UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
 
_____________________________
FORM 8-K
_____________________________

CURRENT REPORT
Pursuant to Section 13 OR 15(d) of
The Securities Exchange Act of 1934

Date of Report (Date of earliest event reported): July 28, 2021

_____________________________
BRISTOL-MYERS SQUIBB COMPANY
(Exact name of registrant as specified in its charter)
_____________________________
									
Delaware	001-01136	22-0790350	
(State or other jurisdiction of
incorporation or organization)	(Commission File Number)	(I.R.S Employer
Identification No.)	
430 E. 29th Street, 14th Floor
New York, NY, 10016
(Address of principal executive offices) (zip code)

Registrant’s telephone number, including area code: (212) 546-4000
_____________________________

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions (see General Instruction A.2. below):

☐ Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)

☐ Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)

☐ Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))

☐ Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))

Securities registered pursuant to Section 12(b) of the Act:

Title of each class	Trading Symbol(s)	Name of each exchange on which registered	
Common Stock, $0.10 Par Value	BMY	New York Stock Exchange	
1.000% Notes due 2025	BMY25	New York Stock Exchange	
1.750% Notes due 2035	BMY35	New York Stock Exchange	
Celgene Contingent Value Rights	CELG RT	New York Stock Exchange	

Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (§240.12b-2 of this chapter).

Emerging growth company ☐

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐

			

			
Item 2.02 Results of Operations and Financial Condition.	
On July 28, 2021, Bristol-Myers Squibb Company (the “Company”) issued a press release (the “Earnings Press Release”) announcing its financial results for the second quarter of 2021. A copy of the Earnings Press Release is furnished pursuant to this Item 2.02 as Exhibit 99.1 to this Current Report on Form 8-K and incorporated by reference herein in its entirety. Also furnished pursuant to this Item 2.02 as Exhibit 99.2 to this Current Report on Form 8-K and incorporated by reference herein in its entirety is certain supplemental information (the “Supplemental Information”) posted on the Company’s website at www.bms.com.

Item 7.01 Regulation FD Disclosure.	
On July 28, 2021, the Company posted on its website at www.bms.com a presentation (the “Bristol Myers Presentation”) on certain financial and operating initiatives available for viewing during the Company’s conference call and webcast announcing its financial results for the second quarter of 2021 at 8:00 a.m. Eastern time on July 28, 2021. A copy of the Bristol Myers Presentation is furnished pursuant to this Item 7.01 as Exhibit 99.3 to this Current Report on Form 8-K and incorporated by reference herein in its entirety. The Bristol Myers Presentation includes references to non-GAAP financial information. Reconciliations between the non-GAAP financial measures and the comparable GAAP financial measures are available in the Supplemental Information, which is included as Exhibit 99.2 hereto, and the reasons for the presentation of such non-GAAP financial measures are available in the Earnings Press Release, which is included as Exhibit 99.1 hereto. The Bristol Myers Presentation should be read in conjunction with the Supplemental Information and the Earnings Press Release. The Company reserves the right to discontinue availability of the Bristol Myers Presentation from its website at any time.

Pursuant to General Instruction B.2. to Form 8-K, the information set forth in this Item 7.01 of this Current Report on Form 8-K, including Exhibit 99.3, shall not be deemed “filed” for purposes of Section 18 of the Securities Exchange Act of 1934, as amended, or otherwise subject to the liabilities thereof, nor shall it be incorporated by reference into future filings by the Company under the Exchange Act or under the Securities Act of 1933, as amended, except to the extent specifically provided in any such filing. Additionally, the submission of the information set forth in this Item 7.01 is not deemed an admission as to the materiality of any information in this this Current Report on Form 8-K that is required to be disclosed solely by Regulation FD.

Item 9.01 Financial Statements and Exhibits.	
(d) Exhibits

The following exhibits are furnished as part of this Current Report on Form 8-K:

			
Exhibit
No.		Description	
			
99.1		Press release of Bristol-Myers Squibb Company dated July 28, 2021.	
99.2		Certain supplemental information posted on Bristol-Myers Squibb Company’s website at www.bms.com not included in the press release.	
99.3		Presentation Materials of Bristol-Myers Squibb Company dated July 28, 2021.	
104		The cover page from this Current Report on Form 8-K formatted in Inline XBRL (included as Exhibit 101).	
EXHIBIT INDEX

			
Exhibit
No.	  	Description	
		
99.1		Press release of Bristol-Myers Squibb Company dated July 28, 2021.	
99.2		Certain supplemental information posted on Bristol-Myers Squibb Company’s website at www.bms.com not included in the press release.	
99.3		Presentation Materials of Bristol-Myers Squibb Company dated July 28, 2021.	
104		The cover page from this Current Report on Form 8-K formatted in Inline XBRL (included as Exhibit 101).	

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, as amended, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized. 
																		
	 	BRISTOL-MYERS SQUIBB COMPANY		
				
Dated: July 28, 2021	 	By:	 	/s/ Katherine R. Kelly		
		Name:	 	Katherine R. Kelly		
		Title:		Corporate Secretary		

Exhibit 99.1

Bristol Myers Squibb Reports Second Quarter Financial Results for 2021
•Reports Second Quarter Revenues of $11.7 Billion, an Increase of 16% YoY, or 13% When Adjusted for Foreign Exchange
•Posts Second Quarter Earnings Per Share of $0.47 and Non-GAAP EPS of $1.93
•Delivers Strong Commercial Performance, Including Opdivo’s Return to Growth and Momentum across New Product Portfolio
•Achieves Significant Regulatory and Clinical Milestones across Product Pipeline
•Further Strengthens Pipeline through Disciplined Business Development Agreements, including with Agenus and Eisai
•Adjusts GAAP and Reaffirms Non-GAAP EPS Guidance for 2021

(NEW YORK, July 28, 2021) – Bristol Myers Squibb (NYSE:BMY) today reports results for the second quarter of 2021, which reflect robust product sales, continued advancement of the pipeline and strong clinical and operational performance across the company.

