PFIZER INC, 10-K filed on 2/24/2022
Annual Report
v3.22.0.1
Cover Page - USD ($)
$ in Billions
 12 Months Ended
Dec. 31, 2021
Feb. 22, 2022
Jul. 04, 2021
Entity Information [Line Items]      
Document Type 10-K    
Document Annual Report true    
Document Period End Date Dec. 31, 2021    
Current Fiscal Year End Date --12-31    
Document Transition Report false    
Entity File Number 1-3619    
Entity Registrant Name PFIZER INC    
Entity Incorporation, State or Country Code DE    
Entity Tax Identification Number 13-5315170    
Entity Address, Address Line One 235 East 42nd Street    
Entity Address, City or Town New York    
Entity Address, State or Province NY    
Entity Address, Postal Zip Code 10017    
City Area Code 212    
Local Phone Number 733-2323    
Entity Well-known Seasoned Issuer Yes    
Entity Voluntary Filers No    
Entity Current Reporting Status Yes    
Entity Interactive Data Current Yes    
Entity Filer Category Large Accelerated Filer    
Entity Small Business false    
Entity Emerging Growth Company false    
ICFR Auditor Attestation Flag true    
Entity Shell Company false    
Entity Public Float     $ 223
Entity Common Stock, Shares Outstanding   5,623,346,471  
Entity Central Index Key 0000078003    
Document Fiscal Year Focus 2021    
Document Fiscal Period Focus FY    
Amendment Flag false    
Documents Incorporated by Reference
DOCUMENTS INCORPORATED BY REFERENCE
Portions of the Proxy Statement for the 2022 Annual Meeting of ShareholdersPart III
    
Common Stock [Member]      
Entity Information [Line Items]      
Title of 12(b) Security Common Stock, $.05 par value    
Trading Symbol PFE    
Security Exchange Name NYSE    
Notes Due 2022, 0.250% [Member]      
Entity Information [Line Items]      
Title of 12(b) Security 0.250% Notes due 2022    
Trading Symbol PFE22    
Security Exchange Name NYSE    
Notes Due 2027, 1.000% [Member]      
Entity Information [Line Items]      
Title of 12(b) Security 1.000% Notes due 2027    
Trading Symbol PFE27    
Security Exchange Name NYSE    
v3.22.0.1
Audit Information
 12 Months Ended
Dec. 31, 2021
Audit Information [Abstract]  
Auditor Name KPMG LLP
Auditor Location New York, NY
Auditor Firm ID 185
v3.22.0.1
Consolidated Statements of Income - USD ($)
shares in Millions, $ in Millions
 12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Income Statement [Abstract]      
Revenues [1] $ 81,288 $ 41,651 $ 40,905
Costs and expenses:      
Cost of sales [2] 30,821 8,484 8,054
Selling, informational and administrative expenses [2] 12,703 11,597 12,726
Research and development expenses [2] 13,829 9,393 8,385
Amortization of intangible assets 3,700 3,348 4,429
Restructuring charges and certain acquisition-related costs 802 579 601
(Gain) on completion of Consumer Healthcare JV transaction 0 (6) (8,107)
Other (income)/deductions––net (4,878) 1,219 3,497
Income from continuing operations before provision/(benefit) for taxes on income [3],[4],[5] 24,311 7,036 11,321
Provision/(benefit) for taxes on income 1,852 370 583
Income from continuing operations 22,459 6,666 10,738
Discontinued operations––net of tax (434) 2,529 5,318
Net income before allocation to noncontrolling interests 22,025 9,195 16,056
Less: Net income attributable to noncontrolling interests 45 36 29
Net income attributable to Pfizer Inc. common shareholders $ 21,979 $ 9,159 $ 16,026
Earnings per common share––basic:      
Income from continuing operations attributable to Pfizer Inc. common shareholders (in dollars per share) $ 4.00 $ 1.19 $ 1.92
Discontinued operations––net of tax (in dollars per share) (0.08) 0.46 0.95
Net income attributable to Pfizer Inc. common shareholders (in dollars per share) 3.92 1.65 2.88
Earnings per common share––diluted:      
Income from continuing operations attributable to Pfizer Inc. common shareholders (in dollars per share) 3.93 1.18 1.89
Discontinued operations––net of tax (in dollars per share) (0.08) 0.45 0.94
Net income attributable to Pfizer Inc. common shareholders (in dollars per share) $ 3.85 $ 1.63 $ 2.82
Weighted-average shares––basic 5,601 5,555 5,569
Weighted-average shares––diluted 5,708 5,632 5,675
[1] On December 31, 2021, we completed the sale of our Meridian subsidiary. Prior to its sale, Meridian was managed as part of the Hospital therapeutic area. On November 16, 2020, we completed the spin-off and the combination of our Upjohn Business with Mylan to form Viatris. On December 21, 2020, Pfizer and Viatris completed the termination of the Mylan-Japan collaboration. Beginning in the fourth quarter of 2021, the financial results of Meridian are reflected as discontinued operations for all periods presented. Beginning in the fourth quarter of 2020, the financial results of the Upjohn Business and Mylan-Japan collaboration were reflected as discontinued operations for all periods presented. Prior-period financial information has been restated, as appropriate. See Note 1A.
[2] Exclusive of amortization of intangible assets, except as disclosed in Note 1M.
[3] Income from continuing operations before provision/(benefit) for taxes on income. Biopharma’s earnings include dividend income from our investment in ViiV of $166 million in 2021, $278 million in 2020 and $220 million in 2019.
[4] 2020 v. 2019––The domestic loss in 2020 versus domestic income in 2019 was mainly related to the non-recurrence of the gain on the completion of the Consumer Healthcare JV transaction as well as higher asset impairment charges and higher R&D expenses. The increase in the international income was primarily related to the non-recurrence of the write off of assets contributed to the Consumer Healthcare JV as well as lower asset impairment charges and lower amortization of intangible assets.
[5] 2021 v. 2020––The domestic income in 2021 versus domestic loss in 2020 was mainly related to Comirnaty income, lower asset impairment charges, net periodic benefit credits in 2021 versus net periodic benefit costs in 2020 and higher net gains from equity securities, partially offset by higher R&D expenses. The increase in the international income was primarily related to Comirnaty income, net periodic benefit credits in 2021 versus net periodic benefit costs in 2020 and lower asset impairment charges.
v3.22.0.1
Consolidated Statements of Comprehensive Income - USD ($)
$ in Millions
 12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Statement of Comprehensive Income [Abstract]      
Net income before allocation to noncontrolling interests $ 22,025 $ 9,195 $ 16,056
Foreign currency translation adjustments, net (682) 772 675
Reclassification adjustments 0 (17) (288)
Other comprehensive income (loss), foreign currency transaction and translation adjustment, before tax, total (682) 755 387
Unrealized holding gains/(losses) on derivative financial instruments, net 526 (582) 476
Reclassification adjustments for (gains)/losses included in net income [1] 134 21 (664)
Other comprehensive income (loss), derivatives qualifying as hedges, before tax, total 660 (561) (188)
Unrealized holding gains/(losses) on available-for-sale securities, net (355) 361 (1)
Reclassification adjustments for (gains)/losses included in net income [2] (30) (188) 39
Other comprehensive income (loss), available-for-sale securities adjustment, before tax, total (384) 173 38
Benefit plans: prior service (costs)/credits and other, net 116 52 (7)
Reclassification adjustments related to amortization of prior service costs and other, net (154) (176) (181)
Reclassification adjustments related to curtailments of prior service costs and other, net (74) 0 (2)
Other (2) 0 1
Other comprehensive income (loss), benefit plans, prior service (costs)/credits, before tax, total (113) (124) (189)
Other comprehensive income/(loss), before tax (519) 243 48
Tax provision/(benefit) on other comprehensive income/(loss) 71 (227) 178
Other comprehensive income/(loss), net of tax (589) 471 (130)
Comprehensive income/(loss) before allocation to noncontrolling interests 21,435 9,666 15,926
Less: Comprehensive income/(loss) attributable to noncontrolling interests 43 27 18
Comprehensive income/(loss) attributable to Pfizer Inc. $ 21,393 $ 9,639 $ 15,908
[1] Reclassified into Other (income)/deductions—net and Cost of sales. See Note 7E.
[2] Reclassified into Other (income)/deductions—net.
v3.22.0.1
Consolidated Balance Sheets - USD ($)
$ in Millions
Dec. 31, 2021
Dec. 31, 2020
Assets    
Cash and cash equivalents $ 1,944 $ 1,786
Short-term investments 29,125 10,437
Trade accounts receivable, less allowance for doubtful accounts: 2021—$492; 2020—$508 11,479 7,913
Inventories [1] 9,059 8,020
Current tax assets 4,266 3,264
Other current assets 3,820 3,646
Total current assets 59,693 35,067
Equity-method investments 16,472 16,856
Long-term investments 5,054 3,406
Property, plant and equipment 14,882 13,745
Identifiable intangible assets [2] 25,146 28,337
Goodwill [3] 49,208 49,556
Noncurrent deferred tax assets and other noncurrent tax assets 3,341 2,383
Other noncurrent assets 7,679 4,879
Total assets 181,476 154,229
Liabilities and Equity    
Short-term borrowings, including current portion of long-term debt: 2021—$1,636; 2020—$2,002 2,241 2,703
Trade accounts payable 5,578 4,283
Dividends payable 2,249 2,162
Income taxes payable 1,266 1,049
Accrued compensation and related items 3,332 3,049
Deferred revenues 3,067 1,113
Other current liabilities 24,939 11,561
Total current liabilities 42,671 25,920
Long-term debt 36,195 37,133
Pension benefit obligations 3,489 4,766
Postretirement benefit obligations 235 645
Noncurrent deferred tax liabilities 349 4,063
Other taxes payable 11,331 11,560
Other noncurrent liabilities 9,743 6,669
Total liabilities 104,013 90,756
Commitments and Contingencies
Preferred stock, no par value, at stated value; 27 shares authorized; no shares issued or outstanding at December 31, 2021 and December 31, 2020 0 0
Common stock, $0.05 par value; 12,000 shares authorized; issued: 2021—9,471; 2020—9,407 473 470
Additional paid-in capital 90,591 88,674
Treasury stock, shares at cost: 2021—3,851; 2020—3,840 (111,361) (110,988)
Retained earnings 103,394 90,392
Accumulated other comprehensive loss (5,897) (5,310)
Total Pfizer Inc. shareholders’ equity 77,201 63,238
Equity attributable to noncontrolling interests 262 235
Total equity 77,462 63,473
Total liabilities and equity $ 181,476 $ 154,229
[1] The change from December 31, 2020 reflects increases for certain products, including inventory build for new product launches (primarily Comirnaty), network strategy and supply recovery, partially offset by decreases due to market demand.
[2] The decrease is primarily due to amortization, partially offset by the capitalization of the Comirnaty milestones described above.
[3] As a result of the reorganization of our commercial operations during the fourth quarter of 2021 (see Note 17), we were required to estimate the relative fair values of our PC1 and Hospital organizations to determine any reallocation of goodwill. We completed this analysis and determined that no goodwill was required to be reallocated. As a result, our entire goodwill balance continues to be assigned within the Biopharma reportable segment.
v3.22.0.1
Consolidated Balance Sheets (Parenthetical) - USD ($)
$ in Millions
Dec. 31, 2021
Dec. 31, 2020
Statement of Financial Position [Abstract]    
Allowance for doubtful accounts $ 492 $ 508
Current portion of long-term debt $ 1,636 $ 2,002
Preferred stock, shares authorized 27,000,000 27,000,000
Preferred stock, shares issued 0 0
Preferred stock, shares outstanding 0 0
Common stock, par value (in dollars per share) $ 0.05 $ 0.05
Common stock, shares authorized 12,000,000,000 12,000,000,000
Common stock, shares, issued 9,471,000,000 9,407,000,000
Treasury stock (in shares) 3,851,000,000 3,840,000,000
v3.22.0.1
Consolidated Statements of Equity - USD ($)
$ in Millions
Total
Shareholders’ Equity [Member]
Preferred Stock [Member]
Common Stock [Member]
Add’l Paid-In Capital [Member]
Treasury Stock [Member]
Retained Earnings [Member]
Accum. Other Comp. Loss [Member]
 [1]
Non-controlling Interests [Member]
Beginning balance (in shares) at Dec. 31, 2018     478,000,000 9,332,000,000   3,615,000,000      
Beginning balance at Dec. 31, 2018 $ 63,758 $ 63,407 $ 19 $ 467 $ 86,253 $ (101,610) $ 83,527 $ (5,249) $ 351
Increase (Decrease) in Stockholders' Equity [Roll Forward]                  
Net income 16,056 16,026         16,026   29
Other comprehensive income/(loss), net of tax (130) (118)           (118) [2] (11)
Cash dividends declared:                  
Common stock (8,174) (8,174)         (8,174)    
Preferred stock (1) (1)         (1)    
Noncontrolling interests (6)               (6)
Share-based payment transactions (in shares)       37,000,000   8,000,000      
Share-based payment transactions $ 894 894   $ 2 1,219 $ (326)      
Purchases of common stock (in shares) (213,000,000) [3]         (213,000,000)      
Purchases of common stock $ (8,865) [3] (8,865)       $ (8,865)      
Preferred stock conversions and redemptions (in shares)     (47,000,000)            
Preferred stock conversions and redemptions (4) (4) $ (2)   (3) $ 1      
Other (81) (21)     (40)   19   (60)
Ending balance (in shares) at Dec. 31, 2019     431,000,000 9,369,000,000   3,835,000,000      
Ending balance at Dec. 31, 2019 63,447 63,143 $ 17 $ 468 87,428 $ (110,801) 91,397 (5,367) 303
Increase (Decrease) in Stockholders' Equity [Roll Forward]                  
Net income 9,195 9,159         9,159   36
Other comprehensive income/(loss), net of tax 471 480           480 [2] (9)
Cash dividends declared:                  
Common stock (8,571) (8,571)         (8,571)    
Noncontrolling interests (91)               (91)
Share-based payment transactions (in shares)       37,000,000   6,000,000      
Share-based payment transactions $ 1,044 1,044   $ 2 1,261 $ (218)      
Purchases of common stock (in shares) 0                
Purchases of common stock $ 0                
Preferred stock conversions and redemptions (in shares) [4]     (431,000,000)     1,000,000      
Preferred stock conversions and redemptions [4] (1) (1) $ (17)   (15) $ 31      
Distribution of Upjohn business [5] (2,018) (2,015)         (1,592) (423) [6] (3)
Other (1)               (1)
Ending balance (in shares) at Dec. 31, 2020     0 9,407,000,000   3,840,000,000      
Ending balance at Dec. 31, 2020 63,473 63,238 $ 0 $ 470 88,674 $ (110,988) 90,392 (5,310) 235
Increase (Decrease) in Stockholders' Equity [Roll Forward]                  
Net income 22,025 21,979         21,979   45
Other comprehensive income/(loss), net of tax (589) (587)           (587) [2] (3)
Cash dividends declared:                  
Common stock (8,816) (8,816)         (8,816)    
Noncontrolling interests (8)               (8)
Share-based payment transactions (in shares)       64,000,000   11,000,000      
Share-based payment transactions $ 1,470 1,470   $ 3 1,917 $ (373) (77)    
Purchases of common stock (in shares) 0                
Purchases of common stock $ 0                
Other (92) (85)         (85)   (7)
Ending balance (in shares) at Dec. 31, 2021     0 9,471,000,000   3,851,000,000      
Ending balance at Dec. 31, 2021 $ 77,462 $ 77,201 $ 0 $ 473 $ 90,591 $ (111,361) $ 103,394 $ (5,897) $ 262
[1] Amounts include the impact of a change in accounting principle. See Note 1C.
[2] Amounts do not include foreign currency translation adjustments attributable to noncontrolling interests. Foreign currency translation adjustments include net losses in 2021 and net gains in 2020 and 2019 related to our equity-method investment in the Consumer Healthcare JV (see Note 2C), and the impact of our net investment hedging program.
[3] Represents shares purchased pursuant to the ASR with Goldman Sachs & Co. LLC entered into in February 2019, as well as open market share repurchases of $2.1 billion
[4] See Note 12.
[5] See Note 2B.
[6] For more information, see Note 2B.
v3.22.0.1
Consolidated Statements of Equity (Parenthetical) - $ / shares
 12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Statement of Stockholders' Equity [Abstract]      
Cash dividends declared per share (in dollars per share) $ 1.57 $ 1.53 $ 1.46
v3.22.0.1
Consolidated Statements of Cash Flows - USD ($)
$ in Millions
 12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Operating Activities      
Net income before allocation to noncontrolling interests $ 22,025 $ 9,195 $ 16,056
Discontinued operations––net of tax (434) 2,529 5,318
Net income from continuing operations before allocation to noncontrolling interests 22,459 6,666 10,738
Adjustments to reconcile net income before allocation to noncontrolling interests to net cash provided by operating activities:      
Depreciation and amortization 5,191 4,681 5,755
Asset write-offs and impairments 276 2,049 2,889
TCJA impact 0 0 (323)
Gain on completion of Consumer Healthcare JV transaction, net of cash conveyed [1] 0 (6) (8,254)
Deferred taxes from continuing operations (4,293) (1,575) 561
Share-based compensation expense 1,182 755 687
Benefit plan contributions in excess of expense/income (3,123) (1,242) (55)
Other adjustments, net (1,573) (479) (1,080)
Other changes in assets and liabilities, net of acquisitions and divestitures:      
Trade accounts receivable (3,811) (1,275) (1,124)
Inventories (1,125) (778) (1,071)
Other assets (1,057) (137) 847
Trade accounts payable 1,242 355 (341)
Other liabilities 18,721 2,768 861
Other tax accounts, net (1,166) (1,240) (3,074)
Net cash provided by operating activities from continuing operations 32,922 10,540 7,015
Net cash provided by/(used in) operating activities from discontinued operations (343) 3,863 5,572
Net cash provided by operating activities 32,580 14,403 12,588
Investing Activities      
Purchases of property, plant and equipment (2,711) (2,226) (2,046)
Purchases of short-term investments (38,457) (13,805) (6,835)
Proceeds from redemptions/sales of short-term investments 27,447 11,087 9,183
Net (purchases of)/proceeds from redemptions/sales of short-term investments with original maturities of three months or less (8,088) 920 6,925
Purchases of long-term investments (1,068) (597) (201)
Proceeds from redemptions/sales of long-term investments 649 723 232
Acquisitions of businesses, net of cash acquired 0 0 (10,861)
Other investing activities, net [1] (305) (265) (223)
Net cash provided by/(used in) investing activities from continuing operations (22,534) (4,162) (3,825)
Net cash provided by/(used in) investing activities from discontinued operations (12) (109) (120)
Net cash provided by/(used in) investing activities (22,546) (4,271) (3,945)
Financing Activities      
Proceeds from short-term borrowings 0 12,352 16,455
Principal payments on short-term borrowings 0 (22,197) (8,378)
Net (payments on)/proceeds from short-term borrowings with original maturities of three months or less (96) (4,129) 2,551
Proceeds from issuance of long-term debt 997 5,222 4,942
Principal payments on long-term debt (2,004) (4,003) (6,806)
Purchases of common stock 0 0 (8,865)
Cash dividends paid (8,729) (8,440) (8,043)
Other financing activities, net 16 (444) (342)
Net cash provided by/(used in) financing activities from continuing operations (9,816) (21,640) (8,485)
Net cash provided by/(used in) financing activities from discontinued operations 0 11,991 0
Net cash provided by/(used in) financing activities (9,816) (9,649) (8,485)
Effect of exchange-rate changes on cash and cash equivalents and restricted cash and cash equivalents (59) (8) (32)
Net increase/(decrease) in cash and cash equivalents and restricted cash and cash equivalents 159 475 125
Cash and cash equivalents and restricted cash and cash equivalents, at beginning of period 1,825 1,350 1,225
Cash and cash equivalents and restricted cash and cash equivalents, at end of period 1,983 1,825 1,350
Cash paid/(received) during the period for:      
Income taxes 7,427 3,153 3,664
Interest paid 1,467 1,641 1,587
Interest rate hedges (2) (20) (42)
Non-cash transactions:      
Right-of-use assets obtained in exchange for lease liabilities 1,943 410 314
Consumer Healthcare JV [Member]      
Adjustments to reconcile net income before allocation to noncontrolling interests to net cash provided by operating activities:      
Gain on completion of Consumer Healthcare JV transaction, net of cash conveyed     (8,300)
Non-cash transactions:      
Equity investment in exchange for Pfizer's assets [1] $ 0 $ 0 $ 15,711
[1] The $8.3 billion Gain on completion of Consumer Healthcare JV transaction, net of cash conveyed reflects the receipt of a 32% equity-method investment in the new company initially valued at $15.7 billion in exchange for net assets contributed of $7.6 billion and is presented in operating activities net of $146 million cash conveyed that is reflected in Other investing activities, net. See Note 2C.
v3.22.0.1
Consolidated Statements of Cash Flows (Parenthetical)
$ in Millions
 12 Months Ended
Dec. 31, 2019
USD ($)
Gain on completion of Consumer Healthcare JV transaction, net of cash conveyed $ 8,254 [1]
Consumer Healthcare JV [Member]  
Equity method investment, ownership percentage 32.00%
Gain on completion of Consumer Healthcare JV transaction, net of cash conveyed $ 8,300
Equity method investments 15,700
Deconsolidation net assets contributed 7,600
Deconsolidation, cash conveyed $ 146
[1] The $8.3 billion Gain on completion of Consumer Healthcare JV transaction, net of cash conveyed reflects the receipt of a 32% equity-method investment in the new company initially valued at $15.7 billion in exchange for net assets contributed of $7.6 billion and is presented in operating activities net of $146 million cash conveyed that is reflected in Other investing activities, net. See Note 2C.
v3.22.0.1
Basis of Presentation and Significant Accounting Policies
 12 Months Ended
Dec. 31, 2021
Organization, Consolidation and Presentation of Financial Statements [Abstract]  
Basis of Presentation and Significant Accounting Policies Basis of Presentation and Significant Accounting Policies
A. Basis of Presentation

The consolidated financial statements include the accounts of our parent company and all subsidiaries and are prepared in accordance with U.S. GAAP. The decision of whether or not to consolidate an entity for financial reporting purposes requires consideration of majority voting interests, as well as effective economic or other control over the entity. Typically, we do not seek control by means other than voting interests. For subsidiaries operating outside the U.S., the financial information is included as of and for the year ended November 30 for each year presented. Pfizer's fiscal year-end for U.S. subsidiaries is as of and for the year ended December 31 for each year presented. Substantially all unremitted earnings of international subsidiaries are free of legal and contractual restrictions. All significant transactions among our subsidiaries have been eliminated.

At the beginning of our fiscal fourth quarter of 2021, we reorganized our commercial operations and began to manage our commercial operations through a new global structure consisting of two operating segments, each led by a single manager: Biopharma, our innovative science-based biopharmaceutical business and PC1, our global contract development and manufacturing organization and a leading supplier of specialty active pharmaceutical ingredients. See Note 17. On December 31, 2021, we completed the sale of our Meridian subsidiary, the manufacturer of EpiPen and other auto-injector products. Prior to its sale, Meridian was managed within the Hospital therapeutic area. Beginning in the fourth quarter of 2021, the financial results of Meridian are reflected as discontinued operations for all periods presented. On December 21, 2020, Pfizer and Viatris completed the termination of a pre-existing strategic collaboration between Pfizer and Mylan for generic drugs in Japan (the Mylan-Japan collaboration) pursuant to an agreement dated November 13, 2020, and we transferred related inventories and operations that were part of the Mylan-Japan collaboration to Viatris. On November 16, 2020, we completed the spin-off and the combination of our Upjohn Business with Mylan to form Viatris. Beginning in the fourth quarter of 2020, the financial results of the Upjohn Business and the Mylan-Japan collaboration were reflected as discontinued operations for all periods presented. The assets and liabilities associated with Meridian and the Mylan-Japan collaboration are classified as assets and liabilities of discontinued operations as of December 31, 2020. Upon completion of the spin-off of the Upjohn Business on November 16, 2020, the Upjohn assets and liabilities were derecognized from our consolidated balance sheet and are reflected in Retained Earnings–Distribution of Upjohn Business in the consolidated statement of equity. Prior to the spin-off of the Upjohn Business in November 2020, the Upjohn Business, the Mylan-Japan collaboration and Meridian were managed as part of our former Upjohn operating segment. With the separation of the Upjohn Business, the Mylan-Japan collaboration and Meridian, as well as the formation of the Consumer Healthcare JV in 2019, Pfizer transformed into a more focused, global leader in science-based innovative medicines and vaccines. Certain prior year amounts have been reclassified to conform with the current year presentation. In addition, other acquisitions and business development activities completed in 2021, 2020 and 2019 impacted financial results in the periods presented. See Note 2.

Certain amounts in the consolidated financial statements and associated notes may not add due to rounding. All percentages have been calculated using unrounded amounts.
B. New Accounting Standard Adopted in 2021

On January 1, 2021, we adopted a new accounting standard for income tax that eliminates certain exceptions to the guidance related to the approach for intraperiod tax allocation, the methodology for calculating income taxes in an interim period and the recognition of deferred tax liabilities for outside basis differences. The new guidance also simplifies aspects of the accounting for franchise taxes and enacted changes in tax laws or rates and clarifies the accounting for transactions that result in a step-up in the tax basis of goodwill. The adoption of this guidance did not have a material impact on our consolidated financial statements.
C. Change in Accounting Principle

In the first quarter of 2021, we adopted a change in accounting principle to a more preferable policy under U.S. GAAP to immediately recognize actuarial gains and losses arising from the remeasurement of our pension and postretirement plans (MTM Accounting). Under the prior policy, we deferred recognition of these gains and losses in Accumulated other comprehensive loss. The accumulated actuarial gains/losses outside of a “corridor” were then amortized into net periodic benefit costs over the average remaining service period or the average life expectancy of participants. This change has been applied to all pension and postretirement plans on a retrospective basis for all prior periods presented, and as of January 1, 2019, resulted in a cumulative effect decrease to Retained earnings of $6.0 billion, with a corresponding offset to Accumulated other comprehensive loss. Each time a pension or postretirement plan is remeasured, the actuarial gain or loss is recognized immediately and classified as Other (income)/deductions––net.

We believe that MTM Accounting is a more preferable policy as it provides improved transparency of results and performance, better alignment with fair value accounting principles and a better reflection of current economic and interest rate trends on plan investments and assumptions and the actuarial impact of plan remeasurements.
The impacts of the adjustments on our consolidated financial statements are summarized as follows:
 Year Ended December 31,
202120202019
(MILLIONS, EXCEPT PER COMMON SHARE DATA)Previous
Accounting
Principle		Impact of ChangeAs ReportedPrevious Accounting PrincipleImpact of ChangeAs AdjustedPrevious Accounting PrincipleImpact of ChangeAs Adjusted
Consolidated Statements of Income:
(Gain) on completion of Consumer Healthcare JV transaction$— $— $— $(6)$— $(6)$(8,086)$(21)$(8,107)
Other (income)/deductions––net(2,820)(2,058)(4,878)672 547 1,219 3,264 233 3,497 
Income from continuing operations before provision/(benefit) for taxes on income22,253 2,058 24,311 7,584 (547)7,036 11,533 (212)11,321 
Provision/(benefit) for taxes on income1,399 453 1,852 496 (125)370 631 (48)583 
Discontinued operations––net of tax(434)— (434)2,564 (35)2,529 5,400 (82)5,318 
Net income before allocation to noncontrolling interests20,420 1,605 22,025 9,652 (457)9,195 16,302 (246)16,056 
Net income attributable to Pfizer Inc. common shareholders20,374 1,605 21,979 9,616 (457)9,159 16,273 (246)16,026 
Earnings per common share––basic:
Income from continuing operations attributable to Pfizer Inc. common shareholders$3.71 $0.29 $4.00 $1.27 $(0.08)$1.19 $1.95 $(0.03)$1.92 
Discontinued operations––net of tax(0.08)— (0.08)0.46 (0.01)0.46 0.97 (0.01)0.95 
Net income attributable to Pfizer Inc. common shareholders3.63 0.29 3.92 1.73 (0.08)1.65 2.92 (0.04)2.88 
Earnings per common share––diluted:
Income from continuing operations attributable to Pfizer Inc. common shareholders$3.65 $0.28 $3.93 $1.25 $(0.07)$1.18 $1.92 $(0.03)$1.89 
Discontinued operations––net of tax(0.08)— (0.08)0.46 (0.01)0.45 0.95 (0.01)0.94 
Net income attributable to Pfizer Inc. common shareholders3.57 0.28 3.85 1.71 (0.08)1.63 2.87 (0.04)2.82 
 Year Ended December 31,
202120202019
(MILLIONS)Previous
Accounting
Principle		Impact of ChangeAs ReportedPrevious Accounting PrincipleImpact of ChangeAs AdjustedPrevious Accounting PrincipleImpact of ChangeAs Adjusted
Consolidated Statements of Comprehensive Income:
Foreign currency translation adjustments, net$(731)$49 $(682)$957 $(185)$772 $654 $21 $675 
Benefit plans: actuarial gains/(losses), net1,565 (1,565)— (1,128)1,128 — (826)826 — 
Reclassification adjustments related to amortization285 (285)— 276 (276)— 241 (241)— 
Reclassification adjustments related to settlements, net209 (209)— 278 (278)— 274 (274)— 
Other49 (49)— (189)189 — 22 (22)— 
Tax provision/(benefit) on other comprehensive income/(loss)545 (475)71 (349)122 (227)115 63 178 
Consolidated Statements of Cash Flows:
Deferred taxes from continuing operations$(4,746)$453 $(4,293)$(1,449)$(125)$(1,575)$609 $(48)$561 
Benefit plan contributions in excess of expense/income(1,065)(2,058)(3,123)(1,790)547 (1,242)(288)233 (55)
 Year Ended December 31,
20212020
(MILLIONS)Previous
Accounting
Principle		Impact of ChangeAs ReportedPrevious Accounting PrincipleImpact of ChangeAs Adjusted
Consolidated Balance Sheets:
Noncurrent deferred tax assets and other noncurrent tax assets$3,320 $22 $3,341 $2,383 $— $2,383 
Other noncurrent assets7,679 — 7,679 4,879 — 4,879 
Pension benefit obligations3,489 — 3,489 4,766 — 4,766 
Retained earnings101,789 1,605 103,394 96,770 (6,378)90,392 
Accumulated other comprehensive loss(4,313)(1,583)(5,897)(11,688)6,378 (5,310)
D. Estimates and Assumptions

In preparing these financial statements, we use certain estimates and assumptions that affect reported amounts and disclosures. These estimates and assumptions can impact all elements of our financial statements. For example, in the consolidated statements of income, estimates are used when accounting for deductions from revenues, determining the cost of inventory that is sold, allocating cost in the form of depreciation and amortization, and estimating restructuring charges and the impact of contingencies, as well as determining provisions for taxes on income. On the consolidated balance sheets, estimates are used in determining the valuation and recoverability of assets, and in determining the reported amounts of liabilities, all of which also impact the consolidated statements of income. Certain estimates of fair value and amounts recorded in connection with acquisitions, revenue deductions, impairment reviews, restructuring-associated charges, investments and financial instruments, valuation allowances, pension and postretirement benefit plans, contingencies, share-based compensation, and other calculations can result from a complex series of judgments about future events and uncertainties and can rely heavily on estimates and assumptions.

Our estimates are often based on complex judgments and assumptions that we believe to be reasonable, but that can be inherently uncertain and unpredictable. If our estimates and assumptions are not representative of actual outcomes, our results could be materially impacted. As future events and their effects cannot be determined with precision, our estimates and assumptions may prove to be incomplete or inaccurate, or unanticipated events and circumstances may occur that might cause us to change those estimates and assumptions. We are subject to risks and uncertainties that may cause actual results to differ from estimated amounts, such as changes in the healthcare environment, competition, litigation, legislation and regulations. We regularly evaluate our estimates and assumptions using historical experience and expectations about the future. We adjust our estimates and assumptions when facts and circumstances indicate the need for change.
E. Acquisitions

Our consolidated financial statements include the operations of acquired businesses after the completion of the acquisitions. We account for acquired businesses using the acquisition method of accounting, which requires, among other things, that most assets acquired and liabilities assumed be recognized at their estimated fair values as of the acquisition date and that the fair value of acquired IPR&D be recorded on the balance sheet. Transaction costs are expensed as incurred. Any excess of the consideration transferred over the assigned values of the net assets acquired is recorded as goodwill. When we acquire net assets that do not constitute a business, as defined in U.S. GAAP, no goodwill is recognized and acquired IPR&D is expensed in Research and development expenses.

Contingent consideration in a business combination is included as part of the acquisition cost and is recognized at fair value as of the acquisition date. Fair value is generally estimated by using a probability-weighted discounted cash flow approach. See Note 16D. Any liability resulting from contingent consideration is remeasured to fair value at each reporting date until the contingency is resolved. These changes in fair value are recognized in earnings in Other (income)/deductions––net.

F. Fair Value

We measure certain assets and liabilities at fair value, either upon initial recognition or for subsequent accounting or reporting. We estimate fair value using an exit price approach, which requires, among other things, that we determine the price that would be received to sell an asset or paid to transfer a liability in an orderly market. The determination of an exit price is considered from the perspective of market participants, considering the highest and best use of non-financial assets and, for liabilities, assuming that the risk of non-performance will be the same before and after the transfer.

When estimating fair value, depending on the nature and complexity of the asset or liability, we may use one or all of the following techniques:
•Income approach, which is based on the present value of a future stream of net cash flows.
•Market approach, which is based on market prices and other information from market transactions involving identical or comparable assets or liabilities.
•Cost approach, which is based on the cost to acquire or construct comparable assets, less an allowance for functional and/or economic obsolescence.

Our fair value methodologies depend on the following types of inputs:
•Quoted prices for identical assets or liabilities in active markets (Level 1 inputs).
•Quoted prices for similar assets or liabilities in active markets, or quoted prices for identical or similar assets or liabilities in markets that are not active, or inputs other than quoted prices that are directly or indirectly observable, or inputs that are derived principally from, or corroborated by, observable market data by correlation or other means (Level 2 inputs).
•Unobservable inputs that reflect estimates and assumptions (Level 3 inputs).
The following inputs and valuation techniques are used to estimate the fair value of our financial assets and liabilities:
•Available-for-sale debt securities—third-party matrix-pricing model that uses significant inputs derived from or corroborated by observable market data and credit-adjusted yield curves.
•Equity securities with readily determinable fair values—quoted market prices and observable NAV prices.
•Derivative assets and liabilities—third-party matrix-pricing model that uses inputs derived from or corroborated by observable market data. Where applicable, these models use market-based observable inputs, including interest rate yield curves to discount future cash flow amounts, and forward and spot prices for currencies. The credit risk impact to our derivative financial instruments was not significant.
•Money market funds—observable NAV prices.
We periodically review the methodologies, inputs and outputs of third-party pricing services for reasonableness. Our procedures can include, for example, referencing other third-party pricing models, monitoring key observable inputs (like benchmark interest rates) and selectively performing test-comparisons of values with actual sales of financial instruments.
G. Foreign Currency Translation

For most of our international operations, local currencies have been determined to be the functional currencies. We translate functional currency assets and liabilities to their U.S. dollar equivalents at exchange rates in effect as of the balance sheet date and income and expense amounts at average exchange rates for the period. The U.S. dollar effects that arise from changing translation rates are recorded in Other comprehensive income/(loss). The effects of converting non-functional currency monetary assets and liabilities into the functional currency are recorded in Other (income)/deductions––net. For operations in highly inflationary economies, we translate monetary items at rates in effect as of the balance sheet date, with translation adjustments recorded in Other (income)/deductions––net, and we translate non-monetary items at historical rates.

H. Revenues and Trade Accounts Receivable

Revenue Recognition––We record revenues from product sales when there is a transfer of control of the product from us to the customer. We typically determine transfer of control based on when the product is shipped or delivered and title passes to the customer.
Our Sales Contracts––Sales on credit are typically under short-term contracts. Collections are based on market payment cycles common in various markets, with shorter cycles in the U.S. Sales are adjusted for sales allowances, chargebacks, rebates and sales returns and cash discounts. Sales returns occur due to LOE, product recalls or a changing competitive environment.
Deductions from Revenues––Our gross product revenues are subject to a variety of deductions, which generally are estimated and recorded in the same period that the revenues are recognized. Such variable consideration represents chargebacks, rebates, sales allowances and sales returns. These deductions represent estimates of the related obligations and, as such, knowledge and judgment is required when estimating the impact of these revenue deductions on gross sales for a reporting period.
Provisions for pharmaceutical sales returns––Provisions are based on a calculation for each market that incorporates the following, as appropriate: local returns policies and practices; historical returns as a percentage of sales; an understanding of the reasons for past returns; estimated shelf life by product; an estimate of the amount of time between shipment and return or lag time; and any other factors that could impact the estimate of future returns, such as LOE, product recalls or a changing competitive environment. Generally, returned products are destroyed, and customers are refunded the sales price in the form of a credit.
We record sales incentives as a reduction of revenues at the time the related revenues are recorded or when the incentive is offered, whichever is later. We estimate the cost of our sales incentives based on our historical experience with similar incentives programs to predict customer behavior.
The following outlines our common sales arrangements:
•Customers––Our prescription pharmaceutical products are sold principally to wholesalers, but we also sell directly to retailers, hospitals, clinics, government agencies and pharmacies. In the U.S., we primarily sell our vaccines products directly to the federal government, CDC, wholesalers, individual provider offices, retail pharmacies, and integrated delivery networks. Outside the U.S., we primarily sell our vaccines to government and non-government institutions. Prescription pharmaceutical products that ultimately are used by patients are generally covered under governmental programs, managed care programs and insurance programs, including those managed through PBMs, and are subject to sales allowances and/or rebates payable directly to those programs. Those sales allowances and rebates are generally negotiated, but government programs may have legislated amounts by type of product (e.g., patented or unpatented).
Specifically:
•In the U.S., we sell our products principally to distributors and hospitals. We also have contracts with managed care programs or PBMs and legislatively mandated contracts with the federal and state governments under which we provide rebates based on medicines utilized by the lives they cover. We record provisions for Medicare, Medicaid, and performance-based contract pharmaceutical rebates based upon our experience ratio of rebates paid and actual prescriptions written during prior periods. We apply the experience ratio to the respective period’s sales to determine the rebate accrual and related expense. This experience ratio is evaluated regularly to ensure that the historical trends are as current as practicable. We estimate discounts on branded prescription drug sales to Medicare Part D participants in the Medicare “coverage gap,” also known as the “doughnut hole,” based on the historical experience of beneficiary prescriptions and consideration of the utilization that is expected to result from the discount in the coverage gap. We evaluate this estimate regularly to ensure that the historical trends and future expectations are as current as practicable. For performance-based contract rebates, we also consider current contract terms, such as changes in formulary status and rebate rates.
•Outside the U.S., the majority of our pharmaceutical sales allowances are contractual or legislatively mandated and our estimates are based on actual invoiced sales within each period, which reduces the risk of variations in the estimation process. In certain European countries, rebates are calculated on the government’s total unbudgeted pharmaceutical spending or on specific product sales thresholds and we apply an estimated allocation factor against our actual invoiced sales to project the expected level of reimbursement. We obtain third-party information that helps us to monitor the adequacy of these accruals.
•Provisions for pharmaceutical chargebacks (primarily reimbursements to U.S. wholesalers for honoring contracted prices and legislated discounts to third parties) closely approximate actual amounts incurred, as we settle these deductions generally within two to five weeks of incurring the liability.
We recorded direct product sales and/or Alliance revenues of more than $1 billion for each of nine products in 2021, for each of seven products in 2020 and for each of six products in 2019. In the aggregate, these direct products sales and/or alliance product revenues represented 75% of our revenues in 2021, 54% of our revenues in 2020 and 49% of our revenues in 2019. See Note 17B for additional information. The loss or expiration of intellectual property rights can have a significant adverse effect on our revenues as our contracts with customers will generally be at lower selling prices and lower volumes due to added generic competition. We generally provide for higher sales returns during the period in which individual markets begin to near the loss or expiration of intellectual property rights.
Our accruals for Medicare, Medicaid and related state program and performance-based contract rebates, chargebacks, sales allowances and sales returns and cash discounts are as follows:
  As of December 31,
(MILLIONS)20212020
Reserve against Trade accounts receivable, less allowance for doubtful accounts
$1,077 $861 
Other current liabilities:
Accrued rebates3,811 3,017 
Other accruals528 432 
Other noncurrent liabilities
433 399 
Total accrued rebates and other sales-related accruals$5,850 $4,708 
Taxes collected from customers relating to product sales and remitted to governmental authorities are excluded from Revenues.

Trade Accounts Receivable—Trade accounts receivable are stated at their net realizable value. The allowance for credit losses reflects our best estimate of expected credit losses of the receivables portfolio determined on the basis of historical experience, current information, and forecasts of future economic conditions. In developing the estimate for expected credit losses, trade accounts receivables are segmented into pools of assets depending on market (U.S. versus international), delinquency status, and customer type (high risk versus low risk and government versus non-government), and fixed reserve percentages are established for each pool of trade accounts receivables.

In determining the reserve percentages for each pool of trade accounts receivables, we considered our historical experience with certain customers and customer types, regulatory and legal environments, country and political risk, and other relevant current and future forecasted macroeconomic factors. These credit risk indicators are monitored on a quarterly basis to determine whether there have been any changes in the economic environment that would indicate the established reserve percentages should be adjusted, and are considered on a regional basis to reflect more geographic-specific metrics. Additionally, write-offs and recoveries of customer receivables are tracked against collections on a quarterly basis to determine whether the reserve percentages remain appropriate. When management becomes aware of certain customer-specific factors that impact credit risk, specific allowances for these known troubled accounts are recorded. Trade accounts receivable are written off after all reasonable means to collect the full amount (including litigation, where appropriate) have been exhausted.
During 2021 and 2020, additions to the allowance for credit losses, write-offs and recoveries of customer receivables were not material to our consolidated financial statements.

I. Collaborative Arrangements

Payments to and from our collaboration partners are presented in our consolidated statements of income based on the nature of the arrangement (including its contractual terms), the nature of the payments and applicable accounting guidance. Under co-promotion agreements, we record the amounts received for our share of gross profits from our collaboration partners as alliance revenues, a component of Revenues, when our collaboration partners are the principal in the transaction and we receive a share of their net sales or profits. Alliance revenues are recorded as we perform co-promotion activities for the collaboration and the collaboration partners sell the products to their customers. The related expenses for selling and marketing these products including reimbursements to or from our collaboration partners for these costs are included in Selling, informational and administrative expenses. In collaborative arrangements where we manufacture a product for our collaboration partners, we record revenues when we transfer control of the product to our collaboration partners. In collaboration arrangements where we are the principal in the transaction, we record amounts paid to collaboration partners for their share of net sales or profits earned, and all royalty payments to collaboration partners as Cost of sales. Royalty payments received from collaboration partners are included in Other (income)/deductions—net.
Reimbursements to or from our collaboration partners for development costs are typically recorded in Research and development expenses. Upfront payments and pre-approval milestone payments due from us to our collaboration partners in development stage collaborations are recorded as Research and development expenses. Milestone payments due from us to our collaboration partners after regulatory approval has been attained for a medicine are recorded in Identifiable intangible assets—Developed technology rights. Upfront and pre-approval milestone payments earned from our collaboration partners by us are recognized in Other (income)/deductions—net over the development period for the products, when our performance obligations include providing R&D services to our collaboration partners. Upfront, pre-approval and post-approval milestone payments earned by us may be recognized in Other (income)/deductions—net immediately when earned or over other periods depending upon the nature of our performance obligations in the applicable collaboration. Where the milestone event is regulatory approval for a medicine, we generally recognize milestone payments due to us in the transaction price when regulatory approval in the applicable jurisdiction has been attained. We may recognize milestone payments due to us in the transaction price earlier than the milestone event in certain circumstances when recognition of the income would not be probable of a significant reversal.
J. Cost of Sales and Inventories

Inventories are recorded at the lower of cost or net realizable value. The cost of finished goods, work in process and raw materials is determined using average actual cost. We regularly review our inventories for impairment and reserves are established when necessary.

K. Selling, Informational and Administrative Expenses

Selling, informational and administrative costs are expensed as incurred. Among other things, these expenses include the internal and external costs of marketing, advertising, shipping and handling, information technology and legal defense. Advertising expenses totaled approximately $2.0 billion in 2021, $1.8 billion in 2020 and $2.3 billion in 2019. Production costs are expensed as incurred and the costs of TV, radio, and other electronic media and publications are expensed when the related advertising occurs.
L. Research and Development Expenses

R&D costs are expensed as incurred. These expenses include the costs of our proprietary R&D efforts, as well as costs incurred in connection with certain licensing arrangements. Before a compound receives regulatory approval, we record upfront and milestone payments we make to third parties under licensing arrangements as expense. Upfront payments are recorded when incurred, and milestone payments are recorded when the specific milestone has been achieved. Once a compound receives regulatory approval, we record any milestone payments in Identifiable intangible assets, less accumulated amortization and, unless the asset is determined to have an indefinite life, we typically amortize the payments on a straight-line basis over the remaining agreement term or the expected product life cycle, whichever is shorter.

M. Amortization of Intangible Assets, Depreciation and Certain Long-Lived Assets
Long-lived assets include:
•Property, plant and equipment, less accumulated depreciation—These assets are recorded at cost, including any significant improvements after purchase, less accumulated depreciation. Property, plant and equipment assets, other than land and construction in progress, are depreciated on a straight-line basis over the estimated useful life of the individual assets. Depreciation begins when the asset is ready for its intended use. For tax purposes, accelerated depreciation methods are used as allowed by tax laws.
•Identifiable intangible assets, less accumulated amortization—These assets are recorded at fair value at acquisition. Intangible assets with finite lives are amortized on a straight-line basis over their estimated useful lives. Intangible assets with indefinite lives are not amortized until a useful life can be determined.
•Goodwill—Goodwill represents the excess of the consideration transferred for an acquired business over the assigned values of its net assets. Goodwill is not amortized.
Amortization of finite-lived acquired intangible assets that contribute to our ability to sell, manufacture, research, market and distribute products, compounds and intellectual property is included in Amortization of intangible assets as these intangible assets benefit multiple business functions. Amortization of intangible assets that are for a single function and depreciation of property, plant and equipment are included in Cost of sales, Selling, informational and administrative expenses and/or Research and development expenses, as appropriate.
We review our long-lived assets for impairment indicators throughout the year. We perform impairment testing for indefinite-lived intangible assets and goodwill at least annually and for all other long-lived assets whenever impairment indicators are present. When necessary, we record impairments of long-lived assets for the amount by which the fair value is less than the carrying value of these assets.

Specifically:
•For finite-lived intangible assets, such as developed technology rights, and for other long-lived assets, such as property, plant and equipment, whenever impairment indicators are present, we calculate the undiscounted value of the projected cash flows for the asset, or asset group, and compare this estimated amount to the carrying amount. If the carrying amount is greater, we record an impairment loss for the excess of book value over fair value. In addition, in all cases of an impairment review, we reevaluate the remaining useful lives of the assets and modify them, as appropriate.
•For indefinite-lived intangible assets, such as brands and IPR&D assets, when necessary, we determine the fair value of the asset and record an impairment loss, if any, for the excess of book value over fair value. In addition, in all cases of an impairment review other than for IPR&D assets, we re-evaluate whether continuing to characterize the asset as indefinite-lived is appropriate.
•For goodwill, when necessary, we determine the fair value of each reporting unit and record an impairment loss, if any, for the excess of the book value of the reporting unit over the implied fair value.

N. Restructuring Charges and Other Costs Associated with Acquisitions and Cost-Reduction/Productivity Initiatives

We may incur restructuring charges in connection with acquisitions when we implement plans to restructure and integrate the acquired operations or in connection with our cost-reduction and productivity initiatives.
•In connection with acquisition activity, we typically incur costs associated with executing the transactions, integrating the acquired operations (which may include expenditures for consulting and the integration of systems and processes), and restructuring the combined company (which may include charges related to employees, assets and activities that will not continue in the combined company); and
•In connection with our cost-reduction/productivity initiatives, we typically incur costs and charges for site closings and other facility rationalization actions, workforce reductions and the expansion of shared services, including the development of global systems.
Included in Restructuring charges and certain acquisition-related costs are all restructuring charges, as well as certain other costs associated with acquiring and integrating an acquired business. If the restructuring action results in a change in the estimated useful life of an asset, that incremental impact is classified in Cost of sales, Selling, informational and administrative expenses and/or Research and development expenses, as appropriate. Employee termination costs are generally recorded when the actions are probable and estimable and include accrued severance benefits, pension and postretirement benefits, many of which may be paid out during periods after termination. Transaction costs, such as banking, legal, accounting and other similar costs incurred in connection with a business acquisition are expensed as incurred.
Our business and platform functions may be impacted by these actions, including sales and marketing, manufacturing and R&D, as well as our corporate enabling functions (such as digital, global real estate operations, legal, finance, human resources, worldwide public affairs, compliance and worldwide procurement).

O. Cash Equivalents and Statement of Cash Flows
Cash equivalents include items almost as liquid as cash, such as certificates of deposit and time deposits with maturity periods of three months or less when purchased. If items meeting this definition are part of a larger investment pool, we classify them as Short-term investments.
Cash flows for financial instruments designated as fair value or cash flow hedges may be included in operating, investing or financing activities, depending on the classification of the items being hedged. Cash flows for financial instruments designated as net investment hedges are classified according to the nature of the hedging instrument. Cash flows for financial instruments that do not qualify for hedge accounting treatment are classified according to their purpose and accounting nature.
P. Investments and Derivative Financial Instruments
The classification of an investment depends on the nature of the investment, our intent and ability to hold the investment, and the degree to which we may exercise influence. Our investments are primarily comprised of the following:
•Public equity securities with readily determinable fair values, which are carried at fair value, with changes in fair value reported in Other (income)/deductions—net.
•Available-for-sale debt securities, which are carried at fair value, with changes in fair value reported in Other comprehensive income/(loss) until realized.
•Held-to-maturity debt securities, which are carried at amortized cost.
•Private equity securities without readily determinable fair values and where we have no significant influence are measured at cost minus any impairment and plus or minus changes resulting from observable price changes in orderly transactions for the identical or a similar investment of the same issuer.
•For equity investments in common stock or in-substance common stock where we have significant influence over the financial and operating policies of the investee, we use the equity-method of accounting. Under the equity-method, we record our share of the investee’s income and expenses in Other (income)/deductions—net. The excess of the cost of the investment over our share of the underlying equity in the net assets of the investee as of the acquisition date is allocated to the identifiable assets and liabilities of the investee, with any remaining excess amount allocated to goodwill. Such investments are initially recorded at cost, which is the fair value of consideration paid and typically does not include contingent consideration.

Realized gains or losses on sales of investments are determined by using the specific identification cost method.

We regularly evaluate all of our financial assets for impairment. For investments in debt and equity, when a decline in fair value, if any, is determined, an impairment charge is recorded and a new cost basis in the investment is established.

Derivative financial instruments are carried at fair value in various balance sheet categories (see Note 7A), with changes in fair value reported in Net income or, for derivative financial instruments in certain qualifying hedging relationships, in Other comprehensive income/(loss) (see Note 7E).

Q. Tax Assets and Liabilities and Income Tax Contingencies

Tax Assets and Liabilities

Current tax assets primarily include (i) tax effects for intercompany transfers of inventory within our combined group, which are recognized in the consolidated statements of income when the inventory is sold to a third party and (ii) income tax receivables that are expected to be recovered either via refunds from taxing authorities or reductions to future tax obligations.

Deferred tax assets and liabilities are recognized for the expected future tax consequences of differences between the financial reporting and tax bases of assets and liabilities using enacted tax rates and laws. We provide a valuation allowance when we believe that our deferred tax assets are not recoverable based on an assessment of estimated future taxable income that incorporates ongoing, prudent and feasible tax-planning strategies, that would be implemented, if necessary, to realize the deferred tax assets. Amounts recorded for valuation allowances requires judgments about future income which can depend heavily on estimates and assumptions. All deferred tax assets and liabilities within the same tax jurisdiction are presented as a net amount in the noncurrent section of our consolidated balance sheet.
The TCJA subjects a U.S. shareholder to current tax on global intangible low-taxed income earned by certain foreign subsidiaries. The FASB Staff Q&A, Topic 740, No. 5, Accounting for Global Intangible Low-Taxed Income, states that we are permitted to make an accounting policy election to either recognize deferred taxes for temporary basis differences expected to reverse as global intangible low-taxed income in future years or provide for the tax expense related to such income in the year the tax is incurred. We elected to recognize deferred taxes for temporary differences expected to reverse as global intangible low-taxed income in future years.

Other non-current tax assets primarily represent our estimate of the potential tax benefits in one tax jurisdiction that could result from the payment of income taxes in another tax jurisdiction. These potential benefits generally result from cooperative efforts among taxing authorities, as required by tax treaties to minimize double taxation, commonly referred to as the competent authority process. The recoverability of these assets, which we believe to be more likely than not, is dependent upon the actual payment of taxes in one tax jurisdiction and, in some cases, the successful petition for recovery in another tax jurisdiction.

Other taxes payable as of December 31, 2021 and 2020 include liabilities for uncertain tax positions and the noncurrent portion of the repatriation tax liability for which we elected payment over eight years through 2026. For additional information, see Note 5D for uncertain tax positions and Note 5A for the repatriation tax liability and other estimates and assumptions in connection with the TCJA.

Income Tax Contingencies

We account for income tax contingencies using a benefit recognition model. If we consider that a tax position is more likely than not to be sustained upon audit, based solely on the technical merits of the position, we recognize all or a portion of the benefit. We measure the benefit by determining the amount that is greater than 50% likely of being realized upon settlement, presuming that the tax position is examined by the taxing authority with full knowledge of all relevant information.
We regularly monitor our position and subsequently recognize the unrecognized tax benefit: (i) if there are changes in tax law, analogous case law or there is new information that sufficiently raise the likelihood of prevailing on the technical merits of the position to “more likely than not”; (ii) if the statute of limitations expires; or (iii) if there is a completion of an audit resulting in a favorable settlement of that tax year with the appropriate agency. Liabilities for uncertain tax positions are classified as current only when we expect to pay cash within the next 12 months. Interest and penalties, if any, are recorded in Provision/(benefit) for taxes on income and are classified on our consolidated balance sheet with the related tax liability.

Our assessments are based on estimates and assumptions that have been deemed reasonable by management, but our estimates of unrecognized tax benefits and potential tax benefits may not be representative of actual outcomes, and variation from such estimates could materially affect our financial statements in the period of settlement or when the statutes of limitations expire, as we treat these events as discrete items in the period of resolution.

R. Pension and Postretirement Benefit Plans

The majority of our employees worldwide are covered by defined benefit pension plans, defined contribution plans or both. In the U.S., we have both IRC-qualified and supplemental (non-qualified) defined benefit plans and defined contribution plans, as well as other postretirement benefit plans consisting primarily of medical insurance for retirees and their eligible dependents. We recognize the overfunded or underfunded status of each of our defined benefit plans as an asset or liability. The obligations are generally measured at the actuarial present value of all benefits attributable to employee service rendered, as provided by the applicable benefit formula. Our pension and other postretirement obligations may be determined using assumptions such as discount rate, expected annual rate of return on plan assets, expected employee turnover and participant mortality. For our pension plans, the obligation may also include assumptions as to future compensation levels. For our other postretirement benefit plans, the obligation may include assumptions as to the expected cost of providing medical insurance benefits, as well as the extent to which those costs are shared with the employee or others (such as governmental programs). Plan assets are measured at fair value. Net periodic pension and postretirement benefit costs other than the service costs are recognized in Other (income)/deductions—net.

S. Legal and Environmental Contingencies

We and certain of our subsidiaries are subject to numerous contingencies arising in the ordinary course of business, such as patent litigation, product liability and other product-related litigation, commercial litigation, environmental claims and proceedings, government investigations and guarantees and indemnifications. In assessing contingencies related to legal and environmental proceedings that are pending against the Company, or unasserted claims that are probable of being asserted, we record accruals for these contingencies to the extent that we conclude that a loss is both probable and reasonably estimable. If some amount within a range of loss appears to be a better estimate than any other amount within the range, we accrue that amount. Alternatively, when no amount within a range of loss appears to be a better estimate than any other amount, we accrue the lowest amount in the range. We record anticipated recoveries under existing insurance contracts when recovery is assured.

T. Share-Based Payments

Our compensation programs can include share-based payments. Generally, grants under share-based payment programs are accounted for at fair value and these fair values are generally amortized on a straight-line basis over the vesting terms with the related costs recorded in Cost of sales, Selling, informational and administrative expenses and/or Research and development expenses, as appropriate.
v3.22.0.1
Acquisitions, Divestitures, Equity-Method Investments, Licensing Arrangements and Collaborative Arrangements
 12 Months Ended
Dec. 31, 2021
Business Combinations, Discontinued Operations And Disposal Groups, Collaborative Arrangements And Equity Method Investments [Abstract]  
Acquisitions, Divestitures, Equity-Method Investments, Licensing Arrangements and Collaborative Arrangements Acquisitions, Divestitures, Equity-Method Investments, Licensing Arrangements and Collaborative Arrangements
A. Acquisitions
Trillium

On November 17, 2021, we acquired all of the issued and outstanding common stock not already owned by Pfizer of Trillium, a clinical stage immuno-oncology company developing therapies targeting cancer immune evasion pathways and specific cell targeting approaches, for a price of $18.50 per share in cash, for total consideration of $2.0 billion, net of cash acquired. As a result, Trillium became our wholly owned subsidiary. We previously held a 2% ownership investment in Trillium. Trillium’s lead program, TTI-622, is an investigational fusion protein that is designed to block the inhibitory activity of CD47, a molecule that is overexpressed by a wide variety of tumors.

We accounted for the transaction as an asset acquisition since the lead asset, TTI-622, represented substantially all of the fair value of the gross assets acquired, which exclude cash acquired. At the acquisition date, we recorded a $2.1 billion charge representing an acquired IPR&D asset with no alternative future use in Research and development expenses, of which the $2.0 billion net cash consideration is presented as a cash outflow from operating activities. In connection with this acquisition, we recorded $256 million of assets acquired primarily consisting of cash and investments. Liabilities assumed were approximately $81 million.
Array
On July 30, 2019, we acquired Array, a commercial stage biopharmaceutical company focused on the discovery, development and commercialization of targeted small molecule medicines to treat cancer and other diseases of high unmet need, for $48 per share in cash. The total fair value of the consideration transferred was $11.2 billion ($10.9 billion, net of cash acquired). In addition, $157 million in payments to Array employees for the fair value of previously unvested stock options was recognized as post-closing compensation expense and recorded in Restructuring charges and certain acquisition-related costs (see Note 3). We financed the majority of the transaction with debt and the balance with existing cash.
Array’s portfolio includes Braftovi (encorafenib) and Mektovi (binimetinib), a broad pipeline of targeted cancer medicines in different stages of R&D, as well as a portfolio of out-licensed medicines, which may generate milestones and royalties over time.
The final allocation of the consideration transferred to the assets acquired and the liabilities assumed was completed in 2020. In connection with this acquisition, we recorded: (i) $6.3 billion in Identifiable intangible assets, consisting of $2.0 billion of Developed technology rights with a useful life of 16 years, $2.8 billion of IPR&D and $1.5 billion of Licensing agreements and other ($1.2 billion for technology in development––indefinite-lived licensing agreements and $360 million for developed technology––finite-lived licensing agreements with a useful life of 10 years), (ii) $6.1 billion of Goodwill, (iii) $1.1 billion of net deferred tax liabilities and (iv) $451 million of assumed long-term debt, which was paid in full in 2019.
In 2020, we recorded measurement period adjustments to the estimated fair values initially recorded in 2019, which resulted in a reduction in Identifiable intangible assets of approximately $900 million with a corresponding change to Goodwill and net deferred tax liabilities. The measurement period adjustments were recorded to better reflect market participant assumptions about facts and circumstances existing as of the acquisition date and did not have a material impact on our consolidated statement of income for the year ended December 31, 2020.
Therachon
On July 1, 2019, we acquired all the remaining shares of Therachon, a privately-held clinical-stage biotechnology company focused on rare diseases, with assets in development for the treatment of achondroplasia, a genetic condition and the most common form of short-limb dwarfism, for $340 million upfront, plus potential milestone payments of up to $470 million contingent on the achievement of key milestones in the development and commercialization of the lead asset. We accounted for the transaction as an asset acquisition since the lead asset represented substantially all the fair value of the gross assets acquired. The total fair value of the consideration transferred for Therachon was $322 million, which consisted of $317 million of cash and our previous $5 million investment in Therachon. In connection with this asset acquisition, we recorded a charge of $337 million in Research and development expenses.

B. Divestitures

Meridian
On December 31, 2021, we completed the sale of our Meridian subsidiary for approximately $51 million in cash and recognized a loss of approximately $167 million, net of tax, in Discontinued operations––net of tax. In connection with the sale, Pfizer and the purchaser of Meridian entered into various agreements to provide a framework for our relationship after the sale, including interim TSAs and a manufacturing supply agreement (MSA). The TSAs primarily involve Pfizer providing services related to information technology, among other activities, and are generally expected to be for terms of no more than 12 to 18 months post sale. The MSA is for a term of three years post sale with a two year extension period. No amounts were recorded under the above arrangements in 2021.
Upjohn Separation and Combination with Mylan
On November 16, 2020, we completed the spin-off and the combination of the Upjohn Business with Mylan (the Transactions) to form Viatris.
The Transactions were structured as an all-stock, Reverse Morris Trust transaction. Specifically, (i) we contributed the Upjohn Business to a wholly owned subsidiary, which was renamed Viatris, so that the Upjohn Business was separated from the remainder of our business (the Separation), (ii) following the Separation, we distributed, on a pro rata basis, all of the shares of Viatris common stock held by Pfizer to Pfizer stockholders as of the November 13, 2020 record date, such that each Pfizer stockholder as of the record date received approximately 0.124079 shares of Viatris common stock per share of Pfizer common stock (the Distribution); and (iii) immediately after the Distribution, the Upjohn Business combined with Mylan in a series of transactions in which Mylan shareholders received one share of Viatris common stock for each Mylan ordinary share held by such shareholder, subject to any applicable withholding taxes (the Combination). Prior to the Distribution, Viatris made a cash payment to Pfizer equal to $12.0 billion as partial consideration for the contribution of the Upjohn Business to Viatris. As of the closing of the Combination, Pfizer stockholders owned approximately 57% of the outstanding shares of Viatris common stock, and Mylan shareholders owned approximately 43% of the outstanding shares of Viatris common stock, in each case on a fully diluted, as-converted and as-exercised basis. The Transactions are generally expected to be tax free to Pfizer and Pfizer stockholders for U.S. tax purposes. Beginning November 16, 2020, Viatris operates both the Upjohn Business and Mylan as an independent publicly traded company, which is traded under the symbol “VTRS” on the NASDAQ.
In connection with the Transactions, in June 2020, Upjohn Inc. and Upjohn Finance B.V. completed privately placed debt offerings of $7.45 billion and €3.60 billion aggregate principal amounts, respectively, (approximately $11.4 billion) of senior unsecured notes and entered into other financing arrangements, including a $600 million delayed draw term loan agreement and a revolving credit facility agreement for up to $4.0 billion. Proceeds from the debt offerings and other financing arrangements were used to fund the $12.0 billion cash distribution Viatris made to Pfizer prior to the Distribution. We used the cash distribution proceeds to pay down commercial paper borrowings and redeem the $1.15 billion aggregate principal amount outstanding of our 1.95% senior unsecured notes that were due in June 2021 and $342 million aggregate principal amount outstanding of our 5.80% senior unsecured notes that were due in August 2023, before the maturity date. Interest expense for the $11.4 billion in debt securities incurred during 2020 is included in Discontinued operations––net of tax. Following the Separation and Combination of the Upjohn Business with Mylan, we are no longer the obligor or guarantor of any Upjohn debt or Upjohn financing arrangements.
As a result of the spin-off of the Upjohn Business, we distributed net assets of $1.6 billion as of November 16, 2020, which was reflected as a reduction to Retained earnings and reflects the change in accounting principle in the first quarter of 2021 to MTM Accounting. See Note 1C. Of this amount, $412 million represents cash transferred to the Upjohn Business, with the remainder considered a non-cash activity in the consolidated statement of cash flows for the year ended December 31, 2020. The spin-off also resulted in a net increase to Accumulated other comprehensive loss of $423 million for the derecognition of net gains on foreign currency translation adjustments of $397 million and prior service net credits associated with benefit plans of $26 million, which were reclassified to Retained earnings.
As a result of the separation of Upjohn, we incurred separation-related costs of $434 million in 2020 and $83 million in 2019, which are included in Discontinued operations––net of tax. These costs primarily relate to professional fees for regulatory filings and separation activities within finance, tax, legal and information system functions as well as investment banking fees.
In connection with the Transactions, Pfizer and Viatris entered into various agreements to effect the Separation and Combination to provide a framework for our relationship after the Combination, including a separation and distribution agreement, interim operating models, including agency arrangements, MSAs, TSAs, a tax matters agreement, and an employee matters agreement, among others. The interim agency operating model arrangements primarily include billings, collections and remittance of rebates that we are performing on a transitional basis on behalf of Viatris. Under the MSAs, Pfizer or Viatris, as the case may be, manufactures, labels and packages products for the other party. The terms of the MSAs range in initial duration from four to seven years post-Separation. The TSAs primarily involve Pfizer providing services to Viatris related to finance, information technology and human resource infrastructure and are generally expected to be for terms of no more than three years post-Separation. The amounts recorded under the above agreements were not material to our consolidated results of operations in 2021 and 2020. In addition, Pfizer and Mylan had a pre-existing arms-length commercial agreement, which is continuing with Viatris and is not material to Pfizer’s consolidated financial statements.
Net amounts due from Viatris under the above agreements were $53 million as of December 31, 2021 and $401 million as of December 31, 2020. The cash flows associated with the above agreements are included in Net cash provided by operating activities from continuing operations, except for a $277 million payment to Viatris made in 2021 pursuant to terms of the separation agreement, which is reported in Other financing activities, net, and was recorded as a payable to Viatris in Other current liabilities as of December 31, 2020.
Components of Discontinued operations––net of tax:
Year Ended December 31,(a)
(MILLIONS)202120202019
Revenues$277 $7,572 $10,845 
Costs and expenses:
Cost of sales204 2,106 2,173 
Selling, informational and administrative expenses26 1,682 1,624 
Research and development expenses9 224 265 
Amortization of intangible assets 45 224 181 
Restructuring charges and certain acquisition-related costs2 29 146 
Other (income)/deductions––net365 428 401 
Pre-tax income/(loss) from discontinued operations(375)2,879 6,056 
Provision/(benefit) for taxes on income(107)349 738 
Income/(loss) from discontinued operations––net of tax(268)2,529 5,318 
Pre-tax loss on sale of discontinued operations(211)— — 
Benefit for taxes on income(44)— — 
Loss on sale of discontinued operations––net of tax(167)— — 
Discontinued operations––net of tax$(434)$2,529 $5,318 
(a)In 2021, Discontinued operations—net of tax primarily includes (i) the operations of Meridian prior to its sale on December 31, 2021 recognized in Income/(loss) from discontinued operations—net of tax, which includes a pre-tax amount for a Multi-District Litigation relating to EpiPen against the Company in the U.S. District Court for the District of Kansas for $345 million; and (ii) the after tax loss of $167 million related to the sale of Meridian recognized in Loss on sale of discontinued operations––net of tax. To a much lesser extent, Discontinued operations—net of tax in 2021 also includes the operations of the Mylan-Japan collaboration prior to its termination on December 21, 2020 and post-closing adjustments directly related to our former Upjohn and Nutrition discontinued businesses, including adjustments for tax, benefits and legal-related matters recognized in Income/(loss) from discontinued operations—net of tax. In 2020 and 2019, Discontinued operations—net of tax relates to the operations of the Upjohn Business, Meridian and the Mylan-Japan collaboration and includes the change in accounting principle in the first quarter of 2021 to MTM Accounting. See Note 1C. In 2020, Discontinued operations—net of tax includes pre-tax interest expense of $116 million associated with the U.S. dollar and Euro denominated senior unsecured notes issued by Upjohn Inc. and Upjohn Finance B.V. in the second quarter of 2020 and pre-tax charges of $223 million related to the remeasurement of Euro debt issued by Upjohn Finance B.V. in the second quarter of 2020.
Components of assets and liabilities of discontinued operations and other assets held for sale:
As of December 31,(a)
(MILLIONS)20212020
Current assets of discontinued operations and other assets held for sale––Other current assets
$25 $215 
Property, plant and equipment$— $155 
Identifiable intangible assets— 134 
Other noncurrent assets— 29 
Noncurrent assets of discontinued operations––Other noncurrent assets
$— $319 
Current liabilities of discontinued operations––Other current liabilities
$— $74 
Noncurrent liabilities of discontinued operations––Other noncurrent liabilities
$— $16 
(a)Amounts as of December 31, 2021 represent property, plant and equipment held for sale. Amounts as of December 31, 2020 primarily relate to discontinued operations of our former Meridian subsidiary and the Mylan-Japan collaboration.
C. Equity-Method Investments
Formation of Consumer Healthcare JV
On July 31, 2019, we completed a transaction in which we and GSK combined our respective consumer healthcare businesses into a new JV that operates globally under the GSK Consumer Healthcare name. In exchange, we received a 32% equity stake in the new company and GSK owns the remaining 68%. Upon closing, we deconsolidated our Consumer Healthcare business and recognized a pre-tax gain of $8.1 billion ($5.4 billion, net of tax) in the third quarter of 2019 in (Gain) on completion of Consumer Healthcare JV transaction for the difference in the fair value of our 32% equity stake and the carrying value of our Consumer Healthcare business. Our financial results and our Consumer Healthcare segment’s operating results for 2019 reflect seven months of Consumer Healthcare segment domestic operations and eight months of Consumer Healthcare segment international operations. The financial results for 2021 and 2020 do not reflect any contribution from the Consumer Healthcare business.
In valuing our investment in the Consumer Healthcare JV, we used discounted cash flow techniques. Some of the more significant estimates and assumptions inherent in this approach include: the amount and timing of the projected net cash flows, which include the expected impact of competitive, legal or regulatory forces on the products; the long-term growth rate, which seeks to project the sustainable growth rate over the long term; the discount rate, which seeks to reflect our best estimate of the various risks inherent in the projected cash flows; and the tax rate, which seeks to incorporate the geographic diversity of the projected cash flows.
We are accounting for our interest in the Consumer Healthcare JV as an equity-method investment. The carrying value of our investment in the Consumer Healthcare JV is $16.3 billion as of December 31, 2021 and $16.7 billion as of December 31, 2020 and is reported as a private equity investment in Equity-method investments as of December 31, 2021 and 2020. The Consumer Healthcare JV is a foreign investee whose reporting currency is the U.K. pound, and therefore we translate its financial statements into U.S. dollars and recognize the impact of foreign currency translation adjustments in the carrying value of our investment and in other comprehensive income. The decrease in the value of our investment from December 31, 2020 to December 31, 2021 is primarily due to dividends totaling $499 million, as well as $384 million in pre-tax foreign currency translation adjustments (see Note 6), partially offset by our share of the JV’s earnings. We record our share of earnings from the Consumer Healthcare JV on a quarterly basis on a one-quarter lag in Other (income)/deductions––net commencing from August 1, 2019. Our total share of the JV’s earnings generated in the fourth quarter of 2020 and the first nine months of 2021, which we recorded in our operating results in 2021, was $495 million. Our total share of the JV’s earnings generated in the fourth quarter of 2019 and the first nine months of 2020, which we recorded in our operating results in 2020, was $417 million. Our total share of two months of the JV’s earnings generated in the third quarter of 2019, which we recorded in our operating results in the fourth quarter of 2019, was $47 million. As of the July 31, 2019 closing date, we estimated that the fair value of our investment in the Consumer Healthcare JV was $15.7 billion and that 32% of the underlying equity in the carrying value of the net assets of the Consumer Healthcare JV was $11.2 billion, resulting in an initial basis difference of approximately $4.5 billion. In the fourth quarter of 2019, we preliminarily completed the allocation of the basis difference, which resulted from the excess of the initial fair value of our investment over the underlying equity in the carrying value of the net assets of the JV, primarily to inventory, definite-lived intangible assets, indefinite-lived intangible assets, related deferred tax liabilities and equity method goodwill within the investment account. During the fourth quarter of 2019, the Consumer Healthcare JV revised the initial carrying value of the net assets of the JV and our 32% share of the underlying equity in the carrying value of the net assets of the Consumer Healthcare JV was reduced to $11.0 billion and our initial basis difference was increased to $4.8 billion. The adjustment was allocated to equity method goodwill within the investment account. We began recording the amortization of basis differences allocated to inventory, definite-lived intangible assets and related deferred tax liabilities in Other (income)/deductions––net commencing August 1, 2019. The total amortization and adjustment of basis differences resulting from the excess of the initial fair value of our investment over the underlying equity in the carrying value of the net assets of the JV is included in Other (income)/deductions––net and was not material to our results of operations in the periods presented. See Note 4. Amortization of basis differences on inventory and related deferred tax liabilities was completely recognized by the second quarter of 2020. Basis differences on definite-lived intangible assets and related deferred tax liabilities are being amortized over the lives of the underlying assets, which range from 8 to 20 years.
As a part of Pfizer in 2019, pre-tax income on a management basis for the Consumer Healthcare business was $654 million through July 31, 2019.
Summarized financial information for our equity method investee, the Consumer Healthcare JV, as of September 30, 2021, the most recent period available, and as of September 30, 2020 and for the periods ending September 30, 2021, 2020, and 2019 is as follows:
(MILLIONS)September 30, 2021September 30, 2020
Current assets$6,890 $6,614 
Noncurrent assets39,445 38,361 
Total assets
$46,335 $44,975 
Current liabilities$5,133 $5,246 
Noncurrent liabilities5,218 5,330 
Total liabilities
$10,351 $10,576 
Equity attributable to shareholders$35,705 $34,154 
Equity attributable to noncontrolling interests279 245 
Total net equity$35,984 $34,400 
For the Twelve Months EndingFor the Two Months Ending
(MILLIONS)September 30, 2021September 30, 2020September 30, 2019
Net sales$12,836 $12,720 $2,161 
Cost of sales(4,755)(5,439)(803)
Gross profit$8,081 $7,281 $1,358 
Income from continuing operations1,614 1,350 152 
Net income1,614 1,350 152 
Income attributable to shareholders1,547 1,307 148 
Investment in ViiV

In 2009, we and GSK created ViiV, which is focused on research, development and commercialization of human immunodeficiency virus (HIV) medicines. We own approximately 11.7% of ViiV, and prior to 2016 we accounted for our investment under the equity method due to the significant influence that we have over the operations of ViiV through our board representation and minority veto rights. We suspended application of the equity method to our investment in ViiV in 2016 when the carrying value of our investment was reduced to zero due to the recognition of cumulative equity method losses and dividends. Since 2016, we have recognized dividends from ViiV as income in Other (income)/deductions––net when earned, including dividends of $166 million in 2021, $278 million in 2020 and $220 million in 2019 (see Note 4).
Summarized financial information for our equity method investee, ViiV, as of December 31, 2021 and 2020 and for the years ending December 31, 2021, 2020, and 2019 is as follows:
As of December 31,
(MILLIONS)20212020
Current assets$3,608 $3,283 
Noncurrent assets3,563 3,381 
Total assets
$7,171 $6,664 
Current liabilities$3,497 $3,028 
Noncurrent liabilities6,536 6,370 
Total liabilities
$10,033 $9,398 
Total net equity/(deficit) attributable to shareholders$(2,862)$(2,734)
Year Ended December 31,
(MILLIONS)202120202019
Net sales$6,380 $6,224 $6,139 
Cost of sales(682)(574)(516)
Gross profit$5,698 $5,650 $5,623 
Income from continuing operations2,040 2,012 3,398 
Net income2,040 2,012 3,398 
Income attributable to shareholders2,040 2,012 3,398 
D. Licensing Arrangements
Agreement with Valneva
On April 30, 2020, we signed an agreement to co-develop and commercialize Valneva’s Lyme disease vaccine candidate, VLA15, which covers six serotypes that are prevalent in North America and Europe. Valneva and Pfizer will work closely together throughout the development of VLA15. Valneva is eligible to receive a total of up to $308 million in cash payments from us consisting of a $130 million upfront payment, which was paid and recorded in Research and development expenses in our second quarter of 2020, as well as $35 million in development milestones and $143 million in early commercialization milestones. Under the terms of the agreement, Valneva will fund 30% of all development costs through completion of the development program, and in return we will pay Valneva tiered royalties. We will lead late-stage development and have sole control over commercialization.

