment to goodwill as a result of acquisitions that occurred in 2021.

As of January 2, 2022, we had net operating loss carryforwards for federal and state tax purposes of $1,873 million and $1,290 million, respectively, which will begin to expire in 2022 and 2029, respectively, unless utilized prior. We also had federal and state tax credit carryforwards of $50 million and $165 million, which will begin to expire in 2036 and 2027, respectively, unless utilized prior.

Pursuant to Section 382 and 383 of the Internal Revenue Code, utilization of net operating losses and credits may be subject to annual limitations in the event of any significant future changes in its ownership structure. These annual limitations may result in the expiration of net operating losses and credits prior to utilization. The deferred tax assets as of January 2, 2022 are net of any previous limitations due to Section 382 and 383.

Our manufacturing operations in Singapore operate under various tax holidays and incentives that begin to expire in 2023. These tax holidays and incentives resulted in an $82 million, $30 million, and $33 million decrease to the provision for income taxes in 2021, 2020, and 2019, respectively. These tax holidays and incentives resulted in an increase in diluted earnings per share attributable to Illumina stockholders of $0.55, $0.20, and $0.22, in 2021, 2020, and 2019, respectively.

As of January 2, 2022, we asserted that $1,067 million of foreign earnings would not be indefinitely reinvested, and accordingly, recorded a deferred tax liability of $11.5 million.
The following table summarizes the gross amount of our uncertain tax positions:
In millionsJanuary 2,
2022
January 3,
2021
December 29,
2019
Balance at beginning of year$80 $79 $88 
Increases related to prior year tax positions19 
Decreases related to prior year tax positions(1)— — 
Increases related to current year tax positions39 12 12 
Decreases related to lapse of statute of limitations(6)(13)(22)
Balance at end of year$131 $80 $79 
Included in the balance of uncertain tax positions as of January 2, 2022 and January 3, 2021, was $111 million and $68 million, respectively, of net unrecognized tax benefits that, if recognized, would reduce the effective income tax rate in future periods.

Any interest and penalties related to uncertain tax positions are reflected in the provision for income taxes. We recognized expense of $1 million in 2021, and income of $1 million and $3 million in 2020 and 2019, respectively, related to potential interest and penalties on uncertain tax positions. We recorded a liability for potential interest and penalties of $7 million and $6 million as of January 2, 2022 and January 3, 2021, respectively.

Tax years 1997 to 2020 remain subject to future examination by the major tax jurisdictions in which we are subject to tax. The Internal Revenue Service continues to examine the U.S. Corporation Income Tax Returns for tax years 2017 and 2018. Given the uncertainty of potential adjustments from examination as well as the potential expiration of the statute of limitations, it is reasonably possible that the balance of unrecognized tax benefits could change significantly over the next 12 months. Due to the number of years remaining that are subject to examination, we are unable to estimate the full range of possible adjustments to the balance of gross unrecognized tax benefits.
v3.22.0.1
Employee Benefit Plans
12 Months Ended
Jan. 02, 2022
Postemployment Benefits [Abstract]  
Employee Benefit Plans
10. EMPLOYEE BENEFIT PLANS
Retirement Plan

We have a 401(k) savings plan covering substantially all of our employees in the United States. Our contributions to the plan are discretionary. During 2021, 2020, and 2019, we made matching contributions of $26 million, $22 million, and $20 million, respectively.

Deferred Compensation Plan

The Illumina, Inc. Deferred Compensation Plan (the Plan) allows senior level employees to contribute up to 60% of their base salary and 100% of their variable cash compensation, and members of the board of directors to contribute up to 100% of their director fees and equity awards. Under the Plan, we credit the participants’ contributions with earnings that reflect the performance of certain independent investment funds. On a discretionary basis, we may also make employer contributions to participant accounts in any amount determined by us. The vesting schedules of employer contributions are at the sole discretion of the Compensation Committee. However, all employer contributions shall become 100% vested upon the occurrence of the participant’s disability, death or retirement or a change in control of Illumina. The benefits under this plan are unsecured. Participants are generally eligible to receive payment of their vested benefit at the end of their elected deferral period or after termination of their employment for any reason or at a later date to comply with the restrictions of Section 409A.
We also established a rabbi trust for the benefit of the participants under the Plan and have included the assets of the rabbi trust in the consolidated balance sheets. As of January 2, 2022 and January 3, 2021, the assets of the trust were $60 million and $55 million, respectively, and our liabilities were $56 million and $51 million, respectively. The assets and liabilities are classified as other assets and accrued liabilities, respectively, on the consolidated balance sheets. Changes in the values of the assets held by the rabbi trust are recorded in other income, net in the consolidated statements of income, and changes in the values of the deferred compensation liabilities are recorded in cost of revenue or operating expenses.
v3.22.0.1
Segments and Geographic Data
12 Months Ended
Jan. 02, 2022
Segment Reporting [Abstract]  
Segments and Geographic Data
11. SEGMENTS AND GEOGRAPHIC DATA
Reportable Segment Information

We have two reportable segments, Core Illumina and GRAIL. We do not allocate expenses between segments.

On August 18, 2021, we acquired GRAIL and it operates as a separate reportable segment. We have included the results of operations of GRAIL in our consolidated statements of operations from the date of acquisition. See note “4. Acquisitions, Goodwill and Intangible Assets” for further details. Core Illumina sells products and provides services to GRAIL, and vice versa, in accordance with contractual agreements between the entities.

Prior to the Helix deconsolidation on April 25, 2019, our reportable segments included Core Illumina and Helix. See note “3. Investments and Fair Value Measurements” for further details. Core Illumina sold products and provided services to Helix in accordance with contractual agreements between the entities.

Core Illumina:

Core Illumina’s products and services serve customers in the research, clinical and applied markets, and enable the adoption of a variety of genomic solutions. Core Illumina includes all of our operations, excluding the results of GRAIL in 2021 and the results of our previously consolidated VIE, Helix, in 2019.

GRAIL:

GRAIL is a healthcare company focused on early detection of multiple cancers.

Helix:

Helix was established to enable individuals to explore their genetic information by providing affordable sequencing and database services for consumers through third-party partners, driving the creation of an ecosystem of consumer applications.
 In millions202120202019
Revenue:
Core Illumina$4,519 $3,239 $3,543 
GRAIL12 — — 
Helix — 
Eliminations(5)— (1)
Consolidated revenue$4,526 $3,239 $3,543 
Depreciation and amortization:
Core Illumina$200 $187 $186 
GRAIL51 — — 
Helix — 
Eliminations  — (1)
Consolidated depreciation and amortization$251 $187 $188 
Income (loss) from operations:
Core Illumina$808 $580 $1,008 
GRAIL(931)— — 
Helix — (24)
Eliminations — 
Consolidated (loss) income from operations$(123)$580 $985 

Total other income, net primarily relates to Core Illumina and we do not allocate income taxes to our segments.

In millionsJanuary 2,
2022
January 3,
2021
December 29,
2019
Total assets:
Core Illumina$5,571 $7,585 $7,316 
GRAIL9,649 — — 
Helix — — 
Eliminations(3)— — 
Consolidated total assets$15,217 $7,585 $7,316 
Capital expenditures:
Core Illumina$201 $189 $209 
GRAIL8 — — 
Eliminations(1)— — 
Consolidated capital expenditures$208 $189 $209 
Geographic Data

Net long-lived assets, consisting of property and equipment and operating lease right-of-use assets, by region, were as follows:
In millionsJanuary 2,
2022
January 3,
2021
United States$1,281 $1,134 
Singapore218 150 
United Kingdom146 141 
Other countries51 29 
Total net long-lived assets$1,696 $1,454 
Refer to note “2. Revenue” for revenue by geographic area.
v3.22.0.1
Organization and Significant Accounting Policies (Policies)
12 Months Ended
Jan. 02, 2022
Accounting Policies [Abstract]  
Basis of Presentation The consolidated financial statements have been prepared in conformity with U.S. generally accepted accounting principles and include our accounts, our wholly-owned subsidiaries, majority-owned or controlled companies, and variable interest entities for which we are the primary beneficiary. All intercompany transactions and balances have been eliminated in consolidation. Certain prior period amounts have been reclassified to conform to the current period presentation. We have included the results of operations for GRAIL in our consolidated statements of operations from the date of acquisition. GRAIL operates as a separate reportable segment. See note “11. Segments and Geographic Data” for additional information.
Variable Interest Entities (VIEs) We evaluate our ownership, contractual and other interests in entities that are not wholly-owned to determine if these entities are VIEs, and, if so, whether we are the primary beneficiary of the VIE. In determining whether we are the primary beneficiary of a VIE and therefore required to consolidate the VIE, we apply a qualitative approach that determines whether we have both (1) the power to direct the activities of the VIE that most significantly impact the VIE’s economic performance and (2) the obligation to absorb losses of, or the rights to receive benefits from, the VIE that could potentially be significant to that VIE. We continuously perform this assessment, as changes to existing relationships or future transactions may result in the consolidation or deconsolidation of a VIE. See note “3. Investments and Fair Value Measurements” for further details.
Use of Estimates The preparation of the consolidated financial statements requires that management make estimates and assumptions that affect the reported amounts of assets, liabilities, revenues, expenses, and related disclosures of contingent assets and liabilities. Though the impact of the COVID-19 pandemic to our business and operating results presents additional uncertainty, we continue to use the best information available to inform our critical accounting estimates. Actual results could differ from those estimates.
Fiscal Year Our fiscal year is the 52 or 53 weeks ending the Sunday closest to December 31, with quarters of 13 or 14 weeks ending the Sunday closest to March 31, June 30, September 30, and December 31. References to 2021, 2020, and 2019 refer to fiscal years ended January 2, 2022, January 3, 2021, and December 29, 2019, respectively. Fiscal years 2021 and 2019 were both 52 weeks, and fiscal year 2020 was 53 weeks.
Functional Currency The U.S. dollar is the functional currency of our international operations. We re-measure foreign subsidiaries’ monetary assets and liabilities to the U.S. dollar and record the net gains or losses resulting from re-measurement in other income, net in the consolidated statements of income.
Concentrations of Risk
Customers

We operate in markets that are highly competitive and rapidly changing. Significant technological changes, shifting customer needs, the emergence of competitive products or services with new capabilities, and other factors could negatively impact our operating results. A portion of our customers consist of university and research institutions that management believes are, to some degree, directly or indirectly supported by the United States Government. A significant change in current research funding, particularly with respect to the U.S. National Institutes of Health, could have an adverse impact on future revenues and results of operations.

International sales entail a variety of risks, including currency exchange fluctuations, longer payment cycles, and greater difficulty in accounts receivable collection. We are also subject to general geopolitical risks, such as political, social and economic instability, and changes in diplomatic and trade relations. The risks of international sales are mitigated in part by the extent to which sales are geographically distributed. Shipments to customers outside the United States comprised 52%, 49%, and 48% of total revenue in 2021, 2020, and 2019, respectively. Customers outside the United States represented 57% and 56% of our gross trade accounts receivable balance as of January 2, 2022 and January 3, 2021, respectively.

We had no customers that provided more than 10% of total revenue in 2021, 2020, and 2019. We perform regular reviews of customer activity and associated credit risks and do not require collateral or enter into netting arrangements. Historically, we have not experienced significant credit losses from accounts receivable.

Financial Instruments

We are also subject to risks related to our financial instruments, including cash and cash equivalents, investments, and accounts receivable. Most of our cash and cash equivalents as of January 2, 2022 were deposited with U.S. financial institutions, either domestically or with their foreign branches. Our investment policy restricts the amount of credit exposure to any one issuer to 5% of the portfolio or 5% of the total issue size outstanding at the time of purchase and to any one industry sector, as defined by Clearwater Analytics (Industry Sector Report), to 30% of the portfolio at the time of purchase. There is no limit to the percentage of the portfolio that may be maintained in debt securities, U.S. government-sponsored entities, U.S. Treasury securities, and money market funds. Historically, we have not experienced significant credit losses from financial instruments.

Suppliers

We require customized products and components that currently are available from a limited number of sources. We source certain key products and components included in our products from single vendors.
Segments We report segment information based on the management approach. This approach designates the internal reporting used by the Chief Operating Decision Maker (CODM) for making decisions and assessing performance as the source of our reportable segments. The CODM allocates resources and assesses the performance of each operating segment using information about its revenue and income (loss) from operations. Management evaluates the performance of our reportable segments based upon income (loss) from operations. We do not allocate expenses between segments.
Accounting Pronouncements Adopted and Pending Adoption
Accounting Pronouncements Adopted in 2020

In May 2020, the SEC issued Final Rule Release No. 33-10786, Amendments to Financial Disclosures about Acquired and Disposed Businesses, which amends the disclosure requirements applicable to acquisitions and dispositions of businesses, including the required pro forma financial information. Among other changes, the final amendments revised the investment and income tests used to determine whether a business acquisition is significant and reduced the filing requirements for financial statements and pro forma financial information of a significant acquired business to cover a maximum of two years. We adopted the amendments in 2020 in connection with our acquisition of GRAIL, which is further described in note “4. Acquisitions, Goodwill and Intangible Assets.”

In June 2016, the FASB issued ASU 2016-13, Financial Instruments - Credit Losses: Measurement of Credit Losses on Financial Instruments, which amends the impairment model by requiring entities to use a forward-looking approach based on expected losses to estimate credit losses on certain types of financial instruments, including trade receivables and available-for-sale debt securities. We adopted the standard on its effective date in the first quarter of 2020 using a modified retrospective approach. The cumulative effect of applying the new credit loss standard was not material and, therefore, did not result in an adjustment to retained earnings. There was no material difference to the consolidated financial statements in 2020 due to the adoption of ASU 2016-13.

In accordance with ASU 2016-13, we no longer evaluate whether our available-for-sale debt securities in an unrealized loss position are other than temporarily impaired. Instead, we assess whether such unrealized loss positions are credit-related. The credit-related portion of unrealized losses, and any subsequent improvements, are recorded in interest income through an allowance account. Unrealized gains and losses that are not credit-related are included in accumulated other comprehensive income. We estimate our allowance for credit losses on our trade receivables as described in our Accounts Receivable policy, below.

Accounting Pronouncements Adopted in 2019

In February 2016, the FASB issued ASU 2016-02, Leases (Topic 842), which requires lessees to recognize most leases on the balance sheet as lease liabilities with corresponding right-of-use assets and to disclose key information about leasing arrangements. We adopted Topic 842 on its effective date in the first quarter of 2019 using a modified retrospective approach by recognizing a cumulative-effect adjustment to retained earnings as of December 31, 2018. We elected the available package of practical expedients upon adoption, which allowed us to carry forward our historical assessment of whether existing agreements contained a lease and the classification of our existing operating leases. The impact from adoption primarily resulted in the recognition of operating lease liabilities with corresponding right-of-use assets based on the present value of our remaining minimum lease payments, and the derecognition of existing fixed assets and financing obligations related to build-to-suit leasing arrangements that, under Topic 840, did not qualify for sale-leaseback accounting. We recorded a cumulative-effect adjustment to decrease retained earnings by $18 million, net of deferred tax, upon adoption on December 31, 2018.