“We delivered a strong quarter across each of our four therapeutic areas, including building momentum for our new product portfolio and Opdivo returning to growth,” said Giovanni Caforio, M.D., board chair and chief executive officer, Bristol Myers Squibb. “We achieved
significant clinical and regulatory milestones reflecting the hard work and dedication of our team, who together have built a portfolio of best-in-class medicines to meet the needs of patients with serious diseases. As we move forward, we remain focused on driving inline product performance, progressing our new launches, and advancing pipeline opportunities. Our robust and diverse pipeline combined with our clinical and commercial execution strengthen our confidence in our ability to renew the portfolio and achieve sustained growth.”
																		
	Second Quarter	
$ amounts in millions, except per share amounts						
	2021		2020		Change	
Total Revenues	$11,703 			$10,129 			16 	%	
Earnings (Loss) Per Share - GAAP	0.47 			(0.04)			N/A	
Earnings Per Share - Non-GAAP	1.93 			1.63 			18 	%	

1

SECOND QUARTER FINANCIAL RESULTS

All comparisons are made versus the same period in 2020 unless otherwise stated.

•Bristol Myers Squibb posted second quarter revenues of $11.7 billion, an increase of 16%, or 13% when adjusted for foreign exchange. Sales in the same period a year ago were negatively impacted by approximately $350 million of COVID-19-related channel inventory work downs.
•U.S. revenues increased 14% to $7.4 billion in the quarter. International revenues increased 18% to $4.3 billion in the quarter. When adjusted for foreign exchange impact, international revenues increased 10%.
•Gross margin increased from 73.4% to 79.0% in the quarter primarily due to lower unwinding of inventory purchase price accounting adjustments, partially offset by foreign exchange.
On a non-GAAP basis, gross margin decreased from 80.5% to 79.8% in the quarter driven by foreign exchange and product mix.
•Marketing, selling and administrative expenses increased 16% to $1.9 billion in the quarter on a GAAP and non-GAAP basis primarily due to higher advertising and promotion expenses, higher costs to support new product launches and lower spending in the prior year due to COVID-19.
•Research and development expenses increased 30% to $3.3 billion in the quarter primarily due to higher license and asset acquisition charges and an in-process research and development (IPR&D) impairment charge.
On a non-GAAP basis, research and development expenses increased 4% to $2.3 billion in the quarter primarily due to higher costs associated with the broader portfolio and lower spending in the prior year due to COVID-19.
•Amortization of acquired intangible assets increased $158 million to $2.5 billion in the quarter.
•The effective tax rate was 31.7% in the quarter. Income taxes were $1.7 billion on pre-tax earnings of $1.6 billion in the same period a year ago primarily due to tax charges resulting from an internal transfer of certain intangible assets and the Otezla® divestiture and purchase price adjustments.
On a non-GAAP basis, the effective tax rate increased 3.1% to 16.9% in the quarter primarily driven by earnings mix.
•The company reported net earnings attributable to Bristol Myers Squibb of $1.1 billion, or $0.47 per share, in the second quarter, compared to net loss of $85 million, or $0.04 per share, for the same period a year ago.
2

•The company reported non-GAAP net earnings attributable to Bristol Myers Squibb of $4.3 billion, or $1.93 per share, in the second quarter, compared to non-GAAP net earnings of $3.8 billion, or $1.63 per share, for the same period a year ago.

A discussion of the non-GAAP financial measures is included under the “Use of Non-GAAP Financial Information” section.

SECOND QUARTER PRODUCT REVENUE HIGHLIGHTS
												
$ amounts in millions				
Product	Quarter Ended
June 30, 2021	Quarter Ended
June 30, 2020	% Change from Quarter Ended June 30, 2020	
Revlimid	$3,202	$2,884	11%	
Eliquis	$2,792	$2,163	29%	
Opdivo	$1,910	$1,653	16%	
Orencia	$814	$750	9%	
Pomalyst/Imnovid	$854	$745	15%	
Sprycel	$541	$511	6%	
Yervoy	$510	$369	38%	
Abraxane	$296	$308	(4)%	
Empliciti	$86	$97	(11)%	
Reblozyl**	$128	$55	*	
Inrebic**	$16	$15	7%	
Onureg**	$12	N/A	N/A	
Zeposia**	$28	$1	*	
Breyanzi**	$17	N/A	N/A	
Abecma**	$24	N/A	N/A	
*    In excess of +100%.
**    Included as part of the new product portfolio

FIRST HALF PRODUCT REVENUE HIGHLIGHTS
												
$ amounts in millions				
Product	Six Months Ended
June 30, 2021	Six Months Ended
June 30, 2020	% Change from Six Months Ended June 30, 2020	
Revlimid	$6,146	$5,799	6%	
Eliquis	$5,678	$4,804	18%	
Opdivo	$3,630	$3,419	6%	
Orencia	$1,572	$1,464	7%	
Pomalyst/Imnovid	$1,627	$1,458	12%	
Sprycel	$1,011	$1,032	(2)%	
Yervoy	$966	$765	26%	

	

	

3

												

	

	

	
Abraxane	$610	$608	—	
Empliciti	$171	$194	(12)%	
Reblozyl**	$240	$63	*	
Inrebic**	$32	$27	19%	
Onureg**	$27	N/A	N/A	
Zeposia**	$46	$1	*	
Breyanzi**	$17	N/A	N/A	
Abecma**	$24	N/A	N/A	
*    In excess of +100%.
**    Included as part of the new product portfolio

SECOND QUARTER PRODUCT AND PIPELINE UPDATE

Cardiovascular

mavacamten

Medical Meeting
•In May, at the American College of Cardiology’s 70th Annual Scientific Session (ACC.21), the company presented:
◦New analysis of data from the Phase 3 EXPLORER-HCM study that demonstrated a Health Status Benefit in patients with obstructive hypertrophic cardiomyopathy (oHCM) receiving mavacamten compared to placebo. The data were simultaneously published in The Lancet. (link)
◦Interim results from MAVA-LTE, an ongoing, dose-blinded five-year extension study of the EXPLORER-HCM Phase 3 trial, which demonstrated that in patients with oHCM, mavacamten was well tolerated and showed durable improvement in left ventricular outflow tract gradients, diastolic function, N-terminal-pro hormone B-type natriuretic peptide and symptoms. (link)
◦Results from a real-world data analysis measuring the clinical and economic burden of oHCM in the United States, which found the condition is associated with substantial healthcare resource utilization and costs. (link)
4