Agreement with Akcea
On October 4, 2019, we entered into a worldwide exclusive licensing agreement for AKCEA-ANGPTL3-LRx, an investigational antisense therapy being developed to treat patients with certain cardiovascular and metabolic diseases, with Akcea, a wholly-owned subsidiary of Ionis. The transaction closed in November 2019 and we made an upfront payment of $250 million to Akcea, which was recorded in Research and development expenses in our fourth quarter of 2019. On January 31, 2022, we and Ionis announced the discontinuation of the Pfizer-led clinical development program for the licensed product and that we would be returning the rights to the licensed product to Ionis.
E. Collaborative Arrangements
We enter into collaborative arrangements with respect to in-line medicines, as well as medicines in development that require completion of research and regulatory approval. Collaborative arrangements are contractual agreements with third parties that involve a joint operating activity, typically a research and/or commercialization effort, where both we and our partner are active participants in the activity and are exposed to the significant risks and rewards of the activity. Our rights and obligations under our collaborative arrangements vary. For example, we have agreements to co-promote pharmaceutical products discovered by us or other companies, and we have agreements where we partner to co-develop and/or participate together in commercializing, marketing, promoting, manufacturing and/or distributing a drug product.
Collaboration with Beam
On December 24, 2021, we entered into a multi-year research collaboration with Beam to utilize Beam’s in vivo base editing programs, which use mRNA and lipid nanoparticles, for three targets for rare genetic diseases of the liver, muscle and central nervous system. Under the terms of the agreement, Beam conducts all research activities through development candidate selection for three undisclosed targets, which are not included in Beam’s existing programs, and we may opt in to obtain exclusive licenses to each development candidate. Beam has a right to opt in, at the end of phase 1/2 studies, upon the payment by Beam of an option exercise fee, to a global co-development and co-commercialization agreement with respect to one program licensed under the collaboration pursuant to which we and Beam would share net profits as well as development and commercialization costs in a 65%/35% ratio (Pfizer/Beam). Upon entering into the agreement, we recorded $300 million in Research and development expenses in the fourth quarter of 2021 for an upfront payment due to Beam, and if we exercise our opt in to licenses for all three targets, Beam would be eligible for up to an additional $1.05 billion in development, regulatory and commercial milestone payments for a potential total deal consideration of up to $1.35 billion. Beam is also eligible to receive royalties on global net sales for each licensed program.
Collaboration with Arvinas
On July 21, 2021, we entered into a global collaboration with Arvinas to develop and commercialize ARV-471, an investigational oral PROTAC® (PROteolysis TArgeting Chimera) estrogen receptor protein degrader. The estrogen receptor is a well-known disease driver in most breast cancers. In connection with the agreement, we made an upfront cash payment of $650 million to Arvinas and we made a $350 million equity investment in the common stock of Arvinas. We recognized $706 million for the upfront payment and a premium paid on our equity investment in Research and development expenses in our third quarter of 2021. Arvinas is also eligible to receive up to $400 million in approval milestones and up to $1 billion in commercial milestones. The companies will equally share worldwide development costs, commercialization expenses and profits. As of December 31, 2021, we held a 6.5% equity stake of Arvinas.
Collaboration with Myovant
On December 26, 2020, we entered into a collaboration with Myovant to jointly develop and commercialize Orgovyx (relugolix) in advanced prostate cancer and Myfembree (relugolix 40 mg, estradiol 1.0 mg, and norethindrone acetate 0.5 mg) in women’s health in the U.S. and Canada. We also received an exclusive option to commercialize relugolix in oncology outside the U.S. and Canada, excluding certain Asian countries, which we declined to exercise. Under the terms of the agreement, the companies will equally share profits and allowable expenses for Orgovyx and Myfembree in the U.S. and Canada, with Myovant bearing our share of allowable expenses up to a maximum of $100 million in 2021 and up to a maximum of $50 million in 2022. We record our share of gross profits as Alliance revenue. Myovant remains responsible for regulatory interactions and drug supply and continues to lead clinical development for Myfembree. Myovant is entitled to receive up to $4.35 billion, including an upfront payment of $650 million, which was made in December 2020, $200 million in potential regulatory milestones for FDA approvals for Myfembree in women’s health, of which $100 million was paid to Myovant in July 2021 and recognized as Identifiable intangible assets—Developed technology rights, and tiered sales milestones of up to $3.5 billion in total for prostate cancer and for the combined women’s health indications. In connection with this transaction, in 2020 we recognized $499 million in Identifiable intangible assets––Developed technology rights and $151 million in Research and development expenses representing the relative fair value of the portion of the upfront payment allocated to the approved indication and unapproved indications of the product, respectively.
Collaboration with CStone
On September 29, 2020, we entered into a strategic collaboration with CStone to address oncological needs in China. The collaboration encompasses our $200 million upfront equity investment in CStone, the development and commercialization of CStone’s sugemalimab (CS1001, PD-L1 antibody) in mainland China, and a framework between the companies to bring additional oncology assets to the Greater China market. The transaction closed on October 9, 2020. As of December 31, 2021, we held a 9.8% equity stake of CStone.
Collaborations with BioNTech
On December 30, 2021, we entered into a new research, development and commercialization agreement to develop a potential first mRNA-based vaccine for the prevention of shingles (herpes zoster virus) based on BioNTech’s proprietary mRNA technology and our antigen technology. Under the terms of the agreement, we agreed to pay BioNTech $225 million, including an upfront cash payment of $75 million and an equity investment of $150 million. BioNTech is eligible to receive future regulatory and sales milestone payments of up to $200 million. In return, BioNTech agreed to pay us $25 million for our proprietary antigen technology. The net upfront payment to BioNTech was recorded to Research and development expenses in our fourth quarter of 2021. We and BioNTech will share development costs. We will have commercialization rights to the potential vaccine worldwide, excluding Germany, Turkey and certain developing countries where BioNTech will have commercialization rights. We and BioNTech will share gross profits from commercialization of any product.
On April 9, 2020, we signed a global agreement with BioNTech to co-develop a mRNA-based coronavirus vaccine program, BNT162b2, aimed at preventing COVID-19 infection. In connection with the April 2020 agreement, we made an upfront cash payment of $72 million and an equity investment in the common stock of BioNTech of $113 million. We recognized $98 million for the upfront payment and a premium paid on the equity investment in Research and development expenses in our second quarter of 2020. BioNTech became eligible to receive potential milestone payments of up to $563 million for a total consideration of $748 million. Under the terms of this agreement, we and BioNTech share gross profits and development costs equally after approval and successful commercialization of the vaccine, and we were responsible for all of
the development costs until commercialization of the vaccine. Thereafter, BioNTech was to repay us its 50 percent share of these development costs through reductions in gross profit sharing and milestone payments to BioNTech over time. On January 29, 2021, we and BioNTech signed an amended version of the April 2020 agreement. Under the January 2021 agreement, BioNTech paid us their 50 percent share of prior development costs in a lump sum payment during the first quarter of 2021. Further R&D costs are being shared equally. We have commercialization rights to the vaccine worldwide, excluding Germany and Turkey where BioNTech markets and distributes the vaccine under the agreement with us, and excluding China, Hong Kong, Macau and Taiwan, which are subject to a separate collaboration between BioNTech and Shanghai Fosun Pharmaceutical (Group) Co., Ltd. We recognize Revenues and Cost of sales on a gross basis in markets where we are commercializing the vaccine and we record our share of gross profits related to sales of the vaccine by BioNTech in Germany and Turkey in Alliance revenues.
We made an additional investment of $50 million in common stock of BioNTech as part of an underwritten equity offering by BioNTech, which closed in July 2020. As of December 31, 2021, we held an equity stake of 2.5% of BioNTech.
Summarized Financial Information for Collaborative Arrangements
The following provides the amounts and classification of payments (income/(expense)) between us and our collaboration partners:
Year Ended December 31,
(MILLIONS)202120202019
Revenues—Revenues(a)
$590 $284 $305 
Revenues—Alliance revenues(b)
7,652 5,418 4,648 
Total revenues from collaborative arrangements$8,241 $5,703 $4,953 
Cost of sales(c)
$(16,169)$(61)$(52)
Selling, informational and administrative expenses(d)
(175)(194)(176)
Research and development expenses(e)
(742)(192)104 
Other income/(deductions)—net(f)
820 567 362 
(a)Represents sales to our partners of products manufactured by us.
(b)Substantially all relates to amounts earned from our partners under co-promotion agreements. The increase in 2021 reflects increases in alliance revenues from Comirnaty, Eliquis and Xtandi, while the increase in 2020 reflects increases in alliance revenues from Eliquis and Xtandi.
(c)Primarily relates to amounts paid to collaboration partners for their share of net sales or profits earned in collaboration arrangements where we are the principal in the transaction, and cost of sales for inventory purchased from our partners. The increase in 2021 is primarily related to Comirnaty.
(d)Represents net reimbursements to our partners for selling, informational and administrative expenses incurred.
(e)Primarily relates to upfront payments and pre-approval milestone payments earned by our partners as well as net reimbursements.
(f)Primarily relates to royalties from our collaboration partners.
The amounts outlined in the above table do not include transactions with third parties other than our collaboration partners, or other costs for the products under the collaborative arrangements.
v3.22.0.1
Restructuring Charges and Other Costs Associated with Acquisitions and Cost-Reduction/Productivity Initiatives
 12 Months Ended
Dec. 31, 2021
Restructuring and Related Activities [Abstract]  
Restructuring Charges and Other Costs Associated with Acquisitions and Cost-Reduction/Productivity Initiatives Restructuring Charges and Other Costs Associated with Acquisitions and Cost-Reduction/Productivity Initiatives
In 2019, we substantially completed several multi-year initiatives focused on positioning us for future growth and creating a simpler, more efficient operating structure within each business.
A. Transforming to a More Focused Company Program
With the formation of the Consumer Healthcare JV in 2019 and the spin-off of our Upjohn Business in the fourth quarter of 2020, Pfizer has transformed into a more focused, global leader in science-based innovative medicines and vaccines. We have undertaken efforts to ensure our cost base and support model align appropriately with our new operating structure. While certain direct costs transferred to the Consumer Healthcare JV and to the Upjohn Business in connection with the spin-off, there are indirect costs which did not transfer. This program is primarily composed of the following three initiatives:
•We are taking steps to restructure our corporate enabling functions to appropriately support our business, R&D and PGS platform functions. We expect costs, primarily related to restructuring our corporate enabling functions, to total $1.6 billion, with substantially all costs to be cash expenditures. Actions include, among others, changes in location of certain activities, expanded use and co-location of centers of excellence and shared services, and increased use of digital technologies. The associated actions and the specific costs will primarily include severance and benefit plan impacts, exit costs as well as associated implementation costs.
•In addition, we are transforming our commercial go-to market model in the way we engage patients and physicians. We expect costs of $1.1 billion, with substantially all costs to be cash expenditures. Actions include, among others, centralization of certain activities and enhanced use of digital technologies. The costs for this effort primarily include severance and associated implementation costs.
•We are also optimizing our manufacturing network under this program and incurring one-time costs for cost-reduction initiatives related to our manufacturing operations. We expect to incur costs of $800 million, with approximately 25% of the costs to be non-cash. The costs for this effort include, among other things, severance costs, implementation costs, product transfer costs, site exit costs, as well as accelerated depreciation.
The program costs discussed above are expected to be incurred primarily from 2020 through 2022, and may be rounded and represent approximations.
From the start of this program in the fourth quarter of 2019 through December 31, 2021, we incurred costs of $2.2 billion, of which $856 million is associated with Biopharma ($712 million in 2021, $79 million in 2020 and $64 million in 2019).
B. Key Activities
In 2021 and 2020, we incurred costs of $1.3 billion and $838 million, respectively, composed primarily of the Transforming to a More Focused Company program. In 2019, we incurred costs of $820 million composed of $548 million for the 2017-2019 and Organizing for Growth initiatives, $288 million for the integration of Array, $94 million for the integration of Hospira, and $87 million for the Transforming to a More Focused Company program, partially offset by income of $197 million, primarily due to the reversal of certain accruals upon the effective favorable settlement of an IRS audit for multiple tax years and other acquisition-related initiatives.
The following summarizes acquisitions and cost-reduction/productivity initiatives costs and credits:
Year Ended December 31,
(MILLIONS)202120202019
Restructuring charges/(credits):
Employee terminations$680 $474 $108 
Asset impairments53 66 69 
Exit costs/(credits)8 (6)50 
Restructuring charges/(credits)(a)
741 535 227 
Transaction costs(b)
20 10 63 
Integration costs and other(c)
41 34 311 
Restructuring charges and certain acquisition-related costs
802 579 601 
Net periodic benefit costs/(credits) recorded in Other (income)/deductions––net(d)
(63)3 23 
Additional depreciation––asset restructuring recorded in our consolidated statements of income as follows(e):
Cost of sales63 21 29 
Selling, informational and administrative expenses23 — 3 
Research and development expenses— (3)8 
Total additional depreciation––asset restructuring
87 17 40 
Implementation costs recorded in our consolidated statements of income as follows(f):
Cost of sales45 40 61 
Selling, informational and administrative expenses426 197 73 
Research and development expenses1 1 22 
Total implementation costs
472 238 156 
Total costs associated with acquisitions and cost-reduction/productivity initiatives$1,298 $838 $820 
(a)Represents acquisition-related costs ($9 million credit in 2021 and $192 million credit in 2019) and cost reduction initiatives ($750 million charge in 2021, $535 million charge in 2020, and $418 million charge in 2019). 2021 and 2020 charges mainly represent employee termination costs for our Transforming to a More Focused Company cost-reduction program. 2019 restructuring charges mainly represent employee termination costs for cost-reduction and productivity initiatives, partially offset by the reversal of certain accruals related to our acquisition of Wyeth upon the effective favorable settlement of an IRS audit for multiple tax years (see Note 5B). The employee termination costs for 2019 were primarily for our improvements to operational effectiveness as part of the realignment of our business structure, and also included employee termination costs for the Transforming to a More Focused Company cost-reduction program.
(b)Represents external costs for banking, legal, accounting and other similar services.
(c)Represents external, incremental costs directly related to integrating acquired businesses, such as expenditures for consulting and the integration of systems and processes, and certain other qualifying costs. 2021 costs primarily related to our acquisition of Trillium. 2020 costs primarily related to our acquisition of Array. 2019 costs mainly related to our acquisitions of Array, including $157 million in payments to Array employees for the fair value of previously unvested stock options that was recognized as post-closing compensation expense (see Note 2A), and Hospira.
(d)Amounts include the impact of a change in accounting principle. See Note 1C.
(e)Represents the impact of changes in the estimated useful lives of assets involved in restructuring actions.
(f)Represents external, incremental costs directly related to implementing our non-acquisition-related cost-reduction/productivity initiatives.
The following summarizes the components and changes in restructuring accruals:
(MILLIONS)Employee
Termination
Costs		Asset
Impairment
Charges		Exit CostsAccrual
Balance, January 1, 2020
$770 $— $46 $816 
Provision474 66 (6)535 
Utilization and other(a)
(462)(66)(25)(554)
Balance, December 31, 2020(b)
782 — 15 798 
Provision680 53 8 741 
Utilization and other(a)
(449)(53)34 (468)
Balance, December 31, 2021(c)
$1,014 $— $57 $1,071 
(a)Includes adjustments for foreign currency translation.
(b)Included in Other current liabilities ($628 million) and Other noncurrent liabilities ($169 million).
(c)Included in Other current liabilities ($816 million) and Other noncurrent liabilities ($255 million).
v3.22.0.1
Other (Income)/Deductions - Net
 12 Months Ended
Dec. 31, 2021
Other Income and Expenses [Abstract]  
Other (Income)/Deductions - Net Other (Income)/Deductions—Net
Components of Other (income)/deductions––net include:
Year Ended December 31,
(MILLIONS)202120202019
Interest income$(36)$(73)$(225)
Interest expense(a)
1,291 1,449 1,573 
Net interest expense
1,255 1,376 1,348 
Royalty-related income(857)(770)(646)
Net (gains)/losses on asset disposals(99)237 (32)
Net (gains)/losses recognized during the period on equity securities(b)
(1,344)(540)(454)
Income from collaborations, out-licensing arrangements and sales of compound/product rights(c)
(396)(326)(168)
Net periodic benefit costs/(credits) other than service costs(d)
(2,547)311 305 
Certain legal matters, net(e)
182 28 292 
Certain asset impairments(f)
86 1,691 2,792 
Business and legal entity alignment costs(g)
— — 300 
Consumer Healthcare JV equity method (income)/loss(h)
(471)(298)(17)
Other, net(i)
(687)(491)(224)
Other (income)/deductions––net
$(4,878)$1,219 $3,497 
(a)Capitalized interest totaled $108 million in 2021, $96 million in 2020 and $88 million in 2019.
(b)2021 gains include, among other things, unrealized gains of $1.6 billion related to investments in BioNTech and Cerevel. 2020 gains included, among other things, unrealized gains of $405 million related to investments in BioNTech and SpringWorks Therapeutics, Inc. (SpringWorks). 2019 gains included, among other things, unrealized gains of $295 million related to investments in Cortexyme, Inc. and SpringWorks.
(c)2021 includes, among other things, $188 million of net collaboration income from BioNTech related to the COVID-19 vaccine and $97 million of milestone income from multiple licensees. 2020 included, among other things, (i) a $75 million upfront payment received from our sale of our CK1 assets to Biogen, (ii) $40 million of milestone income from Puma Biotechnology, Inc. related to Neratinib regulatory approvals in the EU, (iii) $30 million of milestone income from Lilly related to the first commercial sale in the U.S. of LOXO-292 for the treatment of RET fusion-positive NSCLC and (iv) $108 million in milestone income from multiple licensees. 2019 included, among other things, $78 million in milestone income from Mylan Pharmaceuticals Inc. related to the FDA’s approval and launch of Wixela Inhub®, a generic of Advair Diskus®(fluticasone propionate and salmeterol inhalation powder) and $52 million in milestone income from multiple licensees.
(d)Amounts include the impact of a change in accounting principle. See Notes 1C and 11. In 2019, other non-service cost components’ activity related to the Consumer Healthcare JV transaction, such as gain on settlements, were recorded in (Gain) on completion of Consumer Healthcare JV transaction.
(e)Includes legal reserves for certain pending legal matters.
(f)2020 represents intangible asset impairment charges associated with our Biopharma segment: (i) $900 million related to IPR&D assets for unapproved indications of certain cancer medicines, acquired in our Array acquisition, and reflected, among other things, updated commercial forecasts; (ii) $528 million related to Eucrisa, a finite-lived developed technology right acquired in our Anacor acquisition, and reflected updated commercial forecasts mainly reflecting competitive pressures; and (iii) $263 million related to finite-lived developed technology rights for certain generic sterile injectables acquired in our Hospira acquisition, and reflected updated commercial forecasts mainly reflecting competitive pressures.
2019 primarily included intangible asset impairment charges of $2.8 billion, mainly composed of $2.6 billion, related to Eucrisa, and reflected updated commercial forecasts mainly reflecting competitive pressures.
(g)Mainly represents incremental costs for the design, planning and implementation of our then new business structure, effective in the beginning of 2019, and primarily includes consulting, legal, tax and other advisory services.
(h)See Note 2C.
(i)2021 includes, among other things, (i) income net of costs associated with TSAs of $288 million; (ii) dividend income of $166 million from our investment in ViiV and (iii) charges of $142 million, reflecting the change in the fair value of contingent consideration. 2020 included, among other things, (i) dividend income of $278 million from our investment in ViiV; (ii) income net of costs associated with TSAs of $114 million and (iii) charges of $105 million, reflecting the change in the fair value of contingent consideration. 2019 included, among other things, (i) dividend income of $220 million from our investment in ViiV; (ii) charges of $152 million for external incremental costs, such as transaction costs and costs to separate our Consumer Healthcare business into a separate legal entity, associated with the formation of the Consumer Healthcare JV; and (iii) net losses on early retirement of debt of $138 million.
The asset impairment charges included in Other (income)/deductions––net are based on estimates of fair value.
v3.22.0.1
Tax Matters
 12 Months Ended
Dec. 31, 2021
Income Tax Disclosure [Abstract]  
Tax Matters Tax Matters
A. Taxes on Income from Continuing Operations
Components of Income from continuing operations before provision/(benefit) for taxes on income include:
 Year Ended December 31,
(MILLIONS)202120202019
United States$6,064 $(2,887)$7,332 
International18,247 9,924 3,988 
Income from continuing operations before provision/(benefit) for taxes on income(a), (b)
$24,311 $7,036 $11,321 
(a)2021 v. 2020––The domestic income in 2021 versus domestic loss in 2020 was mainly related to Comirnaty income, lower asset impairment charges, net periodic benefit credits in 2021 versus net periodic benefit costs in 2020 and higher net gains from equity securities, partially offset by higher R&D expenses. The increase in the international income was primarily related to Comirnaty income, net periodic benefit credits in 2021 versus net periodic benefit costs in 2020 and lower asset impairment charges.
(b)2020 v. 2019––The domestic loss in 2020 versus domestic income in 2019 was mainly related to the non-recurrence of the gain on the completion of the Consumer Healthcare JV transaction as well as higher asset impairment charges and higher R&D expenses. The increase in the international income was primarily related to the non-recurrence of the write off of assets contributed to the Consumer Healthcare JV as well as lower asset impairment charges and lower amortization of intangible assets.
Components of Provision/(benefit) for taxes on income based on the location of the taxing authorities include:
 Year Ended December 31,
(MILLIONS)202120202019
United States
Current income taxes:
Federal
$3,342 $372 $(1,887)
State and local
34 56 (186)
Deferred income taxes:
Federal
(3,850)(1,164)1,254 
State and local
(491)(131)276 
Total U.S. tax benefit
(964)(867)(543)
TCJA
Current income taxes
— — (135)
Deferred Income taxes
— — (187)
Total TCJA tax benefit
— — (323)
International
Current income taxes
2,769 1,517 2,418 
Deferred income taxes
48 (279)(969)
Total international tax provision
2,816 1,237 1,449 
Provision/(benefit) for taxes on income
$1,852 $370 $583 
Amounts discussed below are rounded to the nearest hundred million and represent approximations.
We elected, with the filing of our 2018 U.S. Federal Consolidated Income Tax Return, to pay our initial estimated $15 billion repatriation tax liability on accumulated post-1986 foreign earnings over eight years through 2026. The third annual installment of this liability was paid by its April 15, 2021 due date. The fourth annual installment is due April 18, 2022 and is reported in current Income taxes payable as of December 31, 2021. The remaining liability is reported in noncurrent Other taxes payable. Our obligations may vary as a result of changes in our uncertain tax positions and/or availability of attributes such as foreign tax and other credit carryforwards.
The changes in Provision/(benefit) for taxes on income impacting the effective tax rate year-over-year are summarized below:
2021 v. 2020

The higher effective tax rate in 2021 was mainly the result of:
•the change in the jurisdictional mix of earnings primarily related to Comirnaty; and
•lower tax benefits related to the impairment of intangible assets,
partially offset by:
•certain initiatives executed in the third quarter of 2021 associated with our investment in the Consumer Healthcare JV with GSK based on estimates and assumptions that we believe to be reasonable.
2020 v. 2019

The higher effective tax rate in 2020 was mainly the result of:
•the non-recurrence of the $1.4 billion tax benefits, representing taxes and interest, recorded in 2019 due to the favorable settlement of an IRS audit for multiple tax years;
•the non-recurrence of the tax benefits related to certain tax initiatives associated with the implementation of our then new business structure; and
•the non-recurrence of the tax benefits recorded in 2019 as a result of additional guidance issued by the U.S. Department of Treasury related to the TCJA, as well as:
•lower tax benefits related to the impairment of intangible assets,
partially offset by:
•the non-recurrence of the tax expense of $2.7 billion recorded in the third quarter of 2019 associated with the gain on the completion of the Consumer Healthcare JV transaction; and
•the favorable change in the jurisdictional mix of earnings as a result of operating fluctuations in the normal course of business.
In all years, federal, state and international net tax liabilities assumed or established as part of a business acquisition are not included in Provision/(benefit) for taxes on income (see Note 2A).
B. Tax Rate Reconciliation
The reconciliation of the U.S. statutory income tax rate to our effective tax rate for Income from continuing operations follows:
 Year Ended December 31,
202120202019
U.S. statutory income tax rate21.0 %21.0 %21.0 %
TCJA impact(a)
— — (2.9)
Taxation of non-U.S. operations (b), (c)
(4.3)(9.9)(4.7)
Tax settlements and resolution of certain tax positions(a)
(0.4)(2.7)(14.0)
Completion of Consumer Healthcare JV transaction(a)
— — 8.3 
Certain Consumer Healthcare JV initiatives(a)
(6.0)— — 
U.S. R&D tax credit(0.5)(1.4)(0.8)
Interest(d)
0.4 1.1 0.6 
All other, net(e)
(2.6)(2.8)(2.3)
Effective tax rate for income from continuing operations
7.6 %5.3 %5.2 %
(a)See Note 5A.
(b)For taxation of non-U.S. operations, this rate impact reflects the income tax rates and relative earnings in the locations where we do business outside the U.S., together with the U.S. tax cost on our international operations, changes in uncertain tax positions not included in the reconciling item called “Tax settlements and resolution of certain tax positions,” as well as changes in valuation allowances. Specifically: (i) the jurisdictional location of earnings is a significant component of our effective tax rate each year, and the rate impact of this component is influenced by the specific location of non-U.S. earnings and the level of such earnings as compared to our total earnings; (ii) the U.S. tax implications of our foreign operations is a significant component of our effective tax rate each year and generally offsets some of the reduction to our effective tax rate each year resulting from the jurisdictional location of earnings; (iii) the impact of certain tax initiatives; and (iv) the impact of changes in uncertain tax positions not included in the reconciling item called “Tax settlements and resolution of certain tax positions” is a component of our effective tax rate each year that can result in either an increase or decrease to our effective tax rate. The jurisdictional mix of earnings, which includes the impact of the location of earnings as well as the U.S. tax cost on our international operations, can vary as a result of operating fluctuations in the normal course of business and as a result of the extent and location of other income and expense items, such as restructuring charges, asset impairments and gains and losses on strategic business decisions. See also Note 5A for the components of pre-tax income and Provision/(benefit) for taxes on income, which is based on the location of the taxing authorities, and for information about settlements and other items impacting Provision/(benefit) for taxes on income.
(c)In all years, the reduction in our effective tax rate is a result of the jurisdictional location of earnings and is largely due to lower tax rates in certain jurisdictions, as well as manufacturing and other incentives for our subsidiaries in Singapore and, to a lesser extent, in Puerto Rico. We benefit from Puerto Rican tax incentives pursuant to a grant that expires during 2029. Under such grant, we are partially exempt from income, property and municipal taxes. In Singapore, we benefit from incentive tax rates effective through 2047 on income from manufacturing and other operations.
(d)Includes changes in interest related to our uncertain tax positions not included in the reconciling item called “Tax settlements and resolution of certain tax positions”.
(e)All other, net is primarily due to routine business operations.
C. Deferred Taxes
Components of our deferred tax assets and liabilities, shown before jurisdictional netting, follow:
2021 Deferred Tax*2020 Deferred Tax*
(MILLIONS)Assets(Liabilities)Assets(Liabilities)
Prepaid/deferred items(a)
$4,086 $(456)$3,114 $(336)
Inventories408 (56)276 (25)
Intangible assets(b)
1,778 (4,577)793 (5,355)
Property, plant and equipment(c)
117 (1,647)211 (1,220)
Employee benefits(d)
1,594 (178)1,981 (124)
Restructurings and other charges303 — 291 — 
Legal and product liability reserves373 — 382 — 
Net operating loss/tax credit carryforwards(e)
1,431 — 1,761 — 
Unremitted earnings— (45)— (46)
State and local tax adjustments197 — 171 — 
Investments(f)
70 (689)130 (3,545)
All other89 (68)80 (76)
10,446 (7,714)9,190 (10,726)
Valuation allowances(1,462)— (1,586)— 
Total deferred taxes$8,983 $(7,714)$7,604 $(10,726)
Net deferred tax asset/(liability)(g)
$1,269 $(3,123)
*The deferred tax assets and liabilities associated with global intangible low-taxed income are included in the relevant categories. See Note 1Q.
(a)The increase in net deferred tax assets in 2021 is primarily related to temporary differences associated with Comirnaty royalty accruals and the result of operating lease ROU liabilities recognized during the period.
(b)The increase in the deferred tax assets is primarily due to the acquisition of intangible assets relating to Trillium and the decrease in the 2021 deferred tax liabilities is primarily the result of amortization of intangible assets.
(c)The increase in net deferred tax liabilities in 2021 is primarily the result of operating lease ROU assets recognized during the period. See Note 15.
(d)The decrease in net deferred tax assets in 2021 is primarily the result of favorable pension plan asset performance reported in the period. See Note 11A.
(e)The amounts in 2021 and 2020 are reduced for unrecognized tax benefits of $3.0 billion and $3.0 billion, respectively, where we have net operating loss carryforwards, similar tax losses, and/or tax credit carryforwards that are available, under the tax law of the applicable jurisdiction, to settle any additional income taxes that would result from the disallowance of a tax position.
(f)The decrease in net deferred tax liabilities in 2021 is primarily due to certain initiatives executed in the third quarter of 2021 associated with our investment in the Consumer Healthcare JV.
(g)In 2021, Noncurrent deferred tax assets and other noncurrent tax assets ($1.6 billion), and Noncurrent deferred tax liabilities ($0.3 billion). In 2020, Noncurrent deferred tax assets and other noncurrent tax assets ($0.9 billion), and Noncurrent deferred tax liabilities ($4.1 billion).

We have carryforwards, primarily related to net operating and capital losses, general business credits, foreign tax credits and charitable contributions, which are available to reduce future U.S. federal and/or state, as well as international, income taxes payable with either an indefinite life or expiring at various times from 2022 to 2041. Certain of our U.S. net operating losses and general business credits are subject to limitations under IRC Section 382.

As of December 31, 2021, we have not made a U.S. tax provision on $55.0 billion of unremitted earnings of our international subsidiaries. As these earnings are intended to be indefinitely reinvested overseas, the determination of a hypothetical unrecognized deferred tax liability as of December 31, 2021 is not practicable. The amount of indefinitely reinvested earnings is based on estimates and assumptions and subject to management evaluation, and is subject to change in the normal course of business based on operational cash flow, completion of local statutory financial statements and the finalization of tax returns and audits, among other things. Accordingly, we regularly update our earnings and profits analysis for such events.

D. Tax Contingencies

For a description of our accounting policies associated with accounting for income tax contingencies, see Note 1Q.

Uncertain Tax Positions

As tax law is complex and often subject to varied interpretations, it is uncertain whether some of our tax positions will be sustained upon audit. As of December 31, 2021, we had $4.5 billion and as of December 31, 2020, we had $4.3 billion in net unrecognized tax benefits, excluding associated interest.
•Tax assets for uncertain tax positions primarily represent our estimate of the potential tax benefits in one tax jurisdiction that could result from the payment of income taxes in another tax jurisdiction. These potential benefits generally result from cooperative efforts among taxing authorities, as required by tax treaties to minimize double taxation, commonly referred to as the competent authority process. The recoverability of these assets, which we believe to be more likely than not, is dependent upon the actual payment of taxes in one tax jurisdiction and, in some cases, the successful petition for recovery in another tax jurisdiction. As of December 31, 2021, we had $1.5 billion in assets associated with uncertain tax positions. These amounts were included in Noncurrent deferred tax assets and other noncurrent tax assets ($1.4 billion) and Other taxes payable ($105 million). As of December 31, 2020, we had $1.3 billion in assets associated with uncertain tax positions. These amounts were included in Noncurrent deferred tax assets and other noncurrent tax assets ($1.1 billion), Noncurrent deferred tax liabilities ($122 million) and Other taxes payable ($46 million).
•Substantially all of these unrecognized tax benefits, if recognized, would impact our effective income tax rate.
The reconciliation of the beginning and ending amounts of gross unrecognized tax benefits follows:
(MILLIONS)202120202019
Balance, beginning$(5,595)$(5,381)$(6,259)
Acquisitions— 37 (44)
Divestitures(a)
— 265 — 
Increases based on tax positions taken during a prior period(b)
(111)(232)(36)
Decreases based on tax positions taken during a prior period(b), (c)
103 64 1,109 
Decreases based on settlements for a prior period(d)
24 15 100 
Increases based on tax positions taken during the current period(b)
(550)(411)(383)
Impact of foreign exchange22 (72)25 
Other, net(b), (e)
40 120 107 
Balance, ending(f)
$(6,068)$(5,595)$(5,381)
(a)For 2020, related to the separation of Upjohn. See Note 2B.
(b)Primarily included in Provision/(benefit) for taxes on income.
(c)Primarily related to effectively settling certain issues with the U.S. and foreign tax authorities. See Note 5A.
(d)Primarily related to cash payments and reductions of tax attributes.
(e)Primarily related to decreases as a result of a lapse of applicable statutes of limitations.
(f)In 2021, included in Income taxes payable ($19 million), Other current assets ($42 million) Noncurrent deferred tax assets and other noncurrent tax assets ($3.0 billion), Noncurrent deferred tax liabilities ($5 million) and Other taxes payable ($3.0 billion). In 2020, included in Income taxes payable ($34 million), Noncurrent deferred tax assets and other noncurrent tax assets ($18 million), Noncurrent deferred tax liabilities ($3.0 billion) and Other taxes payable ($2.5 billion).
•Interest related to our unrecognized tax benefits is recorded in accordance with the laws of each jurisdiction and is recorded primarily in Provision/(benefit) for taxes on income. In 2021 and 2020, we recorded net increases in interest of $108 million and $89 million, respectively. In 2019, we recorded a net decrease in interest of $564 million, resulting primarily from a settlement with the IRS. Gross accrued interest totaled $601 million as of December 31, 2021 (reflecting a decrease of $1 million as a result of cash payments) and gross
accrued interest totaled $493 million as of December 31, 2020 (reflecting a decrease of $5 million as a result of cash payments and a decrease of $75 million relating to the separation of Upjohn). In 2021 and 2020, these amounts were substantially all included in Other taxes payable. Accrued penalties are not significant. See also Note 5A.

Status of Tax Audits and Potential Impact on Accruals for Uncertain Tax Positions
The U.S. is one of our major tax jurisdictions, and we are regularly audited by the IRS. With respect to Pfizer, the IRS has issued Revenue Agent’s Reports (RARs) for tax years 2011-2013 and 2014-2015. We are not in agreement with the RARs and are currently appealing certain disputed issues. Tax years 2016-2018 are currently under audit. Tax years 2019-2021 are open, but not under audit. All other tax years are closed. In addition to the open audit years in the U.S., we have open audit years in certain major international tax jurisdictions such as Canada (2013-2021), Europe (2011-2021, primarily reflecting Ireland, the U.K., France, Italy, Spain and Germany), Asia Pacific (2011-2021, primarily reflecting China, Japan and Singapore) and Latin America (1998-2021, primarily reflecting Brazil).

Any settlements or statutes of limitations expirations could result in a significant decrease in our uncertain tax positions. We estimate that it is reasonably possible that within the next 12 months, our gross unrecognized tax benefits, exclusive of interest, could decrease by as much as $75 million, as a result of settlements with taxing authorities or the expiration of the statutes of limitations. Our assessments are based on estimates and assumptions that have been deemed reasonable by management, but our estimates of unrecognized tax benefits and potential tax benefits may not be representative of actual outcomes, and variation from such estimates could materially affect our financial statements in the period of settlement or when the statutes of limitations expire, as we treat these events as discrete items in the period of resolution. Finalizing audits with the relevant taxing authorities can include formal administrative and legal proceedings, and, as a result, it is difficult to estimate the timing and range of possible changes related to our uncertain tax positions, and such changes could be significant.

E. Tax Provision/(Benefit) on Other Comprehensive Income/(Loss)
Components of the Tax provision/(benefit) on other comprehensive income/(loss) include:
 Year Ended December 31,
(MILLIONS)202120202019
Foreign currency translation adjustments, net(a)
$43 $(119)$260 
Unrealized holding gains/(losses) on derivative financial instruments, net84 (88)83 
Reclassification adjustments for (gains)/losses included in net income29 (25)(125)
 114 (113)(42)
Unrealized holding gains/(losses) on available-for-sale securities, net(44)45 — 
Reclassification adjustments for (gains)/losses included in net income(4)(24)5 
 (48)22 5 
Benefit plans: prior service (costs)/credits and other, net27 12 (1)
Reclassification adjustments related to amortization of prior service costs and other, net(47)(31)(43)
Reclassification adjustments related to curtailments of prior service costs and other, net(17)— (1)
Other(1)1 — 
 (38)(17)(45)
Tax provision/(benefit) on other comprehensive income/(loss)$71 $(227)$178 
(a)Taxes are not provided for foreign currency translation adjustments relating to investments in international subsidiaries that are expected to be held indefinitely.
v3.22.0.1
Accumulated Other Comprehensive Loss, Excluding Noncontrolling Interests
 12 Months Ended
Dec. 31, 2021
Equity [Abstract]  
Accumulated Other Comprehensive Loss, Excluding Noncontrolling Interests Accumulated Other Comprehensive Loss, Excluding Noncontrolling Interests
The following summarizes the changes, net of tax, in Accumulated other comprehensive loss(a):
Net Unrealized Gains/(Losses)Benefit Plans
(MILLIONS)Foreign Currency Translation Adjustments Derivative Financial InstrumentsAvailable-For-Sale SecuritiesPrior Service (Costs)/ Credits and OtherAccumulated Other Comprehensive Income/(Loss)
Balance, January 1, 2019$(6,075)$167 $(68)$728 $(5,249)
Other comprehensive income/(loss)(b)
139 (146)33 (144)(118)
Balance, December 31, 2019(5,936)20 (35)584 (5,367)
Other comprehensive income/(loss)(b)
883 (448)151 (106)480 
Distribution of Upjohn Business(c)
(397)— — (26)(423)
Balance, December 31, 2020(5,450)(428)116 452 (5,310)
Other comprehensive income/(loss)(b)
(722)547 (336)(75)(587)
Balance, December 31, 2021$(6,172)$119 $(220)$377 $(5,897)
(a)Amounts include the impact of a change in accounting principle. See Note 1C.
(b)Amounts do not include foreign currency translation adjustments attributable to noncontrolling interests. Foreign currency translation adjustments include net losses in 2021 and net gains in 2020 and 2019 related to our equity-method investment in the Consumer Healthcare JV (see Note 2C), and the impact of our net investment hedging program.
(c)For more information, see Note 2B.
v3.22.0.1
Financial Instruments
 12 Months Ended
Dec. 31, 2021
Financial Instruments [Abstract]  
Financial Instruments Financial Instruments
A. Fair Value Measurements
Financial Assets and Liabilities Measured at Fair Value on a Recurring Basis and Fair Value Hierarchy, using a Market Approach:
As of December 31, 2021As of December 31, 2020
(MILLIONS)TotalLevel 1Level 2TotalLevel 1Level 2
Financial assets:
Short-term investments
Classified as equity securities with readily determinable fair values:
Money market funds$5,365 $— $5,365 $567 $— $567 
Classified as available-for-sale debt securities:
Government and agency—non-U.S.17,318 — 17,318 7,719 — 7,719 
Government and agency—U.S.4,050 — 4,050 982 — 982 
Corporate and other647 — 647 1,008 — 1,008 
22,014 — 22,014 9,709 — 9,709 
Total short-term investments27,379 — 27,379 10,276 — 10,276 
Other current assets
Derivative assets:
Interest rate contracts4 — 4 18 — 18 
Foreign exchange contracts704 — 704 234 — 234 
Total other current assets709 — 709 251 — 251 
Long-term investments
Classified as equity securities with readily determinable fair values(a)
3,876 3,849 27 2,809 2,776 32 
Classified as available-for-sale debt securities:
Government and agency—non-U.S.465 — 465 6 — 6 
Government and agency—U.S.6 — 6 121 — 121 
Corporate and other50 — 50 — — — 
521 — 521 128 — 128 
Total long-term investments4,397 3,849 548 2,936 2,776 160 
Other noncurrent assets
Derivative assets:
Interest rate contracts16 — 16 117 — 117 
Foreign exchange contracts242 — 242 5 — 5 
Total derivative assets259 — 259 122 — 122 
Insurance contracts(b)
808 — 808 693 — 693 
Total other noncurrent assets1,067 — 1,067 814 — 814 
Total assets$33,552 $3,849 $29,703 $14,278 $2,776 $11,501 
Financial liabilities:
Other current liabilities
Derivative liabilities:
Foreign exchange contracts$476 $— $476 $501 $— $501 
Total other current liabilities476 — 476 501 — 501 
Other noncurrent liabilities
Derivative liabilities:
Foreign exchange contracts405 — 405 599 — 599 
Total other noncurrent liabilities405 — 405 599 — 599 
Total liabilities$881 $— $881 $1,100 $— $1,100 
(a)Long-term equity securities of $194 million as of December 31, 2021 and $190 million as of December 31, 2020 were held in restricted trusts for U.S. non-qualified employee benefit plans.
(b)Includes life insurance policies held in restricted trusts for U.S. non-qualified employee benefit plans. The underlying invested assets in these contracts are marketable securities, which are carried at fair value, with changes in fair value recognized in Other (income)/deductions—net (see Note 4).

Financial Assets and Liabilities Not Measured at Fair Value on a Recurring Basis

The carrying value of Long-term debt, excluding the current portion was $36 billion as of December 31, 2021 and $37 billion as of December 31, 2020. The estimated fair value of such debt, using a market approach and Level 2 inputs, was $42 billion as of December 31, 2021 and $46 billion as of December 31, 2020.
The differences between the estimated fair values and carrying values of held-to-maturity debt securities, private equity securities, long-term receivables and short-term borrowings not measured at fair value on a recurring basis were not significant as of December 31, 2021 and 2020. The fair value measurements of our held-to-maturity debt securities and short-term borrowings are based on Level 2 inputs. The fair value measurements of our long-term receivables and private equity securities are based on Level 3 inputs.
B. Investments
Total Short-Term, Long-Term and Equity-Method Investments
The following summarizes our investments by classification type:
As of December 31,
(MILLIONS)20212020
Short-term investments
Equity securities with readily determinable fair values(a)
$5,365 $567 
Available-for-sale debt securities22,014 9,709 
Held-to-maturity debt securities1,746 161 
Total Short-term investments$29,125 $10,437 
Long-term investments
Equity securities with readily determinable fair values$3,876 $2,809 
Available-for-sale debt securities521 128 
Held-to-maturity debt securities34 37 
Private equity securities at cost(b)
623 432 
Total Long-term investments
$5,054 $3,406 
Equity-method investments16,472 16,856 
Total long-term investments and equity-method investments
$21,526 $20,262 
Held-to-maturity cash equivalents$268 $89 
(a)As of December 31, 2021 and 2020, includes money market funds primarily invested in U.S. Treasury and government debt.
(b)Represent investments in the life sciences sector.
Debt Securities
At December 31, 2021, our investment portfolio consisted of debt securities issued across diverse governments, corporate and financial institutions, which are investment-grade. The contractual or estimated maturities, are as follows:
As of December 31, 2021As of December 31, 2020
Gross UnrealizedMaturities (in Years)Gross Unrealized
(MILLIONS)Amortized CostGainsLossesFair ValueWithin 1Over 1
to 5		Over 5Amortized CostGainsLossesFair Value
Available-for-sale debt securities
Government and agency––non-U.S.
$18,032 $13 $(263)$17,783 $17,318 $465 $— $7,593 $136 $(4)$7,725 
Government and agency––U.S.
4,056 — (1)4,055 4,050 6 — 1,104 — (1)1,103 
Corporate and other698 — (1)697 647 50 — 1,006 2 — 1,008 
Held-to-maturity debt securities
Time deposits and other
947 — — 947 917 18 11 283 — — 283 
Government and agency––non-U.S.
1,102 — — 1,102 1,097 4 1 5 — — 5 
Total debt securities$24,835 $14 $(265)$24,584 $24,029 $543 $13 $9,991 $138 $(5)$10,124 
Any expected credit losses to these portfolios would be immaterial to our financial statements.
Equity Securities
The following presents the calculation of the portion of unrealized (gains)/losses that relates to equity securities, excluding equity method investments, held at the reporting date:
Year Ended December 31,
(MILLIONS)202120202019
Net (gains)/losses recognized during the period on equity securities(a)
$(1,344)$(540)$(454)
Less: Net (gains)/losses recognized during the period on equity securities sold during the period(80)(24)(25)
Net unrealized (gains)/losses during the reporting period on equity securities still held at the reporting date(b)
$(1,264)$(515)$(429)
(a)Reported in Other (income)/deductions––net. See Note 4.
(b)Included in net unrealized gains are observable price changes on equity securities without readily determinable fair values. As of December 31, 2021, there were cumulative impairments and downward adjustments of $97 million and upward adjustments of $156 million. Impairments, downward and upward adjustments were not significant in 2021, 2020 and 2019.
C. Short-Term Borrowings
Short-term borrowings include:
As of December 31,
(MILLIONS)20212020
Commercial paper $— $556 
Current portion of long-term debt, principal amount1,636 2,004 
Other short-term borrowings, principal amount(a)
605 145 
Total short-term borrowings, principal amount
2,241 2,705 
Net unamortized discounts, premiums and debt issuance costs— (2)
Total Short-term borrowings, including current portion of long-term debt, carried at historical proceeds, as adjusted
$2,241 $2,703 
(a)Primarily includes cash collateral. See Note 7F.
The weighted-average effective interest rate on commercial paper outstanding was approximately 0.13% as of December 31, 2020.
As of December 31, 2021, we had access to a $7 billion committed U.S. revolving credit facility expiring in 2026, which may be used for general corporate purposes including to support our commercial paper borrowings. In addition to the U.S. revolving credit facility, our lenders have provided us an additional $360 million in lines of credit, of which $322 million expire within one year. Essentially all lines of credit were unused as of December 31, 2021.
D. Long-Term Debt
The following outlines our senior unsecured long-term debt and the weighted-average stated interest rate by maturity:
As of December 31,
(MILLIONS)20212020
Notes due 2022 (1.0% for 2020)(a)
$— $1,728 
Notes due 2023 (3.2% for 2021 and 2020)
2,550 2,550 
Notes due 2024 (3.9% for 2021 and 2020)
2,250 2,250 
Notes due 2025 (0.8% for 2021 and 2020)
750 750 
Notes due 2026 (2.9% for 2021 and 2020)
3,000 3,000 
Notes due 2027 (2.1% for 2021 and 2.0% for 2020)
1,051 1,121 
Notes due 2028-2032 (3.1% for 2021 and 3.4% for 2020)
6,660 5,660 
Notes due 2033-2037 (5.6% for 2021 and 2020)
4,250 4,250 
Notes due 2038-2042 (5.5% for 2021 and 2020)
6,079 6,086 
Notes due 2043-2047 (3.7% for 2021 and 2020)
4,858 4,878 
Notes due 2048-2050 (3.6% for 2021 and 2020)
3,500 3,500 
Total long-term debt, principal amount34,948 35,774 
Net fair value adjustments related to hedging and purchase accounting1,438 1,562 
Net unamortized discounts, premiums and debt issuance costs(195)(207)
Other long-term debt4 4 
Total long-term debt, carried at historical proceeds, as adjusted$36,195 $37,133 
Current portion of long-term debt, carried at historical proceeds, as adjusted (not included above (1.0% for 2021 and 2.6% for 2020))
$1,636 $2,002 
(a)Reclassified to the current portion of long-term debt.
Our long-term debt outlined in the above table is generally redeemable by us at any time at varying redemption prices plus accrued and unpaid interest.
Issuances
In August 2021, we issued the following senior unsecured notes at an effective interest rate of 1.79%:
(MILLIONS)Principal
Interest RateMaturity Date
As of
December 31, 2021
1.750%(a)
August 18, 2031
$1,000 
(a)The notes may be redeemed by us at any time, in whole, or in part, at a redemption price plus accrued and unpaid interest.
In May 2020, we completed a public offering of $4.0 billion aggregate principal amount of senior unsecured notes with a weighted-average effective interest rate of 2.11% and in March 2020, we completed a public offering of $1.25 billion aggregate principal amount of senior unsecured notes with a weighted-average effective interest rate of 2.67%.

In March 2019, we completed a public offering of $5.0 billion aggregate principal amount of senior unsecured notes with a weighted-average effective interest rate of 3.57%.
Retirements
In November 2020, we repurchased all $1.15 billion and $342 million principal amount outstanding of the 1.95% senior unsecured notes due June 2021 and 5.80% senior unsecured notes due August 2023 and recorded a total net loss of $36 million, in Other (income)/deductions––net. See Note 2B.
In March 2020, we repurchased at par all $1.065 billion principal amount outstanding of our senior unsecured notes due in 2047.
In January 2019, we repurchased all €1.1 billion ($1.3 billion) principal amount outstanding of the 5.75% euro-denominated debt due June 2021 at a redemption value of €1.3 billion ($1.5 billion). We recorded a net loss of $138 million in Other (income)/deductions––net, which included the related termination of cross currency swaps.
E. Derivative Financial Instruments and Hedging Activities

Foreign Exchange Risk

A significant portion of our revenues, earnings and net investments in foreign affiliates is exposed to changes in foreign exchange rates. Where foreign exchange risk is not offset by other exposures, we manage our foreign exchange risk principally through the use of derivative financial instruments and foreign currency debt. These financial instruments serve to mitigate the impact on net income as a result of remeasurement into another currency, or against the impact of translation into U.S. dollars of certain foreign exchange-denominated transactions.
The derivative financial instruments primarily hedge or offset exposures in the euro, U.K. pound, Japanese yen and Canadian dollar.
•We hedge a portion of our forecasted intercompany inventory sales denominated in euro, Japanese yen, Canadian dollar, Chinese renminbi, U.K. pound and Australian dollar for up to two years.
•Under certain market conditions, we may seek to protect against possible declines in the reported net investments of our foreign business entities.

Changes in fair value are reported in earnings or in Other comprehensive income/(loss), depending on the nature and purpose of the financial instrument (hedge or offset relationship). For certain foreign exchange contracts, we exclude an amount from the assessment of hedge effectiveness and recognize the excluded amount through an amortization approach in earnings. The hedge relationships are as follows:
•Generally, we recognize the gains and losses on foreign exchange contracts that are designated as fair value hedges in earnings upon the recognition of the change in fair value of the hedged item. We also recognize the offsetting foreign exchange impact attributable to the hedged item in earnings.
•Generally, we record in Other comprehensive income/(loss) gains or losses on foreign exchange contracts that are designated as cash flow hedges and reclassify those amounts into earnings in the same period or periods during which the hedged transaction affects earnings.
•We record in Other comprehensive income/(loss) ––Foreign currency translation adjustments, net the foreign exchange gains and losses related to foreign exchange-denominated debt and foreign exchange contracts designated as a hedge of our net investments in foreign subsidiaries and reclassify those amounts into earnings upon the sale or substantial liquidation of our net investments.
•For foreign exchange contracts not designated as hedging instruments, we recognize the gains and losses immediately into earnings along with the earnings impact of the items they generally offset. These contracts take the opposite currency position of that reflected on the balance sheet to counterbalance the effect of any currency movement.
Interest Rate Risk

Our interest-bearing investments and borrowings are subject to interest rate risk. Depending on market conditions, we may change the profile of our outstanding debt or investments by entering into derivative financial instruments like interest rate swaps, either to hedge or offset the exposure to changes in the fair value of hedged items with fixed interest rates, or to convert variable rate debt or investments to fixed rates. The derivative financial instruments primarily hedge U.S. dollar fixed-rate debt.

We recognize the change in fair value on interest rate contracts that are designated as fair value hedges in earnings, as well as the offsetting earnings impact of the hedged risk attributable to the hedged item.
The following summarizes the fair value of the derivative financial instruments and notional amounts (including those reported as part of discontinued operations):
(MILLIONS)As of December 31, 2021As of December 31, 2020
Fair ValueFair Value
NotionalAssetLiabilityNotionalAssetLiability
Derivatives designated as hedging instruments:
Foreign exchange contracts(a)
$29,576 $787 $717 $24,369 $145 $1,005 
Interest rate contracts
2,250 21 — 1,950 135 — 
808 717 280 1,005 
Derivatives not designated as hedging instruments:
Foreign exchange contracts
$21,419 160 164 $15,063 94 95 
Total$968 $881 $373 $1,100 
(a)The notional amount of outstanding foreign exchange contracts hedging our intercompany forecasted inventory sales was $4.8 billion as of December 31, 2021 and $5.0 billion as of December 31, 2020.
The following summarizes information about the gains/(losses) incurred to hedge or offset operational foreign exchange or interest rate risk exposures (including those reported as part of discontinued operations):
 

Gains/(Losses)
Recognized in OID(a)
Gains/(Losses)
Recognized in OCI(a)
Gains/(Losses)
Reclassified from
OCI into OID and COS(a)
Year Ended December 31,
(MILLIONS)202120202021202020212020
Derivative Financial Instruments in Cash Flow Hedge Relationships:
      
Foreign exchange contracts(b)
$— $— $488 $(649)$(173)$(77)
Amount excluded from effectiveness testing and amortized into earnings(c)
— — 38 55 38 57 
Derivative Financial Instruments in Fair Value Hedge Relationships:
Interest rate contracts
(7)369 — — — — 
Hedged item
7 (369)— — — — 
Derivative Financial Instruments in Net Investment Hedge Relationships:
Foreign exchange contracts— — 468 (501)— — 
Amount excluded from effectiveness testing and amortized into earnings(c)
— — 52 181 109 154 
Non-Derivative Financial Instruments in Net Investment Hedge Relationships:(d)
Foreign currency short-term borrowings— — 78 8 — — 
Foreign currency long-term debt— — 86 (183)— — 
Derivative Financial Instruments Not Designated as Hedges:
Foreign exchange contracts(192)178 — — — — 
All other net(c)
— — 1 12 1 (1)
$(192)$178 $1,210 $(1,077)$(25)$133 
(a)OID = Other (income)/deductions—net, included in Other (income)/deductions—net in the consolidated statements of income. COS = Cost of Sales, included in Cost of sales in the consolidated statements of income. OCI = Other comprehensive income/(loss), included in the consolidated statements of comprehensive income.
(b)The amounts reclassified from OCI into COS were:
•a net loss of $89 million in 2021; and
•a net gain of $172 million in 2020 (including a gain of $22 million reported in Discontinued operations––net of tax).
The remaining amounts were reclassified from OCI into OID. Based on year-end foreign exchange rates that are subject to change, we expect to reclassify a pre-tax gain of $362 million within the next 12 months into income. The maximum length of time over which we are hedging our exposure to the variability in future foreign exchange cash flows is approximately 21 years and relates to foreign currency debt.
(c)The amounts reclassified from OCI were reclassified into OID.
(d)Short-term borrowings and long-term debt include foreign currency borrowings which are used as net investment hedges. The short-term borrowings carrying value as of December 31, 2021 was $1.1 billion. The long-term debt carrying values as of December 31, 2021 and December 31, 2020 were $844 million and $2.1 billion, respectively.
The following summarizes cumulative basis adjustments to our long-term debt in fair value hedges:
As of December 31, 2021As of December 31, 2020
Cumulative Amount of Fair
Value Hedging Adjustment
Increase/(Decrease) to
Carrying Amount		Cumulative Amount of Fair
Value Hedging Adjustment Increase/(Decrease) to
Carrying Amount
(MILLIONS)
Carrying Amount of Hedged Assets/Liabilities(a)
Active
Hedging
Relationships		Discontinued Hedging Relationships
Carrying Amount of Hedged Assets/Liabilities(a)
Active Hedging RelationshipsDiscontinued Hedging Relationships
Long-term debt$2,233 $16 $1,154 $2,016 $117 $1,149 
(a)Carrying amounts exclude the cumulative amount of fair value hedging adjustments.
F. Credit Risk

On an ongoing basis, we monitor and review the credit risk of our customers, financial institutions and exposures in our investment portfolio.

With respect to our trade accounts receivable, we monitor the creditworthiness of our customers to which we grant credit in the normal course of business. In general, there is no requirement for collateral from customers. For additional information on our trade accounts receivable and
allowance for credit losses, see Note 1H. A significant portion of our trade accounts receivable balances are due from wholesalers and governments. For additional information on our trade accounts receivables with significant customers, see Note 17C.

With respect to our investments, we monitor concentrations of credit risk associated with government, government agency, and corporate issuers of securities. Investments are placed in instruments that are investment grade and are primarily short in duration. Exposure limits are established to limit a concentration with any single credit counterparty. As of December 31, 2021, the largest investment exposures in our portfolio represent primarily sovereign debt instruments issued by the U.S., Canada, Japan, U.K., Germany, France, Australia, and Switzerland.

With respect to our derivative financial instrument agreements with financial institutions, we do not expect to incur a significant loss from failure of any counterparty. Derivative financial instruments are executed under International Swaps and Derivatives Association (ISDA) master agreements with credit-support annexes that contain zero threshold provisions requiring collateral to be exchanged daily depending on levels of exposure. As a result, there are no significant concentrations of credit risk with any individual financial institution. As of December 31, 2021, the aggregate fair value of these derivative financial instruments that are in a net payable position was $372 million, for which we have posted collateral of $382 million with a corresponding amount reported in Short-term investments. As of December 31, 2021, the aggregate fair value of our derivative financial instruments that are in a net receivable position was $477 million, for which we have received collateral of $581 million with a corresponding amount reported in Short-term borrowings, including current portion of long-term debt.
v3.22.0.1
Other Financial Information
 12 Months Ended
Dec. 31, 2021
Other Financial Information [Abstract]  
Other Financial Information Other Financial Information
A. Inventories
The following summarizes the components of Inventories:
As of December 31,
(MILLIONS)20212020
Finished goods$3,641 $2,867 
Work in process4,424 4,436 
Raw materials and supplies994 716 
Inventories(a)
$9,059 $8,020 
Noncurrent inventories not included above(b)
$939 $890 
(a)The change from December 31, 2020 reflects increases for certain products, including inventory build for new product launches (primarily Comirnaty), network strategy and supply recovery, partially offset by decreases due to market demand.
(b)Included in Other noncurrent assets. There are no recoverability issues for these amounts.
B. Other Current Liabilities
Other current liabilities includes, among other things, amounts payable to BioNTech for the gross profit split for Comirnaty, which totaled $9.7 billion as of December 31, 2021 and $25 million as of December 31, 2020.
v3.22.0.1
Property, Plant and Equipment (PP&E)
 12 Months Ended
Dec. 31, 2021
Property, Plant and Equipment [Abstract]  
Property, Plant and Equipment (PP&E) Property, Plant and Equipment (PP&E)
The following summarizes the components of Property, plant and equipment:
 Useful LivesAs of December 31,
(MILLIONS)(Years)  20212020
Land-$423 $443 
Buildings
33-50
9,001 8,998 
Machinery and equipment
8-20
12,252 11,000 
Furniture, fixtures and other
3-12.5
4,457 4,484 
Construction in progress-3,822 3,481 
29,955 28,406 
Less: Accumulated depreciation15,074 14,661 
Property, plant and equipment$14,882 $13,745 
The following provides long-lived assets by geographic area:
 As of December 31,
(MILLIONS)20212020
Property, plant and equipment
United States$8,385 $7,666 
Developed Europe5,094 4,775 
Developed Rest of World347 413 
Emerging Markets1,056 890 
Property, plant and equipment$14,882 $13,745 
v3.22.0.1
Identifiable Intangible Assets and Goodwill
 12 Months Ended
Dec. 31, 2021
Goodwill and Intangible Assets Disclosure [Abstract]  
Identifiable Intangible Assets and Goodwill Identifiable Intangible Assets and Goodwill
A. Identifiable Intangible Assets
The following summarizes the components of Identifiable intangible assets:
 As of December 31, 2021As of December 31, 2020
(MILLIONS)Gross
Carrying
Amount		Accumulated
Amortization		Identifiable
Intangible
Assets, less
Accumulated
Amortization		Gross
Carrying
Amount		Accumulated
Amortization		Identifiable
Intangible
Assets, less
Accumulated
Amortization
Finite-lived intangible assets
Developed technology rights(a)
$73,346 $(53,732)$19,614 $73,040 $(50,532)$22,508 
Brands922 (807)115 922 (774)148 
Licensing agreements and other2,284 (1,299)985 2,292 (1,187)1,106 
76,552 (55,838)20,714 76,255 (52,493)23,762 
Indefinite-lived intangible assets
Brands827 827 827 827 
IPR&D3,092 3,092 3,175 3,175 
Licensing agreements and other513 513 573 573 
4,432 4,432 4,575 4,575 
Identifiable intangible assets(b)
$80,984 $(55,838)$25,146 $80,830 $(52,493)$28,337 
(a)The increase in the gross carrying amount primarily reflects $500 million of capitalized Comirnaty sales milestones to BioNTech, partially offset by net losses from foreign currency translation adjustments.
(b)The decrease is primarily due to amortization, partially offset by the capitalization of the Comirnaty milestones described above.
Developed Technology Rights

Developed technology rights represent the cost for developed technology acquired from third parties and can include the right to develop, use, market, sell and/or offer for sale the product, compounds and intellectual property that we have acquired with respect to products, compounds and/or processes that have been completed. We possess a well-diversified portfolio of hundreds of developed technology rights across therapeutic categories, representing our commercialized products. The significant components of developed technology rights are the following: Xtandi, Prevnar 13/Prevenar 13 Infant, Braftovi/Mektovi, Premarin, Prevnar 13/Prevenar 13 Adult, Eucrisa, Orgovyx, Zavicefta, Tygacil, Bavencio, Merrem/Meronem and Comirnaty. Also included in this category are the post-approval milestone payments made under our alliance agreements for certain prescription pharmaceutical products.
Brands

Brands represent the cost for tradenames and know-how, as the products themselves do not receive patent protection. Indefinite-lived brands include Medrol and Depo-Medrol, while finite-lived brands include Zavedos and Depo-Provera.
IPR&D

IPR&D assets represent R&D assets that have not yet received regulatory approval in a major market. The significant components of IPR&D are the following: the program for the oral poly adenosine diphosphate (ADP) ribose polymerase inhibitor for the treatment of patients with germline BRCA-mutated advanced breast cancer acquired as part of the Medivation acquisition and assets acquired in connection with the Array acquisition. IPR&D assets are required to be classified as indefinite-lived assets until the successful completion or the abandonment of the associated R&D effort. Accordingly, during the development period after the date of acquisition, these assets are not amortized until approval is obtained in a major market, typically either the U.S. or the EU, or in a series of other countries, subject to certain specified conditions and management judgment. At that time, we will determine the useful life of the asset, reclassify it out of IPR&D and begin amortization. If the associated R&D effort is abandoned, the related IPR&D assets will likely be written-off, and we will record an impairment charge.

IPR&D assets are high-risk assets, given the uncertain nature of R&D. Accordingly, we expect that many of these IPR&D assets will become impaired and be written-off at some time in the future.
Licensing Agreements

Licensing agreements for developed technology and for technology in development primarily relate to out-licensing arrangements acquired from third parties, including the Array acquisition. These assets represent the cost for the license, where we acquired the right to future royalties and/or milestones upon development or commercialization by the licensing partner. A significant component of the licensing arrangements are for out-licensing arrangements with a number of partners for oncology technology in varying stages of development that have not yet received regulatory approval in a major market. Accordingly, during the development period after the date of acquisition, each of these assets is classified as indefinite-lived intangible assets and will not be amortized until approval is obtained in a major market. At that time we will determine the useful life of the asset, reclassify the respective licensing arrangement asset to finite-lived intangible asset and begin amortization. If the development effort is abandoned, the related licensing asset will likely be written-off, and we will record an impairment charge.
Amortization

The weighted-average life for each of our total finite-lived intangible assets is approximately 8 years, and for the largest component, developed technology rights, is approximately 7 years. Total amortization expense for finite-lived intangible assets was $3.7 billion in 2021, $3.4 billion in 2020 and $4.5 billion in 2019.
The following provides the expected annual amortization expense:
(MILLIONS)20222023202420252026
Amortization expense$3,279 $2,936 $2,686 $2,500 $2,449 
B. Goodwill
The following summarizes the components and changes in the carrying amount of Goodwill:
(MILLIONS)
Total(a)
Balance, January 1, 2020
$48,181 
Additions(b)
727 
Other(c)
648 
Balance, December 31, 2020
49,556 
Additions— 
Other(c)
(348)
Balance, December 31, 2021
$49,208 
(a)As a result of the reorganization of our commercial operations during the fourth quarter of 2021 (see Note 17), we were required to estimate the relative fair values of our PC1 and Hospital organizations to determine any reallocation of goodwill. We completed this analysis and determined that no goodwill was required to be reallocated. As a result, our entire goodwill balance continues to be assigned within the Biopharma reportable segment.
(b)Additions primarily represent the impact of measurement period adjustments related to our Array acquisition (see Note 2A).
(c)Other represents the impact of foreign exchange.
v3.22.0.1
Pension and Postretirement Benefit Plans and Defined Contribution Plans
 12 Months Ended
Dec. 31, 2021
Retirement Benefits [Abstract]  
Pension and Postretirement Benefit Plans and Defined Contribution Plans Pension and Postretirement Benefit Plans and Defined Contribution Plans
The majority of our employees worldwide are eligible for retirement benefits provided through defined benefit pension plans, defined contribution plans or both. In the U.S., we sponsor both IRC-qualified and supplemental (non-qualified) defined benefit plans and defined contribution plans. A qualified plan meets the requirements of certain sections of the IRC, and, generally, contributions to qualified plans are tax deductible. A qualified plan typically provides benefits to a broad group of employees with restrictions on discriminating in favor of highly compensated employees with regard to coverage, benefits and contributions. A supplemental (non-qualified) plan provides additional benefits to certain employees. In addition, we provide medical insurance benefits to certain retirees and their eligible dependents through our postretirement plans.

As discussed in Note 1C, we adopted a change in accounting principle to a more preferable policy under U.S. GAAP to immediately recognize actuarial gains and losses arising from the remeasurement of pension and postretirement plans. This change has been applied to all pension and postretirement plans on a retrospective basis for all prior periods presented.