Accounting Pronouncements Pending Adoption

In August 2020, the FASB issued ASU 2020-06, Debt - Debt with Conversion and Other Options (Subtopic 470-20) and Derivatives and Hedging - Contracts in Entity’s Own Equity (Subtopic 815-40). The new standard reduces the number of accounting models for convertible debt instruments, amends the accounting for certain contracts in an entity’s own equity, and modifies how certain convertible instruments and contracts that may be settled in cash or shares impact the calculation of diluted EPS. Specifically, the guidance removes certain accounting models that separate the embedded conversion features from the host contract for convertible instruments. The standard is effective for us beginning in the first quarter of 2022 and will be adopted using a modified retrospective approach by recognizing a cumulative-effect adjustment to the opening balance of retained earnings on January 3, 2022. We will continue to report financial information for fiscal years ending before January 3, 2022 under the current accounting guidance. As a result of the adoption, we expect to increase our convertible debt liabilities and retained earnings, on January 3, 2022, by approximately $43 million and $61 million, respectively, and decrease our deferred tax liabilities, included in other long-term liabilities on the consolidated balance sheets, and additional paid-in capital by approximately $11 million and $93 million, respectively.
Revenue Recognition, Shipping and Handling Expenses
Our revenue is generated primarily from the sale of products and services. Product revenue primarily consists of sales of instruments and consumables used in genetic analysis. Service and other revenue primarily consists of revenue generated from genotyping and sequencing services, instrument service contracts, development and licensing agreements, and cancer detection testing services related to the GRAIL business.

We recognize revenue when control of our products and services is transferred to our customers in an amount that reflects the consideration we expect to receive from our customers in exchange for those products and services. This process involves identifying the contract with a customer, determining the performance obligations in the contract, determining the contract price, allocating the contract price to the distinct performance obligations in the contract, and recognizing revenue when the performance obligations have been satisfied. Revenue recognition for contracts with multiple deliverables is based on the separate satisfaction of each distinct performance obligation within the contract. A performance obligation is considered distinct from other obligations in a contract when it provides a benefit to the customer either on its own or together with other resources that are readily available to the customer and is separately identified in the contract. We consider a performance obligation satisfied once we have transferred control of a good or service to the customer, meaning the customer has the ability to use and obtain the benefit of the good or service. The contract price is allocated to each performance obligation in proportion to its standalone selling price. We determine our best estimate of standalone selling price using average selling prices over a rolling 12-month period coupled with an assessment of current market conditions. If the product or service has no history of sales or if the sales volume is not sufficient, we rely upon prices set by management, adjusted for applicable discounts.

Revenue from product sales is recognized generally upon delivery to the end customer, which is when control of the product is deemed to be transferred. Invoicing typically occurs upon shipment and payment is typically due within 60 days from invoice. In instances where right of payment or transfer of title is contingent upon the customer’s acceptance of the product, revenue is deferred until all acceptance criteria have been met. Revenue from genotyping and sequencing services, including cancer detection testing services related to the GRAIL business, is recognized when earned, which is generally at the time the genotyping or sequencing analysis data is made available to the customer. Revenue from instrument service contracts is recognized as the services are rendered, typically evenly over the contract term. Revenue from development and licensing agreements generally includes upfront and periodic licensing fees, contract research and development services, or payments for development and regulatory milestones. Revenue for these agreements is recognized when each distinct performance obligation is satisfied.

Revenue is recorded net of discounts, distributor commissions, and sales taxes collected on behalf of governmental authorities. Employee sales commissions are recorded as selling, general and administrative expense when incurred as the amortization period for such costs, if capitalized, would have been one year or less.

In certain markets, products and services are sold to customers through distributors. In most sales through distributors, the product is delivered directly to customers by us. The terms of sales transactions through distributors are consistent with the terms of direct sales to customers.
Shipping and handling expenses are included in cost of product revenue.
Earnings per Share
Basic earnings per share attributable to Illumina stockholders is computed based on the weighted average number of common shares outstanding during the period. Diluted earnings per share attributable to Illumina stockholders is computed based on the sum of the weighted average number of common shares and potentially dilutive common shares outstanding during the period. Up to April 25, 2019, the date of the Helix deconsolidation, per-share losses of Helix were included in the consolidated basic and diluted earnings per share computations based on our share of the entities’ securities.

Potentially dilutive common shares consist of shares issuable under convertible senior notes and equity awards. Convertible senior notes have a dilutive impact when the average market price of our common stock exceeds the applicable conversion price of the respective notes. Potentially dilutive common shares from equity awards are determined using the average share price for each period under the treasury stock method. In addition, proceeds from exercise of equity awards and the average amount of unrecognized compensation expense for equity awards are assumed to be used to repurchase shares.
Fair Value Measurements
The fair value of assets and liabilities are based on the exchange price that would be received for an asset or paid to transfer a liability (an exit price) in the principal or most advantageous market for the asset or liability in an orderly transaction between market participants on the measurement date. Valuation techniques used to measure fair value maximize the use of observable inputs and minimize the use of unobservable inputs. We use a fair value hierarchy with three levels of inputs, of which the first two are considered observable and the last unobservable, to measure fair value:

Level 1 — Quoted prices in active markets for identical assets or liabilities.
Level 2 — Inputs, other than Level 1, that are observable, either directly or indirectly, such as quoted prices for similar assets or liabilities; quoted prices in markets that are not active; or other inputs that are observable or can be corroborated by observable market data for substantially the full term of the assets or liabilities.
Level 3 — Unobservable inputs that are supported by little or no market activity and that are significant to the fair value of the assets or liabilities.
The carrying amounts of financial instruments such as cash and cash equivalents, accounts receivable, prepaid expenses and other current assets, accounts payable, and accrued liabilities approximate the related fair values due to the short-term maturities of these instruments.
Cash Equivalents Cash equivalents are comprised of short-term, highly-liquid investments with maturities of 90 days or less at the date of purchase.
Debt Securities We classify short-term debt investments as available-for-sale at the time of purchase and evaluate such classification as of each balance sheet date. All short-term debt investments are recorded at estimated fair value. We evaluate our available-for-sale debt securities in an unrealized loss position to assess whether such unrealized loss positions are credit-related. The credit-related portion of unrealized losses, and any subsequent improvements, are recorded in interest income through an allowance account. Unrealized gains and losses that are not credit-related are included in accumulated other comprehensive income, a component of stockholders’ equity. Realized gains and losses are determined based on the specific identification method and are recorded in interest income in the consolidated statements of income.
Equity Securities and Investments
We have strategic investments in privately-held companies (non-marketable equity securities) and companies that have completed initial public offerings (marketable equity securities). Our marketable equity securities are measured at fair value. Our non-marketable equity securities without readily determinable market values are initially measured at cost and adjusted to fair value for observable transactions for identical or similar investments of the same issuer or impairment. Equity investments are classified as current, short-term investments, or noncurrent, recorded in other assets, based on the nature of the securities and their availability for use in current operations. Unrealized gains and losses on our equity investments are recorded in other income, net in the consolidated statements of income.

Our equity investments are assessed for impairment quarterly. Impairment losses, equal to the difference between the carrying value and the fair value of the investment, are recorded in other income, net.

We use the equity method to account for investments through which we have the ability to exercise significant influence, but not control, over the investee. Such investments are recorded in other assets, and our share of net income or loss is recognized on a one quarter lag in other income, net.
Accounts Receivable Trade accounts receivable are recorded at the net invoice value and are not interest-bearing. Receivables are considered past due based on the contractual payment terms. We reserve a percentage of our trade receivable balance based on collection history and current economic trends that we expect will impact the level of credit losses over the life of our receivables. These reserves are re-evaluated on a regular basis and adjusted, as needed. Once a receivable is deemed to be uncollectible, such balance is charged against the reserve.
Inventory Inventory is stated at the lower of cost or net realizable value, on a first-in, first-out basis. Inventory includes raw materials and finished goods that may be used in the research and development process, and such items are expensed as consumed or capitalized as property and equipment and depreciated. Inventory write-downs for slow-moving, excess, and obsolete inventories are estimated based on product life cycles, quality issues, historical experience, and usage forecasts.
Property and Equipment
Property and equipment are stated at cost, subject to review for impairment, and depreciated over the estimated useful lives of the assets, using the straight-line method. Depreciation of leasehold improvements is recorded over the shorter of the lease term or the estimated useful life of the related assets. Maintenance and repairs are expensed as incurred. When assets are sold, or otherwise disposed of, the cost and related accumulated depreciation are removed from the accounts and any gain or loss is included in operating expense.

Costs incurred to develop internal-use software during the application development stage are recorded as computer software costs, at cost. Costs incurred in the development of such internal-use software, including external direct costs of materials and services and applicable compensation costs of employees devoted to specific software application development, are capitalized. Costs incurred outside of the application development stage are expensed as incurred.
Leases
We lease approximately 3 million square feet of office, lab, manufacturing, and distribution facilities under various non-cancellable operating lease agreements (real estate leases). Our real estate leases have remaining lease terms of approximately 1 to 18 years, which represent the non-cancellable periods of the leases and include extension options that we determined are reasonably certain to be exercised. We exclude extension options that are not reasonably certain to be exercised from our lease terms, ranging from approximately 6 months to 20 years. Our lease payments consist primarily of fixed rental payments for the right to use the underlying leased assets over the lease terms, as well as payments for common-area-maintenance and administrative services. We often receive customary incentives from our landlords, such as reimbursements for tenant improvements and rent abatement periods, which effectively reduce the total lease payments owed for these leases. Leases are classified as operating or financing at commencement. We do not have any material financing leases.

Operating lease right-of-use assets and liabilities on our consolidated balance sheets represent the present value of our remaining lease payments over the remaining lease terms. We do not allocate lease payments to non-lease components; therefore, fixed payments for common-area-maintenance and administrative services are included in our operating lease right-of-use assets and liabilities. We use our incremental borrowing rate to calculate the present value of our lease payments, as the implicit rates in our leases are not readily determinable. Operating lease costs consist primarily of the fixed lease payments included in our operating lease liabilities and are recorded on a straight-line basis over the lease terms. We sublease certain real estate to third parties and this sublease income is also recorded on a straight-line basis.
Business Combinations
Under the acquisition method of accounting, we allocate the fair value of the total consideration transferred to the tangible and identifiable intangible assets acquired and liabilities assumed based on their estimated fair values on the date of acquisition. These valuations require us to make estimates and assumptions, especially with respect to intangible assets. We record the excess consideration over the aggregate fair value of tangible and intangible assets, net of liabilities assumed, as goodwill. Costs that we incur to complete the business combination, such as legal and other professional fees, are expensed as they are incurred.

In connection with certain acquisitions, contingent consideration can be earned by the sellers upon completion of certain future performance milestones. In these cases, a liability is recorded on the acquisition date, as a component of accrued liabilities and/or other long-term liabilities, for an estimate of the acquisition date fair value of the contingent consideration. These estimates require significant management judgment, including probabilities of achieving certain future milestones. Changes in the fair value of the contingent consideration subsequent to the acquisition date are recognized in selling, general and administrative expense in our consolidated statements of income.

If the initial accounting for a business combination is incomplete by the end of a reporting period that falls within the measurement period, we report provisional amounts in our financial statements. During the measurement period, we adjust the provisional amounts recognized at the acquisition date to reflect new information obtained about facts and circumstances that existed as of the acquisition date that, if known, would have affected the measurement of the amounts recognized as of that date. We record these adjustments to the provisional amounts with a corresponding offset to goodwill. Any adjustments identified after the measurement period are recorded in the consolidated statements of income.
Goodwill, Intangible Assets and Other Long-Lived Assets Assets acquired, including intangible assets and capitalized in-process research and development (IPR&D), and liabilities assumed are measured at fair value as of the acquisition date. Goodwill, which has an indefinite useful life, represents the excess of cost over fair value of the net assets acquired. Intangible assets acquired in a business combination that are used for IPR&D activities are considered indefinite lived until the completion or abandonment of the associated research and development efforts. Upon reaching the end of the relevant research and development project (i.e., upon commercialization), the IPR&D asset is amortized over its estimated useful life. If the relevant research and development project is abandoned, the IPR&D asset is expensed in the period of abandonment.
Goodwill and IPR&D are not amortized; however, they are reviewed for impairment at least annually during the second quarter, or more frequently if an event occurs indicating the potential for impairment. Goodwill and IPR&D are considered to be impaired if the carrying value of the reporting unit or IPR&D asset exceeds its respective fair value.

We perform our goodwill impairment analysis at the reporting unit level, which aligns with our reporting structure and availability of discrete financial information. During the goodwill impairment review, we assess qualitative factors to determine whether it is more likely than not that the fair values of our reporting units are less than the carrying amounts, including goodwill. The qualitative factors include, but are not limited to, macroeconomic conditions, industry and market considerations, and our overall financial performance. If, after assessing the totality of these qualitative factors, we determine that it is not more likely than not that the fair values of our reporting units are less than the carrying amounts, then no additional assessment is deemed necessary. Otherwise, we proceed to compare the estimated fair values of the reporting units with the carrying values, including goodwill. If the carrying amounts of the reporting units exceed the fair values, we record an impairment loss based on the difference. We may elect to bypass the qualitative assessment in a period and proceed to perform the quantitative goodwill impairment test.

Our identifiable intangible assets with a finite life are typically comprised of acquired developed technologies, licensed technologies, customer relationships, license agreements, and trade names. The cost of identifiable intangible assets with finite lives is generally amortized on a straight-line basis over the assets’ respective estimated useful lives.
We perform regular reviews to determine if any event has occurred that may indicate that intangible assets with finite useful lives and other long-lived assets are potentially impaired. If indicators of impairment exist, an impairment test is performed to assess the recoverability of the affected assets by determining whether the carrying amount of such assets exceeds the undiscounted expected future cash flows. If the affected assets are not recoverable, we estimate the fair value of the assets and record an impairment loss if the carrying value of the assets exceeds the fair value. Factors that may indicate potential impairment include a significant decline in our stock price and market capitalization compared to the net book value, significant changes in the ability of a particular asset to generate positive cash flows for our strategic business objectives, and the pattern of utilization of a particular asset.
Derivative Financial Instruments
We are exposed to foreign exchange rate risks in the normal course of business and use derivative financial instruments to partially offset this exposure. We do not use derivative financial instruments for speculative or trading purposes. All foreign exchange contracts are carried at fair value in other current assets or accrued liabilities on the consolidated balance sheets.

We use foreign exchange forward contracts to manage foreign currency risks related to monetary assets and liabilities denominated in currencies other than the U.S. dollar. These derivative financial instruments have terms of one month or less and are not designated as hedging instruments. Changes in fair value of these derivatives are recognized in other income, net, along with the re-measurement gain or loss on the foreign currency denominated assets or liabilities. As of January 2, 2022, we had foreign exchange forward contracts in place to hedge exposures to monetary assets and liabilities denominated in the euro, Japanese yen, Australian dollar, Canadian dollar, Singapore dollar, Chinese Yuan Renminbi, and British pound. As of January 2, 2022 and January 3, 2021, the total notional amounts of outstanding forward contracts in place for these foreign currency purchases were $462 million and $405 million, respectively.
We also use foreign currency forward contracts to hedge portions of our foreign currency exposure associated with forecasted revenue transactions. These derivative financial instruments have terms up to 24 months and are designated as cash flow hedges. Changes in fair value of our cash flow hedges are recorded as a component of accumulated other comprehensive income and are reclassified to revenue in the same period the underlying hedged transactions are recorded. We regularly review the effectiveness of our cash flow hedges and consider them to be ineffective if it becomes probable that the forecasted transactions will not occur in the identified period. Changes in fair value of the ineffective portions of our cash flow hedges, if any, will be recognized in other income, net. As of January 2, 2022, we had foreign currency forward contracts in place to hedge exposures associated with forecasted revenue transactions denominated in the euro, Japanese yen, Australian dollar, and Canadian dollar. As of January 2, 2022 and January 3, 2021, the total notional amounts of outstanding cash flow hedge contracts in place for these foreign currency purchases were $450 million and $305 million, respectively. There were no outstanding cash flow hedge contracts in place as of December 29, 2019.
Warranties We generally provide a one-year warranty on instruments. Additionally, we provide a warranty on consumables through the expiration date, which generally ranges from six to twelve months after the manufacture date. At the time revenue is recognized, an accrual is established for estimated warranty expenses based on historical experience as well as anticipated product performance. We periodically review the warranty reserve for adequacy and adjust the warranty accrual, if necessary, based on actual experience and estimated costs to be incurred. Warranty expense is recorded as a component of cost of product revenue.
Share-Based Compensation
Share-based compensation expense is incurred related to restricted stock, cash-based equity incentive awards, Employee Stock Purchase Plan (ESPP), and stock options.