Oncology

Opdivo

Regulatory
•In June, the company announced that the European Commission (EC) has approved Opdivo® (nivolumab) plus Yervoy® (ipilimumab) for the treatment of adult patients with mismatch repair deficient or microsatellite instability-high (dMMR/MSI-H) metastatic colorectal cancer (mCRC) after prior fluoropyrimidine-based combination chemotherapy. The EC approval is based on results from the Phase 2 CheckMate -142 study. (link). In May, the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) recommended approval for this indication (link)
•In June, the company announced that the CHMP of the EMA has recommended approval of Opdivo for the adjuvant treatment of adult patients with esophageal or gastroesophageal junction cancer (GEJC) who have residual pathologic disease following prior neoadjuvant chemoradiotherapy (CRT). The recommendation is based on results from the Phase 3 CheckMate -577 study in which Opdivo doubled disease-free survival compared to placebo in the all-randomized population. (link)
•In June, the company announced that the EC has approved Opdivo plus Yervoy for the first-line treatment of adults with unresectable malignant pleural mesothelioma (MPM). The EC’s decision is based on results from the CheckMate -743 study, the first and only positive Phase 3 study of an immunotherapy in first-line MPM.(link)
•In May, the company announced that the U.S. Food & Drug Administration (FDA) has approved Opdivo for the adjuvant treatment of completely resected esophageal cancer or GEJC with residual pathologic disease in patients who have received neoadjuvant CRT. The FDA approval is based on results from the Phase 3 CheckMate -577 study. (link)
•In April, the company announced that the FDA has accepted the supplemental Biologics License Application for Opdivo for the adjuvant treatment of patients with surgically resected, high-risk muscle-invasive urothelial carcinoma, based on results from the Phase 3 CheckMate -274 study. The FDA granted the application Priority Review and assigned a Prescription Drug User Fee Act goal date of September 3, 2021. (link)
Clinical
•Today, the company announced that the Phase 3 CheckMate -649 trial did not meet the secondary endpoint of overall survival (OS) with the combination of Opdivo plus Yervoy as
5

compared to chemotherapy as a first-line treatment for metastatic gastric cancer (GC), GEJC or esophageal adenocarcinoma (EAC) in patients whose tumors express PD-L1 with a combined positive score (CPS) ≥ 5, at a final analysis. The safety profiles of Opdivo and Yervoy in this trial were consistent with those previously reported for other tumor types. These data have no impact on the U.S. indication for Opdivo plus chemotherapy for the treatment of patients with advanced or metastatic GC, GEJC and EAC, regardless of PD-L1 expression status, which received full approval from the FDA based on results from the CheckMate -649 study.
•In July, the company announced an update on the Phase 3 CheckMate -651 study comparing Opdivo plus Yervoy to the EXTREME regimen (cetuximab, cisplatin/carboplatin and fluorouracil) as a first-line treatment in platinum-eligible patients with recurrent or metastatic squamous cell carcinoma of the head and neck. Although Opdivo plus Yervoy showed a clear, positive trend towards OS in patients whose tumors express PD-L1 with a combined CPS ≥ 20, the study did not meet its primary endpoints. (link)

Medical Meetings
•In May and June, the company announced new data and analyses across its cancer portfolio (link) that were presented at the American Society of Clinical Oncology (ASCO) 2021 Annual Meeting, including results from the:
◦Phase 2/3 RELATIVITY-047 study, which showed that the fixed-dose combination of relatlimab, a LAG-3-blocking antibody, and nivolumab, administered as a single infusion, demonstrated a statistically significant and clinically meaningful progression-free survival benefit compared to Opdivo alone in patients with previously untreated metastatic or unresectable melanoma. (link)
◦Phase 3 CheckMate -648 study, in which two Opdivo-based treatment combinations — Opdivo plus chemotherapy and Opdivo plus Yervoy — demonstrated a statistically significant and clinically meaningful OS benefit compared to chemotherapy at the pre-specified interim analysis in patients with unresectable advanced or metastatic esophageal squamous cell carcinoma with tumor cell PD-L1 expression ≥1%, as well as in the all-randomized population. (link)
◦Six-and-a-half-year follow-up analysis from the Phase 3 CheckMate -067 study, which showed a continued, durable improvement in OS with Opdivo plus Yervoy therapy and
6

Opdivo monotherapy, versus Yervoy alone, in patients with previously untreated advanced melanoma. (link)
◦Two-year follow-up analysis from the Phase 3 CheckMate -9LA study, which demonstrated that Opdivo plus Yervoy with two cycles of chemotherapy showed a durable survival benefit compared to four cycles of chemotherapy alone after two years in patients with previously untreated, advanced non-small cell lung cancer (NSCLC). (link)
◦Four-year follow-up analysis from Part 1 of the Phase 3 CheckMate -227 study, which demonstrated a durable, long-term survival benefit of first-line treatment with Opdivo plus Yervoy compared to chemotherapy in patients with previously untreated, advanced NSCLC with a minimum follow-up of over four years (49.4 months). (link)

Hematology

Abecma

Regulatory
•In June, the company announced the CHMP of the EMA has recommended granting Conditional Marketing Authorization for Abecma® (idecabtagene vicleucel; ide-cel), the company’s B-cell maturation antigen (BCMA)-directed chimeric antigen receptor (CAR) T cell immunotherapy, for the treatment of adult patients with relapsed and refractory multiple myeloma who have received at least three prior therapies, including an immunomodulatory agent, a proteasome inhibitor and an anti-CD38 antibody and have demonstrated disease progression on the last therapy. The CHMP opinion was based on results from the pivotal Phase 2 KarMMa study. (link)

Breyanzi

Clinical
•In June, the company announced positive topline results from TRANSFORM, a global, randomized, multicenter Phase 3 study evaluating Breyanzi® (lisocabtagene maraleucel) as a second-line treatment in adults with relapsed or refractory large B-cell lymphoma (LBCL) compared to salvage therapy followed by high-dose chemotherapy and hematopoietic stem cell transplant, which is currently considered a gold standard treatment for these patients. (link)