A. Components of Net Periodic Benefit Costs and Changes in Other Comprehensive Income/(Loss)
The following summarizes the components of net periodic benefit cost/(credit), including those reported as part of discontinued operations for 2020 and 2019, and the changes in Other comprehensive income/(loss) for our benefit plans:
Pension Plans Postretirement Plans
U.S.International
Year Ended December 31,
(MILLIONS)202120202019202120202019202120202019
Service cost$— $— $— $130 $146 $125 $36 $38 $37 
Interest cost455 533 676 146 164 215 29 49 75 
Expected return on plan assets
(1,052)(1,015)(890)(327)(314)(318)(39)(36)(33)
Amortization of prior service cost/(credit)(2)(3)(4)(1)(3)(4)(151)(170)(173)
Actuarial (gains)/losses(a)
(684)1,152 284 (690)148 669 (167)(165)(118)
Curtailments— — (4)(4)— (1)(82)— (62)
Special termination benefits
17 1 20 — — — 2 — 2 
Net periodic benefit cost/(credit) reported in income(1,265)668 82 (746)141 686 (372)(282)(271)
Cost/(credit) reported in Other comprehensive income/(loss)
2 5 4 4 5 21 107 114 164 
Cost/(credit) recognized in Comprehensive income
$(1,264)$674 $86 $(742)$145 $707 $(265)$(168)$(107)
(a)Reflects actuarial remeasurement gains in 2021, primarily due to favorable plan asset performance and increases in discount rates, and actuarial remeasurement losses in 2020 and 2019, primarily due to decreases in discount rates partially offset by favorable plan asset performance.
The components of net periodic benefit cost/(credit) other than the service cost component are included in Other (income)/deductions––net (see Note 4).
B. Actuarial Assumptions
Pension PlansPostretirement Plans
U.S.International
Year Ended December 31,
(PERCENTAGES)202120202019202120202019202120202019
Weighted-average assumptions used to determine net periodic benefit cost:
Discount rate:
Pension plans/postretirement plans2.6 %3.3 %4.4 %2.5 %3.2 %4.3 %
Interest cost1.2 %1.5 %2.2 %
Service cost1.4 %1.6 %2.4 %
Expected return on plan assets6.8 %7.0 %7.2 %3.4 %3.6 %3.9 %6.8 %7.0 %7.3 %
Rate of compensation increase(a)
2.9 %2.9 %1.4 %
Weighted-average assumptions used to determine benefit obligations at fiscal year-end:
Discount rate2.9 %2.6 %3.3 %1.6 %1.5 %1.7 %2.9 %2.5 %3.2 %
Rate of compensation increase(a)
2.8 %2.9 %1.4 %
(a)The rate of compensation increase is not used to determine the net periodic benefit cost and benefit obligation for the U.S. pension plans as these plans are frozen.
All of the assumptions are reviewed on at least an annual basis. We revise these assumptions based on an annual evaluation of long-term trends as well as market conditions that may have an impact on the cost of providing retirement benefits.
The weighted-average discount rate for our U.S. defined benefit plans is determined annually and evaluated and modified to reflect at year-end the prevailing market rate of a portfolio of high-quality fixed income investments, rated AA/Aa or better that reflect the rates at which the pension benefits could be effectively settled. For our international plans, the discount rates are set by benchmarking against investment grade corporate bonds rated AA/Aa or better, including, when there is sufficient data, a yield curve approach. These rate determinations are made consistent with local requirements. Overall, the yield curves used to measure the benefit obligations at year-end 2021 resulted in higher discount rates as compared to the prior year.
The following provides the healthcare cost trend rate assumptions for our U.S. postretirement benefit plans:
As of December 31,
20212020
Healthcare cost trend rate assumed for next year 6.0 %5.6 %
Rate to which the cost trend rate is assumed to decline4.0 %4.5 %
Year that the rate reaches the ultimate trend rate2045 2037 
C. Obligations and Funded Status
The following provides: (i) an analysis of the changes in our benefit obligations, plan assets and funded status of our benefit plans, including those reported as part of discontinued operations for 2020, (ii) the funded status recognized in our consolidated balance sheets and (iii) the pre-tax components of cumulative amounts recognized in Accumulated other comprehensive loss:
 Pension Plans Postretirement Plans
 U.S. International
Year Ended December 31,
(MILLIONS)202120202021202020212020
Change in benefit obligation(a)
Benefit obligation, beginning$18,306 $17,886 $12,001 $11,059 $1,238 $1,667 
Service cost— — 130 146 36 38 
Interest cost455 533 146 164 29 49 
Employee contributions— — 10 8 78 88 
Plan amendments— 2 — 2 (116)(56)
Changes in actuarial assumptions and other(b)
(331)2,112 89 702 (117)(132)
Foreign exchange impact— — (298)646 1 2 
Upjohn spin-off(c)
— (1,016)3 (320)— (218)
Acquisitions/divestitures/other, net— — — — — — 
Curtailments and special termination benefits17 1 (2)— (8)— 
Settlements(785)(767)(47)(34)— — 
Benefits paid(512)(445)(374)(372)(147)(201)
Benefit obligation, ending(a)
17,150 18,306 11,657 12,001 995 1,238 
Change in plan assets
Fair value of plan assets, beginning
16,094 14,586 9,811 8,956 588 519 
Actual return on plan assets1,405 1,974 1,106 868 89 69 
Company contributions143 1,433 451 197 145 113 
Employee contributions— — 10 8 78 88 
Foreign exchange impact— — (229)462 — — 
Upjohn spin-off(c)
— (687)2 (270)— — 
Acquisitions/divestitures, net— — — (6)— — 
Settlements(785)(767)(47)(34)— — 
Benefits paid(512)(445)(374)(372)(147)(201)
Fair value of plan assets, ending16,346 16,094 10,729 9,811 753 588 
Funded status—Plan assets less than benefit obligation
$(805)$(2,211)$(928)$(2,191)$(241)$(651)
Amounts recorded in our consolidated balance sheet:
Noncurrent assets$447 $— $1,480 $522 $— $— 
Current liabilities(138)(127)(33)(31)(6)(6)
Noncurrent liabilities(1,113)(2,084)(2,376)(2,681)(235)(645)
Funded status$(805)$(2,211)$(928)$(2,191)$(241)$(651)
Pre-tax components of cumulative amounts recognized in Accumulated other comprehensive loss:
Prior service (costs)/credits$(6)$(4)$(35)$(31)$581 $688 
Information related to the funded status of pension plans with an ABO in excess of plan assets(d):
Fair value of plan assets
$120 $16,094 $1,304 $6,674 
ABO1,371 18,306 3,344 8,961 
Information related to the funded status of pension plans with a PBO in excess of plan assets(d):
Fair value of plan assets$120 $16,094 $1,381 $6,735 
PBO1,371 18,306 3,789 9,447 
(a)For the U.S. pension plans, the benefit obligation is both the PBO and ABO as these plans are frozen and future benefit accruals no longer increase with future compensation increases. For the international pension plans, the benefit obligation is the PBO. The ABO for our international pension plans was $11.2 billion in 2021 and $11.5 billion in 2020. For the postretirement plans, the benefit obligation is the ABO.
(b)Primarily includes actuarial gains resulting from increases in discount rates in 2021, offset by increases in inflation assumptions in 2021 for the international plans, and actuarial losses resulting from decreases in discount rates in 2020.
(c)For more information, see Note 2B.
(d)Our main U.S. qualified plan and many of our international plans were overfunded as of December 31, 2021.
D. Plan Assets
The following provides the components of plan assets, including those reported as part of discontinued operations for 2020:
As of December 31, 2021As of December 31, 2020
    Fair ValueFair Value
(MILLIONS EXCEPT TARGET ALLOCATION PERCENTAGE)Target Allocation PercentageTotalLevel 1Level
2		Level 3
Assets Measured at NAV(a)
TotalLevel 1Level
 2		Level 3
Assets Measured at NAV(a)
U.S. pension plans
Cash and cash equivalents0-10%$1,326 $78 $1,248 $— $— $781 $70 $711 $— $— 
Equity securities:20-40%
Global equity securities2,273 2,233 38 2 — 3,241 3,213 27 1 — 
Equity commingled funds1,352 — 1,152 — 200 1,325 — 1,110 — 215 
Fixed income securities:45-75%
Corporate debt securities5,566 18 5,548 — — 6,499 23 6,476 — — 
Government and agency obligations(b)
2,533 — 2,533 — — 1,555 — 1,555 — — 
Fixed income commingled funds38 — 38 — — 23 — 23 — — 
Other investments:5-20%
Partnership investments(c)
2,079 3 — — 2,076 1,431 — — — 1,431 
Insurance contracts158 — 158 — — 190 — 190 — — 
Other commingled funds(d)
1,019 — 10 — 1,009 1,049 — 11 — 1,038 
Total100 %$16,346 $2,332 $10,726 $2 $3,286 $16,094 $3,306 $10,103 $1 $2,684 
International pension plans
Cash and cash equivalents0-10%$541 $191 $346 $— $3 $407 $61 $346 $— $— 
Equity securities:10-20%
Equity commingled funds1,453 — 1,386 — 67 2,051 — 1,681 — 370 
Fixed income securities:45-70%
Corporate debt securities1,187 — 1,187 — — 925 — 925 — — 
Government and agency obligations(b)
2,415 — 2,415 — — 1,334 — 1,334 — — 
Fixed income commingled funds2,266 — 1,138 — 1,128 2,484 — 1,217 — 1,267 
Other investments:15-35%
Partnership investments(c)
107 — 2 — 106 69 — 3 — 66 
Insurance contracts1,329 — 56 1,273 — 1,027 — 57 969 1 
Other(d)
1,431 — 141 404 886 1,514 — 117 393 1,003 
Total100 %$10,729 $191 $6,672 $1,677 $2,189 $9,811 $61 $5,681 $1,362 $2,707 
U.S. postretirement plans(e)
Cash and cash equivalents0-5%$85 $3 $82 $— $— $— $— $— $— $— 
Insurance contracts95-100%669 — 669 — — 588 — 588 — — 
Total100 %$753 $3 $750 $— $— $588 $— $588 $— $— 
(a)Certain investments that are measured at NAV per share (or its equivalent) have not been classified in the fair value hierarchy. The NAV amounts presented in this table are intended to permit reconciliation of the fair value hierarchy to the amounts presented for the total pension benefits plan assets.
(b)Government and agency obligations are inclusive of repurchase agreements.
(c)Mainly includes investments in private equity, private debt, public equity limited partnerships, and, to a lesser extent, real estate and venture capital.
(d)Mostly includes investments in hedge funds and real estate.
(e)Reflects postretirement plan assets, which support a portion of our U.S. retiree medical plans.
The following provides an analysis of the changes in our more significant investments valued using significant unobservable inputs, including those reported as part of discontinued operations for 2020:
International Pension Plans
Year Ended December 31,
(MILLIONS)20212020
Fair value, beginning$1,362 $1,342 
Actual return on plan assets:
Assets held, ending23 22 
Purchases, sales, and settlements, net
52 (47)
Transfer into/(out of) Level 3265 (13)
Exchange rate changes(24)58 
Fair value, ending$1,677 $1,362 
The following methods and assumptions were used to estimate the fair value of our pension and postretirement plans’ assets:
•Cash and cash equivalents: Level 1 investments may include cash, cash equivalents and foreign currency valued using exchange rates. Level 2 investments may include short-term investment funds which are commingled funds priced at a stable NAV by the administrator of the funds.
•Equity securities: Level 1 investments may include individual securities that are valued at the closing price or last trade reported on the major market on which they are traded. Level 1 and Level 2 investments may include commingled funds that have a readily determinable fair value based on quoted prices on an exchange or a published NAV derived from the quoted prices in active markets of the underlying securities. Level 3 investments may include individual securities that are unlisted, delisted, suspended, or illiquid and are typically valued using their last available price.
•Fixed income securities: Level 1 investments may include individual securities that are valued at the closing price or last trade reported on the major market on which they are traded. Level 2 investments may include commingled funds that have a readily determinable fair value based on observable prices of the underlying securities. Level 2 investments may include corporate bonds, government and government agency obligations and other fixed income securities valued using bid evaluation pricing models or quoted prices of securities with similar characteristics. Level 3 investments may include securities that are valued using alternative pricing sources, such as investment managers or brokers, which use proprietary pricing models that incorporate unobservable inputs.
•Other investments: Level 1 investments may include individual securities that are valued at the closing price or last trade reported on the major market on which they are traded. Level 2 investments may include Insurance contracts which invest in interest bearing cash, U.S. government securities and corporate debt instruments. Level 3 investments may include securities or insurance contracts that are valued using alternative pricing sources, such as investment managers or brokers, which use proprietary pricing models that incorporate unobservable inputs.
Equity securities, Fixed income securities and Other investments may each be combined into commingled funds. Most commingled funds are valued to reflect the interest in the fund based on the reported year-end NAV. Partnership and Other investments are valued based on year-end reported NAV (or its equivalent), with adjustments as appropriate for lagged reporting of up to three months.
Certain investments are authorized to include derivatives, such as equity or bond futures, swaps, options and currency futures or forwards for managing risks and exposures.
Global plan assets are managed with the objective of generating returns that will enable the plans to meet their future obligations, while seeking to manage net periodic benefit costs and cash contributions over the long-term. We utilize long-term asset allocation ranges in the management of our plans’ invested assets. Our long-term return expectations are developed based on a diversified, global investment strategy that takes into account historical experience, as well as the impact of portfolio diversification, active portfolio management, and our view of current and future economic and financial market conditions. As market conditions and other factors change, we may adjust our targets accordingly and our asset allocations may vary from the target allocations.

E. Cash Flows

It is our practice to fund amounts for our qualified pension plans that are at least sufficient to meet the minimum requirements set forth in applicable employee benefit laws and local tax laws.
The following provides the expected future cash flow information related to our benefit plans:
  Pension PlansPostretirement Plans
(MILLIONS)U.S.International
Expected employer contributions:
2022$138 $177 $74 
Expected benefit payments:
2022$1,296 $384 $78 
20231,155 372 73 
20241,140 383 69 
20251,089 392 66 
20261,058 397 68 
2027–20314,908 2,124 359 
The above table reflects the total U.S. and international plan benefits projected to be paid from the plans or from our general assets under the current actuarial assumptions used for the calculation of the benefit obligation.
F. Defined Contribution Plans
We have defined contribution plans in the U.S. and other countries. For the majority of the U.S. defined contribution plans, employees may contribute a portion of their salaries and bonuses to the plans, and we match, in cash, a portion of the employee contributions. We also offer a Retirement Savings Contribution (RSC) which is an annual non-contributory employer contribution in the U.S. and Puerto Rico. We recorded charges related to the employer contributions to global defined contribution plans of $732 million in 2021, $685 million in 2020 and $659 million in 2019.
v3.22.0.1
Equity
 12 Months Ended
Dec. 31, 2021
Equity [Abstract]  
Equity Equity
A. Common Stock Purchases

We purchase our common stock through privately negotiated transactions or in the open market as circumstances and prices warrant. Purchased shares under each of the share-purchase plans, which are authorized by our BOD, are available for general corporate purposes. In December 2017, the BOD authorized a $10 billion share repurchase program, which was exhausted in the first quarter of 2019. In December 2018, the BOD authorized another $10 billion share repurchase program to be utilized over time and share repurchases commenced thereunder in the first quarter of 2019.
In February 2019, we entered into an ASR with Goldman Sachs & Co. LLC to repurchase $6.8 billion of our common stock pursuant to our previously announced share repurchase authorization. We paid $6.8 billion and received an initial delivery of 130 million shares of common stock, which represented approximately 80% of the notional amount of the ASR. In August 2019, the ASR with Goldman Sachs & Co. LLC was completed resulting in Goldman Sachs & Co. LLC owing us an additional 33.5 million shares of our common stock. The average price paid for all of the shares delivered under the ASR was $41.42 per share. The common stock received is included in Treasury stock.
The following provides the number of shares of our common stock purchased and the cost of purchases under our publicly announced share purchase plans, including our ASR:
Year Ended December 31,
(SHARES IN MILLIONS, DOLLARS IN BILLIONS)
2021
2020
2019(a)
Shares of common stock purchased— — 213 
Cost of purchase$— $— $8.9 
(a)Represents shares purchased pursuant to the ASR with Goldman Sachs & Co. LLC entered into in February 2019, as well as open market share repurchases of $2.1 billion.
Our remaining share-purchase authorization was approximately $5.3 billion at December 31, 2021.
B. Preferred Stock and Employee Stock Ownership Plans

Prior to May 4, 2020, we had outstanding Series A convertible perpetual preferred stock (the Series A Preferred Stock) that was held by an ESOP trust (the Trust). All outstanding shares of Series A Preferred Stock were converted, at the direction of the independent fiduciary under the Trust and in accordance with the certificate of designations for the Series A Preferred Stock, into shares of our common stock on May 4, 2020. The Trust received an aggregate of 1,070,369 shares of our common stock upon conversion, with zero shares of Series A Preferred Stock remaining outstanding as a result of the conversion. In December 2020, we filed a certificate of elimination and a restated certificate of incorporation with the Delaware Secretary of State, which eliminated the Series A Preferred Stock.

Since May 4, 2020, we have one ESOP that holds common stock of the Company (Common ESOP). As of December 31, 2021, all shares of common stock held by the Common ESOP have been allocated to the Pfizer U.S. defined contribution plan participants. The compensation cost related to the Common ESOP was $19 million in 2021, $19 million in 2020 and $20 million in 2019.
v3.22.0.1
Share-Based Payments
 12 Months Ended
Dec. 31, 2021
Share-based Payment Arrangement [Abstract]  
Share-Based Payments Share-Based Payments
Our compensation programs can include share-based payment awards with value that is determined by reference to the fair value of our shares and that provide for the grant of shares or options to acquire shares or similar arrangements. Our share-based awards are designed based on competitive survey data or industry peer groups used for compensation purposes, and are allocated between different long-term incentive awards, generally in the form of Total Shareholder Return Units (TSRUs), Restricted Stock Units (RSUs), Portfolio Performance Shares (PPSs), Performance Share Awards (PSAs), Breakthrough Performance Awards (BPAs) and Stock Options, as determined by the Compensation Committee.

The 2019 Stock Plan (2019 Plan) replaced and superseded the 2014 Plan. It provides for 400 million shares, in addition to shares remaining under the 2014 Plan, to be authorized for grants. The 2019 Plan provides that the number of stock options, TSRUs, RSUs, or performance-based awards that may be granted to any one individual during any 36-month period is limited to 20 million shares, and that RSUs count as three shares, PPSs, PSAs and BPAs count as three shares times the maximum potential payout, while TSRUs and stock options count as one share, toward the maximum shares available under the 2019 Plan. As of December 31, 2021, 315 million shares were available for award. Although not required to do so, we have used authorized and unissued shares and, to a lesser extent, treasury stock to satisfy our obligations under these programs.
A summary of the awards and valuation details:
Awarded toTermsValuationRecognition and Presentation
Total Shareholder Return Units (TSRUs)(a), (b)
Senior and other key management and select employees
•Entitle the holder to receive shares of our common stock with a value equal to the difference between the defined settlement price and the grant price, plus the dividend equivalents accumulated during the five or seven-year term, if and to the extent the total value is positive.
•Settlement price is the average closing price of our common stock during the 20 trading days ending on the fifth or seventh anniversary of the grant, as applicable; the grant price is the closing price of our common stock on the date of the grant.
•Automatically settle on the fifth or seventh anniversary of the grant but vest on the third anniversary of the grant.
As of the grant date using a Monte Carlo simulation model
Amortized on a straight-line basis over the vesting term into Cost of sales, Selling, informational and administrative expenses, and/or Research and development expenses, as appropriate.
Restricted Stock Units (RSUs)
Select employees
•Entitle the holder to receive a specified number of shares of our common stock, including dividend equivalents that are reinvested into additional RSUs.
•For RSUs granted, in virtually all instances, the units vest on the third anniversary of the grant date assuming continuous service from the grant date.
As of the grant date using the closing price of our common stock
Amortized on a straight-line basis over the vesting term into Cost of sales, Selling, informational and administrative expenses, and/or Research and development expenses, as appropriate.
Portfolio Performance Shares (PPSs)
Select employees
•Entitle the holder to receive, at the end of the performance period, shares of our common stock, if any, including shares resulting from dividend equivalents earned on such shares.
•For PPSs granted, the awards vest on the third anniversary of the grant assuming continuous service from the grant date and the number of shares paid, if any, depends on the achievement of predetermined goals related to Pfizer’s long-term product portfolio during a three or five-year performance period from the year of the grant date, as applicable.
•The number of shares that may be earned ranges from 0% to 200% of the initial award depending on goal achievement over the performance period.
As of the grant date using the intrinsic value method using the closing price of our common stock
Amortized on a straight-line basis over the vesting term into Cost of sales, Selling, informational and administrative expenses and/or Research and development expenses, as appropriate, and adjusted each reporting period, as necessary, to reflect changes in the price of our common stock, the number of shares that are probable of being earned, and management’s assessment of the probability that the specified performance criteria will be achieved.
Performance Share Awards (PSAs)
Senior and other key management
•Entitle the holder to receive, at the end of the performance period, shares of our common stock (retirees) earned, if any, or an equal value in cash (active colleagues), including dividend equivalents on shares earned, dependent upon the achievement of predetermined goals related to two measures:
a.Adjusted net income over three one-year periods; and
b.TSR as compared to the NYSE ARCA Pharmaceutical Index (DRG Index) over the three-year performance period.
•PSAs vest on the third anniversary of the grant assuming continuous service from the grant date.
•The award that may be earned ranges from 0% to 200% of the target award depending on goal achievement over the performance period.
As of the grant date using the intrinsic value method using the closing price of our common stock
Amortized on a straight-line basis over the vesting term into Cost of sales, Selling, informational and administrative expenses, and/or Research and development expenses, as appropriate, and adjusted each reporting period, as necessary, to reflect changes in the price of our common stock, the number of shares that are probable of being earned and management’s assessment of the probability that the specified performance criteria will be achieved.
Breakthrough Performance Awards (BPAs)
Select employees identified as instrumental in delivering medicines to patients (excluding executive officers)
•Entitle the holder to receive, at the end of the performance period, shares of our common stock, if any, including shares resulting from dividend equivalents earned on such shares.
•For BPAs granted, the awards, if earned/vested, are settled at the end of the performance period, but no earlier than the one-year anniversary of the date of grant and dependent upon the achievement of the respective predetermined performance goals related to advancing Pfizer’s product pipeline during the performance period.
•The number of shares that may be earned ranges from 0% to 600% of the target award depending on the level and timing of goal achievement over the performance period.
As of the grant date using the intrinsic value method using the closing price of our common stock
Amortized on a straight-line basis over the probable vesting term into Cost of sales, Selling, informational and administrative expenses, and/or Research and development expenses, as appropriate, and adjusted each reporting period, as necessary, to reflect changes in the price of our common stock, the number of shares that are probable of being earned and management’s assessment of the probability that the specified performance criteria will be achieved and/or management’s assessment of the probable vesting term.
Awarded toTermsValuationRecognition and Presentation
Stock Options
Select employees
•Entitle the holder to purchase a specified number of shares of our common stock at a price per share equal to the closing market price of our common stock on the date of grant, for a period of time when vested.
•Since 2016, only a limited set of non-U.S. employees received stock option grants. No stock options were awarded to senior and other key management in any period presented.
•Stock options vest on the third anniversary of the grant assuming continuous service from the grant date and have a contractual term of 10 years.
As of the grant date using the Black-Scholes-Merton option-pricing model
Amortized on a straight-line basis over the vesting term into Cost of sales, Selling, informational and administrative expenses, and/or Research and development expenses, as appropriate.
(a)Retirement-eligible holders, as defined in the grant terms, can convert their TSRUs, when vested, into Profit Units (PTUs) with a conversion ratio based on a calculation used to determine the shares at TSRU settlement. The PTUs are entitled to earn Dividend Equivalent Units (DEUs), and the PTUs and DEUs will be settled in our common stock on the TSRUs’ original settlement date and will be subject to the terms and conditions of the original grant including forfeiture provisions.
(b)In 2017, Performance Total Shareholder Return Units (PTSRUs) were awarded to the Former Chairman and Chief Executive Officer (1,444,395 PTSRUs) and 361,099 PTSRUs were awarded to the Group President, Chief Business Officer (former role Group President Pfizer Innovative Health) at a grant price of $30.31 and at a GDFV of $5.54 per PTSRU. In addition to having the same characteristics and valuation methodology of TSRUs, PTSRU grants require special service and performance conditions.
The following provides data related to all TSRU, RSU, PPS, PSA and stock option activity:
(MILLIONS, EXCEPT FAIR VALUE OF SHARES VESTED PER TSRU AND STOCK OPTION)TSRUsRSUsPPSsPSAsStock Options
Year Ended December 31,202120202019202120202019202120202019202120202019202120202019
Total fair value of shares vested(a)
$7.26$6.22$8.52$304$334$454$181$119$136$33$25$64$4.86$3.56$5.98
Total intrinsic value of options exercised or share units converted$594$84$175$228$224$245$584$293$261
Cash received upon exercise$795$425$394
Tax benefits realized from exercise$106$55$47
Compensation cost recognized, pre-tax(b)
$259$287$294$281$272$275$535$180$114$76$31$28$5$6$7
Total compensation cost related to nonvested awards not yet recognized, pre-tax$187$224$229$271$228$241$175$104$87$54$32$34$3$4$5
Weighted-average period over which cost is expected to be recognized (years)1.61.61.61.81.71.71.81.81.81.81.91.81.61.71.6
(a)Weighted-average GDFV per TSRUs and stock options.
(b)TSRU includes expense for PTSRUs, which is not significant for all years presented.
Total share-based payment expense was $1.2 billion, $780 million and $718 million in 2021, 2020 and 2019, respectively, which includes pre-tax share-based payment expense included in Discontinued operations––net of tax of $2 million, $25 million and $32 million in 2021, 2020 and 2019, respectively. Tax benefit for share-based compensation expense was $227 million, $141 million and $137 million in 2021, 2020 and 2019, respectively.
The table above excludes total expense due to the modification for share-based awards in connection with our cost reduction/productivity initiatives, which was not significant for all years presented and is recorded in Restructuring charges and certain acquisition-related costs (see Note 3). Amounts capitalized as part of inventory cost were not significant for any period presented.
Summary of the weighted-average assumptions used in the valuation of TSRUs and stock options:
TSRUsStock Options
Year Ended December 31,202120202019202120202019
Expected dividend yield (based on a constant dividend yield during the expected term)
4.51 %4.36 %3.27 %4.51 %4.36 %3.27 %
Risk-free interest rate (based on interpolated yield on U.S. Treasury zero-coupon issues)
0.93 %1.15 %2.55 %1.27 %1.25 %2.66 %
Expected stock price volatility (based on implied volatility, after consideration of historical volatility)
26.53 %20.99 %18.34 %26.54 %20.97 %18.34 %
TSRUs contractual/stock options expected term, years (based on historical exercise and post-vesting termination patterns for stock options)
5.155.125.136.756.756.75
Summary of all TSRU, RSU, PPS, PSA and BPA activity during 2021 (with the shares granted representing the maximum award that could be achieved for PPSs, PSAs and BPAs):
TSRUsRSUs
PPSs(a)
PSAsBPAs
TSRUs Per TSRU, Weighted AverageShares  Weighted Avg. GDFV per shareShares Weighted Avg. Intrinsic Value per shareShares Weighted Avg. Intrinsic Value per shareShares Weighted Avg. Intrinsic Value per share
(Thousands)GDFVGrant Price(Thousands)(Thousands)(Thousands)(Thousands)
Nonvested,
December 31, 2020
129,844$6.90 $32.94 23,692$35.50 20,077$36.81 5,264$36.81 — $— 
Granted34,5227.26 33.83 10,89334.31 8,63233.82 1,79833.82 1,16538.73 
Vested(44,888)7.21 30.54 (8,747)34.66 (6,095)33.88 (984)33.85 — — 
Reinvested dividend equivalents956 41.33 
Forfeited(4,879)6.77 33.78 (1,255)35.17 (1,133)41.45 (924)34.43 (306)47.47 
Nonvested, December 31, 2021
114,599$6.90 $34.12 25,540$35.52 21,480$59.05 5,154$59.05 859$59.05 
(a)Vested and non-vested shares outstanding, but not paid as of December 31, 2021 were 34.1 million.
Summary of TSRU and PTU information as of December 31, 2021(a), (b):
TSRUs
(Thousands)
PTUs
(Thousands)
Weighted-Average
Grant Price
Per TSRU
Weighted-Average
Remaining Contractual Term (Years)
Aggregate Intrinsic Value (Millions)
TSRUs Outstanding206,996 — $31.71 2.2$5,969 
TSRUs Vested92,398 — 28.72 0.82,946 
TSRUs Expected to vest(c)
110,476 — 34.16 3.32,910 
TSRUs exercised and converted to PTUs— 3,074 $— 0.8$182 
(a)In 2021, we settled 46,060,346 TSRUs with a weighted-average grant price of $23.04 per unit.
(b)In 2021, 7,093,787 TSRUs with a weighted-average grant price of $27.41 per unit were converted into 2,943,737 PTUs.
(c)The number of TSRUs expected to vest takes into account an estimate of expected forfeitures.
Summary of all stock option activity during 2021:
Shares
(Thousands)
Weighted-Average
Exercise Price
Per Share
Weighted-Average
Remaining Contractual Term
(Years)
Aggregate
Intrinsic Value(a)
(Millions)
Outstanding, December 31, 2020
75,402 $28.31 
Granted779 33.82 
Exercised(31,036)25.75 
Forfeited(89)34.39 
Expired(181)20.27   
Outstanding, December 31, 2021
44,874 30.20 2.7$1,295 
Vested and expected to vest, December 31, 2021(b)
44,747 30.19 2.71,291 
Exercisable, December 31, 2021
41,583 $29.81 2.3$1,216 
(a)Market price of our underlying common stock less exercise price.
(b)The number of options expected to vest takes into account an estimate of expected forfeitures.
v3.22.0.1
Earnings Per Common Share Attributable to Pfizer Inc. Common Shareholders
 12 Months Ended
Dec. 31, 2021
Earnings Per Share [Abstract]  
Earnings Per Common Share Attributable to Pfizer Inc. Common Shareholders Earnings Per Common Share Attributable to Pfizer Inc. Common Shareholders
The following presents the detailed calculation of EPS:
 Year Ended December 31,
(IN MILLIONS)202120202019
EPS Numerator––Basic  
Income from continuing operations attributable to Pfizer Inc.
$22,414 $6,630 $10,708 
Less: Preferred stock dividends––net of tax— — 1 
Income from continuing operations attributable to Pfizer Inc. common shareholders
22,414 6,630 10,708 
Discontinued operations––net of tax(434)2,529 5,318 
Net income attributable to Pfizer Inc. common shareholders
$21,979 $9,159 $16,025 
EPS Numerator––Diluted  
Income from continuing operations attributable to Pfizer Inc. common shareholders and assumed conversions
$22,414 $6,630 $10,708 
Discontinued operations––net of tax, attributable to Pfizer Inc. common shareholders and assumed conversions(434)2,529 5,318 
Net income attributable to Pfizer Inc. common shareholders and assumed conversions
$21,979 $9,159 $16,026 
EPS Denominator  
Weighted-average number of common shares outstanding––Basic5,601 5,555 5,569 
Common-share equivalents: stock options, stock issuable under employee compensation plans convertible preferred stock and accelerated share repurchase agreements107 77 106 
Weighted-average number of common shares outstanding––Diluted
5,708 5,632 5,675 
Anti-dilutive common stock equivalents(a)
2 4 2 
(a)These common stock equivalents were outstanding for the periods presented, but were not included in the computation of diluted EPS for those periods because their inclusion would have had an anti-dilutive effect.
Allocated shares held by the Common ESOP, including reinvested dividends, are considered outstanding for EPS calculations and the eventual conversion of allocated preferred shares held by the Preferred ESOP was assumed in the diluted EPS calculation until the conversion date, which occurred in May 2020. See Note 12.
v3.22.0.1
Leases
 12 Months Ended
Dec. 31, 2021
Leases [Abstract]  
Leases Leases
We lease real estate, fleet, and equipment for use in our operations. Our leases generally have lease terms of 1 to 30 years, some of which include options to terminate or extend leases for up to 5 to 10 years or on a month-to-month basis. We include options that are reasonably certain to be exercised as part of the determination of lease terms. We may negotiate termination clauses in anticipation of any changes in market conditions, but generally these termination options have not been exercised. Residual value guarantees are generally not included within our operating leases with the exception of some fleet leases. In addition to base rent payments, the leases may require us to pay directly for taxes and other non-lease components, such as insurance, maintenance and other operating expenses, which may be dependent on usage or vary month-to-month. Variable lease payments amounted to $381 million in 2021, $380 million in 2020 and $326 million in 2019. We elected the practical expedient to not separate non-lease components from lease components in calculating the amounts of ROU assets and lease liabilities for all underlying asset classes.
We determine if an arrangement is a lease at inception of the contract and we perform the lease classification test as of the lease commencement date. ROU assets represent our right to use an underlying asset for the lease term and lease liabilities represent our obligation to make lease payments arising from the lease. Operating lease ROU assets and liabilities are recognized at commencement date based on the present value of lease payments over the lease term. As most of our leases do not provide an implicit rate, we use our estimated incremental borrowing rate based on the information available at commencement date in determining the present value of future payments.
For operating leases, the ROU assets and liabilities in our consolidated balance sheets follows:
As of December 31,
(MILLIONS)Balance Sheet Classification20212020
ROU assetsOther noncurrent assets$2,839 $1,386 
Lease liabilities (short-term)Other current liabilities449 320 
Lease liabilities (long-term)Other noncurrent liabilities2,510 1,108 
Components of total lease cost includes:
Year Ended December 31,
(MILLIONS)202120202019
Operating lease cost$548 $432 $421 
Variable lease cost381 380 326 
Sublease income(41)(40)(45)
Total lease cost$888 $772 $702 
Other supplemental information follows:
As of December 31,
(MILLIONS)20212020
Operating leases
Weighted-Average Remaining Contractual Lease Term (Years)126.9
Weighted-Average Discount Rate2.8 %2.9 %
Year Ended December 31,
(MILLIONS)202120202019
Cash paid for amounts included in the measurement of lease liabilities:
Operating cash flows from operating leases$387 $333 $338 
(Gains)/losses on sale and leaseback transactions, net1 (3)(29)
The following reconciles the undiscounted cash flows for the first five years and total of the remaining years to the operating lease liabilities recorded in the consolidated balance sheet as of December 31, 2021:
(MILLIONS)
PeriodOperating Lease Liabilities
Next one year(a)
$520 
1-2 years417 
2-3 years322 
3-4 years279 
4-5 years217 
Thereafter1,865 
Total undiscounted lease payments3,621 
Less: Imputed interest
661 
Present value of minimum lease payments2,960 
Less: Current portion
449 
Noncurrent portion$2,510 
(a)Reflects lease payments due within 12 months subsequent to the balance sheet date.
v3.22.0.1
Contingencies and Certain Commitments
 12 Months Ended
Dec. 31, 2021
Commitments and Contingencies Disclosure [Abstract]  
Contingencies and Certain Commitments Contingencies and Certain Commitments
We and certain of our subsidiaries are subject to numerous contingencies arising in the ordinary course of business, including tax and legal contingencies. The following outlines our legal contingencies. For a discussion of our tax contingencies, see Note 5B.
A. Legal Proceedings
Our legal contingencies include, but are not limited to, the following:
•Patent litigation, which typically involves challenges to the coverage and/or validity of patents on various products, processes or dosage forms. An adverse outcome could result in loss of patent protection for a product, a significant loss of revenues from that product or impairment of the value of associated assets. We are the plaintiff in the majority of these actions.
•Product liability and other product-related litigation related to current or former products, which can include personal injury, consumer, off-label promotion, securities, antitrust and breach of contract claims, among others, and often involves highly complex issues relating to medical causation, label warnings and reliance on those warnings, scientific evidence and findings, actual, provable injury and other matters.
•Commercial and other asserted or unasserted matters, which can include acquisition-, licensing-, intellectual property-, collaboration- or co-promotion-related and product-pricing claims and environmental claims and proceedings, can involve complexities that will vary from matter to matter.
•Government investigations, which often are related to the extensive regulation of pharmaceutical companies by national, state and local government agencies in the U.S. and in other jurisdictions.
Certain of these contingencies could result in increased expenses and/or losses, including damages, royalty payments, fines and/or civil penalties, which could be substantial, and/or criminal charges.
We believe that our claims and defenses in matters in which we are a defendant are substantial, but litigation is inherently unpredictable and excessive verdicts do occur. We do not believe that any of these matters will have a material adverse effect on our financial position. However, we could incur judgments, enter into settlements or revise our expectations regarding the outcome of matters, which could have a material adverse effect on our results of operations and/or our cash flows in the period in which the amounts are accrued or paid.
We have accrued for losses that are both probable and reasonably estimable. Substantially all of our contingencies are subject to significant uncertainties and, therefore, determining the likelihood of a loss and/or the measurement of any loss can be complex. Consequently, we are unable to estimate the range of reasonably possible loss in excess of amounts accrued. Our assessments, which result from a complex series of judgments about future events and uncertainties, are based on estimates and assumptions that have been deemed reasonable by management, but that may prove to be incomplete or inaccurate, and unanticipated events and circumstances may occur that might cause us to change those estimates and assumptions.
Amounts recorded for legal and environmental contingencies can result from a complex series of judgments about future events and uncertainties and can rely heavily on estimates and assumptions. For proceedings under environmental laws to which a governmental authority is a party, we have adopted a disclosure threshold of $1 million in potential or actual governmental monetary sanctions.
The principal pending matters to which we are a party are discussed below. In determining whether a pending matter is a principal matter, we consider both quantitative and qualitative factors to assess materiality, such as, among others, the amount of damages and the nature of other relief sought, if specified; our view of the merits of the claims and of the strength of our defenses; whether the action purports to be, or is, a class action and, if not certified, our view of the likelihood that a class will be certified by the court; the jurisdiction in which the proceeding is pending; whether related actions have been transferred to multidistrict litigation; any experience that we or, to our knowledge, other companies have had in similar proceedings; whether disclosure of the action would be important to a reader of our financial statements, including whether disclosure might change a reader’s judgment about our financial statements in light of all of the information that is available to the reader; the potential impact of the proceeding on our reputation; and the extent of public interest in the matter. In addition, with respect to patent matters in which we are the plaintiff, we consider, among other things, the financial significance of the product protected by the patent(s) at issue. Some of the matters discussed below include those which management believes that the likelihood of possible loss in excess of amounts accrued is remote.
A1. Legal Proceedings––Patent Litigation
We are involved in suits relating to our patents, including but not limited to, those discussed below. Most involve claims by generic drug manufacturers that patents covering our products (or those of our collaboration/licensing partners to which we have licenses or co-promotion rights and to which we may or may not be a party), processes or dosage forms are invalid and/or do not cover the product of the generic drug manufacturer. Also, counterclaims, as well as various independent actions, have been filed alleging that our assertions of, or attempts to enforce, patent rights with respect to certain products constitute unfair competition and/or violations of antitrust laws. In addition to the challenges to the U.S. patents that are discussed below, patent rights to certain of our products or those of our collaboration/licensing partners are being challenged in various other jurisdictions. For example, some of our collaboration or licensing partners face challenges to the validity of their patent rights in non-U.S. jurisdictions. We are also party to patent damages suits in various jurisdictions pursuant to which generic drug manufacturers, payers, governments or other parties are seeking damages from us for allegedly causing delay of generic entry.

We also are often involved in other proceedings, such as inter partes review, post-grant review, re-examination or opposition proceedings, before the U.S. Patent and Trademark Office, the European Patent Office, or other foreign counterparts relating to our intellectual property or the intellectual property rights of others. Also, if one of our patents is found to be invalid by such proceedings, generic or competitive products could be introduced into the market resulting in the erosion of sales of our existing products. For example, several of the patents in our pneumococcal vaccine portfolio were challenged in inter partes review and post-grant review proceedings in the U.S. In 2017, the Patent Trial and Appeal Board (PTAB) initiated proceedings with respect to two of our pneumococcal vaccine patents. However, the PTAB declined to initiate proceedings as to two other pneumococcal vaccine patents; those two patents, and one other patent, were challenged in federal court in Delaware. In September 2021, Pfizer and a challenger entered into a settlement and license agreement, resolving all worldwide legal proceedings involving that challenger, related to our pneumococcal vaccine patents. Other challenges to pneumococcal vaccine patents remain pending at the PTAB and outside the U.S. The invalidation of any of the patents in our pneumococcal portfolio could potentially allow additional competitor vaccines into the marketplace. In the event that any of the patents are found valid and infringed, a competitor’s vaccine might be prohibited from entering the market or a competitor might be required to pay us a royalty.

We are also subject to patent litigation pursuant to which one or more third parties seek damages and/or injunctive relief to compensate for alleged infringement of its patents by our commercial or other activities. For example, our Hospira subsidiaries are involved in patent and patent-related disputes over their attempts to bring generic pharmaceutical and biosimilar products to market. If one of our marketed products is found to infringe valid patent rights of a third party, such third party may be awarded significant damages or royalty payments, or we may be prevented from further sales of that product. Such damages may be enhanced as much as three-fold if we or one of our subsidiaries is found to have willfully infringed valid patent rights of a third party.
Actions In Which We Are The Plaintiff
EpiPen
In 2010, King, which we acquired in 2011 and is a wholly-owned subsidiary, brought a patent-infringement action against Sandoz in the U.S. District Court for the District of New Jersey in connection with Sandoz’s abbreviated new drug application (ANDA) filed with the FDA seeking approval to market an epinephrine injectable product. Sandoz is challenging patents, which expire in 2025, covering the next-generation autoinjector for use with epinephrine that is sold under the EpiPen brand name.
Xeljanz (tofacitinib)
Beginning in 2017, we brought patent-infringement actions against several generic manufacturers that filed separate ANDAs with the FDA seeking approval to market their generic versions of tofacitinib tablets in one or both of 5 mg and 10 mg dosage strengths, and in both immediate and extended release forms. To date, we have settled actions with several manufacturers on terms not material to us. The remaining actions continue in the U.S. District Court for the District of Delaware as described below.
In January 2021, we brought a separate patent-infringement action against Aurobindo Pharma Limited (Aurobindo) asserting the infringement and validity of the patent covering the active ingredient expiring in December 2025 and the patent covering a polymorphic form of tofacitinib expiring in 2023, which Aurobindo challenged in its ANDA seeking approval to market a generic version of tofacitinib 5 mg and 10 mg tablets.
In October 2021, we brought a separate patent-infringement action against Sinotherapeutics Inc. (Sinotherapeutics) asserting the infringement and validity of our patent covering extended release formulations of tofacitinib that was challenged by Sinotherapeutics in its ANDA seeking approval to market a generic version of tofacitinib 11 mg extended release tablets.
In February 2022, we brought a separate patent-infringement action against Teva Pharmaceuticals USA, Inc. (Teva) asserting the infringement and validity of our patent covering extended release formulations of tofacitinib that was challenged by Teva in its ANDA seeking approval to market a generic version of tofacitinib 22 mg extended release tablets.
In February 2022, we brought a separate patent-infringement action against Slayback Pharma LLC (Slayback) asserting the infringement and validity of our compound patent covering the active ingredient that was challenged by Slayback in its ANDA seeking approval to market a generic version of tofacitinib oral solution 1 mg/mL.
Inlyta (axitinib)
In 2019, Glenmark Pharmaceuticals Ltd. (Glenmark) notified us that it had filed an ANDA with the FDA seeking approval to market a generic version of Inlyta. Glenmark asserts the invalidity and non-infringement of the crystalline form patent for Inlyta that expires in 2030. In 2019, we filed suit against Glenmark in the U.S. District Court for the District of Delaware, asserting the validity and infringement of the crystalline form patent for Inlyta.
Ibrance (palbociclib)
Beginning in September 2020, we received correspondence from several generic companies notifying us that they would seek approval to market generic versions of Ibrance capsules. The generic companies assert the invalidity and non-infringement of our crystalline form patent which expires in 2034. Beginning in October 2020, we brought patent infringement actions against each of these generic companies in various federal courts, asserting the validity and infringement of the crystalline form patent. We have settled with one of these generic companies on terms not material to the company.
Beginning in January 2021, several generic companies notified us that they had filed ANDAs with the FDA seeking approval to market generic versions of Ibrance tablets. The generic companies are challenging some or all of the following patents: (i) the composition of matter patent expiring in 2027; (ii) the composition of matter patent expiring in 2023; (iii) the method of use patent expiring in 2023; (iv) the crystalline form patent expiring in 2034; and (v) a tablet formulation patent expiring in 2036. We brought patent infringement actions against each of the generic filers in various federal courts, asserting the validity and infringement of the patents challenged by the generic companies.
Eucrisa
Beginning in September 2021, several generic companies notified us that they had filed ANDAs with the FDA seeking approval to market generic versions of Eucrisa. The companies assert the invalidity and non-infringement of a composition of matter patent expiring in 2026, two method of use patents expiring in 2027, and one other method of use patent expiring in 2030. In September 2021, we brought patent infringement actions against the generic filers in the U.S. District Court for the District of Delaware, asserting the validity and infringement of the patents challenged by the generic companies.
Matter Involving Our Collaboration/Licensing Partners
Eliquis
In 2017, twenty-five generic companies sent BMS Paragraph-IV certification letters informing BMS that they had filed ANDAs seeking approval of generic versions of Eliquis, challenging the validity and infringement of one or more of the three patents listed in the Orange Book for Eliquis. One of the patents expired in December 2019 and the remaining patents currently are set to expire in 2026 and 2031. Eliquis has been jointly developed and is being commercialized by BMS and Pfizer. BMS and Pfizer filed patent-infringement actions against all generic filers in the U.S. District Court for the District of Delaware and the U.S. District Court for the District of West Virginia, asserting that each of the generic companies’ proposed products would infringe each of the patent(s) that each generic filer challenged. Some generic filers challenged only the 2031 patent, some challenged both the 2031 and 2026 patent, and one generic company challenged all three patents. In August 2020, the U.S. District Court for the District of Delaware ruled that both the 2026 patent and the 2031 patent are valid and infringed by the proposed generic products. In August and September 2020, the generic filers appealed the District Court’s decision to the U.S. Court of Appeals for the Federal Circuit. Prior to the August 2020 ruling, we and BMS settled with certain of the companies on terms not material to us, and we and BMS may settle with other generic companies in the future. In September 2021, the U.S. Court of Appeals for the Federal Circuit affirmed the District Court’s decision.
A2. Legal Proceedings––Product Litigation
We are defendants in numerous cases, including but not limited to those discussed below, related to our pharmaceutical and other products. Plaintiffs in these cases seek damages and other relief on various grounds for alleged personal injury and economic loss.
Asbestos
Between 1967 and 1982, Warner-Lambert owned American Optical Corporation (American Optical), which manufactured and sold respiratory protective devices and asbestos safety clothing. In connection with the sale of American Optical in 1982, Warner-Lambert agreed to indemnify the purchaser for certain liabilities, including certain asbestos-related and other claims. Warner-Lambert was acquired by Pfizer in 2000 and is a wholly owned subsidiary of Pfizer. Warner-Lambert is actively engaged in the defense of, and will continue to explore various means of resolving, these claims.

Numerous lawsuits against American Optical, Pfizer and certain of its previously owned subsidiaries are pending in various federal and state courts seeking damages for alleged personal injury from exposure to products allegedly containing asbestos and other allegedly hazardous materials sold by Pfizer and certain of its previously owned subsidiaries.
There also are a small number of lawsuits pending in various federal and state courts seeking damages for alleged exposure to asbestos in facilities owned or formerly owned by Pfizer or its subsidiaries.
Effexor
Beginning in 2011, actions, including purported class actions, were filed in various federal courts against Wyeth and, in certain of the actions, affiliates of Wyeth and certain other defendants relating to Effexor XR, which is the extended-release formulation of Effexor. The plaintiffs in each of the class actions seek to represent a class consisting of all persons in the U.S. and its territories who directly purchased, indirectly purchased or reimbursed patients for the purchase of Effexor XR or generic Effexor XR from any of the defendants from June 14, 2008 until the time the defendants’ allegedly unlawful conduct ceased. The plaintiffs in all of the actions allege delay in the launch of generic Effexor XR in the U.S. and its territories, in violation of federal antitrust laws and, in certain of the actions, the antitrust, consumer protection and various other laws of certain states, as the result of Wyeth fraudulently obtaining and improperly listing certain patents for Effexor XR in the Orange Book, enforcing certain patents for Effexor XR and entering into a litigation settlement agreement with a generic drug manufacturer with respect to Effexor XR. Each of the plaintiffs seeks treble damages (for itself in the individual actions or on behalf of the putative class in the
purported class actions) for alleged price overcharges for Effexor XR or generic Effexor XR in the U.S. and its territories since June 14, 2008. All of these actions have been consolidated in the U.S. District Court for the District of New Jersey.
In 2014, the District Court dismissed the direct purchaser plaintiffs’ claims based on the litigation settlement agreement, but declined to dismiss the other direct purchaser plaintiff claims. In 2015, the District Court entered partial final judgments as to all settlement agreement claims, including those asserted by direct purchasers and end-payer plaintiffs, which plaintiffs appealed to the U.S. Court of Appeals for the Third Circuit. In 2017, the U.S. Court of Appeals for the Third Circuit reversed the District Court’s decisions and remanded the claims to the District Court.
Lipitor
Beginning in 2011, purported class actions relating to Lipitor were filed in various federal courts against, among others, Pfizer, certain Pfizer affiliates, and, in most of the actions, Ranbaxy Laboratories Ltd. (Ranbaxy) and certain Ranbaxy affiliates. The plaintiffs in these various actions seek to represent nationwide, multi-state or statewide classes consisting of persons or entities who directly purchased, indirectly purchased or reimbursed patients for the purchase of Lipitor (or, in certain of the actions, generic Lipitor) from any of the defendants from March 2010 until the cessation of the defendants’ allegedly unlawful conduct (the Class Period). The plaintiffs allege delay in the launch of generic Lipitor, in violation of federal antitrust laws and/or state antitrust, consumer protection and various other laws, resulting from (i) the 2008 agreement pursuant to which Pfizer and Ranbaxy settled certain patent litigation involving Lipitor and Pfizer granted Ranbaxy a license to sell a generic version of Lipitor in various markets beginning on varying dates, and (ii) in certain of the actions, the procurement and/or enforcement of certain patents for Lipitor. Each of the actions seeks, among other things, treble damages on behalf of the putative class for alleged price overcharges for Lipitor (or, in certain of the actions, generic Lipitor) during the Class Period. In addition, individual actions have been filed against Pfizer, Ranbaxy and certain of their affiliates, among others, that assert claims and seek relief for the plaintiffs that are substantially similar to the claims asserted and the relief sought in the purported class actions described above. These various actions have been consolidated for pre-trial proceedings in a Multi-District Litigation in the U.S. District Court for the District of New Jersey.
In September 2013 and 2014, the District Court dismissed with prejudice the claims of the direct purchasers. In October and November 2014, the District Court dismissed with prejudice the claims of all other Multi-District Litigation plaintiffs. All plaintiffs have appealed the District Court’s orders dismissing their claims with prejudice to the U.S. Court of Appeals for the Third Circuit. In addition, the direct purchaser class plaintiffs appealed the order denying their motion to amend the judgment and for leave to amend their complaint to the Court of Appeals. In 2017, the Court of Appeals reversed the District Court’s decisions and remanded the claims to the District Court.
Also, in 2013, the State of West Virginia filed an action in West Virginia state court against Pfizer and Ranbaxy, among others, that asserts claims and seeks relief on behalf of the State of West Virginia and residents of that state that are substantially similar to the claims asserted and the relief sought in the purported class actions described above.
EpiPen (Direct Purchaser)
In February 2020, a lawsuit was filed in the U.S. District Court for the District of Kansas against Pfizer, its affiliates King and Meridian, and various Mylan entities, on behalf of a purported U.S. nationwide class of direct purchaser plaintiffs who purchased EpiPen devices directly from the defendants. Plaintiffs in this action generally allege that Pfizer and Mylan conspired to delay market entry of generic EpiPen through the settlement of patent litigation regarding EpiPen, and thereby delayed market entry of generic EpiPen in violation of federal antitrust law. Plaintiffs seek treble damages for alleged overcharges for EpiPen since 2011. In July 2021, the District Court granted defendants’ motion to dismiss the direct purchaser complaint, without prejudice. In September 2021, plaintiffs filed an amended complaint.
Nexium 24HR and Protonix
A number of individual and multi-plaintiff lawsuits have been filed against Pfizer, certain of its subsidiaries and/or other pharmaceutical manufacturers in various federal and state courts alleging that the plaintiffs developed kidney-related injuries purportedly as a result of the ingestion of certain proton pump inhibitors. The cases against Pfizer involve Protonix and/or Nexium 24HR and seek compensatory and punitive damages and, in some cases, treble damages, restitution or disgorgement. In 2017, the federal actions were ordered transferred for coordinated pre-trial proceedings to a Multi-District Litigation in the U.S. District Court for the District of New Jersey. As part of our Consumer Healthcare JV transaction with GSK, the JV has agreed to assume, and to indemnify Pfizer for, liabilities arising out of such litigation to the extent related to Nexium 24HR.
Docetaxel
•Personal Injury Actions
A number of lawsuits have been filed against Hospira and Pfizer in various federal and state courts alleging that plaintiffs who were treated with Docetaxel developed permanent hair loss. The significant majority of the cases also name other defendants, including the manufacturer of the branded product, Taxotere. Plaintiffs seek compensatory and punitive damages.
In 2016, the federal cases were transferred for coordinated pre-trial proceedings to a Multi-District Litigation in the U.S. District Court for the Eastern District of Louisiana.
•Mississippi Attorney General Government Action
In 2018, the Attorney General of Mississippi filed a complaint in Mississippi state court against the manufacturer of the branded product and eight other manufacturers including Pfizer and Hospira, alleging, with respect to Pfizer and Hospira, a failure to warn about a risk of permanent hair loss in violation of the Mississippi Consumer Protection Act. The action seeks civil penalties and injunctive relief.
Zantac
A number of lawsuits have been filed against Pfizer in various federal and state courts alleging that plaintiffs developed various types of cancer, or face an increased risk of developing cancer, purportedly as a result of the ingestion of Zantac. The significant majority of these cases also name other defendants that have historically manufactured and/or sold Zantac. Pfizer has not sold Zantac since 2006, and only sold an OTC version of the product. Plaintiffs seek compensatory and punitive damages.
In February 2020, the federal actions were transferred for coordinated pre-trial proceedings to a Multi-District Litigation in the U.S. District Court for the Southern District of Florida. Plaintiffs in the Multi-District Litigation have filed against Pfizer and many other defendants a master personal injury complaint, a consolidated consumer class action complaint alleging, among other things, claims under consumer protection
statutes of all 50 states, and a medical monitoring complaint seeking to certify medical monitoring classes under the laws of 13 states. Plaintiffs previously had filed a consolidated third-party payor class action complaint alleging violation of the federal Racketeer Influenced and Corrupt Organizations Act (RICO) statute and seeking reimbursement for payments made for the prescription version of Zantac, but the Multi-District Litigation court dismissed that complaint; Plaintiffs have appealed the dismissal to the U.S. Court of Appeals for the Eleventh Circuit. In addition, (i) Pfizer has received service of Canadian class action complaints naming Pfizer and other defendants, and seeking compensatory and punitive damages for personal injury and economic loss, allegedly arising from the defendants’ sale of Zantac in Canada; and (ii) the State of New Mexico and the Mayor and City Council of Baltimore separately filed civil actions against Pfizer and many other defendants in state court, alleging various state statutory and common law claims in connection with the defendants’ alleged sale of Zantac in those jurisdictions. In April 2021, a Judicial Council Coordinated Proceeding was created in the Superior Court of California in Alameda County to coordinate personal injury actions against Pfizer and other defendants filed in California state court.
Chantix
Beginning in August 2021, a number of putative class actions have been filed against Pfizer in various U.S. federal courts following Pfizer’s voluntary recall of Chantix due to the presence of a nitrosamine, N-nitroso-varenicline. Plaintiffs assert that they suffered economic harm purportedly as a result of purchasing Chantix or generic varenicline medicines sold by Pfizer. Plaintiffs seek to represent nationwide and state-specific classes and seek various remedies, including damages and medical monitoring. Similar putative class actions have been filed in Canada and Israel, where the product brand is Champix.
A3. Legal Proceedings––Commercial and Other Matters
Monsanto-Related Matters
In 1997, Monsanto Company (Former Monsanto) contributed certain chemical manufacturing operations and facilities to a newly formed corporation, Solutia Inc. (Solutia), and spun off the shares of Solutia. In 2000, Former Monsanto merged with Pharmacia & Upjohn Company to form Pharmacia. Pharmacia then transferred its agricultural operations to a newly created subsidiary, named Monsanto Company (New Monsanto), which it spun off in a two-stage process that was completed in 2002. Pharmacia was acquired by Pfizer in 2003 and is a wholly owned subsidiary of Pfizer.
In connection with its spin-off that was completed in 2002, New Monsanto assumed, and agreed to indemnify Pharmacia for, any liabilities related to Pharmacia’s former agricultural business. New Monsanto has defended and/or is defending Pharmacia in connection with various claims and litigation arising out of, or related to, the agricultural business, and has been indemnifying Pharmacia when liability has been imposed or settlement has been reached regarding such claims and litigation.
In connection with its spin-off in 1997, Solutia assumed, and agreed to indemnify Pharmacia for, liabilities related to Former Monsanto’s chemical businesses. As the result of its reorganization under Chapter 11 of the U.S. Bankruptcy Code, Solutia’s indemnification obligations relating to Former Monsanto’s chemical businesses are primarily limited to sites that Solutia has owned or operated. In addition, in connection with its spin-off that was completed in 2002, New Monsanto assumed, and agreed to indemnify Pharmacia for, any liabilities primarily related to Former Monsanto’s chemical businesses, including, but not limited to, any such liabilities that Solutia assumed. Solutia’s and New Monsanto’s assumption of, and agreement to indemnify Pharmacia for, these liabilities apply to pending actions and any future actions related to Former Monsanto’s chemical businesses in which Pharmacia is named as a defendant, including, without limitation, actions asserting environmental claims, including alleged exposure to polychlorinated biphenyls. Solutia and/or New Monsanto are defending Pharmacia in connection with various claims and litigation arising out of, or related to, Former Monsanto’s chemical businesses, and have been indemnifying Pharmacia when liability has been imposed or settlement has been reached regarding such claims and litigation.
Environmental Matters
In 2009, we submitted a revised site-wide feasibility study with regard to the Wyeth Holdings Corporation (formerly, American Cyanamid Company) discontinued industrial chemical facility in Bound Brook, New Jersey. In 2011, Wyeth Holdings Corporation executed an Administrative Settlement Agreement and Order on Consent for Removal Action (the 2011 Administrative Settlement Agreement) with the U.S. Environmental Protection Agency (EPA) with regard to the Bound Brook facility. In accordance with the 2011 Administrative Settlement Agreement, we completed construction of an interim remedy. In 2012, the EPA issued a final remediation plan for the Bound Brook facility’s main plant area. In 2013, Wyeth Holdings Corporation (now Wyeth Holdings LLC) entered into an Administrative Settlement Agreement and Order on Consent with the EPA to allow us to undertake detailed engineering design of the remedy for the main plant area and to perform a focused feasibility study for two adjacent lagoons. In 2015, the U.S., on behalf of the EPA, filed a complaint and consent decree with the federal District Court for the District of New Jersey that allows Wyeth Holdings LLC to complete the design and to implement the remedy for the main plant area. The consent decree (which supersedes the 2011 Administrative Settlement Agreement) was entered by the District Court in 2015. In 2018, the EPA issued a final remediation plan for the two adjacent lagoons. In 2019, Wyeth Holdings LLC entered into an Administrative Settlement Agreement and Order on Consent with the EPA to allow us to undertake detailed engineering design of the remedy for the lagoons. In September 2021, the U.S., on behalf of the EPA, filed a complaint and consent decree with the federal District Court for the District of New Jersey, which the court approved in November 2021, that will allow Wyeth Holdings LLC to complete the design and implement the remedy for the two adjacent lagoons.
We have accrued for the estimated costs of the site remedies for the Bound Brook facility.
We are a party to a number of other proceedings brought under the Comprehensive Environmental Response, Compensation, and Liability Act of 1980, as amended, and other state, local or foreign laws in which the primary relief sought is the cost of past and/or future remediation.
Contracts with Iraqi Ministry of Health
In 2017, a number of U.S. service members, civilians, and their families brought a complaint in the U.S. District Court for the District of Columbia against a number of pharmaceutical and medical devices companies, including Pfizer and certain of its subsidiaries, alleging that the defendants violated the U.S. Anti-Terrorism Act. The complaint alleges that the defendants provided funding for terrorist organizations through their sales practices pursuant to pharmaceutical and medical device contracts with the Iraqi Ministry of Health, and seeks monetary relief. In July 2020, the District Court granted defendants’ motions to dismiss and dismissed all of plaintiffs’ claims. In January 2022, the Court of Appeals reversed the District Court’s decision. In February 2022, the defendants filed for en banc review of the Court of Appeals’ decision.
Allergan Complaint for Indemnity
In 2019, Pfizer was named as a defendant in a complaint, along with King, filed by Allergan Finance LLC (Allergan) in the Supreme Court of the State of New York, asserting claims for indemnity related to Kadian, which was owned for a short period by King in 2008, prior to Pfizer's acquisition of King in 2010. This suit was voluntarily discontinued without prejudice in January 2021.
Breach of Contract––Xalkori/Lorbrena
We are a defendant in a breach of contract action brought by New York University (NYU) in the Supreme Court of the State of New York (Supreme Court). NYU alleges that it is entitled to royalties on Pfizer’s sales of Xalkori under the terms of a Research and License Agreement between NYU and Sugen, Inc. Sugen, Inc. was acquired by Pharmacia in August 1999, and Pharmacia was acquired by Pfizer in 2003 and is a wholly owned subsidiary of Pfizer. The action was originally filed in 2013. In 2015, the Supreme Court dismissed the action and, in 2017, the New York State Appellate Division reversed the decision and remanded the proceedings to the Supreme Court. In January 2020, the Supreme Court denied both parties’ summary judgment motions.
In October 2020, NYU filed a separate breach of contract action against Pfizer alleging that it is entitled to royalties on sales of Lorbrena under the terms of the same NYU-Sugen, Inc. Research and Licensing Agreement. In February 2022, the parties reached an agreement to settle both breach of contract actions on terms not material to Pfizer.
Viatris Securities Litigation
In October 2021, a putative class action was filed in the Court of Common Pleas of Allegheny County, Pennsylvania on behalf of former Mylan N.V. shareholders who received Viatris common stock in exchange for Mylan shares in connection with the spin-off of the Upjohn Business and its combination with Mylan (the Transactions). Viatris, Pfizer, and certain of each company’s current and former officers, directors and employees are named as defendants. The complaint alleges that the defendants violated certain provisions of the Securities Act of 1933 in connection with certain disclosures made in or omitted from the registration statement and related prospectus issued in connection with the Transactions. Plaintiff seeks damages, costs and expenses and other equitable and injunctive relief.
A4. Legal Proceedings––Government Investigations
We are subject to extensive regulation by government agencies in the U.S., other developed markets and multiple emerging markets in which we operate. Criminal charges, substantial fines and/or civil penalties, limitations on our ability to conduct business in applicable jurisdictions, corporate integrity or deferred prosecution agreements, as well as reputational harm and increased public interest in the matter could result from government investigations in the U.S. and other jurisdictions in which we do business. In addition, in a qui tam lawsuit in which the government declines to intervene, the relator may still pursue a suit for the recovery of civil damages and penalties on behalf of the government. Among the investigations by government agencies are the matters discussed below.
Greenstone Investigations
•U.S. Department of Justice Antitrust Division Investigation
Since July 2017, the U.S. Department of Justice's Antitrust Division has been investigating our former Greenstone generics business. We believe this is related to an ongoing broader antitrust investigation of the generic pharmaceutical industry. We have produced records relating to this investigation.
•State Attorneys General and Multi-District Generics Antitrust Litigation
In April 2018, Greenstone received requests for information from the Antitrust Department of the Connecticut Office of the Attorney General. In May 2019, Attorneys General of more than 40 states plus the District of Columbia and Puerto Rico filed a complaint against a number of pharmaceutical companies, including Greenstone and Pfizer. The matter has been consolidated with a Multi-District Litigation in the Eastern District of Pennsylvania. As to Greenstone and Pfizer, the complaint alleges anticompetitive conduct in violation of federal and state antitrust laws and state consumer protection laws. In June 2020, the State Attorneys General filed a new complaint against a large number of companies, including Greenstone and Pfizer, making similar allegations, but concerning a new set of drugs. This complaint was transferred to the Multi-District Litigation in July 2020. The Multi-District Litigation also includes civil complaints filed by private plaintiffs and state counties against Pfizer, Greenstone and a significant number of other defendants asserting allegations that generally overlap with those asserted by the State Attorneys General.
Subpoena relating to Manufacturing of Quillivant XR
In October 2018, we received a subpoena from the U.S. Attorney’s Office for the Southern District of New York (SDNY) seeking records relating to our relationship with another drug manufacturer and its production and manufacturing of drugs including, but not limited to, Quillivant XR. We have produced records pursuant to the subpoena.
Government Inquiries relating to Meridian Medical Technologies
In February 2019, we received a civil investigative demand from the U.S. Attorney’s Office for the SDNY. The civil investigative demand seeks records and information related to alleged quality issues involving the manufacture of auto-injectors at the Meridian site. In August 2019, we received a HIPAA subpoena from the U.S. Attorney’s Office for the Eastern District of Missouri seeking similar records and information. We are producing records in response to these requests.
U.S. Department of Justice/SEC Inquiry relating to Russian Operations
In June 2019, we received an informal request from the U.S. Department of Justice’s FCPA Unit seeking documents relating to our operations in Russia. In September 2019, we received a similar request from the SEC’s FCPA Unit. We have produced records pursuant to these requests.
Docetaxel––Mississippi Attorney General Government Investigation
See Legal Proceedings––Product Litigation––Docetaxel––Mississippi Attorney General Government Investigation above for information regarding a government investigation related to Docetaxel marketing practices.
U.S. Department of Justice Inquiries relating to India Operations
In March 2020, we received an informal request from the U.S. Department of Justice's Consumer Protection Branch seeking documents relating to our manufacturing operations in India, including at our former facility located at Irrungattukottai in India. In April 2020, we received a similar request from the U.S. Attorney’s Office for the SDNY regarding a civil investigation concerning operations at our facilities in India. We are producing records pursuant to these requests.
U.S. Department of Justice/SEC Inquiry relating to China Operations
In June 2020, we received an informal request from the U.S. Department of Justice's FCPA Unit seeking documents relating to our operations in China. In August 2020, we received a similar request from the SEC’s FCPA Unit. We are producing records pursuant to these requests.
Zantac––State of New Mexico and Mayor and City Council of Baltimore Civil Actions
See Legal Proceedings––Product Litigation––Zantac above for information regarding civil actions separately filed by the State of New Mexico and the Mayor and City Council of Baltimore alleging various state statutory and common law claims in connection with the defendants’ alleged sale of Zantac in those jurisdictions.
A5. Legal Proceedings––Matters Resolved During 2021
During 2021, certain matters, including the matter discussed below, were resolved or became the subject of definitive settlement agreements or settlement agreements-in-principle.
EpiPen
Beginning in 2017, purported class actions were filed in various federal courts by indirect purchasers of EpiPen against Pfizer, and/or its current and former affiliates King and Meridian, and/or various entities affiliated with Mylan, and Mylan former Chief Executive Officer, Heather Bresch. The plaintiffs in these actions represent U.S. nationwide classes comprising persons or entities who paid for any portion of the end-user purchase price of an EpiPen between 2009 until the cessation of the defendants’ allegedly unlawful conduct. Against Pfizer and/or its affiliates, plaintiffs in these actions generally allege that Pfizer’s and/or its affiliates’ settlement of patent litigation regarding EpiPen delayed market entry of generic EpiPen in violation of federal and various state antitrust laws. At least one lawsuit also alleges that Pfizer and/or Mylan violated RICO. Plaintiffs also filed various federal antitrust, state consumer protection and unjust enrichment claims against, and relating to conduct attributable solely to, Mylan and/or its affiliates regarding EpiPen. Plaintiffs seek treble damages for alleged overcharges for EpiPen since 2011. In 2017, all of these indirect purchase actions were consolidated for coordinated pre-trial proceedings in a Multi-District Litigation in the U.S. District Court for the District of Kansas with other EpiPen-related actions against Mylan and/or its affiliates to which Pfizer, King and Meridian are not parties. In July 2021, Pfizer and plaintiffs filed a stipulation of settlement to resolve the Multi-District Litigation for $345 million. The District Court approved the settlement in November 2021, and the payment was made in accordance with the terms of the settlement agreement.
B. Guarantees and Indemnifications
In the ordinary course of business and in connection with the sale of assets and businesses and other transactions, we often indemnify our counterparties against certain liabilities that may arise in connection with the transaction or that are related to events and activities prior to or following a transaction. If the indemnified party were to make a successful claim pursuant to the terms of the indemnification, we may be required to reimburse the loss. These indemnifications are generally subject to various restrictions and limitations. Historically, we have not paid significant amounts under these provisions and, as of December 31, 2021, the estimated fair value of these indemnification obligations has been included in our financial statements and is not material to Pfizer.
In addition, in connection with our entry into certain agreements and other transactions, our counterparties may agree to indemnify us. For example, in November 2020, we and Mylan completed the transaction to spin-off our Upjohn Business and combine it with Mylan to form Viatris. As part of the transaction and as previously disclosed, Viatris has agreed to assume, and to indemnify Pfizer for, liabilities arising out of certain matters.
We have also guaranteed the long-term debt of certain companies that we acquired and that now are subsidiaries of Pfizer. See Note 7D.
C. Certain Commitments
As of December 31, 2021, we had commitments totaling $5.2 billion that are legally binding and enforceable. These commitments include payments relating to potential milestone payments deemed reasonably likely to occur, and purchase obligations for goods and services.
See Note 5A for information on the TCJA repatriation tax liability.
D. Contingent Consideration for Acquisitions
We may be required to make payments to sellers for certain prior business combinations that are contingent upon future events or outcomes. See Note 1E. The estimated fair value of contingent consideration as of December 31, 2021 is $697 million, of which $135 million is recorded in Other current liabilities and $563 million in Other noncurrent liabilities, and as of December 31, 2020 is $689 million, of which $123 million is recorded in Other current liabilities and $566 million in Other noncurrent liabilities. The increase in the contingent consideration balance from December 31, 2020 is primarily due to fair value adjustments, partially offset by payments made upon the achievement of certain sales-based milestones.
E. Insurance
Our insurance coverage reflects market conditions (including cost and availability) existing at the time it is written, and our decision to obtain insurance coverage or to self-insure varies accordingly. Depending upon the cost and availability of insurance and the nature of the risk involved, the amount of self-insurance may be significant. The cost and availability of coverage have resulted in self-insuring certain exposures, including product liability. If we incur substantial liabilities that are not covered by insurance or substantially exceed insurance
coverage and that are in excess of existing accruals, there could be a material adverse effect on our cash flows or results of operations in the period in which the amounts are paid and/or accrued.
v3.22.0.1
Segment, Geographic and Other Revenue Information
 12 Months Ended
Dec. 31, 2021
Segment Reporting [Abstract]  
Segment, Geographic and Other Revenue Information Segment, Geographic and Other Revenue Information
A. Segment Information
We regularly review our operating segments and the approach used by management to evaluate performance and allocate resources. With the formation of the Consumer Healthcare JV in 2019 and the completion of the spin-off of our Upjohn Business in the fourth quarter of 2020, Pfizer transformed into a more focused, global leader in science-based innovative medicines and vaccines and beginning in the fourth quarter of 2020 operated as a single operating segment engaged in the discovery, development, manufacturing, marketing, sale and distribution of biopharmaceutical products worldwide. At the beginning of our fiscal fourth quarter of 2021, we reorganized our commercial operations and began to manage our commercial operations through a new global structure consisting of two operating segments, each led by a single manager: Biopharma, our innovative science-based biopharmaceutical business and PC1, our global contract development and manufacturing organization and a leading supplier of specialty active pharmaceutical ingredients. Biopharma is a science-based medicines business that includes six therapeutic areas – Oncology, Inflammation & Immunology, Rare Disease, Hospital, Vaccines and Internal Medicine. The Hospital therapeutic area commercializes our global portfolio of sterile injectable and anti-infective medicines.
Each operating segment has responsibility for its commercial activities. Regional commercial organizations market, distribute and sell our products and are supported by global platform functions that are responsible for the research, development, manufacturing and supply of our products and global corporate enabling functions. Biopharma receives its R&D services from GPD and WRDM. These services include IPR&D projects for new investigational products and additional indications for in-line products. Each business has a geographic footprint across developed and emerging markets. Our chief operating decision maker uses the revenues and earnings of the operating segments, among other factors, for performance evaluation and resource allocation. Biopharma is the only reportable segment. We have revised prior-period information (Revenues and Earnings, as defined by management) to conform to the current management structure.
Other Costs and Business Activities
Certain pre-tax costs are not allocated to our operating segment results, such as costs associated with the following:
•WRDM––the R&D and Medical expenses managed by our WRDM organization, which is generally responsible for research projects for our Biopharma portfolio until proof-of-concept is achieved and then for transitioning those projects to the GPD organization for possible clinical and commercial development. R&D spending may include upfront and milestone payments for intellectual property rights. The WRDM organization also has responsibility for certain science-based and other platform-services organizations, which provide end-to-end technical expertise and other services to the various R&D projects, as well as the Worldwide Medical and Safety group, which ensures that Pfizer provides all stakeholders––including patients, healthcare providers, pharmacists, payers and health authorities––with complete and up-to-date information on the risks and benefits associated with Pfizer products so that they can make appropriate decisions on how and when to use Pfizer’s medicines.
•GPD––the costs associated with our GPD organization, which is generally responsible for clinical trials from WRDM in the Biopharma portfolio, including late-stage portfolio spend. GPD also provides technical support and other services to Pfizer R&D projects. GPD is responsible for facilitating all regulatory submissions and interactions with regulatory agencies.
•Corporate and Other Unallocated––the costs associated with (i) corporate enabling functions (such as digital, global real estate operations, legal, finance, human resources, worldwide public affairs, compliance and worldwide procurement, among others), all strategy, business development, portfolio management and valuation capabilities, patient advocacy activities and certain compensation and other corporate costs, such as interest income and expense, and gains and losses on investments; (ii) overhead expenses primarily associated with our manufacturing (which include manufacturing variances associated with production) operations that are not directly assessed to an operating segment, as business unit (segment) management does not manage these costs; and (iii) our share of earnings from the Consumer Healthcare JV.
•Certain transactions and events such as (i) purchase accounting adjustments, where we incur expenses associated with the amortization of fair value adjustments to inventory, intangible assets and PP&E; (ii) acquisition-related items, where we incur costs for executing the transaction, integrating the acquired operations and restructuring the combined company; and (iii) certain significant items, representing substantive and/or unusual, and in some cases recurring, items (such as pension and postretirement actuarial remeasurement gains and losses, gains on the completion of joint venture transactions, restructuring charges, legal charges or net gains and losses on investments in equity securities) that are evaluated on an individual basis by management and that, either as a result of their nature or size, would not be expected to occur as part of our normal business on a regular basis. Such items can include, but are not limited to, non-acquisition-related restructuring costs, as well as costs incurred for legal settlements, asset impairments and disposals of assets or businesses, including, as applicable, any associated transition activities.
The operating results of PC1, our global contract development and manufacturing organization, and through July 31, 2019 our former Consumer Healthcare business are included in Other business activities.
Segment Assets
We manage our assets on a total company basis, not by operating segment, as our operating assets are shared or commingled. Therefore, our chief operating decision maker does not regularly review any asset information by operating segment and, accordingly, we do not report asset information by operating segment. Total assets were $181 billion as of December 31, 2021 and $154 billion as of December 31, 2020.
Selected Income Statement Information
The following table provides selected income statement information by reportable segment:
 Revenues
Earnings(a)
Depreciation and Amortization(b)
Year Ended December 31,Year Ended December 31,Year Ended December 31,
(MILLIONS OF DOLLARS)20212020 2019 20212020 201920212020 2019
Reportable Segment:
Biopharma$79,557 $40,724 $38,013 $40,226 $27,089 $24,419 $1,439 $1,013 $978 
Other business activities(c)
1,731 926 2,892 (10,396)(12,308)(11,216)598 603 592 
Reconciling Items:
Purchase accounting adjustments— — — (3,175)(3,117)(4,153)3,067 3,047 4,145 
Acquisition-related costs— — — (52)(44)(185)— — 3 
Certain significant items(d)
— — — (2,292)(4,584)2,456 87 18 37 
$81,288 $41,651 $40,905 $24,311 $7,036 $11,321 $5,191 $4,681 $5,755 
(a)Income from continuing operations before provision/(benefit) for taxes on income. Biopharma’s earnings include dividend income from our investment in ViiV of $166 million in 2021, $278 million in 2020 and $220 million in 2019.
(b)Certain production facilities are shared. Depreciation is allocated based on estimates of physical production. Amounts here relate solely to the depreciation and amortization associated with continuing operations.
(c)Other business activities include revenues and costs associated with PC1, as well as costs associated with global WRDM and GPD platform functions, global corporate enabling functions and other corporate items, as noted above, that we do not allocate to our operating segments. In 2019, Other business activities also include revenues and costs associated with our former Consumer Healthcare business through July 31, 2019. See Note 2C.
(d)Certain significant items are substantive and/or unusual, and in some cases recurring, items (as noted above) that, either as a result of their nature or size, would not be expected to occur as part of our normal business on a regular basis. For Earnings in 2021, includes, among other items: (i) a $2.1 billion charge for IPR&D related to our acquisition of Trillium, which was accounted for as an asset acquisition and recorded in Research and development expenses, (ii) restructuring charges/(credits) and implementation costs and additional depreciation—asset restructuring of $1.3 billion ($450 million recorded in Selling, informational and administrative expenses and the remaining amount primarily recorded in Restructuring charges and certain acquisition-related costs) and (iii) upfront and milestone payments on collaborative and licensing arrangements of $1.1 billion recorded in Research and development expenses, partially offset by (iv) actuarial valuation and other pension and postretirement plan gains of $1.6 billion recorded in Other (income)/deductions––net and (v) gains on equity securities of $1.3 billion recorded in Other (income)/deductions––net. For Earnings in 2020, includes, among other items; (i) charges of $1.7 billion related to certain asset impairments recorded in Other (income)/deductions––net, (ii) actuarial valuation and other pension and postretirement plan losses of $1.1 billion recorded in Other (income)/deductions––net and (iii) restructuring charges/(credits) and implementation costs and additional depreciation—asset restructuring of $791 million ($197 million recorded in Selling, informational and administrative expenses and the remaining amount primarily recorded in Restructuring charges and certain acquisition-related costs). For Earnings in 2019, includes, among other items: (i) a pre-tax gain of $8.1 billion recorded in (Gain) on completion of Consumer Healthcare JV transaction associated with the completion of the Consumer Healthcare JV transaction, partially offset by (ii) charges of $2.8 billion related to certain asset impairments recorded in Other (income)/deductions––net and (iii) actuarial valuation and other pension and postretirement plan losses of $750 million recorded in Other (income)/deductions––net. For additional information, see Notes 2A, 2C, 3 and 4.