Restricted stock units (RSU) and performance stock units (PSU) are both considered restricted stock. The fair value of restricted stock is determined by the closing market price of our common stock on the date of grant. Share-based compensation expense is recognized based on the fair value on a straight-line basis over the requisite service periods of the awards. PSU represents a right to receive a certain number of shares of common stock based on the achievement of corporate performance goals and continued employment during the vesting period. At each reporting period, we reassess the probability of the achievement of such corporate performance goals and any increase or decrease in share-based compensation expense resulting from an adjustment in the estimated shares to be released is treated as a cumulative catch-up in the period of adjustment.

Cash-based equity incentive awards are classified as liability awards, as such awards will be settled in cash. The cash to be awarded may increase or decrease in direct correlation to changes in the enterprise fair value of GRAIL, as defined under the Cash-Based Equity Appreciation Award Plan. The fair value of the awards is recorded over the respective vesting periods of the awards, with recognition of a corresponding liability recorded in accrued liabilities in the consolidated balance sheets. The awards are remeasured to fair value at each reporting date until the award is settled, with changes in fair value recognized in share-based compensation expense.

The Black-Scholes-Merton option-pricing model is used to estimate the fair value of stock purchased under our ESPP and stock options granted. The model assumptions include expected volatility, term, dividends, and the risk-free interest rate. The expected volatility is determined by equally weighing the historical and implied volatility of our common stock. The historical volatility is generally commensurate with the estimated expected term, adjusted for the impact of unusual fluctuations and other relevant factors. The implied volatility is calculated from the implied market volatility of exchange-traded call options on our common stock. The expected term is based on historical forfeiture experience, exercise activity, and on the terms and conditions of the stock awards. The expected dividend yield is determined to be 0% given that we have never declared or paid cash dividends on our common stock and do not anticipate paying such cash dividends. The risk-free interest rate is based upon U.S. Treasury securities with remaining terms similar to the expected term of the share-based awards.
Forfeitures are accounted for, as incurred, as a reversal of share-based compensation expense related to awards that will not vest.
Research and Development Research and development expenses include personnel expenses, contractor fees, facilities-related costs, material costs, and license fees. Expenditures relating to research and development are expensed in the period incurred.
Advertising Costs Advertising costs are expensed as incurred.
Income Taxes
The provision for income taxes is computed using the asset and liability method, under which deferred tax assets and liabilities are recognized for the expected future tax consequences of temporary differences between the financial reporting and tax bases of assets and liabilities, and for the expected future tax benefit to be derived from tax loss and credit carryforwards. Deferred tax assets and liabilities are determined using the enacted tax rates in effect for the years in which those tax assets are expected to be realized. The effect of a change in tax rates on deferred tax assets and liabilities is recognized in the provision for income taxes in the period that includes the enactment date.

Deferred tax assets are regularly assessed to determine the likelihood they will be recovered from future taxable income. A valuation allowance is established when we believe it is more likely than not the future realization of all or some of a deferred tax asset will not be achieved. In evaluating the ability to recover deferred tax assets within the jurisdiction which they arise, we consider all available positive and negative evidence. Factors reviewed include the cumulative pre-tax book income for the past three years, scheduled reversals of deferred tax liabilities, history of earnings and reliable forecasting, projections of pre-tax book income over the foreseeable future, and the impact of any feasible and prudent tax planning strategies.
The impact of a tax position is recognized in the consolidated financial statements only if that position is more likely than not of being sustained upon examination by taxing authorities, based on the technical merits of the position. Any interest and penalties related to uncertain tax positions will be reflected in income tax expense.
v3.22.0.1
Organization and Significant Accounting Policies (Tables)
12 Months Ended
Jan. 02, 2022
Accounting Policies [Abstract]  
Schedule of Calculation of Weighted Average Shares used to Calculate Basic and Diluted Earnings Per Share, Earnings Per Share
The following table presents the calculation of weighted average shares used to calculate basic and diluted earnings per share:
 Years Ended
In millionsJanuary 2,
2022
January 3,
2021
December 29,
2019
Weighted average shares outstanding150 147 147 
Effect of potentially dilutive common shares from:
Equity awards1 
Convertible senior notes — 
Weighted average shares used in calculating diluted earnings per share
151 148 149 
Schedule of Estimated Useful Lives of Major Classes of Property and Equipment
The estimated useful lives of the major classes of property and equipment are generally as follows:
Estimated Useful Lives
Buildings and leasehold improvements
4 to 20 years
Machinery and equipment
3 to 5 years
Computer hardware and software
3 to 9 years
Furniture and fixtures
7 years
in millionsJanuary 2,
2022
January 3,
2021
Leasehold improvements$724 $645 
Machinery and equipment513 461 
Computer hardware and software377 305 
Furniture and fixtures49 46 
Buildings44 44 
Construction in progress113 99 
Total property and equipment, gross1,820 1,600 
Accumulated depreciation(796)(678)
Total property and equipment, net$1,024 $922 
v3.22.0.1
Revenue (Tables)
12 Months Ended
Jan. 02, 2022
Revenue from Contract with Customer [Abstract]  
Schedule of Disaggregation of Revenue
Revenue by Source

202120202019
in millionsSequencingMicroarrayTotalSequencingMicroarrayTotalSequencingMicroarrayTotal
Consumables$2,911 $306 $3,217 $2,039 $265 $2,304 $2,075 $317 $2,392 
Instruments734 17 751 417 14 431 517 20 537 
Total product revenue3,645 323 3,968 2,456 279 2,735 2,592 337 2,929 
Service and other revenue464 94 558 423 81 504 476 138 614 
Total revenue$4,109 $417 $4,526 $2,879 $360 $3,239 $3,068 $475 $3,543 

Revenue by Geographic Area

Based on region of destination (in millions)202120202019
Americas (1)
$2,358 $1,744 $1,970 
Europe, Middle East, and Africa1,289 886 933 
Greater China (2)
502 342 372 
Asia-Pacific377 267 268 
Total revenue$4,526 $3,239 $3,543 
_____________
(1)Revenue for the Americas region included United States revenue of $2,195 million, $1,655 million, and $1,859 million in 2021, 2020, and 2019, respectively.
(2)Region includes revenue from China, Taiwan, and Hong Kong.
v3.22.0.1
Investments and Fair Value Measurements (Tables)
12 Months Ended
Jan. 02, 2022
Fair Value Disclosures [Abstract]  
Schedule of Short-term Investments
 January 3, 2021
In millions
 Amortized
Cost
Gross
Unrealized
Gains
 
Estimated
Fair Value
Debt securities in government-sponsored entities
$10 $— $10 
Corporate debt securities445 — 445 
U.S. Treasury securities830 831 
Total
$1,285 $$1,286 
Schedule of Marketable Securities
Gains and losses recognized in other income, net on our marketable equity securities for 2021, 2020, and 2019 were as follows:

In millions202120202019
Net (losses) gains recognized during the period on marketable equity securities$(52)$270 $53 
Less: Net losses recognized during the period on marketable equity securities sold during the period89 — — 
Net unrealized gains recognized during the period on marketable equity securities still held at the reporting date$37 $270 $53 
Schedule of Fair Value Hierarchy for Assets and Liabilities Measured at Fair Value on a Recurring Basis
The following table presents the hierarchy for assets and liabilities measured at fair value on a recurring basis:
January 2, 2022January 3, 2021
In millionsLevel 1Level 2Level 3TotalLevel 1Level 2Level 3Total
Assets:
Money market funds (cash equivalents)$688 $ $ $688 $1,512 $— $— $1,512 
Debt securities in government-sponsored entities    — 10 — 10 
Corporate debt securities    — 445 — 445 
U.S. Treasury securities    831 — — 831 
Marketable equity securities107   107 376 — — 376 
Helix contingent value right  65 65 — — 35 35 
Derivative assets related to terminated acquisition    — — 26 26 
Deferred compensation plan assets 60  60 — 55 — 55 
Total assets measured at fair value$795 $60 $65 $920 $2,719 $510 $61 $3,290 
Liabilities:
Contingent consideration liabilities$ $ $615 $615 $— $— $— $— 
Deferred compensation plan liability 56  56 — 51 — 51 
Total liabilities measured at fair value$ $56 $615 $671 $— $51 $— $51 
Schedule of Changes in Estimated Fair Value of Acquisition Related Contingent Consideration Liabilities
Changes in the estimated fair value of contingent consideration liabilities during 2021 were as follows:
In millions
Balance as of January 3, 2021
$ 
Acquisition of GRAIL762 
Other acquisition14 
Measurement period adjustment(5)
Cash payments(15)
Exchange of GRAIL contingent value rights(145)
Change in estimated fair value4 
Balance as of January 2, 2022
$615 
v3.22.0.1
Acquisitions, Goodwill and Intangible Assets (Tables)
12 Months Ended
Jan. 02, 2022
Business Combination And Goodwill And Intangible Assets [Abstract]  
Schedule of Total Purchase Price
The total purchase price consisted of the following:

in millionsAs Adjusted
Cash$2,862 
Fair value of common stock issued4,975 
Fair value of contingent consideration757 
Fair value of previously held investment1,149 
Settlement of preexisting relationships2 
Total purchase price$9,745 
Schedule of Preliminary Fair Value of Assets Acquired and Liabilities Assumed
The preliminary fair values of assets acquired and liabilities assumed were:
in millionsAs Initially ReportedMeasurement Period AdjustmentsAs Adjusted
Cash and cash equivalents$571 $— $571 
Property and equipment89 — 89 
Operating lease right-of-use assets121 — 121 
Goodwill6,082 15 6,097 
Intangible assets3,180 (60)3,120 
Other current and noncurrent assets35 — 35 
Deferred tax liability(82)40 (42)
Long-term lease liabilities(97)— (97)
Other current and noncurrent liabilities(148)(1)(149)
Total net assets acquired$9,751 $(6)$9,745 
Schedule of Finite-Lived and Indefinite-Lived Intangible Assets Acquired as Part of Business Combination
The preliminary fair values assigned to identifiable intangible assets acquired were as follows:

in millions, except yearsFair Value
(as adjusted)
Estimated Useful Life
Developed technology$2,410 18
Trade name40 9
In-process research and development (IPR&D)670 Indefinite
Total intangible assets$3,120 
Schedule of Unaudited Pro Forma Information
The following unaudited pro forma financial information summarizes the combined results of operations of Illumina and GRAIL as if the companies had been combined as of the beginning of our fiscal year 2020.

in millions20212020
Revenue$4,528 $3,239 
Net income$661 $351 
Schedule of Goodwill
Goodwill
In millionsGoodwill
Balance as of December 29, 2019$824 
Acquisitions73 
Balance as of January 3, 2021897 
Acquisitions6,201 
Measurement period adjustments15 
Balance as of January 2, 2022$7,113 
Schedule of Finite-lived Intangible Assets
 January 2, 2022January 3, 2021
In millionsGross
Carrying
Amount
Accumulated
Amortization
Intangible Assets,
Net
Gross
Carrying
Amount
Accumulated
Amortization
Intangible Assets,
Net
Developed technologies$2,790 $(291)$2,499 $352 $(221)$131 
Licensed technologies95 (92)3 95 (91)
Trade name44 (6)38 (4)— 
Customer relationships31 (28)3 31 (27)
License agreements14 (12)2 14 (11)
Total finite-lived intangible assets, net2,974 (429)2,545 496 (354)142 
In-process research and development (IPR&D)705  705 — — — 
Total intangible assets, net$3,679 $(429)$3,250 $496 $(354)$142 
Schedule of Estimated Annual Amortization of Finite-lived Intangible Assets
The estimated future annual amortization of finite-lived intangible assets is shown in the following table. Actual amortization expense to be reported in future periods could differ from these estimates as a result of acquisitions, divestitures, and asset impairments, among other factors.

In millionsEstimated Annual Amortization
2022$165 
2023164 
2024162 
2025162 
2026151 
Thereafter1,741 
Total$2,545 
v3.22.0.1
Debt and Other Commitments (Tables)
12 Months Ended
Jan. 02, 2022
Debt Disclosure [Abstract]  
Schedule of Debt Obligations
Summary of Term Debt Obligations
In millionsJanuary 2,
2022
Principal amount of 2031 Term Notes outstanding$500 
Principal amount of 2023 Term Notes outstanding500 
Unamortized discounts and debt issuance costs(7)
Net carrying amount of term notes993 
Less: current portion 
Term notes, non-current$993 
Fair value of term notes outstanding (Level 2)$996 
Summary of Convertible Debt Obligations
In millionsJanuary 2,
2022
January 3,
2021
Principal amount of 2023 Convertible Senior Notes outstanding$750 $750 
Principal amount of 2021 Convertible Senior Notes outstanding 517 
Unamortized discount of liability component of convertible senior notes(48)(83)
       Net carrying amount of liability component of convertible senior notes702 1,184 
Less: current portion (511)
Convertible senior notes, non-current$702 $673 
Carrying value of equity component of convertible senior notes, net of debt issuance costs
$126 $213 
Fair value of convertible senior notes outstanding (Level 2)$854 $1,595 
Weighted-average remaining amortization period of discount on the liability component of convertible senior notes1.6 years2.4 years