7

Onureg

Regulatory
◦In June, the company announced that the EC has granted full Marketing Authorization for Onureg® (azacitidine tablets) as a maintenance therapy in adult patients with acute myeloid leukemia who achieved complete remission or complete remission with incomplete blood count recovery (CRi) following induction therapy with or without consolidation treatment and who are not candidates for, including those who choose not to proceed to, hematopoietic stem cell transplantation. The EC approval was based on results from the QUAZAR® AML-001 study. (link)

Medical Meetings
•In June, at the 26th European Hematology Association, the company announced new data and analyses from the:
◦Phase 2 BEYOND study with Acceleron Pharma Inc. (NASDAQ: XLRN), which showed treatment with Reblozyl® (luspatercept-aamt), a first-in-class erythroid maturation agent, plus best supportive care compared to placebo improved anemia in adult patients with non-transfusion dependent beta thalassemia. (link)

•In May, at the ASCO 2021 Annual Meeting, the company announced new data and analyses from the:
◦Pivotal Phase 2 KarMMa study with bluebird bio, Inc. (NASDAQ: BLUE), which showed patients treated with Abecma achieved an overall response rate that remained consistent or achieved a complete response or better after a median follow-up of 24.8 months. The data represent the longest follow-up to date from a global clinical trial of a CAR T cell therapy in multiple myeloma. (link)

Immunology

Zeposia

Regulatory
•In May, the company announced that the FDA approved Zeposia® (ozanimod) for the treatment of adults with moderately to severely active ulcerative colitis, a chronic
8

inflammatory bowel disease. The approval is based on data from the pivotal, Phase 3 True North study. (link)

Business Development
•In June, the company and Eisai Co., Ltd. announced that the companies have entered into an exclusive global strategic collaboration agreement for the co-development and co-commercialization of MORAb-202, an antibody drug conjugate. (link)
•In May, the company and Agenus Inc. (NASDAQ: AGEN) announced that they have entered into a definitive agreement under which Bristol Myers Squibb will be granted a global exclusive license to Agenus’ proprietary bispecific antibody program, AGEN1777, that blocks TIGIT and a second undisclosed target. (link)

Financial Guidance
Bristol Myers Squibb is updating its 2021 GAAP EPS guidance range of $3.18 - $3.38 to $2.77 - $2.97 and reaffirming its non-GAAP EPS guidance range of $7.35 - $7.55. Both GAAP and non-GAAP guidance assume current exchange rates. Key 2021 GAAP and non-GAAP line-item guidance assumptions are:

•Worldwide revenues increasing in the high-single digits.
•Gross margin as a percentage of revenue is expected to be approximately 79% for GAAP and approximately 80% for non-GAAP.
•Marketing, selling and administrative expenses to be in-line with 2020 levels for GAAP and increasing in the low-single digits for non-GAAP.
•Research and development expenses decreasing in the low-single digits for GAAP and increasing in the mid-single digits for non-GAAP.
•An effective tax rate of approximately 23% for GAAP and approximately 16% for non-GAAP.

The 2021 financial guidance excludes the impact of any potential future strategic acquisitions and divestitures, and any specified items that have not yet been identified and quantified. The 2021 non-GAAP EPS guidance is explained and further excludes other specified items as discussed under “Use of Non-GAAP Financial Information.” The financial guidance is subject to risks and uncertainties applicable to all forward-looking statements as described elsewhere in this press release.

9

Company and Conference Call Information
Bristol Myers Squibb is a global biopharmaceutical company whose mission is to discover, develop and deliver innovative medicines that help patients prevail over serious diseases. For more information about Bristol Myers Squibb, visit us at BMS.com or follow us on LinkedIn, Twitter, YouTube, Facebook, and Instagram.

There will be a conference call on July 28, 2021 at 8 a.m. ET during which company executives will review financial information and address inquiries from investors and analysts.
Investors and the general public are invited to listen to a live webcast of the call at
http://investor.bms.com or by using this link which becomes active 15 minutes prior to the scheduled start time and entering your information to be connected. Investors and the general public can also access the live webcast by dialing in the U.S. toll free 888-204-4368 or international +1 313-209-4906, confirmation code: 1720109. Materials related to the call will be available at the same website prior to the conference call.

A replay of the call will be available beginning at 11:30 a.m. ET on July 28 through 11:30 a.m. ET on August 11, 2021. The replay will also be available through http://investor.bms.com or by dialing in the U.S. toll free 888-203-1112 or international +1 719-457-0820, confirmation code: 1720109.

Use of Non-GAAP Financial Information
In discussing financial results and guidance, the company refers to financial measures that are not in accordance with U.S. Generally Accepted Accounting Principles (GAAP). The non-GAAP financial measures are provided as supplemental information to the financial measures presented in this press release that are calculated and presented in accordance with GAAP and are presented because management has evaluated the company’s financial results both including and excluding the adjusted items or the effects of foreign currency translation, as applicable, and believes that the non-GAAP financial measures presented portray the results of the company’s baseline performance, supplement or enhance management, analysts and investors overall understanding of the company’s underlying financial performance and trends and facilitate comparisons among current, past and future periods. For example, non-GAAP earnings and EPS information are indications of the company’s baseline performance before items that are considered by us to not be reflective of the company’s ongoing results. This information is among the primary indicators that we use as a basis for evaluating performance, allocating resources, setting incentive compensation targets and planning and forecasting for future periods. In addition, non-GAAP gross margin, which is gross profit excluding certain specified items as a percentage of revenues, non-GAAP marketing, selling and administrative expenses, which is marketing, selling and administrative expense excluding certain specified items, and non-GAAP research and development expenses, which is research and development expenses excluding certain specified items, are relevant and useful for investors because they allow investors to view performance in a manner similar to the method used by our management and make it easier for investors, analysts and peers
10

to compare our operating performance to other companies in our industry and to compare our year-over-year results.

This earnings release and the accompanying tables also provide certain revenues and expenses as well as non-GAAP measures excluding the impact of foreign exchange. We calculate foreign exchange impacts by converting our current-period local currency financial results using the prior period average currency rates and comparing these adjusted amounts to our current-period results.