B. Geographic Information
The following summarizes revenues by geographic area:
 Year Ended December 31,
(MILLIONS)202120202019
United States$29,746 $21,455 $20,326 
Developed Europe18,336 7,788 7,729 
Developed Rest of World12,506 4,036 4,022 
Emerging Markets20,701 8,372 8,828 
Revenues
$81,288 $41,651 $40,905 
Revenues exceeded $500 million in each of 21, 8 and 10 countries outside the U.S. in 2021, 2020 and 2019, respectively. The U.S. is the only country to contribute more than 10% of total revenue in 2021, 2020 and 2019. As a percentage of revenues, our largest national market outside the U.S. was Japan, which contributed 9% of total revenue in 2021 and 6% in each of 2020 and 2019.
We and our collaboration partner, BioNTech, have entered into agreements to supply pre-specified doses of Comirnaty with multiple developed and emerging nations around the world and are continuing to deliver doses of Comirnaty under such agreements. We currently sell the Comirnaty vaccine directly to government and government sponsored customers. This includes supply agreements entered into in November 2020 and February and May 2021 with the EC on behalf of the different EU member states and certain other countries. Each EU member state submits its own Comirnaty vaccine order to us and is responsible for payment pursuant to terms of the supply agreements negotiated by the EC.
C. Other Revenue Information

Significant Customers

Our prescription pharmaceutical products are sold principally to wholesalers, but we also sell directly to retailers, hospitals, clinics, government agencies and pharmacies. In the U.S., we primarily sell our vaccine products directly to the federal government, CDC, wholesalers, individual provider offices, retail pharmacies and integrated delivery networks. Outside the U.S., we primarily sell our vaccines to government and non-government institutions.
The following summarizes revenue, as a percentage of total revenues, for our three largest U.S. wholesaler customers:
 Year Ended December 31,
202120202019
McKesson, Inc.
9 %16 %15 %
AmerisourceBergen Corporation
7 %14 %11 %
Cardinal Health, Inc.5 %10 %9 %
Collectively, our three largest U.S. wholesaler customers represented 24%, 30% and 25% of total trade accounts receivable as of December 31, 2021, 2020 and 2019.
Additionally, revenues from the U.S. government represented 13% of total revenues for 2021, and primarily represent sales of Comirnaty. Accounts receivable from the U.S. government represented 12% of total trade accounts receivable as of December 31, 2021, and primarily relate to sales of Comirnaty.

Significant Product Revenues
The following provides detailed revenue information for several of our major products:
(MILLIONS)Year Ended December 31,
PRODUCTPRIMARY INDICATION OR CLASS202120202019
TOTAL REVENUES(a)
$81,288 $41,651 $40,905 
PFIZER BIOPHARMACEUTICALS GROUP (BIOPHARMA)(a), (b)
$79,557 $40,724 $38,013 
Vaccines$42,625 $6,575 $6,504 
Comirnaty direct sales and alliance revenues
Active immunization to prevent COVID-19
36,781 154 — 
Prevnar family(c)
Pneumococcal disease5,272 5,850 5,847 
Nimenrix
Meningococcal ACWY disease193 221 230 
FSME-IMMUN/TicoVac
Tick-borne encephalitis disease
185 196 220 
TrumenbaMeningococcal B disease118 112 135 
All other Vaccines
Various74 42 73 
Oncology$12,333 $10,867 $9,014 
IbranceHR-positive/HER2-negative metastatic breast cancer5,437 5,392 4,961 
Xtandi alliance revenuesmCRPC, nmCRPC, mCSPC1,185 1,024 838 
Inlyta
Advanced RCC1,002 787 477 
Sutent
Advanced and/or metastatic RCC, adjuvant RCC, refractory GIST (after disease progression on, or intolerance to, imatinib mesylate) and advanced pancreatic neuroendocrine tumor
673 819 936 
Bosulif
Philadelphia chromosome–positive chronic myelogenous leukemia540 450 365 
Xalkori
ALK-positive and ROS1-positive advanced NSCLC493 544 530 
Ruxience(d)
Non-hodgkin’s lymphoma, chronic lymphocytic leukemia, granulomatosis with polyangiitis (Wegener’s Granulomatosis) and microscopic polyangiitis491 170 (1)
Retacrit(d)
Anemia444 386 225 
Zirabev(d)
Treatment of mCRC; unresectable, locally advanced, recurrent or metastatic NSCLC; recurrent glioblastoma; metastatic RCC; and persistent, recurrent or metastatic cervical cancer444 143 1 
Lorbrena
ALK-positive metastatic NSCLC
266 204 115 
AromasinPost-menopausal early and advanced breast cancer211 148 136 
Trazimera(d)
HER-positive breast cancer and metastatic stomach cancers
197 98 6 
BesponsaRelapsed or refractory B-cell acute lymphoblastic leukemia 192 182 157 
Braftovi
In combination with Mektovi for metastatic melanoma in patients with a BRAFV600E/K mutation and, in combination with Erbitux® (cetuximab), for the treatment of BRAFV600E-mutant mCRC after prior therapy
187 160 48 
Bavencio alliance revenuesLocally advanced or metastatic urothelial carcinoma; metastatic Merkel cell carcinoma; immunotherapy and tyrosine kinase inhibitor combination for patients with advanced RCC178 80 49 
Mektovi
In combination with Braftovi for metastatic melanoma in patients with a BRAFV600E/K mutation
155 142 49 
All other Oncology
Various238 137 122 
Internal Medicine$9,329 $9,003 $8,790 
Eliquis alliance revenues and direct sales
Nonvalvular atrial fibrillation, deep vein thrombosis, pulmonary embolism5,970 4,949 4,220 
Premarin family
Symptoms of menopause563 680 734 
Chantix/Champix
An aid to smoking cessation treatment in adults 18 years of age or older
398 919 1,107 
BMP2
Development of bone and cartilage266 274 287 
Toviaz
Overactive bladder238 252 250 
PristiqDepression187 171 176 
All other Internal Medicine
Various1,706 1,758 2,016 
(MILLIONS)Year Ended December 31,
PRODUCTPRIMARY INDICATION OR CLASS202120202019
Hospital(a)
$7,301 $6,777 $6,695 
Sulperazon
Bacterial infections683 618 684 
MedrolAnti-inflammatory glucocorticoid432 402 469 
ZaviceftaBacterial infections413 212 108 
Fragmin
Treatment/prevention of venous thromboembolism305 252 253 
ZithromaxBacterial infections278 276 336 
Vfend
Fungal infections267 270 346 
TygacilBacterial infections200 160 197 
PrecedexSedation agent in surgery or intensive care177 260 155 
Zyvox
Bacterial infections173 222 251 
Paxlovid
COVID-19 Infection (high risk population)
76 — — 
IVIg Products(e)
Various430 376 275 
All other Anti-infectives
Various1,453 1,294 1,396 
All other HospitalVarious2,412 2,435 2,225 
Inflammation & Immunology (I&I)$4,431 $4,567 $4,733 
Xeljanz
RA, PsA, UC, active polyarticular course juvenile idiopathic arthritis, ankylosing spondylitis2,455 2,437 2,242 
Enbrel (Outside the U.S. and Canada)
RA, juvenile idiopathic arthritis, PsA, plaque psoriasis, pediatric plaque psoriasis, ankylosing spondylitis and nonradiographic axial spondyloarthritis
1,185 1,350 1,699 
Inflectra/Remsima(d)
Crohn’s disease, pediatric Crohn’s disease, UC, pediatric UC, RA in combination with methotrexate, ankylosing spondylitis, PsA and plaque psoriasis
657 659 625 
All other I&I
Various134 121 167 
Rare Disease
$3,538 $2,936 $2,278 
Vyndaqel/VyndamaxATTR-cardiomyopathy and polyneuropathy2,015 1,288 473 
BeneFIXHemophilia B438 454 488 
Genotropin
Replacement of human growth hormone389 427 498 
Refacto AF/Xyntha
Hemophilia A304 370 426 
Somavert
Acromegaly277 277 264 
All other Rare Disease
Various115 120 129 
PFIZER CENTREONE(b)
$1,731 $926 $810 
CONSUMER HEALTHCARE BUSINESS(f)
$— $— $2,082 
Total Alliance revenues$7,652 $5,418 $4,648 
Total Biosimilars(d)
$2,343 $1,527 $911 
Total Sterile Injectable Pharmaceuticals(g)
$5,746 $5,315 $5,013 
(a)On December 31, 2021, we completed the sale of our Meridian subsidiary. Prior to its sale, Meridian was managed as part of the Hospital therapeutic area. On November 16, 2020, we completed the spin-off and the combination of our Upjohn Business with Mylan to form Viatris. On December 21, 2020, Pfizer and Viatris completed the termination of the Mylan-Japan collaboration. Beginning in the fourth quarter of 2021, the financial results of Meridian are reflected as discontinued operations for all periods presented. Beginning in the fourth quarter of 2020, the financial results of the Upjohn Business and Mylan-Japan collaboration were reflected as discontinued operations for all periods presented. Prior-period financial information has been restated, as appropriate. See Note 1A.
(b)At the beginning of our fiscal fourth quarter of 2021, we reorganized our commercial operations and began to manage our commercial operations through a new global structure consisting of two operating segments, each led by a single manager: Biopharma, our innovative science-based biopharmaceutical business and PC1. PC1, which previously had been managed within the Hospital therapeutic area, includes revenues from our contract manufacturing, including certain Comirnaty-related manufacturing activities performed on behalf of BioNTech ($320 million for 2021 and $0 million for 2020 and 2019), and active pharmaceutical ingredient sales operation, as well as revenues related to our manufacturing and supply agreements with former legacy Pfizer businesses/partnerships, including but not limited to, transitional manufacturing and supply agreements with Viatris following the spin-off of the Upjohn Business. We have revised prior period information to conform to the current management structure.
(c)Prevnar family include revenues from Prevnar 13/Prevenar 13 (pediatric and adult) and Prevnar 20 (adult).
(d)Biosimilars are highly similar versions of approved and authorized biological medicines and primarily include revenues from Inflectra/Remsima, Ruxience, Retacrit, Zirabev and Trazimera.
(e)Intravenous immunoglobulin (IVIg) products include the revenues from Panzyga, Octagam and Cutaquig.
(f)On July 31, 2019, our Consumer Healthcare business, an OTC medicines business, was combined with GSK’s consumer healthcare business to form a new consumer healthcare JV. See Note 2C.
(g)Total Sterile Injectable Pharmaceuticals represents the total of all branded and generic injectable products in the Hospital therapeutic area, including anti-infective sterile injectable pharmaceuticals.
Remaining Performance Obligations

Contracted revenue expected to be recognized from remaining performance obligations for firm orders in long-term contracts to supply Comirnaty to our customers totals $34.4 billion as of December 31, 2021, which includes amounts received in advance and deferred and amounts that will be invoiced as we deliver the product to our customers in future periods. Of this amount, we expect to recognize revenue of
$22.3 billion in 2022, $11.8 billion in 2023 and $265 million in 2024. Remaining performance obligations exclude arrangements with an original expected contract duration of less than one year.

Deferred Revenues

Our deferred revenues primarily relate to advance payments received or receivable in connection with contracts that we entered into during 2021 and 2020 with various government or government sponsored customers in international markets for supply of Comirnaty. The deferred revenues associated with the advance payments related to Comirnaty total $3.3 billion as of December 31, 2021 and $957 million as of December 31, 2020, with $3.0 billion and $249 million recorded in current liabilities and noncurrent liabilities, respectively as of December 31, 2021, and $957 million recorded in current liabilities as of December 31, 2020. The increase in the Comirnaty deferred revenues during 2021 was the result of additional advance payments received as we entered into new or amended contracts or as we invoiced customers in advance of vaccine deliveries less amounts recognized in Revenues as we delivered doses to our customers. During 2021, we recognized in revenue substantially all of the balance of Comirnaty deferred revenues as of December 31, 2020. The Comirnaty deferred revenues as of December 31, 2021 will be recognized in Revenues proportionately as we deliver doses of the vaccine to our customers and satisfy our performance obligation under the contracts, with the amounts included in current liabilities expected to be recognized in Revenues within the next 12 months, and the amounts included in noncurrent liabilities expected to be recognized in Revenues in 2023 and in the first quarter of 2024. Deferred revenues associated with contracts for other products were not significant as of December 31, 2021 or 2020.
v3.22.0.1
Basis of Presentation and Significant Accounting Policies (Policies)
 12 Months Ended
Dec. 31, 2021
Organization, Consolidation and Presentation of Financial Statements [Abstract]  
Basis of Presentation The consolidated financial statements include the accounts of our parent company and all subsidiaries and are prepared in accordance with U.S. GAAP.
Consolidation The decision of whether or not to consolidate an entity for financial reporting purposes requires consideration of majority voting interests, as well as effective economic or other control over the entity. Typically, we do not seek control by means other than voting interests. For subsidiaries operating outside the U.S., the financial information is included as of and for the year ended November 30 for each year presented. Pfizer's fiscal year-end for U.S. subsidiaries is as of and for the year ended December 31 for each year presented. Substantially all unremitted earnings of international subsidiaries are free of legal and contractual restrictions. All significant transactions among our subsidiaries have been eliminated.
Segment Reporting At the beginning of our fiscal fourth quarter of 2021, we reorganized our commercial operations and began to manage our commercial operations through a new global structure consisting of two operating segments, each led by a single manager: Biopharma, our innovative science-based biopharmaceutical business and PC1, our global contract development and manufacturing organization and a leading supplier of specialty active pharmaceutical ingredients.
New Accounting Standards Adopted in 2021 New Accounting Standard Adopted in 2021On January 1, 2021, we adopted a new accounting standard for income tax that eliminates certain exceptions to the guidance related to the approach for intraperiod tax allocation, the methodology for calculating income taxes in an interim period and the recognition of deferred tax liabilities for outside basis differences. The new guidance also simplifies aspects of the accounting for franchise taxes and enacted changes in tax laws or rates and clarifies the accounting for transactions that result in a step-up in the tax basis of goodwill. The adoption of this guidance did not have a material impact on our consolidated financial statements.
Estimates and Assumptions Estimates and Assumptions
In preparing these financial statements, we use certain estimates and assumptions that affect reported amounts and disclosures. These estimates and assumptions can impact all elements of our financial statements. For example, in the consolidated statements of income, estimates are used when accounting for deductions from revenues, determining the cost of inventory that is sold, allocating cost in the form of depreciation and amortization, and estimating restructuring charges and the impact of contingencies, as well as determining provisions for taxes on income. On the consolidated balance sheets, estimates are used in determining the valuation and recoverability of assets, and in determining the reported amounts of liabilities, all of which also impact the consolidated statements of income. Certain estimates of fair value and amounts recorded in connection with acquisitions, revenue deductions, impairment reviews, restructuring-associated charges, investments and financial instruments, valuation allowances, pension and postretirement benefit plans, contingencies, share-based compensation, and other calculations can result from a complex series of judgments about future events and uncertainties and can rely heavily on estimates and assumptions.

Our estimates are often based on complex judgments and assumptions that we believe to be reasonable, but that can be inherently uncertain and unpredictable. If our estimates and assumptions are not representative of actual outcomes, our results could be materially impacted. As future events and their effects cannot be determined with precision, our estimates and assumptions may prove to be incomplete or inaccurate, or unanticipated events and circumstances may occur that might cause us to change those estimates and assumptions. We are subject to risks and uncertainties that may cause actual results to differ from estimated amounts, such as changes in the healthcare environment, competition, litigation, legislation and regulations. We regularly evaluate our estimates and assumptions using historical experience and expectations about the future. We adjust our estimates and assumptions when facts and circumstances indicate the need for change.
Acquisitions Acquisitions
Our consolidated financial statements include the operations of acquired businesses after the completion of the acquisitions. We account for acquired businesses using the acquisition method of accounting, which requires, among other things, that most assets acquired and liabilities assumed be recognized at their estimated fair values as of the acquisition date and that the fair value of acquired IPR&D be recorded on the balance sheet. Transaction costs are expensed as incurred. Any excess of the consideration transferred over the assigned values of the net assets acquired is recorded as goodwill. When we acquire net assets that do not constitute a business, as defined in U.S. GAAP, no goodwill is recognized and acquired IPR&D is expensed in Research and development expenses.

Contingent consideration in a business combination is included as part of the acquisition cost and is recognized at fair value as of the acquisition date. Fair value is generally estimated by using a probability-weighted discounted cash flow approach. See Note 16D. Any liability resulting from contingent consideration is remeasured to fair value at each reporting date until the contingency is resolved. These changes in fair value are recognized in earnings in Other (income)/deductions––net.
Fair Value Fair Value
We measure certain assets and liabilities at fair value, either upon initial recognition or for subsequent accounting or reporting. We estimate fair value using an exit price approach, which requires, among other things, that we determine the price that would be received to sell an asset or paid to transfer a liability in an orderly market. The determination of an exit price is considered from the perspective of market participants, considering the highest and best use of non-financial assets and, for liabilities, assuming that the risk of non-performance will be the same before and after the transfer.

When estimating fair value, depending on the nature and complexity of the asset or liability, we may use one or all of the following techniques:
•Income approach, which is based on the present value of a future stream of net cash flows.
•Market approach, which is based on market prices and other information from market transactions involving identical or comparable assets or liabilities.
•Cost approach, which is based on the cost to acquire or construct comparable assets, less an allowance for functional and/or economic obsolescence.

Our fair value methodologies depend on the following types of inputs:
•Quoted prices for identical assets or liabilities in active markets (Level 1 inputs).
•Quoted prices for similar assets or liabilities in active markets, or quoted prices for identical or similar assets or liabilities in markets that are not active, or inputs other than quoted prices that are directly or indirectly observable, or inputs that are derived principally from, or corroborated by, observable market data by correlation or other means (Level 2 inputs).
•Unobservable inputs that reflect estimates and assumptions (Level 3 inputs).
The following inputs and valuation techniques are used to estimate the fair value of our financial assets and liabilities:
•Available-for-sale debt securities—third-party matrix-pricing model that uses significant inputs derived from or corroborated by observable market data and credit-adjusted yield curves.
•Equity securities with readily determinable fair values—quoted market prices and observable NAV prices.
•Derivative assets and liabilities—third-party matrix-pricing model that uses inputs derived from or corroborated by observable market data. Where applicable, these models use market-based observable inputs, including interest rate yield curves to discount future cash flow amounts, and forward and spot prices for currencies. The credit risk impact to our derivative financial instruments was not significant.
•Money market funds—observable NAV prices.
We periodically review the methodologies, inputs and outputs of third-party pricing services for reasonableness. Our procedures can include, for example, referencing other third-party pricing models, monitoring key observable inputs (like benchmark interest rates) and selectively performing test-comparisons of values with actual sales of financial instruments.
Foreign Currency Translation Foreign Currency TranslationFor most of our international operations, local currencies have been determined to be the functional currencies. We translate functional currency assets and liabilities to their U.S. dollar equivalents at exchange rates in effect as of the balance sheet date and income and expense amounts at average exchange rates for the period. The U.S. dollar effects that arise from changing translation rates are recorded in Other comprehensive income/(loss). The effects of converting non-functional currency monetary assets and liabilities into the functional currency are recorded in Other (income)/deductions––net. For operations in highly inflationary economies, we translate monetary items at rates in effect as of the balance sheet date, with translation adjustments recorded in Other (income)/deductions––net, and we translate non-monetary items at historical rates.
Revenues and Collaborative Arrangements
Revenue Recognition––We record revenues from product sales when there is a transfer of control of the product from us to the customer. We typically determine transfer of control based on when the product is shipped or delivered and title passes to the customer.
Our Sales Contracts––Sales on credit are typically under short-term contracts. Collections are based on market payment cycles common in various markets, with shorter cycles in the U.S. Sales are adjusted for sales allowances, chargebacks, rebates and sales returns and cash discounts. Sales returns occur due to LOE, product recalls or a changing competitive environment.
Deductions from Revenues––Our gross product revenues are subject to a variety of deductions, which generally are estimated and recorded in the same period that the revenues are recognized. Such variable consideration represents chargebacks, rebates, sales allowances and sales returns. These deductions represent estimates of the related obligations and, as such, knowledge and judgment is required when estimating the impact of these revenue deductions on gross sales for a reporting period.
Provisions for pharmaceutical sales returns––Provisions are based on a calculation for each market that incorporates the following, as appropriate: local returns policies and practices; historical returns as a percentage of sales; an understanding of the reasons for past returns; estimated shelf life by product; an estimate of the amount of time between shipment and return or lag time; and any other factors that could impact the estimate of future returns, such as LOE, product recalls or a changing competitive environment. Generally, returned products are destroyed, and customers are refunded the sales price in the form of a credit.
We record sales incentives as a reduction of revenues at the time the related revenues are recorded or when the incentive is offered, whichever is later. We estimate the cost of our sales incentives based on our historical experience with similar incentives programs to predict customer behavior.
The following outlines our common sales arrangements:
•Customers––Our prescription pharmaceutical products are sold principally to wholesalers, but we also sell directly to retailers, hospitals, clinics, government agencies and pharmacies. In the U.S., we primarily sell our vaccines products directly to the federal government, CDC, wholesalers, individual provider offices, retail pharmacies, and integrated delivery networks. Outside the U.S., we primarily sell our vaccines to government and non-government institutions. Prescription pharmaceutical products that ultimately are used by patients are generally covered under governmental programs, managed care programs and insurance programs, including those managed through PBMs, and are subject to sales allowances and/or rebates payable directly to those programs. Those sales allowances and rebates are generally negotiated, but government programs may have legislated amounts by type of product (e.g., patented or unpatented).
Specifically:
•In the U.S., we sell our products principally to distributors and hospitals. We also have contracts with managed care programs or PBMs and legislatively mandated contracts with the federal and state governments under which we provide rebates based on medicines utilized by the lives they cover. We record provisions for Medicare, Medicaid, and performance-based contract pharmaceutical rebates based upon our experience ratio of rebates paid and actual prescriptions written during prior periods. We apply the experience ratio to the respective period’s sales to determine the rebate accrual and related expense. This experience ratio is evaluated regularly to ensure that the historical trends are as current as practicable. We estimate discounts on branded prescription drug sales to Medicare Part D participants in the Medicare “coverage gap,” also known as the “doughnut hole,” based on the historical experience of beneficiary prescriptions and consideration of the utilization that is expected to result from the discount in the coverage gap. We evaluate this estimate regularly to ensure that the historical trends and future expectations are as current as practicable. For performance-based contract rebates, we also consider current contract terms, such as changes in formulary status and rebate rates.
•Outside the U.S., the majority of our pharmaceutical sales allowances are contractual or legislatively mandated and our estimates are based on actual invoiced sales within each period, which reduces the risk of variations in the estimation process. In certain European countries, rebates are calculated on the government’s total unbudgeted pharmaceutical spending or on specific product sales thresholds and we apply an estimated allocation factor against our actual invoiced sales to project the expected level of reimbursement. We obtain third-party information that helps us to monitor the adequacy of these accruals.
•Provisions for pharmaceutical chargebacks (primarily reimbursements to U.S. wholesalers for honoring contracted prices and legislated discounts to third parties) closely approximate actual amounts incurred, as we settle these deductions generally within two to five weeks of incurring the liability.
We recorded direct product sales and/or Alliance revenues of more than $1 billion for each of nine products in 2021, for each of seven products in 2020 and for each of six products in 2019. In the aggregate, these direct products sales and/or alliance product revenues represented 75% of our revenues in 2021, 54% of our revenues in 2020 and 49% of our revenues in 2019. See Note 17B for additional information. The loss or expiration of intellectual property rights can have a significant adverse effect on our revenues as our contracts with customers will generally be at lower selling prices and lower volumes due to added generic competition. We generally provide for higher sales returns during the period in which individual markets begin to near the loss or expiration of intellectual property rights.
Taxes collected from customers relating to product sales and remitted to governmental authorities are excluded from Revenues.Collaborative Arrangements
Payments to and from our collaboration partners are presented in our consolidated statements of income based on the nature of the arrangement (including its contractual terms), the nature of the payments and applicable accounting guidance. Under co-promotion agreements, we record the amounts received for our share of gross profits from our collaboration partners as alliance revenues, a component of Revenues, when our collaboration partners are the principal in the transaction and we receive a share of their net sales or profits. Alliance revenues are recorded as we perform co-promotion activities for the collaboration and the collaboration partners sell the products to their customers. The related expenses for selling and marketing these products including reimbursements to or from our collaboration partners for these costs are included in Selling, informational and administrative expenses. In collaborative arrangements where we manufacture a product for our collaboration partners, we record revenues when we transfer control of the product to our collaboration partners. In collaboration arrangements where we are the principal in the transaction, we record amounts paid to collaboration partners for their share of net sales or profits earned, and all royalty payments to collaboration partners as Cost of sales. Royalty payments received from collaboration partners are included in Other (income)/deductions—net.
Reimbursements to or from our collaboration partners for development costs are typically recorded in Research and development expenses. Upfront payments and pre-approval milestone payments due from us to our collaboration partners in development stage collaborations are recorded as Research and development expenses. Milestone payments due from us to our collaboration partners after regulatory approval has been attained for a medicine are recorded in Identifiable intangible assets—Developed technology rights. Upfront and pre-approval milestone payments earned from our collaboration partners by us are recognized in Other (income)/deductions—net over the development period for the products, when our performance obligations include providing R&D services to our collaboration partners. Upfront, pre-approval and post-approval milestone payments earned by us may be recognized in Other (income)/deductions—net immediately when earned or over other periods depending upon the nature of our performance obligations in the applicable collaboration. Where the milestone event is regulatory approval for a medicine, we generally recognize milestone payments due to us in the transaction price when regulatory approval in the applicable jurisdiction has been attained. We may recognize milestone payments due to us in the transaction price earlier than the milestone event in certain circumstances when recognition of the income would not be probable of a significant reversal.
Trade Accounts Receivable
Trade Accounts Receivable—Trade accounts receivable are stated at their net realizable value. The allowance for credit losses reflects our best estimate of expected credit losses of the receivables portfolio determined on the basis of historical experience, current information, and forecasts of future economic conditions. In developing the estimate for expected credit losses, trade accounts receivables are segmented into pools of assets depending on market (U.S. versus international), delinquency status, and customer type (high risk versus low risk and government versus non-government), and fixed reserve percentages are established for each pool of trade accounts receivables.

In determining the reserve percentages for each pool of trade accounts receivables, we considered our historical experience with certain customers and customer types, regulatory and legal environments, country and political risk, and other relevant current and future forecasted macroeconomic factors. These credit risk indicators are monitored on a quarterly basis to determine whether there have been any changes in the economic environment that would indicate the established reserve percentages should be adjusted, and are considered on a regional basis to reflect more geographic-specific metrics. Additionally, write-offs and recoveries of customer receivables are tracked against collections on a quarterly basis to determine whether the reserve percentages remain appropriate. When management becomes aware of certain customer-specific factors that impact credit risk, specific allowances for these known troubled accounts are recorded. Trade accounts receivable are written off after all reasonable means to collect the full amount (including litigation, where appropriate) have been exhausted.
During 2021 and 2020, additions to the allowance for credit losses, write-offs and recoveries of customer receivables were not material to our consolidated financial statements.
Cost of Sales and Inventories Cost of Sales and InventoriesInventories are recorded at the lower of cost or net realizable value. The cost of finished goods, work in process and raw materials is determined using average actual cost. We regularly review our inventories for impairment and reserves are established when necessary.
Selling, Informational and Administrative Expenses Selling, Informational and Administrative ExpensesSelling, informational and administrative costs are expensed as incurred. Among other things, these expenses include the internal and external costs of marketing, advertising, shipping and handling, information technology and legal defense.
Research and Development Expenses Research and Development ExpensesR&D costs are expensed as incurred. These expenses include the costs of our proprietary R&D efforts, as well as costs incurred in connection with certain licensing arrangements. Before a compound receives regulatory approval, we record upfront and milestone payments we make to third parties under licensing arrangements as expense. Upfront payments are recorded when incurred, and milestone payments are recorded when the specific milestone has been achieved. Once a compound receives regulatory approval, we record any milestone payments in Identifiable intangible assets, less accumulated amortization and, unless the asset is determined to have an indefinite life, we typically amortize the payments on a straight-line basis over the remaining agreement term or the expected product life cycle, whichever is shorter.
Property, Plant and Equipment Property, plant and equipment, less accumulated depreciation—These assets are recorded at cost, including any significant improvements after purchase, less accumulated depreciation. Property, plant and equipment assets, other than land and construction in progress, are depreciated on a straight-line basis over the estimated useful life of the individual assets. Depreciation begins when the asset is ready for its intended use. For tax purposes, accelerated depreciation methods are used as allowed by tax laws.
Intangible Assets and Goodwill Identifiable intangible assets, less accumulated amortization—These assets are recorded at fair value at acquisition. Intangible assets with finite lives are amortized on a straight-line basis over their estimated useful lives. Intangible assets with indefinite lives are not amortized until a useful life can be determined.
•Goodwill—Goodwill represents the excess of the consideration transferred for an acquired business over the assigned values of its net assets. Goodwill is not amortized.
Amortization of finite-lived acquired intangible assets that contribute to our ability to sell, manufacture, research, market and distribute products, compounds and intellectual property is included in Amortization of intangible assets as these intangible assets benefit multiple business functions. Amortization of intangible assets that are for a single function and depreciation of property, plant and equipment are included in Cost of sales, Selling, informational and administrative expenses and/or Research and development expenses, as appropriate.
Specifically:
•For finite-lived intangible assets, such as developed technology rights, and for other long-lived assets, such as property, plant and equipment, whenever impairment indicators are present, we calculate the undiscounted value of the projected cash flows for the asset, or asset group, and compare this estimated amount to the carrying amount. If the carrying amount is greater, we record an impairment loss for the excess of book value over fair value. In addition, in all cases of an impairment review, we reevaluate the remaining useful lives of the assets and modify them, as appropriate.
•For indefinite-lived intangible assets, such as brands and IPR&D assets, when necessary, we determine the fair value of the asset and record an impairment loss, if any, for the excess of book value over fair value. In addition, in all cases of an impairment review other than for IPR&D assets, we re-evaluate whether continuing to characterize the asset as indefinite-lived is appropriate.
•For goodwill, when necessary, we determine the fair value of each reporting unit and record an impairment loss, if any, for the excess of the book value of the reporting unit over the implied fair value.
Property, Plant and Equipment, Impairment We review our long-lived assets for impairment indicators throughout the year. We perform impairment testing for indefinite-lived intangible assets and goodwill at least annually and for all other long-lived assets whenever impairment indicators are present. When necessary, we record impairments of long-lived assets for the amount by which the fair value is less than the carrying value of these assets.
Restructuring Charges and Other Costs Associated with Acquisitions and Cost-Reduction/Productivity Initiatives Restructuring Charges and Other Costs Associated with Acquisitions and Cost-Reduction/Productivity Initiatives
We may incur restructuring charges in connection with acquisitions when we implement plans to restructure and integrate the acquired operations or in connection with our cost-reduction and productivity initiatives.
•In connection with acquisition activity, we typically incur costs associated with executing the transactions, integrating the acquired operations (which may include expenditures for consulting and the integration of systems and processes), and restructuring the combined company (which may include charges related to employees, assets and activities that will not continue in the combined company); and
•In connection with our cost-reduction/productivity initiatives, we typically incur costs and charges for site closings and other facility rationalization actions, workforce reductions and the expansion of shared services, including the development of global systems.
Included in Restructuring charges and certain acquisition-related costs are all restructuring charges, as well as certain other costs associated with acquiring and integrating an acquired business. If the restructuring action results in a change in the estimated useful life of an asset, that incremental impact is classified in Cost of sales, Selling, informational and administrative expenses and/or Research and development expenses, as appropriate. Employee termination costs are generally recorded when the actions are probable and estimable and include accrued severance benefits, pension and postretirement benefits, many of which may be paid out during periods after termination. Transaction costs, such as banking, legal, accounting and other similar costs incurred in connection with a business acquisition are expensed as incurred.
Our business and platform functions may be impacted by these actions, including sales and marketing, manufacturing and R&D, as well as our corporate enabling functions (such as digital, global real estate operations, legal, finance, human resources, worldwide public affairs, compliance and worldwide procurement).
Cash Equivalents Cash equivalents include items almost as liquid as cash, such as certificates of deposit and time deposits with maturity periods of three months or less when purchased. If items meeting this definition are part of a larger investment pool, we classify them as Short-term investments.
Statement of Cash Flows Cash flows for financial instruments designated as fair value or cash flow hedges may be included in operating, investing or financing activities, depending on the classification of the items being hedged. Cash flows for financial instruments designated as net investment hedges are classified according to the nature of the hedging instrument. Cash flows for financial instruments that do not qualify for hedge accounting treatment are classified according to their purpose and accounting nature.
Investments Investments and Derivative Financial Instruments
The classification of an investment depends on the nature of the investment, our intent and ability to hold the investment, and the degree to which we may exercise influence. Our investments are primarily comprised of the following:
•Public equity securities with readily determinable fair values, which are carried at fair value, with changes in fair value reported in Other (income)/deductions—net.
•Available-for-sale debt securities, which are carried at fair value, with changes in fair value reported in Other comprehensive income/(loss) until realized.
•Held-to-maturity debt securities, which are carried at amortized cost.
•Private equity securities without readily determinable fair values and where we have no significant influence are measured at cost minus any impairment and plus or minus changes resulting from observable price changes in orderly transactions for the identical or a similar investment of the same issuer.
•For equity investments in common stock or in-substance common stock where we have significant influence over the financial and operating policies of the investee, we use the equity-method of accounting. Under the equity-method, we record our share of the investee’s income and expenses in Other (income)/deductions—net. The excess of the cost of the investment over our share of the underlying equity in the net assets of the investee as of the acquisition date is allocated to the identifiable assets and liabilities of the investee, with any remaining excess amount allocated to goodwill. Such investments are initially recorded at cost, which is the fair value of consideration paid and typically does not include contingent consideration.

Realized gains or losses on sales of investments are determined by using the specific identification cost method.

We regularly evaluate all of our financial assets for impairment. For investments in debt and equity, when a decline in fair value, if any, is determined, an impairment charge is recorded and a new cost basis in the investment is established.
Derivative Financial Instruments Derivative financial instruments are carried at fair value in various balance sheet categories (see Note 7A), with changes in fair value reported in Net income or, for derivative financial instruments in certain qualifying hedging relationships, in Other comprehensive income/(loss)
Tax Assets and Liabilities and Income Tax Contingencies Tax Assets and Liabilities and Income Tax Contingencies
Tax Assets and Liabilities

Current tax assets primarily include (i) tax effects for intercompany transfers of inventory within our combined group, which are recognized in the consolidated statements of income when the inventory is sold to a third party and (ii) income tax receivables that are expected to be recovered either via refunds from taxing authorities or reductions to future tax obligations.

Deferred tax assets and liabilities are recognized for the expected future tax consequences of differences between the financial reporting and tax bases of assets and liabilities using enacted tax rates and laws. We provide a valuation allowance when we believe that our deferred tax assets are not recoverable based on an assessment of estimated future taxable income that incorporates ongoing, prudent and feasible tax-planning strategies, that would be implemented, if necessary, to realize the deferred tax assets. Amounts recorded for valuation allowances requires judgments about future income which can depend heavily on estimates and assumptions. All deferred tax assets and liabilities within the same tax jurisdiction are presented as a net amount in the noncurrent section of our consolidated balance sheet.
The TCJA subjects a U.S. shareholder to current tax on global intangible low-taxed income earned by certain foreign subsidiaries. The FASB Staff Q&A, Topic 740, No. 5, Accounting for Global Intangible Low-Taxed Income, states that we are permitted to make an accounting policy election to either recognize deferred taxes for temporary basis differences expected to reverse as global intangible low-taxed income in future years or provide for the tax expense related to such income in the year the tax is incurred. We elected to recognize deferred taxes for temporary differences expected to reverse as global intangible low-taxed income in future years.

Other non-current tax assets primarily represent our estimate of the potential tax benefits in one tax jurisdiction that could result from the payment of income taxes in another tax jurisdiction. These potential benefits generally result from cooperative efforts among taxing authorities, as required by tax treaties to minimize double taxation, commonly referred to as the competent authority process. The recoverability of these assets, which we believe to be more likely than not, is dependent upon the actual payment of taxes in one tax jurisdiction and, in some cases, the successful petition for recovery in another tax jurisdiction.

Other taxes payable as of December 31, 2021 and 2020 include liabilities for uncertain tax positions and the noncurrent portion of the repatriation tax liability for which we elected payment over eight years through 2026. For additional information, see Note 5D for uncertain tax positions and Note 5A for the repatriation tax liability and other estimates and assumptions in connection with the TCJA.

Income Tax Contingencies

We account for income tax contingencies using a benefit recognition model. If we consider that a tax position is more likely than not to be sustained upon audit, based solely on the technical merits of the position, we recognize all or a portion of the benefit. We measure the benefit by determining the amount that is greater than 50% likely of being realized upon settlement, presuming that the tax position is examined by the taxing authority with full knowledge of all relevant information.
We regularly monitor our position and subsequently recognize the unrecognized tax benefit: (i) if there are changes in tax law, analogous case law or there is new information that sufficiently raise the likelihood of prevailing on the technical merits of the position to “more likely than not”; (ii) if the statute of limitations expires; or (iii) if there is a completion of an audit resulting in a favorable settlement of that tax year with the appropriate agency. Liabilities for uncertain tax positions are classified as current only when we expect to pay cash within the next 12 months. Interest and penalties, if any, are recorded in Provision/(benefit) for taxes on income and are classified on our consolidated balance sheet with the related tax liability.

Our assessments are based on estimates and assumptions that have been deemed reasonable by management, but our estimates of unrecognized tax benefits and potential tax benefits may not be representative of actual outcomes, and variation from such estimates could materially affect our financial statements in the period of settlement or when the statutes of limitations expire, as we treat these events as discrete items in the period of resolution.
Pension and Postretirement Benefit Plans Pension and Postretirement Benefit PlansThe majority of our employees worldwide are covered by defined benefit pension plans, defined contribution plans or both. In the U.S., we have both IRC-qualified and supplemental (non-qualified) defined benefit plans and defined contribution plans, as well as other postretirement benefit plans consisting primarily of medical insurance for retirees and their eligible dependents. We recognize the overfunded or underfunded status of each of our defined benefit plans as an asset or liability. The obligations are generally measured at the actuarial present value of all benefits attributable to employee service rendered, as provided by the applicable benefit formula. Our pension and other postretirement obligations may be determined using assumptions such as discount rate, expected annual rate of return on plan assets, expected employee turnover and participant mortality. For our pension plans, the obligation may also include assumptions as to future compensation levels. For our other postretirement benefit plans, the obligation may include assumptions as to the expected cost of providing medical insurance benefits, as well as the extent to which those costs are shared with the employee or others (such as governmental programs). Plan assets are measured at fair value. Net periodic pension and postretirement benefit costs other than the service costs are recognized in Other (income)/deductions—net.
Legal and Environmental Contingencies Legal and Environmental ContingenciesWe and certain of our subsidiaries are subject to numerous contingencies arising in the ordinary course of business, such as patent litigation, product liability and other product-related litigation, commercial litigation, environmental claims and proceedings, government investigations and guarantees and indemnifications. In assessing contingencies related to legal and environmental proceedings that are pending against the Company, or unasserted claims that are probable of being asserted, we record accruals for these contingencies to the extent that we conclude that a loss is both probable and reasonably estimable. If some amount within a range of loss appears to be a better estimate than any other amount within the range, we accrue that amount. Alternatively, when no amount within a range of loss appears to be a better estimate than any other amount, we accrue the lowest amount in the range. We record anticipated recoveries under existing insurance contracts when recovery is assured.
Share-Based Payments Share-Based PaymentsOur compensation programs can include share-based payments. Generally, grants under share-based payment programs are accounted for at fair value and these fair values are generally amortized on a straight-line basis over the vesting terms with the related costs recorded in Cost of sales, Selling, informational and administrative expenses and/or Research and development expenses, as appropriate.
Leases
We lease real estate, fleet, and equipment for use in our operations. Our leases generally have lease terms of 1 to 30 years, some of which include options to terminate or extend leases for up to 5 to 10 years or on a month-to-month basis. We include options that are reasonably certain to be exercised as part of the determination of lease terms. We may negotiate termination clauses in anticipation of any changes in market conditions, but generally these termination options have not been exercised. Residual value guarantees are generally not included within our operating leases with the exception of some fleet leases. In addition to base rent payments, the leases may require us to pay directly for taxes and other non-lease components, such as insurance, maintenance and other operating expenses, which may be dependent on usage or vary month-to-month. Variable lease payments amounted to $381 million in 2021, $380 million in 2020 and $326 million in 2019. We elected the practical expedient to not separate non-lease components from lease components in calculating the amounts of ROU assets and lease liabilities for all underlying asset classes.
We determine if an arrangement is a lease at inception of the contract and we perform the lease classification test as of the lease commencement date. ROU assets represent our right to use an underlying asset for the lease term and lease liabilities represent our obligation to make lease payments arising from the lease. Operating lease ROU assets and liabilities are recognized at commencement date based on the present value of lease payments over the lease term. As most of our leases do not provide an implicit rate, we use our estimated incremental borrowing rate based on the information available at commencement date in determining the present value of future payments.
v3.22.0.1
Basis of Presentation and Significant Accounting Policies (Tables)
 12 Months Ended
Dec. 31, 2021
Organization, Consolidation and Presentation of Financial Statements [Abstract]  
Summary of Change in Accounting Principle
The impacts of the adjustments on our consolidated financial statements are summarized as follows:
 Year Ended December 31,
202120202019
(MILLIONS, EXCEPT PER COMMON SHARE DATA)Previous
Accounting
Principle		Impact of ChangeAs ReportedPrevious Accounting PrincipleImpact of ChangeAs AdjustedPrevious Accounting PrincipleImpact of ChangeAs Adjusted
Consolidated Statements of Income:
(Gain) on completion of Consumer Healthcare JV transaction$— $— $— $(6)$— $(6)$(8,086)$(21)$(8,107)
Other (income)/deductions––net(2,820)(2,058)(4,878)672 547 1,219 3,264 233 3,497 
Income from continuing operations before provision/(benefit) for taxes on income22,253 2,058 24,311 7,584 (547)7,036 11,533 (212)11,321 
Provision/(benefit) for taxes on income1,399 453 1,852 496 (125)370 631 (48)583 
Discontinued operations––net of tax(434)— (434)2,564 (35)2,529 5,400 (82)5,318 
Net income before allocation to noncontrolling interests20,420 1,605 22,025 9,652 (457)9,195 16,302 (246)16,056 
Net income attributable to Pfizer Inc. common shareholders20,374 1,605 21,979 9,616 (457)9,159 16,273 (246)16,026 
Earnings per common share––basic:
Income from continuing operations attributable to Pfizer Inc. common shareholders$3.71 $0.29 $4.00 $1.27 $(0.08)$1.19 $1.95 $(0.03)$1.92 
Discontinued operations––net of tax(0.08)— (0.08)0.46 (0.01)0.46 0.97 (0.01)0.95 
Net income attributable to Pfizer Inc. common shareholders3.63 0.29 3.92 1.73 (0.08)1.65 2.92 (0.04)2.88 
Earnings per common share––diluted:
Income from continuing operations attributable to Pfizer Inc. common shareholders$3.65 $0.28 $3.93 $1.25 $(0.07)$1.18 $1.92 $(0.03)$1.89 
Discontinued operations––net of tax(0.08)— (0.08)0.46 (0.01)0.45 0.95 (0.01)0.94 
Net income attributable to Pfizer Inc. common shareholders3.57 0.28 3.85 1.71 (0.08)1.63 2.87 (0.04)2.82 
 Year Ended December 31,
202120202019
(MILLIONS)Previous
Accounting
Principle		Impact of ChangeAs ReportedPrevious Accounting PrincipleImpact of ChangeAs AdjustedPrevious Accounting PrincipleImpact of ChangeAs Adjusted
Consolidated Statements of Comprehensive Income:
Foreign currency translation adjustments, net$(731)$49 $(682)$957 $(185)$772 $654 $21 $675 
Benefit plans: actuarial gains/(losses), net1,565 (1,565)— (1,128)1,128 — (826)826 — 
Reclassification adjustments related to amortization285 (285)— 276 (276)— 241 (241)— 
Reclassification adjustments related to settlements, net209 (209)— 278 (278)— 274 (274)— 
Other49 (49)— (189)189 — 22 (22)— 
Tax provision/(benefit) on other comprehensive income/(loss)545 (475)71 (349)122 (227)115 63 178 
Consolidated Statements of Cash Flows:
Deferred taxes from continuing operations$(4,746)$453 $(4,293)$(1,449)$(125)$(1,575)$609 $(48)$561 
Benefit plan contributions in excess of expense/income(1,065)(2,058)(3,123)(1,790)547 (1,242)(288)233 (55)
 Year Ended December 31,
20212020
(MILLIONS)Previous
Accounting
Principle		Impact of ChangeAs ReportedPrevious Accounting PrincipleImpact of ChangeAs Adjusted
Consolidated Balance Sheets:
Noncurrent deferred tax assets and other noncurrent tax assets$3,320 $22 $3,341 $2,383 $— $2,383 
Other noncurrent assets7,679 — 7,679 4,879 — 4,879 
Pension benefit obligations3,489 — 3,489 4,766 — 4,766 
Retained earnings101,789 1,605 103,394 96,770 (6,378)90,392 
Accumulated other comprehensive loss(4,313)(1,583)(5,897)(11,688)6,378 (5,310)
Information About Balance Sheet Classification of Accruals
Our accruals for Medicare, Medicaid and related state program and performance-based contract rebates, chargebacks, sales allowances and sales returns and cash discounts are as follows:
  As of December 31,
(MILLIONS)20212020
Reserve against Trade accounts receivable, less allowance for doubtful accounts
$1,077 $861 
Other current liabilities:
Accrued rebates3,811 3,017 
Other accruals528 432 
Other noncurrent liabilities
433 399 
Total accrued rebates and other sales-related accruals$5,850 $4,708 
v3.22.0.1
Acquisitions, Divestitures, Equity-Method Investments, Licensing Arrangements and Collaborative Arrangements (Tables)
 12 Months Ended
Dec. 31, 2021
Business Combinations, Discontinued Operations And Disposal Groups, Collaborative Arrangements And Equity Method Investments [Abstract]  
Summarized Financial Information of Discontinued Operations
Components of Discontinued operations––net of tax:
Year Ended December 31,(a)
(MILLIONS)202120202019
Revenues$277 $7,572 $10,845 
Costs and expenses:
Cost of sales204 2,106 2,173 
Selling, informational and administrative expenses26 1,682 1,624 
Research and development expenses9 224 265 
Amortization of intangible assets 45 224 181 
Restructuring charges and certain acquisition-related costs2 29 146 
Other (income)/deductions––net365 428 401 
Pre-tax income/(loss) from discontinued operations(375)2,879 6,056 
Provision/(benefit) for taxes on income(107)349 738 
Income/(loss) from discontinued operations––net of tax(268)2,529 5,318 
Pre-tax loss on sale of discontinued operations(211)— — 
Benefit for taxes on income(44)— — 
Loss on sale of discontinued operations––net of tax(167)— — 
Discontinued operations––net of tax$(434)$2,529 $5,318 
(a)In 2021, Discontinued operations—net of tax primarily includes (i) the operations of Meridian prior to its sale on December 31, 2021 recognized in Income/(loss) from discontinued operations—net of tax, which includes a pre-tax amount for a Multi-District Litigation relating to EpiPen against the Company in the U.S. District Court for the District of Kansas for $345 million; and (ii) the after tax loss of $167 million related to the sale of Meridian recognized in Loss on sale of discontinued operations––net of tax. To a much lesser extent, Discontinued operations—net of tax in 2021 also includes the operations of the Mylan-Japan collaboration prior to its termination on December 21, 2020 and post-closing adjustments directly related to our former Upjohn and Nutrition discontinued businesses, including adjustments for tax, benefits and legal-related matters recognized in Income/(loss) from discontinued operations—net of tax. In 2020 and 2019, Discontinued operations—net of tax relates to the operations of the Upjohn Business, Meridian and the Mylan-Japan collaboration and includes the change in accounting principle in the first quarter of 2021 to MTM Accounting. See Note 1C. In 2020, Discontinued operations—net of tax includes pre-tax interest expense of $116 million associated with the U.S. dollar and Euro denominated senior unsecured notes issued by Upjohn Inc. and Upjohn Finance B.V. in the second quarter of 2020 and pre-tax charges of $223 million related to the remeasurement of Euro debt issued by Upjohn Finance B.V. in the second quarter of 2020.
Components of assets and liabilities of discontinued operations and other assets held for sale:
As of December 31,(a)
(MILLIONS)20212020
Current assets of discontinued operations and other assets held for sale––Other current assets
$25 $215 
Property, plant and equipment$— $155 
Identifiable intangible assets— 134 
Other noncurrent assets— 29 
Noncurrent assets of discontinued operations––Other noncurrent assets
$— $319 
Current liabilities of discontinued operations––Other current liabilities
$— $74 
Noncurrent liabilities of discontinued operations––Other noncurrent liabilities
$— $16 
(a)Amounts as of December 31, 2021 represent property, plant and equipment held for sale. Amounts as of December 31, 2020 primarily relate to discontinued operations of our former Meridian subsidiary and the Mylan-Japan collaboration.
Summarized Financial Information of Equity Method Investments
Summarized financial information for our equity method investee, the Consumer Healthcare JV, as of September 30, 2021, the most recent period available, and as of September 30, 2020 and for the periods ending September 30, 2021, 2020, and 2019 is as follows:
(MILLIONS)September 30, 2021September 30, 2020
Current assets$6,890 $6,614 
Noncurrent assets39,445 38,361 
Total assets
$46,335 $44,975 
Current liabilities$5,133 $5,246 
Noncurrent liabilities5,218 5,330 
Total liabilities
$10,351 $10,576 
Equity attributable to shareholders$35,705 $34,154 
Equity attributable to noncontrolling interests279 245 
Total net equity$35,984 $34,400 
For the Twelve Months EndingFor the Two Months Ending
(MILLIONS)September 30, 2021September 30, 2020September 30, 2019
Net sales$12,836 $12,720 $2,161 
Cost of sales(4,755)(5,439)(803)
Gross profit$8,081 $7,281 $1,358 
Income from continuing operations1,614 1,350 152 
Net income1,614 1,350 152 
Income attributable to shareholders1,547 1,307 148 
Summarized financial information for our equity method investee, ViiV, as of December 31, 2021 and 2020 and for the years ending December 31, 2021, 2020, and 2019 is as follows:
As of December 31,
(MILLIONS)20212020
Current assets$3,608 $3,283 
Noncurrent assets3,563 3,381 
Total assets
$7,171 $6,664 
Current liabilities$3,497 $3,028 
Noncurrent liabilities6,536 6,370 
Total liabilities
$10,033 $9,398 
Total net equity/(deficit) attributable to shareholders$(2,862)$(2,734)
Year Ended December 31,
(MILLIONS)202120202019
Net sales$6,380 $6,224 $6,139 
Cost of sales(682)(574)(516)
Gross profit$5,698 $5,650 $5,623 
Income from continuing operations2,040 2,012 3,398 
Net income2,040 2,012 3,398 
Income attributable to shareholders2,040 2,012 3,398 
Schedule of Collaborative Arrangements and Non-collaborative Arrangement Transactions
The following provides the amounts and classification of payments (income/(expense)) between us and our collaboration partners:
Year Ended December 31,
(MILLIONS)202120202019
Revenues—Revenues(a)
$590 $284 $305 
Revenues—Alliance revenues(b)
7,652 5,418 4,648 
Total revenues from collaborative arrangements$8,241 $5,703 $4,953 
Cost of sales(c)
$(16,169)$(61)$(52)
Selling, informational and administrative expenses(d)
(175)(194)(176)
Research and development expenses(e)
(742)(192)104 
Other income/(deductions)—net(f)
820 567 362 
(a)Represents sales to our partners of products manufactured by us.
(b)Substantially all relates to amounts earned from our partners under co-promotion agreements. The increase in 2021 reflects increases in alliance revenues from Comirnaty, Eliquis and Xtandi, while the increase in 2020 reflects increases in alliance revenues from Eliquis and Xtandi.
(c)Primarily relates to amounts paid to collaboration partners for their share of net sales or profits earned in collaboration arrangements where we are the principal in the transaction, and cost of sales for inventory purchased from our partners. The increase in 2021 is primarily related to Comirnaty.
(d)Represents net reimbursements to our partners for selling, informational and administrative expenses incurred.
(e)Primarily relates to upfront payments and pre-approval milestone payments earned by our partners as well as net reimbursements.
(f)Primarily relates to royalties from our collaboration partners.
v3.22.0.1
Restructuring Charges and Other Costs Associated with Acquisitions and Cost-Reduction/Productivity Initiatives (Tables)
 12 Months Ended
Dec. 31, 2021
Restructuring and Related Activities [Abstract]  
Schedule Providing Components of Costs Associated with Acquisitions and Cost-Reduction/Productivity Initiatives
The following summarizes acquisitions and cost-reduction/productivity initiatives costs and credits:
Year Ended December 31,
(MILLIONS)202120202019
Restructuring charges/(credits):
Employee terminations$680 $474 $108 
Asset impairments53 66 69 
Exit costs/(credits)8 (6)50 
Restructuring charges/(credits)(a)
741 535 227 
Transaction costs(b)
20 10 63 
Integration costs and other(c)
41 34 311 
Restructuring charges and certain acquisition-related costs
802 579 601 
Net periodic benefit costs/(credits) recorded in Other (income)/deductions––net(d)
(63)3 23 
Additional depreciation––asset restructuring recorded in our consolidated statements of income as follows(e):
Cost of sales63 21 29 
Selling, informational and administrative expenses23 — 3 
Research and development expenses— (3)8 
Total additional depreciation––asset restructuring
87 17 40 
Implementation costs recorded in our consolidated statements of income as follows(f):
Cost of sales45 40 61 
Selling, informational and administrative expenses426 197 73 
Research and development expenses1 1 22 
Total implementation costs
472 238 156 
Total costs associated with acquisitions and cost-reduction/productivity initiatives$1,298 $838 $820 
(a)Represents acquisition-related costs ($9 million credit in 2021 and $192 million credit in 2019) and cost reduction initiatives ($750 million charge in 2021, $535 million charge in 2020, and $418 million charge in 2019). 2021 and 2020 charges mainly represent employee termination costs for our Transforming to a More Focused Company cost-reduction program. 2019 restructuring charges mainly represent employee termination costs for cost-reduction and productivity initiatives, partially offset by the reversal of certain accruals related to our acquisition of Wyeth upon the effective favorable settlement of an IRS audit for multiple tax years (see Note 5B). The employee termination costs for 2019 were primarily for our improvements to operational effectiveness as part of the realignment of our business structure, and also included employee termination costs for the Transforming to a More Focused Company cost-reduction program.
(b)Represents external costs for banking, legal, accounting and other similar services.
(c)Represents external, incremental costs directly related to integrating acquired businesses, such as expenditures for consulting and the integration of systems and processes, and certain other qualifying costs. 2021 costs primarily related to our acquisition of Trillium. 2020 costs primarily related to our acquisition of Array. 2019 costs mainly related to our acquisitions of Array, including $157 million in payments to Array employees for the fair value of previously unvested stock options that was recognized as post-closing compensation expense (see Note 2A), and Hospira.
(d)Amounts include the impact of a change in accounting principle. See Note 1C.
(e)Represents the impact of changes in the estimated useful lives of assets involved in restructuring actions.
(f)Represents external, incremental costs directly related to implementing our non-acquisition-related cost-reduction/productivity initiatives.
Schedule of Restructuring Reserve by Type of Cost
The following summarizes the components and changes in restructuring accruals:
(MILLIONS)Employee
Termination
Costs		Asset
Impairment
Charges		Exit CostsAccrual
Balance, January 1, 2020
$770 $— $46 $816 
Provision474 66 (6)535 
Utilization and other(a)
(462)(66)(25)(554)
Balance, December 31, 2020(b)
782 — 15 798 
Provision680 53 8 741 
Utilization and other(a)
(449)(53)34 (468)
Balance, December 31, 2021(c)
$1,014 $— $57 $1,071 
(a)Includes adjustments for foreign currency translation.
(b)Included in Other current liabilities ($628 million) and Other noncurrent liabilities ($169 million).
(c)Included in Other current liabilities ($816 million) and Other noncurrent liabilities ($255 million).
v3.22.0.1
Other (Income)/Deductions - Net (Tables)
 12 Months Ended
Dec. 31, 2021
Other Income and Expenses [Abstract]  
Schedule of Other Nonoperating Income (Expense)
Components of Other (income)/deductions––net include:
Year Ended December 31,
(MILLIONS)202120202019
Interest income$(36)$(73)$(225)
Interest expense(a)
1,291 1,449 1,573 
Net interest expense
1,255 1,376 1,348 
Royalty-related income(857)(770)(646)
Net (gains)/losses on asset disposals(99)237 (32)
Net (gains)/losses recognized during the period on equity securities(b)
(1,344)(540)(454)
Income from collaborations, out-licensing arrangements and sales of compound/product rights(c)
(396)(326)(168)
Net periodic benefit costs/(credits) other than service costs(d)
(2,547)311 305 
Certain legal matters, net(e)
182 28 292 
Certain asset impairments(f)
86 1,691 2,792 
Business and legal entity alignment costs(g)
— — 300 
Consumer Healthcare JV equity method (income)/loss(h)
(471)(298)(17)
Other, net(i)
(687)(491)(224)
Other (income)/deductions––net
$(4,878)$1,219 $3,497 
(a)Capitalized interest totaled $108 million in 2021, $96 million in 2020 and $88 million in 2019.
(b)2021 gains include, among other things, unrealized gains of $1.6 billion related to investments in BioNTech and Cerevel. 2020 gains included, among other things, unrealized gains of $405 million related to investments in BioNTech and SpringWorks Therapeutics, Inc. (SpringWorks). 2019 gains included, among other things, unrealized gains of $295 million related to investments in Cortexyme, Inc. and SpringWorks.
(c)2021 includes, among other things, $188 million of net collaboration income from BioNTech related to the COVID-19 vaccine and $97 million of milestone income from multiple licensees. 2020 included, among other things, (i) a $75 million upfront payment received from our sale of our CK1 assets to Biogen, (ii) $40 million of milestone income from Puma Biotechnology, Inc. related to Neratinib regulatory approvals in the EU, (iii) $30 million of milestone income from Lilly related to the first commercial sale in the U.S. of LOXO-292 for the treatment of RET fusion-positive NSCLC and (iv) $108 million in milestone income from multiple licensees. 2019 included, among other things, $78 million in milestone income from Mylan Pharmaceuticals Inc. related to the FDA’s approval and launch of Wixela Inhub®, a generic of Advair Diskus®(fluticasone propionate and salmeterol inhalation powder) and $52 million in milestone income from multiple licensees.
(d)Amounts include the impact of a change in accounting principle. See Notes 1C and 11. In 2019, other non-service cost components’ activity related to the Consumer Healthcare JV transaction, such as gain on settlements, were recorded in (Gain) on completion of Consumer Healthcare JV transaction.
(e)Includes legal reserves for certain pending legal matters.
(f)2020 represents intangible asset impairment charges associated with our Biopharma segment: (i) $900 million related to IPR&D assets for unapproved indications of certain cancer medicines, acquired in our Array acquisition, and reflected, among other things, updated commercial forecasts; (ii) $528 million related to Eucrisa, a finite-lived developed technology right acquired in our Anacor acquisition, and reflected updated commercial forecasts mainly reflecting competitive pressures; and (iii) $263 million related to finite-lived developed technology rights for certain generic sterile injectables acquired in our Hospira acquisition, and reflected updated commercial forecasts mainly reflecting competitive pressures.
2019 primarily included intangible asset impairment charges of $2.8 billion, mainly composed of $2.6 billion, related to Eucrisa, and reflected updated commercial forecasts mainly reflecting competitive pressures.
(g)Mainly represents incremental costs for the design, planning and implementation of our then new business structure, effective in the beginning of 2019, and primarily includes consulting, legal, tax and other advisory services.
(h)See Note 2C.
(i)2021 includes, among other things, (i) income net of costs associated with TSAs of $288 million; (ii) dividend income of $166 million from our investment in ViiV and (iii) charges of $142 million, reflecting the change in the fair value of contingent consideration. 2020 included, among other things, (i) dividend income of $278 million from our investment in ViiV; (ii) income net of costs associated with TSAs of $114 million and (iii) charges of $105 million, reflecting the change in the fair value of contingent consideration. 2019 included, among other things, (i) dividend income of $220 million from our investment in ViiV; (ii) charges of $152 million for external incremental costs, such as transaction costs and costs to separate our Consumer Healthcare business into a separate legal entity, associated with the formation of the Consumer Healthcare JV; and (iii) net losses on early retirement of debt of $138 million.
v3.22.0.1
Tax Matters (Tables)
 12 Months Ended
Dec. 31, 2021
Income Tax Disclosure [Abstract]  
Schedule of Income before Income Tax, Domestic and Foreign
Components of Income from continuing operations before provision/(benefit) for taxes on income include:
 Year Ended December 31,
(MILLIONS)202120202019
United States$6,064 $(2,887)$7,332 
International18,247 9,924 3,988 
Income from continuing operations before provision/(benefit) for taxes on income(a), (b)
$24,311 $7,036 $11,321 
(a)2021 v. 2020––The domestic income in 2021 versus domestic loss in 2020 was mainly related to Comirnaty income, lower asset impairment charges, net periodic benefit credits in 2021 versus net periodic benefit costs in 2020 and higher net gains from equity securities, partially offset by higher R&D expenses. The increase in the international income was primarily related to Comirnaty income, net periodic benefit credits in 2021 versus net periodic benefit costs in 2020 and lower asset impairment charges.
(b)2020 v. 2019––The domestic loss in 2020 versus domestic income in 2019 was mainly related to the non-recurrence of the gain on the completion of the Consumer Healthcare JV transaction as well as higher asset impairment charges and higher R&D expenses. The increase in the international income was primarily related to the non-recurrence of the write off of assets contributed to the Consumer Healthcare JV as well as lower asset impairment charges and lower amortization of intangible assets.
Schedule of Provision for Taxes on Income
Components of Provision/(benefit) for taxes on income based on the location of the taxing authorities include:
 Year Ended December 31,
(MILLIONS)202120202019
United States
Current income taxes:
Federal
$3,342 $372 $(1,887)
State and local
34 56 (186)
Deferred income taxes:
Federal
(3,850)(1,164)1,254 
State and local
(491)(131)276 
Total U.S. tax benefit
(964)(867)(543)
TCJA
Current income taxes
— — (135)
Deferred Income taxes
— — (187)
Total TCJA tax benefit
— — (323)
International
Current income taxes
2,769 1,517 2,418 
Deferred income taxes
48 (279)(969)
Total international tax provision
2,816 1,237 1,449 
Provision/(benefit) for taxes on income
$1,852 $370 $583 
Schedule of Effective Income Tax Rate Reconciliation
The reconciliation of the U.S. statutory income tax rate to our effective tax rate for Income from continuing operations follows:
 Year Ended December 31,
202120202019
U.S. statutory income tax rate21.0 %21.0 %21.0 %
TCJA impact(a)
— — (2.9)
Taxation of non-U.S. operations (b), (c)
(4.3)(9.9)(4.7)
Tax settlements and resolution of certain tax positions(a)
(0.4)(2.7)(14.0)
Completion of Consumer Healthcare JV transaction(a)
— — 8.3 
Certain Consumer Healthcare JV initiatives(a)
(6.0)— — 
U.S. R&D tax credit(0.5)(1.4)(0.8)
Interest(d)
0.4 1.1 0.6 
All other, net(e)
(2.6)(2.8)(2.3)
Effective tax rate for income from continuing operations
7.6 %5.3 %5.2 %
(a)See Note 5A.
(b)For taxation of non-U.S. operations, this rate impact reflects the income tax rates and relative earnings in the locations where we do business outside the U.S., together with the U.S. tax cost on our international operations, changes in uncertain tax positions not included in the reconciling item called “Tax settlements and resolution of certain tax positions,” as well as changes in valuation allowances. Specifically: (i) the jurisdictional location of earnings is a significant component of our effective tax rate each year, and the rate impact of this component is influenced by the specific location of non-U.S. earnings and the level of such earnings as compared to our total earnings; (ii) the U.S. tax implications of our foreign operations is a significant component of our effective tax rate each year and generally offsets some of the reduction to our effective tax rate each year resulting from the jurisdictional location of earnings; (iii) the impact of certain tax initiatives; and (iv) the impact of changes in uncertain tax positions not included in the reconciling item called “Tax settlements and resolution of certain tax positions” is a component of our effective tax rate each year that can result in either an increase or decrease to our effective tax rate. The jurisdictional mix of earnings, which includes the impact of the location of earnings as well as the U.S. tax cost on our international operations, can vary as a result of operating fluctuations in the normal course of business and as a result of the extent and location of other income and expense items, such as restructuring charges, asset impairments and gains and losses on strategic business decisions. See also Note 5A for the components of pre-tax income and Provision/(benefit) for taxes on income, which is based on the location of the taxing authorities, and for information about settlements and other items impacting Provision/(benefit) for taxes on income.
(c)In all years, the reduction in our effective tax rate is a result of the jurisdictional location of earnings and is largely due to lower tax rates in certain jurisdictions, as well as manufacturing and other incentives for our subsidiaries in Singapore and, to a lesser extent, in Puerto Rico. We benefit from Puerto Rican tax incentives pursuant to a grant that expires during 2029. Under such grant, we are partially exempt from income, property and municipal taxes. In Singapore, we benefit from incentive tax rates effective through 2047 on income from manufacturing and other operations.
(d)Includes changes in interest related to our uncertain tax positions not included in the reconciling item called “Tax settlements and resolution of certain tax positions”.
(e)All other, net is primarily due to routine business operations.
Schedule of Deferred Tax Assets and Liabilities
Components of our deferred tax assets and liabilities, shown before jurisdictional netting, follow:
2021 Deferred Tax*2020 Deferred Tax*
(MILLIONS)Assets(Liabilities)Assets(Liabilities)
Prepaid/deferred items(a)
$4,086 $(456)$3,114 $(336)
Inventories408 (56)276 (25)
Intangible assets(b)
1,778 (4,577)793 (5,355)
Property, plant and equipment(c)
117 (1,647)211 (1,220)
Employee benefits(d)
1,594 (178)1,981 (124)
Restructurings and other charges303 — 291 — 
Legal and product liability reserves373 — 382 — 
Net operating loss/tax credit carryforwards(e)
1,431 — 1,761 — 
Unremitted earnings— (45)— (46)
State and local tax adjustments197 — 171 — 
Investments(f)
70 (689)130 (3,545)
All other89 (68)80 (76)
10,446 (7,714)9,190 (10,726)
Valuation allowances(1,462)— (1,586)— 
Total deferred taxes$8,983 $(7,714)$7,604 $(10,726)
Net deferred tax asset/(liability)(g)
$1,269 $(3,123)
*The deferred tax assets and liabilities associated with global intangible low-taxed income are included in the relevant categories. See Note 1Q.
(a)The increase in net deferred tax assets in 2021 is primarily related to temporary differences associated with Comirnaty royalty accruals and the result of operating lease ROU liabilities recognized during the period.
(b)The increase in the deferred tax assets is primarily due to the acquisition of intangible assets relating to Trillium and the decrease in the 2021 deferred tax liabilities is primarily the result of amortization of intangible assets.
(c)The increase in net deferred tax liabilities in 2021 is primarily the result of operating lease ROU assets recognized during the period. See Note 15.
(d)The decrease in net deferred tax assets in 2021 is primarily the result of favorable pension plan asset performance reported in the period. See Note 11A.
(e)The amounts in 2021 and 2020 are reduced for unrecognized tax benefits of $3.0 billion and $3.0 billion, respectively, where we have net operating loss carryforwards, similar tax losses, and/or tax credit carryforwards that are available, under the tax law of the applicable jurisdiction, to settle any additional income taxes that would result from the disallowance of a tax position.
(f)The decrease in net deferred tax liabilities in 2021 is primarily due to certain initiatives executed in the third quarter of 2021 associated with our investment in the Consumer Healthcare JV.
(g)In 2021, Noncurrent deferred tax assets and other noncurrent tax assets ($1.6 billion), and Noncurrent deferred tax liabilities ($0.3 billion). In 2020, Noncurrent deferred tax assets and other noncurrent tax assets ($0.9 billion), and Noncurrent deferred tax liabilities ($4.1 billion).
Schedule of Unrecognized Tax Benefits Roll Forward
The reconciliation of the beginning and ending amounts of gross unrecognized tax benefits follows:
(MILLIONS)202120202019
Balance, beginning$(5,595)$(5,381)$(6,259)
Acquisitions— 37 (44)
Divestitures(a)
— 265 — 
Increases based on tax positions taken during a prior period(b)
(111)(232)(36)
Decreases based on tax positions taken during a prior period(b), (c)
103 64 1,109 
Decreases based on settlements for a prior period(d)
24 15 100 
Increases based on tax positions taken during the current period(b)
(550)(411)(383)
Impact of foreign exchange22 (72)25 
Other, net(b), (e)
40 120 107 
Balance, ending(f)
$(6,068)$(5,595)$(5,381)
(a)For 2020, related to the separation of Upjohn. See Note 2B.
(b)Primarily included in Provision/(benefit) for taxes on income.
(c)Primarily related to effectively settling certain issues with the U.S. and foreign tax authorities. See Note 5A.
(d)Primarily related to cash payments and reductions of tax attributes.
(e)Primarily related to decreases as a result of a lapse of applicable statutes of limitations.
(f)In 2021, included in Income taxes payable ($19 million), Other current assets ($42 million) Noncurrent deferred tax assets and other noncurrent tax assets ($3.0 billion), Noncurrent deferred tax liabilities ($5 million) and Other taxes payable ($3.0 billion). In 2020, included in Income taxes payable ($34 million), Noncurrent deferred tax assets and other noncurrent tax assets ($18 million), Noncurrent deferred tax liabilities ($3.0 billion) and Other taxes payable ($2.5 billion).
Schedule of Other Comprehensive Income (Loss), Components of Income Tax Expense (Benefit)
Components of the Tax provision/(benefit) on other comprehensive income/(loss) include:
 Year Ended December 31,
(MILLIONS)202120202019
Foreign currency translation adjustments, net(a)
$43 $(119)$260 
Unrealized holding gains/(losses) on derivative financial instruments, net84 (88)83 
Reclassification adjustments for (gains)/losses included in net income29 (25)(125)
 114 (113)(42)
Unrealized holding gains/(losses) on available-for-sale securities, net(44)45 — 
Reclassification adjustments for (gains)/losses included in net income(4)(24)5 
 (48)22 5 
Benefit plans: prior service (costs)/credits and other, net27 12 (1)
Reclassification adjustments related to amortization of prior service costs and other, net(47)(31)(43)
Reclassification adjustments related to curtailments of prior service costs and other, net(17)— (1)
Other(1)1 — 
 (38)(17)(45)
Tax provision/(benefit) on other comprehensive income/(loss)$71 $(227)$178 
(a)Taxes are not provided for foreign currency translation adjustments relating to investments in international subsidiaries that are expected to be held indefinitely.
v3.22.0.1
Accumulated Other Comprehensive Loss, Excluding Noncontrolling Interests (Tables)
 12 Months Ended
Dec. 31, 2021
Equity [Abstract]  
Schedule of Changes in Accumulated Other Comprehensive Loss, Net of Tax
The following summarizes the changes, net of tax, in Accumulated other comprehensive loss(a):
Net Unrealized Gains/(Losses)Benefit Plans
(MILLIONS)Foreign Currency Translation Adjustments Derivative Financial InstrumentsAvailable-For-Sale SecuritiesPrior Service (Costs)/ Credits and OtherAccumulated Other Comprehensive Income/(Loss)
Balance, January 1, 2019$(6,075)$167 $(68)$728 $(5,249)
Other comprehensive income/(loss)(b)
139 (146)33 (144)(118)
Balance, December 31, 2019(5,936)20 (35)584 (5,367)
Other comprehensive income/(loss)(b)
883 (448)151 (106)480 
Distribution of Upjohn Business(c)
(397)— — (26)(423)
Balance, December 31, 2020(5,450)(428)116 452 (5,310)
Other comprehensive income/(loss)(b)
(722)547 (336)(75)(587)
Balance, December 31, 2021$(6,172)$119 $(220)$377 $(5,897)
(a)Amounts include the impact of a change in accounting principle. See Note 1C.
(b)Amounts do not include foreign currency translation adjustments attributable to noncontrolling interests. Foreign currency translation adjustments include net losses in 2021 and net gains in 2020 and 2019 related to our equity-method investment in the Consumer Healthcare JV (see Note 2C), and the impact of our net investment hedging program.
(c)For more information, see Note 2B.
v3.22.0.1
Financial Instruments (Tables)
 12 Months Ended
Dec. 31, 2021
Financial Instruments [Abstract]  
Schedule of Fair Value, Assets and Liabilities Measured on Recurring Basis
Financial Assets and Liabilities Measured at Fair Value on a Recurring Basis and Fair Value Hierarchy, using a Market Approach:
As of December 31, 2021As of December 31, 2020
(MILLIONS)TotalLevel 1Level 2TotalLevel 1Level 2
Financial assets:
Short-term investments
Classified as equity securities with readily determinable fair values:
Money market funds$5,365 $— $5,365 $567 $— $567 
Classified as available-for-sale debt securities:
Government and agency—non-U.S.17,318 — 17,318 7,719 — 7,719 
Government and agency—U.S.4,050 — 4,050 982 — 982 
Corporate and other647 — 647 1,008 — 1,008 
22,014 — 22,014 9,709 — 9,709 
Total short-term investments27,379 — 27,379 10,276 — 10,276 
Other current assets
Derivative assets:
Interest rate contracts4 — 4 18 — 18 
Foreign exchange contracts704 — 704 234 — 234 
Total other current assets709 — 709 251 — 251 
Long-term investments
Classified as equity securities with readily determinable fair values(a)
3,876 3,849 27 2,809 2,776 32 
Classified as available-for-sale debt securities:
Government and agency—non-U.S.465 — 465 6 — 6 
Government and agency—U.S.6 — 6 121 — 121 
Corporate and other50 — 50 — — — 
521 — 521 128 — 128 
Total long-term investments4,397 3,849 548 2,936 2,776 160 
Other noncurrent assets
Derivative assets:
Interest rate contracts16 — 16 117 — 117 
Foreign exchange contracts242 — 242 5 — 5 
Total derivative assets259 — 259 122 — 122 
Insurance contracts(b)
808 — 808 693 — 693 
Total other noncurrent assets1,067 — 1,067 814 — 814 
Total assets$33,552 $3,849 $29,703 $14,278 $2,776 $11,501 
Financial liabilities:
Other current liabilities
Derivative liabilities:
Foreign exchange contracts$476 $— $476 $501 $— $501 
Total other current liabilities476 — 476 501 — 501 
Other noncurrent liabilities
Derivative liabilities:
Foreign exchange contracts405 — 405 599 — 599 
Total other noncurrent liabilities405 — 405 599 — 599 
Total liabilities$881 $— $881 $1,100 $— $1,100 
(a)Long-term equity securities of $194 million as of December 31, 2021 and $190 million as of December 31, 2020 were held in restricted trusts for U.S. non-qualified employee benefit plans.
(b)Includes life insurance policies held in restricted trusts for U.S. non-qualified employee benefit plans. The underlying invested assets in these contracts are marketable securities, which are carried at fair value, with changes in fair value recognized in Other (income)/deductions—net (see Note 4).
Summary of Investments
The following summarizes our investments by classification type:
As of December 31,
(MILLIONS)20212020
Short-term investments
Equity securities with readily determinable fair values(a)
$5,365 $567 
Available-for-sale debt securities22,014 9,709 
Held-to-maturity debt securities1,746 161 
Total Short-term investments$29,125 $10,437 
Long-term investments
Equity securities with readily determinable fair values$3,876 $2,809 
Available-for-sale debt securities521 128 
Held-to-maturity debt securities34 37 
Private equity securities at cost(b)
623 432 
Total Long-term investments
$5,054 $3,406 
Equity-method investments16,472 16,856 
Total long-term investments and equity-method investments
$21,526 $20,262 
Held-to-maturity cash equivalents$268 $89 
(a)As of December 31, 2021 and 2020, includes money market funds primarily invested in U.S. Treasury and government debt.
(b)Represent investments in the life sciences sector.
Contractual Maturities of Available-for-sale and Held-to-maturity Securities
At December 31, 2021, our investment portfolio consisted of debt securities issued across diverse governments, corporate and financial institutions, which are investment-grade. The contractual or estimated maturities, are as follows:
As of December 31, 2021As of December 31, 2020
Gross UnrealizedMaturities (in Years)Gross Unrealized
(MILLIONS)Amortized CostGainsLossesFair ValueWithin 1Over 1
to 5		Over 5Amortized CostGainsLossesFair Value
Available-for-sale debt securities
Government and agency––non-U.S.
$18,032 $13 $(263)$17,783 $17,318 $465 $— $7,593 $136 $(4)$7,725 
Government and agency––U.S.
4,056 — (1)4,055 4,050 6 — 1,104 — (1)1,103 
Corporate and other698 — (1)697 647 50 — 1,006 2 — 1,008 
Held-to-maturity debt securities
Time deposits and other
947 — — 947 917 18 11 283 — — 283 
Government and agency––non-U.S.
1,102 — — 1,102 1,097 4 1 5 — — 5 
Total debt securities$24,835 $14 $(265)$24,584 $24,029 $543 $13 $9,991 $138 $(5)$10,124 
Schedule of Available-for-sale Securities Reconciliation
At December 31, 2021, our investment portfolio consisted of debt securities issued across diverse governments, corporate and financial institutions, which are investment-grade. The contractual or estimated maturities, are as follows:
As of December 31, 2021As of December 31, 2020
Gross UnrealizedMaturities (in Years)Gross Unrealized
(MILLIONS)Amortized CostGainsLossesFair ValueWithin 1Over 1
to 5		Over 5Amortized CostGainsLossesFair Value
Available-for-sale debt securities
Government and agency––non-U.S.
$18,032 $13 $(263)$17,783 $17,318 $465 $— $7,593 $136 $(4)$7,725 
Government and agency––U.S.
4,056 — (1)4,055 4,050 6 — 1,104 — (1)1,103 
Corporate and other698 — (1)697 647 50 — 1,006 2 — 1,008 
Held-to-maturity debt securities
Time deposits and other
947 — — 947 917 18 11 283 — — 283 
Government and agency––non-U.S.
1,102 — — 1,102 1,097 4 1 5 — — 5 
Total debt securities$24,835 $14 $(265)$24,584 $24,029 $543 $13 $9,991 $138 $(5)$10,124 
Held-to-maturity Securities
At December 31, 2021, our investment portfolio consisted of debt securities issued across diverse governments, corporate and financial institutions, which are investment-grade. The contractual or estimated maturities, are as follows:
As of December 31, 2021As of December 31, 2020
Gross UnrealizedMaturities (in Years)Gross Unrealized
(MILLIONS)Amortized CostGainsLossesFair ValueWithin 1Over 1
to 5		Over 5Amortized CostGainsLossesFair Value
Available-for-sale debt securities
Government and agency––non-U.S.
$18,032 $13 $(263)$17,783 $17,318 $465 $— $7,593 $136 $(4)$7,725 
Government and agency––U.S.
4,056 — (1)4,055 4,050 6 — 1,104 — (1)1,103 
Corporate and other698 — (1)697 647 50 — 1,006 2 — 1,008 
Held-to-maturity debt securities
Time deposits and other
947 — — 947 917 18 11 283 — — 283 
Government and agency––non-U.S.
1,102 — — 1,102 1,097 4 1 5 — — 5 
Total debt securities$24,835 $14 $(265)$24,584 $24,029 $543 $13 $9,991 $138 $(5)$10,124 
Schedule of Gains and Losses on Investment Securities
The following presents the calculation of the portion of unrealized (gains)/losses that relates to equity securities, excluding equity method investments, held at the reporting date:
Year Ended December 31,
(MILLIONS)202120202019
Net (gains)/losses recognized during the period on equity securities(a)
$(1,344)$(540)$(454)
Less: Net (gains)/losses recognized during the period on equity securities sold during the period(80)(24)(25)
Net unrealized (gains)/losses during the reporting period on equity securities still held at the reporting date(b)
$(1,264)$(515)$(429)
(a)Reported in Other (income)/deductions––net. See Note 4.
(b)Included in net unrealized gains are observable price changes on equity securities without readily determinable fair values. As of December 31, 2021, there were cumulative impairments and downward adjustments of $97 million and upward adjustments of $156 million. Impairments, downward and upward adjustments were not significant in 2021, 2020 and 2019.
Schedule of Short-term Borrowings
Short-term borrowings include:
As of December 31,
(MILLIONS)20212020
Commercial paper $— $556 
Current portion of long-term debt, principal amount1,636 2,004 
Other short-term borrowings, principal amount(a)
605 145 
Total short-term borrowings, principal amount
2,241 2,705 
Net unamortized discounts, premiums and debt issuance costs— (2)
Total Short-term borrowings, including current portion of long-term debt, carried at historical proceeds, as adjusted
$2,241 $2,703 
(a)Primarily includes cash collateral. See Note 7F.
Schedule of Long-term Debt Instruments
The following outlines our senior unsecured long-term debt and the weighted-average stated interest rate by maturity:
As of December 31,
(MILLIONS)20212020
Notes due 2022 (1.0% for 2020)(a)
$— $1,728 
Notes due 2023 (3.2% for 2021 and 2020)
2,550 2,550 
Notes due 2024 (3.9% for 2021 and 2020)
2,250 2,250 
Notes due 2025 (0.8% for 2021 and 2020)
750 750 
Notes due 2026 (2.9% for 2021 and 2020)
3,000 3,000 
Notes due 2027 (2.1% for 2021 and 2.0% for 2020)
1,051 1,121 
Notes due 2028-2032 (3.1% for 2021 and 3.4% for 2020)
6,660 5,660 
Notes due 2033-2037 (5.6% for 2021 and 2020)
4,250 4,250 
Notes due 2038-2042 (5.5% for 2021 and 2020)
6,079 6,086 
Notes due 2043-2047 (3.7% for 2021 and 2020)
4,858 4,878 
Notes due 2048-2050 (3.6% for 2021 and 2020)
3,500 3,500 
Total long-term debt, principal amount34,948 35,774 
Net fair value adjustments related to hedging and purchase accounting1,438 1,562 
Net unamortized discounts, premiums and debt issuance costs(195)(207)
Other long-term debt4 4 
Total long-term debt, carried at historical proceeds, as adjusted$36,195 $37,133 
Current portion of long-term debt, carried at historical proceeds, as adjusted (not included above (1.0% for 2021 and 2.6% for 2020))
$1,636 $2,002 
(a)Reclassified to the current portion of long-term debt.
Our long-term debt outlined in the above table is generally redeemable by us at any time at varying redemption prices plus accrued and unpaid interest.
Issuances
In August 2021, we issued the following senior unsecured notes at an effective interest rate of 1.79%:
(MILLIONS)Principal
Interest RateMaturity Date
As of
December 31, 2021
1.750%(a)
August 18, 2031
$1,000 
(a)The notes may be redeemed by us at any time, in whole, or in part, at a redemption price plus accrued and unpaid interest.
Schedule of Derivative Financial Instruments
The following summarizes the fair value of the derivative financial instruments and notional amounts (including those reported as part of discontinued operations):
(MILLIONS)As of December 31, 2021As of December 31, 2020
Fair ValueFair Value
NotionalAssetLiabilityNotionalAssetLiability
Derivatives designated as hedging instruments:
Foreign exchange contracts(a)
$29,576 $787 $717 $24,369 $145 $1,005 
Interest rate contracts
2,250 21 — 1,950 135 — 
808 717 280 1,005 
Derivatives not designated as hedging instruments:
Foreign exchange contracts
$21,419 160 164 $15,063 94 95 
Total$968 $881 $373 $1,100 
(a)The notional amount of outstanding foreign exchange contracts hedging our intercompany forecasted inventory sales was $4.8 billion as of December 31, 2021 and $5.0 billion as of December 31, 2020.
Schedule of Derivative Assets at Fair Value
The following summarizes the fair value of the derivative financial instruments and notional amounts (including those reported as part of discontinued operations):
(MILLIONS)As of December 31, 2021As of December 31, 2020
Fair ValueFair Value
NotionalAssetLiabilityNotionalAssetLiability
Derivatives designated as hedging instruments:
Foreign exchange contracts(a)
$29,576 $787 $717 $24,369 $145 $1,005 
Interest rate contracts
2,250 21 — 1,950 135 — 
808 717 280 1,005 
Derivatives not designated as hedging instruments:
Foreign exchange contracts
$21,419 160 164 $15,063 94 95 
Total$968 $881 $373 $1,100 
(a)The notional amount of outstanding foreign exchange contracts hedging our intercompany forecasted inventory sales was $4.8 billion as of December 31, 2021 and $5.0 billion as of December 31, 2020.
Schedule of Derivative Liabilities at Fair Value
The following summarizes the fair value of the derivative financial instruments and notional amounts (including those reported as part of discontinued operations):
(MILLIONS)As of December 31, 2021As of December 31, 2020
Fair ValueFair Value
NotionalAssetLiabilityNotionalAssetLiability
Derivatives designated as hedging instruments:
Foreign exchange contracts(a)
$29,576 $787 $717 $24,369 $145 $1,005 
Interest rate contracts
2,250 21 — 1,950 135 — 
808 717 280 1,005 
Derivatives not designated as hedging instruments:
Foreign exchange contracts
$21,419 160 164 $15,063 94 95 
Total$968 $881 $373 $1,100 
(a)The notional amount of outstanding foreign exchange contracts hedging our intercompany forecasted inventory sales was $4.8 billion as of December 31, 2021 and $5.0 billion as of December 31, 2020.
Schedule of Gains/(Losses) Incurred to Hedge or Offset Operational Foreign Exchange or Interest Rate Risk
The following summarizes information about the gains/(losses) incurred to hedge or offset operational foreign exchange or interest rate risk exposures (including those reported as part of discontinued operations):
 