Interest expense recognized on the Convertible Senior Notes, which included amortization of debt discounts and issuance costs, was $36 million, $46 million, and $51 million in 2021, 2020, and 2019, respectively.
Schedule of Debt Conversions The following table summarizes information about the conversions during 2021:
In millions2021 Notes
Cash paid for principal of notes converted$517 
Conversion value over principal amount, paid in shares of common stock$313 
Number of shares of common stock issued upon conversion0.7 
Loss on extinguishment of debt$1 
Schedule of Leases
As of January 2, 2022, the maturities of our operating lease liabilities were as follows:
In millions
2022$103
2023101
2024112
2025105
2026103
Thereafter517
Total remaining lease payments (1)
1,041
Less: imputed interest(196)
Total operating lease liabilities845
Less: current portion(71)
Long-term operating lease liabilities$774
Weighted-average remaining lease term9.9 years
Weighted-average discount rate4.1 %
_____________
(1)Total remaining lease payments exclude $8 million of legally binding minimum lease payments for leases signed but not yet commenced.
Schedule of Components of Lease Costs
The components of our lease costs were as follows:
In millions202120202019
Operating lease costs$99 $84 $84 
Sublease income(16)(11)(12)
Total lease costs$83 $73 $72 
v3.22.0.1
Stockholders' Equity (Tables)
12 Months Ended
Jan. 02, 2022
Equity [Abstract]  
Schedule of Restricted Stock Activity and Related Information, Restricted Stock
Restricted stock activity was as follows:
Restricted
Stock Units
(RSU) (1)
Performance
Stock Units
(PSU)(2)
Weighted-Average Grant-
Date Fair Value per Share
Units in thousandsRSUPSU
Outstanding at December 30, 20181,840 660 $227.00 $196.99 
Awarded698 (41)$313.70 $254.52 
Vested(694)(283)$205.51 $133.11 
Cancelled(144)(65)$225.48 $181.79 
Outstanding at December 29, 20191,700 271 $271.49 $258.66 
Awarded878 (78)$329.83 $344.22 
Vested(655)(117)$239.19 $400.74 
Cancelled(202)(76)$273.13 $266.63 
Outstanding at January 3, 20211,721  $313.35 $ 
Awarded259 456 $438.46 $471.63 
Vested(606)(72)$303.08 $492.55 
Cancelled(244)(56)$321.93 $475.38 
Outstanding at January 2, 20221,130 328 $345.66 $466.42 
_____________
(1)In connection with the GRAIL acquisition, replacement awards of 59,000 RSU were awarded to GRAIL employees in 2021.
(2)The number of units reflect the estimated number of shares to be issued at the end of the performance period. Awarded units are presented net of performance adjustments.
Schedule of Restricted Stock Activity and Related Information, Performance Units
Restricted stock activity was as follows:
Restricted
Stock Units
(RSU) (1)
Performance
Stock Units
(PSU)(2)
Weighted-Average Grant-
Date Fair Value per Share
Units in thousandsRSUPSU
Outstanding at December 30, 20181,840 660 $227.00 $196.99 
Awarded698 (41)$313.70 $254.52 
Vested(694)(283)$205.51 $133.11 
Cancelled(144)(65)$225.48 $181.79 
Outstanding at December 29, 20191,700 271 $271.49 $258.66 
Awarded878 (78)$329.83 $344.22 
Vested(655)(117)$239.19 $400.74 
Cancelled(202)(76)$273.13 $266.63 
Outstanding at January 3, 20211,721  $313.35 $ 
Awarded259 456 $438.46 $471.63 
Vested(606)(72)$303.08 $492.55 
Cancelled(244)(56)$321.93 $475.38 
Outstanding at January 2, 20221,130 328 $345.66 $466.42 
_____________
(1)In connection with the GRAIL acquisition, replacement awards of 59,000 RSU were awarded to GRAIL employees in 2021.
(2)The number of units reflect the estimated number of shares to be issued at the end of the performance period. Awarded units are presented net of performance adjustments.
Schedule of Pre-tax Intrinsic Values of Vested Restricted Stock
Pre-tax intrinsic values and fair value of vested restricted stock was as follows:
In millions202120202019
Pre-tax intrinsic value of outstanding restricted stock:
RSU$430 $637 $565 
PSU$125 $— $90 
Fair value of restricted stock vested:
RSU$247 $206 $210 
PSU$35 $47 $38 
Schedule of Total Fair Value of Vested Restricted Stock
Pre-tax intrinsic values and fair value of vested restricted stock was as follows:
In millions202120202019
Pre-tax intrinsic value of outstanding restricted stock:
RSU$430 $637 $565 
PSU$125 $— $90 
Fair value of restricted stock vested:
RSU$247 $206 $210 
PSU$35 $47 $38 
Schedule of Stock Option Activity Under all Stock Option Plans
Stock option activity was as follows:
Units in thousandsOptionsWeighted-Average
Exercise Price
Performance Stock Options(1)
Weighted-Average
Exercise Price
Outstanding at December 30, 2018192 $54.52 — $— 
Exercised(134)$53.61 — $— 
Outstanding at December 29, 201958 $56.65 — $— 
Exercised(48)$56.16 — $— 
Outstanding at January 3, 202110 $59.11  $ 
Granted $ 48 $86.73 
Exercised(2)$20.06 (21)$86.72 
Cancelled $ (10)$89.63 
Outstanding at January 2, 20228 $66.42 17 $85.54 
_____________
(1)In connection with the GRAIL acquisition, we issued replacement performance stock options to GRAIL employees in 2021. The number of units reflect awards that have been granted and for which it is assumed to be probable that the underlying performance goals will be achieved.
Schedule of Share-based Compensation Expense for all Stock Awards
Share-based compensation expense, which includes expense for both equity and liability-classified awards, reported in our consolidated statements of income was as follows:
In millions202120202019
Cost of product revenue$23 $21 $19 
Cost of service and other revenue4 
Research and development276 74 66 
Selling, general and administrative638 95 105 
Share-based compensation expense, before taxes941 194 194 
Related income tax benefits(64)(43)(41)
Share-based compensation expense, net of taxes$877 $151 $153 
Schedule of Assumptions used to Estimate the Weighted-Average Fair Value Per Share for Stock Purchase under the Employee Stock Purchase Plan
The assumptions used for the specified reporting periods and the resulting estimates of weighted-average fair value per share for stock purchased under the ESPP were as follows:
202120202019
Risk-free interest rate
0.06% - 0.12%
 0.11% - 2.04%
1.88% - 2.56%
Expected volatility
37% - 47%
 30% - 45%
30% - 38%
Expected term
0.5 - 1.0 year
 0.5 - 1.0 year
0.5 - 1.0 year
Expected dividends
0%
0%0%
Weighted-average grant-date fair value per share$134.47 $75.57 $75.47 
v3.22.0.1
Supplemental Balance Sheet and Statement of Income Details (Tables)
12 Months Ended
Jan. 02, 2022
Organization, Consolidation and Presentation of Financial Statements [Abstract]  
Schedule of Accounts Receivable
in millionsJanuary 2,
2022
January 3,
2021
Trade accounts receivable, gross$651 $491 
Allowance for credit losses(3)(4)
Total accounts receivable, net$648 $487 
Schedule of Inventory
in millionsJanuary 2,
2022
January 3,
2021
Raw materials$92 $106 
Work in process312 244 
Finished goods27 22 
Total inventory$431 $372 
Schedule of Property and Equipment
The estimated useful lives of the major classes of property and equipment are generally as follows:
Estimated Useful Lives
Buildings and leasehold improvements
4 to 20 years
Machinery and equipment
3 to 5 years
Computer hardware and software
3 to 9 years
Furniture and fixtures
7 years
in millionsJanuary 2,
2022
January 3,
2021
Leasehold improvements$724 $645 
Machinery and equipment513 461 
Computer hardware and software377 305 
Furniture and fixtures49 46 
Buildings44 44 
Construction in progress113 99 
Total property and equipment, gross1,820 1,600 
Accumulated depreciation(796)(678)
Total property and equipment, net$1,024 $922 
Schedule of Accrued Liabilities
in millionsJanuary 2,
2022
January 3,
2021
Accrued compensation expenses$252 $153 
Contract liabilities, current portion234 186 
Accrued taxes payable98 68 
Operating lease liabilities, current portion71 51 
Contingent consideration liabilities, current portion1 — 
Other, including warranties (a)105 83 
Total accrued liabilities$761 $541 

(a) Changes in the reserve for product warranties were as follows:
in millions
Balance as of December 30, 2018$19 
Additions charged to cost of product revenue20 
Repairs and replacements(25)
Balance as of December 29, 201914 
Additions charged to cost of product revenue20 
Repairs and replacements(21)
Balance as of January 3, 202113 
Additions charged to cost of product revenue33 
Repairs and replacements(24)
Balance as of January 2, 2022$22 
Schedule of Changes in Reserve for Product Warranties Changes in the reserve for product warranties were as follows:
in millions
Balance as of December 30, 2018$19 
Additions charged to cost of product revenue20 
Repairs and replacements(25)
Balance as of December 29, 201914 
Additions charged to cost of product revenue20 
Repairs and replacements(21)
Balance as of January 3, 202113 
Additions charged to cost of product revenue33 
Repairs and replacements(24)
Balance as of January 2, 2022$22 
Schedule of Other Nonoperating Income (Expense)
Other Income, Net

in millions202120202019
Gain on previously held investment in GRAIL$899 $— $— 
Gain on exchange of GRAIL contingent value rights86 — — 
Gain (loss) on Helix contingent value right30 (1)
Gain (loss) on derivative assets related to terminated acquisition26 (25)— 
Gains on strategic investments, net18 291 62 
Gains on deconsolidations — 54 
Other9 11 (5)
Other income, net$1,068 $284 $110 
v3.22.0.1
Income Taxes (Tables)
12 Months Ended
Jan. 02, 2022
Income Tax Disclosure [Abstract]  
Schedule of Income (Loss) before Income Taxes by Region
Income (loss) before income taxes summarized by region was as follows:
In millions202120202019
United States$(115)$313 $242 
Foreign999 543 876 
Total income before income taxes$884 $856 $1,118 
Schedule of Provision for Income Taxes
The provision for income taxes consisted of the following:
In millions202120202019
Current:   
Federal$54 $25 $32 
State37 13 
Foreign107 45 84 
Total current provision$198 $83 $123 
Deferred:
Federal$(50)$30 $
State(23)94 (1)
Foreign(3)(7)
Total deferred (benefit) expense(76)117 
Total tax provision$122 $200 $128 
Schedule of Reconciliation of Provision for Income Taxes to Amount Computed by Applying the Federal Statutory Rate
The provision for income taxes reconciles to the amount computed by applying the federal statutory rate to income before taxes as follows:
In millions202120202019
Tax at federal statutory rate$186 $180 $235 
State, net of federal benefit13 19 18 
Research and other credits(23)(19)(37)
Change in valuation allowance33 69 (2)
Impact of foreign operations(80)(47)(57)
Impact of foreign derived intangible income (FDII) deduction(12)(11)(4)
Cost sharing adjustment 28 — 
Investments in consolidated variable interest entities (2)(5)
Stock compensation(10)(18)(20)
Officer compensation13 
Impact of acquisition related items(16)— — 
Other18 (6)(5)
Total tax provision$122 $200 $128 
Schedule of Significant Components of Deferred Tax Assets and Liabilities
Significant components of deferred tax assets and liabilities were as follows:
In millionsJanuary 2,
2022
January 3,
2021
Deferred tax assets:  
Net operating losses$513 $26 
Tax credits128 70 
Other accruals and reserves39 21 
Stock compensation23 17 
Other amortization225 17 
Operating lease liabilities173 156 
Other36 53 
Total gross deferred tax assets1,137 360 
Valuation allowance on deferred tax assets(134)(81)
Total deferred tax assets
$1,003 $279 
Deferred tax liabilities:  
Purchased intangible amortization$(828)$(27)
Convertible debt(11)(20)
Property and equipment(21)(34)
Operating lease right-of-use assets(129)(108)
Investments(29)(137)
Other(12)(6)
Total deferred tax liabilities(1,030)(332)
Deferred tax liabilities, net$(27)$(53)
Schedule of the Gross Amount of Uncertain Tax Positions
The following table summarizes the gross amount of our uncertain tax positions:
In millionsJanuary 2,
2022
January 3,
2021
December 29,
2019
Balance at beginning of year$80 $79 $88 
Increases related to prior year tax positions19 
Decreases related to prior year tax positions(1)— — 
Increases related to current year tax positions39 12 12 
Decreases related to lapse of statute of limitations(6)(13)(22)
Balance at end of year$131 $80 $79 
v3.22.0.1
Segments and Geographic Data (Tables)
12 Months Ended
Jan. 02, 2022
Segment Reporting [Abstract]  
Schedule of Operating Performance and Assets by Segment
 In millions202120202019
Revenue:
Core Illumina$4,519 $3,239 $3,543 
GRAIL12 — — 
Helix — 
Eliminations(5)— (1)
Consolidated revenue$4,526 $3,239 $3,543 
Depreciation and amortization:
Core Illumina$200 $187 $186 
GRAIL51 — — 
Helix — 
Eliminations  — (1)
Consolidated depreciation and amortization$251 $187 $188 
Income (loss) from operations:
Core Illumina$808 $580 $1,008 
GRAIL(931)— — 
Helix — (24)
Eliminations — 
Consolidated (loss) income from operations$(123)$580 $985 

Total other income, net primarily relates to Core Illumina and we do not allocate income taxes to our segments.