Non-GAAP financial measures such as non-GAAP earnings and related EPS information are adjusted to exclude certain costs, expenses, gains and losses and other specified items that are evaluated on an individual basis after considering their quantitative and qualitative aspects and typically have one or more of the following characteristics, such as being highly variable, difficult to project, unusual in nature, significant to the results of a particular period or not indicative of past or future operating results. These items are excluded from non-GAAP earnings and related EPS information because the company believes they neither relate to the ordinary course of the company’s business nor reflect the company’s underlying business performance. Similar charges or gains were recognized in prior periods and will likely reoccur in future periods, including amortization of acquired intangible assets, including product rights that generate a significant portion of our ongoing revenue and will recur until the intangible assets are fully amortized, unwind of inventory fair value adjustments, acquisition and integration expenses, restructuring costs, accelerated depreciation and impairment of property, plant and equipment and intangible assets, R&D charges or other income resulting from upfront or contingent milestone payments in connection with the acquisition or licensing of third-party intellectual property rights, divestiture gains or losses, stock compensation resulting from accelerated vesting of Celgene awards, certain retention-related employee compensation charges related to the Celgene transaction, pension, legal and other contractual settlement charges, equity investment and contingent value rights fair value adjustments (including fair value adjustments attributed to limited partnership equity method investments beginning in 2021) and amortization of fair value adjustments of debt acquired from Celgene in our 2019 exchange offer, among other items. Certain other significant tax items are also excluded such as the impact resulting from internal transfer of intangible assets and the Otezla* divestiture in the second quarter 2020. Deferred and current income taxes attributed to these items are also adjusted for considering their individual impact to the overall tax expense, deductibility and jurisdictional tax rates.

Because the non-GAAP financial measures are not calculated in accordance with GAAP, they should not be considered superior to and are not intended to be considered in isolation or as a substitute for the related financial measures presented in the press release that are prepared in accordance with GAAP and may not be the same as or comparable to similarly titled measures presented by other companies due to possible differences in method and in the items being adjusted. We encourage investors to review our financial statements and publicly-filed reports in their entirety and not to rely on any single financial measure.

Reconciliations of the non-GAAP financial measures to the most comparable GAAP measures are provided in the accompanying financial tables and also available on the company’s website at www.bms.com. Within the attached financial tables presented, certain columns and rows may not add due to the use of rounded numbers. Percentages and earnings per share amounts presented are calculated from the underlying amounts.

11

Website Information
We routinely post important information for investors on our website, BMS.com, in the “Investors” section. We may use this website as a means of disclosing material, non-public information and for complying with our disclosure obligations under Regulation FD. Accordingly, investors should monitor the Investors section of our website, in addition to following our press releases, SEC filings, public conference calls, presentations and webcasts. We may also use social media channels to communicate with our investors and the public about our company, our products and other matters, and those communications could be deemed to be material information. The information contained on, or that may be accessed through, our website or social media channels are not incorporated by reference into, and are not a part of, this document.

Cautionary Statement Regarding Forward-Looking Statements
This earnings release and the related attachments (as well as the oral statements made with respect to information contained in this release and the attachments) contain certain “forward-looking” statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended, regarding, among other things, statements relating to goals, plans and projections regarding the company’s financial position, results of operations, market position, product development and business strategy. These statements may be identified by the fact they use words such as “should,” “could,” “expect,” “anticipate,” “estimate,” “target,” “may,” “project,” “guidance,” “intend,” “plan,” “believe,” “will” and other words and terms of similar meaning and expression in connection with any discussion of future operating or financial performance, although not all forward-looking statements contain such terms. One can also identify forward-looking statements by the fact that they do not relate strictly to historical or current facts. These statements are likely to relate to, among other things, the company’s ability to execute successfully its strategic plans, including its business development strategy generally and in relation to its ability to realize the projected benefits of the Celgene Acquisition and the MyoKardia Acquisition, the full extent of the impact of the COVID-19 pandemic on the company’s operations and the development and commercialization of its products, potential laws and regulations to lower drug costs, market actions taken by private and government payers to manage drug utilization and contain costs, the expiration of patents or data protection on certain products, including assumptions about the company’s ability to retain patent exclusivity of certain products, and the impact and the result of governmental investigations. No forward-looking statement can be guaranteed, including that the company’s future clinical studies will support the data described in this release, product candidates will receive necessary clinical and manufacturing regulatory approvals, pipeline products will prove to be commercially successful, clinical and manufacturing regulatory approvals will be sought or obtained within currently expected timeframes or contractual milestones will be achieved.

Such forward-looking statements are based on historical performance and current expectations and projections about the company’s future financial results, goals, plans and objectives and involve inherent risks, assumptions and uncertainties, including internal or external factors that could delay, divert or change any of them in the next several years, that are difficult to predict, may be beyond the company’s control and could cause the company’s future financial results, goals, plans and objectives to differ materially from those expressed in, or implied by, the statements. Such risks, uncertainties and other matters include, but are not limited to, risks relating to various risks related to public health outbreaks, epidemics and pandemics, including the impact of the COVID-19 pandemic on the company’s operations and that the company cannot reasonably assess or predict at this time the full extent of the adverse effect that the COVID-19 pandemic will have on its business, financial condition, results of operations and cash flows; increasing pricing pressures from market access, pharmaceutical pricing controls and discounting, changes to tax and importation laws and other restrictions in the United States, the European Union and other regions around the
12