Gains/(Losses)
Recognized in OID(a)
Gains/(Losses)
Recognized in OCI(a)
Gains/(Losses)
Reclassified from
OCI into OID and COS(a)
Year Ended December 31,
(MILLIONS)202120202021202020212020
Derivative Financial Instruments in Cash Flow Hedge Relationships:
      
Foreign exchange contracts(b)
$— $— $488 $(649)$(173)$(77)
Amount excluded from effectiveness testing and amortized into earnings(c)
— — 38 55 38 57 
Derivative Financial Instruments in Fair Value Hedge Relationships:
Interest rate contracts
(7)369 — — — — 
Hedged item
7 (369)— — — — 
Derivative Financial Instruments in Net Investment Hedge Relationships:
Foreign exchange contracts— — 468 (501)— — 
Amount excluded from effectiveness testing and amortized into earnings(c)
— — 52 181 109 154 
Non-Derivative Financial Instruments in Net Investment Hedge Relationships:(d)
Foreign currency short-term borrowings— — 78 8 — — 
Foreign currency long-term debt— — 86 (183)— — 
Derivative Financial Instruments Not Designated as Hedges:
Foreign exchange contracts(192)178 — — — — 
All other net(c)
— — 1 12 1 (1)
$(192)$178 $1,210 $(1,077)$(25)$133 
(a)OID = Other (income)/deductions—net, included in Other (income)/deductions—net in the consolidated statements of income. COS = Cost of Sales, included in Cost of sales in the consolidated statements of income. OCI = Other comprehensive income/(loss), included in the consolidated statements of comprehensive income.
(b)The amounts reclassified from OCI into COS were:
•a net loss of $89 million in 2021; and
•a net gain of $172 million in 2020 (including a gain of $22 million reported in Discontinued operations––net of tax).
The remaining amounts were reclassified from OCI into OID. Based on year-end foreign exchange rates that are subject to change, we expect to reclassify a pre-tax gain of $362 million within the next 12 months into income. The maximum length of time over which we are hedging our exposure to the variability in future foreign exchange cash flows is approximately 21 years and relates to foreign currency debt.
(c)The amounts reclassified from OCI were reclassified into OID.
(d)Short-term borrowings and long-term debt include foreign currency borrowings which are used as net investment hedges. The short-term borrowings carrying value as of December 31, 2021 was $1.1 billion. The long-term debt carrying values as of December 31, 2021 and December 31, 2020 were $844 million and $2.1 billion, respectively.
Schedule of Amounts Recorded In Balance Sheet Related to Cumulative Adjustments for Fair Value Hedges
The following summarizes cumulative basis adjustments to our long-term debt in fair value hedges:
As of December 31, 2021As of December 31, 2020
Cumulative Amount of Fair
Value Hedging Adjustment
Increase/(Decrease) to
Carrying Amount		Cumulative Amount of Fair
Value Hedging Adjustment Increase/(Decrease) to
Carrying Amount
(MILLIONS)
Carrying Amount of Hedged Assets/Liabilities(a)
Active
Hedging
Relationships		Discontinued Hedging Relationships
Carrying Amount of Hedged Assets/Liabilities(a)
Active Hedging RelationshipsDiscontinued Hedging Relationships
Long-term debt$2,233 $16 $1,154 $2,016 $117 $1,149 
(a)Carrying amounts exclude the cumulative amount of fair value hedging adjustments.
Schedule of Amounts Recorded In Balance Sheet Related to Cumulative Adjustments for Cash Flow Hedges
The following summarizes cumulative basis adjustments to our long-term debt in fair value hedges:
As of December 31, 2021As of December 31, 2020
Cumulative Amount of Fair
Value Hedging Adjustment
Increase/(Decrease) to
Carrying Amount		Cumulative Amount of Fair
Value Hedging Adjustment Increase/(Decrease) to
Carrying Amount
(MILLIONS)
Carrying Amount of Hedged Assets/Liabilities(a)
Active
Hedging
Relationships		Discontinued Hedging Relationships
Carrying Amount of Hedged Assets/Liabilities(a)
Active Hedging RelationshipsDiscontinued Hedging Relationships
Long-term debt$2,233 $16 $1,154 $2,016 $117 $1,149 
(a)Carrying amounts exclude the cumulative amount of fair value hedging adjustments.
v3.22.0.1
Other Financial Information (Tables)
 12 Months Ended
Dec. 31, 2021
Other Financial Information [Abstract]  
Schedule of Components of Inventories, Current
The following summarizes the components of Inventories:
As of December 31,
(MILLIONS)20212020
Finished goods$3,641 $2,867 
Work in process4,424 4,436 
Raw materials and supplies994 716 
Inventories(a)
$9,059 $8,020 
Noncurrent inventories not included above(b)
$939 $890 
(a)The change from December 31, 2020 reflects increases for certain products, including inventory build for new product launches (primarily Comirnaty), network strategy and supply recovery, partially offset by decreases due to market demand.
(b)Included in Other noncurrent assets. There are no recoverability issues for these amounts.
Schedule of Component of Inventories, Noncurrent
The following summarizes the components of Inventories:
As of December 31,
(MILLIONS)20212020
Finished goods$3,641 $2,867 
Work in process4,424 4,436 
Raw materials and supplies994 716 
Inventories(a)
$9,059 $8,020 
Noncurrent inventories not included above(b)
$939 $890 
(a)The change from December 31, 2020 reflects increases for certain products, including inventory build for new product launches (primarily Comirnaty), network strategy and supply recovery, partially offset by decreases due to market demand.
(b)Included in Other noncurrent assets. There are no recoverability issues for these amounts.
v3.22.0.1
Property, Plant and Equipment (PP&E) (Tables)
 12 Months Ended
Dec. 31, 2021
Property, Plant and Equipment [Abstract]  
Schedule of Components of Property, Plant and Equipment
The following summarizes the components of Property, plant and equipment:
 Useful LivesAs of December 31,
(MILLIONS)(Years)  20212020
Land-$423 $443 
Buildings
33-50
9,001 8,998 
Machinery and equipment
8-20
12,252 11,000 
Furniture, fixtures and other
3-12.5
4,457 4,484 
Construction in progress-3,822 3,481 
29,955 28,406 
Less: Accumulated depreciation15,074 14,661 
Property, plant and equipment$14,882 $13,745 
Long-lived Assets by Geographic Areas
The following provides long-lived assets by geographic area:
 As of December 31,
(MILLIONS)20212020
Property, plant and equipment
United States$8,385 $7,666 
Developed Europe5,094 4,775 
Developed Rest of World347 413 
Emerging Markets1,056 890 
Property, plant and equipment$14,882 $13,745 
v3.22.0.1
Identifiable Intangible Assets and Goodwill (Tables)
 12 Months Ended
Dec. 31, 2021
Goodwill and Intangible Assets Disclosure [Abstract]  
Schedule of Finite-Lived Intangible Assets
The following summarizes the components of Identifiable intangible assets:
 As of December 31, 2021As of December 31, 2020
(MILLIONS)Gross
Carrying
Amount		Accumulated
Amortization		Identifiable
Intangible
Assets, less
Accumulated
Amortization		Gross
Carrying
Amount		Accumulated
Amortization		Identifiable
Intangible
Assets, less
Accumulated
Amortization
Finite-lived intangible assets
Developed technology rights(a)
$73,346 $(53,732)$19,614 $73,040 $(50,532)$22,508 
Brands922 (807)115 922 (774)148 
Licensing agreements and other2,284 (1,299)985 2,292 (1,187)1,106 
76,552 (55,838)20,714 76,255 (52,493)23,762 
Indefinite-lived intangible assets
Brands827 827 827 827 
IPR&D3,092 3,092 3,175 3,175 
Licensing agreements and other513 513 573 573 
4,432 4,432 4,575 4,575 
Identifiable intangible assets(b)
$80,984 $(55,838)$25,146 $80,830 $(52,493)$28,337 
(a)The increase in the gross carrying amount primarily reflects $500 million of capitalized Comirnaty sales milestones to BioNTech, partially offset by net losses from foreign currency translation adjustments.
(b)The decrease is primarily due to amortization, partially offset by the capitalization of the Comirnaty milestones described above.
Schedule of Indefinite-Lived Intangible Assets
The following summarizes the components of Identifiable intangible assets:
 As of December 31, 2021As of December 31, 2020
(MILLIONS)Gross
Carrying
Amount		Accumulated
Amortization		Identifiable
Intangible
Assets, less
Accumulated
Amortization		Gross
Carrying
Amount		Accumulated
Amortization		Identifiable
Intangible
Assets, less
Accumulated
Amortization
Finite-lived intangible assets
Developed technology rights(a)
$73,346 $(53,732)$19,614 $73,040 $(50,532)$22,508 
Brands922 (807)115 922 (774)148 
Licensing agreements and other2,284 (1,299)985 2,292 (1,187)1,106 
76,552 (55,838)20,714 76,255 (52,493)23,762 
Indefinite-lived intangible assets
Brands827 827 827 827 
IPR&D3,092 3,092 3,175 3,175 
Licensing agreements and other513 513 573 573 
4,432 4,432 4,575 4,575 
Identifiable intangible assets(b)
$80,984 $(55,838)$25,146 $80,830 $(52,493)$28,337 
(a)The increase in the gross carrying amount primarily reflects $500 million of capitalized Comirnaty sales milestones to BioNTech, partially offset by net losses from foreign currency translation adjustments.
(b)The decrease is primarily due to amortization, partially offset by the capitalization of the Comirnaty milestones described above.
Schedule of Expected Amortization Expense
The following provides the expected annual amortization expense:
(MILLIONS)20222023202420252026
Amortization expense$3,279 $2,936 $2,686 $2,500 $2,449 
Schedule of Goodwill
The following summarizes the components and changes in the carrying amount of Goodwill:
(MILLIONS)
Total(a)
Balance, January 1, 2020
$48,181 
Additions(b)
727 
Other(c)
648 
Balance, December 31, 2020
49,556 
Additions— 
Other(c)
(348)
Balance, December 31, 2021
$49,208 
(a)As a result of the reorganization of our commercial operations during the fourth quarter of 2021 (see Note 17), we were required to estimate the relative fair values of our PC1 and Hospital organizations to determine any reallocation of goodwill. We completed this analysis and determined that no goodwill was required to be reallocated. As a result, our entire goodwill balance continues to be assigned within the Biopharma reportable segment.
(b)Additions primarily represent the impact of measurement period adjustments related to our Array acquisition (see Note 2A).
(c)Other represents the impact of foreign exchange.
v3.22.0.1
Pension and Postretirement Benefit Plans and Defined Contribution Plans (Tables)
 12 Months Ended
Dec. 31, 2021
Retirement Benefits [Abstract]  
Schedule of Net Periodic Benefit Costs
The following summarizes the components of net periodic benefit cost/(credit), including those reported as part of discontinued operations for 2020 and 2019, and the changes in Other comprehensive income/(loss) for our benefit plans:
Pension Plans Postretirement Plans
U.S.International
Year Ended December 31,
(MILLIONS)202120202019202120202019202120202019
Service cost$— $— $— $130 $146 $125 $36 $38 $37 
Interest cost455 533 676 146 164 215 29 49 75 
Expected return on plan assets
(1,052)(1,015)(890)(327)(314)(318)(39)(36)(33)
Amortization of prior service cost/(credit)(2)(3)(4)(1)(3)(4)(151)(170)(173)
Actuarial (gains)/losses(a)
(684)1,152 284 (690)148 669 (167)(165)(118)
Curtailments— — (4)(4)— (1)(82)— (62)
Special termination benefits
17 1 20 — — — 2 — 2 
Net periodic benefit cost/(credit) reported in income(1,265)668 82 (746)141 686 (372)(282)(271)
Cost/(credit) reported in Other comprehensive income/(loss)
2 5 4 4 5 21 107 114 164 
Cost/(credit) recognized in Comprehensive income
$(1,264)$674 $86 $(742)$145 $707 $(265)$(168)$(107)
(a)Reflects actuarial remeasurement gains in 2021, primarily due to favorable plan asset performance and increases in discount rates, and actuarial remeasurement losses in 2020 and 2019, primarily due to decreases in discount rates partially offset by favorable plan asset performance.
Schedule of Assumptions Used
Pension PlansPostretirement Plans
U.S.International
Year Ended December 31,
(PERCENTAGES)202120202019202120202019202120202019
Weighted-average assumptions used to determine net periodic benefit cost:
Discount rate:
Pension plans/postretirement plans2.6 %3.3 %4.4 %2.5 %3.2 %4.3 %
Interest cost1.2 %1.5 %2.2 %
Service cost1.4 %1.6 %2.4 %
Expected return on plan assets6.8 %7.0 %7.2 %3.4 %3.6 %3.9 %6.8 %7.0 %7.3 %
Rate of compensation increase(a)
2.9 %2.9 %1.4 %
Weighted-average assumptions used to determine benefit obligations at fiscal year-end:
Discount rate2.9 %2.6 %3.3 %1.6 %1.5 %1.7 %2.9 %2.5 %3.2 %
Rate of compensation increase(a)
2.8 %2.9 %1.4 %
(a)The rate of compensation increase is not used to determine the net periodic benefit cost and benefit obligation for the U.S. pension plans as these plans are frozen.
Schedule of Health Care Cost Trend Rates
The following provides the healthcare cost trend rate assumptions for our U.S. postretirement benefit plans:
As of December 31,
20212020
Healthcare cost trend rate assumed for next year 6.0 %5.6 %
Rate to which the cost trend rate is assumed to decline4.0 %4.5 %
Year that the rate reaches the ultimate trend rate2045 2037 
Schedule of Analysis of the Changes in the Benefit Obligations, Plan assets and Accounting Funded Status of Pension and Postretirement Benefit Plans
The following provides: (i) an analysis of the changes in our benefit obligations, plan assets and funded status of our benefit plans, including those reported as part of discontinued operations for 2020, (ii) the funded status recognized in our consolidated balance sheets and (iii) the pre-tax components of cumulative amounts recognized in Accumulated other comprehensive loss:
 Pension Plans Postretirement Plans
 U.S. International
Year Ended December 31,
(MILLIONS)202120202021202020212020
Change in benefit obligation(a)
Benefit obligation, beginning$18,306 $17,886 $12,001 $11,059 $1,238 $1,667 
Service cost— — 130 146 36 38 
Interest cost455 533 146 164 29 49 
Employee contributions— — 10 8 78 88 
Plan amendments— 2 — 2 (116)(56)
Changes in actuarial assumptions and other(b)
(331)2,112 89 702 (117)(132)
Foreign exchange impact— — (298)646 1 2 
Upjohn spin-off(c)
— (1,016)3 (320)— (218)
Acquisitions/divestitures/other, net— — — — — — 
Curtailments and special termination benefits17 1 (2)— (8)— 
Settlements(785)(767)(47)(34)— — 
Benefits paid(512)(445)(374)(372)(147)(201)
Benefit obligation, ending(a)
17,150 18,306 11,657 12,001 995 1,238 
Change in plan assets
Fair value of plan assets, beginning
16,094 14,586 9,811 8,956 588 519 
Actual return on plan assets1,405 1,974 1,106 868 89 69 
Company contributions143 1,433 451 197 145 113 
Employee contributions— — 10 8 78 88 
Foreign exchange impact— — (229)462 — — 
Upjohn spin-off(c)
— (687)2 (270)— — 
Acquisitions/divestitures, net— — — (6)— — 
Settlements(785)(767)(47)(34)— — 
Benefits paid(512)(445)(374)(372)(147)(201)
Fair value of plan assets, ending16,346 16,094 10,729 9,811 753 588 
Funded status—Plan assets less than benefit obligation
$(805)$(2,211)$(928)$(2,191)$(241)$(651)
Amounts recorded in our consolidated balance sheet:
Noncurrent assets$447 $— $1,480 $522 $— $— 
Current liabilities(138)(127)(33)(31)(6)(6)
Noncurrent liabilities(1,113)(2,084)(2,376)(2,681)(235)(645)
Funded status$(805)$(2,211)$(928)$(2,191)$(241)$(651)
Pre-tax components of cumulative amounts recognized in Accumulated other comprehensive loss:
Prior service (costs)/credits$(6)$(4)$(35)$(31)$581 $688 
Information related to the funded status of pension plans with an ABO in excess of plan assets(d):
Fair value of plan assets
$120 $16,094 $1,304 $6,674 
ABO1,371 18,306 3,344 8,961 
Information related to the funded status of pension plans with a PBO in excess of plan assets(d):
Fair value of plan assets$120 $16,094 $1,381 $6,735 
PBO1,371 18,306 3,789 9,447 
(a)For the U.S. pension plans, the benefit obligation is both the PBO and ABO as these plans are frozen and future benefit accruals no longer increase with future compensation increases. For the international pension plans, the benefit obligation is the PBO. The ABO for our international pension plans was $11.2 billion in 2021 and $11.5 billion in 2020. For the postretirement plans, the benefit obligation is the ABO.
(b)Primarily includes actuarial gains resulting from increases in discount rates in 2021, offset by increases in inflation assumptions in 2021 for the international plans, and actuarial losses resulting from decreases in discount rates in 2020.
(c)For more information, see Note 2B.
(d)Our main U.S. qualified plan and many of our international plans were overfunded as of December 31, 2021.
Schedule of Amounts Recognized in Balance Sheet
The following provides: (i) an analysis of the changes in our benefit obligations, plan assets and funded status of our benefit plans, including those reported as part of discontinued operations for 2020, (ii) the funded status recognized in our consolidated balance sheets and (iii) the pre-tax components of cumulative amounts recognized in Accumulated other comprehensive loss:
 Pension Plans Postretirement Plans
 U.S. International
Year Ended December 31,
(MILLIONS)202120202021202020212020
Change in benefit obligation(a)
Benefit obligation, beginning$18,306 $17,886 $12,001 $11,059 $1,238 $1,667 
Service cost— — 130 146 36 38 
Interest cost455 533 146 164 29 49 
Employee contributions— — 10 8 78 88 
Plan amendments— 2 — 2 (116)(56)
Changes in actuarial assumptions and other(b)
(331)2,112 89 702 (117)(132)
Foreign exchange impact— — (298)646 1 2 
Upjohn spin-off(c)
— (1,016)3 (320)— (218)
Acquisitions/divestitures/other, net— — — — — — 
Curtailments and special termination benefits17 1 (2)— (8)— 
Settlements(785)(767)(47)(34)— — 
Benefits paid(512)(445)(374)(372)(147)(201)
Benefit obligation, ending(a)
17,150 18,306 11,657 12,001 995 1,238 
Change in plan assets
Fair value of plan assets, beginning
16,094 14,586 9,811 8,956 588 519 
Actual return on plan assets1,405 1,974 1,106 868 89 69 
Company contributions143 1,433 451 197 145 113 
Employee contributions— — 10 8 78 88 
Foreign exchange impact— — (229)462 — — 
Upjohn spin-off(c)
— (687)2 (270)— — 
Acquisitions/divestitures, net— — — (6)— — 
Settlements(785)(767)(47)(34)— — 
Benefits paid(512)(445)(374)(372)(147)(201)
Fair value of plan assets, ending16,346 16,094 10,729 9,811 753 588 
Funded status—Plan assets less than benefit obligation
$(805)$(2,211)$(928)$(2,191)$(241)$(651)
Amounts recorded in our consolidated balance sheet:
Noncurrent assets$447 $— $1,480 $522 $— $— 
Current liabilities(138)(127)(33)(31)(6)(6)
Noncurrent liabilities(1,113)(2,084)(2,376)(2,681)(235)(645)
Funded status$(805)$(2,211)$(928)$(2,191)$(241)$(651)
Pre-tax components of cumulative amounts recognized in Accumulated other comprehensive loss:
Prior service (costs)/credits$(6)$(4)$(35)$(31)$581 $688 
Information related to the funded status of pension plans with an ABO in excess of plan assets(d):
Fair value of plan assets
$120 $16,094 $1,304 $6,674 
ABO1,371 18,306 3,344 8,961 
Information related to the funded status of pension plans with a PBO in excess of plan assets(d):
Fair value of plan assets$120 $16,094 $1,381 $6,735 
PBO1,371 18,306 3,789 9,447 
(a)For the U.S. pension plans, the benefit obligation is both the PBO and ABO as these plans are frozen and future benefit accruals no longer increase with future compensation increases. For the international pension plans, the benefit obligation is the PBO. The ABO for our international pension plans was $11.2 billion in 2021 and $11.5 billion in 2020. For the postretirement plans, the benefit obligation is the ABO.
(b)Primarily includes actuarial gains resulting from increases in discount rates in 2021, offset by increases in inflation assumptions in 2021 for the international plans, and actuarial losses resulting from decreases in discount rates in 2020.
(c)For more information, see Note 2B.
(d)Our main U.S. qualified plan and many of our international plans were overfunded as of December 31, 2021.
Schedule of Amounts Recognized in Accumulated Other Comprehensive Income (Loss)
The following provides: (i) an analysis of the changes in our benefit obligations, plan assets and funded status of our benefit plans, including those reported as part of discontinued operations for 2020, (ii) the funded status recognized in our consolidated balance sheets and (iii) the pre-tax components of cumulative amounts recognized in Accumulated other comprehensive loss:
 Pension Plans Postretirement Plans
 U.S. International
Year Ended December 31,
(MILLIONS)202120202021202020212020
Change in benefit obligation(a)
Benefit obligation, beginning$18,306 $17,886 $12,001 $11,059 $1,238 $1,667 
Service cost— — 130 146 36 38 
Interest cost455 533 146 164 29 49 
Employee contributions— — 10 8 78 88 
Plan amendments— 2 — 2 (116)(56)
Changes in actuarial assumptions and other(b)
(331)2,112 89 702 (117)(132)
Foreign exchange impact— — (298)646 1 2 
Upjohn spin-off(c)
— (1,016)3 (320)— (218)
Acquisitions/divestitures/other, net— — — — — — 
Curtailments and special termination benefits17 1 (2)— (8)— 
Settlements(785)(767)(47)(34)— — 
Benefits paid(512)(445)(374)(372)(147)(201)
Benefit obligation, ending(a)
17,150 18,306 11,657 12,001 995 1,238 
Change in plan assets
Fair value of plan assets, beginning
16,094 14,586 9,811 8,956 588 519 
Actual return on plan assets1,405 1,974 1,106 868 89 69 
Company contributions143 1,433 451 197 145 113 
Employee contributions— — 10 8 78 88 
Foreign exchange impact— — (229)462 — — 
Upjohn spin-off(c)
— (687)2 (270)— — 
Acquisitions/divestitures, net— — — (6)— — 
Settlements(785)(767)(47)(34)— — 
Benefits paid(512)(445)(374)(372)(147)(201)
Fair value of plan assets, ending16,346 16,094 10,729 9,811 753 588 
Funded status—Plan assets less than benefit obligation
$(805)$(2,211)$(928)$(2,191)$(241)$(651)
Amounts recorded in our consolidated balance sheet:
Noncurrent assets$447 $— $1,480 $522 $— $— 
Current liabilities(138)(127)(33)(31)(6)(6)
Noncurrent liabilities(1,113)(2,084)(2,376)(2,681)(235)(645)
Funded status$(805)$(2,211)$(928)$(2,191)$(241)$(651)
Pre-tax components of cumulative amounts recognized in Accumulated other comprehensive loss:
Prior service (costs)/credits$(6)$(4)$(35)$(31)$581 $688 
Information related to the funded status of pension plans with an ABO in excess of plan assets(d):
Fair value of plan assets
$120 $16,094 $1,304 $6,674 
ABO1,371 18,306 3,344 8,961 
Information related to the funded status of pension plans with a PBO in excess of plan assets(d):
Fair value of plan assets$120 $16,094 $1,381 $6,735 
PBO1,371 18,306 3,789 9,447 
(a)For the U.S. pension plans, the benefit obligation is both the PBO and ABO as these plans are frozen and future benefit accruals no longer increase with future compensation increases. For the international pension plans, the benefit obligation is the PBO. The ABO for our international pension plans was $11.2 billion in 2021 and $11.5 billion in 2020. For the postretirement plans, the benefit obligation is the ABO.
(b)Primarily includes actuarial gains resulting from increases in discount rates in 2021, offset by increases in inflation assumptions in 2021 for the international plans, and actuarial losses resulting from decreases in discount rates in 2020.
(c)For more information, see Note 2B.
(d)Our main U.S. qualified plan and many of our international plans were overfunded as of December 31, 2021.
Schedule of Benefit Obligations in Excess of Fair Value of Plan Assets
The following provides: (i) an analysis of the changes in our benefit obligations, plan assets and funded status of our benefit plans, including those reported as part of discontinued operations for 2020, (ii) the funded status recognized in our consolidated balance sheets and (iii) the pre-tax components of cumulative amounts recognized in Accumulated other comprehensive loss:
 Pension Plans Postretirement Plans
 U.S. International
Year Ended December 31,
(MILLIONS)202120202021202020212020
Change in benefit obligation(a)
Benefit obligation, beginning$18,306 $17,886 $12,001 $11,059 $1,238 $1,667 
Service cost— — 130 146 36 38 
Interest cost455 533 146 164 29 49 
Employee contributions— — 10 8 78 88 
Plan amendments— 2 — 2 (116)(56)
Changes in actuarial assumptions and other(b)
(331)2,112 89 702 (117)(132)
Foreign exchange impact— — (298)646 1 2 
Upjohn spin-off(c)
— (1,016)3 (320)— (218)
Acquisitions/divestitures/other, net— — — — — — 
Curtailments and special termination benefits17 1 (2)— (8)— 
Settlements(785)(767)(47)(34)— — 
Benefits paid(512)(445)(374)(372)(147)(201)
Benefit obligation, ending(a)
17,150 18,306 11,657 12,001 995 1,238 
Change in plan assets
Fair value of plan assets, beginning
16,094 14,586 9,811 8,956 588 519 
Actual return on plan assets1,405 1,974 1,106 868 89 69 
Company contributions143 1,433 451 197 145 113 
Employee contributions— — 10 8 78 88 
Foreign exchange impact— — (229)462 — — 
Upjohn spin-off(c)
— (687)2 (270)— — 
Acquisitions/divestitures, net— — — (6)— — 
Settlements(785)(767)(47)(34)— — 
Benefits paid(512)(445)(374)(372)(147)(201)
Fair value of plan assets, ending16,346 16,094 10,729 9,811 753 588 
Funded status—Plan assets less than benefit obligation
$(805)$(2,211)$(928)$(2,191)$(241)$(651)
Amounts recorded in our consolidated balance sheet:
Noncurrent assets$447 $— $1,480 $522 $— $— 
Current liabilities(138)(127)(33)(31)(6)(6)
Noncurrent liabilities(1,113)(2,084)(2,376)(2,681)(235)(645)
Funded status$(805)$(2,211)$(928)$(2,191)$(241)$(651)
Pre-tax components of cumulative amounts recognized in Accumulated other comprehensive loss:
Prior service (costs)/credits$(6)$(4)$(35)$(31)$581 $688 
Information related to the funded status of pension plans with an ABO in excess of plan assets(d):
Fair value of plan assets
$120 $16,094 $1,304 $6,674 
ABO1,371 18,306 3,344 8,961 
Information related to the funded status of pension plans with a PBO in excess of plan assets(d):
Fair value of plan assets$120 $16,094 $1,381 $6,735 
PBO1,371 18,306 3,789 9,447 
(a)For the U.S. pension plans, the benefit obligation is both the PBO and ABO as these plans are frozen and future benefit accruals no longer increase with future compensation increases. For the international pension plans, the benefit obligation is the PBO. The ABO for our international pension plans was $11.2 billion in 2021 and $11.5 billion in 2020. For the postretirement plans, the benefit obligation is the ABO.
(b)Primarily includes actuarial gains resulting from increases in discount rates in 2021, offset by increases in inflation assumptions in 2021 for the international plans, and actuarial losses resulting from decreases in discount rates in 2020.
(c)For more information, see Note 2B.
(d)Our main U.S. qualified plan and many of our international plans were overfunded as of December 31, 2021.
Schedule of Accumulated Benefit Obligations in Excess of Fair Value of Plan Assets
The following provides: (i) an analysis of the changes in our benefit obligations, plan assets and funded status of our benefit plans, including those reported as part of discontinued operations for 2020, (ii) the funded status recognized in our consolidated balance sheets and (iii) the pre-tax components of cumulative amounts recognized in Accumulated other comprehensive loss:
 Pension Plans Postretirement Plans
 U.S. International
Year Ended December 31,
(MILLIONS)202120202021202020212020
Change in benefit obligation(a)
Benefit obligation, beginning$18,306 $17,886 $12,001 $11,059 $1,238 $1,667 
Service cost— — 130 146 36 38 
Interest cost455 533 146 164 29 49 
Employee contributions— — 10 8 78 88 
Plan amendments— 2 — 2 (116)(56)
Changes in actuarial assumptions and other(b)
(331)2,112 89 702 (117)(132)
Foreign exchange impact— — (298)646 1 2 
Upjohn spin-off(c)
— (1,016)3 (320)— (218)
Acquisitions/divestitures/other, net— — — — — — 
Curtailments and special termination benefits17 1 (2)— (8)— 
Settlements(785)(767)(47)(34)— — 
Benefits paid(512)(445)(374)(372)(147)(201)
Benefit obligation, ending(a)
17,150 18,306 11,657 12,001 995 1,238 
Change in plan assets
Fair value of plan assets, beginning
16,094 14,586 9,811 8,956 588 519 
Actual return on plan assets1,405 1,974 1,106 868 89 69 
Company contributions143 1,433 451 197 145 113 
Employee contributions— — 10 8 78 88 
Foreign exchange impact— — (229)462 — — 
Upjohn spin-off(c)
— (687)2 (270)— — 
Acquisitions/divestitures, net— — — (6)— — 
Settlements(785)(767)(47)(34)— — 
Benefits paid(512)(445)(374)(372)(147)(201)
Fair value of plan assets, ending16,346 16,094 10,729 9,811 753 588 
Funded status—Plan assets less than benefit obligation
$(805)$(2,211)$(928)$(2,191)$(241)$(651)
Amounts recorded in our consolidated balance sheet:
Noncurrent assets$447 $— $1,480 $522 $— $— 
Current liabilities(138)(127)(33)(31)(6)(6)
Noncurrent liabilities(1,113)(2,084)(2,376)(2,681)(235)(645)
Funded status$(805)$(2,211)$(928)$(2,191)$(241)$(651)
Pre-tax components of cumulative amounts recognized in Accumulated other comprehensive loss:
Prior service (costs)/credits$(6)$(4)$(35)$(31)$581 $688 
Information related to the funded status of pension plans with an ABO in excess of plan assets(d):
Fair value of plan assets
$120 $16,094 $1,304 $6,674 
ABO1,371 18,306 3,344 8,961 
Information related to the funded status of pension plans with a PBO in excess of plan assets(d):
Fair value of plan assets$120 $16,094 $1,381 $6,735 
PBO1,371 18,306 3,789 9,447 
(a)For the U.S. pension plans, the benefit obligation is both the PBO and ABO as these plans are frozen and future benefit accruals no longer increase with future compensation increases. For the international pension plans, the benefit obligation is the PBO. The ABO for our international pension plans was $11.2 billion in 2021 and $11.5 billion in 2020. For the postretirement plans, the benefit obligation is the ABO.
(b)Primarily includes actuarial gains resulting from increases in discount rates in 2021, offset by increases in inflation assumptions in 2021 for the international plans, and actuarial losses resulting from decreases in discount rates in 2020.
(c)For more information, see Note 2B.
(d)Our main U.S. qualified plan and many of our international plans were overfunded as of December 31, 2021.
Schedule of Allocation of Plan Assets
The following provides the components of plan assets, including those reported as part of discontinued operations for 2020:
As of December 31, 2021As of December 31, 2020
    Fair ValueFair Value
(MILLIONS EXCEPT TARGET ALLOCATION PERCENTAGE)Target Allocation PercentageTotalLevel 1Level
2		Level 3
Assets Measured at NAV(a)
TotalLevel 1Level
 2		Level 3
Assets Measured at NAV(a)
U.S. pension plans
Cash and cash equivalents0-10%$1,326 $78 $1,248 $— $— $781 $70 $711 $— $— 
Equity securities:20-40%
Global equity securities2,273 2,233 38 2 — 3,241 3,213 27 1 — 
Equity commingled funds1,352 — 1,152 — 200 1,325 — 1,110 — 215 
Fixed income securities:45-75%
Corporate debt securities5,566 18 5,548 — — 6,499 23 6,476 — — 
Government and agency obligations(b)
2,533 — 2,533 — — 1,555 — 1,555 — — 
Fixed income commingled funds38 — 38 — — 23 — 23 — — 
Other investments:5-20%
Partnership investments(c)
2,079 3 — — 2,076 1,431 — — — 1,431 
Insurance contracts158 — 158 — — 190 — 190 — — 
Other commingled funds(d)
1,019 — 10 — 1,009 1,049 — 11 — 1,038 
Total100 %$16,346 $2,332 $10,726 $2 $3,286 $16,094 $3,306 $10,103 $1 $2,684 
International pension plans
Cash and cash equivalents0-10%$541 $191 $346 $— $3 $407 $61 $346 $— $— 
Equity securities:10-20%
Equity commingled funds1,453 — 1,386 — 67 2,051 — 1,681 — 370 
Fixed income securities:45-70%
Corporate debt securities1,187 — 1,187 — — 925 — 925 — — 
Government and agency obligations(b)
2,415 — 2,415 — — 1,334 — 1,334 — — 
Fixed income commingled funds2,266 — 1,138 — 1,128 2,484 — 1,217 — 1,267 
Other investments:15-35%
Partnership investments(c)
107 — 2 — 106 69 — 3 — 66 
Insurance contracts1,329 — 56 1,273 — 1,027 — 57 969 1 
Other(d)
1,431 — 141 404 886 1,514 — 117 393 1,003 
Total100 %$10,729 $191 $6,672 $1,677 $2,189 $9,811 $61 $5,681 $1,362 $2,707 
U.S. postretirement plans(e)
Cash and cash equivalents0-5%$85 $3 $82 $— $— $— $— $— $— $— 
Insurance contracts95-100%669 — 669 — — 588 — 588 — — 
Total100 %$753 $3 $750 $— $— $588 $— $588 $— $— 
(a)Certain investments that are measured at NAV per share (or its equivalent) have not been classified in the fair value hierarchy. The NAV amounts presented in this table are intended to permit reconciliation of the fair value hierarchy to the amounts presented for the total pension benefits plan assets.
(b)Government and agency obligations are inclusive of repurchase agreements.
(c)Mainly includes investments in private equity, private debt, public equity limited partnerships, and, to a lesser extent, real estate and venture capital.
(d)Mostly includes investments in hedge funds and real estate.
(e)Reflects postretirement plan assets, which support a portion of our U.S. retiree medical plans.
Schedule of Effect of Significant Unobservable Inputs, Changes in Plan Assets
The following provides an analysis of the changes in our more significant investments valued using significant unobservable inputs, including those reported as part of discontinued operations for 2020:
International Pension Plans
Year Ended December 31,
(MILLIONS)20212020
Fair value, beginning$1,362 $1,342 
Actual return on plan assets:
Assets held, ending23 22 
Purchases, sales, and settlements, net
52 (47)
Transfer into/(out of) Level 3265 (13)
Exchange rate changes(24)58 
Fair value, ending$1,677 $1,362 
Schedule of Expected Future Cash Flow Information
The following provides the expected future cash flow information related to our benefit plans:
  Pension PlansPostretirement Plans
(MILLIONS)U.S.International
Expected employer contributions:
2022$138 $177 $74 
Expected benefit payments:
2022$1,296 $384 $78 
20231,155 372 73 
20241,140 383 69 
20251,089 392 66 
20261,058 397 68 
2027–20314,908 2,124 359 
v3.22.0.1
Equity (Tables)
 12 Months Ended
Dec. 31, 2021
Equity [Abstract]  
Summary of Common Stock Purchases
The following provides the number of shares of our common stock purchased and the cost of purchases under our publicly announced share purchase plans, including our ASR:
Year Ended December 31,
(SHARES IN MILLIONS, DOLLARS IN BILLIONS)
2021
2020
2019(a)
Shares of common stock purchased— — 213 
Cost of purchase$— $— $8.9 
(a)Represents shares purchased pursuant to the ASR with Goldman Sachs & Co. LLC entered into in February 2019, as well as open market share repurchases of $2.1 billion.
v3.22.0.1
Share-Based Payments (Tables)
 12 Months Ended
Dec. 31, 2021
Share-based Payment Arrangement [Abstract]  
Schedule of Share-based Compensation Awards and Valuation Details
A summary of the awards and valuation details:
Awarded toTermsValuationRecognition and Presentation
Total Shareholder Return Units (TSRUs)(a), (b)
Senior and other key management and select employees
•Entitle the holder to receive shares of our common stock with a value equal to the difference between the defined settlement price and the grant price, plus the dividend equivalents accumulated during the five or seven-year term, if and to the extent the total value is positive.
•Settlement price is the average closing price of our common stock during the 20 trading days ending on the fifth or seventh anniversary of the grant, as applicable; the grant price is the closing price of our common stock on the date of the grant.
•Automatically settle on the fifth or seventh anniversary of the grant but vest on the third anniversary of the grant.
As of the grant date using a Monte Carlo simulation model
Amortized on a straight-line basis over the vesting term into Cost of sales, Selling, informational and administrative expenses, and/or Research and development expenses, as appropriate.
Restricted Stock Units (RSUs)
Select employees
•Entitle the holder to receive a specified number of shares of our common stock, including dividend equivalents that are reinvested into additional RSUs.
•For RSUs granted, in virtually all instances, the units vest on the third anniversary of the grant date assuming continuous service from the grant date.
As of the grant date using the closing price of our common stock
Amortized on a straight-line basis over the vesting term into Cost of sales, Selling, informational and administrative expenses, and/or Research and development expenses, as appropriate.
Portfolio Performance Shares (PPSs)
Select employees
•Entitle the holder to receive, at the end of the performance period, shares of our common stock, if any, including shares resulting from dividend equivalents earned on such shares.
•For PPSs granted, the awards vest on the third anniversary of the grant assuming continuous service from the grant date and the number of shares paid, if any, depends on the achievement of predetermined goals related to Pfizer’s long-term product portfolio during a three or five-year performance period from the year of the grant date, as applicable.
•The number of shares that may be earned ranges from 0% to 200% of the initial award depending on goal achievement over the performance period.
As of the grant date using the intrinsic value method using the closing price of our common stock
Amortized on a straight-line basis over the vesting term into Cost of sales, Selling, informational and administrative expenses and/or Research and development expenses, as appropriate, and adjusted each reporting period, as necessary, to reflect changes in the price of our common stock, the number of shares that are probable of being earned, and management’s assessment of the probability that the specified performance criteria will be achieved.
Performance Share Awards (PSAs)
Senior and other key management
•Entitle the holder to receive, at the end of the performance period, shares of our common stock (retirees) earned, if any, or an equal value in cash (active colleagues), including dividend equivalents on shares earned, dependent upon the achievement of predetermined goals related to two measures:
a.Adjusted net income over three one-year periods; and
b.TSR as compared to the NYSE ARCA Pharmaceutical Index (DRG Index) over the three-year performance period.
•PSAs vest on the third anniversary of the grant assuming continuous service from the grant date.
•The award that may be earned ranges from 0% to 200% of the target award depending on goal achievement over the performance period.
As of the grant date using the intrinsic value method using the closing price of our common stock
Amortized on a straight-line basis over the vesting term into Cost of sales, Selling, informational and administrative expenses, and/or Research and development expenses, as appropriate, and adjusted each reporting period, as necessary, to reflect changes in the price of our common stock, the number of shares that are probable of being earned and management’s assessment of the probability that the specified performance criteria will be achieved.
Breakthrough Performance Awards (BPAs)
Select employees identified as instrumental in delivering medicines to patients (excluding executive officers)
•Entitle the holder to receive, at the end of the performance period, shares of our common stock, if any, including shares resulting from dividend equivalents earned on such shares.
•For BPAs granted, the awards, if earned/vested, are settled at the end of the performance period, but no earlier than the one-year anniversary of the date of grant and dependent upon the achievement of the respective predetermined performance goals related to advancing Pfizer’s product pipeline during the performance period.
•The number of shares that may be earned ranges from 0% to 600% of the target award depending on the level and timing of goal achievement over the performance period.
As of the grant date using the intrinsic value method using the closing price of our common stock
Amortized on a straight-line basis over the probable vesting term into Cost of sales, Selling, informational and administrative expenses, and/or Research and development expenses, as appropriate, and adjusted each reporting period, as necessary, to reflect changes in the price of our common stock, the number of shares that are probable of being earned and management’s assessment of the probability that the specified performance criteria will be achieved and/or management’s assessment of the probable vesting term.
Awarded toTermsValuationRecognition and Presentation
Stock Options
Select employees
•Entitle the holder to purchase a specified number of shares of our common stock at a price per share equal to the closing market price of our common stock on the date of grant, for a period of time when vested.
•Since 2016, only a limited set of non-U.S. employees received stock option grants. No stock options were awarded to senior and other key management in any period presented.
•Stock options vest on the third anniversary of the grant assuming continuous service from the grant date and have a contractual term of 10 years.
As of the grant date using the Black-Scholes-Merton option-pricing model
Amortized on a straight-line basis over the vesting term into Cost of sales, Selling, informational and administrative expenses, and/or Research and development expenses, as appropriate.
(a)Retirement-eligible holders, as defined in the grant terms, can convert their TSRUs, when vested, into Profit Units (PTUs) with a conversion ratio based on a calculation used to determine the shares at TSRU settlement. The PTUs are entitled to earn Dividend Equivalent Units (DEUs), and the PTUs and DEUs will be settled in our common stock on the TSRUs’ original settlement date and will be subject to the terms and conditions of the original grant including forfeiture provisions.
(b)In 2017, Performance Total Shareholder Return Units (PTSRUs) were awarded to the Former Chairman and Chief Executive Officer (1,444,395 PTSRUs) and 361,099 PTSRUs were awarded to the Group President, Chief Business Officer (former role Group President Pfizer Innovative Health) at a grant price of $30.31 and at a GDFV of $5.54 per PTSRU. In addition to having the same characteristics and valuation methodology of TSRUs, PTSRU grants require special service and performance conditions.
Schedule of Share-based Payment Arrangement Activity
The following provides data related to all TSRU, RSU, PPS, PSA and stock option activity:
(MILLIONS, EXCEPT FAIR VALUE OF SHARES VESTED PER TSRU AND STOCK OPTION)TSRUsRSUsPPSsPSAsStock Options
Year Ended December 31,202120202019202120202019202120202019202120202019202120202019
Total fair value of shares vested(a)
$7.26$6.22$8.52$304$334$454$181$119$136$33$25$64$4.86$3.56$5.98
Total intrinsic value of options exercised or share units converted$594$84$175$228$224$245$584$293$261
Cash received upon exercise$795$425$394
Tax benefits realized from exercise$106$55$47
Compensation cost recognized, pre-tax(b)
$259$287$294$281$272$275$535$180$114$76$31$28$5$6$7
Total compensation cost related to nonvested awards not yet recognized, pre-tax$187$224$229$271$228$241$175$104$87$54$32$34$3$4$5
Weighted-average period over which cost is expected to be recognized (years)1.61.61.61.81.71.71.81.81.81.81.91.81.61.71.6
(a)Weighted-average GDFV per TSRUs and stock options.
(b)TSRU includes expense for PTSRUs, which is not significant for all years presented.
Summary of all TSRU, RSU, PPS, PSA and BPA activity during 2021 (with the shares granted representing the maximum award that could be achieved for PPSs, PSAs and BPAs):
TSRUsRSUs
PPSs(a)
PSAsBPAs
TSRUs Per TSRU, Weighted AverageShares  Weighted Avg. GDFV per shareShares Weighted Avg. Intrinsic Value per shareShares Weighted Avg. Intrinsic Value per shareShares Weighted Avg. Intrinsic Value per share
(Thousands)GDFVGrant Price(Thousands)(Thousands)(Thousands)(Thousands)
Nonvested,
December 31, 2020
129,844$6.90 $32.94 23,692$35.50 20,077$36.81 5,264$36.81 — $— 
Granted34,5227.26 33.83 10,89334.31 8,63233.82 1,79833.82 1,16538.73 
Vested(44,888)7.21 30.54 (8,747)34.66 (6,095)33.88 (984)33.85 — — 
Reinvested dividend equivalents956 41.33 
Forfeited(4,879)6.77 33.78 (1,255)35.17 (1,133)41.45 (924)34.43 (306)47.47 
Nonvested, December 31, 2021
114,599$6.90 $34.12 25,540$35.52 21,480$59.05 5,154$59.05 859$59.05 
(a)Vested and non-vested shares outstanding, but not paid as of December 31, 2021 were 34.1 million.
Summary of TSRU and PTU information as of December 31, 2021(a), (b):
TSRUs
(Thousands)
PTUs
(Thousands)
Weighted-Average
Grant Price
Per TSRU
Weighted-Average
Remaining Contractual Term (Years)
Aggregate Intrinsic Value (Millions)
TSRUs Outstanding206,996 — $31.71 2.2$5,969 
TSRUs Vested92,398 — 28.72 0.82,946 
TSRUs Expected to vest(c)
110,476 — 34.16 3.32,910 
TSRUs exercised and converted to PTUs— 3,074 $— 0.8$182 
(a)In 2021, we settled 46,060,346 TSRUs with a weighted-average grant price of $23.04 per unit.
(b)In 2021, 7,093,787 TSRUs with a weighted-average grant price of $27.41 per unit were converted into 2,943,737 PTUs.
(c)The number of TSRUs expected to vest takes into account an estimate of expected forfeitures.
Schedule of Valuation Assumptions
Summary of the weighted-average assumptions used in the valuation of TSRUs and stock options:
TSRUsStock Options
Year Ended December 31,202120202019202120202019
Expected dividend yield (based on a constant dividend yield during the expected term)
4.51 %4.36 %3.27 %4.51 %4.36 %3.27 %
Risk-free interest rate (based on interpolated yield on U.S. Treasury zero-coupon issues)
0.93 %1.15 %2.55 %1.27 %1.25 %2.66 %
Expected stock price volatility (based on implied volatility, after consideration of historical volatility)
26.53 %20.99 %18.34 %26.54 %20.97 %18.34 %
TSRUs contractual/stock options expected term, years (based on historical exercise and post-vesting termination patterns for stock options)
5.155.125.136.756.756.75
Schedule of Share-based Compensation, Stock Options, Activity
Summary of all stock option activity during 2021:
Shares
(Thousands)
Weighted-Average
Exercise Price
Per Share
Weighted-Average
Remaining Contractual Term
(Years)
Aggregate
Intrinsic Value(a)
(Millions)
Outstanding, December 31, 2020
75,402 $28.31 
Granted779 33.82 
Exercised(31,036)25.75 
Forfeited(89)34.39 
Expired(181)20.27   
Outstanding, December 31, 2021
44,874 30.20 2.7$1,295 
Vested and expected to vest, December 31, 2021(b)
44,747 30.19 2.71,291 
Exercisable, December 31, 2021
41,583 $29.81 2.3$1,216 
(a)Market price of our underlying common stock less exercise price.
(b)The number of options expected to vest takes into account an estimate of expected forfeitures.
v3.22.0.1
Earnings Per Common Share Attributable to Pfizer Inc. Common Shareholders (Tables)
 12 Months Ended
Dec. 31, 2021
Earnings Per Share [Abstract]  
Schedule of Basic and Diluted Earning Per Share
The following presents the detailed calculation of EPS:
 Year Ended December 31,
(IN MILLIONS)202120202019
EPS Numerator––Basic  
Income from continuing operations attributable to Pfizer Inc.
$22,414 $6,630 $10,708 
Less: Preferred stock dividends––net of tax— — 1 
Income from continuing operations attributable to Pfizer Inc. common shareholders
22,414 6,630 10,708 
Discontinued operations––net of tax(434)2,529 5,318 
Net income attributable to Pfizer Inc. common shareholders
$21,979 $9,159 $16,025 
EPS Numerator––Diluted  
Income from continuing operations attributable to Pfizer Inc. common shareholders and assumed conversions
$22,414 $6,630 $10,708 
Discontinued operations––net of tax, attributable to Pfizer Inc. common shareholders and assumed conversions(434)2,529 5,318 
Net income attributable to Pfizer Inc. common shareholders and assumed conversions
$21,979 $9,159 $16,026 
EPS Denominator  
Weighted-average number of common shares outstanding––Basic5,601 5,555 5,569 
Common-share equivalents: stock options, stock issuable under employee compensation plans convertible preferred stock and accelerated share repurchase agreements107 77 106 
Weighted-average number of common shares outstanding––Diluted
5,708 5,632 5,675 
Anti-dilutive common stock equivalents(a)
2 4 2 
(a)These common stock equivalents were outstanding for the periods presented, but were not included in the computation of diluted EPS for those periods because their inclusion would have had an anti-dilutive effect.
v3.22.0.1
Leases (Tables)
 12 Months Ended
Dec. 31, 2021
Leases [Abstract]  
Schedule of Lease Assets and Liabilities
For operating leases, the ROU assets and liabilities in our consolidated balance sheets follows:
As of December 31,
(MILLIONS)Balance Sheet Classification20212020
ROU assetsOther noncurrent assets$2,839 $1,386 
Lease liabilities (short-term)Other current liabilities449 320 
Lease liabilities (long-term)Other noncurrent liabilities2,510 1,108 
Schedule of Lease Costs and Other Supplemental Information
Components of total lease cost includes:
Year Ended December 31,
(MILLIONS)202120202019
Operating lease cost$548 $432 $421 
Variable lease cost381 380 326 
Sublease income(41)(40)(45)
Total lease cost$888 $772 $702 
Other supplemental information follows:
As of December 31,
(MILLIONS)20212020
Operating leases
Weighted-Average Remaining Contractual Lease Term (Years)126.9
Weighted-Average Discount Rate2.8 %2.9 %
Year Ended December 31,
(MILLIONS)202120202019
Cash paid for amounts included in the measurement of lease liabilities:
Operating cash flows from operating leases$387 $333 $338 
(Gains)/losses on sale and leaseback transactions, net1 (3)(29)
Schedule of Future Minimum Rental Payments for Operating Leases
The following reconciles the undiscounted cash flows for the first five years and total of the remaining years to the operating lease liabilities recorded in the consolidated balance sheet as of December 31, 2021:
(MILLIONS)
PeriodOperating Lease Liabilities
Next one year(a)
$520 
1-2 years417 
2-3 years322 
3-4 years279 
4-5 years217 
Thereafter1,865 
Total undiscounted lease payments3,621 
Less: Imputed interest
661 
Present value of minimum lease payments2,960 
Less: Current portion
449 
Noncurrent portion$2,510 
(a)Reflects lease payments due within 12 months subsequent to the balance sheet date.
v3.22.0.1
Segment, Geographic and Other Revenue Information (Tables)
 12 Months Ended
Dec. 31, 2021
Segment Reporting [Abstract]  
Schedule of Segment Reporting Information by Segment
The following table provides selected income statement information by reportable segment:
 Revenues
Earnings(a)
Depreciation and Amortization(b)
Year Ended December 31,Year Ended December 31,Year Ended December 31,
(MILLIONS OF DOLLARS)20212020 2019 20212020 201920212020 2019
Reportable Segment:
Biopharma$79,557 $40,724 $38,013 $40,226 $27,089 $24,419 $1,439 $1,013 $978 
Other business activities(c)
1,731 926 2,892 (10,396)(12,308)(11,216)598 603 592 
Reconciling Items:
Purchase accounting adjustments— — — (3,175)(3,117)(4,153)3,067 3,047 4,145 
Acquisition-related costs— — — (52)(44)(185)— — 3 
Certain significant items(d)
— — — (2,292)(4,584)2,456 87 18 37 
$81,288 $41,651 $40,905 $24,311 $7,036 $11,321 $5,191 $4,681 $5,755 
(a)Income from continuing operations before provision/(benefit) for taxes on income. Biopharma’s earnings include dividend income from our investment in ViiV of $166 million in 2021, $278 million in 2020 and $220 million in 2019.
(b)Certain production facilities are shared. Depreciation is allocated based on estimates of physical production. Amounts here relate solely to the depreciation and amortization associated with continuing operations.
(c)Other business activities include revenues and costs associated with PC1, as well as costs associated with global WRDM and GPD platform functions, global corporate enabling functions and other corporate items, as noted above, that we do not allocate to our operating segments. In 2019, Other business activities also include revenues and costs associated with our former Consumer Healthcare business through July 31, 2019. See Note 2C.
(d)Certain significant items are substantive and/or unusual, and in some cases recurring, items (as noted above) that, either as a result of their nature or size, would not be expected to occur as part of our normal business on a regular basis. For Earnings in 2021, includes, among other items: (i) a $2.1 billion charge for IPR&D related to our acquisition of Trillium, which was accounted for as an asset acquisition and recorded in Research and development expenses, (ii) restructuring charges/(credits) and implementation costs and additional depreciation—asset restructuring of $1.3 billion ($450 million recorded in Selling, informational and administrative expenses and the remaining amount primarily recorded in Restructuring charges and certain acquisition-related costs) and (iii) upfront and milestone payments on collaborative and licensing arrangements of $1.1 billion recorded in Research and development expenses, partially offset by (iv) actuarial valuation and other pension and postretirement plan gains of $1.6 billion recorded in Other (income)/deductions––net and (v) gains on equity securities of $1.3 billion recorded in Other (income)/deductions––net. For Earnings in 2020, includes, among other items; (i) charges of $1.7 billion related to certain asset impairments recorded in Other (income)/deductions––net, (ii) actuarial valuation and other pension and postretirement plan losses of $1.1 billion recorded in Other (income)/deductions––net and (iii) restructuring charges/(credits) and implementation costs and additional depreciation—asset restructuring of $791 million ($197 million recorded in Selling, informational and administrative expenses and the remaining amount primarily recorded in Restructuring charges and certain acquisition-related costs). For Earnings in 2019, includes, among other items: (i) a pre-tax gain of $8.1 billion recorded in (Gain) on completion of Consumer Healthcare JV transaction associated with the completion of the Consumer Healthcare JV transaction, partially offset by (ii) charges of $2.8 billion related to certain asset impairments recorded in Other (income)/deductions––net and (iii) actuarial valuation and other pension and postretirement plan losses of $750 million recorded in Other (income)/deductions––net. For additional information, see Notes 2A, 2C, 3 and 4.
Revenue from External Customers by Geographic Areas
The following summarizes revenues by geographic area:
 Year Ended December 31,
(MILLIONS)202120202019
United States$29,746 $21,455 $20,326 
Developed Europe18,336 7,788 7,729 
Developed Rest of World12,506 4,036 4,022 
Emerging Markets20,701 8,372 8,828 
Revenues
$81,288 $41,651 $40,905 
Schedules of Concentration of Risk
The following summarizes revenue, as a percentage of total revenues, for our three largest U.S. wholesaler customers:
 Year Ended December 31,
202120202019
McKesson, Inc.
9 %16 %15 %
AmerisourceBergen Corporation
7 %14 %11 %
Cardinal Health, Inc.5 %10 %9 %
Schedule of Significant Product Revenues
The following provides detailed revenue information for several of our major products:
(MILLIONS)Year Ended December 31,
PRODUCTPRIMARY INDICATION OR CLASS202120202019
TOTAL REVENUES(a)
$81,288 $41,651 $40,905 
PFIZER BIOPHARMACEUTICALS GROUP (BIOPHARMA)(a), (b)
$79,557 $40,724 $38,013 
Vaccines$42,625 $6,575 $6,504 
Comirnaty direct sales and alliance revenues
Active immunization to prevent COVID-19
36,781 154 — 
Prevnar family(c)
Pneumococcal disease5,272 5,850 5,847 
Nimenrix
Meningococcal ACWY disease193 221 230 
FSME-IMMUN/TicoVac
Tick-borne encephalitis disease
185 196 220 
TrumenbaMeningococcal B disease118 112 135 
All other Vaccines
Various74 42 73 
Oncology$12,333 $10,867 $9,014 
IbranceHR-positive/HER2-negative metastatic breast cancer5,437 5,392 4,961 
Xtandi alliance revenuesmCRPC, nmCRPC, mCSPC1,185 1,024 838 
Inlyta
Advanced RCC1,002 787 477 
Sutent
Advanced and/or metastatic RCC, adjuvant RCC, refractory GIST (after disease progression on, or intolerance to, imatinib mesylate) and advanced pancreatic neuroendocrine tumor
673 819 936 
Bosulif
Philadelphia chromosome–positive chronic myelogenous leukemia540 450 365 
Xalkori
ALK-positive and ROS1-positive advanced NSCLC493 544 530 
Ruxience(d)
Non-hodgkin’s lymphoma, chronic lymphocytic leukemia, granulomatosis with polyangiitis (Wegener’s Granulomatosis) and microscopic polyangiitis491 170 (1)
Retacrit(d)
Anemia444 386 225 
Zirabev(d)
Treatment of mCRC; unresectable, locally advanced, recurrent or metastatic NSCLC; recurrent glioblastoma; metastatic RCC; and persistent, recurrent or metastatic cervical cancer444 143 1 
Lorbrena
ALK-positive metastatic NSCLC
266 204 115 
AromasinPost-menopausal early and advanced breast cancer211 148 136 
Trazimera(d)
HER-positive breast cancer and metastatic stomach cancers
197 98 6 
BesponsaRelapsed or refractory B-cell acute lymphoblastic leukemia 192 182 157 
Braftovi
In combination with Mektovi for metastatic melanoma in patients with a BRAFV600E/K mutation and, in combination with Erbitux® (cetuximab), for the treatment of BRAFV600E-mutant mCRC after prior therapy
187 160 48 
Bavencio alliance revenuesLocally advanced or metastatic urothelial carcinoma; metastatic Merkel cell carcinoma; immunotherapy and tyrosine kinase inhibitor combination for patients with advanced RCC178 80 49 
Mektovi
In combination with Braftovi for metastatic melanoma in patients with a BRAFV600E/K mutation
155 142 49 
All other Oncology
Various238 137 122 
Internal Medicine$9,329 $9,003 $8,790 
Eliquis alliance revenues and direct sales
Nonvalvular atrial fibrillation, deep vein thrombosis, pulmonary embolism5,970 4,949 4,220 
Premarin family
Symptoms of menopause563 680 734 
Chantix/Champix
An aid to smoking cessation treatment in adults 18 years of age or older
398 919 1,107 
BMP2
Development of bone and cartilage266 274 287 
Toviaz
Overactive bladder238 252 250 
PristiqDepression187 171 176 
All other Internal Medicine
Various1,706 1,758 2,016 
(MILLIONS)Year Ended December 31,
PRODUCTPRIMARY INDICATION OR CLASS202120202019
Hospital(a)
$7,301 $6,777 $6,695 
Sulperazon
Bacterial infections683 618 684 
MedrolAnti-inflammatory glucocorticoid432 402 469 
ZaviceftaBacterial infections413 212 108 
Fragmin
Treatment/prevention of venous thromboembolism305 252 253 
ZithromaxBacterial infections278 276 336 
Vfend
Fungal infections267 270 346 
TygacilBacterial infections200 160 197 
PrecedexSedation agent in surgery or intensive care177 260 155 
Zyvox
Bacterial infections173 222 251 
Paxlovid
COVID-19 Infection (high risk population)
76 — — 
IVIg Products(e)
Various430 376 275 
All other Anti-infectives
Various1,453 1,294 1,396 
All other HospitalVarious2,412 2,435 2,225 
Inflammation & Immunology (I&I)$4,431 $4,567 $4,733 
Xeljanz
RA, PsA, UC, active polyarticular course juvenile idiopathic arthritis, ankylosing spondylitis2,455 2,437 2,242 
Enbrel (Outside the U.S. and Canada)
RA, juvenile idiopathic arthritis, PsA, plaque psoriasis, pediatric plaque psoriasis, ankylosing spondylitis and nonradiographic axial spondyloarthritis
1,185 1,350 1,699 
Inflectra/Remsima(d)
Crohn’s disease, pediatric Crohn’s disease, UC, pediatric UC, RA in combination with methotrexate, ankylosing spondylitis, PsA and plaque psoriasis
657 659 625 
All other I&I
Various134 121 167 
Rare Disease
$3,538 $2,936 $2,278 
Vyndaqel/VyndamaxATTR-cardiomyopathy and polyneuropathy2,015 1,288 473 
BeneFIXHemophilia B438 454 488 
Genotropin
Replacement of human growth hormone389 427 498 
Refacto AF/Xyntha
Hemophilia A304 370 426 
Somavert
Acromegaly277 277 264 
All other Rare Disease
Various115 120 129 
PFIZER CENTREONE(b)
$1,731 $926 $810 
CONSUMER HEALTHCARE BUSINESS(f)
$— $— $2,082 
Total Alliance revenues$7,652 $5,418 $4,648 
Total Biosimilars(d)
$2,343 $1,527 $911 
Total Sterile Injectable Pharmaceuticals(g)
$5,746 $5,315 $5,013 
(a)On December 31, 2021, we completed the sale of our Meridian subsidiary. Prior to its sale, Meridian was managed as part of the Hospital therapeutic area. On November 16, 2020, we completed the spin-off and the combination of our Upjohn Business with Mylan to form Viatris. On December 21, 2020, Pfizer and Viatris completed the termination of the Mylan-Japan collaboration. Beginning in the fourth quarter of 2021, the financial results of Meridian are reflected as discontinued operations for all periods presented. Beginning in the fourth quarter of 2020, the financial results of the Upjohn Business and Mylan-Japan collaboration were reflected as discontinued operations for all periods presented. Prior-period financial information has been restated, as appropriate. See Note 1A.
(b)At the beginning of our fiscal fourth quarter of 2021, we reorganized our commercial operations and began to manage our commercial operations through a new global structure consisting of two operating segments, each led by a single manager: Biopharma, our innovative science-based biopharmaceutical business and PC1. PC1, which previously had been managed within the Hospital therapeutic area, includes revenues from our contract manufacturing, including certain Comirnaty-related manufacturing activities performed on behalf of BioNTech ($320 million for 2021 and $0 million for 2020 and 2019), and active pharmaceutical ingredient sales operation, as well as revenues related to our manufacturing and supply agreements with former legacy Pfizer businesses/partnerships, including but not limited to, transitional manufacturing and supply agreements with Viatris following the spin-off of the Upjohn Business. We have revised prior period information to conform to the current management structure.
(c)Prevnar family include revenues from Prevnar 13/Prevenar 13 (pediatric and adult) and Prevnar 20 (adult).
(d)Biosimilars are highly similar versions of approved and authorized biological medicines and primarily include revenues from Inflectra/Remsima, Ruxience, Retacrit, Zirabev and Trazimera.
(e)Intravenous immunoglobulin (IVIg) products include the revenues from Panzyga, Octagam and Cutaquig.
(f)On July 31, 2019, our Consumer Healthcare business, an OTC medicines business, was combined with GSK’s consumer healthcare business to form a new consumer healthcare JV. See Note 2C.
(g)Total Sterile Injectable Pharmaceuticals represents the total of all branded and generic injectable products in the Hospital therapeutic area, including anti-infective sterile injectable pharmaceuticals.
v3.22.0.1
Basis of Presentation and Significant Accounting Policies - Narrative (Details)
$ in Millions
 12 Months Ended
Dec. 31, 2021
USD ($)
operatingSegment
Dec. 31, 2020
USD ($)
Dec. 31, 2019
USD ($)
Jan. 01, 2020
USD ($)
New Accounting Pronouncements or Change in Accounting Principle [Line Items]        
Number of operating segments | operatingSegment 2      
Decrease to retained earnings $ (103,394) $ (90,392)    
Increase to AOCI (5,897) (5,310)    
Advertising expense 2,000 1,800 $ 2,300  
Change in Accounting Principle, Adjustment [Member]        
New Accounting Pronouncements or Change in Accounting Principle [Line Items]        
Decrease to retained earnings       $ 6,000
Increase to AOCI       $ 6,000
Revenue [Member] | Top Nine Products [Member] | Product Concentration Risk [Member]        
New Accounting Pronouncements or Change in Accounting Principle [Line Items]        
Concentration risk, amount $ 1,000      
Concentration risk, percentage 75.00%      
Revenue [Member] | Top Seven Products [Member] | Product Concentration Risk [Member]        
New Accounting Pronouncements or Change in Accounting Principle [Line Items]        
Concentration risk, amount   $ 1,000    
Concentration risk, percentage   54.00%    
Revenue [Member] | Top Six Products [Member] | Product Concentration Risk [Member]        
New Accounting Pronouncements or Change in Accounting Principle [Line Items]        
Concentration risk, amount     $ 1,000  
Concentration risk, percentage     49.00%  
v3.22.0.1
Basis of Presentation and Significant Accounting Policies - Summary of Change in Accounting Principle (Details) - USD ($)
$ / shares in Units, $ in Millions
 12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Consolidated Statements of Income:      
(Gain) on completion of Consumer Healthcare JV transaction $ 0 $ (6) $ (8,107)
Other (income)/deductions––net (4,878) 1,219 3,497
Income from continuing operations before provision/(benefit) for taxes on income [1],[2],[3] 24,311 7,036 11,321
Provision/(benefit) for taxes on income 1,852 370 583
Discontinued operations––net of tax (434) 2,529 5,318
Net income before allocation to noncontrolling interests 22,025 9,195 16,056
Net income attributable to Pfizer Inc. common shareholders $ 21,979 $ 9,159 $ 16,026
Earnings per common share––basic:      
Income from continuing operations attributable to Pfizer Inc. common shareholders (in dollars per share) $ 4.00 $ 1.19 $ 1.92
Discontinued operations––net of tax (in dollars per share) (0.08) 0.46 0.95
Net income attributable to Pfizer Inc. common shareholders (in dollars per share) 3.92 1.65 2.88
Earnings per common share––diluted:      
Income from continuing operations attributable to Pfizer Inc. common shareholders (in dollars per share) 3.93 1.18 1.89
Discontinued operations––net of tax (in dollars per share) (0.08) 0.45 0.94
Net income attributable to Pfizer Inc. common shareholders (in dollars per share) $ 3.85 $ 1.63 $ 2.82
Consolidated Statements of Comprehensive Income:      
Foreign currency translation adjustments, net $ (682) $ 772 $ 675
Benefit plans: actuarial gains/(losses), net 0 0 0
Reclassification adjustments related to amortization 0 0 0
Reclassification adjustments related to settlements, net 0 0 0
Other 0 0 0
Tax provision/(benefit) on other comprehensive income/(loss) 71 (227) 178
Consolidated Statements of Cash Flows:      
Deferred taxes from continuing operations (4,293) (1,575) 561
Benefit plan contributions in excess of expense/income (3,123) (1,242) (55)
Consolidated Balance Sheets:      
Noncurrent deferred tax assets and other noncurrent tax assets 3,341 2,383  
Other noncurrent assets 7,679 4,879  
Pension benefit obligations 3,489 4,766  
Retained earnings 103,394 90,392  
Accumulated other comprehensive loss (5,897) (5,310)  
Previous Accounting Principle [Member]      
Consolidated Statements of Income:      
(Gain) on completion of Consumer Healthcare JV transaction 0 (6) (8,086)
Other (income)/deductions––net (2,820) 672 3,264
Income from continuing operations before provision/(benefit) for taxes on income 22,253 7,584 11,533
Provision/(benefit) for taxes on income 1,399 496 631
Discontinued operations––net of tax (434) 2,564 5,400
Net income before allocation to noncontrolling interests 20,420 9,652 16,302
Net income attributable to Pfizer Inc. common shareholders $ 20,374 $ 9,616 $ 16,273
Earnings per common share––basic:      
Income from continuing operations attributable to Pfizer Inc. common shareholders (in dollars per share) $ 3.71 $ 1.27 $ 1.95
Discontinued operations––net of tax (in dollars per share) (0.08) 0.46 0.97
Net income attributable to Pfizer Inc. common shareholders (in dollars per share) 3.63 1.73 2.92
Earnings per common share––diluted:      
Income from continuing operations attributable to Pfizer Inc. common shareholders (in dollars per share) 3.65 1.25 1.92
Discontinued operations––net of tax (in dollars per share) (0.08) 0.46 0.95
Net income attributable to Pfizer Inc. common shareholders (in dollars per share) $ 3.57 $ 1.71 $ 2.87
Consolidated Statements of Comprehensive Income:      
Foreign currency translation adjustments, net $ (731) $ 957 $ 654
Benefit plans: actuarial gains/(losses), net 1,565 (1,128) (826)
Reclassification adjustments related to amortization 285 276 241
Reclassification adjustments related to settlements, net 209 278 274
Other 49 (189) 22
Tax provision/(benefit) on other comprehensive income/(loss) 545 (349) 115
Consolidated Statements of Cash Flows:      
Deferred taxes from continuing operations (4,746) (1,449) 609
Benefit plan contributions in excess of expense/income (1,065) (1,790) (288)
Consolidated Balance Sheets:      
Noncurrent deferred tax assets and other noncurrent tax assets 3,320   2,383
Other noncurrent assets 7,679   4,879
Pension benefit obligations 3,489   4,766
Retained earnings 101,789   96,770
Accumulated other comprehensive loss (4,313)   (11,688)
Impact of Change [Member]      
Consolidated Statements of Income:      
(Gain) on completion of Consumer Healthcare JV transaction 0 0 (21)
Other (income)/deductions––net (2,058) 547 233
Income from continuing operations before provision/(benefit) for taxes on income 2,058 (547) (212)
Provision/(benefit) for taxes on income 453 (125) (48)
Discontinued operations––net of tax 0 (35) (82)
Net income before allocation to noncontrolling interests 1,605 (457) (246)
Net income attributable to Pfizer Inc. common shareholders $ 1,605 $ (457) $ (246)
Earnings per common share––basic:      
Income from continuing operations attributable to Pfizer Inc. common shareholders (in dollars per share) $ 0.29 $ (0.08) $ (0.03)
Discontinued operations––net of tax (in dollars per share) 0 (0.01) (0.01)
Net income attributable to Pfizer Inc. common shareholders (in dollars per share) 0.29 (0.08) (0.04)
Earnings per common share––diluted:      
Income from continuing operations attributable to Pfizer Inc. common shareholders (in dollars per share) 0.28 (0.07) (0.03)
Discontinued operations––net of tax (in dollars per share) 0 (0.01) (0.01)
Net income attributable to Pfizer Inc. common shareholders (in dollars per share) $ 0.28 $ (0.08) $ (0.04)
Consolidated Statements of Comprehensive Income:      
Foreign currency translation adjustments, net $ 49 $ (185) $ 21
Benefit plans: actuarial gains/(losses), net (1,565) 1,128 826
Reclassification adjustments related to amortization (285) (276) (241)
Reclassification adjustments related to settlements, net (209) (278) (274)
Other (49) 189 (22)
Tax provision/(benefit) on other comprehensive income/(loss) (475) 122 63
Consolidated Statements of Cash Flows:      
Deferred taxes from continuing operations 453 (125) (48)
Benefit plan contributions in excess of expense/income (2,058) $ 547 233
Consolidated Balance Sheets:      
Noncurrent deferred tax assets and other noncurrent tax assets 22   0
Other noncurrent assets 0   0
Pension benefit obligations 0   0
Retained earnings 1,605   (6,378)
Accumulated other comprehensive loss $ (1,583)   $ 6,378
[1] Income from continuing operations before provision/(benefit) for taxes on income. Biopharma’s earnings include dividend income from our investment in ViiV of $166 million in 2021, $278 million in 2020 and $220 million in 2019.
[2] 2020 v. 2019––The domestic loss in 2020 versus domestic income in 2019 was mainly related to the non-recurrence of the gain on the completion of the Consumer Healthcare JV transaction as well as higher asset impairment charges and higher R&D expenses. The increase in the international income was primarily related to the non-recurrence of the write off of assets contributed to the Consumer Healthcare JV as well as lower asset impairment charges and lower amortization of intangible assets.