In millionsJanuary 2,
2022
January 3,
2021
December 29,
2019
Total assets:
Core Illumina$5,571 $7,585 $7,316 
GRAIL9,649 — — 
Helix — — 
Eliminations(3)— — 
Consolidated total assets$15,217 $7,585 $7,316 
Capital expenditures:
Core Illumina$201 $189 $209 
GRAIL8 — — 
Eliminations(1)— — 
Consolidated capital expenditures$208 $189 $209 
Schedule of Net Long-lived Assets Consisting of Property and Equipment by Region Net long-lived assets, consisting of property and equipment and operating lease right-of-use assets, by region, were as follows:
In millionsJanuary 2,
2022
January 3,
2021
United States$1,281 $1,134 
Singapore218 150 
United Kingdom146 141 
Other countries51 29 
Total net long-lived assets$1,696 $1,454 
v3.22.0.1
Organization and Significant Accounting Policies - Narrative - Concentrations of Risk (Details)
12 Months Ended
Jan. 02, 2022
Jan. 03, 2021
Dec. 29, 2019
Credit Concentration Risk | Investment Portfolio      
Concentration Risk [Line Items]      
Maximum investment portfolio credit exposure 5.00%    
Credit Concentration Risk | Issue Size      
Concentration Risk [Line Items]      
Maximum investment portfolio credit exposure 5.00%    
Industry Credit Concentration Risk | Investment Portfolio      
Concentration Risk [Line Items]      
Maximum investment portfolio credit exposure 30.00%    
Outside the United States | Geographic Concentration Risk | Sales Revenue, Net      
Concentration Risk [Line Items]      
Concentration percent 52.00% 49.00% 48.00%
Outside the United States | Geographic Concentration Risk | Accounts Receivable      
Concentration Risk [Line Items]      
Concentration percent 57.00% 56.00%  
v3.22.0.1
Organization and Significant Accounting Policies - Narrative - Revenue Recognition (Details)
12 Months Ended
Jan. 02, 2022
Product revenue  
Revenue from External Customer [Line Items]  
Payment period from invoice 60 days
v3.22.0.1
Organization and Significant Accounting Policies - Summary of Calculation of Weighted Average Shares used to Calculate Basic and Diluted Earnings Per Share (Details) - shares
shares in Millions
12 Months Ended
Jan. 02, 2022
Jan. 03, 2021
Dec. 29, 2019
Weighted average shares used to calculate basic and diluted net income per share [Line Items]      
Weighted average shares outstanding (in shares) 150 147 147
Effect of potentially dilutive common shares from:      
Equity awards (in shares) 1 1 1
Convertible senior notes (in shares) 0 0 1
Weighted average shares used in calculating diluted earnings per share (in shares) 151 148 149
v3.22.0.1
Organization and Significant Accounting Policies - Summary of Estimated Useful Lives of Major Classes of Property and Equipment (Details)
12 Months Ended
Jan. 02, 2022
Buildings and leasehold improvements | Minimum  
Property, Plant and Equipment [Line Items]  
Useful life 4 years
Buildings and leasehold improvements | Maximum  
Property, Plant and Equipment [Line Items]  
Useful life 20 years
Machinery and equipment | Minimum  
Property, Plant and Equipment [Line Items]  
Useful life 3 years
Machinery and equipment | Maximum  
Property, Plant and Equipment [Line Items]  
Useful life 5 years
Computer hardware and software | Minimum  
Property, Plant and Equipment [Line Items]  
Useful life 3 years
Computer hardware and software | Maximum  
Property, Plant and Equipment [Line Items]  
Useful life 9 years
Furniture and fixtures | Minimum  
Property, Plant and Equipment [Line Items]  
Useful life 7 years
v3.22.0.1
Organization and Significant Accounting Policies - Narrative - Leases (Details)
ft² in Millions
Jan. 02, 2022
ft²
Property, Plant and Equipment [Line Items]  
Lessee operating lease, area 3
Minimum  
Property, Plant and Equipment [Line Items]  
Lessee, operating lease, remaining lease term 1 year
Lessee, operating lease, renewal term 6 months
Maximum  
Property, Plant and Equipment [Line Items]  
Lessee, operating lease, remaining lease term 18 years
Lessee, operating lease, renewal term 20 years
v3.22.0.1
Organization and Significant Accounting Policies - Narrative - Derivatives (Details) - USD ($)
$ in Millions
12 Months Ended
Jan. 02, 2022
Jan. 03, 2021
Derivative Instruments, Gain (Loss) [Line Items]    
Derivative term 24 months  
Foreign Exchange Forward | Not Designated as Hedging Instrument    
Derivative Instruments, Gain (Loss) [Line Items]    
Notional amount of outstanding forward contracts $ 462 $ 405
Foreign Exchange Forward | Designated as Hedging Instrument    
Derivative Instruments, Gain (Loss) [Line Items]    
Notional amount of outstanding forward contracts $ 450 $ 305
v3.22.0.1
Organization and Significant Accounting Policies - Narrative - Warranties (Details)
12 Months Ended
Jan. 02, 2022
Instruments  
Product Warranty Liability [Line Items]  
Warranty period 1 year
Consumables | Minimum  
Product Warranty Liability [Line Items]  
Warranty period 6 months
Consumables | Maximum  
Product Warranty Liability [Line Items]  
Warranty period 12 months
v3.22.0.1
Organization and Significant Accounting Policies - Narrative - Share-Based Compensation (Details)
12 Months Ended
Jan. 02, 2022
Accounting Policies [Abstract]  
Expected dividend yield 0.00%
v3.22.0.1
Organization and Significant Accounting Policies - Narrative - Advertising Costs (Details) - USD ($)
$ in Millions
12 Months Ended
Jan. 02, 2022
Jan. 03, 2021
Dec. 29, 2019
Accounting Policies [Abstract]      
Advertising costs $ 48 $ 28 $ 28
v3.22.0.1
Organization and Significant Accounting Policies - Narrative - Recently Adopted Accounting Policies (Details) - USD ($)
$ in Millions
Jan. 03, 2022
Jan. 02, 2022
Jan. 03, 2021
Dec. 31, 2018
New Accounting Pronouncements or Change in Accounting Principle [Line Items]        
Retained earnings (accumulated deficit)   $ 5,485 $ 4,723  
Deferred tax liabilities   (27) (53)  
Additional paid-in capital   $ (8,938) $ (3,815)  
Accounting Standards Update 2016-02 | Cumulative Effect, Period of Adoption, Adjustment        
New Accounting Pronouncements or Change in Accounting Principle [Line Items]        
Retained earnings (accumulated deficit)       $ 18
ASU 2020-06 | Cumulative Effect, Period of Adoption, Adjustment | Subsequent Event        
New Accounting Pronouncements or Change in Accounting Principle [Line Items]        
Retained earnings (accumulated deficit) $ 61      
Convertible debt 43      
Deferred tax liabilities 11      
Additional paid-in capital $ 93      
v3.22.0.1
Revenue - Summary of Disaggregated Revenue (Details) - USD ($)
$ in Millions
12 Months Ended
Jan. 02, 2022
Jan. 03, 2021
Dec. 29, 2019
Revenue from External Customer [Line Items]      
Revenue $ 4,526 $ 3,239 $ 3,543
Americas      
Revenue from External Customer [Line Items]      
Revenue 2,358 1,744 1,970
Europe, Middle East, and Africa      
Revenue from External Customer [Line Items]      
Revenue 1,289 886 933
Greater China      
Revenue from External Customer [Line Items]      
Revenue 502 342 372
Asia-Pacific      
Revenue from External Customer [Line Items]      
Revenue 377 267 268
United States      
Revenue from External Customer [Line Items]      
Revenue 2,195 1,655 1,859
Total product revenue      
Revenue from External Customer [Line Items]      
Revenue 3,968 2,735 2,929
Consumables      
Revenue from External Customer [Line Items]      
Revenue 3,217 2,304 2,392
Instruments      
Revenue from External Customer [Line Items]      
Revenue 751 431 537
Service and other revenue      
Revenue from External Customer [Line Items]      
Revenue 558 504 614
Sequencing      
Revenue from External Customer [Line Items]      
Revenue 4,109 2,879 3,068
Sequencing | Total product revenue      
Revenue from External Customer [Line Items]      
Revenue 3,645 2,456 2,592
Sequencing | Consumables      
Revenue from External Customer [Line Items]      
Revenue 2,911 2,039 2,075
Sequencing | Instruments      
Revenue from External Customer [Line Items]      
Revenue 734 417 517
Sequencing | Service and other revenue      
Revenue from External Customer [Line Items]      
Revenue 464 423 476
Microarray      
Revenue from External Customer [Line Items]      
Revenue 417 360 475
Microarray | Total product revenue      
Revenue from External Customer [Line Items]      
Revenue 323 279 337
Microarray | Consumables      
Revenue from External Customer [Line Items]      
Revenue 306 265 317
Microarray | Instruments      
Revenue from External Customer [Line Items]      
Revenue 17 14 20
Microarray | Service and other revenue      
Revenue from External Customer [Line Items]      
Revenue $ 94 $ 81 $ 138
v3.22.0.1
Revenue - Remaining Performance Obligation (Details)
$ in Millions
12 Months Ended
Jan. 02, 2022
USD ($)
Revenue from Contract with Customer [Abstract]  
Remaining performance obligation $ 1,035
Minimum  
Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction [Line Items]  
Product or service delivery period 3 years
Maximum  
Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction [Line Items]  
Product or service delivery period 6 months
Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Start Date [Axis]: 2022-01-03  
Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction [Line Items]  
Percent of remaining performance obligation 89.00%
Revenue, remaining performance obligation, expected timing of satisfaction, period 12 months
Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Start Date [Axis]: 2023-01-02  
Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction [Line Items]  
Percent of remaining performance obligation 9.00%
Revenue, remaining performance obligation, expected timing of satisfaction, period 12 months
v3.22.0.1
Revenue - Narrative (Details) - USD ($)
$ in Millions
12 Months Ended
Jan. 02, 2022
Jan. 03, 2021
Revenue from Contract with Customer [Abstract]    
Contract asset $ 16 $ 15
Contract asset, current portion 16 14
Contract liability 297 230
Contract liabilities, current portion 234 $ 186
Revenue recognized, previously deferred $ 183  
v3.22.0.1
Investments and Fair Value Measurements - Summary of Short-term Investments (Details)
$ in Millions
Jan. 03, 2021
USD ($)
Debt Securities, Available-for-sale [Line Items]  
Amortized Cost $ 1,285
Gross Unrealized Gains 1
Estimated Fair Value 1,286
Debt securities in government-sponsored entities  
Debt Securities, Available-for-sale [Line Items]  
Amortized Cost 10
Gross Unrealized Gains 0
Estimated Fair Value 10
Corporate debt securities  
Debt Securities, Available-for-sale [Line Items]  
Amortized Cost 445
Gross Unrealized Gains 0
Estimated Fair Value 445
U.S. Treasury securities  
Debt Securities, Available-for-sale [Line Items]  
Amortized Cost 830
Gross Unrealized Gains 1
Estimated Fair Value $ 831
v3.22.0.1
Investments and Fair Value Measurements - Narrative (Details)
3 Months Ended 12 Months Ended
Aug. 18, 2021
USD ($)
Jan. 02, 2020
USD ($)
Apr. 25, 2019
USD ($)
Nov. 01, 2018
USD ($)
$ / shares
Jan. 02, 2022
USD ($)
Jul. 04, 2021
USD ($)
Mar. 29, 2020
USD ($)
Dec. 29, 2019
USD ($)
Jan. 02, 2022
USD ($)
venture
Jan. 03, 2021
USD ($)
Dec. 29, 2019
USD ($)
Feb. 28, 2021
USD ($)
Jul. 31, 2015
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]                          
Marketable equity securities         $ 107,000,000       $ 107,000,000 $ 376,000,000      
Strategic equity investments, without readily determinable fair values         40,000,000       40,000,000 314,000,000      
Gains on deconsolidation                 0 0 $ 54,000,000    
Gain (loss) on Helix contingent value right                 30,000,000 7,000,000 (1,000,000)    
(Gain) loss on derivative assets related to terminated acquisition                 (26,000,000) 25,000,000 0    
Measurement period adjustment                 (5,000,000)        
Change in fair value of contingent consideration liabilities                 4,000,000 0 0    
Business Combination, Contingent Consideration, Liability                          
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]                          
Change in estimated fair value                 4,000,000        
Cash payments         (15,000,000)       15,000,000        
PacBio                          
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]                          
Cash       $ 1,200,000,000                  
Share price (in dollars per share) | $ / shares       $ 8.00                  
Payment of contingent consideration             $ 132,000,000            
Equity or debt financing to be raised   $ 100,000,000                      
Derivative assets related to terminated acquisition               $ 10,000,000   40,000,000 10,000,000    
PacBio | Reverse Termination Fee                          
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]                          
Payment of contingent consideration   $ 98,000,000                      
Period for contingent consideration to be repayable   2 years                      
PacBio | Continuation Advances                          
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]                          
Payment of contingent consideration             34,000,000 18,000,000          
Period for contingent consideration to be repayable   2 years                      
Maximum amount payable to PacBio   $ 52,000,000                      
PacBio | Selling, general and administrative                          
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]                          
(Gain) loss on derivative assets related to terminated acquisition             $ 92,000,000 $ 8,000,000          
PacBio | Other Operating Income Expense                          
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]                          
Unrealized gain (loss) on derivatives                   (25,000,000)      
GRAIL                          
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]                          
Payments to acquire additional investments                   60,000,000      
SB Northstar LP                          
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]                          
Maximum amount payable to PacBio                       $ 52,000,000  
Series of Individually Immaterial Business Acquisitions                          
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]                          
Fair value of contingent consideration           $ 14,000,000              
Change in fair value of contingent consideration liabilities                 (1,000,000)        
GRAIL Inc                          
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]                          
Cash $ 2,862,000,000                        
Measurement period adjustment         (5,000,000)                
Change in estimated fair value                 7,000,000        
Fair value of contingent consideration $ 757,000,000                        
Change in fair value of contingent consideration liabilities         5,000,000       3,000,000        
Helix Holdings I, LLC                          
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]                          
Gains on deconsolidation     $ 39,000,000                    
Contingent value right     $ 30,000,000                    
Gain (loss) on Helix contingent value right                 30,000,000 7,000,000 (1,000,000)    
PacBio | SB Northstar LP                          
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]                          
(Gain) loss on derivative assets related to terminated acquisition                 $ (26,000,000)        
PacBio | SB Northstar LP | Convertible Senior Notes                          
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]                          
Principal amount of notes outstanding                       $ 900,000,000  
Venture Capital Investment Fund (the Fund)                          
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]                          
Number of venture capital investment funds | venture                 2        
Equity method investments         173,000,000       $ 173,000,000 104,000,000      
Unrealized gain on equity method investments                 55,000,000 20,000,000 9,000,000    
Venture Capital Investment Fund (the Fund), One                          
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]                          
Commitment in new venture capital investment fund         100,000,000       100,000,000        
Remaining capital commitment         20,000,000       20,000,000        
Venture Capital Investment Fund (the Fund), Two                          
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]                          
Commitment in new venture capital investment fund         150,000,000       150,000,000        
Remaining capital commitment         $ 118,000,000       118,000,000        