world that result in lower prices, lower reimbursement rates and smaller populations for whom payers will reimburse; challenges inherent in new product development, including obtaining and maintaining regulatory approval; the company’s ability to obtain and protect market exclusivity rights and enforce patents and other intellectual property rights; the possibility of difficulties and delays in product introduction and commercialization; the risk of certain novel approaches to disease treatment (such as CAR T therapy); industry competition from other manufacturers; potential difficulties, delays and disruptions in manufacturing, distribution or sale of products, including without limitation, interruptions caused by damage to the company’s and the company’s suppliers’ manufacturing sites; the impact of integrating the company’s and Celgene’s business and operations, including with respect to human capital management, portfolio rationalization, finance and accounting systems, sales operations and product distribution, pricing systems and methodologies, data security systems, compliance programs and internal controls processes, on the company’s ability to realize the anticipated benefits from the Celgene Acquisition; the risk of an adverse patent litigation decision or settlement and exposure to other litigation and/or regulatory actions; the impact of any healthcare reform and legislation or regulatory action in the United States and international markets; changes in tax law and regulations; the failure of the company’s suppliers, vendors, outsourcing partners, alliance partners and other third parties to meet their contractual, regulatory and other obligations; regulatory decisions impacting labeling, manufacturing processes and/or other matters; the impact on the company’s competitive position from counterfeit or unregistered versions of its products or stolen products; the adverse impact of cyber-attacks on the company’s information systems or products, including unauthorized disclosure of trade secrets or other confidential data stored in the company’s information systems and networks; the company’s ability to execute its financial, strategic and operational plans; the company’s ability to identify potential strategic acquisitions, licensing opportunities or other beneficial transactions; the company’s dependency on several key products; any decline in the company’s future royalty streams; the company’s ability to effectively manage acquisitions, divestitures, alliances and other portfolio actions and to successfully realize the expected benefits of such actions; the company’s ability to attract and retain key personnel; the impact of the company’s significant additional indebtedness that it incurred in connection with the Celgene Acquisition and the MyoKardia Acquisition and its issuance of additional shares in connection with the Celgene Acquisition on its ability to operate the combined company; political and financial instability of international economies and sovereign risk; interest rate and currency exchange rate fluctuations, credit and foreign exchange risk management; the impact of our exclusive forum provision in our by-laws for certain lawsuits on our stockholders’ ability to obtain a judicial forum that it finds favorable for such lawsuits; and issuance of new or revised accounting standards. In addition, the financial guidance provided in this release relies on assumptions about the duration and severity of the COVID-19 pandemic, timing of the return to a more stable business environment, patient and physician behaviors, buying patterns and clinical trial activities (together, the “Recovery Process”), among other things. If the actual Recovery Process differs materially from our assumptions, the impact of COVID-19 on our business could be worse than expected and our results may be negatively impacted.

13

Forward-looking statements in this earnings release should be evaluated together with the many risks and uncertainties that affect the company’s business and market, particularly those identified in the cautionary statement and risk factors discussion in the company’s Annual Report on Form 10-K for the year ended December 31, 2020, as updated by the company’s subsequent Quarterly Reports on Form 10-Q, Current Reports on Form 8-K and other filings with the Securities and Exchange Commission. The forward-looking statements included in this document are made only as of the date of this document and except as otherwise required by applicable law, the company undertakes no obligation to publicly update or revise any forward-looking statement, whether as a result of new information, future events, changed circumstances or otherwise.
14

BRISTOL-MYERS SQUIBB COMPANY
PRODUCT REVENUES
FOR THE THREE MONTHS ENDED JUNE 30, 2021 AND 2020
(Unaudited, dollars in millions)
																																				
 	Worldwide Revenues		U.S. Revenues(b)	
 	2021		2020		% Change		2021		2020		% Change	
Prioritized Brands												
Revlimid	$	3,202 			$	2,884 			11 	%		$	2,164 			$	2,048 			6 	%	
Eliquis	2,792 			2,163 			29 	%		1,722 			1,363 			26 	%	
Opdivo	1,910 			1,653 			16 	%		1,076 			956 			13 	%	
Orencia	814 			750 			9 	%		593 			554 			7 	%	
Pomalyst/Imnovid	854 			745 			15 	%		567 			522 			9 	%	
Sprycel	541 			511 			6 	%		325 			308 			6 	%	
Yervoy	510 			369 			38 	%		328 			254 			29 	%	
Abraxane	296 			308 			(4)	%		234 			218 			7 	%	
Empliciti	86 			97 			(11)	%		51 			59 			(14)	%	
Reblozyl	128 			55 			**		110 			55 			100 	%	
Inrebic	16 			15 			7 	%		15 			15 			— 		
Onureg	12 			— 			N/A		12 			— 			N/A	
Zeposia	28 			1 			**		20 			1 			**	
Breyanzi	17 			— 			N/A		17 			— 			N/A	
Abecma	24 			— 			N/A		24 			— 			N/A	
												
Established Brands												
Vidaza	45 			126 			(64)	%		2 			— 			N/A	
Baraclude	109 			121 			(10)	%		2 			3 			(33)	%	
Other Brands(a)	319 			331 			(4)	%		126 			131 			(4)	%	

Total	$	11,703 			$	10,129 			16 	%		$	7,388 			$	6,487 			14 	%	
**    In excess of +/- 100%
(a)    Includes products that have lost exclusivity in major markets, over-the-counter (OTC) brands and royalty revenue.
(b)    Includes Puerto Rico.

15

BRISTOL-MYERS SQUIBB COMPANY
PRODUCT REVENUES
FOR THE SIX MONTHS ENDED JUNE 30, 2021 AND 2020
(Unaudited, dollars in millions)
																																				
 	Worldwide Revenues		U.S. Revenues(b)	
 	2021		2020		% Change		2021		2020		% Change	
Prioritized Brands												
Revlimid	$	6,146 			$	5,799 			6 	%		$	4,122 			$	4,014 			3 	%	
Eliquis	5,678 			4,804 			18 	%		3,645 			3,140 			16 	%	
Opdivo	3,630 			3,419 			6 	%		2,020 			1,964 			3 	%	
Orencia	1,572 			1,464 			7 	%		1,129 			1,054 			7 	%	
Pomalyst/Imnovid	1,627 			1,458 			12 	%		1,079 			1,011 			7 	%	
Sprycel	1,011 			1,032 			(2)	%		600 			608 			(1)	%	
Yervoy	966 			765 			26 	%		622 			511 			22 	%	
Abraxane	610 			608 			— 			459 			423 			9 	%	
Empliciti	171 			194 			(12)	%		102 			118 			(14)	%	
Reblozyl	240 			63 			**		208 			63 			**	
Inrebic	32 			27 			19 	%		30 			27 			11 	%	
Onureg	27 			— 			N/A		26 			— 			N/A	
Zeposia	46 			1 			**		33 			1 			**	
Breyanzi	17 			— 			N/A		17 			— 			N/A	
Abecma	24 			— 			N/A		24 			— 			N/A	
												