[3] 2021 v. 2020––The domestic income in 2021 versus domestic loss in 2020 was mainly related to Comirnaty income, lower asset impairment charges, net periodic benefit credits in 2021 versus net periodic benefit costs in 2020 and higher net gains from equity securities, partially offset by higher R&D expenses. The increase in the international income was primarily related to Comirnaty income, net periodic benefit credits in 2021 versus net periodic benefit costs in 2020 and lower asset impairment charges.
v3.22.0.1
Basis of Presentation and Significant Accounting Policies - Accrued Rebates and Other Accruals (Details) - USD ($)
$ in Millions
Dec. 31, 2021
Dec. 31, 2020
Schedule Of Accrued Liabilities [Line Items]    
Total accrued rebates and other sales-related accruals $ 5,850 $ 4,708
Trade accounts receivable, less allowance for doubtful accounts [Member]    
Schedule Of Accrued Liabilities [Line Items]    
Total accrued rebates and other sales-related accruals 1,077 861
Other current liabilities [Member]    
Schedule Of Accrued Liabilities [Line Items]    
Accrued rebates 3,811 3,017
Other accruals 528 432
Other noncurrent liabilities [Member]    
Schedule Of Accrued Liabilities [Line Items]    
Total accrued rebates and other sales-related accruals $ 433 $ 399
v3.22.0.1
Acquisitions, Divestitures, Equity-Method Investments, Licensing Arrangements and Collaborative Arrangements - Acquisitions (Details) - USD ($)
$ / shares in Units, $ in Millions
 11 Months Ended 12 Months Ended
Nov. 17, 2021
Jul. 30, 2019
Jul. 01, 2019
Nov. 16, 2021
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Business Acquisition [Line Items]              
Cash payments for acquisition, net of cash acquired         $ 0 $ 0 $ 10,861
Finite-lived intangible asset, useful life         8 years    
Goodwill [1]         $ 49,208 49,556 48,181
Trillium [Member]              
Business Acquisition [Line Items]              
Ownership percentage       2.00%      
Trillium [Member]              
Business Acquisition [Line Items]              
Asset acquisition, share price (in dollars per share) $ 18.50            
Asset acquisition, consideration transferred $ 2,000            
Charge to research and development expenses in connection with asset acquisition 2,100       $ 2,100    
Asset acquisition, assets acquired 256            
Asset acquisition, liabilities assumed $ 81            
Therachon Asset Acquisition [Member]              
Business Acquisition [Line Items]              
Asset acquisition, consideration transferred     $ 322        
Charge to research and development expenses in connection with asset acquisition     337        
Upfront payment     340        
Maximum potential milestone payments     470        
Payments to acquire asset     317        
Asset acquisition, consideration transferred, equity interest     $ 5        
Array [Member]              
Business Acquisition [Line Items]              
Business acquisition, per share in cash (in dollars per share)   $ 48          
Payments to acquire businesses, cash portion   $ 11,200          
Cash payments for acquisition, net of cash acquired   10,900          
Intangible assets   6,300          
Goodwill   6,100          
Net deferred tax liabilities   1,100          
Assumed long-term debt   451          
Array [Member] | Restructuring Charges And Acquisition-Related Costs [Member]              
Business Acquisition [Line Items]              
Post closing compensation expense             $ 157
Developed Technology Rights [Member]              
Business Acquisition [Line Items]              
Finite-lived intangible asset, useful life         7 years    
Developed Technology Rights [Member] | Array [Member]              
Business Acquisition [Line Items]              
Identifiable intangible assets   $ 2,000          
Acquired intangible assets, useful life   16 years          
IPR&D [Member] | Array [Member]              
Business Acquisition [Line Items]              
Identifiable intangible assets   $ 2,800          
Reduction in intangible assets due to measurement period adjustments           $ 900  
Licensing Agreements [Member] | Array [Member]              
Business Acquisition [Line Items]              
Intangible assets   1,500          
Licensing Agreements, Technology In Development [Member] | Array [Member]              
Business Acquisition [Line Items]              
Intangible assets   1,200          
Licensing Agreements, Developed Technology [Member] | Array [Member]              
Business Acquisition [Line Items]              
Identifiable intangible assets   $ 360          
Finite-lived intangible asset, useful life   10 years          
[1] As a result of the reorganization of our commercial operations during the fourth quarter of 2021 (see Note 17), we were required to estimate the relative fair values of our PC1 and Hospital organizations to determine any reallocation of goodwill. We completed this analysis and determined that no goodwill was required to be reallocated. As a result, our entire goodwill balance continues to be assigned within the Biopharma reportable segment.
v3.22.0.1
Acquisitions, Divestitures, Equity-Method Investments, Licensing Arrangements and Collaborative Arrangements - Divestitures (Details)
€ in Millions
 1 Months Ended 12 Months Ended
Dec. 31, 2021
USD ($)
Nov. 16, 2020
USD ($)
Nov. 13, 2020
USD ($)
Jun. 30, 2020
USD ($)
Dec. 31, 2021
USD ($)
Dec. 31, 2020
USD ($)
Dec. 31, 2019
USD ($)
Jun. 30, 2020
EUR (€)
May 31, 2020
USD ($)
Mar. 31, 2020
USD ($)
Mar. 31, 2019
USD ($)
Income Statement, Balance Sheet and Additional Disclosures by Disposal Groups, Including Discontinued Operations [Line Items]                      
Proceeds from issuance of long-term debt         $ 997,000,000 $ 5,222,000,000 $ 4,942,000,000        
Reduction in retained earnings $ (103,394,000,000)       (103,394,000,000) (90,392,000,000)          
Line of Credit [Member]                      
Income Statement, Balance Sheet and Additional Disclosures by Disposal Groups, Including Discontinued Operations [Line Items]                      
Line of credit facility, maximum borrowing capacity 360,000,000       360,000,000            
Line of Credit [Member] | Commercial Paper [Member]                      
Income Statement, Balance Sheet and Additional Disclosures by Disposal Groups, Including Discontinued Operations [Line Items]                      
Line of credit facility, maximum borrowing capacity       $ 4,000,000,000              
Senior Notes [Member]                      
Income Statement, Balance Sheet and Additional Disclosures by Disposal Groups, Including Discontinued Operations [Line Items]                      
Debt instrument, face amount                 $ 4,000,000,000 $ 1,250,000,000 $ 5,000,000,000
Unsecured Debt [Member] | Senior Notes Due 2021 [Member]                      
Income Statement, Balance Sheet and Additional Disclosures by Disposal Groups, Including Discontinued Operations [Line Items]                      
Repurchased debt       $ 1,150,000,000              
Stated interest rate       1.95%       1.95%      
Unsecured Debt [Member] | Senior Notes Due 2023 [Member]                      
Income Statement, Balance Sheet and Additional Disclosures by Disposal Groups, Including Discontinued Operations [Line Items]                      
Repurchased debt       $ 342,000,000              
Stated interest rate       5.80%       5.80%      
Discontinued Operations, Disposed of by Sale [Member] | Meridian [Member]                      
Income Statement, Balance Sheet and Additional Disclosures by Disposal Groups, Including Discontinued Operations [Line Items]                      
Cash received for disposition 51,000,000       $ 51,000,000            
Loss on sale of discontinued operations––net of tax 167,000,000                    
Discontinued Operations, Disposed of by Means Other than Sale, Spinoff [Member] | Upjohn Inc [Member]                      
Income Statement, Balance Sheet and Additional Disclosures by Disposal Groups, Including Discontinued Operations [Line Items]                      
Reduction in retained earnings   $ 1,600,000,000                  
Cash divested   412,000,000                  
Net increase to accumulated other comprehensive loss   423,000,000                  
Derecognition of net gains on foreign currency translation adjustment   397,000,000                  
Derecognition of prior service credits associated with benefit plans   $ 26,000,000                  
Separation-related costs           434,000,000 $ 83,000,000        
Purchaser of Meridian [Member] | Manufacturing and Supply Agreement [Member]                      
Income Statement, Balance Sheet and Additional Disclosures by Disposal Groups, Including Discontinued Operations [Line Items]                      
Period of continuing involvement after disposal         3 years            
Period of continuing involvement after disposal, extension period         2 years            
Purchaser of Meridian [Member] | Minimum [Member] | Transition Service Agreement [Member]                      
Income Statement, Balance Sheet and Additional Disclosures by Disposal Groups, Including Discontinued Operations [Line Items]                      
Period of continuing involvement after disposal         12 months            
Purchaser of Meridian [Member] | Maximum [Member] | Transition Service Agreement [Member]                      
Income Statement, Balance Sheet and Additional Disclosures by Disposal Groups, Including Discontinued Operations [Line Items]                      
Period of continuing involvement after disposal         18 months            
Viatris [Member]                      
Income Statement, Balance Sheet and Additional Disclosures by Disposal Groups, Including Discontinued Operations [Line Items]                      
Nontrade receivables $ 53,000,000       $ 53,000,000 $ 401,000,000          
Payment pursuant to terms of the separation agreement         $ 277,000,000            
Viatris [Member] | Minimum [Member] | Manufacturing and Supply Agreement [Member]                      
Income Statement, Balance Sheet and Additional Disclosures by Disposal Groups, Including Discontinued Operations [Line Items]                      
Period of continuing involvement after disposal         4 years            
Viatris [Member] | Maximum [Member] | Transition Service Agreement [Member]                      
Income Statement, Balance Sheet and Additional Disclosures by Disposal Groups, Including Discontinued Operations [Line Items]                      
Period of continuing involvement after disposal         3 years            
Viatris [Member] | Maximum [Member] | Manufacturing and Supply Agreement [Member]                      
Income Statement, Balance Sheet and Additional Disclosures by Disposal Groups, Including Discontinued Operations [Line Items]                      
Period of continuing involvement after disposal         7 years            
Viatris [Member] | Discontinued Operations, Disposed of by Means Other than Sale, Spinoff [Member] | Upjohn Inc [Member]                      
Income Statement, Balance Sheet and Additional Disclosures by Disposal Groups, Including Discontinued Operations [Line Items]                      
Cash received for disposition     $ 12,000,000,000                
Upjohn Inc and Upjohn Finance B.V. [Member]                      
Income Statement, Balance Sheet and Additional Disclosures by Disposal Groups, Including Discontinued Operations [Line Items]                      
Proceeds from issuance of long-term debt       $ 11,400,000,000              
Upjohn Inc and Upjohn Finance B.V. [Member] | Senior Notes [Member]                      
Income Statement, Balance Sheet and Additional Disclosures by Disposal Groups, Including Discontinued Operations [Line Items]                      
Debt instrument, face amount       600,000,000              
Upjohn Inc [Member]                      
Income Statement, Balance Sheet and Additional Disclosures by Disposal Groups, Including Discontinued Operations [Line Items]                      
Principal amount       $ 7,450,000,000              
Upjohn Finance B.V. [Member]                      
Income Statement, Balance Sheet and Additional Disclosures by Disposal Groups, Including Discontinued Operations [Line Items]                      
Principal amount | €               € 3,600      
Viatris [Member]                      
Income Statement, Balance Sheet and Additional Disclosures by Disposal Groups, Including Discontinued Operations [Line Items]                      
Ratio, shares received for each share held     0.124079                
Noncontrolling interest, ownership percentage by parent   57.00%                  
Viatris [Member] | Mylan [Member]                      
Income Statement, Balance Sheet and Additional Disclosures by Disposal Groups, Including Discontinued Operations [Line Items]                      
Ratio, shares received for each share held     1                
Noncontrolling interest, ownership percentage by noncontrolling owners   43.00%                  
v3.22.0.1
Acquisitions, Divestitures, Equity-Method Investments, Licensing Arrangements and Collaborative Arrangements - Summarized Financial Information of Discontinued Operations (Details) - USD ($)
$ in Millions
 1 Months Ended 12 Months Ended
Dec. 31, 2021
Jul. 31, 2021
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Costs and expenses:          
Discontinued operations––net of tax     $ (434) $ 2,529 $ 5,318
Certain legal matters, net [1]     182 28 292
Discontinued Operations [Member]          
Income Statement Disclosures          
Revenues [2]     277 7,572 10,845
Costs and expenses:          
Cost of sales [2]     204 2,106 2,173
Selling, informational and administrative expenses [2]     26 1,682 1,624
Research and development expenses [2]     9 224 265
Amortization of intangible assets [2]     45 224 181
Restructuring charges and certain acquisition-related costs [2]     2 29 146
Other (income)/deductions––net [2]     365 428 401
Pre-tax income/(loss) from discontinued operations [2]     (375) 2,879 6,056
Provision/(benefit) for taxes on income [2]     (107) 349 738
Income/(loss) from discontinued operations––net of tax [2]     (268) 2,529 5,318
Pre-tax loss on sale of discontinued operations [2]     (211) 0 0
Benefit for taxes on income [2]     (44) 0 0
Loss on sale of discontinued operations––net of tax [2]     (167) 0 0
Discontinued operations––net of tax [2]     (434) 2,529 $ 5,318
Assets          
Current assets of discontinued operations and other assets held for sale––Other current assets [3] $ 25   25 215  
Property, plant and equipment [3] 0   0 155  
Identifiable intangible assets [3] 0   0 134  
Other noncurrent assets [3] 0   0 29  
Noncurrent assets of discontinued operations––Other noncurrent assets [3] 0   0 319  
Liabilities          
Current liabilities of discontinued operations––Other current liabilities [3] 0   0 74  
Noncurrent liabilities of discontinued operations––Other noncurrent liabilities [3] 0   0 16  
Discontinued Operations [Member] | Upjohn Inc and Upjohn Finance B.V. [Member]          
Costs and expenses:          
Interest expense       116  
Discontinued Operations [Member] | Upjohn Finance B. V.          
Costs and expenses:          
Pre-tax charges related to remeasurement of Euro debt       $ 223  
Discontinued Operations, Disposed of by Sale [Member] | Meridian [Member]          
Costs and expenses:          
Loss on sale of discontinued operations––net of tax $ (167)        
Discontinued Operations, Disposed of by Sale [Member] | Meridian [Member] | Epi Pen [Member]          
Costs and expenses:          
Certain legal matters, net   $ 345 $ 345    
[1] Includes legal reserves for certain pending legal matters.
[2] In 2021, Discontinued operations—net of tax primarily includes (i) the operations of Meridian prior to its sale on December 31, 2021 recognized in Income/(loss) from discontinued operations—net of tax, which includes a pre-tax amount for a Multi-District Litigation relating to EpiPen against the Company in the U.S. District Court for the District of Kansas for $345 million; and (ii) the after tax loss of $167 million related to the sale of Meridian recognized in Loss on sale of discontinued operations––net of tax. To a much lesser extent, Discontinued operations—net of tax in 2021 also includes the operations of the Mylan-Japan collaboration prior to its termination on December 21, 2020 and post-closing adjustments directly related to our former Upjohn and Nutrition discontinued businesses, including adjustments for tax, benefits and legal-related matters recognized in Income/(loss) from discontinued operations—net of tax. In 2020 and 2019, Discontinued operations—net of tax relates to the operations of the Upjohn Business, Meridian and the Mylan-Japan collaboration and includes the change in accounting principle in the first quarter of 2021 to MTM Accounting. See Note 1C. In 2020, Discontinued operations—net of tax includes pre-tax interest expense of $116 million associated with the U.S. dollar and Euro denominated senior unsecured notes issued by Upjohn Inc. and Upjohn Finance B.V. in the second quarter of 2020 and pre-tax charges of $223 million related to the remeasurement of Euro debt issued by Upjohn Finance B.V. in the second quarter of 2020.
[3] Amounts as of December 31, 2021 represent property, plant and equipment held for sale. Amounts as of December 31, 2020 primarily relate to discontinued operations of our former Meridian subsidiary and the Mylan-Japan collaboration.
v3.22.0.1
Acquisitions, Divestitures, Equity-Method Investments, Licensing Arrangements and Collaborative Arrangements - Equity Method Investment (Details) - USD ($)
 3 Months Ended 7 Months Ended 12 Months Ended
Dec. 31, 2019
Sep. 29, 2019
Jul. 31, 2019
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Dec. 31, 2016
Schedule of Equity Method Investments [Line Items]              
Gain on completion of transaction       $ 0 $ 6,000,000 $ 8,107,000,000  
Equity-method investments       16,472,000,000 16,856,000,000    
Consumer Healthcare JV [Member]              
Schedule of Equity Method Investments [Line Items]              
Equity method investment, ownership percentage 32.00%   32.00%     32.00%  
Gain on completion of transaction   $ 8,100,000,000       $ 8,100,000,000  
Gain on completion of transaction, after-tax   $ 5,400,000,000          
Equity-method investments       16,300,000,000 16,700,000,000    
Dividend received       499,000,000      
Foreign currency translation adjustment       384,000,000      
Equity method investment earnings $ 47,000,000     $ 495,000,000 417,000,000    
Equity method investments 15,700,000,000   $ 15,700,000,000     15,700,000,000  
Underlying equity in net assets 11,000,000,000   11,200,000,000     11,000,000,000  
Difference between carrying amount and underlying equity $ 4,800,000,000   $ 4,500,000,000     4,800,000,000  
ViiV [Member]              
Schedule of Equity Method Investments [Line Items]              
Equity method investment, ownership percentage       11.70%      
Equity-method investments             $ 0
Dividend income       $ 166,000,000 $ 278,000,000 $ 220,000,000  
GSK [Member] | Consumer Healthcare JV [Member]              
Schedule of Equity Method Investments [Line Items]              
Equity method investment, ownership percentage     68.00%        
Consumer Healthcare JV [Member] | Held-for-sale, Not Discontinued Operations [Member]              
Schedule of Equity Method Investments [Line Items]              
Pre-tax income attributable to disposal group     $ 654,000,000        
Minimum [Member] | Consumer Healthcare JV [Member]              
Schedule of Equity Method Investments [Line Items]              
Excess basis amortization period       8 years      
Maximum [Member] | Consumer Healthcare JV [Member]              
Schedule of Equity Method Investments [Line Items]              
Excess basis amortization period       20 years      
v3.22.0.1
Acquisitions, Divestitures, Equity-Method Investments, Licensing Arrangements and Collaborative Arrangements - Summarized Financial Information of Equity Method Investee (Details) - USD ($)
$ in Millions
 2 Months Ended 12 Months Ended
Sep. 29, 2019
Dec. 31, 2021
Oct. 03, 2021
Dec. 31, 2020
Sep. 27, 2020
Dec. 31, 2019
Dec. 31, 2018
Equity Method Investment, Summarized Financial Information, Balance Sheet [Abstract]              
Current assets   $ 59,693   $ 35,067      
Total assets   181,476   154,229      
Current liabilities   42,671   25,920      
Total liabilities   104,013   90,756      
Total net equity/(deficit) attributable to shareholders   77,201   63,238      
Equity attributable to noncontrolling interests   262   235      
Total equity   77,462   63,473   $ 63,447 $ 63,758
Equity Method Investment, Summarized Financial Information [Abstract]              
Income from continuing operations   22,459   6,666   10,738  
Net income   22,025   9,195   16,056  
Income attributable to shareholders   21,979   9,159   16,026  
Consumer Healthcare JV [Member]              
Equity Method Investment, Summarized Financial Information, Balance Sheet [Abstract]              
Current assets     $ 6,890   $ 6,614    
Noncurrent assets     39,445   38,361    
Total assets     46,335   44,975    
Current liabilities     5,133   5,246    
Noncurrent liabilities     5,218   5,330    
Total liabilities     10,351   10,576    
Total net equity/(deficit) attributable to shareholders     35,705   34,154    
Equity attributable to noncontrolling interests     279   245    
Total equity     35,984   34,400    
Equity Method Investment, Summarized Financial Information [Abstract]              
Net sales $ 2,161   12,836   12,720    
Cost of sales (803)   (4,755)   (5,439)    
Gross profit 1,358   8,081   7,281    
Income from continuing operations 152   1,614   1,350    
Net income 152   1,614   1,350    
Income attributable to shareholders $ 148   $ 1,547   $ 1,307    
ViiV [Member] | ViiV [Member]              
Equity Method Investment, Summarized Financial Information, Balance Sheet [Abstract]              
Current assets   3,608   3,283      
Noncurrent assets   3,563   3,381      
Total assets   7,171   6,664      
Current liabilities   3,497   3,028      
Noncurrent liabilities   6,536   6,370      
Total liabilities   10,033   9,398      
Total net equity/(deficit) attributable to shareholders   (2,862)   (2,734)      
Equity Method Investment, Summarized Financial Information [Abstract]              
Net sales   6,380   6,224   6,139  
Cost of sales   (682)   (574)   (516)  
Gross profit   5,698   5,650   5,623  
Income from continuing operations   2,040   2,012   3,398  
Net income   2,040   2,012   3,398  
Income attributable to shareholders   $ 2,040   $ 2,012   $ 3,398  
v3.22.0.1
Acquisitions, Divestitures, Equity-Method Investments, Licensing Arrangements and Collaborative Arrangements - Licensing Arrangements (Details) - USD ($)
$ in Millions
 1 Months Ended 3 Months Ended 12 Months Ended
Nov. 30, 2019
Jun. 28, 2020
Dec. 31, 2021
Apr. 30, 2020
Valneva [Member] | Licensing Agreements [Member]        
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]        
Maximum potential consideration       $ 308
Potential development milestones       35
Potential early commercialization milestones       $ 143
Development cost ownership percentage     30.00%  
Valneva [Member] | Research and Development Expense [Member] | Licensing Agreements [Member]        
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]        
Payment for licensing arrangement   $ 130    
Licensing Agreements [Member] | Akcea And Ionis [Member] | Research and Development Expense [Member]        
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]        
Payment for licensing arrangement $ 250      
v3.22.0.1
Acquisitions, Divestitures, Equity-Method Investments, Licensing Arrangements and Collaborative Arrangements - Collaborative Arrangements (Detail) - USD ($)
 1 Months Ended 3 Months Ended 12 Months Ended
Dec. 31, 2021
Dec. 30, 2021
Dec. 24, 2021
Jul. 21, 2021
Dec. 26, 2020
Apr. 09, 2020
Jul. 31, 2021
Dec. 31, 2020
Apr. 30, 2020
Dec. 31, 2021
Oct. 03, 2021
Jun. 28, 2020
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Sep. 29, 2020
Jul. 31, 2020
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]                                  
Finite-lived intangible assets, gross carrying amount $ 76,552,000,000             $ 76,255,000,000   $ 76,552,000,000     $ 76,552,000,000 $ 76,255,000,000      
Research and development expenses [1]                         13,829,000,000 9,393,000,000 $ 8,385,000,000    
Developed Technology Rights [Member]                                  
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]                                  
Finite-lived intangible assets, gross carrying amount [2] $ 73,346,000,000             73,040,000,000   73,346,000,000     73,346,000,000 73,040,000,000      
Collaborative Arrangement [Member]                                  
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]                                  
Research and development expenses [3]                         $ 742,000,000 $ 192,000,000 $ (104,000,000)    
Collaborative Arrangement [Member] | Arvinas, Inc [Member]                                  
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]                                  
Ownership percentage 6.50%                                
Collaborative Arrangement [Member] | CStone [Member]                                  
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]                                  
Committed investment from collaborator                               $ 200,000,000  
Ownership percentage                         9.80%        
Collaborative Arrangement [Member] | BioNTech [Member]                                  
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]                                  
Ownership percentage                         2.50%        
Collaborative Arrangement [Member] | Beam [Member]                                  
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]                                  
Development cost ownership percentage     65.00%                            
Potential future milestone payments     $ 1,050,000,000.00                            
Maximum potential consideration     $ 1,350,000,000                            
Collaborative Arrangement [Member] | Beam [Member] | Research and Development Expense [Member]                                  
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]                                  
Payment to collaborators                   $ 300,000,000              
Collaborative Arrangement [Member] | Beam [Member] | Beam [Member]                                  
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]                                  
Development cost ownership percentage     35.00%                            
Collaborative Arrangement [Member] | Arvinas, Inc [Member]                                  
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]                                  
Committed investment from collaborator       $ 350,000,000                          
Collaborative arrangement, milestone payment upon approval (up to)       400,000,000                          
Collaborative arrangement, milestone payment upon commercializing       1,000,000,000                          
Collaborative Arrangement [Member] | Arvinas, Inc [Member] | Research and Development Expense [Member]                                  
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]                                  
Cash payment to collaborators       $ 650,000,000                          
Upfront payment and premium paid in equity investment                     $ 706,000,000            
Collaborative Arrangement [Member] | Myovant [Member]                                  
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]                                  
Payment to collaborators             $ 100,000,000 $ 650,000,000                  
Maximum reimbursement due from collaborators, 2021         $ 100,000,000                        
Maximum reimbursement due from collaborators, 2022         50,000,000                        
Potential milestone payments         4,350,000,000                        
Milestone payments         200,000,000                        
Collaborative Arrangement, tiered sales milestone payments         3,500,000,000                        
Research and development expenses         151,000,000                        
Collaborative Arrangement [Member] | Myovant [Member] | Developed Technology Rights [Member]                                  
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]                                  
Finite-lived intangible assets, gross carrying amount         $ 499,000,000                        
Collaborative Arrangement [Member] | BioNTech [Member]                                  
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]                                  
Committed investment from collaborator                                 $ 50,000,000
Proceeds received from upfront payments and milestone payments                         $ 188,000,000        
Collaborative Arrangement [Member] | BioNTech [Member] | Shingles Vaccine Program, mRNA-Based [Member]                                  
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]                                  
Payment to collaborators   $ 225,000,000                              
Potential future milestone payments   200,000,000                              
Committed investment from collaborator   150,000,000                              
Collaborative Arrangement [Member] | BioNTech [Member] | Shingles Vaccine Program, mRNA-Based [Member] | Research and Development Expense [Member]                                  
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]                                  
Cash payment to collaborators   75,000,000                              
Proceeds received from upfront payments and milestone payments   $ 25,000,000                              
Collaborative Arrangement [Member] | BioNTech [Member] | Coronavirus Vaccine Program, mRNA-Based [Member]                                  
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]                                  
Potential future milestone payments           $ 563,000,000                      
Maximum potential consideration           $ 748,000,000                      
Cash payment to collaborators                 $ 72,000,000                
Committed investment from collaborator                 $ 113,000,000                
Percentage of costs to be reimbursed           50.00%                      
Collaborative Arrangement [Member] | BioNTech [Member] | Coronavirus Vaccine Program, mRNA-Based [Member] | Research and Development Expense [Member]                                  
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]                                  
Upfront payment and premium paid in equity investment                       $ 98,000,000          
[1] Exclusive of amortization of intangible assets, except as disclosed in Note 1M.
[2] The increase in the gross carrying amount primarily reflects $500 million of capitalized Comirnaty sales milestones to BioNTech, partially offset by net losses from foreign currency translation adjustments.
[3] Primarily relates to upfront payments and pre-approval milestone payments earned by our partners as well as net reimbursements.
v3.22.0.1
Acquisitions, Divestitures, Equity-Method Investments, Licensing Arrangements and Collaborative Arrangements - Schedule of Collaborative Arrangements and Non-collaborative Arrangement Transactions (Details) - USD ($)
$ in Millions
 12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]      
Revenues [1] $ 81,288 $ 41,651 $ 40,905
Cost of sales [2] (30,821) (8,484) (8,054)
Selling, informational and administrative expenses [2] (12,703) (11,597) (12,726)
Research and development expenses [2] (13,829) (9,393) (8,385)
Other income/(deductions)—net 4,878 (1,219) (3,497)
Collaborative Arrangement [Member]      
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]      
Revenues 8,241 5,703 4,953
Cost of sales [3] (16,169) (61) (52)
Selling, informational and administrative expenses [4] (175) (194) (176)
Research and development expenses [5] (742) (192) 104
Other income/(deductions)—net [6] 820 567 362
Product [Member] | Collaborative Arrangement [Member]      
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]      
Revenues [7] 590 284 305
Co-promotion [Member] | Collaborative Arrangement [Member]      
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]      
Revenues [8] $ 7,652 $ 5,418 $ 4,648
[1] On December 31, 2021, we completed the sale of our Meridian subsidiary. Prior to its sale, Meridian was managed as part of the Hospital therapeutic area. On November 16, 2020, we completed the spin-off and the combination of our Upjohn Business with Mylan to form Viatris. On December 21, 2020, Pfizer and Viatris completed the termination of the Mylan-Japan collaboration. Beginning in the fourth quarter of 2021, the financial results of Meridian are reflected as discontinued operations for all periods presented. Beginning in the fourth quarter of 2020, the financial results of the Upjohn Business and Mylan-Japan collaboration were reflected as discontinued operations for all periods presented. Prior-period financial information has been restated, as appropriate. See Note 1A.
[2] Exclusive of amortization of intangible assets, except as disclosed in Note 1M.
[3] Primarily relates to amounts paid to collaboration partners for their share of net sales or profits earned in collaboration arrangements where we are the principal in the transaction, and cost of sales for inventory purchased from our partners. The increase in 2021 is primarily related to Comirnaty.
[4] Represents net reimbursements to our partners for selling, informational and administrative expenses incurred.
[5] Primarily relates to upfront payments and pre-approval milestone payments earned by our partners as well as net reimbursements.
[6] Primarily relates to royalties from our collaboration partners.
[7] Represents sales to our partners of products manufactured by us.
[8] Substantially all relates to amounts earned from our partners under co-promotion agreements. The increase in 2021 reflects increases in alliance revenues from Comirnaty, Eliquis and Xtandi, while the increase in 2020 reflects increases in alliance revenues from Eliquis and Xtandi.
v3.22.0.1
Restructuring Charges and Other Costs Associated with Acquisitions and Cost-Reduction/Productivity Initiatives - Narrative (Detail) - USD ($)
$ in Millions
 12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Restructuring Cost and Reserve [Line Items]      
Total costs incurred $ 1,298 $ 838 $ 820
Business Integration Costs [Member]      
Restructuring Cost and Reserve [Line Items]      
Restructuring costs (income)     (197)
Focused Company Plan [Member]      
Restructuring Cost and Reserve [Line Items]      
Restructuring cost incurred to date 2,200    
Restructuring costs (income)     87
Focused Company Plan [Member] | Biopharma [Member]      
Restructuring Cost and Reserve [Line Items]      
Restructuring cost incurred to date 856    
Restructuring costs (income) 712 $ 79 64
Focused Company Plan [Member] | Corporate Enabling Functions [Member]      
Restructuring Cost and Reserve [Line Items]      
Expected cost 1,600    
Focused Company Plan [Member] | Go-to Market Model [Member]      
Restructuring Cost and Reserve [Line Items]      
Expected cost 1,100    
Focused Company Plan [Member] | Manufacturing Optimization [Member]      
Restructuring Cost and Reserve [Line Items]      
Expected cost $ 800    
Percentage of non-cash restructuring charges expected 25.00%    
2017-2019 and Organizing for Growth [Member]      
Restructuring Cost and Reserve [Line Items]      
Restructuring costs (income)     548
Array [Member] | Business Integration Costs [Member]      
Restructuring Cost and Reserve [Line Items]      
Restructuring costs (income)     288
Hospira [Member] | Business Integration Costs [Member]      
Restructuring Cost and Reserve [Line Items]      
Restructuring costs (income)     $ 94
v3.22.0.1
Restructuring Charges and Other Costs Associated with Acquisitions and Cost-Reduction/Productivity Initiatives - Costs (Detail) - USD ($)
$ in Millions
 12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Restructuring charges:      
Employee terminations $ 680 $ 474 $ 108
Asset impairments 53 66 69
Exit costs/(credits) 8 (6) 50
Total restructuring charges/(credits) [1] 741 535 227
Transaction costs [2] 20 10 63
Integration costs and other [3] 41 34 311
Restructuring charges and certain acquisition-related costs 802 579 601
Additional depreciation - asset restructuring, virtually all of which is recorded in Cost of sales [4] 87 17 40
Implementation costs recorded in our consolidated statements of income as follows:      
Implementation costs [5] 472 238 156
Total costs associated with acquisitions and cost-reduction/productivity initiatives 1,298 838 820
Other Nonoperating Income (Expense) [Member]      
Restructuring charges:      
Net periodic benefit costs recorded in Other (income)/deductions––net [6] (63) 3 23
Cost of Sales [Member]      
Restructuring charges:      
Additional depreciation - asset restructuring, virtually all of which is recorded in Cost of sales [4] 63 21 29
Implementation costs recorded in our consolidated statements of income as follows:      
Implementation costs [5] 45 40 61
Selling, Informational and Administrative Expenses [Member]      
Restructuring charges:      
Additional depreciation - asset restructuring, virtually all of which is recorded in Cost of sales [4] 23 0 3
Implementation costs recorded in our consolidated statements of income as follows:      
Implementation costs [5] 426 197 73
Research and Development Expense [Member]      
Restructuring charges:      
Additional depreciation - asset restructuring, virtually all of which is recorded in Cost of sales [4] 0 (3) 8
Implementation costs recorded in our consolidated statements of income as follows:      
Implementation costs [5] $ 1 $ 1 $ 22
[1] Represents acquisition-related costs ($9 million credit in 2021 and $192 million credit in 2019) and cost reduction initiatives ($750 million charge in 2021, $535 million charge in 2020, and $418 million charge in 2019). 2021 and 2020 charges mainly represent employee termination costs for our Transforming to a More Focused Company cost-reduction program. 2019 restructuring charges mainly represent employee termination costs for cost-reduction and productivity initiatives, partially offset by the reversal of certain accruals related to our acquisition of Wyeth upon the effective favorable settlement of an IRS audit for multiple tax years (see Note 5B). The employee termination costs for 2019 were primarily for our improvements to operational effectiveness as part of the realignment of our business structure, and also included employee termination costs for the Transforming to a More Focused Company cost-reduction program.
[2] Represents external costs for banking, legal, accounting and other similar services.
[3] Represents external, incremental costs directly related to integrating acquired businesses, such as expenditures for consulting and the integration of systems and processes, and certain other qualifying costs. 2021 costs primarily related to our acquisition of Trillium. 2020 costs primarily related to our acquisition of Array. 2019 costs mainly related to our acquisitions of Array, including $157 million in payments to Array employees for the fair value of previously unvested stock options that was recognized as post-closing compensation expense (see Note 2A), and Hospira.
[4] Represents the impact of changes in the estimated useful lives of assets involved in restructuring actions.
[5] Represents external, incremental costs directly related to implementing our non-acquisition-related cost-reduction/productivity initiatives.
[6] (d)Amounts include the impact of a change in accounting principle. See Note 1C.
v3.22.0.1
Restructuring Charges and Other Costs Associated with Acquisitions and Cost-Reduction/Productivity Initiatives - Costs - Footnotes (Detail) - USD ($)
$ in Millions
 12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Restructuring Cost and Reserve [Line Items]      
Restructuring charge (credit) [1] $ 741 $ 535 $ 227
Acquisition-related Costs [Member]      
Restructuring Cost and Reserve [Line Items]      
Restructuring charge (credit) (9)   (192)
Cost Reduction Initiatives [Member]      
Restructuring Cost and Reserve [Line Items]      
Restructuring charge (credit) $ 750 $ 535 418
Restructuring Charges And Acquisition-Related Costs [Member] | Array [Member]      
Restructuring Cost and Reserve [Line Items]      
Post closing compensation expense     $ 157
[1] Represents acquisition-related costs ($9 million credit in 2021 and $192 million credit in 2019) and cost reduction initiatives ($750 million charge in 2021, $535 million charge in 2020, and $418 million charge in 2019). 2021 and 2020 charges mainly represent employee termination costs for our Transforming to a More Focused Company cost-reduction program. 2019 restructuring charges mainly represent employee termination costs for cost-reduction and productivity initiatives, partially offset by the reversal of certain accruals related to our acquisition of Wyeth upon the effective favorable settlement of an IRS audit for multiple tax years (see Note 5B). The employee termination costs for 2019 were primarily for our improvements to operational effectiveness as part of the realignment of our business structure, and also included employee termination costs for the Transforming to a More Focused Company cost-reduction program.
v3.22.0.1
Restructuring Charges and Other Costs Associated with Acquisitions and Cost-Reduction/Productivity Initiatives - Restructuring Accruals (Detail) - USD ($)
$ in Millions
 12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Restructuring Reserve [Roll Forward]      
Beginning balance $ 798 [1] $ 816  
Provision [2] 741 535 $ 227
Utilization and other [3] (468) (554)  
Ending balance 1,071 [4] 798 [1] 816
Employee Termination Costs [Member]      
Restructuring Reserve [Roll Forward]      
Beginning balance 782 [1] 770  
Provision 680 474  
Utilization and other [3] (449) (462)  
Ending balance 1,014 [4] 782 [1] 770
Asset Impairment Charges [Member]      
Restructuring Reserve [Roll Forward]      
Beginning balance 0 [1] 0  
Provision 53 66  
Utilization and other [3] (53) (66)  
Ending balance 0 [4] 0 [1] 0
Exit Costs [Member]      
Restructuring Reserve [Roll Forward]      
Beginning balance 15 [1] 46  
Provision 8 (6)  
Utilization and other [3] 34 (25)  
Ending balance $ 57 [4] $ 15 [1] $ 46
[1] Included in Other current liabilities ($628 million) and Other noncurrent liabilities ($169 million).
[2] Represents acquisition-related costs ($9 million credit in 2021 and $192 million credit in 2019) and cost reduction initiatives ($750 million charge in 2021, $535 million charge in 2020, and $418 million charge in 2019). 2021 and 2020 charges mainly represent employee termination costs for our Transforming to a More Focused Company cost-reduction program. 2019 restructuring charges mainly represent employee termination costs for cost-reduction and productivity initiatives, partially offset by the reversal of certain accruals related to our acquisition of Wyeth upon the effective favorable settlement of an IRS audit for multiple tax years (see Note 5B). The employee termination costs for 2019 were primarily for our improvements to operational effectiveness as part of the realignment of our business structure, and also included employee termination costs for the Transforming to a More Focused Company cost-reduction program.
[3] Includes adjustments for foreign currency translation.
[4] Included in Other current liabilities ($816 million) and Other noncurrent liabilities ($255 million).
v3.22.0.1
Restructuring Charges and Other Costs Associated with Acquisitions and Cost-Reduction/Productivity Initiatives - Restructuring Accruals - Footnotes (Detail) - USD ($)
$ in Millions
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Restructuring Cost and Reserve [Line Items]      
Restructuring reserve $ 1,071 [1] $ 798 [2] $ 816
Other Current Liabilities [Member]      
Restructuring Cost and Reserve [Line Items]      
Restructuring reserve 816 628  
Other Noncurrent Liabilities [Member]      
Restructuring Cost and Reserve [Line Items]      
Restructuring reserve $ 255 $ 169  
[1] Included in Other current liabilities ($816 million) and Other noncurrent liabilities ($255 million).
[2] Included in Other current liabilities ($628 million) and Other noncurrent liabilities ($169 million).
v3.22.0.1
Other (Income)/Deductions - Net - Schedule of Other Nonoperating Income (Expense) (Details) - USD ($)
$ in Millions
 12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Other Income and Expenses [Abstract]      
Interest income $ (36) $ (73) $ (225)
Interest expense [1] 1,291 1,449 1,573
Net interest expense 1,255 1,376 1,348
Royalty-related income (857) (770) (646)
Net (gains)/losses on asset disposals (99) 237 (32)
Net (gains)/losses recognized during the period on equity securities [2],[3] (1,344) (540) (454)
Income from collaborations, out-licensing arrangements and sales of compound/product rights [4] (396) (326) (168)
Net periodic benefit costs/(credits) other than service costs [5] (2,547) 311 305
Certain legal matters, net [6] 182 28 292
Certain asset impairments [7] 86 1,691 2,792
Business and legal entity alignment costs [8] 0 0 300
Consumer Healthcare JV equity method (income)/loss [9] (471) (298) (17)
Other, net [10] (687) (491) (224)
Other (income)/deductions––net $ (4,878) $ 1,219 $ 3,497
[1] Capitalized interest totaled $108 million in 2021, $96 million in 2020 and $88 million in 2019.
[2] Reported in Other (income)/deductions––net. See Note 4.
[3] (b)2021 gains include, among other things, unrealized gains of $1.6 billion related to investments in BioNTech and Cerevel. 2020 gains included, among other things, unrealized gains of $405 million related to investments in BioNTech and SpringWorks Therapeutics, Inc. (SpringWorks). 2019 gains included, among other things, unrealized gains of $295 million related to investments in Cortexyme, Inc. and SpringWorks.
[4] 2021 includes, among other things, $188 million of net collaboration income from BioNTech related to the COVID-19 vaccine and $97 million of milestone income from multiple licensees. 2020 included, among other things, (i) a $75 million upfront payment received from our sale of our CK1 assets to Biogen, (ii) $40 million of milestone income from Puma Biotechnology, Inc. related to Neratinib regulatory approvals in the EU, (iii) $30 million of milestone income from Lilly related to the first commercial sale in the U.S. of LOXO-292 for the treatment of RET fusion-positive NSCLC and (iv) $108 million in milestone income from multiple licensees. 2019 included, among other things, $78 million in milestone income from Mylan Pharmaceuticals Inc. related to the FDA’s approval and launch of Wixela Inhub®, a generic of Advair Diskus®(fluticasone propionate and salmeterol inhalation powder) and $52 million in milestone income from multiple licensees.
[5] Amounts include the impact of a change in accounting principle. See Notes 1C and 11. In 2019, other non-service cost components’ activity related to the Consumer Healthcare JV transaction, such as gain on settlements, were recorded in (Gain) on completion of Consumer Healthcare JV transaction.
[6] Includes legal reserves for certain pending legal matters.
[7] 2020 represents intangible asset impairment charges associated with our Biopharma segment: (i) $900 million related to IPR&D assets for unapproved indications of certain cancer medicines, acquired in our Array acquisition, and reflected, among other things, updated commercial forecasts; (ii) $528 million related to Eucrisa, a finite-lived developed technology right acquired in our Anacor acquisition, and reflected updated commercial forecasts mainly reflecting competitive pressures; and (iii) $263 million related to finite-lived developed technology rights for certain generic sterile injectables acquired in our Hospira acquisition, and reflected updated commercial forecasts mainly reflecting competitive pressures.2019 primarily included intangible asset impairment charges of $2.8 billion, mainly composed of $2.6 billion, related to Eucrisa, and reflected updated commercial forecasts mainly reflecting competitive pressures.
[8] Mainly represents incremental costs for the design, planning and implementation of our then new business structure, effective in the beginning of 2019, and primarily includes consulting, legal, tax and other advisory services.
[9] See Note 2C.
[10] 2021 includes, among other things, (i) income net of costs associated with TSAs of $288 million; (ii) dividend income of $166 million from our investment in ViiV and (iii) charges of $142 million, reflecting the change in the fair value of contingent consideration. 2020 included, among other things, (i) dividend income of $278 million from our investment in ViiV; (ii) income net of costs associated with TSAs of $114 million and (iii) charges of $105 million, reflecting the change in the fair value of contingent consideration. 2019 included, among other things, (i) dividend income of $220 million from our investment in ViiV; (ii) charges of $152 million for external incremental costs, such as transaction costs and costs to separate our Consumer Healthcare business into a separate legal entity, associated with the formation of the Consumer Healthcare JV; and (iii) net losses on early retirement of debt of $138 million.
v3.22.0.1
Other (Income)/Deductions - Net - Schedule of Other Nonoperating Income (Expense) - Footnotes (Details) - USD ($)
$ in Millions
 12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Derivative [Line Items]      
Interest costs capitalized $ 108 $ 96 $ 88
Unrealized gain on equity securities [1] 1,264 515 429
Intangible asset impairments   1,700 2,800
Other income, net [2] 687 491 224
External incremental costs     152
Net losses on early retirement of debt     (138)
Transition Service Agreement [Member]      
Derivative [Line Items]      
Other income, net 288 114  
Licensing Agreements [Member] | Other Nonoperating Income (Expense) [Member]      
Derivative [Line Items]      
Proceeds received from upfront payments and milestone payments 97 108 52
BioNTech [Member] | Collaborative Arrangement [Member]      
Derivative [Line Items]      
Proceeds received from upfront payments and milestone payments 188    
Puma Technologies [Member] | Collaborative Arrangement [Member]      
Derivative [Line Items]      
Proceeds received from upfront payments and milestone payments   40  
Eli Lilly & Company [Member] | Collaborative Arrangement [Member]      
Derivative [Line Items]      
Proceeds received from upfront payments and milestone payments   30  
Mylan [Member] | Collaborative Arrangement [Member]      
Derivative [Line Items]      
Proceeds received from upfront payments and milestone payments     78
Disposed of by Sale, Not Discontinued Operations [Member] | CK1 Assets Sold To Biogen, Inc [Member]      
Derivative [Line Items]      
Cash received for disposition   75  
BioNTech and Cerevel Therapeutics, LLC [Member]      
Derivative [Line Items]      
Unrealized gain on equity securities 1,600    
BioNTech and SpringWorks [Member]      
Derivative [Line Items]      
Unrealized gain on equity securities   405  
Cortexyme, Inc. and SpringWorks [Member]      
Derivative [Line Items]      
Unrealized gain on equity securities     295
ViiV [Member]      
Derivative [Line Items]      
Dividend income 166 278 220
Array [Member] | IPR&D [Member] | Biopharma [Member]      
Derivative [Line Items]      
Intangible asset impairments   900  
Anacor [Member] | Developed Technology Rights [Member] | Eucrisa [Member]      
Derivative [Line Items]      
Intangible asset impairments     $ 2,600
Anacor [Member] | Developed Technology Rights [Member] | Eucrisa [Member] | Biopharma [Member]      
Derivative [Line Items]      
Intangible asset impairments   528  
Hospira [Member] | Developed Technology Rights [Member] | Generic Sterile Injectable Product [Member] | Biopharma [Member]      
Derivative [Line Items]      
Intangible asset impairments   263  
ViiV [Member]      
Derivative [Line Items]      
Change in fair value of fair value contingent consideration liabilities $ 142 $ 105  
[1] Included in net unrealized gains are observable price changes on equity securities without readily determinable fair values. As of December 31, 2021, there were cumulative impairments and downward adjustments of $97 million and upward adjustments of $156 million. Impairments, downward and upward adjustments were not significant in 2021, 2020 and 2019
[2] 2021 includes, among other things, (i) income net of costs associated with TSAs of $288 million; (ii) dividend income of $166 million from our investment in ViiV and (iii) charges of $142 million, reflecting the change in the fair value of contingent consideration. 2020 included, among other things, (i) dividend income of $278 million from our investment in ViiV; (ii) income net of costs associated with TSAs of $114 million and (iii) charges of $105 million, reflecting the change in the fair value of contingent consideration. 2019 included, among other things, (i) dividend income of $220 million from our investment in ViiV; (ii) charges of $152 million for external incremental costs, such as transaction costs and costs to separate our Consumer Healthcare business into a separate legal entity, associated with the formation of the Consumer Healthcare JV; and (iii) net losses on early retirement of debt of $138 million.
v3.22.0.1
Tax Matters - Income from Continuing Operations Before Provision for Taxes on Income (Details) - USD ($)
$ in Millions
 12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Income Tax Disclosure [Abstract]      
United States $ 6,064 $ (2,887) $ 7,332
International 18,247 9,924 3,988
Income from continuing operations before provision/(benefit) for taxes on income [1],[2],[3] $ 24,311 $ 7,036 $ 11,321
[1] Income from continuing operations before provision/(benefit) for taxes on income. Biopharma’s earnings include dividend income from our investment in ViiV of $166 million in 2021, $278 million in 2020 and $220 million in 2019.
[2] 2020 v. 2019––The domestic loss in 2020 versus domestic income in 2019 was mainly related to the non-recurrence of the gain on the completion of the Consumer Healthcare JV transaction as well as higher asset impairment charges and higher R&D expenses. The increase in the international income was primarily related to the non-recurrence of the write off of assets contributed to the Consumer Healthcare JV as well as lower asset impairment charges and lower amortization of intangible assets.
[3] 2021 v. 2020––The domestic income in 2021 versus domestic loss in 2020 was mainly related to Comirnaty income, lower asset impairment charges, net periodic benefit credits in 2021 versus net periodic benefit costs in 2020 and higher net gains from equity securities, partially offset by higher R&D expenses. The increase in the international income was primarily related to Comirnaty income, net periodic benefit credits in 2021 versus net periodic benefit costs in 2020 and lower asset impairment charges.
v3.22.0.1
Tax Matters - Provision for Taxes on Income (Details) - USD ($)
$ in Millions
 12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Current income taxes:      
Federal $ 3,342 $ 372 $ (1,887)
State and local 34 56 (186)
Deferred income taxes:      
Federal (3,850) (1,164) 1,254
State and local (491) (131) 276
Total U.S. tax benefit (964) (867) (543)
TCJA      
Current income taxes 0 0 (135)
Deferred Income taxes 0 0 (187)
Total TCJA tax benefit 0 0 (323)
International      
Current income taxes 2,769 1,517 2,418
Deferred income taxes 48 (279) (969)
Total international tax provision 2,816 1,237 1,449
Provision/(benefit) for taxes on income $ 1,852 $ 370 $ 583
v3.22.0.1
Tax Matters - Narrative (Details) - USD ($)
$ in Millions
 3 Months Ended 12 Months Ended
Sep. 29, 2019
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Income Tax Contingency [Line Items]        
Repatriation tax liability   $ 15,000    
Tax benefit from IRS settlement       $ 1,400
Deconsolidation gain $ 2,700      
Unremitted earnings of international subsidiaries   55,000    
Unrecognized tax benefits excluding associated interest   4,500 $ 4,300  
Deferred tax assets associated with unrecognized tax benefits   1,500 1,300  
Increase (decrease) of interest on income taxes expense   108 89 $ (564)
Unrecognized tax benefits, interest on income taxes accrued   601 493  
Unrecognized accrued interest decrease as a result of cash payments   1 5  
Unrecognized tax benefits, interest on income taxes accrued, decrease resulting from divestiture     75  
Decrease in unrecognized tax benefits is reasonably possible, amount of unrecorded benefit   75    
Noncurrent Deferred Tax Assets And Other Noncurrent Tax Assets [Member]        
Income Tax Contingency [Line Items]        
Deferred tax assets associated with unrecognized tax benefits   1,400 1,100  
Other Taxes Payable [Member]        
Income Tax Contingency [Line Items]        
Deferred tax assets associated with unrecognized tax benefits   $ 105 46  
Deferred Tax Liabilities, Net, Noncurrent [Member]        
Income Tax Contingency [Line Items]        
Deferred tax assets associated with unrecognized tax benefits     $ 122  
v3.22.0.1
Tax Matters - Tax Rate Reconciliation (Details)
 12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Income Tax Disclosure [Abstract]      
U.S. statutory income tax rate 21.00% 21.00% 21.00%
TCJA impact [1] 0 0 (0.029)
Taxation of non-U.S. operations [2],[3] (4.30%) (9.90%) (4.70%)
Tax settlements and resolution of certain tax positions [1] (0.40%) (2.70%) (14.00%)
Completion of Consumer Healthcare JV transaction [1] 0.00% 0.00% 8.30%
Certain Consumer Healthcare JV initiatives [1] (6.00%) 0.00%  
U.S. R&D tax credit (0.50%) (1.40%) (0.80%)
Interest [4] 0.40% 1.10% 0.60%
All other, net [5] (2.60%) (2.80%) (2.30%)
Effective tax rate for income from continuing operations 7.60% 5.30% 5.20%
[1] See Note 5A.
[2] For taxation of non-U.S. operations, this rate impact reflects the income tax rates and relative earnings in the locations where we do business outside the U.S., together with the U.S. tax cost on our international operations, changes in uncertain tax positions not included in the reconciling item called “Tax settlements and resolution of certain tax positions,” as well as changes in valuation allowances. Specifically: (i) the jurisdictional location of earnings is a significant component of our effective tax rate each year, and the rate impact of this component is influenced by the specific location of non-U.S. earnings and the level of such earnings as compared to our total earnings; (ii) the U.S. tax implications of our foreign operations is a significant component of our effective tax rate each year and generally offsets some of the reduction to our effective tax rate each year resulting from the jurisdictional location of earnings; (iii) the impact of certain tax initiatives; and (iv) the impact of changes in uncertain tax positions not included in the reconciling item called “Tax settlements and resolution of certain tax positions” is a component of our effective tax rate each year that can result in either an increase or decrease to our effective tax rate. The jurisdictional mix of earnings, which includes the impact of the location of earnings as well as the U.S. tax cost on our international operations, can vary as a result of operating fluctuations in the normal course of business and as a result of the extent and location of other income and expense items, such as restructuring charges, asset impairments and gains and losses on strategic business decisions. See also Note 5A for the components of pre-tax income and Provision/(benefit) for taxes on income, which is based on the location of the taxing authorities, and for information about settlements and other items impacting Provision/(benefit) for taxes on income.
[3] In all years, the reduction in our effective tax rate is a result of the jurisdictional location of earnings and is largely due to lower tax rates in certain jurisdictions, as well as manufacturing and other incentives for our subsidiaries in Singapore and, to a lesser extent, in Puerto Rico. We benefit from Puerto Rican tax incentives pursuant to a grant that expires during 2029. Under such grant, we are partially exempt from income, property and municipal taxes. In Singapore, we benefit from incentive tax rates effective through 2047 on income from manufacturing and other operations.
[4] Includes changes in interest related to our uncertain tax positions not included in the reconciling item called “Tax settlements and resolution of certain tax positions”.
[5] All other, net is primarily due to routine business operations.
v3.22.0.1
Tax Matters - Deferred Taxes (Details) - USD ($)
$ in Millions
Dec. 31, 2021
Dec. 31, 2020
Deferred Tax Assets    
Prepaid/deferred items - Deferred tax assets [1],[2] $ 4,086 $ 3,114
Inventories - Deferred tax assets [1] 408 276
Intangible assets - Deferred tax assets [1],[3] 1,778 793
Property, plant and equipment - Deferred tax assets [1],[4] 117 211
Employee benefits - Deferred tax assets [1],[5] 1,594 1,981
Restructurings and other charges - Deferred tax assets [1] 303 291
Legal and product liability reserves - Deferred tax assets [1] 373 382
Net operating loss/credit carryforwards - Deferred tax assets [1],[6] 1,431 1,761
State and local tax adjustments - Deferred tax assets [1] 197 171
Investments - Deferred tax assets [1],[7] 70 130
All other - Deferred tax assets [1] 89 80
Subtotal - Deferred tax assets [1] 10,446 9,190
Valuation allowance [1] (1,462) (1,586)
Total deferred taxes - Deferred tax assets [1] 8,983 7,604
Deferred Tax Liabilities    
Prepaid/deferred items - Deferred tax liabilities [1],[2] (456) (336)
Inventories - Deferred tax liabilities [1] (56) (25)
Intangible assets - Deferred tax liabilities [1],[3] (4,577) (5,355)
Property, plant and equipment - Deferred tax liabilities [1],[4] (1,647) (1,220)
Employee benefits - Deferred tax liabilities [1],[5] (178) (124)
Unremitted earnings - Deferred tax liabilities [1] (45) (46)
Investments - Deferred tax liabilities [1],[7] (689) (3,545)
All other - Deferred tax liabilities [1] (68) (76)
Deferred tax liabilities, gross [1] (7,714) (10,726)
Net deferred tax asset [1],[8] $ 1,269  
Net deferred tax liability [1],[8]   $ (3,123)
[1] The deferred tax assets and liabilities associated with global intangible low-taxed income are included in the relevant categories. See Note 1Q.
[2] The increase in net deferred tax assets in 2021 is primarily related to temporary differences associated with Comirnaty royalty accruals and the result of operating lease ROU liabilities recognized during the period.
[3] The increase in the deferred tax assets is primarily due to the acquisition of intangible assets relating to Trillium and the decrease in the 2021 deferred tax liabilities is primarily the result of amortization of intangible assets.
[4] The increase in net deferred tax liabilities in 2021 is primarily the result of operating lease ROU assets recognized during the period. See Note 15.
[5] The decrease in net deferred tax assets in 2021 is primarily the result of favorable pension plan asset performance reported in the period. See Note 11A.
[6] The amounts in 2021 and 2020 are reduced for unrecognized tax benefits of $3.0 billion and $3.0 billion, respectively, where we have net operating loss carryforwards, similar tax losses, and/or tax credit carryforwards that are available, under the tax law of the applicable jurisdiction, to settle any additional income taxes that would result from the disallowance of a tax position.
[7] The decrease in net deferred tax liabilities in 2021 is primarily due to certain initiatives executed in the third quarter of 2021 associated with our investment in the Consumer Healthcare JV.
[8] In 2021, Noncurrent deferred tax assets and other noncurrent tax assets ($1.6 billion), and Noncurrent deferred tax liabilities ($0.3 billion). In 2020, Noncurrent deferred tax assets and other noncurrent tax assets ($0.9 billion), and Noncurrent deferred tax liabilities ($4.1 billion).
v3.22.0.1
Tax Matters - Deferred Taxes - Footnotes (Details) - USD ($)
$ in Millions
 12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Income Tax Examination [Line Items]    
Reduction for unrecognized tax benefit $ 3,000 $ 3,000
Net deferred tax liability [1],[2]   3,123
Noncurrent Deferred Tax Assets And Other Noncurrent Tax Assets [Member]    
Income Tax Examination [Line Items]    
Net deferred tax liability 1,600 900
Noncurrent Deferred Tax Liabilities [Member]    
Income Tax Examination [Line Items]    
Net deferred tax liability $ 300 $ 4,100
[1] In 2021, Noncurrent deferred tax assets and other noncurrent tax assets ($1.6 billion), and Noncurrent deferred tax liabilities ($0.3 billion). In 2020, Noncurrent deferred tax assets and other noncurrent tax assets ($0.9 billion), and Noncurrent deferred tax liabilities ($4.1 billion).
[2] The deferred tax assets and liabilities associated with global intangible low-taxed income are included in the relevant categories. See Note 1Q.
v3.22.0.1
Tax Matters - Reconciliation of Gross Unrecognized Tax Benefits (Details) - USD ($)
$ in Millions
 12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Reconciliation of Unrecognized Tax Benefits, Excluding Amounts Pertaining to Examined Tax Returns [Roll Forward]      
Balance, beginning $ (5,595) [1] $ (5,381) [1] $ (6,259)
Acquisitions 0 37 (44)
Divestitures [2] 0 265 0
Increases based on tax positions taken during a prior period [3] (111) (232) (36)
Decreases based on tax positions taken during a prior period [3],[4] 103 64 1,109
Decreases based on settlements for a prior period [5] 24 15 100
Increases based on tax positions taken during the current period [3] (550) (411) (383)
Impact of foreign exchange 22 (72) 25
Other, net [3],[6] 40 120 107
Balance, ending [1] $ (6,068) $ (5,595) $ (5,381)
[1] In 2021, included in Income taxes payable ($19 million), Other current assets ($42 million) Noncurrent deferred tax assets and other noncurrent tax assets ($3.0 billion), Noncurrent deferred tax liabilities ($5 million) and Other taxes payable ($3.0 billion). In 2020, included in Income taxes payable ($34 million), Noncurrent deferred tax assets and other noncurrent tax assets ($18 million), Noncurrent deferred tax liabilities ($3.0 billion) and Other taxes payable ($2.5 billion).
[2] For 2020, related to the separation of Upjohn. See Note 2B.
[3] Primarily included in Provision/(benefit) for taxes on income.
[4] Primarily related to effectively settling certain issues with the U.S. and foreign tax authorities. See Note 5A.
[5] Primarily related to cash payments and reductions of tax attributes.
[6] Primarily related to decreases as a result of a lapse of applicable statutes of limitations.
v3.22.0.1
Tax Matters - Reconciliation of Gross Unrecognized Tax Benefits - Footnotes (Details) - USD ($)
$ in Millions
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
 [1]
Dec. 31, 2018
Income Tax Contingency [Line Items]        
Unrecognized tax benefits $ 6,068 [1] $ 5,595 [1] $ 5,381 $ 6,259
Income Taxes Payable [Member]        
Income Tax Contingency [Line Items]        
Unrecognized tax benefits 19 34    
Other Current Tax Assets [Member]        
Income Tax Contingency [Line Items]        
Unrecognized tax benefits 42      
Noncurrent Deferred Tax Assets And Other Noncurrent Tax Assets [Member]        
Income Tax Contingency [Line Items]        
Unrecognized tax benefits 3,000 18    
Noncurrent Deferred Tax Liabilities [Member]        
Income Tax Contingency [Line Items]        
Unrecognized tax benefits 5 3,000    
Other Taxes Payable [Member]        
Income Tax Contingency [Line Items]        
Unrecognized tax benefits $ 3,000 $ 2,500    
[1] In 2021, included in Income taxes payable ($19 million), Other current assets ($42 million) Noncurrent deferred tax assets and other noncurrent tax assets ($3.0 billion), Noncurrent deferred tax liabilities ($5 million) and Other taxes payable ($3.0 billion). In 2020, included in Income taxes payable ($34 million), Noncurrent deferred tax assets and other noncurrent tax assets ($18 million), Noncurrent deferred tax liabilities ($3.0 billion) and Other taxes payable ($2.5 billion).
v3.22.0.1
Tax Matters - Taxes on Items of Other Comprehensive Income/(Loss) (Details) - USD ($)
$ in Millions
 12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Tax Expense/(Benefit) on Other Comprehensive Income/(Loss)      
Foreign currency translation adjustments, net [1] $ 43 $ (119) $ 260
Unrealized holding gains/(losses) on derivative financial instruments, net 84 (88) 83
Reclassification adjustments for (gains)/losses included in net income 29 (25) (125)
Other comprehensive income (loss), derivatives qualifying as hedges, tax, total 114 (113) (42)
Unrealized holding gains/(losses) on available-for-sale securities, net (44) 45  
Reclassification adjustments for (gains)/losses included in net income (4) (24) 5
Other comprehensive income (loss), available-for-sale securities, tax, total (48) 22 5
Benefit plans: prior service (costs)/credits and other, net 27 12 (1)
Reclassification adjustments related to amortization of prior service costs and other, net (47) (31) (43)
Reclassification adjustments related to curtailments of prior service costs and other, net (17) 0 (1)
Other (1) 1 0