Investee                          
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]                          
Revenue from transactions with strategic investees                 $ 74,000,000 62,000,000 $ 71,000,000    
Variable Interest Entity, Not Primary Beneficiary | GRAIL                          
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]                          
Net assets                   $ 250,000,000      
Variable Interest Entity, Primary Beneficiary | Helix Holdings I, LLC                          
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]                          
Absorbed Helix's losses percentage                     50.00%    
Variable Interest Entity, Primary Beneficiary | Helix Holdings I, LLC                          
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]                          
Equity ownership interest percentage                         50.00%
v3.22.0.1
Investments and Fair Value Measurements - Marketable Equity Securities (Details) - USD ($)
$ in Millions
12 Months Ended
Jan. 02, 2022
Jan. 03, 2021
Dec. 29, 2019
Marketable Securities, Gain (Loss) [Abstract]      
Net (losses) gains recognized during the period on marketable equity securities $ (52) $ 270 $ 53
Less: Net losses recognized during the period on marketable equity securities sold during the period 89 0 0
Net unrealized gains recognized during the period on marketable equity securities still held at the reporting date $ 37 $ 270 $ 53
v3.22.0.1
Investments and Fair Value Measurements - Summary of Hierarchy for Assets and Liabilities Measured at Fair Value Recurring Basis (Details) - USD ($)
$ in Millions
Jan. 02, 2022
Jan. 03, 2021
Assets:    
Available-for-sale securities   $ 1,286
Marketable equity securities $ 107 376
Debt securities in government-sponsored entities    
Assets:    
Available-for-sale securities   10
Corporate debt securities    
Assets:    
Available-for-sale securities   445
U.S. Treasury securities    
Assets:    
Available-for-sale securities   831
Fair value, Measurements, Recurring    
Assets:    
Marketable equity securities 107 376
Helix contingent value right 65 35
Derivative assets related to terminated acquisition 0 26
Deferred compensation plan assets 60 55
Total assets measured at fair value 920 3,290
Liabilities:    
Contingent consideration liabilities 615 0
Deferred compensation plan liability 56 51
Total liabilities measured at fair value 671 51
Fair value, Measurements, Recurring | Money market funds (cash equivalents)    
Assets:    
Money market funds (cash equivalents) 688 1,512
Fair value, Measurements, Recurring | Debt securities in government-sponsored entities    
Assets:    
Available-for-sale securities 0 10
Fair value, Measurements, Recurring | Corporate debt securities    
Assets:    
Available-for-sale securities 0 445
Fair value, Measurements, Recurring | U.S. Treasury securities    
Assets:    
Available-for-sale securities 0 831
Fair value, Measurements, Recurring | Level 1    
Assets:    
Marketable equity securities 107 376
Helix contingent value right 0 0
Derivative assets related to terminated acquisition 0 0
Deferred compensation plan assets 0 0
Total assets measured at fair value 795 2,719
Liabilities:    
Contingent consideration liabilities 0 0
Deferred compensation plan liability 0 0
Total liabilities measured at fair value 0 0
Fair value, Measurements, Recurring | Level 1 | Money market funds (cash equivalents)    
Assets:    
Money market funds (cash equivalents) 688 1,512
Fair value, Measurements, Recurring | Level 1 | Debt securities in government-sponsored entities    
Assets:    
Available-for-sale securities 0 0
Fair value, Measurements, Recurring | Level 1 | Corporate debt securities    
Assets:    
Available-for-sale securities 0 0
Fair value, Measurements, Recurring | Level 1 | U.S. Treasury securities    
Assets:    
Available-for-sale securities 0 831
Fair value, Measurements, Recurring | Level 2    
Assets:    
Marketable equity securities 0 0
Helix contingent value right 0 0
Derivative assets related to terminated acquisition 0 0
Deferred compensation plan assets 60 55
Total assets measured at fair value 60 510
Liabilities:    
Contingent consideration liabilities 0 0
Deferred compensation plan liability 56 51
Total liabilities measured at fair value 56 51
Fair value, Measurements, Recurring | Level 2 | Money market funds (cash equivalents)    
Assets:    
Money market funds (cash equivalents) 0 0
Fair value, Measurements, Recurring | Level 2 | Debt securities in government-sponsored entities    
Assets:    
Available-for-sale securities 0 10
Fair value, Measurements, Recurring | Level 2 | Corporate debt securities    
Assets:    
Available-for-sale securities 0 445
Fair value, Measurements, Recurring | Level 2 | U.S. Treasury securities    
Assets:    
Available-for-sale securities 0 0
Fair value, Measurements, Recurring | Level 3    
Assets:    
Marketable equity securities 0 0
Helix contingent value right 65 35
Derivative assets related to terminated acquisition 0 26
Deferred compensation plan assets 0 0
Total assets measured at fair value 65 61
Liabilities:    
Contingent consideration liabilities 615 0
Deferred compensation plan liability 0 0
Total liabilities measured at fair value 615 0
Fair value, Measurements, Recurring | Level 3 | Money market funds (cash equivalents)    
Assets:    
Money market funds (cash equivalents) 0 0
Fair value, Measurements, Recurring | Level 3 | Debt securities in government-sponsored entities    
Assets:    
Available-for-sale securities 0 0
Fair value, Measurements, Recurring | Level 3 | Corporate debt securities    
Assets:    
Available-for-sale securities 0 0
Fair value, Measurements, Recurring | Level 3 | U.S. Treasury securities    
Assets:    
Available-for-sale securities $ 0 $ 0
v3.22.0.1
Investments and Fair Value Measurements - Changes in Estimated Fair Value of Acquisition Related Contingent Consideration Liabilities (Details)
$ in Millions
3 Months Ended 12 Months Ended
Jan. 02, 2022
USD ($)
Jan. 02, 2022
USD ($)
Fair Value, Assets Measured on Recurring Basis, Unobservable Input Reconciliation [Line Items]    
Measurement period adjustment   $ (5)
GRAIL Inc    
Fair Value, Assets Measured on Recurring Basis, Unobservable Input Reconciliation [Line Items]    
Measurement period adjustment $ (5)  
Change in estimated fair value   7
Business Combination, Contingent Consideration, Liability    
Fair Value, Assets Measured on Recurring Basis, Unobservable Input Reconciliation [Line Items]    
Beginning balance   0
Cash payments 15 (15)
Exchange of GRAIL contingent value rights   (145)
Change in estimated fair value   4
Ending balance $ 615 615
Business Combination, Contingent Consideration, Liability | GRAIL Inc    
Fair Value, Assets Measured on Recurring Basis, Unobservable Input Reconciliation [Line Items]    
Acquisitions   762
Business Combination, Contingent Consideration, Liability | Other Acquisition    
Fair Value, Assets Measured on Recurring Basis, Unobservable Input Reconciliation [Line Items]    
Acquisitions   $ 14
v3.22.0.1
Acquisitions, Goodwill and Intangible Assets - Narrative (Details) - USD ($)
$ / shares in Units, shares in Millions
1 Months Ended 3 Months Ended 5 Months Ended 12 Months Ended
Aug. 18, 2021
Aug. 17, 2021
Dec. 31, 2021
Jan. 02, 2022
Oct. 03, 2021
Jul. 04, 2021
Jan. 02, 2022
Jan. 02, 2022
Jan. 03, 2021
Dec. 29, 2019
Goodwill [Line Items]                    
Change in fair value of contingent consideration liabilities               $ (4,000,000) $ 0 $ 0
Goodwill, purchase accounting adjustments       $ 6,000,000       15,000,000    
Gain on exchange of GRAIL contingent value rights               86,000,000 0 0
Gain on previously held investment in GRAIL               $ 899,000,000 0 0
Share price (in dollars per share)     $ 380.44              
Expected dividend yield               0.00%    
Goodwill impairment           $ 0        
Goodwill       7,113,000,000     $ 7,113,000,000 $ 7,113,000,000 897,000,000 $ 824,000,000
Developed technology                    
Goodwill [Line Items]                    
Weighted-average useful lives (in years)               18 years    
GRAIL Inc                    
Goodwill [Line Items]                    
Change in fair value of contingent consideration liabilities       (5,000,000)       $ (3,000,000)    
Increase (decrease) in previously held investment in GRAIL       (1,000,000)            
Goodwill, purchase accounting adjustments             15,000,000      
Business acquisition, common stock issued (in shares) 9.8                  
Contingent value right, terms 12 years                  
Contingent consideration liabilities     $ 145,000,000 615,000,000     615,000,000 615,000,000    
Contingent value rights exchanged     73.0              
Payment for contingent consideration     $ 57,000,000              
Number of shares issued in exchange for contingent consideration     2.0              
Gain on exchange of GRAIL contingent value rights     $ 86,000,000              
Business combination, consideration transferred for contingent consideration transferred     $ 59,000,000              
Contingent consideration, noncurrent       614,000,000     614,000,000 614,000,000    
Equity ownership percentage 12.00%                  
Equity investment $ 1,100,000,000                  
Gain on previously held investment in GRAIL               899,000,000    
Purchase price related to fair value of equity awards attributable to pre-combination service 69,000,000                  
Share-based payment arrangement, accelerated cost               615,000,000    
Fair value of replacement awards $ 48,000,000                  
Share price (in dollars per share) $ 510.61                  
Risk-free interest rate, minimum 0.17%                  
Risk-free interest rate, maximum 0.28%                  
Expected volatility, minimum 40.00%                  
Expected volatility, maximum 43.00%                  
Expected dividend yield 0.00%                  
Weighted average acquisition-date fair value per share (in dollars per share) $ 424.39                  
Acquisition related costs               156,000,000    
Business combination, continuation payments   $ 35,000,000                
Goodwill $ 6,082,000,000     $ 6,097,000,000     $ 6,097,000,000 6,097,000,000    
GRAIL Inc | Selling, general and administrative                    
Goodwill [Line Items]                    
Business combination, continuation payments               245,000,000 35,000,000  
GRAIL Inc | Minimum                    
Goodwill [Line Items]                    
Expected term 1 year 7 months 6 days                  
GRAIL Inc | Maximum                    
Goodwill [Line Items]                    
Expected term 2 years 2 months 12 days                  
GRAIL Inc | Payment Rights Of One Billion Each Twelve Years                    
Goodwill [Line Items]                    
Contingent payment rights, first percentage 2.50%                  
Business acquisition, contingent value rights, revenue threshold $ 1,000,000,000                  
GRAIL Inc | Payment Rights Of Above One Billion Each Twelve Years                    
Goodwill [Line Items]                    
Business acquisition, contingent value rights, revenue threshold $ 1,000,000,000                  
Contingent payment rights, second percentage 9.00%                  
Series of Individually Immaterial Business Acquisitions                    
Goodwill [Line Items]                    
Change in fair value of contingent consideration liabilities               $ 1,000,000    
Series of Individually Immaterial Business Acquisitions | Developed technology                    
Goodwill [Line Items]                    
Value of intangible assets acquired         $ 28,000,000       $ 26,000,000  
Weighted-average useful lives (in years)         10 years       10 years  
Series of Individually Immaterial Business Acquisitions | In-process research and development (IPR&D)                    
Goodwill [Line Items]                    
Indefinite-lived intangible assets acquired           $ 35,000,000        
v3.22.0.1
Acquisitions, Goodwill and Intangible Assets - Summary of Total Purchase Price (Details) - GRAIL Inc
$ in Millions
Aug. 18, 2021
USD ($)
Goodwill [Line Items]  
Cash $ 2,862
Fair value of common stock issued 4,975
Fair value of contingent consideration 757
Fair value of previously held investment 1,149
Settlement of preexisting relationships 2
Total purchase price $ 9,745
v3.22.0.1
Acquisitions, Goodwill and Intangible Assets - Preliminary Fair Value of Assets Acquired and Liabilities Assumed (Details) - USD ($)
$ in Millions
3 Months Ended 5 Months Ended 12 Months Ended
Jan. 02, 2022
Jan. 02, 2022
Jan. 02, 2022
Aug. 18, 2021
Jan. 03, 2021
Dec. 29, 2019
Finite-Lived Intangible Assets [Line Items]            
Goodwill $ 7,113 $ 7,113 $ 7,113   $ 897 $ 824
Measurement period adjustments, goodwill 6   15      
GRAIL Inc            
Finite-Lived Intangible Assets [Line Items]            
Cash and cash equivalents 571 571 571 $ 571    
Property and equipment 89 89 89 89    
Operating lease right-of-use assets 121 121 121 121    
Goodwill 6,097 6,097 6,097 6,082    
Measurement period adjustments, goodwill   15        
Intangible assets 3,120 3,120 3,120 3,180    
Measurement period adjustments, intangibles   (60)        
Other current and noncurrent assets 35 35 35 35    
Deferred tax liability (42) (42) (42) (82)    
Measurement period adjustments, deferred tax liability   40        
Long-term lease liabilities (97) (97) (97) (97)    
Other current and noncurrent liabilities (149) (149) (149) (148)    
Measurement period adjustments, other current and noncurrent liabilities   (1)        
Total net assets acquired $ 9,745 9,745 $ 9,745 $ 9,751    
Measurement period adjustments, Total net assets acquired   $ (6)        
v3.22.0.1
Acquisitions, Goodwill and Intangible Assets - Summary of Amount Assigned to Identifiable Intangible Assets (Details) - USD ($)
$ in Millions
12 Months Ended
Jan. 02, 2022
Aug. 18, 2021
Developed technology    
Indefinite-lived Intangible Assets [Line Items]    
Useful life (in years) 18 years  
Trade name    
Indefinite-lived Intangible Assets [Line Items]    
Useful life (in years) 9 years  
GRAIL Inc    
Indefinite-lived Intangible Assets [Line Items]    
Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Intangible Assets, Other than Goodwill, Total $ 3,120 $ 3,180
GRAIL Inc | In-process research and development (IPR&D)    
Indefinite-lived Intangible Assets [Line Items]    
Indefinite lived intangible assets acquired 670  
GRAIL Inc | Developed technology    
Indefinite-lived Intangible Assets [Line Items]    
Finite-lived intangible assets acquired 2,410  
GRAIL Inc | Trade name    
Indefinite-lived Intangible Assets [Line Items]    
Finite-lived intangible assets acquired $ 40  
v3.22.0.1
Acquisitions, Goodwill and Intangible Assets - Summary of Pro Forma Information (Details) - GRAIL Inc - USD ($)
$ in Millions
12 Months Ended
Jan. 02, 2022
Jan. 03, 2021
Indefinite-lived Intangible Assets [Line Items]    
Revenue $ 4,528 $ 3,239
Net income $ 661 $ 351
v3.22.0.1
Acquisitions, Goodwill and Intangible Assets - Summary of Changes in Goodwill (Details) - USD ($)
$ in Millions
3 Months Ended 12 Months Ended
Jan. 02, 2022
Jan. 02, 2022
Dec. 29, 2019
Goodwill [Roll Forward]      
Balance at beginning of period   $ 897  
Acquisitions   6,201 $ 73
Measurement period adjustments $ 6 15  
Balance at end of period $ 7,113 $ 7,113 $ 824
v3.22.0.1
Acquisitions, Goodwill and Intangible Assets - Summary of Identifiable Intangible Assets (Details) - USD ($)
$ in Millions
Jan. 02, 2022
Jan. 03, 2021
Finite-Lived Intangible Assets [Line Items]    
Gross Carrying Amount $ 2,974 $ 496
Accumulated Amortization (429) (354)
Total intangible assets, net 2,545 142
Intangible Assets, Net (Excluding Goodwill) [Abstract]    
Gross Carrying Amount 3,679 496
Accumulated Amortization 429 354
Intangible Assets, Net 3,250 142
In-process research and development (IPR&D)    
Indefinite-lived Intangible Assets [Line Items]    
Indefinite-lived Intangible Assets 705 0
Developed technologies    
Finite-Lived Intangible Assets [Line Items]    
Gross Carrying Amount 2,790 352
Accumulated Amortization (291) (221)
Total intangible assets, net 2,499 131
Intangible Assets, Net (Excluding Goodwill) [Abstract]    
Accumulated Amortization 291 221
Licensed technologies    
Finite-Lived Intangible Assets [Line Items]    
Gross Carrying Amount 95 95
Accumulated Amortization (92) (91)
Total intangible assets, net 3 4
Intangible Assets, Net (Excluding Goodwill) [Abstract]    
Accumulated Amortization 92 91
Trade name    