Established Brands												
Vidaza	99 			284 			(65)	%		7 			2 			**	
Baraclude	222 			243 			(9)	%		6 			6 			— 		
Other Brands(a)	658 			749 			(12)	%		269 			311 			(14)	%	

Total	$	22,776 			$	20,910 			9 	%		$	14,398 			$	13,253 			9 	%	
**    In excess of +/- 100%
(a)    Includes products that have lost exclusivity in major markets, over-the-counter (OTC) brands and royalty revenue.
(b)    Includes Puerto Rico.
16

BRISTOL-MYERS SQUIBB COMPANY
CONSOLIDATED STATEMENTS OF EARNINGS
FOR THE THREE AND SIX MONTHS ENDED JUNE 30, 2021 AND 2020
(Unaudited, dollars and shares in millions except per share data)
																								
 	Three Months Ended June 30,		Six Months Ended June 30,	
 	2021		2020		2021		2020	
Net product sales	$	11,405 			$	9,817 			$	22,203 			$	20,358 		
Alliance and other revenues	298 			312 			573 			552 		
Total Revenues	11,703 			10,129 			22,776 			20,910 		
								
Cost of products sold(a)	2,452 			2,699 			5,293 			6,361 		
Marketing, selling and administrative	1,882 			1,628 			3,548 			3,234 		
Research and development	3,271 			2,522 			5,496 			4,894 		
Amortization of acquired intangible assets	2,547 			2,389 			5,060 			4,671 		
Other (income)/expense, net	(2)			(736)			(704)			427 		
Total Expenses	10,150 			8,502 			18,693 			19,587 		
								
Earnings Before Income Taxes	1,553 			1,627 			4,083 			1,323 		
Provision for Income Taxes	492 			1,707 			993 			2,169 		
								
Net Earnings/(Loss)	1,061 			(80)			3,090 			(846)		
Noncontrolling Interest	6 			5 			14 			14 		
Net Earnings/(Loss) Attributable to BMS	$	1,055 			$	(85)			$	3,076 			$	(860)		
								
Weighted-Average Common Shares Outstanding:								
Basic	2,227 			2,263 			2,232 			2,261 		
Diluted	2,252 			2,263 			2,258 			2,261 		
								
Earnings/(Loss) per Common Share:								
Basic	$	0.47 			$	(0.04)			$	1.38 			$	(0.38)		
Diluted	0.47 			(0.04)			1.36 			(0.38)		
								
Other (income)/expense, net								
Interest expense(b)	$	330 			$	357 			$	683 			$	719 		
Contingent consideration	— 			(165)			(510)			391 		
Royalties and licensing income	(405)			(311)			(772)			(721)		
Equity investment gains	(148)			(818)			(749)			(480)		
Integration expenses	152 			166 			293 			340 		
Provision for restructuring	78 			115 			123 			275 		
Litigation and other settlements	44 			(1)			36 			31 		
Transition and other service fees	(22)			(50)			(37)			(111)		
Investment income	(12)			(25)			(21)			(86)		
Reversion excise tax	— 			— 			— 			76 		
Divestiture (gains)/losses	(11)			9 			(11)			(7)		
Intangible asset impairment	— 			21 			— 			21 		
	
Loss on debt redemption	— 			— 			281 			— 		

Other	(8)			(34)			(20)			(21)		
Other (income)/expense, net	$	(2)			$	(736)			$	(704)			$	427 		
(a)    Excludes amortization of acquired intangible assets.
(b)    Includes amortization of purchase price adjustments to Celgene debt.
17

BRISTOL-MYERS SQUIBB COMPANY
SPECIFIED ITEMS
FOR THE THREE AND SIX MONTHS ENDED JUNE 30, 2021 AND 2020
(Unaudited, dollars in millions)
																								
 	Three Months Ended June 30,		Six Months Ended June 30,	
 	2021		2020		2021		2020	
Inventory purchase price accounting adjustments	$	88 			$	714 			$	167 			$	2,134 		
Intangible asset impairment	— 			— 			315 			— 		
Employee compensation charges	— 			1 			— 			3 		
Site exit and other costs	1 			13 			24 			29 		
Cost of products sold	89 			728 			506 			2,166 		
								
Employee compensation charges	1 			12 			1 			27 		
Site exit and other costs	— 			(1)			(1)			5 		
Marketing, selling and administrative	1 			11 			— 			32 		
								
License and asset acquisition charges	780 			300 			780 			325 		
IPRD impairments	230 			— 			230 			— 		
Inventory purchase price accounting adjustments	— 			— 			— 			17 		
Employee compensation charges	— 			15 			1 			33 		
Site exit and other costs	— 			39 			— 			95 		
Research and development	1,010 			354 			1,011 			470 		
								
Amortization of acquired intangible assets	2,547 			2,389 			5,060 			4,671 		
								
Interest expense(a)	(28)			(41)			(62)			(82)		
Contingent consideration	— 			(165)			(510)			391 		
Royalties and licensing income	(15)			(18)			(29)			(101)		
Equity investment gains	(154)			(818)			(762)			(479)		
Integration expenses	152 			166 			293 			340 		
Provision for restructuring	78 			115 			123 			275 		

Reversion excise tax	— 			— 			— 			76 		
Divestiture (gains)/losses	(11)			9 			(11)			(7)		

	
Loss on debt redemption	— 			— 			281 			— 		
	
Other (income)/expense, net	22 			(752)			(677)			413 		
								
Increase to pretax income	3,669 			2,730 			5,900 			7,752 		
								
Income taxes on items above	(388)			(3)			(688)			(294)		
Income taxes attributed to Otezla® divestiture	— 			255 			— 			255 		
Income taxes attributed to internal transfer of intangible assets	— 			853 			— 			853 		
Income taxes	(388)			1,105 			(688)			814 		
								
Increase to net earnings	$	3,281 			$	3,835 			$	5,212 			$	8,566 		
(a) Includes amortization of purchase price adjustments to Celgene debt.
18