Other comprehensive income (loss), pension and other postretirement benefit plans, net prior service cost (credit), tax (38) (17) (45)
Tax provision/(benefit) on other comprehensive income/(loss) $ 71 $ (227) $ 178
[1] Taxes are not provided for foreign currency translation adjustments relating to investments in international subsidiaries that are expected to be held indefinitely.
v3.22.0.1
Accumulated Other Comprehensive Loss, Excluding Noncontrolling Interests (Details) - USD ($)
$ in Millions
 12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Accumulated Other Comprehensive Income (Loss) [Roll Forward]      
Beginning balance $ 63,473 $ 63,447 $ 63,758
Other comprehensive income/(loss) (589) 471 (130)
Distribution of Upjohn Business [1]   (2,018)  
Ending balance 77,462 63,473 63,447
Accumulated Other Comprehensive Income/(Loss) [Member]      
Accumulated Other Comprehensive Income (Loss) [Roll Forward]      
Beginning balance [2] (5,310) (5,367) (5,249)
Other comprehensive income/(loss) [2],[3] (587) 480 (118)
Distribution of Upjohn Business [1],[2],[4]   (423)  
Ending balance [2] (5,897) (5,310) (5,367)
Foreign Currency Translation Adjustments [Member]      
Accumulated Other Comprehensive Income (Loss) [Roll Forward]      
Beginning balance [2] (5,450) (5,936) (6,075)
Other comprehensive income/(loss) [2],[3] (722) 883 139
Distribution of Upjohn Business [2],[4]   (397)  
Ending balance [2] (6,172) (5,450) (5,936)
Derivative Financial Instruments [Member]      
Accumulated Other Comprehensive Income (Loss) [Roll Forward]      
Beginning balance [2] (428) 20 167
Other comprehensive income/(loss) [2],[3] 547 (448) (146)
Distribution of Upjohn Business [2],[4]   0  
Ending balance [2] 119 (428) 20
Available-For-Sale Securities [Member]      
Accumulated Other Comprehensive Income (Loss) [Roll Forward]      
Beginning balance [2] 116 (35) (68)
Other comprehensive income/(loss) [2],[3] (336) 151 33
Distribution of Upjohn Business [2],[4]   0  
Ending balance [2] (220) 116 (35)
Prior Service (Costs)/Credits and Other [Member]      
Accumulated Other Comprehensive Income (Loss) [Roll Forward]      
Beginning balance [2] 452 584 728
Other comprehensive income/(loss) [2],[3] (75) (106) (144)
Distribution of Upjohn Business [2],[4]   (26)  
Ending balance [2] $ 377 $ 452 $ 584
[1] See Note 2B.
[2] Amounts include the impact of a change in accounting principle. See Note 1C.
[3] Amounts do not include foreign currency translation adjustments attributable to noncontrolling interests. Foreign currency translation adjustments include net losses in 2021 and net gains in 2020 and 2019 related to our equity-method investment in the Consumer Healthcare JV (see Note 2C), and the impact of our net investment hedging program.
[4] For more information, see Note 2B.
v3.22.0.1
Financial Instruments - Financial Assets and Liabilities Measured at Fair Value on a Recurring Basis (Details) - USD ($)
$ in Millions
Dec. 31, 2021
Dec. 31, 2020
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]    
Equity securities [1] $ 5,365 $ 567
Total other noncurrent assets 7,679 4,879
Total assets 181,476 154,229
Total liabilities 881 1,100
Recurring [Member]    
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]    
Total assets 33,552 14,278
Government and agency debt - non-U.S. [Member]    
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]    
Available-for-sale securities, debt securities 17,783 7,725
Government and agency - U.S. [Member]    
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]    
Available-for-sale securities, debt securities 4,055 1,103
Corporate and Other [Member]    
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]    
Available-for-sale securities, debt securities 697 1,008
Level 1 [Member] | Recurring [Member]    
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]    
Total assets 3,849 2,776
Level 2 [Member] | Recurring [Member]    
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]    
Total assets 29,703 11,501
Short-term Investments [Member] | Recurring [Member]    
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]    
Available-for-sale securities, debt securities 22,014 9,709
Total short-term investments 27,379 10,276
Short-term Investments [Member] | Money market funds [Member] | Recurring [Member]    
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]    
Equity securities 5,365 567
Short-term Investments [Member] | Government and agency debt - non-U.S. [Member] | Recurring [Member]    
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]    
Available-for-sale securities, debt securities 17,318 7,719
Short-term Investments [Member] | Government and agency - U.S. [Member] | Recurring [Member]    
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]    
Available-for-sale securities, debt securities 4,050 982
Short-term Investments [Member] | Corporate and Other [Member] | Recurring [Member]    
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]    
Available-for-sale securities, debt securities 647 1,008
Short-term Investments [Member] | Level 1 [Member] | Recurring [Member]    
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]    
Available-for-sale securities, debt securities 0 0
Total short-term investments 0 0
Short-term Investments [Member] | Level 1 [Member] | Money market funds [Member] | Recurring [Member]    
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]    
Equity securities 0 0
Short-term Investments [Member] | Level 1 [Member] | Government and agency debt - non-U.S. [Member] | Recurring [Member]    
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]    
Available-for-sale securities, debt securities 0 0
Short-term Investments [Member] | Level 1 [Member] | Government and agency - U.S. [Member] | Recurring [Member]    
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]    
Available-for-sale securities, debt securities 0 0
Short-term Investments [Member] | Level 1 [Member] | Corporate and Other [Member] | Recurring [Member]    
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]    
Available-for-sale securities, debt securities 0 0
Short-term Investments [Member] | Level 2 [Member] | Recurring [Member]    
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]    
Available-for-sale securities, debt securities 22,014 9,709
Total short-term investments 27,379 10,276
Short-term Investments [Member] | Level 2 [Member] | Money market funds [Member] | Recurring [Member]    
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]    
Equity securities 5,365 567
Short-term Investments [Member] | Level 2 [Member] | Government and agency debt - non-U.S. [Member] | Recurring [Member]    
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]    
Available-for-sale securities, debt securities 17,318 7,719
Short-term Investments [Member] | Level 2 [Member] | Government and agency - U.S. [Member] | Recurring [Member]    
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]    
Available-for-sale securities, debt securities 4,050 982
Short-term Investments [Member] | Level 2 [Member] | Corporate and Other [Member] | Recurring [Member]    
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]    
Available-for-sale securities, debt securities 647 1,008
Other Current Assets [Member] | Recurring [Member]    
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]    
Current derivative assets 709 251
Other Current Assets [Member] | Recurring [Member] | Interest rate contracts [Member]    
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]    
Current derivative assets 4 18
Other Current Assets [Member] | Recurring [Member] | Foreign exchange contracts [Member]    
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]    
Current derivative assets 704 234
Other Current Assets [Member] | Level 1 [Member] | Recurring [Member]    
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]    
Current derivative assets 0 0
Other Current Assets [Member] | Level 1 [Member] | Recurring [Member] | Interest rate contracts [Member]    
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]    
Current derivative assets 0 0
Other Current Assets [Member] | Level 1 [Member] | Recurring [Member] | Foreign exchange contracts [Member]    
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]    
Current derivative assets 0 0
Other Current Assets [Member] | Level 2 [Member] | Recurring [Member]    
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]    
Current derivative assets 709 251
Other Current Assets [Member] | Level 2 [Member] | Recurring [Member] | Interest rate contracts [Member]    
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]    
Current derivative assets 4 18
Other Current Assets [Member] | Level 2 [Member] | Recurring [Member] | Foreign exchange contracts [Member]    
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]    
Current derivative assets 704 234
Long-term Investments [Member] | Recurring [Member]    
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]    
Equity securities [2] 3,876 2,809
Available-for-sale securities, debt securities 521 128
Total long-term investments 4,397 2,936
Long-term Investments [Member] | Government and agency debt - non-U.S. [Member] | Recurring [Member]    
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]    
Available-for-sale securities, debt securities 465 6
Long-term Investments [Member] | Government and agency - U.S. [Member] | Recurring [Member]    
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]    
Available-for-sale securities, debt securities 6 121
Long-term Investments [Member] | Corporate and Other [Member] | Recurring [Member]    
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]    
Available-for-sale securities, debt securities 50 0
Long-term Investments [Member] | Level 1 [Member] | Recurring [Member]    
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]    
Equity securities [2] 3,849 2,776
Available-for-sale securities, debt securities 0 0
Total long-term investments 3,849 2,776
Long-term Investments [Member] | Level 1 [Member] | Government and agency debt - non-U.S. [Member] | Recurring [Member]    
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]    
Available-for-sale securities, debt securities 0 0
Long-term Investments [Member] | Level 1 [Member] | Government and agency - U.S. [Member] | Recurring [Member]    
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]    
Available-for-sale securities, debt securities 0 0
Long-term Investments [Member] | Level 1 [Member] | Corporate and Other [Member] | Recurring [Member]    
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]    
Available-for-sale securities, debt securities 0 0
Long-term Investments [Member] | Level 2 [Member] | Recurring [Member]    
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]    
Equity securities [2] 27 32
Available-for-sale securities, debt securities 521 128
Total long-term investments 548 160
Long-term Investments [Member] | Level 2 [Member] | Government and agency debt - non-U.S. [Member] | Recurring [Member]    
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]    
Available-for-sale securities, debt securities 465 6
Long-term Investments [Member] | Level 2 [Member] | Government and agency - U.S. [Member] | Recurring [Member]    
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]    
Available-for-sale securities, debt securities 6 121
Long-term Investments [Member] | Level 2 [Member] | Corporate and Other [Member] | Recurring [Member]    
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]    
Available-for-sale securities, debt securities 50 0
Other Noncurrent Assets [Member] | Recurring [Member]    
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]    
Noncurrent derivative assets 259 122
Insurance contracts [3] 808 693
Total other noncurrent assets 1,067 814
Other Noncurrent Assets [Member] | Recurring [Member] | Interest rate contracts [Member]    
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]    
Noncurrent derivative assets 16 117
Other Noncurrent Assets [Member] | Recurring [Member] | Foreign exchange contracts [Member]    
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]    
Noncurrent derivative assets 242 5
Other Noncurrent Assets [Member] | Level 1 [Member] | Recurring [Member]    
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]    
Noncurrent derivative assets 0 0
Insurance contracts [3] 0 0
Total other noncurrent assets 0 0
Other Noncurrent Assets [Member] | Level 1 [Member] | Recurring [Member] | Interest rate contracts [Member]    
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]    
Noncurrent derivative assets 0 0
Other Noncurrent Assets [Member] | Level 1 [Member] | Recurring [Member] | Foreign exchange contracts [Member]    
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]    
Noncurrent derivative assets 0 0
Other Noncurrent Assets [Member] | Level 2 [Member] | Recurring [Member]    
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]    
Noncurrent derivative assets 259 122
Insurance contracts [3] 808 693
Total other noncurrent assets 1,067 814
Other Noncurrent Assets [Member] | Level 2 [Member] | Recurring [Member] | Interest rate contracts [Member]    
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]    
Noncurrent derivative assets 16 117
Other Noncurrent Assets [Member] | Level 2 [Member] | Recurring [Member] | Foreign exchange contracts [Member]    
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]    
Noncurrent derivative assets 242 5
Other Current Liabilities [Member] | Recurring [Member]    
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]    
Current derivative liabilities 476 501
Other Current Liabilities [Member] | Recurring [Member] | Foreign exchange contracts [Member]    
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]    
Current derivative liabilities 476 501
Other Current Liabilities [Member] | Level 1 [Member] | Recurring [Member]    
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]    
Current derivative liabilities 0 0
Other Current Liabilities [Member] | Level 1 [Member] | Recurring [Member] | Foreign exchange contracts [Member]    
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]    
Current derivative liabilities 0 0
Other Current Liabilities [Member] | Level 2 [Member] | Recurring [Member]    
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]    
Current derivative liabilities 476 501
Other Current Liabilities [Member] | Level 2 [Member] | Recurring [Member] | Foreign exchange contracts [Member]    
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]    
Current derivative liabilities 476 501
Other Noncurrent Liabilities [Member] | Recurring [Member]    
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]    
Noncurrent derivative liabilities 405 599
Total liabilities   1,100
Other Noncurrent Liabilities [Member] | Recurring [Member] | Foreign exchange contracts [Member]    
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]    
Noncurrent derivative liabilities 405 599
Other Noncurrent Liabilities [Member] | Level 1 [Member] | Recurring [Member]    
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]    
Noncurrent derivative liabilities 0 0
Total liabilities 0 0
Other Noncurrent Liabilities [Member] | Level 1 [Member] | Recurring [Member] | Foreign exchange contracts [Member]    
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]    
Noncurrent derivative liabilities 0 0
Other Noncurrent Liabilities [Member] | Level 2 [Member] | Recurring [Member]    
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]    
Noncurrent derivative liabilities 405 599
Total liabilities 881 1,100
Other Noncurrent Liabilities [Member] | Level 2 [Member] | Recurring [Member] | Foreign exchange contracts [Member]    
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]    
Noncurrent derivative liabilities $ 405 $ 599
[1] As of December 31, 2021 and 2020, includes money market funds primarily invested in U.S. Treasury and government debt.
[2] Long-term equity securities of $194 million as of December 31, 2021 and $190 million as of December 31, 2020 were held in restricted trusts for U.S. non-qualified employee benefit plans.
[3] Includes life insurance policies held in restricted trusts for U.S. non-qualified employee benefit plans. The underlying invested assets in these contracts are marketable securities, which are carried at fair value, with changes in fair value recognized in Other (income)/deductions—net (see Note 4).
v3.22.0.1
Financial Instruments - Financial Assets and Liabilities Measured at Fair Value on a Recurring Basis - Footnotes (Details) - USD ($)
$ in Millions
Dec. 31, 2021
Dec. 31, 2020
Recurring [Member]    
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]    
Long-term equity securities held in trust $ 194 $ 190
v3.22.0.1
Financial Instruments - Assets and Liabilities Not Measured at Fair Value on a Recurring Basis (Details) - USD ($)
$ in Millions
Dec. 31, 2021
Dec. 31, 2020
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]    
Long-term debt $ 36,195 $ 37,133
Level 2 [Member] | Estimated Fair Value [Member]    
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]    
Long-term debt, excluding the current portion $ 42,000 $ 46,000
v3.22.0.1
Financial Instruments - Investments - Short-term, Long-term and Equity Method Investments (Details) - USD ($)
$ in Millions
Dec. 31, 2021
Dec. 31, 2020
Short-term investments    
Equity securities with readily determinable fair values [1] $ 5,365 $ 567
Available-for-sale debt securities 22,014 9,709
Held-to-maturity debt securities 1,746 161
Total Short-term investments 29,125 10,437
Long-term investments    
Equity securities with readily determinable fair values 3,876 2,809
Available-for-sale debt securities 521 128
Held-to-maturity debt securities 34 37
Private equity securities at cost [2] 623 432
Long-term investments 5,054 3,406
Equity-method investments 16,472 16,856
Total long-term investments and equity-method investments 21,526 20,262
Held-to-maturity cash equivalents $ 268 $ 89
[1] As of December 31, 2021 and 2020, includes money market funds primarily invested in U.S. Treasury and government debt.
[2] Represent investments in the life sciences sector.
v3.22.0.1
Financial Instruments - Investments - Debt Securities (Details) - USD ($)
$ in Millions
Dec. 31, 2021
Dec. 31, 2020
Debt Securities, Held-to-maturity, Maturity, Fair Value [Abstract]    
Debt securities, amortized cost $ 24,835 $ 9,991
Debt securities, gross unrealized gains 14 138
Debt securities, gross unrealized losses (265) (5)
Debt securities, fair value 24,584 10,124
Debt securities maturities, within 1 year, fair value 24,029  
Debt securities maturities, over 1 to 5 years, fair value 543  
Debt securities maturities, over 5 years, fair value 13  
Government and agency debt - non-U.S. [Member]    
Debt Securities, Available-for-sale, Fair Value to Amortized Cost [Abstract]    
Available-for-sale debt securities, amortized cost 18,032 7,593
Available-for-sale debt securities, gross unrealized gain 13 136
Available-for-sale debt securities, gross unrealized loss (263) (4)
Available-for-sale securities, debt maturities 17,783 7,725
Available-for-sale Securities, Debt Maturities [Abstract]    
Available-for-sale securities, debt maturities, within 1 year, fair value 17,318  
Available-for-sale securities, debt maturities, over 1 to 5 years, fair value 465  
Available-for-sale securities, debt maturities, over 5 years, fair value 0  
Available-for-sale securities, debt maturities 17,783 7,725
Debt Securities, Held-to-maturity, Maturity [Abstract]    
Held-to-maturity securities, amortized cost 1,102 5
Held-to-maturity securities, gross unrealized gains 0 0
Held-to-maturity securities, gross unrealized losses 0 0
Held-to-maturity securities, fair value 1,102 5
Debt Securities, Held-to-maturity, Maturity, Fair Value [Abstract]    
Held-to-maturity securities, debt maturities, within 1 year, fair value 1,097  
Held-to-maturity securities, debt maturities, over 1 to 5 years, fair value 4  
Held-to-maturity securities, debt maturities, over 5 years, fair value 1  
Government and agency - U.S. [Member]    
Debt Securities, Available-for-sale, Fair Value to Amortized Cost [Abstract]    
Available-for-sale debt securities, amortized cost 4,056 1,104
Available-for-sale debt securities, gross unrealized gain 0 0
Available-for-sale debt securities, gross unrealized loss (1) (1)
Available-for-sale securities, debt maturities 4,055 1,103
Available-for-sale Securities, Debt Maturities [Abstract]    
Available-for-sale securities, debt maturities, within 1 year, fair value 4,050  
Available-for-sale securities, debt maturities, over 1 to 5 years, fair value 6  
Available-for-sale securities, debt maturities, over 5 years, fair value 0  
Available-for-sale securities, debt maturities 4,055 1,103
Corporate and Other [Member]    
Debt Securities, Available-for-sale, Fair Value to Amortized Cost [Abstract]    
Available-for-sale debt securities, amortized cost 698 1,006
Available-for-sale debt securities, gross unrealized gain 0 2
Available-for-sale debt securities, gross unrealized loss (1) 0
Available-for-sale securities, debt maturities 697 1,008
Available-for-sale Securities, Debt Maturities [Abstract]    
Available-for-sale securities, debt maturities, within 1 year, fair value 647  
Available-for-sale securities, debt maturities, over 1 to 5 years, fair value 50  
Available-for-sale securities, debt maturities, over 5 years, fair value 0  
Available-for-sale securities, debt maturities 697 1,008
Time deposits and other [Member]    
Debt Securities, Held-to-maturity, Maturity [Abstract]    
Held-to-maturity securities, amortized cost 947 283
Held-to-maturity securities, gross unrealized gains 0 0
Held-to-maturity securities, gross unrealized losses 0 0
Held-to-maturity securities, fair value 947 $ 283
Debt Securities, Held-to-maturity, Maturity, Fair Value [Abstract]    
Held-to-maturity securities, debt maturities, within 1 year, fair value 917  
Held-to-maturity securities, debt maturities, over 1 to 5 years, fair value 18  
Held-to-maturity securities, debt maturities, over 5 years, fair value $ 11  
v3.22.0.1
Financial Instruments - Investments - Unrealized Gains and Losses Related to Equity Securities (Details) - USD ($)
$ in Millions
 12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Financial Instruments [Abstract]      
Net (gains)/losses recognized during the period on investments in equity securities [1],[2] $ (1,344) $ (540) $ (454)
Less: Net (gains)/losses recognized during the period on equity securities sold during the period (80) (24) (25)
Net unrealized (gains)/losses during the reporting period on equity securities still held at the reporting date [3] $ (1,264) $ (515) $ (429)
[1] Reported in Other (income)/deductions––net. See Note 4.
[2] (b)2021 gains include, among other things, unrealized gains of $1.6 billion related to investments in BioNTech and Cerevel. 2020 gains included, among other things, unrealized gains of $405 million related to investments in BioNTech and SpringWorks Therapeutics, Inc. (SpringWorks). 2019 gains included, among other things, unrealized gains of $295 million related to investments in Cortexyme, Inc. and SpringWorks.
[3] Included in net unrealized gains are observable price changes on equity securities without readily determinable fair values. As of December 31, 2021, there were cumulative impairments and downward adjustments of $97 million and upward adjustments of $156 million. Impairments, downward and upward adjustments were not significant in 2021, 2020 and 2019
v3.22.0.1
Financial Instruments - Investments - Unrealized Gains and Losses Related to Equity Securities - Footnotes (Details)
$ in Millions
Dec. 31, 2021
USD ($)
Financial Instruments [Abstract]  
Cumulative impairment losses and downward price adjustments on equity securities $ 97
Cumulative upward price adjustments on equity securities $ 156
v3.22.0.1
Financial Instruments - Short-Term Borrowings (Details) - USD ($)
Dec. 31, 2021
Dec. 31, 2020
Jun. 30, 2020
Short-term Debt [Line Items]      
Commercial paper $ 0 $ 556,000,000  
Current portion of long-term debt, principal amount 1,636,000,000 2,004,000,000  
Other short-term borrowings [1] 605,000,000 145,000,000  
Total short-term borrowings, principal amount 2,241,000,000 2,705,000,000  
Net unamortized discounts, premiums and debt issuance costs 0 (2,000,000)  
Total Short-term borrowings, including current portion of long-term debt, carried at historical proceeds, as adjusted 2,241,000,000 $ 2,703,000,000  
Commercial Paper [Member]      
Short-term Debt [Line Items]      
Commercial paper, weighted average interest rate   0.13%  
Line of Credit [Member]      
Short-term Debt [Line Items]      
Line of credit facility, maximum borrowing capacity 360,000,000    
Line of credit facility, due to expire within one year 322,000,000    
Line of Credit [Member] | Commercial Paper [Member]      
Short-term Debt [Line Items]      
Line of credit facility, maximum borrowing capacity     $ 4,000,000,000
Credit Facility Expiring 2025 [Member] | Line of Credit [Member] | Commercial Paper [Member]      
Short-term Debt [Line Items]      
Line of credit facility, maximum borrowing capacity $ 7,000,000,000    
[1] Primarily includes cash collateral. See Note 7F.
v3.22.0.1
Financial Instruments - Long-Term Debt (Details) - USD ($)
$ in Millions
Dec. 31, 2021
Dec. 31, 2020
Debt Instrument [Line Items]    
Net unamortized discounts, premiums and debt issuance costs $ 0 $ (2)
Total long-term debt, carried at historical proceeds, as adjusted 36,195 37,133
Current portion of long-term debt, carried at historical proceeds, as adjusted (not included above (1.0% for 2021 and 2.6% for 2020)) $ 1,636 $ 2,002
Unsecured Debt [Member]    
Debt Instrument [Line Items]    
Interest rate, percentage 1.00% 2.60%
Total principal amount of long-term debt $ 34,948 $ 35,774
Net fair value adjustments related to hedging and purchase accounting 1,438 1,562
Net unamortized discounts, premiums and debt issuance costs (195) (207)
Other long-term debt 4 4
Total long-term debt, carried at historical proceeds, as adjusted 36,195 37,133
Current portion of long-term debt, carried at historical proceeds, as adjusted (not included above (1.0% for 2021 and 2.6% for 2020)) 1,636 $ 2,002
Unsecured Debt [Member] | Senior Unsecured Debt, Due 2022 [Member]    
Debt Instrument [Line Items]    
Interest rate, percentage   1.00%
Total principal amount of long-term debt [1] $ 0 $ 1,728
Unsecured Debt [Member] | Senior Unsecured Debt, Due 2023 [Member]    
Debt Instrument [Line Items]    
Interest rate, percentage 3.20% 3.20%
Total principal amount of long-term debt $ 2,550 $ 2,550
Unsecured Debt [Member] | Senior Unsecured Debt, Due 2024 [Member]    
Debt Instrument [Line Items]    
Interest rate, percentage 3.90% 3.90%
Total principal amount of long-term debt $ 2,250 $ 2,250
Unsecured Debt [Member] | Senior Unsecured Debt, Due 2025 [Member]    
Debt Instrument [Line Items]    
Interest rate, percentage 0.80% 0.80%
Total principal amount of long-term debt $ 750 $ 750
Unsecured Debt [Member] | Senior Unsecured Debt, Due 2026 [Member]    
Debt Instrument [Line Items]    
Interest rate, percentage 2.90% 2.90%
Total principal amount of long-term debt $ 3,000 $ 3,000
Unsecured Debt [Member] | Senior Unsecured Debt, Due 2027 [Member]    
Debt Instrument [Line Items]    
Interest rate, percentage 2.10% 2.00%
Total principal amount of long-term debt $ 1,051 $ 1,121
Unsecured Debt [Member] | Senior Unsecured Debt, Due 2028-2032 [Member]    
Debt Instrument [Line Items]    
Interest rate, percentage 3.10% 3.40%
Total principal amount of long-term debt $ 6,660 $ 5,660
Unsecured Debt [Member] | Senior Unsecured Debt, Due 2033-2037 [Member]    
Debt Instrument [Line Items]    
Interest rate, percentage 5.60% 5.60%
Total principal amount of long-term debt $ 4,250 $ 4,250
Unsecured Debt [Member] | Senior Unsecured Debt, Due 2038-2042 [Member]    
Debt Instrument [Line Items]    
Interest rate, percentage 5.50% 5.50%
Total principal amount of long-term debt $ 6,079 $ 6,086
Unsecured Debt [Member] | Senior Unsecured Debt, Due 2043-2047 [Member]    
Debt Instrument [Line Items]    
Interest rate, percentage 3.70% 3.70%
Total principal amount of long-term debt $ 4,858 $ 4,878
Unsecured Debt [Member] | Senior Unsecured Debt, Due 2048-2050 [Member]    
Debt Instrument [Line Items]    
Interest rate, percentage 3.60% 3.60%
Total principal amount of long-term debt $ 3,500 $ 3,500
[1] Reclassified to the current portion of long-term debt.
v3.22.0.1
Financial Instruments - Long-Term Debt, New Issuances (Details) - Senior Notes [Member] - Senior Unsecured Debt, One Point Seven Five Zero Percent, Due August 2031
$ in Millions
Dec. 31, 2021
USD ($)
Debt Instrument [Line Items]  
Effective interest rate 1.79%
Stated interest rate 1.75% [1]
Principal amount $ 1,000 [1]
[1] The notes may be redeemed by us at any time, in whole, or in part, at a redemption price plus accrued and unpaid interest.
v3.22.0.1
Financial Instruments - Long-Term Debt, Narrative (Details)
$ in Millions, € in Billions
 1 Months Ended 12 Months Ended
Nov. 30, 2020
USD ($)
Jan. 31, 2019
USD ($)
Dec. 31, 2019
USD ($)
Dec. 31, 2021
Dec. 31, 2020
May 31, 2020
USD ($)
Mar. 31, 2020
USD ($)
Mar. 31, 2019
USD ($)
Jan. 31, 2019
EUR (€)
Debt Instrument [Line Items]                  
Loss on early retirement of debt     $ 138            
Senior Unsecured Euro Debt, 5.75%, Due 2021 [Member]                  
Debt Instrument [Line Items]                  
Loss on early retirement of debt   $ 138              
Senior Notes [Member]                  
Debt Instrument [Line Items]                  
Debt instrument, face amount           $ 4,000 $ 1,250 $ 5,000  
Weighted average interest rate           2.11% 2.67% 3.57%  
Loss on early retirement of debt $ 36                
Senior Notes [Member] | Senior Unsecured Debt, One Point Nine Five Percent, Due 2021 [Member]                  
Debt Instrument [Line Items]                  
Repurchased debt $ 1,150                
Stated interest rate 1.95%                
Senior Notes [Member] | Senior Unsecured Debt, Five Point Eight Zero Percent, Due 2023 [Member]                  
Debt Instrument [Line Items]                  
Repurchased debt $ 342                
Stated interest rate 5.80%                
Senior Notes [Member] | Senior Unsecured Euro Debt, 5.75%, Due 2021 [Member]                  
Debt Instrument [Line Items]                  
Repurchased debt   $ 1,300             € 1.1
Stated interest rate   5.75%             5.75%
Redemption value   $ 1,500             € 1.3
Unsecured Debt [Member]                  
Debt Instrument [Line Items]                  
Weighted average interest rate       1.00% 2.60%        
Unsecured Debt [Member] | Senior Notes Due 2047 [Member]                  
Debt Instrument [Line Items]                  
Repurchased debt             $ 1,065    
v3.22.0.1
Financial Instruments - Derivative Financial Instruments and Hedging Activities- Narrative (Details)
 12 Months Ended
Dec. 31, 2021
Foreign Exchange Contract [Member]  
Derivative [Line Items]  
Derivative term of contract 2 years
v3.22.0.1
Financial Instruments - Fair Value of Derivative Financial Instruments and Related Notional Amounts (Details) - USD ($)
$ in Millions
Dec. 31, 2021
Dec. 31, 2020
Derivative [Line Items]    
Derivative asset $ 968 $ 373
Derivative liability 881 1,100
Designated as Hedging Instrument [Member]    
Derivative [Line Items]    
Derivative asset 808 280
Derivative liability 717 1,005
Foreign exchange contracts [Member] | Designated as Hedging Instrument [Member]    
Derivative [Line Items]    
Derivative, notional amount [1] 29,576 24,369
Derivative asset [1] 787 145
Derivative liability [1] 717 1,005
Foreign exchange contracts [Member] | Not Designated as Hedging Instrument [Member]    
Derivative [Line Items]    
Derivative, notional amount 21,419 15,063
Derivative asset 160 94
Derivative liability 164 95
Interest rate contracts [Member] | Designated as Hedging Instrument [Member]    
Derivative [Line Items]    
Derivative, notional amount 2,250 1,950
Derivative asset 21 135
Derivative liability 0 0
Sales [Member] | Foreign exchange contracts [Member] | Designated as Hedging Instrument [Member]    
Derivative [Line Items]    
Derivative, notional amount $ 4,800 $ 5,000
[1] The notional amount of outstanding foreign exchange contracts hedging our intercompany forecasted inventory sales was $4.8 billion as of December 31, 2021 and $5.0 billion as of December 31, 2020.
v3.22.0.1
Financial Instruments - Derivative Financial Instruments and Hedging Activities (Details) - USD ($)
$ in Millions
 12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Derivative Instruments, Gain (Loss) [Line Items]      
Amount of Gains/(Losses) Recognized in OCI $ 526 $ (582) $ 476
Amount of Gains/(Losses) Recognized in OCI [1],[2] 1 12  
Amount of Gains/(Losses) Recognized in OCI [1] 1,210 (1,077)  
Amount of Gains/(Losses) Reclassified from OCI into OID and COS [3] (134) (21) $ 664
Other Nonoperating Income (Expense) [Member]      
Derivative Instruments, Gain (Loss) [Line Items]      
Amount of Gains/(Losses) Recognized in OID [1] (192) 178  
Other (Income) Deductions And Cost Of Sales [Member]      
Derivative Instruments, Gain (Loss) [Line Items]      
Amount of Gains/(Losses) Reclassified from OCI into OID and COS [1],[2] 1 (1)  
Amount of Gains/(Losses) Reclassified from OCI into OID and COS [1] (25) 133  
Designated as Hedging Instrument [Member] | Foreign exchange contracts [Member]      
Derivative Instruments, Gain (Loss) [Line Items]      
Amount of Gains/(Losses) Recognized in OCI [1],[4] 488 (649)  
Amount of Gains/(Losses) Recognized in OCI [1] 468 (501)  
Amount of Gains/(Losses) Reclassified from OCI into OID and COS (89) [1] 172  
Designated as Hedging Instrument [Member] | Foreign exchange contracts [Member] | Other (Income) Deductions And Cost Of Sales [Member]      
Derivative Instruments, Gain (Loss) [Line Items]      
Amount of Gains/(Losses) Reclassified from OCI into OID and COS [1],[4] (173) (77)  
Amount of Gains/(Losses) Reclassified from OCI into OID and COS [1] 0    
Designated as Hedging Instrument [Member] | Interest rate contracts [Member] | Other Nonoperating Income (Expense) [Member]      
Derivative Instruments, Gain (Loss) [Line Items]      
Amount of Gains/(Losses) Recognized in OID [1] (7) 369  
Hedged Item [1] 7 (369)  
Designated as Hedging Instrument [Member] | Foreign currency short-term borrowings [Member]      
Derivative Instruments, Gain (Loss) [Line Items]      
Amount of Gains/(Losses) Recognized in OCI [1] 78 8  
Designated as Hedging Instrument [Member] | Foreign currency short-term borrowings [Member] | Other (Income) Deductions And Cost Of Sales [Member]      
Derivative Instruments, Gain (Loss) [Line Items]      
Amount of Gain/(Losses) Reclassified from OCI into OID and COS [1] 0    
Designated as Hedging Instrument [Member] | Foreign currency long-term debt [Member]      
Derivative Instruments, Gain (Loss) [Line Items]      
Amount of Gains/(Losses) Recognized in OCI [1],[5] 86 (183)  
Designated as Hedging Instrument [Member] | Foreign currency long-term debt [Member] | Other (Income) Deductions And Cost Of Sales [Member]      
Derivative Instruments, Gain (Loss) [Line Items]      
Amount of Gain/(Losses) Reclassified from OCI into OID and COS [1],[5] 0    
Designated as Hedging Instrument [Member] | Cash Flow Hedging [Member] | Foreign exchange contracts [Member]      
Derivative Instruments, Gain (Loss) [Line Items]      
Amount excluded from effectiveness testing and amortized into earnings [1],[2] 38 55  
Designated as Hedging Instrument [Member] | Cash Flow Hedging [Member] | Foreign exchange contracts [Member] | Other (Income) Deductions And Cost Of Sales [Member]      
Derivative Instruments, Gain (Loss) [Line Items]      
Amount excluded from effectiveness testing [1],[2] 38 57  
Designated as Hedging Instrument [Member] | Net Investment Hedging [Member] | Foreign exchange contracts [Member]      
Derivative Instruments, Gain (Loss) [Line Items]      
Amount excluded from effectiveness testing and amortized into earnings [1],[2] 52 181  
Designated as Hedging Instrument [Member] | Net Investment Hedging [Member] | Foreign exchange contracts [Member] | Other (Income) Deductions And Cost Of Sales [Member]      
Derivative Instruments, Gain (Loss) [Line Items]      
Amount excluded from effectiveness testing [1],[2] 109 154  
Not Designated as Hedging Instrument [Member] | Foreign exchange contracts [Member] | Other Nonoperating Income (Expense) [Member]      
Derivative Instruments, Gain (Loss) [Line Items]      
Amount of Gains/(Losses) Recognized in OID [1] $ (192) $ 178  
[1] OID = Other (income)/deductions—net, included in Other (income)/deductions—net in the consolidated statements of income. COS = Cost of Sales, included in Cost of sales in the consolidated statements of income. OCI = Other comprehensive income/(loss), included in the consolidated statements of comprehensive income.
[2] The amounts reclassified from OCI were reclassified into OID.
[3] Reclassified into Other (income)/deductions—net and Cost of sales. See Note 7E.
[4] The amounts reclassified from OCI into COS were:
•a net loss of $89 million in 2021; and
•a net gain of $172 million in 2020 (including a gain of $22 million reported in Discontinued operations––net of tax).
The remaining amounts were reclassified from OCI into OID. Based on year-end foreign exchange rates that are subject to change, we expect to reclassify a pre-tax gain of $362 million within the next 12 months into income. The maximum length of time over which we are hedging our exposure to the variability in future foreign exchange cash flows is approximately 21 years and relates to foreign currency debt.
[5] Short-term borrowings and long-term debt include foreign currency borrowings which are used as net investment hedges. The short-term borrowings carrying value as of December 31, 2021 was $1.1 billion. The long-term debt carrying values as of December 31, 2021 and December 31, 2020 were $844 million and $2.1 billion, respectively.
v3.22.0.1
Financial Instruments - Derivative Financial Instruments and Hedging Activities - Footnotes (Details) - USD ($)
$ in Millions
 12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Derivative [Line Items]      
Gain (loss) reclassified from OCI into OID and COS [1] $ (134) $ (21) $ 664
Amount of pre-tax loss to be reclassified (362)    
Carrying value of short-term borrowings 2,241 2,703  
Foreign Currency Debt [Member]      
Derivative [Line Items]      
Carrying value of short-term borrowings 1,100    
Principal amount 844 2,100  
Designated as Hedging Instrument [Member] | Foreign Exchange Contract [Member]      
Derivative [Line Items]      
Gain (loss) reclassified from OCI into OID and COS $ (89) [2] 172  
Remaining period of hedging exposure 21 years    
Designated as Hedging Instrument [Member] | Foreign Exchange Contract [Member] | Discontinued Operations [Member]      
Derivative [Line Items]      
Gain (loss) reclassified from OCI into OID and COS   $ 22  
[1] Reclassified into Other (income)/deductions—net and Cost of sales. See Note 7E.
[2] OID = Other (income)/deductions—net, included in Other (income)/deductions—net in the consolidated statements of income. COS = Cost of Sales, included in Cost of sales in the consolidated statements of income. OCI = Other comprehensive income/(loss), included in the consolidated statements of comprehensive income.
v3.22.0.1
Financial Instruments - Cumulative Basis Adjustments for Fair Value Hedges (Details) - Long-term debt [Member] - USD ($)
$ in Millions
Dec. 31, 2021
Dec. 31, 2020
Derivative [Line Items]    
Carrying Amount of Hedged Assets Liabilities [1] $ 2,233 $ 2,016
Cumulative Amount of Fair Value Hedging Adjustment Increase/(Decrease) to Carrying Amount, Active Hedging Relationships, Liability 16 117
Cumulative Amount of Fair Value Hedging Adjustment Increase/(Decrease) to Carrying Amount, Discontinued Hedging Relationships, Liability $ 1,154 $ 1,149
[1] Carrying amounts exclude the cumulative amount of fair value hedging adjustments.
v3.22.0.1
Financial Instruments - Credit Risk (Details)
$ in Millions
Dec. 31, 2021
USD ($)
Financial Instruments [Abstract]  
Derivatives in a net liability position $ 372
Collateral posted 382
Derivatives in a net receivable position 477
Cash collateral received $ 581
v3.22.0.1
Other Financial Information - Inventories (Details) - USD ($)
$ in Millions
Dec. 31, 2021
Dec. 31, 2020
Other Financial Information [Abstract]    
Finished goods $ 3,641 $ 2,867
Work in process 4,424 4,436
Raw materials and supplies 994 716
Inventories [1] 9,059 8,020
Noncurrent inventories not included above [2] $ 939 $ 890
[1] The change from December 31, 2020 reflects increases for certain products, including inventory build for new product launches (primarily Comirnaty), network strategy and supply recovery, partially offset by decreases due to market demand.
[2] Included in Other noncurrent assets. There are no recoverability issues for these amounts.
v3.22.0.1
Other Financial Information - Other Current Liabilities (Details) - USD ($)
$ in Millions
Dec. 31, 2021
Dec. 31, 2020
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]    
Other current liabilities $ 24,939 $ 11,561
BioNTech [Member] | Comirnaty direct sales and alliance revenues [Member] | Collaborative Arrangement [Member]    
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]    
Other current liabilities $ 9,700 $ 25
v3.22.0.1
Property, Plant and Equipment (PP&E) - Components of Property, Plant and Equipment (Details) - USD ($)
$ in Millions
 12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Property, Plant and Equipment [Line Items]    
Total property, plant and equipment before accumulated depreciation $ 29,955 $ 28,406
Less: Accumulated depreciation 15,074 14,661
Property, plant and equipment 14,882 13,745
Land [Member]    
Property, Plant and Equipment [Line Items]    
Total property, plant and equipment before accumulated depreciation 423 443
Buildings [Member]    
Property, Plant and Equipment [Line Items]    
Total property, plant and equipment before accumulated depreciation 9,001 8,998
Machinery and equipment [Member]    
Property, Plant and Equipment [Line Items]    
Total property, plant and equipment before accumulated depreciation 12,252 11,000
Furniture, fixtures and other [Member]    
Property, Plant and Equipment [Line Items]    
Total property, plant and equipment before accumulated depreciation 4,457 4,484
Construction in progress [Member]    
Property, Plant and Equipment [Line Items]    
Total property, plant and equipment before accumulated depreciation $ 3,822 $ 3,481
Minimum [Member] | Buildings [Member]    
Property, Plant and Equipment [Line Items]    
Useful lives (years) 33 years  
Minimum [Member] | Machinery and equipment [Member]    
Property, Plant and Equipment [Line Items]    
Useful lives (years) 8 years  
Minimum [Member] | Furniture, fixtures and other [Member]    
Property, Plant and Equipment [Line Items]    
Useful lives (years) 3 years  
Maximum [Member] | Buildings [Member]    
Property, Plant and Equipment [Line Items]    
Useful lives (years) 50 years  
Maximum [Member] | Machinery and equipment [Member]    
Property, Plant and Equipment [Line Items]    
Useful lives (years) 20 years  
Maximum [Member] | Furniture, fixtures and other [Member]    
Property, Plant and Equipment [Line Items]    
Useful lives (years) 12 years 6 months  
v3.22.0.1
Property, Plant, and Equipment (PP&E) - Long-lived Assets by Geographic Areas (Details) - USD ($)
$ in Millions
Dec. 31, 2021
Dec. 31, 2020
Property, Plant and Equipment [Line Items]    
Property, plant and equipment, net $ 14,882 $ 13,745
US [Member]    
Property, Plant and Equipment [Line Items]    
Property, plant and equipment, net 8,385 7,666
Developed Europe [Member]    
Property, Plant and Equipment [Line Items]    
Property, plant and equipment, net 5,094 4,775
Developed Rest Of World [Member]    
Property, Plant and Equipment [Line Items]    
Property, plant and equipment, net 347 413
Emerging Markets [Member]    
Property, Plant and Equipment [Line Items]    
Property, plant and equipment, net $ 1,056 $ 890
v3.22.0.1
Identifiable Intangible Assets and Goodwill - Finite-lived and Indefinite-lived Intangible Assets (Details) - USD ($)
$ in Millions
 12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Finite-Lived Intangible Assets [Line Items]    
Finite-lived intangible assets, gross carrying amount $ 76,552 $ 76,255
Finite-lived intangible assets, accumulated amortization [1] (55,838) (52,493)
Finite-lived intangible assets, less accumulated amortization 20,714 23,762
Indefinite-lived Intangible Assets [Line Items]    
Total indefinite-lived intangible assets 4,432 4,575
Intangible assets, gross carrying amount [1] 80,984 80,830
Identifiable Intangible Assets, less Accumulated Amortization [1] 25,146 28,337
Brands [Member]    
Indefinite-lived Intangible Assets [Line Items]    
Total indefinite-lived intangible assets 827 827
IPR&D [Member]    
Indefinite-lived Intangible Assets [Line Items]    
Total indefinite-lived intangible assets 3,092 3,175
Licensing Agreements and Other [Member]    
Indefinite-lived Intangible Assets [Line Items]    
Total indefinite-lived intangible assets 513 573
Developed Technology Rights [Member]    
Finite-Lived Intangible Assets [Line Items]    
Finite-lived intangible assets, gross carrying amount [2] 73,346 73,040
Finite-lived intangible assets, accumulated amortization [2] (53,732) (50,532)
Finite-lived intangible assets, less accumulated amortization [2] 19,614 22,508
Developed Technology Rights [Member] | BioNTech [Member] | Comirnaty direct sales and alliance revenues [Member]    
Finite-Lived Intangible Assets [Line Items]    
Finite-lived intangible assets period increase (decrease) 500  
Brands [Member]    
Finite-Lived Intangible Assets [Line Items]    
Finite-lived intangible assets, gross carrying amount 922 922
Finite-lived intangible assets, accumulated amortization (807) (774)
Finite-lived intangible assets, less accumulated amortization 115 148
Licensing Agreements and Other [Member]    
Finite-Lived Intangible Assets [Line Items]    
Finite-lived intangible assets, gross carrying amount 2,284 2,292
Finite-lived intangible assets, accumulated amortization (1,299) (1,187)
Finite-lived intangible assets, less accumulated amortization $ 985 $ 1,106
[1] The decrease is primarily due to amortization, partially offset by the capitalization of the Comirnaty milestones described above.
[2] The increase in the gross carrying amount primarily reflects $500 million of capitalized Comirnaty sales milestones to BioNTech, partially offset by net losses from foreign currency translation adjustments.
v3.22.0.1
Identifiable Intangible Assets and Goodwill - Narrative (Details) - USD ($)
$ in Billions
 12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Finite-Lived Intangible Assets [Line Items]      
Finite-lived intangible asset, useful life 8 years    
Amortization expense for finite-lived intangible assets $ 3.7 $ 3.4 $ 4.5
Developed Technology Rights [Member]      
Finite-Lived Intangible Assets [Line Items]      
Finite-lived intangible asset, useful life 7 years    
v3.22.0.1
Identifiable Intangible Assets and Goodwill - Expected Annual Amortization Expense (Details)
$ in Millions
Dec. 31, 2021
USD ($)
Goodwill and Intangible Assets Disclosure [Abstract]  
2022 $ 3,279
2023 2,936
2024 2,686
2025 2,500
2026 $ 2,449
v3.22.0.1
Identifiable Intangible Assets and Goodwill - Goodwill (Details) - USD ($)
$ in Millions
 12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Goodwill [Roll Forward]    
Beginning balance [1] $ 49,556 $ 48,181
Additions [1] 0 727 [2]
Other [1],[3] (348) 648
Ending balance [1] $ 49,208 $ 49,556
[1] As a result of the reorganization of our commercial operations during the fourth quarter of 2021 (see Note 17), we were required to estimate the relative fair values of our PC1 and Hospital organizations to determine any reallocation of goodwill. We completed this analysis and determined that no goodwill was required to be reallocated. As a result, our entire goodwill balance continues to be assigned within the Biopharma reportable segment.
[2] Additions primarily represent the impact of measurement period adjustments related to our Array acquisition (see Note 2A).
[3] Other represents the impact of foreign exchange
v3.22.0.1
Pension and Postretirement Benefit Plans and Defined Contribution Plans - Schedule of Net Periodic Benefit Costs (Details) - USD ($)
$ in Millions
 12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Postretirement Benefits Plan [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Service cost $ 36 $ 38 $ 37
Interest cost 29 49 75
Expected return on plan assets (39) (36) (33)
Amortization of prior service credits/(credits) (151) (170) (173)
Actuarial (gains)/losses [1] (167) (165) (118)
Curtailments (82) 0 (62)
Special termination benefits 2 0 2
Net periodic benefit cost/(credit) reported in income (372) (282) (271)
Cost/(credit) reported in Other comprehensive income/(loss) 107 114 164
Cost/(credit) recognized in Comprehensive income (265) (168) (107)
US [Member] | Pension Plan [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Service cost 0 0 0
Interest cost 455 533 676
Expected return on plan assets (1,052) (1,015) (890)
Amortization of prior service credits/(credits) (2) (3) (4)
Actuarial (gains)/losses [1] (684) 1,152 284
Curtailments 0 0 (4)
Special termination benefits 17 1 20
Net periodic benefit cost/(credit) reported in income (1,265) 668 82
Cost/(credit) reported in Other comprehensive income/(loss) 2 5 4
Cost/(credit) recognized in Comprehensive income (1,264) 674 86
International [Member] | Pension Plan [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Service cost 130 146 125
Interest cost 146 164 215
Expected return on plan assets (327) (314) (318)
Amortization of prior service credits/(credits) (1) (3) (4)
Actuarial (gains)/losses [1] (690) 148 669
Curtailments (4) 0 (1)
Special termination benefits 0 0 0
Net periodic benefit cost/(credit) reported in income (746) 141 686
Cost/(credit) reported in Other comprehensive income/(loss) 4 5 21
Cost/(credit) recognized in Comprehensive income $ (742) $ 145 $ 707
[1] Reflects actuarial remeasurement gains in 2021, primarily due to favorable plan asset performance and increases in discount rates, and actuarial remeasurement losses in 2020 and 2019, primarily due to decreases in discount rates partially offset by favorable plan asset performance.
v3.22.0.1
Pension and Postretirement Benefit Plans and Defined Contribution Plans - Weighted-Average Actuarial Assumptions (Details)
 12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Postretirement Benefits Plan [Member]      
Weighted-average assumptions used to determine net periodic benefit cost:      
Discount rate: Pension plans/postretirement plans 2.50% 3.20% 4.30%
Expected return on plan assets 6.80% 7.00% 7.30%
Weighted-average assumptions used to determine benefit obligations at fiscal year-end:      
Discount rate 2.90% 2.50% 3.20%
US [Member] | Pension Plan [Member]      
Weighted-average assumptions used to determine net periodic benefit cost:      
Discount rate: Pension plans/postretirement plans 2.60% 3.30% 4.40%
Expected return on plan assets 6.80% 7.00% 7.20%
Weighted-average assumptions used to determine benefit obligations at fiscal year-end:      
Discount rate 2.90% 2.60% 3.30%
International [Member] | Pension Plan [Member]      
Weighted-average assumptions used to determine net periodic benefit cost:      
Discount rate: Interest cost 1.20% 1.50% 2.20%
Discount rate: Service cost 1.40% 1.60% 2.40%
Expected return on plan assets 3.40% 3.60% 3.90%
Rate of compensation increase 2.90% 2.90% 1.40%
Weighted-average assumptions used to determine benefit obligations at fiscal year-end:      
Discount rate 1.60% 1.50% 1.70%
Rate of compensation increase [1] 2.80% 2.90% 1.40%
[1] The rate of compensation increase is not used to determine the net periodic benefit cost and benefit obligation for the U.S. pension plans as these plans are frozen.
v3.22.0.1
Pension and Postretirement Benefit Plans and Defined Contribution Plans - Healthcare Cost Trend Rate Assumptions (Details) - Postretirement Benefits Plan [Member]
Dec. 31, 2021
Dec. 31, 2020
Defined Benefit Plan Disclosure [Line Items]    
Healthcare cost trend rate assumed for next year 6.00% 5.60%
Rate to which the cost trend rate is assumed to decline 4.00% 4.50%
v3.22.0.1
Pension and Postretirement Benefit Plans and Defined Contribution Plans - Obligations and Funded Status (Details) - USD ($)
$ in Millions
 12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Postretirement Benefits Plan [Member]      
Change in benefit obligation      
Benefit obligation, beginning [1] $ 1,238 $ 1,667  
Service cost 36 38 $ 37
Interest cost 29 49 75
Employee contributions 78 88  
Plan amendments (116) (56)  
Changes in actuarial assumptions and other [2] (117) (132)  
Foreign exchange impact 1 2  
Upjohn spin-off [3] 0 (218)  
Acquisitions/divestitures/other, net 0    
Curtailments and special termination benefits (8) 0  
Settlements 0 0  
Benefits paid (147) (201)  
Benefit obligation, ending [1] 995 1,238 1,667
Change in plan assets      
Fair value, beginning 588 519  
Actual return on plan assets 89 69  
Company contributions 145 113  
Employee contributions 78 88  
Foreign exchange impact 0 0  
Upjohn spin-off [3] 0 0  
Acquisitions/divestitures, net 0 0  
Settlements 0 0  
Benefits paid (147) (201)  
Fair value, ending 753 588 519
Funded status—Plan assets less than benefit obligation (241) (651)  
Amounts recorded in our consolidated balance sheet:      
Noncurrent assets 0 0  
Current liabilities (6) (6)  
Noncurrent liabilities (235) (645)  
Funded status (241) (651)  
Pre-tax components of cumulative amounts recognized in Accumulated other comprehensive loss:      
Prior service (costs)/credits 581 688  
US [Member] | Pension Plan [Member]      
Change in benefit obligation      
Benefit obligation, beginning [1] 18,306 17,886  
Service cost 0 0 0
Interest cost 455 533 676
Employee contributions 0 0  
Plan amendments 0 2  
Changes in actuarial assumptions and other [2] (331) 2,112  
Foreign exchange impact 0 0  
Upjohn spin-off [3] 0 (1,016)  
Acquisitions/divestitures/other, net 0 0  
Curtailments and special termination benefits 17 1  
Settlements (785) (767)  
Benefits paid (512) (445)  
Benefit obligation, ending [1] 17,150 18,306 17,886
Change in plan assets      
Fair value, beginning 16,094 14,586  
Actual return on plan assets 1,405 1,974  
Company contributions 143 1,433  
Employee contributions 0 0  
Foreign exchange impact 0 0  
Upjohn spin-off [3] 0 (687)  
Settlements (785) (767)  
Benefits paid (512) (445)  
Fair value, ending 16,346 16,094 14,586
Funded status—Plan assets less than benefit obligation (805) (2,211)  
Amounts recorded in our consolidated balance sheet:      
Noncurrent assets 447 0  
Current liabilities (138) (127)  
Noncurrent liabilities (1,113) (2,084)  
Funded status (805) (2,211)  
Pre-tax components of cumulative amounts recognized in Accumulated other comprehensive loss:      
Prior service (costs)/credits (6) (4)  
Pension plans with an ABO in excess of plan assets:      
Fair value of plan assets [4] 120 16,094  
ABO [4] 1,371 18,306  
Pension plans with a PBO in excess of plan assets:      
Fair value of plan assets [4] 120 16,094  
PBO [4] 1,371 18,306  
US [Member] | Postretirement Benefits Plan [Member]      
Change in plan assets      
Fair value, beginning [5] 588    
Fair value, ending [5] 753 588  
International [Member] | Pension Plan [Member]      
Change in benefit obligation      
Benefit obligation, beginning [1] 12,001 11,059  
Service cost 130 146 125
Interest cost 146 164 215
Employee contributions 10 8  
Plan amendments 0 2  
Changes in actuarial assumptions and other [2] 89 702  
Foreign exchange impact (298) 646  
Upjohn spin-off [3] 3 (320)  
Acquisitions/divestitures/other, net 0 0  
Curtailments and special termination benefits (2) 0  
Settlements (47) (34)  
Benefits paid (374) (372)  
Benefit obligation, ending [1] 11,657 12,001 11,059
Change in plan assets      
Fair value, beginning 9,811 8,956  
Actual return on plan assets 1,106 868  
Company contributions 451 197  
Employee contributions 10 8  
Foreign exchange impact (229) 462  
Upjohn spin-off [3] 2 (270)  
Acquisitions/divestitures, net   (6)  
Settlements (47) (34)  
Benefits paid (374) (372)  
Fair value, ending 10,729 9,811 $ 8,956
Funded status—Plan assets less than benefit obligation (928) (2,191)  
Amounts recorded in our consolidated balance sheet:      
Noncurrent assets 1,480 522  
Current liabilities (33) (31)  
Noncurrent liabilities (2,376) (2,681)  
Funded status (928) (2,191)  
Pre-tax components of cumulative amounts recognized in Accumulated other comprehensive loss:      
Prior service (costs)/credits (35) (31)  
Pension plans with an ABO in excess of plan assets:      
Fair value of plan assets [4] 1,304 6,674  
ABO [4] 3,344 8,961  
Pension plans with a PBO in excess of plan assets:      
Fair value of plan assets [4] 1,381 6,735  
PBO [4] 3,789 9,447  
Defined benefit plan, accumulated benefit obligation $ 11,200 $ 11,500  
[1] For the U.S. pension plans, the benefit obligation is both the PBO and ABO as these plans are frozen and future benefit accruals no longer increase with future compensation increases. For the international pension plans, the benefit obligation is the PBO. The ABO for our international pension plans was $11.2 billion in 2021 and $11.5 billion in 2020. For the postretirement plans, the benefit obligation is the ABO.
[2] Primarily includes actuarial gains resulting from increases in discount rates in 2021, offset by increases in inflation assumptions in 2021 for the international plans, and actuarial losses resulting from decreases in discount rates in 2020.
[3] For more information, see Note 2B.
[4] Our main U.S. qualified plan and many of our international plans were overfunded as of December 31, 2021.
[5] Reflects postretirement plan assets, which support a portion of our U.S. retiree medical plans.
v3.22.0.1
Pension and Postretirement Benefit Plans and Defined Contribution Plans - Plan Assets (Details) - USD ($)
$ in Millions
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Postretirement Benefits Plan [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Fair value of plan assets $ 753 $ 588 $ 519
US [Member] | Pension Plan [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Equity and debt securities, target allocation percentage 100.00%    
Fair value of plan assets $ 16,346 16,094 14,586
US [Member] | Pension Plan [Member] | Level 1 [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Fair value of plan assets 2,332 3,306  
US [Member] | Pension Plan [Member] | Level 2 [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Fair value of plan assets 10,726 10,103  
US [Member] | Pension Plan [Member] | Level 3 [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Fair value of plan assets 2 1  
US [Member] | Pension Plan [Member] | Assets Measured at NAV [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Fair value of plan assets [1] 3,286 2,684  
US [Member] | Pension Plan [Member] | Cash and cash equivalents [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Fair value of plan assets $ 1,326 781  
US [Member] | Pension Plan [Member] | Cash and cash equivalents [Member] | Minimum [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Equity and debt securities, target allocation percentage 0.00%    
US [Member] | Pension Plan [Member] | Cash and cash equivalents [Member] | Maximum [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Equity and debt securities, target allocation percentage 10.00%    
US [Member] | Pension Plan [Member] | Cash and cash equivalents [Member] | Level 1 [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Fair value of plan assets $ 78 70  
US [Member] | Pension Plan [Member] | Cash and cash equivalents [Member] | Level 2 [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Fair value of plan assets 1,248 711  
US [Member] | Pension Plan [Member] | Cash and cash equivalents [Member] | Level 3 [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Fair value of plan assets 0 0  
US [Member] | Pension Plan [Member] | Cash and cash equivalents [Member] | Assets Measured at NAV [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Fair value of plan assets [1] $ 0 0  
US [Member] | Pension Plan [Member] | Equity securities [Member] | Minimum [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Equity and debt securities, target allocation percentage 20.00%    
US [Member] | Pension Plan [Member] | Equity securities [Member] | Maximum [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Equity and debt securities, target allocation percentage 40.00%    
US [Member] | Pension Plan [Member] | Global Equity Securities [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Fair value of plan assets $ 2,273 3,241  
US [Member] | Pension Plan [Member] | Global Equity Securities [Member] | Level 1 [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Fair value of plan assets 2,233 3,213  
US [Member] | Pension Plan [Member] | Global Equity Securities [Member] | Level 2 [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Fair value of plan assets 38 27  
US [Member] | Pension Plan [Member] | Global Equity Securities [Member] | Level 3 [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Fair value of plan assets 2 1  
US [Member] | Pension Plan [Member] | Global Equity Securities [Member] | Assets Measured at NAV [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Fair value of plan assets [1] 0 0  
US [Member] | Pension Plan [Member] | Equity commingled funds [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Fair value of plan assets 1,352 1,325  
US [Member] | Pension Plan [Member] | Equity commingled funds [Member] | Level 1 [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Fair value of plan assets 0 0  
US [Member] | Pension Plan [Member] | Equity commingled funds [Member] | Level 2 [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Fair value of plan assets 1,152 1,110  
US [Member] | Pension Plan [Member] | Equity commingled funds [Member] | Level 3 [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Fair value of plan assets 0 0  
US [Member] | Pension Plan [Member] | Equity commingled funds [Member] | Assets Measured at NAV [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Fair value of plan assets [1] $ 200 215  
US [Member] | Pension Plan [Member] | Fixed income securities [Member] | Minimum [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Equity and debt securities, target allocation percentage 45.00%    
US [Member] | Pension Plan [Member] | Fixed income securities [Member] | Maximum [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Equity and debt securities, target allocation percentage 75.00%    
US [Member] | Pension Plan [Member] | Corporate debt [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Fair value of plan assets $ 5,566 6,499  
US [Member] | Pension Plan [Member] | Corporate debt [Member] | Level 1 [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Fair value of plan assets 18 23  
US [Member] | Pension Plan [Member] | Corporate debt [Member] | Level 2 [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Fair value of plan assets 5,548 6,476  
US [Member] | Pension Plan [Member] | Corporate debt [Member] | Level 3 [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Fair value of plan assets 0    
US [Member] | Pension Plan [Member] | Corporate debt [Member] | Assets Measured at NAV [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Fair value of plan assets [1] 0    
US [Member] | Pension Plan [Member] | Government and Agency Obligations [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Fair value of plan assets [2] 2,533 1,555  
US [Member] | Pension Plan [Member] | Government and Agency Obligations [Member] | Level 1 [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Fair value of plan assets [2] 0 0  
US [Member] | Pension Plan [Member] | Government and Agency Obligations [Member] | Level 2 [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Fair value of plan assets [2] 2,533 1,555  
US [Member] | Pension Plan [Member] | Government and Agency Obligations [Member] | Level 3 [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Fair value of plan assets [2] 0 0  
US [Member] | Pension Plan [Member] | Government and Agency Obligations [Member] | Assets Measured at NAV [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Fair value of plan assets [1],[2] 0 0  
US [Member] | Pension Plan [Member] | Fixed Income Commingled Funds [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Fair value of plan assets 38 23  
US [Member] | Pension Plan [Member] | Fixed Income Commingled Funds [Member] | Level 1 [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Fair value of plan assets   0  
US [Member] | Pension Plan [Member] | Fixed Income Commingled Funds [Member] | Level 2 [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Fair value of plan assets 38 23  
US [Member] | Pension Plan [Member] | Fixed Income Commingled Funds [Member] | Level 3 [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Fair value of plan assets 0 0  
US [Member] | Pension Plan [Member] | Fixed Income Commingled Funds [Member] | Assets Measured at NAV [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Fair value of plan assets [1] $ 0 0  
US [Member] | Pension Plan [Member] | Other investments [Member] | Minimum [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Equity and debt securities, target allocation percentage 5.00%    
US [Member] | Pension Plan [Member] | Other investments [Member] | Maximum [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Equity and debt securities, target allocation percentage 20.00%    
US [Member] | Pension Plan [Member] | Partnership Interest [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Fair value of plan assets [3] $ 2,079 1,431  
US [Member] | Pension Plan [Member] | Partnership Interest [Member] | Level 1 [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Fair value of plan assets [3] 3 0  
US [Member] | Pension Plan [Member] | Partnership Interest [Member] | Level 2 [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Fair value of plan assets [3]   0  
US [Member] | Pension Plan [Member] | Partnership Interest [Member] | Level 3 [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Fair value of plan assets [3] 0 0  
US [Member] | Pension Plan [Member] | Partnership Interest [Member] | Assets Measured at NAV [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Fair value of plan assets [1],[3] 2,076 1,431  
US [Member] | Pension Plan [Member] | Insurance Contracts [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Fair value of plan assets 158 190  
US [Member] | Pension Plan [Member] | Insurance Contracts [Member] | Level 1 [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Fair value of plan assets 0 0  
US [Member] | Pension Plan [Member] | Insurance Contracts [Member] | Level 2 [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Fair value of plan assets 158 190  
US [Member] | Pension Plan [Member] | Insurance Contracts [Member] | Level 3 [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Fair value of plan assets 0 0  
US [Member] | Pension Plan [Member] | Insurance Contracts [Member] | Assets Measured at NAV [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Fair value of plan assets [1] 0 0  
US [Member] | Pension Plan [Member] | Other Commingled Funds [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Fair value of plan assets [4] 1,019 1,049  
US [Member] | Pension Plan [Member] | Other Commingled Funds [Member] | Level 1 [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Fair value of plan assets [4] 0 0  
US [Member] | Pension Plan [Member] | Other Commingled Funds [Member] | Level 2 [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Fair value of plan assets [4] 10 11  
US [Member] | Pension Plan [Member] | Other Commingled Funds [Member] | Level 3 [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Fair value of plan assets [4] 0 0  
US [Member] | Pension Plan [Member] | Other Commingled Funds [Member] | Assets Measured at NAV [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Fair value of plan assets [1],[4] $ 1,009 1,038  
US [Member] | Postretirement Benefits Plan [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Equity and debt securities, target allocation percentage [5] 100.00%    
Fair value of plan assets [5] $ 753 588  
US [Member] | Postretirement Benefits Plan [Member] | Level 1 [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Fair value of plan assets [5] 3    
US [Member] | Postretirement Benefits Plan [Member] | Level 2 [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Fair value of plan assets [5] 750 588  
US [Member] | Postretirement Benefits Plan [Member] | Level 3 [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Fair value of plan assets [5]   0  
US [Member] | Postretirement Benefits Plan [Member] | Assets Measured at NAV [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Fair value of plan assets [1],[5]   0  
US [Member] | Postretirement Benefits Plan [Member] | Cash and cash equivalents [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Fair value of plan assets [5] $ 85 0  
US [Member] | Postretirement Benefits Plan [Member] | Cash and cash equivalents [Member] | Minimum [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Equity and debt securities, target allocation percentage 0.00%    
US [Member] | Postretirement Benefits Plan [Member] | Cash and cash equivalents [Member] | Maximum [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Equity and debt securities, target allocation percentage 5.00%    
US [Member] | Postretirement Benefits Plan [Member] | Cash and cash equivalents [Member] | Level 1 [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Fair value of plan assets [5] $ 3    
US [Member] | Postretirement Benefits Plan [Member] | Cash and cash equivalents [Member] | Level 2 [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Fair value of plan assets [5] 82 0  