Finite-Lived Intangible Assets [Line Items]    
Gross Carrying Amount 44 4
Accumulated Amortization (6) (4)
Total intangible assets, net 38 0
Intangible Assets, Net (Excluding Goodwill) [Abstract]    
Accumulated Amortization 6 4
Customer relationships    
Finite-Lived Intangible Assets [Line Items]    
Gross Carrying Amount 31 31
Accumulated Amortization (28) (27)
Total intangible assets, net 3 4
Intangible Assets, Net (Excluding Goodwill) [Abstract]    
Accumulated Amortization 28 27
License agreements    
Finite-Lived Intangible Assets [Line Items]    
Gross Carrying Amount 14 14
Accumulated Amortization (12) (11)
Total intangible assets, net 2 3
Intangible Assets, Net (Excluding Goodwill) [Abstract]    
Accumulated Amortization $ 12 $ 11
v3.22.0.1
Acquisitions, Goodwill and Intangible Assets - Summary of Estimated Annual Amortization of Intangible Assets (Details) - USD ($)
$ in Millions
Jan. 02, 2022
Jan. 03, 2021
Estimated Annual Amortization    
2022 $ 165  
2023 164  
2024 162  
2025 162  
2026 151  
Thereafter 1,741  
Total intangible assets, net $ 2,545 $ 142
v3.22.0.1
Debt and Other Commitments - Summary of Debt Obligations (Details) - USD ($)
12 Months Ended
Jan. 02, 2022
Jan. 03, 2021
Dec. 29, 2019
Mar. 23, 2021
Aug. 31, 2018
Jun. 30, 2014
Term Notes            
Debt Instrument [Line Items]            
Unamortized discounts and debt issuance costs $ (7,000,000)          
Net carrying amount of debt 993,000,000          
Less: current portion 0          
Long-term debt, non-current 993,000,000          
Interest expense recognized 14,000,000          
Term Notes | Level 2            
Debt Instrument [Line Items]            
Fair value of term notes outstanding (Level 2) 996,000,000          
Term Notes | Term Notes Due 2031            
Debt Instrument [Line Items]            
Principal amount of notes outstanding 500,000,000     $ 500,000,000    
Term Notes | Term Notes Due 2023            
Debt Instrument [Line Items]            
Principal amount of notes outstanding 500,000,000     $ 500,000,000    
Convertible Senior Notes            
Debt Instrument [Line Items]            
Unamortized discount of liability component of convertible senior notes (48,000,000) $ (83,000,000)        
Net carrying amount of debt 702,000,000 1,184,000,000        
Less: current portion 0 (511,000,000)        
Long-term debt, non-current 702,000,000 673,000,000        
Carrying value of equity component of convertible senior notes, net of debt issuance costs $ 126,000,000 $ 213,000,000        
Weighted-average remaining amortization period of discount on the liability component of convertible senior notes 1 year 7 months 6 days 2 years 4 months 24 days        
Interest expense recognized $ 36,000,000 $ 46,000,000 $ 51,000,000      
Convertible Senior Notes | Level 2            
Debt Instrument [Line Items]            
Fair value of convertible senior notes outstanding (Level 2) 854,000,000 1,595,000,000        
Convertible Senior Notes | 2023 Notes            
Debt Instrument [Line Items]            
Principal amount of notes outstanding 750,000,000 750,000,000     $ 750,000,000  
Convertible Senior Notes | 2021 Notes            
Debt Instrument [Line Items]            
Principal amount of notes outstanding $ 0 $ 517,000,000       $ 517,000,000
v3.22.0.1
Debt and Other Commitments - Narrative (Details)
1 Months Ended 12 Months Ended
Mar. 23, 2021
USD ($)
Mar. 08, 2021
USD ($)
Sep. 20, 2020
USD ($)
Aug. 31, 2018
USD ($)
day
$ / shares
Jan. 02, 2022
USD ($)
renewal
Jan. 03, 2021
USD ($)
Dec. 29, 2019
USD ($)
Aug. 21, 2018
Jun. 30, 2014
USD ($)
Debt Instrument [Line Items]                  
Additional paid in capital, net of tax         $ 8,938,000,000 $ 3,815,000,000      
Bridge facility                  
Debt Instrument [Line Items]                  
Debt instrument term     364 days            
Term Notes                  
Debt Instrument [Line Items]                  
Net proceeds from issuance, after deducting offering expenses payable $ 992,000,000                
Redemption price, percentage         100.00%        
Interest expense recognized         $ 14,000,000        
Term Notes | Term Notes Due 2023                  
Debt Instrument [Line Items]                  
Principal amount $ 500,000,000       500,000,000        
Interest rate on convertible senior notes 0.55%                
Term Notes | Term Notes Due 2031                  
Debt Instrument [Line Items]                  
Principal amount $ 500,000,000       $ 500,000,000        
Interest rate on convertible senior notes 2.55%                
Line of Credit | The Credit Agreement                  
Debt Instrument [Line Items]                  
Debt instrument term, number of renewal | renewal         2        
Debt instrument, renewal term         1 year        
Borrowings outstanding         $ 0        
Line of Credit | Revolving Credit Facility | The Credit Agreement                  
Debt Instrument [Line Items]                  
Debt instrument term   5 years              
Maximum borrowing capacity   $ 750,000,000              
Line of Credit | Swingline Borrowings | The Credit Agreement                  
Debt Instrument [Line Items]                  
Maximum borrowing capacity   40,000,000              
Line of Credit | Letter of Credit | The Credit Agreement                  
Debt Instrument [Line Items]                  
Maximum borrowing capacity   50,000,000              
Unsecured Debt | The Credit Agreement                  
Debt Instrument [Line Items]                  
Debt instrument, face amount, optional increase in additional borrowings   $ 250,000,000              
Debt instrument, covenant, minimum debt to EBITDA ratio         3.50        
Debt instrument, covenant, minimum debt to EBITDA ratio upon consummation of acquisition         4.00        
Unsecured Debt | Bridge facility                  
Debt Instrument [Line Items]                  
Principal amount     $ 1,000,000,000            
Convertible Senior Notes                  
Debt Instrument [Line Items]                  
Interest expense recognized         $ 36,000,000 46,000,000 $ 51,000,000    
Carrying value of equity component of convertible senior notes, net of debt issuance costs         126,000,000 213,000,000      
Convertible Senior Notes | 2023 Notes                  
Debt Instrument [Line Items]                  
Principal amount       $ 750,000,000 750,000,000 750,000,000      
Interest rate on convertible senior notes               0.00%  
Net proceeds from issuance, after deducting offering expenses payable       $ 735,000,000          
Redemption price, percentage       100.00%          
Conversion price (in dollars per share) | $ / shares       $ 457.77          
Threshold common stock trading days | day       20          
Threshold consecutive common stock trading days | day       30          
Threshold percentage of common stock price trigger       130.00%          
Threshold note trading days | day       5          
Threshold consecutive note trading days | day       10          
Threshold percentage of note price trigger       98.00%          
Observation period       20 days          
Effective conversion rate divided period       20 days          
Convertible stock price trigger (in dollars per share) | $ / shares       $ 595.10          
Effective interest rate used to measure fair value of convertible senior note       3.70%          
Debt, fair value       $ 624,000,000          
Additional paid in capital, before tax       126,000,000          
Additional paid in capital, net of tax       $ 93,000,000          
Convertible Senior Notes | 2021 Notes                  
Debt Instrument [Line Items]                  
Principal amount         $ 0 $ 517,000,000     $ 517,000,000
Interest rate on convertible senior notes                 0.50%
Effective interest rate used to measure fair value of convertible senior note                 3.50%
v3.22.0.1
Debt and Other Commitments - Summary of Debt Conversions (Details) - 2021 Notes
shares in Millions, $ in Millions
12 Months Ended
Jan. 02, 2022
USD ($)
shares
Short-term Debt [Line Items]  
Cash paid for principal of notes converted $ 517
Conversion value over principal amount, paid in shares of common stock $ 313
Number of shares of common stock issued upon conversion (in shares) | shares 0.7
Loss on extinguishment of debt $ 1
v3.22.0.1
Debt and Other Commitments - Summary of Maturities of Operating Lease Liabilities (Details) - USD ($)
$ in Millions
Jan. 02, 2022
Jan. 03, 2021
Debt Disclosure [Abstract]    
2022 $ 103  
2023 101  
2024 112  
2025 105  
2026 103  
Thereafter 517  
Total remaining lease payments 1,041  
Less: imputed interest (196)  
Total operating lease liabilities 845  
Less: current portion (71) $ (51)
Long-term operating lease liabilities $ 774 $ 671
Weighted-average remaining lease term 9 years 10 months 24 days  
Weighted-average discount rate 4.10%  
Lease payments for leases not yet commenced $ 8  
v3.22.0.1
Debt and Other Commitments - Summary of Lease Costs (Details) - USD ($)
$ in Millions
12 Months Ended
Jan. 02, 2022
Jan. 03, 2021
Dec. 29, 2019
Debt Disclosure [Abstract]      
Operating lease costs $ 99 $ 84 $ 84
Sublease income (16) (11) (12)
Total lease costs $ 83 $ 73 $ 72
v3.22.0.1
Stockholders' Equity - Narrative (Details)
shares in Millions
Jan. 02, 2022
shares
2015 Stock Plan  
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]  
Shares available for issuance 3.4
v3.22.0.1
Stockholders' Equity - Narrative - Restricted Stock (Details)
1 Months Ended 12 Months Ended
Feb. 28, 2021
Aug. 31, 2020
Jan. 02, 2022
RSU      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]      
Share based compensation vesting performance period     4 years
PSU      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]      
Share based compensation vesting performance period 3 years 3 years 3 years
v3.22.0.1
Stockholders' Equity - Summary of Restricted Stock Activity and Related Information (Details) - $ / shares
shares in Thousands
12 Months Ended
Jan. 02, 2022
Jan. 03, 2021
Dec. 29, 2019
RSU      
Stock Units      
Outstanding at period start (in shares) 1,721 1,700 1,840
Awarded (in shares) 259 878 698
Vested (in shares) (606) (655) (694)
Cancelled (in shares) (244) (202) (144)
Outstanding at period end (in shares) 1,130 1,721 1,700
Weighted-Average Grant- Date Fair Value per Share      
Outstanding at period start (in dollars per share) $ 313.35 $ 271.49 $ 227.00
Awarded (in dollars per share) 438.46 329.83 313.70
Vested (in dollars per share) 303.08 239.19 205.51
Cancelled (in dollars per share) 321.93 273.13 225.48
Outstanding at period end (in dollars per share) $ 345.66 $ 313.35 $ 271.49
RSU | GRAIL Inc      
Stock Units      
Awarded (in shares) 59    
PSU      
Stock Units      
Outstanding at period start (in shares) 0 271 660
Awarded (in shares) 456 (78) (41)
Vested (in shares) (72) (117) (283)
Cancelled (in shares) (56) (76) (65)
Outstanding at period end (in shares) 328 0 271
Weighted-Average Grant- Date Fair Value per Share      
Outstanding at period start (in dollars per share) $ 0 $ 258.66 $ 196.99
Awarded (in dollars per share) 471.63 344.22 254.52
Vested (in dollars per share) 492.55 400.74 133.11
Cancelled (in dollars per share) 475.38 266.63 181.79
Outstanding at period end (in dollars per share) $ 466.42 $ 0 $ 258.66
v3.22.0.1
Stockholders' Equity - Summary of Pre-tax Intrinsic Values and Total Fair Value of Vested Restricted Stock (Details) - USD ($)
$ in Millions
12 Months Ended
Jan. 02, 2022
Jan. 03, 2021
Dec. 29, 2019
RSU      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]      
Pre-tax intrinsic value of outstanding restricted stock: $ 430 $ 637 $ 565
Fair value of restricted stock vested: 247 206 210
PSU      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]      
Pre-tax intrinsic value of outstanding restricted stock: 125 0 90
Fair value of restricted stock vested: $ 35 $ 47 $ 38
v3.22.0.1
Stockholders' Equity - Summary of Stock Option Activity Under all Stock Option Plans (Details) - $ / shares
shares in Thousands
12 Months Ended
Jan. 02, 2022
Jan. 03, 2021
Dec. 29, 2019
Options      
Options and Performance Stock Options      
Outstanding at period start (in shares) 10 58 192
Granted (in shares) 0    
Exercised (in shares) (2) (48) (134)
Cancelled (in shares) 0    
Outstanding at period end (in shares) 8 10 58
Weighted-Average Exercise Price      
Outstanding at period start (in dollars per share) $ 59.11 $ 56.65 $ 54.52
Granted (in dollars per share) 0    
Exercised (in dollars per share) 20.06 56.16 53.61
Cancelled (in dollars per share) 0    
Outstanding at period end (in dollars per share) $ 66.42 $ 59.11 $ 56.65
Performance stock options      
Options and Performance Stock Options      
Outstanding at period start (in shares) 0 0 0
Granted (in shares) 48    
Exercised (in shares) (21) 0 0
Cancelled (in shares) (10)    
Outstanding at period end (in shares) 17 0 0
Weighted-Average Exercise Price      
Outstanding at period start (in dollars per share) $ 0 $ 0 $ 0
Granted (in dollars per share) 86.73    
Exercised (in dollars per share) 86.72 0 0
Cancelled (in dollars per share) 89.63    
Outstanding at period end (in dollars per share) $ 85.54 $ 0 $ 0
v3.22.0.1
Stockholders' Equity - Narrative - Stock Options (Details) - USD ($)
12 Months Ended
Jan. 02, 2022
Jan. 03, 2021
Dec. 29, 2019
Dec. 31, 2021
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]        
Aggregate intrinsic value of options outstanding $ 3,000,000      
Aggregate intrinsic value of options exercisable 3,000,000      
Share price (in dollars per share)       $ 380.44
Total intrinsic value of options exercised $ 1,000,000 $ 14,000,000 $ 34,000,000  
Weighted average remaining life in years of options exercisable 1 year 4 months 24 days      
Performance stock options        
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]        
Aggregate intrinsic value of options outstanding $ 6,000,000      
Aggregate intrinsic value of options exercisable 0      
Total intrinsic value of options exercised $ 6,000,000      
Weighted average remaining life in years of options exercisable 10 years      
v3.22.0.1
Stockholders' Equity - Narrative - Liability-Classified Award (Details) - USD ($)
12 Months Ended
Jan. 02, 2022
Jan. 03, 2021
Dec. 29, 2019
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]      
Unrecognized compensation cost $ 442,000,000    
Weighted-average period of unrecognized compensation cost 2 years 1 month 6 days    
Share-based compensation expense $ 941,000,000 $ 194,000,000 $ 194,000,000
Liability-Based Awards      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]      
Award expiration period 4 years    
Share based compensation vesting performance period 4 years    
Cash incentive award, target award amount $ 218,000,000    
Award forfeited value 42,000,000    
Share-based payment arrangement, liability-classified award 11,000,000    
Unrecognized compensation cost $ 173,000,000    
Weighted-average period of unrecognized compensation cost 3 years 8 months 12 days    
Aggregated potential value $ 78,000,000    
Share-based compensation expense $ 0    
v3.22.0.1
Stockholders' Equity - Narrative - Employee Stock Purchase Plan (Details) - ESPP - Employee Stock - shares
shares in Millions
12 Months Ended
Jan. 02, 2022
Jan. 03, 2021
Dec. 29, 2019
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]      
ESPP number of shares reserved for issuance (in shares) 15.5    
Specified percentage of the fair market value of the common stock on the first or last day of the offering period whichever is lower at which stock is purchased 85.00%    
Total shares issued under the ESPP (in shares) 0.2 0.2 0.2
Shares available for issuance (in shares) 13.1 13.3  
v3.22.0.1
Stockholders' Equity - Narrative - Share Repurchases (Details) - USD ($)
shares in Millions
12 Months Ended
Jan. 02, 2022
Jan. 03, 2021
Dec. 29, 2019
Feb. 05, 2020
Class of Stock [Line Items]        
Common stock repurchases $ 0 $ 736,000,000 $ 324,000,000  
Common Stock        
Class of Stock [Line Items]        
Repurchase of common shares (in shares) 0.0 2.3 1.1  
Common stock repurchases   $ 735,000,000 $ 324,000,000  
Dollar amount remaining in authorized stock repurchase program $ 15,000,000      
Stock repurchase program authorized amount       $ 750,000,000
v3.22.0.1
Stockholders' Equity - Summary of Share-based Compensation Expense for all Stock Awards (Details) - USD ($)
$ in Millions
12 Months Ended
Jan. 02, 2022
Jan. 03, 2021
Dec. 29, 2019
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]      
Share-based compensation expense, before taxes $ 941 $ 194 $ 194
Related income tax benefits (64) (43) (41)
Share-based compensation expense, net of taxes 877 151 153