US [Member] | Postretirement Benefits Plan [Member] | Cash and cash equivalents [Member] | Level 3 [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Fair value of plan assets [5]   0  
US [Member] | Postretirement Benefits Plan [Member] | Cash and cash equivalents [Member] | Assets Measured at NAV [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Fair value of plan assets [1],[5]   0  
US [Member] | Postretirement Benefits Plan [Member] | Insurance Contracts [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Fair value of plan assets [5] $ 669 588  
US [Member] | Postretirement Benefits Plan [Member] | Insurance Contracts [Member] | Minimum [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Equity and debt securities, target allocation percentage 95.00%    
US [Member] | Postretirement Benefits Plan [Member] | Insurance Contracts [Member] | Maximum [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Equity and debt securities, target allocation percentage 100.00%    
US [Member] | Postretirement Benefits Plan [Member] | Insurance Contracts [Member] | Level 1 [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Fair value of plan assets [5] $ 0    
US [Member] | Postretirement Benefits Plan [Member] | Insurance Contracts [Member] | Level 2 [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Fair value of plan assets [5] $ 669 588  
US [Member] | Postretirement Benefits Plan [Member] | Insurance Contracts [Member] | Level 3 [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Fair value of plan assets [5]   0  
US [Member] | Postretirement Benefits Plan [Member] | Insurance Contracts [Member] | Assets Measured at NAV [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Fair value of plan assets [1],[5]   0  
International [Member] | Pension Plan [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Equity and debt securities, target allocation percentage 100.00%    
Fair value of plan assets $ 10,729 9,811 8,956
International [Member] | Pension Plan [Member] | Level 1 [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Fair value of plan assets 191 61  
International [Member] | Pension Plan [Member] | Level 2 [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Fair value of plan assets 6,672 5,681  
International [Member] | Pension Plan [Member] | Level 3 [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Fair value of plan assets 1,677 1,362 $ 1,342
International [Member] | Pension Plan [Member] | Assets Measured at NAV [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Fair value of plan assets [1] 2,189 2,707  
International [Member] | Pension Plan [Member] | Cash and cash equivalents [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Fair value of plan assets $ 541 407  
International [Member] | Pension Plan [Member] | Cash and cash equivalents [Member] | Minimum [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Equity and debt securities, target allocation percentage 0.00%    
International [Member] | Pension Plan [Member] | Cash and cash equivalents [Member] | Maximum [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Equity and debt securities, target allocation percentage 10.00%    
International [Member] | Pension Plan [Member] | Cash and cash equivalents [Member] | Level 1 [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Fair value of plan assets $ 191 61  
International [Member] | Pension Plan [Member] | Cash and cash equivalents [Member] | Level 2 [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Fair value of plan assets 346 346  
International [Member] | Pension Plan [Member] | Cash and cash equivalents [Member] | Level 3 [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Fair value of plan assets 0 0  
International [Member] | Pension Plan [Member] | Cash and cash equivalents [Member] | Assets Measured at NAV [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Fair value of plan assets [1] $ 3 0  
International [Member] | Pension Plan [Member] | Equity securities [Member] | Minimum [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Equity and debt securities, target allocation percentage 10.00%    
International [Member] | Pension Plan [Member] | Equity securities [Member] | Maximum [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Equity and debt securities, target allocation percentage 20.00%    
International [Member] | Pension Plan [Member] | Equity commingled funds [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Fair value of plan assets $ 1,453 2,051  
International [Member] | Pension Plan [Member] | Equity commingled funds [Member] | Level 1 [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Fair value of plan assets 0 0  
International [Member] | Pension Plan [Member] | Equity commingled funds [Member] | Level 2 [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Fair value of plan assets 1,386 1,681  
International [Member] | Pension Plan [Member] | Equity commingled funds [Member] | Level 3 [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Fair value of plan assets 0 0  
International [Member] | Pension Plan [Member] | Equity commingled funds [Member] | Assets Measured at NAV [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Fair value of plan assets [1] $ 67 370  
International [Member] | Pension Plan [Member] | Fixed income securities [Member] | Minimum [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Equity and debt securities, target allocation percentage 45.00%    
International [Member] | Pension Plan [Member] | Fixed income securities [Member] | Maximum [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Equity and debt securities, target allocation percentage 70.00%    
International [Member] | Pension Plan [Member] | Corporate debt [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Fair value of plan assets $ 1,187 925  
International [Member] | Pension Plan [Member] | Corporate debt [Member] | Level 1 [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Fair value of plan assets 0 0  
International [Member] | Pension Plan [Member] | Corporate debt [Member] | Level 2 [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Fair value of plan assets 1,187 925  
International [Member] | Pension Plan [Member] | Corporate debt [Member] | Level 3 [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Fair value of plan assets 0 0  
International [Member] | Pension Plan [Member] | Corporate debt [Member] | Assets Measured at NAV [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Fair value of plan assets [1] 0 0  
International [Member] | Pension Plan [Member] | Government and Agency Obligations [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Fair value of plan assets [2] 2,415 1,334  
International [Member] | Pension Plan [Member] | Government and Agency Obligations [Member] | Level 1 [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Fair value of plan assets [2] 0 0  
International [Member] | Pension Plan [Member] | Government and Agency Obligations [Member] | Level 2 [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Fair value of plan assets [2] 2,415 1,334  
International [Member] | Pension Plan [Member] | Government and Agency Obligations [Member] | Level 3 [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Fair value of plan assets [2] 0 0  
International [Member] | Pension Plan [Member] | Government and Agency Obligations [Member] | Assets Measured at NAV [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Fair value of plan assets [1],[2] 0 0  
International [Member] | Pension Plan [Member] | Fixed Income Commingled Funds [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Fair value of plan assets 2,266 2,484  
International [Member] | Pension Plan [Member] | Fixed Income Commingled Funds [Member] | Level 1 [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Fair value of plan assets 0 0  
International [Member] | Pension Plan [Member] | Fixed Income Commingled Funds [Member] | Level 2 [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Fair value of plan assets 1,138 1,217  
International [Member] | Pension Plan [Member] | Fixed Income Commingled Funds [Member] | Level 3 [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Fair value of plan assets 0 0  
International [Member] | Pension Plan [Member] | Fixed Income Commingled Funds [Member] | Assets Measured at NAV [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Fair value of plan assets [1] $ 1,128 1,267  
International [Member] | Pension Plan [Member] | Other investments [Member] | Minimum [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Equity and debt securities, target allocation percentage 15.00%    
International [Member] | Pension Plan [Member] | Other investments [Member] | Maximum [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Equity and debt securities, target allocation percentage 35.00%    
International [Member] | Pension Plan [Member] | Partnership Interest [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Fair value of plan assets [3] $ 107 69  
International [Member] | Pension Plan [Member] | Partnership Interest [Member] | Level 1 [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Fair value of plan assets [3] 0 0  
International [Member] | Pension Plan [Member] | Partnership Interest [Member] | Level 2 [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Fair value of plan assets [3] 2 3  
International [Member] | Pension Plan [Member] | Partnership Interest [Member] | Level 3 [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Fair value of plan assets [3] 0 0  
International [Member] | Pension Plan [Member] | Partnership Interest [Member] | Assets Measured at NAV [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Fair value of plan assets [1],[3] 106 66  
International [Member] | Pension Plan [Member] | Insurance Contracts [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Fair value of plan assets 1,329 1,027  
International [Member] | Pension Plan [Member] | Insurance Contracts [Member] | Level 1 [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Fair value of plan assets 0 0  
International [Member] | Pension Plan [Member] | Insurance Contracts [Member] | Level 2 [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Fair value of plan assets 56 57  
International [Member] | Pension Plan [Member] | Insurance Contracts [Member] | Level 3 [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Fair value of plan assets 1,273 969  
International [Member] | Pension Plan [Member] | Insurance Contracts [Member] | Assets Measured at NAV [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Fair value of plan assets [1] 0 1  
International [Member] | Pension Plan [Member] | Other [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Fair value of plan assets [4] 1,431 1,514  
International [Member] | Pension Plan [Member] | Other [Member] | Level 1 [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Fair value of plan assets [4] 0 0  
International [Member] | Pension Plan [Member] | Other [Member] | Level 2 [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Fair value of plan assets [4] 141 117  
International [Member] | Pension Plan [Member] | Other [Member] | Level 3 [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Fair value of plan assets [4] 404 393  
International [Member] | Pension Plan [Member] | Other [Member] | Assets Measured at NAV [Member]      
Defined Benefit Plan Disclosure [Line Items]      
Fair value of plan assets [1],[4] $ 886 $ 1,003  
[1] Certain investments that are measured at NAV per share (or its equivalent) have not been classified in the fair value hierarchy. The NAV amounts presented in this table are intended to permit reconciliation of the fair value hierarchy to the amounts presented for the total pension benefits plan assets.
[2] Government and agency obligations are inclusive of repurchase agreements
[3] Mainly includes investments in private equity, private debt, public equity limited partnerships, and, to a lesser extent, real estate and venture capital.
[4] Mostly includes investments in hedge funds and real estate.
[5] Reflects postretirement plan assets, which support a portion of our U.S. retiree medical plans.
v3.22.0.1
Pension and Postretirement Benefit Plans and Defined Contribution Plans - Analysis of Changes in Significant Investments Valued Using Significant Unobservable Inputs (Details) - International [Member] - Pension Plan [Member] - USD ($)
$ in Millions
 12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Defined Benefit Plan, Change in Fair Value of Plan Assets, Level 3 Reconciliation [Roll Forward]    
Fair value, beginning $ 9,811 $ 8,956
Actual return on plan assets:    
Exchange rate changes (229) 462
Fair value, ending 10,729 9,811
Level 3 [Member]    
Defined Benefit Plan, Change in Fair Value of Plan Assets, Level 3 Reconciliation [Roll Forward]    
Fair value, beginning 1,362 1,342
Actual return on plan assets:    
Assets held, ending 23 22
Purchases, sales, and settlements, net 52 (47)
Transfer into/(out of) Level 3 265 (13)
Exchange rate changes (24) 58
Fair value, ending $ 1,677 $ 1,362
v3.22.0.1
Pension and Postretirement Benefit Plans and Defined Contribution Plans - Expected Future Cash Flow Information (Details)
$ in Millions
Dec. 31, 2021
USD ($)
Postretirement Benefits Plan [Member]  
Defined Benefit Plan Disclosure [Line Items]  
Expected contributions in 2022 $ 74
Expected benefit payments:  
2022 78
2023 73
2024 69
2025 66
2026 68
2027–2031 359
US [Member] | Pension Plan [Member]  
Defined Benefit Plan Disclosure [Line Items]  
Expected contributions in 2022 138
Expected benefit payments:  
2022 1,296
2023 1,155
2024 1,140
2025 1,089
2026 1,058
2027–2031 4,908
International [Member] | Pension Plan [Member]  
Defined Benefit Plan Disclosure [Line Items]  
Expected contributions in 2022 177
Expected benefit payments:  
2022 384
2023 372
2024 383
2025 392
2026 397
2027–2031 $ 2,124
v3.22.0.1
Pension and Postretirement Benefit Plans and Defined Contribution Plans - Narrative (Details) - USD ($)
$ in Millions
 12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Retirement Benefits [Abstract]      
Defined contribution plan, cost recognized $ 732 $ 685 $ 659
v3.22.0.1
Equity - Narrative (Details)
 1 Months Ended 12 Months Ended
May 04, 2020
shares
Aug. 31, 2019
$ / shares
shares
Feb. 28, 2019
USD ($)
shares
Dec. 31, 2021
USD ($)
employeeStockOwnershipPlan
shares
Dec. 31, 2020
USD ($)
shares
Dec. 31, 2019
USD ($)
shares
Dec. 31, 2018
USD ($)
Dec. 31, 2017
USD ($)
Equity, Class of Treasury Stock [Line Items]                
Shares repurchased | shares       0 0 213,000,000 [1]    
Amount of remaining shares authorized in stock purchase plan, value       $ 5,300,000,000        
Preferred stock, shares outstanding | shares 0     0 0      
Number of employee stock ownership plans | employeeStockOwnershipPlan       1        
Common Stock [Member]                
Equity, Class of Treasury Stock [Line Items]                
Shares issued upon conversion of convertible preferred stock (in shares) | shares 1,070,369              
Common ESOP Plan [Member]                
Equity, Class of Treasury Stock [Line Items]                
ESOP compensation expense       $ 19,000,000 $ 19,000,000 $ 20,000,000    
December 2017 Stock Purchase Plan [Member]                
Equity, Class of Treasury Stock [Line Items]                
Amount of shares authorized in stock purchase plan, value               $ 10,000,000,000
December 2018 Stock Purchase Plan [Member]                
Equity, Class of Treasury Stock [Line Items]                
Amount of shares authorized in stock purchase plan, value             $ 10,000,000,000  
Share Repurchase Agreement with Goldman, Sachs & Co. LLC [Member]                
Equity, Class of Treasury Stock [Line Items]                
Amount of shares authorized in stock purchase plan, value     $ 6,800,000,000          
Accelerated share repurchases, cash paid     $ 6,800,000,000          
Shares repurchased | shares   33,500,000 130,000,000          
Accelerated share repurchase, percentage of agreement     80.00%          
Accelerated share repurchase, final average price paid (in dollars per share) | $ / shares   $ 41.42            
[1] Represents shares purchased pursuant to the ASR with Goldman Sachs & Co. LLC entered into in February 2019, as well as open market share repurchases of $2.1 billion
v3.22.0.1
Equity - Summary of Common Stock Purchases (Details) - USD ($)
shares in Millions, $ in Millions
 12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Equity, Class of Treasury Stock [Line Items]      
Shares of common stock purchased 0 0 213 [1]
Cost of purchase $ 0 $ 0 $ 8,865 [1]
Open Market Purchases [Member]      
Equity, Class of Treasury Stock [Line Items]      
Cost of purchase     $ 2,100
[1] Represents shares purchased pursuant to the ASR with Goldman Sachs & Co. LLC entered into in February 2019, as well as open market share repurchases of $2.1 billion
v3.22.0.1
Share-Based Payments - Narrative (Detail) - USD ($)
$ in Millions
 12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]      
Shares available for award 315,000,000    
Compensation cost recognized, pre-tax $ 1,200 $ 780 $ 718
Tax benefit for share-based compensation expense 227 141 137
Discontinued Operations [Member]      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]      
Compensation cost recognized, pre-tax $ 2 25 32
2019 Stock Plan [Member]      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]      
Number of additional shares authorized 400,000,000    
Award requisite service period 36 months    
Maximum shares available per individual during the plan period 20,000,000    
Restricted Stock Units (RSUs) [Member]      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]      
Compensation cost recognized, pre-tax [1] $ 281 272 275
Restricted Stock Units (RSUs) [Member] | 2019 Stock Plan [Member]      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]      
Number of shares counted toward maximum 3    
Portfolio Performance Shares [Member]      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]      
Compensation cost recognized, pre-tax [1] $ 535 180 114
Portfolio Performance Shares [Member] | 2019 Stock Plan [Member]      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]      
Number of shares counted toward maximum 3    
Performance Share Awards [Member]      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]      
Award requisite service period 3 years    
Compensation cost recognized, pre-tax [1] $ 76 31 28
Performance Share Awards [Member] | 2019 Stock Plan [Member]      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]      
Number of shares counted toward maximum 3    
Total Shareholder Return Units (TSRUs) [Member]      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]      
Compensation cost recognized, pre-tax [1] $ 259 287 294
Total Shareholder Return Units (TSRUs) [Member] | 2019 Stock Plan [Member]      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]      
Number of shares counted toward maximum 1    
Share-based Payment Arrangement, Option [Member]      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]      
Compensation cost recognized, pre-tax [1] $ 5 $ 6 $ 7
Share-based Payment Arrangement, Option [Member] | 2019 Stock Plan [Member]      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]      
Number of shares counted toward maximum 1    
[1] TSRU includes expense for PTSRUs, which is not significant for all years presented
v3.22.0.1
Share-Based Payments - Schedule of Share-based Compensation Awards and Valuation Details (Details)
 12 Months Ended
Dec. 31, 2021
measure
period
tradingDay
shares
Dec. 31, 2017
$ / shares
shares
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]    
Granted, shares 779,000  
Management [Member]    
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]    
Granted, shares 0  
Total Shareholder Return Units (TSRUs) [Member]    
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]    
Trading day average | tradingDay [1],[2] 20  
Total Shareholder Return Units (TSRUs) [Member] | Minimum [Member]    
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]    
Contractual term (years) [1],[2] 5 years  
Total Shareholder Return Units (TSRUs) [Member] | Maximum [Member]    
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]    
Contractual term (years) [1],[2] 7 years  
Portfolio Performance Shares [Member] | Minimum [Member]    
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]    
Award requisite service period 3 years  
Number of shares earned as a percentage of initial award 0.00%  
Portfolio Performance Shares [Member] | Maximum [Member]    
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]    
Award requisite service period 5 years  
Number of shares earned as a percentage of initial award 200.00%  
Performance Share Awards [Member]    
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]    
Award requisite service period 3 years  
Number of measures used to determine share payout | measure 2  
Share payout measures, adjusted net income, number of periods | period 3  
Share payout measures, adjusted net income, period 1 year  
Performance Share Awards [Member] | Minimum [Member]    
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]    
Number of shares earned as a percentage of initial award 0.00%  
Performance Share Awards [Member] | Maximum [Member]    
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]    
Number of shares earned as a percentage of initial award 200.00%  
Breakthrough Performance Awards (BPAs) [Member]    
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]    
Award requisite service period 1 year  
Breakthrough Performance Awards (BPAs) [Member] | Minimum [Member]    
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]    
Number of shares earned as a percentage of initial award 0.00%  
Breakthrough Performance Awards (BPAs) [Member] | Maximum [Member]    
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]    
Number of shares earned as a percentage of initial award 600.00%  
Share-based Payment Arrangement, Option [Member]    
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]    
Contractual term (years) 10 years  
Performance Total Shareholder Return Unit (PTSRUs) [Member]    
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]    
Grant price (in dollars per share) | $ / shares   $ 30.31
Grant-date fair value (in dollars per share) | $ / shares   $ 5.54
Performance Total Shareholder Return Unit (PTSRUs) [Member] | Board of Directors Chairman [Member]    
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]    
Deferred compensation arrangement, shares issued   1,444,395
Performance Total Shareholder Return Unit (PTSRUs) [Member] | Group President, Chief Business Officer or Former Group President, Pfizer Innovative Health [Member]    
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]    
Deferred compensation arrangement, shares issued   361,099
[1] In 2017, Performance Total Shareholder Return Units (PTSRUs) were awarded to the Former Chairman and Chief Executive Officer (1,444,395 PTSRUs) and 361,099 PTSRUs were awarded to the Group President, Chief Business Officer (former role Group President Pfizer Innovative Health) at a grant price of $30.31 and at a GDFV of $5.54 per PTSRU. In addition to having the same characteristics and valuation methodology of TSRUs, PTSRU grants require special service and performance conditions
[2] Retirement-eligible holders, as defined in the grant terms, can convert their TSRUs, when vested, into Profit Units (PTUs) with a conversion ratio based on a calculation used to determine the shares at TSRU settlement. The PTUs are entitled to earn Dividend Equivalent Units (DEUs), and the PTUs and DEUs will be settled in our common stock on the TSRUs’ original settlement date and will be subject to the terms and conditions of the original grant including forfeiture provisions.
v3.22.0.1
Share-Based Payments - Summary of Data Related to Share-based Payment Arrangement Activity (Details) - USD ($)
$ / shares in Units, $ in Millions
 12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]      
Compensation cost recognized, pre-tax $ 1,200 $ 780 $ 718
Total Shareholder Return Units (TSRUs) [Member]      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]      
Granted, weighted-average grant-date fair value per share (in dollars per share) [1] $ 7.26 $ 6.22 $ 8.52
Units converted, aggregate intrinsic value $ 594 $ 84 $ 175
Compensation cost recognized, pre-tax [2] 259 287 294
Total compensation cost related to nonvested awards not yet recognized, pre-tax $ 187 $ 224 $ 229
Weighted-average period over which cost is expected to be recognized (years) 1 year 7 months 6 days 1 year 7 months 6 days 1 year 7 months 6 days
Restricted Stock Units (RSUs) [Member]      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]      
Granted, weighted-average grant-date fair value per share (in dollars per share) $ 34.31    
Total fair value of shares vested [1] $ 304 $ 334 $ 454
Compensation cost recognized, pre-tax [2] 281 272 275
Total compensation cost related to nonvested awards not yet recognized, pre-tax $ 271 $ 228 $ 241
Weighted-average period over which cost is expected to be recognized (years) 1 year 9 months 18 days 1 year 8 months 12 days 1 year 8 months 12 days
Portfolio Performance Shares [Member]      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]      
Total fair value of shares vested [1] $ 181 $ 119 $ 136
Units converted, aggregate intrinsic value 228 224 245
Compensation cost recognized, pre-tax [2] 535 180 114
Total compensation cost related to nonvested awards not yet recognized, pre-tax $ 175 $ 104 $ 87
Weighted-average period over which cost is expected to be recognized (years) 1 year 9 months 18 days 1 year 9 months 18 days 1 year 9 months 18 days
Performance Share Awards [Member]      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]      
Total fair value of shares vested [1] $ 33 $ 25 $ 64
Compensation cost recognized, pre-tax [2] 76 31 28
Total compensation cost related to nonvested awards not yet recognized, pre-tax $ 54 $ 32 $ 34
Weighted-average period over which cost is expected to be recognized (years) 1 year 9 months 18 days 1 year 10 months 24 days 1 year 9 months 18 days
Share-based Payment Arrangement, Option [Member]      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]      
Total fair value of shares vested (in dollars per share) [1] $ 4.86 $ 3.56 $ 5.98
Aggregate intrinsic value on exercise $ 584 $ 293 $ 261
Cash received upon exercise 795 425 394
Tax benefits realized from exercise 106 55 47
Compensation cost recognized, pre-tax [2] 5 6 7
Total compensation cost related to nonvested awards not yet recognized, pre-tax $ 3 $ 4 $ 5
Weighted-average period over which cost is expected to be recognized (years) 1 year 7 months 6 days 1 year 8 months 12 days 1 year 7 months 6 days
[1] Weighted-average GDFV per TSRUs and stock options.
[2] TSRU includes expense for PTSRUs, which is not significant for all years presented
v3.22.0.1
Share-Based Payments - Schedule of Valuation Assumptions (Detail)
 12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Total Shareholder Return Units (TSRUs) [Member]      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]      
Expected dividend yield 4.51% 4.36% 3.27%
Risk-free interest rate 0.93% 1.15% 2.55%
Expected stock price volatility 26.53% 20.99% 18.34%
Contractual term/expected term 5 years 1 month 24 days 5 years 1 month 13 days 5 years 1 month 17 days
Share-based Payment Arrangement, Option [Member]      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]      
Expected dividend yield 4.51% 4.36% 3.27%
Risk-free interest rate 1.27% 1.25% 2.66%
Expected stock price volatility 26.54% 20.97% 18.34%
Contractual term/expected term 6 years 9 months 6 years 9 months 6 years 9 months
v3.22.0.1
Share-Based Payments - Schedule of Share-based Payment Arrangement Activity (Detail) - $ / shares
shares in Thousands
 12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Weighted Avg. Intrinsic Value per share      
Vested and expected to vest, end of period, shares [1] 44,747    
Total Shareholder Return Units (TSRUs) [Member]      
Number of Shares      
Nonvested, beginning of period, shares 129,844    
Granted, shares 34,522    
Vested, shares (44,888)    
Forfeited, shares (4,879)    
Nonvested, end of period, shares 114,599 129,844  
Weighted Avg. GDFV per share      
Nonvested, beginning of period, weighted-average grant date fair value per share (in dollars per share) $ 6.90    
Granted, weighted-average grant-date fair value per share (in dollars per share) [2] 7.26 $ 6.22 $ 8.52
Vested, weighted-average grant-date fair value per share (in dollars per share) 7.21    
Forfeited, weighted-average grant date fair value per share (in dollars per share) 6.77    
Nonvested, end of period, weighted-average grant date fair value per share (in dollars per share) 6.90 6.90  
Grant Price      
Nonvested, beginning of period, grant price (in dollars per share) 32.94    
Granted, grant price (in dollars per share) 33.83    
Vested, grant price (in dollars per share) 30.54    
Forfeited, grant price (in dollars per share) 33.78    
Nonvested, end of period, grant price (in dollars per share) $ 34.12 $ 32.94  
Restricted Stock Units [Member]      
Number of Shares      
Nonvested, beginning of period, shares 23,692    
Granted, shares 10,893    
Vested, shares (8,747)    
Reinvested dividend equivalents, shares 956    
Forfeited, shares (1,255)    
Nonvested, end of period, shares 25,540 23,692  
Weighted Avg. GDFV per share      
Nonvested, beginning of period, weighted-average grant date fair value per share (in dollars per share) $ 35.50    
Granted, weighted-average grant-date fair value per share (in dollars per share) 34.31    
Vested, weighted-average grant-date fair value per share (in dollars per share) 34.66    
Reinvested dividend equivalents, weighted-average grant date fair value per share (in dollars per share) 41.33    
Forfeited, weighted-average grant date fair value per share (in dollars per share) 35.17    
Nonvested, end of period, weighted-average grant date fair value per share (in dollars per share) $ 35.52 $ 35.50  
Portfolio Performance Shares [Member]      
Number of Shares      
Nonvested, beginning of period, shares [3] 20,077    
Granted, shares [3] 8,632    
Vested, shares [3] (6,095)    
Forfeited, shares [3] (1,133)    
Nonvested, end of period, shares [3] 21,480 20,077  
Weighted Avg. Intrinsic Value per share      
Nonvested, beginning of period, weighted-average intrinsic value per share (in dollars per share) [3] $ 36.81    
Granted, weighted-average intrinsic value per share (in dollars per share) [3] 33.82    
Vested, weighted-average intrinsic value per share (in dollars per share) [3] 33.88    
Forfeited, weighted-average intrinsic value per share (in dollars per share) [3] 41.45    
Nonvested, end of period, weighted-average intrinsic value per share (in dollars per share) [3] $ 59.05 $ 36.81  
Vested and expected to vest, end of period, shares 34,100    
Performance Share Awards [Member]      
Number of Shares      
Nonvested, beginning of period, shares 5,264    
Granted, shares 1,798    
Vested, shares (984)    
Forfeited, shares (924)    
Nonvested, end of period, shares 5,154 5,264  
Weighted Avg. Intrinsic Value per share      
Nonvested, beginning of period, weighted-average intrinsic value per share (in dollars per share) $ 36.81    
Granted, weighted-average intrinsic value per share (in dollars per share) 33.82    
Vested, weighted-average intrinsic value per share (in dollars per share) 33.85    
Forfeited, weighted-average intrinsic value per share (in dollars per share) 34.43    
Nonvested, end of period, weighted-average intrinsic value per share (in dollars per share) $ 59.05 $ 36.81  
Breakthrough Performance Awards (BPAs) [Member]      
Number of Shares      
Nonvested, beginning of period, shares 0    
Granted, shares 1,165    
Vested, shares 0    
Forfeited, shares (306)    
Nonvested, end of period, shares 859 0  
Weighted Avg. Intrinsic Value per share      
Nonvested, beginning of period, weighted-average intrinsic value per share (in dollars per share) $ 0    
Granted, weighted-average intrinsic value per share (in dollars per share) 38.73    
Vested, weighted-average intrinsic value per share (in dollars per share) 0    
Forfeited, weighted-average intrinsic value per share (in dollars per share) 47.47    
Nonvested, end of period, weighted-average intrinsic value per share (in dollars per share) $ 59.05 $ 0  
[1] The number of options expected to vest takes into account an estimate of expected forfeitures.
[2] Weighted-average GDFV per TSRUs and stock options.
[3] Vested and non-vested shares outstanding, but not paid as of December 31, 2021 were 34.1 million.
v3.22.0.1
Share-Based Payments - Summary of TSRU and PTU Information (Details)
$ / shares in Units, $ in Millions
 12 Months Ended
Dec. 31, 2021
USD ($)
$ / shares
shares
Total Shareholder Return Units (TSRUs) [Member]  
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]  
Units outstanding, shares 206,996,000 [1],[2]
Units vested, shares 92,398,000 [1],[2]
Units expected to vest, shares 110,476,000 [1],[2],[3]
Units outstanding, weighted average grant price (in dollars per share) | $ / shares $ 31.71 [1],[2]
Units vested, weighted average grant price (in dollars per share) | $ / shares 28.72 [1],[2]
Units expected to vest, weighted average grant price (in dollars per share) | $ / shares $ 34.16 [1],[2],[3]
Units outstanding, weighted average remaining contractual term 2 years 2 months 12 days [1],[2]
Units vested, weighted average remaining contractual term 9 months 18 days [1],[2]
Units expected to vest, weighted average remaining contractual term 3 years 3 months 18 days [1],[2],[3]
Units outstanding, aggregate intrinsic value | $ $ 5,969 [1],[2]
Units vested, aggregate intrinsic value | $ 2,946 [1],[2]
Units expected to vest, aggregate intrinsic value | $ $ 2,910 [1],[2],[3]
Units settled, shares 46,060,346
Units settled, weighted average grant price (in dollars per share) | $ / shares $ 23.04
Units exercised, shares 7,093,787
Units exercised, weighted average grant price (in dollars per share) | $ / shares $ 27.41
Profit Units [Member]  
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]  
Units exercised and converted, shares 3,074,000 [1],[2]
Units exercised and converted, weighted average remaining contractual term 9 months 18 days [1],[2]
Units exercised and converted, aggregate intrinsic value | $ $ 182 [1],[2]
Units granted upon conversion, shares 2,943,737
[1] In 2021, 7,093,787 TSRUs with a weighted-average grant price of $27.41 per unit were converted into 2,943,737 PTUs.
[2] In 2021, we settled 46,060,346 TSRUs with a weighted-average grant price of $23.04 per unit.
[3] The number of TSRUs expected to vest takes into account an estimate of expected forfeitures.
v3.22.0.1
Share-Based Payments - Schedule of Share-based Compensation, Stock Options, Activity (Detail)
$ / shares in Units, shares in Thousands, $ in Millions
 12 Months Ended
Dec. 31, 2021
USD ($)
$ / shares
shares
Shares (Thousands)  
Outstanding, beginning of period, shares | shares 75,402
Granted, shares | shares 779
Exercised, shares | shares (31,036)
Forfeited, shares | shares (89)
Expired, shares | shares (181)
Outstanding, end of period, shares | shares 44,874
Vested and expected to vest, end of period, shares | shares 44,747 [1]
Exercisable, end of period, shares | shares 41,583
Weighted-Average Exercise Price Per Share  
Outstanding, beginning of period, weighted-average exercise price per share (in dollars per share) | $ / shares $ 28.31
Granted, weighted-average exercise price per share (in dollars per share) | $ / shares 33.82
Exercised, weighted-average exercise price per share (in dollars per share) | $ / shares 25.75
Forfeited, weighted-average exercise price per share (in dollars per share) | $ / shares 34.39
Expired, weighted-average exercise price per share (in dollars per share) | $ / shares 20.27
Outstanding, end of period, weighted-average exercise price per share (in dollars per share) | $ / shares 30.20
Vested and expected to vest, end of period, weighted-average exercise price per share (in dollars per share) | $ / shares 30.19 [1]
Exercisable, end of period, weighted-average exercise price per share (in dollars per share) | $ / shares $ 29.81
Outstanding, end of period, weighted-average remaining contractual term 2 years 8 months 12 days
Vested and expected to vest, end of period, weighted-average remaining contractual term 2 years 8 months 12 days [1]
Exercisable, end of period, weighted-average remaining contractual term 2 years 3 months 18 days
Outstanding, end of period, aggregate intrinsic value | $ $ 1,295 [2]
Vested and expected to vest, end of period, aggregate intrinsic value | $ 1,291 [1],[2]
Exercisable, end of period, aggregate intrinsic value | $ $ 1,216 [2]
[1] The number of options expected to vest takes into account an estimate of expected forfeitures.
[2] Market price of our underlying common stock less exercise price.
v3.22.0.1
Earnings Per Common Share Attributable to Pfizer Inc. Common Shareholders (Details) - USD ($)
shares in Millions, $ in Millions
 12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
EPS Numerator-Basic      
Income from continuing operations attributable to Pfizer Inc. $ 22,414 $ 6,630 $ 10,708
Less: Preferred stock dividends––net of tax 0 0 1
Income from continuing operations attributable to Pfizer Inc. common shareholders 22,414 6,630 10,708
Discontinued operations––net of tax (434) 2,529 5,318
Net income attributable to Pfizer Inc. common shareholders 21,979 9,159 16,025
EPS Numerator––Diluted      
Income from continuing operations attributable to Pfizer Inc. common shareholders and assumed conversions 22,414 6,630 10,708
Discontinued operations––net of tax, attributable to Pfizer Inc. common shareholders and assumed conversions (434) 2,529 5,318
Net income attributable to Pfizer Inc. common shareholders and assumed conversions $ 21,979 $ 9,159 $ 16,026
EPS Denominator      
Weighted-average number of common shares outstanding––Basic 5,601 5,555 5,569
Common-share equivalents: stock options, stock issuable under employee compensation plans convertible preferred stock and accelerated share repurchase agreements (in shares) 107 77 106
Weighted-average number of common shares outstanding––Diluted 5,708 5,632 5,675
Anti-dilutive common stock equivalents (in shares) [1] 2 4 2
[1] These common stock equivalents were outstanding for the periods presented, but were not included in the computation of diluted EPS for those periods because their inclusion would have had an anti-dilutive effect.
v3.22.0.1
Leases - Narrative (Details) - USD ($)
$ in Millions
 12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Lessee, Lease, Description [Line Items]      
Variable lease cost $ 381 $ 380 $ 326
Minimum [Member]      
Lessee, Lease, Description [Line Items]      
Operating lease term 1 year    
Operating lease term, option to extend 5 years    
Maximum [Member]      
Lessee, Lease, Description [Line Items]      
Operating lease term 30 years    
Operating lease term, option to extend 10 years    
v3.22.0.1
Leases - Schedule of Lease Assets and Liabilities (Details) - USD ($)
$ in Millions
Dec. 31, 2021
Dec. 31, 2020
Leases [Abstract]    
ROU assets $ 2,839 $ 1,386
Lease liabilities (short-term) 449 320
Lease liabilities (long-term) $ 2,510 $ 1,108
ROU assets, statement of financial position Other noncurrent assets Other noncurrent assets
Lease liabilities (short-term), statement of financial position Other current liabilities Other current liabilities
Lease liabilities (long-term), statement of financial position Other noncurrent liabilities Other noncurrent liabilities
v3.22.0.1
Leases - Schedule of Lease Costs and Other Supplemental Information (Details) - USD ($)
$ in Millions
 12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Leases [Abstract]      
Operating lease cost $ 548 $ 432 $ 421
Variable lease cost 381 380 326
Sublease income (41) (40) (45)
Total lease cost $ 888 $ 772 702
Weighted-Average Remaining Contractual Lease Term (Years) 12 years 6 years 10 months 24 days  
Weighted-Average Discount Rate 2.80% 2.90%  
Operating cash flows from operating leases $ 387 $ 333 338
(Gains)/losses on sale and leaseback transactions, net $ 1 $ (3) $ (29)
v3.22.0.1
Leases - Schedule of Future Minimum Rental Payments for Operating Leases (Detail) - USD ($)
$ in Millions
Dec. 31, 2021
Dec. 31, 2020
Leases [Abstract]    
Next one year [1] $ 520  
1-2 years 417  
2-3 years 322  
3-4 years 279  
4-5 years 217  
Thereafter 1,865  
Total undiscounted lease payments 3,621  
Less: Imputed interest 661  
Present value of minimum lease payments 2,960  
Less: Current portion 449 $ 320
Noncurrent portion $ 2,510 $ 1,108
[1] Reflects lease payments due within 12 months subsequent to the balance sheet date.
v3.22.0.1
Contingencies and Certain Commitments (Patent Litigation) (Details)
$ in Millions
 12 Months Ended
Dec. 31, 2021
USD ($)
patent
Dec. 31, 2017
defendant
patent
Gain Contingencies [Line Items]    
Threshold for disclosure of proceedings under environmental laws | $ $ 1  
Patent Infringement [Member]    
Gain Contingencies [Line Items]    
Number of patents without court proceedings   2
Pneumococcal Vaccine Patent Infringement [Member]    
Gain Contingencies [Line Items]    
Number of patents allegedly infringed upon 2  
Other Patent Infringement [Member]    
Gain Contingencies [Line Items]    
Number of patents allegedly infringed upon 1  
Eliquis [Member] | Pfizer and BMS Versus Several Generic Manufacturers [Member] | Patent Infringement [Member] | Pending Litigation [Member]    
Gain Contingencies [Line Items]    
Number of patents allegedly infringed upon   3
Number of defendants | defendant   25
Number of patents allegedly infringed upon due to expire in December 2019   1
v3.22.0.1
Contingencies and Certain Commitments (Product Litigation, Commercial and Other Matters, Resolved Matters) (Details)
$ in Millions
 1 Months Ended 12 Months Ended
Sep. 30, 2021
lagoon
Jul. 31, 2021
USD ($)
Dec. 31, 2021
USD ($)
Dec. 31, 2020
USD ($)
Dec. 31, 2019
USD ($)
Dec. 31, 2018
lagoon
manufacturer
Dec. 31, 2013
lagoon
Loss Contingencies [Line Items]              
Loss on litigation settlement [1]     $ 182 $ 28 $ 292    
Epi Pen [Member] | Discontinued Operations, Disposed of by Sale [Member] | Meridian [Member]              
Loss Contingencies [Line Items]              
Loss on litigation settlement   $ 345 $ 345        
Pfizer And Hospira And Various Other Manufacturers Versus Mississippi Attorney General [Member] | Docetaxel [Member] | Pending Litigation [Member]              
Loss Contingencies [Line Items]              
Number of defendants other than main defendant | manufacturer           8  
Environmental Remediation Litigation [Member]              
Loss Contingencies [Line Items]              
Feasibility study, number of lagoons | lagoon 2         2 2
[1] Includes legal reserves for certain pending legal matters.
v3.22.0.1
Contingencies and Certain Commitments (Certain Commitments and Contingent Consideration for Acquisitions) (Details) - USD ($)
$ in Millions
 12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Commitments and Contingencies Disclosure [Abstract]    
Long-term purchase commitment, amount $ 5,200  
Fair value of contingent consideration 697 $ 689
Contingent consideration liability, current 135 123
Contingent consideration liability, noncurrent $ 563 $ 566
v3.22.0.1
Segment, Geographic and Other Revenue Information - Narrative (Detail)
$ in Millions
 12 Months Ended
Dec. 31, 2021
USD ($)
country
operatingSegment
Dec. 31, 2020
USD ($)
country
Dec. 31, 2019
country
Segment Reporting Information [Line Items]      
Number of operating segments | operatingSegment 2    
Total assets $ 181,476 $ 154,229  
Remaining performance obligation 34,400    
Deferred revenues, current 3,067 1,113  
Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Start Date [Axis]: 2022-01-01      
Segment Reporting Information [Line Items]      
Remaining performance obligation $ 22,300    
Remaining performance obligation, period of recognition 1 year    
Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Start Date [Axis]: 2023-01-01      
Segment Reporting Information [Line Items]      
Remaining performance obligation $ 11,800    
Remaining performance obligation, period of recognition 1 year    
Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Start Date [Axis]: 2024-01-01      
Segment Reporting Information [Line Items]      
Remaining performance obligation $ 265    
Remaining performance obligation, period of recognition 1 year    
Government and Government Sponsored [Member] | Comirnaty direct sales and alliance revenues [Member]      
Segment Reporting Information [Line Items]      
Deferred revenues $ 3,300 957  
Deferred revenues, current 3,000 $ 957  
Deferred revenues, noncurrent $ 249    
Geographic Concentration Risk [Member] | Revenue [Member] | Outside United States [Member]      
Segment Reporting Information [Line Items]      
Number of countries with revenue exceeding $500 million | country 21 8 10
Geographic Concentration Risk [Member] | Revenue [Member] | US [Member]      
Segment Reporting Information [Line Items]      
Percentage of total revenues 10.00% 10.00% 10.00%
Geographic Concentration Risk [Member] | Revenue [Member] | Japan [Member]      
Segment Reporting Information [Line Items]      
Percentage of total revenues 9.00% 6.00% 6.00%
Customer Concentration Risk [Member] | Revenue [Member] | Government and Government Sponsored [Member] | Comirnaty direct sales and alliance revenues [Member]      
Segment Reporting Information [Line Items]      
Percentage of total revenues 13.00%    
Customer Concentration Risk [Member] | Accounts Receivable [Member] | Three Largest U.S. Wholesaler Customers [Member]      
Segment Reporting Information [Line Items]      
Percentage of total revenues 24.00% 30.00% 25.00%
Credit Concentration Risk | Accounts Receivable [Member] | Government and Government Sponsored [Member] | Comirnaty direct sales and alliance revenues [Member]      
Segment Reporting Information [Line Items]      
Percentage of total revenues 12.00%    
v3.22.0.1
Segment, Geographic and Other Revenue Information - Schedule of Segment Reporting Information by Segment (Details) - USD ($)
$ in Millions
 3 Months Ended 12 Months Ended
Nov. 17, 2021
Sep. 29, 2019
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Segment Reporting Information [Line Items]          
Revenues [1]     $ 81,288 $ 41,651 $ 40,905
Income from continuing operations before provision/(benefit) for taxes on income [2],[3],[4]     24,311 7,036 11,321
Depreciation and Amortization [5]     5,191 4,681 5,755
Restructuring charges/(credits) and implementation costs and additional depreciation, asset restructuring     1,300 791  
Net periodic benefit, actuarial valuation and other pension and postretirement plan gains     1,600 (1,100) 750
Net (gains)/losses recognized during the period on equity securities [6],[7]     1,344 540 454
Intangible asset impairments       1,700 2,800
Gain on completion of transaction     0 6 8,107
Selling, General and Administrative Expenses [Member]          
Segment Reporting Information [Line Items]          
Restructuring charges/(credits) and implementation costs and additional depreciation, asset restructuring     450 197  
Research and Development Expense [Member]          
Segment Reporting Information [Line Items]          
Payment for collaborative and licensing arrangements     1,100    
Trillium [Member]          
Segment Reporting Information [Line Items]          
Charge to research and development expenses in connection with asset acquisition $ 2,100   2,100    
ViiV [Member]          
Segment Reporting Information [Line Items]          
Dividend income     166 278 220
Consumer Healthcare JV [Member]          
Segment Reporting Information [Line Items]          
Gain on completion of transaction   $ 8,100     8,100
Other Business Activities [Member]          
Segment Reporting Information [Line Items]          
Revenues [8]     1,731 926 2,892
Income from continuing operations before provision/(benefit) for taxes on income [2],[8]     (10,396) (12,308) (11,216)
Depreciation and Amortization [5],[8]     598 603 592
Reconciling Items [Member] | Purchase Accounting Adjustments [Member]          
Segment Reporting Information [Line Items]          
Revenues     0 0 0
Income from continuing operations before provision/(benefit) for taxes on income [2]     (3,175) (3,117) (4,153)
Depreciation and Amortization [5]     3,067 3,047 4,145
Reconciling Items [Member] | Acquisition Related Costs [Member]          
Segment Reporting Information [Line Items]          
Revenues     0 0 0
Income from continuing operations before provision/(benefit) for taxes on income [2]     (52) (44) (185)
Depreciation and Amortization [5]     0 0 3
Reconciling Items [Member] | Other Reconciling Items [Member]          
Segment Reporting Information [Line Items]          
Revenues [9]     0 0 0
Income from continuing operations before provision/(benefit) for taxes on income [2],[9]     (2,292) (4,584) 2,456
Depreciation and Amortization [5],[9]     87 18 37
Biopharma [Member]          
Segment Reporting Information [Line Items]          
Revenues [1],[10]     79,557 40,724 38,013
Biopharma [Member] | Operating Segments [Member]          
Segment Reporting Information [Line Items]          
Revenues     79,557 40,724 38,013
Income from continuing operations before provision/(benefit) for taxes on income [2]     40,226 27,089 24,419
Depreciation and Amortization [5]     $ 1,439 $ 1,013 $ 978
[1] On December 31, 2021, we completed the sale of our Meridian subsidiary. Prior to its sale, Meridian was managed as part of the Hospital therapeutic area. On November 16, 2020, we completed the spin-off and the combination of our Upjohn Business with Mylan to form Viatris. On December 21, 2020, Pfizer and Viatris completed the termination of the Mylan-Japan collaboration. Beginning in the fourth quarter of 2021, the financial results of Meridian are reflected as discontinued operations for all periods presented. Beginning in the fourth quarter of 2020, the financial results of the Upjohn Business and Mylan-Japan collaboration were reflected as discontinued operations for all periods presented. Prior-period financial information has been restated, as appropriate. See Note 1A.
[2] Income from continuing operations before provision/(benefit) for taxes on income. Biopharma’s earnings include dividend income from our investment in ViiV of $166 million in 2021, $278 million in 2020 and $220 million in 2019.
[3] 2020 v. 2019––The domestic loss in 2020 versus domestic income in 2019 was mainly related to the non-recurrence of the gain on the completion of the Consumer Healthcare JV transaction as well as higher asset impairment charges and higher R&D expenses. The increase in the international income was primarily related to the non-recurrence of the write off of assets contributed to the Consumer Healthcare JV as well as lower asset impairment charges and lower amortization of intangible assets.
[4] 2021 v. 2020––The domestic income in 2021 versus domestic loss in 2020 was mainly related to Comirnaty income, lower asset impairment charges, net periodic benefit credits in 2021 versus net periodic benefit costs in 2020 and higher net gains from equity securities, partially offset by higher R&D expenses. The increase in the international income was primarily related to Comirnaty income, net periodic benefit credits in 2021 versus net periodic benefit costs in 2020 and lower asset impairment charges.
[5] Certain production facilities are shared. Depreciation is allocated based on estimates of physical production. Amounts here relate solely to the depreciation and amortization associated with continuing operations.
[6] Reported in Other (income)/deductions––net. See Note 4.
[7] (b)2021 gains include, among other things, unrealized gains of $1.6 billion related to investments in BioNTech and Cerevel. 2020 gains included, among other things, unrealized gains of $405 million related to investments in BioNTech and SpringWorks Therapeutics, Inc. (SpringWorks). 2019 gains included, among other things, unrealized gains of $295 million related to investments in Cortexyme, Inc. and SpringWorks.
[8] Other business activities include revenues and costs associated with PC1, as well as costs associated with global WRDM and GPD platform functions, global corporate enabling functions and other corporate items, as noted above, that we do not allocate to our operating segments. In 2019, Other business activities also include revenues and costs associated with our former Consumer Healthcare business through July 31, 2019. See Note 2C.
[9] Certain significant items are substantive and/or unusual, and in some cases recurring, items (as noted above) that, either as a result of their nature or size, would not be expected to occur as part of our normal business on a regular basis. For Earnings in 2021, includes, among other items: (i) a $2.1 billion charge for IPR&D related to our acquisition of Trillium, which was accounted for as an asset acquisition and recorded in Research and development expenses, (ii) restructuring charges/(credits) and implementation costs and additional depreciation—asset restructuring of $1.3 billion ($450 million recorded in Selling, informational and administrative expenses and the remaining amount primarily recorded in Restructuring charges and certain acquisition-related costs) and (iii) upfront and milestone payments on collaborative and licensing arrangements of $1.1 billion recorded in Research and development expenses, partially offset by (iv) actuarial valuation and other pension and postretirement plan gains of $1.6 billion recorded in Other (income)/deductions––net and (v) gains on equity securities of $1.3 billion recorded in Other (income)/deductions––net. For Earnings in 2020, includes, among other items; (i) charges of $1.7 billion related to certain asset impairments recorded in Other (income)/deductions––net, (ii) actuarial valuation and other pension and postretirement plan losses of $1.1 billion recorded in Other (income)/deductions––net and (iii) restructuring charges/(credits) and implementation costs and additional depreciation—asset restructuring of $791 million ($197 million recorded in Selling, informational and administrative expenses and the remaining amount primarily recorded in Restructuring charges and certain acquisition-related costs). For Earnings in 2019, includes, among other items: (i) a pre-tax gain of $8.1 billion recorded in (Gain) on completion of Consumer Healthcare JV transaction associated with the completion of the Consumer Healthcare JV transaction, partially offset by (ii) charges of $2.8 billion related to certain asset impairments recorded in Other (income)/deductions––net and (iii) actuarial valuation and other pension and postretirement plan losses of $750 million recorded in Other (income)/deductions––net. For additional information, see Notes 2A, 2C, 3 and 4
[10] At the beginning of our fiscal fourth quarter of 2021, we reorganized our commercial operations and began to manage our commercial operations through a new global structure consisting of two operating segments, each led by a single manager: Biopharma, our innovative science-based biopharmaceutical business and PC1. PC1, which previously had been managed within the Hospital therapeutic area, includes revenues from our contract manufacturing, including certain Comirnaty-related manufacturing activities performed on behalf of BioNTech ($320 million for 2021 and $0 million for 2020 and 2019), and active pharmaceutical ingredient sales operation, as well as revenues related to our manufacturing and supply agreements with former legacy Pfizer businesses/partnerships, including but not limited to, transitional manufacturing and supply agreements with Viatris following the spin-off of the Upjohn Business. We have revised prior period information to conform to the current management structure.
v3.22.0.1
Segment, Geographic and Other Revenue Information - Revenues By Geographic Area (Detail) - USD ($)
$ in Millions
 12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Revenues from External Customers and Long-Lived Assets [Line Items]      
Revenues [1] $ 81,288 $ 41,651 $ 40,905
US [Member]      
Revenues from External Customers and Long-Lived Assets [Line Items]      
Revenues 29,746 21,455 20,326
Developed Europe [Member]      
Revenues from External Customers and Long-Lived Assets [Line Items]      
Revenues 18,336 7,788 7,729
Developed Rest Of World [Member]      
Revenues from External Customers and Long-Lived Assets [Line Items]      
Revenues 12,506 4,036 4,022
Emerging Markets [Member]      
Revenues from External Customers and Long-Lived Assets [Line Items]      
Revenues $ 20,701 $ 8,372 $ 8,828
[1] On December 31, 2021, we completed the sale of our Meridian subsidiary. Prior to its sale, Meridian was managed as part of the Hospital therapeutic area. On November 16, 2020, we completed the spin-off and the combination of our Upjohn Business with Mylan to form Viatris. On December 21, 2020, Pfizer and Viatris completed the termination of the Mylan-Japan collaboration. Beginning in the fourth quarter of 2021, the financial results of Meridian are reflected as discontinued operations for all periods presented. Beginning in the fourth quarter of 2020, the financial results of the Upjohn Business and Mylan-Japan collaboration were reflected as discontinued operations for all periods presented. Prior-period financial information has been restated, as appropriate. See Note 1A.
v3.22.0.1
Segment, Geographic and Other Revenue Information - Schedules of Concentration of Risk (Details) - Revenue [Member] - Customer Concentration Risk [Member]
 12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
McKesson, Inc. [Member]      
Concentration Risk [Line Items]      
Percentage of total revenues 9.00% 16.00% 15.00%
AmerisourceBergen Corporation [Member]      
Concentration Risk [Line Items]      
Percentage of total revenues 7.00% 14.00% 11.00%
Cardinal Health, Inc. [Member]      
Concentration Risk [Line Items]      
Percentage of total revenues 5.00% 10.00% 9.00%
v3.22.0.1
Segment, Geographic and Other Revenue Information - Revenues By Products (Detail) - USD ($)
$ in Millions
 12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Revenue from External Customer [Line Items]      
Revenues [1] $ 81,288 $ 41,651 $ 40,905
Biopharma [Member]      
Revenue from External Customer [Line Items]      
Revenues [1],[2] 79,557 40,724 38,013
Pfizer CentreOne [Member]      
Revenue from External Customer [Line Items]      
Revenues [2] 1,731 926 810
BioNTech [Member] | Pfizer CentreOne [Member]      
Revenue from External Customer [Line Items]      
Revenues 320 0 0
Alliance Biopharmaceuticals [Member]      
Revenue from External Customer [Line Items]      
Revenues 7,652 5,418 4,648
Total Biosimilars [Member]      
Revenue from External Customer [Line Items]      
Revenues [3] 2,343 1,527 911
Total Sterile Injectable Pharmaceuticals [Member]      
Revenue from External Customer [Line Items]      
Revenues [4] 5,746 5,315 5,013
Vaccines [Member] | Biopharma [Member]      
Revenue from External Customer [Line Items]      
Revenues 42,625 6,575 6,504
Vaccines [Member] | Comirnaty direct sales and alliance revenues [Member] | Biopharma [Member]      
Revenue from External Customer [Line Items]      
Revenues 36,781 154 0
Vaccines [Member] | Prevenar 13/Prevnar 13 [Member] | Biopharma [Member]      
Revenue from External Customer [Line Items]      
Revenues [5] 5,272 5,850 5,847
Vaccines [Member] | Nimenrix [Member] | Biopharma [Member]      
Revenue from External Customer [Line Items]      
Revenues 193 221 230
Vaccines [Member] | FSME/IMMUN-TicoVac [Member] | Biopharma [Member]      
Revenue from External Customer [Line Items]      
Revenues 185 196 220
Vaccines [Member] | Trumenba [Member] | Biopharma [Member]      
Revenue from External Customer [Line Items]      
Revenues 118 112 135
Vaccines [Member] | Other Vaccines Products [Member] | Biopharma [Member]      
Revenue from External Customer [Line Items]      
Revenues 74 42 73
Oncology [Member] | Biopharma [Member]      
Revenue from External Customer [Line Items]      
Revenues 12,333 10,867 9,014
Oncology [Member] | Ibrance [Member] | Biopharma [Member]      
Revenue from External Customer [Line Items]      
Revenues 5,437 5,392 4,961
Oncology [Member] | Xtandi Alliance Revenues [Member] | Biopharma [Member]      
Revenue from External Customer [Line Items]      
Revenues 1,185 1,024 838
Oncology [Member] | Inlyta [Member] | Biopharma [Member]      
Revenue from External Customer [Line Items]      
Revenues 1,002 787 477
Oncology [Member] | Sutent [Member] | Biopharma [Member]      
Revenue from External Customer [Line Items]      
Revenues 673 819 936
Oncology [Member] | Bosulif [Member] | Biopharma [Member]      
Revenue from External Customer [Line Items]      
Revenues 540 450 365
Oncology [Member] | Xalkori [Member] | Biopharma [Member]      
Revenue from External Customer [Line Items]      
Revenues 493 544 530
Oncology [Member] | Ruxience [Member] | Biopharma [Member]      
Revenue from External Customer [Line Items]      
Revenues [3] 491 170 (1)
Oncology [Member] | Retacrit [Member] | Biopharma [Member]      
Revenue from External Customer [Line Items]      
Revenues [3] 444 386 225
Oncology [Member] | Zirabev [Member] | Biopharma [Member]      
Revenue from External Customer [Line Items]      
Revenues [3] 444 143 1
Oncology [Member] | Lorbrena [Member] | Biopharma [Member]      
Revenue from External Customer [Line Items]      
Revenues 266 204 115
Oncology [Member] | Aromasin [Member] | Biopharma [Member]      
Revenue from External Customer [Line Items]      
Revenues 211 148 136
Oncology [Member] | Trazimera [Member] | Biopharma [Member]      
Revenue from External Customer [Line Items]      
Revenues [3] 197 98 6
Oncology [Member] | Besponsa [Member] | Biopharma [Member]      
Revenue from External Customer [Line Items]      
Revenues 192 182 157
Oncology [Member] | Braftovi [Member] | Biopharma [Member]      
Revenue from External Customer [Line Items]      
Revenues 187 160 48
Oncology [Member] | Bavencio Alliance Revenues [Member] | Biopharma [Member]      
Revenue from External Customer [Line Items]      
Revenues 178 80 49
Oncology [Member] | Mektovi [Member] | Biopharma [Member]      
Revenue from External Customer [Line Items]      
Revenues 155 142 49
Oncology [Member] | Other Oncology Products [Member] | Biopharma [Member]      
Revenue from External Customer [Line Items]      
Revenues 238 137 122
Internal Medicine [Member] | Biopharma [Member]      
Revenue from External Customer [Line Items]      
Revenues 9,329 9,003 8,790
Internal Medicine [Member] | Eliquis [Member] | Biopharma [Member]      
Revenue from External Customer [Line Items]      
Revenues 5,970 4,949 4,220
Internal Medicine [Member] | Premarin Family [Member] | Biopharma [Member]      
Revenue from External Customer [Line Items]      
Revenues 563 680 734
Internal Medicine [Member] | Chantix Champix [Member] | Biopharma [Member]      
Revenue from External Customer [Line Items]      
Revenues 398 919 1,107
Internal Medicine [Member] | BMP2 [Member] | Biopharma [Member]      
Revenue from External Customer [Line Items]      
Revenues 266 274 287
Internal Medicine [Member] | Toviaz [Member] | Biopharma [Member]      
Revenue from External Customer [Line Items]      
Revenues 238 252 250
Internal Medicine [Member] | Pristiq [Member] | Biopharma [Member]      
Revenue from External Customer [Line Items]      
Revenues 187 171 176
Internal Medicine [Member] | All Other Internal Medicine [Member] | Biopharma [Member]      
Revenue from External Customer [Line Items]      
Revenues 1,706 1,758 2,016
Hospital [Member] | Biopharma [Member]      
Revenue from External Customer [Line Items]      
Revenues [1] 7,301 6,777 6,695
Hospital [Member] | Sulperazon [Member] | Biopharma [Member]      
Revenue from External Customer [Line Items]      
Revenues 683 618 684
Hospital [Member] | Medrol [Member] | Biopharma [Member]      
Revenue from External Customer [Line Items]      
Revenues 432 402 469
Hospital [Member] | Zavicefta [Member] | Biopharma [Member]      
Revenue from External Customer [Line Items]      
Revenues 413 212 108
Hospital [Member] | Fragmin [Member] | Biopharma [Member]      
Revenue from External Customer [Line Items]      
Revenues 305 252 253
Hospital [Member] | Zithromax Zmax [Member] | Biopharma [Member]      
Revenue from External Customer [Line Items]      
Revenues 278 276 336
Hospital [Member] | Vfend [Member] | Biopharma [Member]      
Revenue from External Customer [Line Items]      
Revenues 267 270 346
Hospital [Member] | Tygacil [Member] | Biopharma [Member]      
Revenue from External Customer [Line Items]      
Revenues 200 160 197
Hospital [Member] | Precedex [Member] | Biopharma [Member]      
Revenue from External Customer [Line Items]      
Revenues 177 260 155
Hospital [Member] | Zyvox [Member] | Biopharma [Member]      
Revenue from External Customer [Line Items]      
Revenues 173 222 251
Hospital [Member] | Paxlovid [Member] | Biopharma [Member]      
Revenue from External Customer [Line Items]      
Revenues 76 0 0
Hospital [Member] | IVIg Products [Member] | Biopharma [Member]      
Revenue from External Customer [Line Items]      
Revenues [6] 430 376 275
Hospital [Member] | Other Anti-infectives [Member] | Biopharma [Member]      
Revenue from External Customer [Line Items]      
Revenues 1,453 1,294 1,396
Hospital [Member] | Other Hospital Products [Member] | Biopharma [Member]      
Revenue from External Customer [Line Items]      
Revenues 2,412 2,435 2,225
Inflammation and Immunology [Member] | Biopharma [Member]      
Revenue from External Customer [Line Items]      
Revenues 4,431 4,567 4,733
Inflammation and Immunology [Member] | Xeljanz [Member] | Biopharma [Member]      
Revenue from External Customer [Line Items]      
Revenues 2,455 2,437 2,242
Inflammation and Immunology [Member] | Enbrel [Member] | Biopharma [Member]      
Revenue from External Customer [Line Items]      
Revenues 1,185 1,350 1,699
Inflammation and Immunology [Member] | Inflectra/Remsima [Member] | Biopharma [Member]      
Revenue from External Customer [Line Items]      
Revenues [3] 657 659 625
Inflammation and Immunology [Member] | All Other Inflammation and Immunology Products [Member] | Biopharma [Member]      
Revenue from External Customer [Line Items]      
Revenues 134 121 167
Rare Disease [Member] | Biopharma [Member]      
Revenue from External Customer [Line Items]      
Revenues 3,538 2,936 2,278
Rare Disease [Member] | Vyndaqel/Vyndamax [Member] | Biopharma [Member]      
Revenue from External Customer [Line Items]      
Revenues 2,015 1,288 473
Rare Disease [Member] | BeneFIX [Member] | Biopharma [Member]      
Revenue from External Customer [Line Items]      
Revenues 438 454 488
Rare Disease [Member] | Genotropin [Member] | Biopharma [Member]      
Revenue from External Customer [Line Items]      
Revenues 389 427 498
Rare Disease [Member] | ReFacto AF Xyntha [Member] | Biopharma [Member]      
Revenue from External Customer [Line Items]      
Revenues 304 370 426
Rare Disease [Member] | Somavert [Member] | Biopharma [Member]      
Revenue from External Customer [Line Items]      
Revenues 277 277 264
Rare Disease [Member] | All Other Rare Disease Products [Member] | Biopharma [Member]      
Revenue from External Customer [Line Items]      
Revenues 115 120 129
Consumer Healthcare Reporting Unit [Member]      
Revenue from External Customer [Line Items]      
Revenues [7] $ 0 $ 0 $ 2,082
[1] On December 31, 2021, we completed the sale of our Meridian subsidiary. Prior to its sale, Meridian was managed as part of the Hospital therapeutic area. On November 16, 2020, we completed the spin-off and the combination of our Upjohn Business with Mylan to form Viatris. On December 21, 2020, Pfizer and Viatris completed the termination of the Mylan-Japan collaboration. Beginning in the fourth quarter of 2021, the financial results of Meridian are reflected as discontinued operations for all periods presented. Beginning in the fourth quarter of 2020, the financial results of the Upjohn Business and Mylan-Japan collaboration were reflected as discontinued operations for all periods presented. Prior-period financial information has been restated, as appropriate. See Note 1A.
[2] At the beginning of our fiscal fourth quarter of 2021, we reorganized our commercial operations and began to manage our commercial operations through a new global structure consisting of two operating segments, each led by a single manager: Biopharma, our innovative science-based biopharmaceutical business and PC1. PC1, which previously had been managed within the Hospital therapeutic area, includes revenues from our contract manufacturing, including certain Comirnaty-related manufacturing activities performed on behalf of BioNTech ($320 million for 2021 and $0 million for 2020 and 2019), and active pharmaceutical ingredient sales operation, as well as revenues related to our manufacturing and supply agreements with former legacy Pfizer businesses/partnerships, including but not limited to, transitional manufacturing and supply agreements with Viatris following the spin-off of the Upjohn Business. We have revised prior period information to conform to the current management structure.
[3] Biosimilars are highly similar versions of approved and authorized biological medicines and primarily include revenues from Inflectra/Remsima, Ruxience, Retacrit, Zirabev and Trazimera.
[4] Total Sterile Injectable Pharmaceuticals represents the total of all branded and generic injectable products in the Hospital therapeutic area, including anti-infective sterile injectable pharmaceuticals.
[5] Prevnar family include revenues from Prevnar 13/Prevenar 13 (pediatric and adult) and Prevnar 20 (adult).
[6] Intravenous immunoglobulin (IVIg) products include the revenues from Panzyga, Octagam and Cutaquig.
[7] On July 31, 2019, our Consumer Healthcare business, an OTC medicines business, was combined with GSK’s consumer healthcare business to form a new consumer healthcare JV. See Note 2C.