Cost of product revenue      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]      
Share-based compensation expense, before taxes 23 21 19
Cost of service and other revenue      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]      
Share-based compensation expense, before taxes 4 4 4
Research and development      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]      
Share-based compensation expense, before taxes 276 74 66
Selling, general and administrative      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]      
Share-based compensation expense, before taxes $ 638 $ 95 $ 105
v3.22.0.1
Stockholders' Equity - Narrative- Share-based Compensation (Details)
$ in Millions
1 Months Ended 12 Months Ended
Feb. 28, 2021
USD ($)
employee
Aug. 31, 2020
employee
Jan. 02, 2022
USD ($)
Jan. 03, 2021
USD ($)
Dec. 29, 2019
USD ($)
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Share-based compensation expense, before taxes     $ 941 $ 194 $ 194
Research and development          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Share-based compensation expense, before taxes     276 74 66
Selling, general and administrative          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Share-based compensation expense, before taxes     638 95 $ 105
GRAIL Inc          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Share-based payment arrangement, accelerated cost     615    
Replacement Awards | GRAIL Inc          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Share-based payment arrangement, accelerated cost     615    
Share-based compensation expense, before taxes     24    
Replacement Awards | GRAIL Inc | Research and development          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Share-based payment arrangement, accelerated cost     167    
Replacement Awards | GRAIL Inc | Selling, general and administrative          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Share-based payment arrangement, accelerated cost     $ 448    
PSU          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Share based compensation vesting performance period 3 years 3 years 3 years    
Number of employees effected by modification | employee   49      
Incremental share-based compensation cost       $ 47  
Performance Shares, Granted In 2019          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Number of employees effected by modification | employee 52        
Incremental share-based compensation cost $ 41        
Performance Shares, Granted In 2020          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Number of employees effected by modification | employee 72        
Incremental share-based compensation cost $ 65        
v3.22.0.1
Stockholders' Equity - Summary of Assumptions used to Estimate the Weighted-Average Fair Value Per Share for Stock Purchase under the Employee Stock Purchase Plan (Details) - USD ($)
$ / shares in Units, $ in Millions
12 Months Ended
Jan. 02, 2022
Jan. 03, 2021
Dec. 29, 2019
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]      
Expected dividends 0.00%    
Unrecognized compensation cost related to stock options, restricted stock, and ESPP shares granted to date $ 442    
Weighted-average period of unrecognized compensation cost related to stock options, restricted stock, and ESPP shares granted to date 2 years 1 month 6 days    
Employee Stock      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]      
Risk-free interest rate, minimum 0.06% 0.11% 188.00%
Risk-free interest rate, maximum 0.12% 2.04% 256.00%
Expected volatility, minimum 37.00% 30.00% 30.00%
Expected volatility, maximum 47.00% 45.00% 38.00%
Expected dividends 0.00% 0.00% 0.00%
Weighted-average grant-date fair value per share (in dollars per share) $ 134.47 $ 75.57 $ 75.47
Employee Stock | Minimum      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]      
Expected term 6 months 6 months 6 months
Employee Stock | Maximum      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]      
Expected term 1 year 1 year 1 year
v3.22.0.1
Supplemental Balance Sheet and Statement of Income Details - Summary of Accounts Receivable (Details) - USD ($)
$ in Millions
Jan. 02, 2022
Jan. 03, 2021
Organization, Consolidation and Presentation of Financial Statements [Abstract]    
Trade accounts receivable, gross $ 651 $ 491
Allowance for credit losses (3) (4)
Total accounts receivable, net $ 648 $ 487
v3.22.0.1
Supplemental Balance Sheet and Statement of Income Details - Summary of Inventory (Details) - USD ($)
$ in Millions
Jan. 02, 2022
Jan. 03, 2021
Organization, Consolidation and Presentation of Financial Statements [Abstract]    
Raw materials $ 92 $ 106
Work in process 312 244
Finished goods 27 22
Total inventory $ 431 $ 372
v3.22.0.1
Supplemental Balance Sheet and Statement of Income Details - Summary of Property and Equipment (Details) - USD ($)
$ in Millions
Jan. 02, 2022
Jan. 03, 2021
Property, Plant and Equipment [Line Items]    
Total property and equipment, gross $ 1,820 $ 1,600
Accumulated depreciation (796) (678)
Total property and equipment, net 1,024 922
Leasehold improvements    
Property, Plant and Equipment [Line Items]    
Total property and equipment, gross 724 645
Machinery and equipment    
Property, Plant and Equipment [Line Items]    
Total property and equipment, gross 513 461
Computer hardware and software    
Property, Plant and Equipment [Line Items]    
Total property and equipment, gross 377 305
Furniture and fixtures    
Property, Plant and Equipment [Line Items]    
Total property and equipment, gross 49 46
Buildings    
Property, Plant and Equipment [Line Items]    
Total property and equipment, gross 44 44
Construction in progress    
Property, Plant and Equipment [Line Items]    
Total property and equipment, gross $ 113 $ 99
v3.22.0.1
Supplemental Balance Sheet and Statement of Income Details - Narrative - Property and Equipment (Details) - USD ($)
$ in Millions
12 Months Ended
Jan. 02, 2022
Jan. 03, 2021
Dec. 29, 2019
Organization, Consolidation and Presentation of Financial Statements [Abstract]      
Non-cash expenditures included in property and equipment, net $ 17 $ 22 $ 20
v3.22.0.1
Supplemental Balance Sheet and Statement of Income Details - Summary of Accrued Liabilities (Details) - USD ($)
$ in Millions
Jan. 02, 2022
Jan. 03, 2021
Organization, Consolidation and Presentation of Financial Statements [Abstract]    
Accrued compensation expenses $ 252 $ 153
Contract liabilities, current portion 234 186
Accrued taxes payable 98 68
Operating lease liabilities, current portion 71 51
Contingent consideration liabilities, current portion 1 0
Other, including warranties 105 83
Total accrued liabilities $ 761 $ 541
Operating Lease, Liability, Current, Statement of Financial Position [Extensible List] Total accrued liabilities Total accrued liabilities
v3.22.0.1
Supplemental Balance Sheet and Statement of Income Details - Summary of Changes in Reserve for Product Warranties (Details) - USD ($)
$ in Millions
12 Months Ended
Jan. 02, 2022
Jan. 03, 2021
Dec. 29, 2019
Movement in Standard and Extended Product Warranty Accrual, Increase (Decrease) [Roll Forward]      
Balance as of beginning of period $ 13 $ 14 $ 19
Additions charged to cost of product revenue 33 20 20
Repairs and replacements (24) (21) (25)
Balance as of end of period $ 22 $ 13 $ 14
v3.22.0.1
Supplemental Balance Sheet and Statement of Income Details - Other Income, Net (Details) - USD ($)
$ in Millions
12 Months Ended
Jan. 02, 2022
Jan. 03, 2021
Dec. 29, 2019
Organization, Consolidation and Presentation of Financial Statements [Abstract]      
Gain on previously held investment in GRAIL $ 899 $ 0 $ 0
Gain on exchange of GRAIL contingent value rights 86 0 0
Gain (loss) on Helix contingent value right 30 7 (1)
(Gain) loss on derivative assets related to terminated acquisition 26 (25) 0
Gains on deconsolidations 0 0 54
Other 9 11 (5)
Other income, net 1,068 284 110
Gains on strategic investments, net $ 18 $ 291 $ 62
v3.22.0.1
Legal Proceedings (Details) - USD ($)
$ in Millions
Nov. 30, 2021
May 12, 2021
Apr. 12, 2021
Commitments and Contingencies Disclosure [Abstract]      
Loss contingency, damages sought, value   $ 225 $ 54
Loss contingency, royalty on sales of accused products, percentage   5.50% 3.60%
Amount awarded from settlement $ 8    
v3.22.0.1
Income Taxes - Summary of Income (Loss) Before Income Taxes by Region (Details) - USD ($)
$ in Millions
12 Months Ended
Jan. 02, 2022
Jan. 03, 2021
Dec. 29, 2019
Income Tax Disclosure [Abstract]      
United States $ (115) $ 313 $ 242
Foreign 999 543 876
Income before income taxes $ 884 $ 856 $ 1,118
v3.22.0.1
Income Taxes - Summary of Provision for Income Taxes (Details) - USD ($)
$ in Millions
12 Months Ended
Jan. 02, 2022
Jan. 03, 2021
Dec. 29, 2019
Current:      
Federal $ 54 $ 25 $ 32
State 37 13 7
Foreign 107 45 84
Total current provision 198 83 123
Deferred:      
Federal (50) 30 1
State (23) 94 (1)
Foreign (3) (7) 5
Total deferred (benefit) expense (76) 117 5
Total tax provision $ 122 $ 200 $ 128
v3.22.0.1
Income Taxes - Summary of Reconciliation of Provision for Income Taxes to Amount Computed by Applying the Federal Statutory Rate (Details) - USD ($)
$ in Millions
12 Months Ended
Jan. 02, 2022
Jan. 03, 2021
Dec. 29, 2019
Income Tax Disclosure [Abstract]      
Tax at federal statutory rate $ 186 $ 180 $ 235
State, net of federal benefit 13 19 18
Research and other credits (23) (19) (37)
Change in valuation allowance 33 69 (2)
Impact of foreign operations (80) (47) (57)
Impact of foreign derived intangible income (FDII) deduction (12) (11) (4)
Cost sharing adjustment 0 28 0
Investments in consolidated variable interest entities 0 (2) (5)
Stock compensation (10) (18) (20)
Officer compensation 13 7 5
Impact of acquisition related items (16) 0 0
Other 18 (6) (5)
Total tax provision $ 122 $ 200 $ 128
v3.22.0.1
Income Taxes - Narrative (Details) - USD ($)
$ / shares in Units, $ in Millions
12 Months Ended
Jan. 02, 2022
Jan. 03, 2021
Dec. 29, 2019
Tax Credit Carryforward [Line Items]      
Tax expense related to the finalization of court case   $ 28.0  
Valuation allowance on deferred tax assets $ 134.0 81.0  
Deferred tax liability for undistributed foreign earnings 11.5    
Uncertain tax positions that would reduce annual effective tax rate, if recognized 111.0 68.0  
Potential interest penalties on uncertain tax positions 1.0 (1.0) $ (3.0)
Liability recorded for potential interest and penalties 7.0 6.0  
Tax Year 2017      
Tax Credit Carryforward [Line Items]      
Undistributed earnings of foreign subsidiaries 1,067.0    
State      
Tax Credit Carryforward [Line Items]      
Net operating loss carryforwards 1,290.0    
Tax credit carryforwards 165.0    
IRS | Federal      
Tax Credit Carryforward [Line Items]      
Net operating loss carryforwards 1,873.0    
Tax credit carryforwards 50.0    
Singapore | Foreign      
Tax Credit Carryforward [Line Items]      
Decrease to the provision for income taxes $ 82.0 $ 30.0 $ 33.0
Increase to net income per diluted share (in dollars per share) $ 0.55 $ 0.20 $ 0.22
Goodwill      
Tax Credit Carryforward [Line Items]      
Valuation allowance on deferred tax assets $ 20.0    
v3.22.0.1
Income Taxes - Summary of Significant Components of Deferred Tax Assets and Liabilities (Details) - USD ($)
$ in Millions
Jan. 02, 2022
Jan. 03, 2021
Deferred tax assets:    
Net operating losses $ 513 $ 26
Tax credits 128 70
Other accruals and reserves 39 21
Stock compensation 23 17
Other amortization 225 17
Operating lease liabilities 173 156
Other 36 53
Total gross deferred tax assets 1,137 360
Valuation allowance on deferred tax assets (134) (81)
Total deferred tax assets 1,003 279
Deferred tax liabilities:    
Purchased intangible amortization (828) (27)
Convertible debt (11) (20)
Property and equipment (21) (34)
Operating lease right-of-use assets (129) (108)
Investments (29) (137)
Other (12) (6)
Total deferred tax liabilities (1,030) (332)
Deferred tax liabilities, net $ 27 $ 53
v3.22.0.1
Income Taxes - Summary of the Gross Amount of Uncertain Tax Positions (Details) - USD ($)
$ in Millions
12 Months Ended
Jan. 02, 2022
Jan. 03, 2021
Dec. 29, 2019
Reconciliation of Unrecognized Tax Benefits, Excluding Amounts Pertaining to Examined Tax Returns [Roll Forward]      
Balance at beginning of year $ 80 $ 79 $ 88
Increases related to prior year tax positions 19 2 1
Decreases related to prior year tax positions (1) 0 0
Increases related to current year tax positions 39 12 12
Decreases related to lapse of statute of limitations (6) (13) (22)
Balance at end of year $ 131 $ 80 $ 79
v3.22.0.1
Employee Benefit Plans (Details) - USD ($)
$ in Millions
12 Months Ended
Jan. 02, 2022
Jan. 03, 2021
Dec. 29, 2019
Deferred Compensation Arrangement with Individual, Postretirement Benefits [Line Items]      
Matching contributions $ 26 $ 22 $ 20
Deferred Compensation Plan      
Deferred Compensation Arrangement with Individual, Postretirement Benefits [Line Items]      
Employer contribution vesting percent upon the occurrence of participant's disability, death or retirement or change in control of the Company 100.00%    
Deferred compensation plan assets $ 60 55  
Deferred compensation liability $ 56 $ 51  
Deferred Compensation Plan | Senior Level Employee      
Deferred Compensation Arrangement with Individual, Postretirement Benefits [Line Items]      
Percent of base salary available for contribution to the deferred compensation plan 60.00%    
Percent of all other forms of compensation available for contribution to the deferred compensation plan 100.00%    
Deferred Compensation Plan | Director      
Deferred Compensation Arrangement with Individual, Postretirement Benefits [Line Items]      
Percent of all other forms of compensation available for contribution to the deferred compensation plan 100.00%    
v3.22.0.1
Segments and Geographic Data - Narrative (Details)
12 Months Ended
Jan. 02, 2022
segment
Segment Reporting [Abstract]  
Number of reportable segment 2
v3.22.0.1
Segments and Geographic Data - Summary of Operating Performance and Assets by Segment (Details) - USD ($)
$ in Millions
12 Months Ended
Jan. 02, 2022
Jan. 03, 2021
Dec. 29, 2019
Segment Reporting Information [Line Items]      
Consolidated revenue $ 4,526 $ 3,239 $ 3,543
Consolidated depreciation and amortization 251 187 188
Consolidated (loss) income from operations (123) 580 985
Consolidated total assets 15,217 7,585 7,316
Consolidated capital expenditures 208 189 209
Core Illumina      
Segment Reporting Information [Line Items]      
Consolidated capital expenditures 201 189 209
GRAIL      
Segment Reporting Information [Line Items]      
Consolidated capital expenditures 8 0 0
Operating Segments | Core Illumina      
Segment Reporting Information [Line Items]      
Consolidated revenue 4,519 3,239 3,543
Consolidated depreciation and amortization 200 187 186
Consolidated (loss) income from operations 808 580 1,008
Consolidated total assets 5,571 7,585 7,316
Operating Segments | GRAIL      
Segment Reporting Information [Line Items]      
Consolidated revenue 12 0 0
Consolidated depreciation and amortization 51 0 0
Consolidated (loss) income from operations (931) 0 0
Consolidated total assets 9,649 0 0
Operating Segments | Helix      
Segment Reporting Information [Line Items]      
Consolidated revenue 0 0 1
Consolidated depreciation and amortization 0 0 3
Consolidated (loss) income from operations 0 0 (24)
Consolidated total assets 0 0 0
Eliminations      
Segment Reporting Information [Line Items]      
Consolidated revenue (5) 0 (1)
Consolidated depreciation and amortization 0 0 (1)
Consolidated (loss) income from operations 0 0 1
Consolidated total assets (3) 0 0
Consolidated capital expenditures $ (1) $ 0 $ 0
v3.22.0.1
Segments and Geographic Data - Summary of Net Long-lived Assets Consisting of Property and Equipment (Details) - USD ($)
$ in Millions
Jan. 02, 2022
Jan. 03, 2021
Revenues from External Customers and Long-Lived Assets [Line Items]    
Total net long-lived assets $ 1,696 $ 1,454
United States    
Revenues from External Customers and Long-Lived Assets [Line Items]    
Total net long-lived assets 1,281 1,134
Singapore    
Revenues from External Customers and Long-Lived Assets [Line Items]    
Total net long-lived assets 218 150
United Kingdom    
Revenues from External Customers and Long-Lived Assets [Line Items]    
Total net long-lived assets 146 141
Other countries    
Revenues from External Customers and Long-Lived Assets [Line Items]    
Total net long-lived assets $ 51 $ 29
v3.22.0.1
Label Element Value
Accounting Standards Update [Extensible Enumeration] us-gaap_AccountingStandardsUpdateExtensibleList Accounting Standards Update 2016-02 [Member]