BRISTOL-MYERS SQUIBB COMPANY
RECONCILIATION OF CERTAIN GAAP LINE ITEMS TO CERTAIN NON-GAAP LINE ITEMS
FOR THE THREE AND SIX MONTHS ENDED JUNE 30, 2021 AND 2020
(Unaudited, dollars and shares in millions except per share data)
																																				
	Three Months Ended June 30, 2021		Six Months Ended June 30, 2021	
	GAAP		Specified Items(a)		Non-GAAP		GAAP		Specified Items(a)		Non-GAAP	
Gross Profit	$	9,251 			$	89 			$	9,340 			$	17,483 			$	506 			$	17,989 		
Marketing, selling and administrative	1,882 			(1)			1,881 			3,548 			— 			3,548 		
Research and development	3,271 			(1,010)			2,261 			5,496 			(1,011)			4,485 		
Amortization of acquired intangible assets	2,547 			(2,547)			— 			5,060 			(5,060)			— 		
Other (income)/expense, net	(2)			(22)			(24)			(704)			677 			(27)		
Earnings Before Income Taxes	1,553 			3,669 			5,222 			4,083 			5,900 			9,983 		
Provision for Income Taxes	492 			388 			880 			993 			688 			1,681 		
Noncontrolling interest	6 			— 			6 			14 			— 			14 		
												
Net Earnings Attributable to BMS used for Diluted EPS Calculation	$	1,055 			$	3,281 			$	4,336 			$	3,076 			$	5,212 			$	8,288 		
												
Weighted-Average Common Shares Outstanding - Diluted	2,252 			2,252 			2,252 			2,258 			2,258 			2,258 		
Diluted Earnings Per Share	$	0.47 			$	1.46 			$	1.93 			$	1.36 			$	2.31 			$	3.67 		
												
Effective Tax Rate	31.7 	%		(14.8)	%		16.9 	%		24.3 	%		(7.5)	%		16.8 	%	
												
	Three Months Ended June 30, 2020		Six Months Ended June 30, 2020	
	GAAP		Specified Items(a)		Non-GAAP		GAAP		Specified Items(a)		Non-GAAP	
Gross Profit	$	7,430 			$	728 			$	8,158 			$	14,549 			$	2,166 			$	16,715 		
Marketing, selling and administrative	1,628 			(11)			1,617 			3,234 			(32)			3,202 		
Research and development	2,522 			(354)			2,168 			4,894 			(470)			4,424 		
Amortization of acquired intangible assets	2,389 			(2,389)			— 			4,671 			(4,671)			— 		
Other (income)/expense, net	(736)			752 			16 			427 			(413)			14 		
Earnings Before Income Taxes	1,627 			2,730 			4,357 			1,323 			7,752 			9,075 		
Provision for Income Taxes	1,707 			(1,105)			602 			2,169 			(814)			1,355 		
Noncontrolling interest	5 			— 			5 			14 			— 			14 		
												
Net (Loss)/Earnings Attributable to BMS used for Diluted EPS Calculation	$	(85)			$	3,835 			$	3,750 			$	(860)			$	8,566 			$	7,706 		
												
Weighted-Average Common Shares Outstanding - Diluted	2,263 			2,297 			2,297 			2,261 			2,298 			2,298 		
Diluted (Loss)/Earnings Per Share	$	(0.04)			$	1.67 			$	1.63 			$	(0.38)			$	3.73 			$	3.35 		
												
Effective Tax Rate	104.9 	%		(91.1)	%		13.8 	%		163.9 	%		(149.0)	%		14.9 	%	
(a)    Refer to the Specified Items schedule for further details. Effective tax rate on the Specified Items represents the difference between the GAAP and Non-GAAP effective tax rate.

19

BRISTOL-MYERS SQUIBB COMPANY
NET DEBT CALCULATION
AS OF JUNE 30, 2021 AND DECEMBER 31, 2020
(Unaudited, dollars in millions)

												
	June 30,
2021		December 31,
2020	
Cash and cash equivalents	$	11,024 			$	14,546 		
Marketable debt securities - current	1,946 			1,285 		
Marketable debt securities - non-current	143 			433 		
Cash, cash equivalents and marketable debt securities	13,113 			16,264 		
	
Short-term debt obligations	(2,655)			(2,340)		
Long-term debt	(42,503)			(48,336)		
Net debt position	$	(32,045)			$	(34,412)		
20

Media:
media@bms.com

Investor Relations:
Tim Power, 609-252-7509, timothy.power@bms.com;
Nina Goworek, 908-673-9711, nina.goworek@bms.com.
21

Exhibit 99.2
BRISTOL-MYERS SQUIBB COMPANY
QUARTERLY TREND ANALYSIS OF REVENUES
(Unaudited, dollars in millions)

Revenues	2020		2021		% Change		FX Impact(b)	
 	1st Qtr		2nd Qtr		6 Months		3rd Qtr		9 Months		4th Qtr		Year		1st Qtr		2nd Qtr		6 Months		3rd Qtr		9 Months		4th Qtr		Year		Qtr vs. Qtr		YTD vs. YTD		Qtr vs. Qtr		YTD vs. YTD	
United States	$	6,766 			$	6,487 			$	13,253 			$	6,542 			$	19,795 			$	6,782 			$	26,577 			$	7,010 			$	7,388 			$	14,398 											14%		9%		—		—	
	
Europe	2,567 			2,136 			4,703 			2,453 			7,156 			2,697 			9,853 			2,553 			2,689 			5,242 											26%		11%		10%		9%	
	
Rest of the World	1,335 			1,334 			2,669 			1,361 			4,030 			1,427 			5,457 			1,346 			1,435 			2,781 											8%		4%		4%		3%	
	
Other(a)	113 			172 			285 			184 			469 			162 			631 			164 			191 			355 											11%		25%		—		—	
	
Total	$	10,781 			$	10,129 			$	20,910 			$	10,540 			$	31,450 			$	11,068 			$	42,518 			$	11,073 			$	11,703 			$	22,776 											16%		9%		3%		2%	
																																				
% of Revenues	2020		2021									
 	1st Qtr		2nd Qtr		6 Months		3rd Qtr		9 Months		4th Qtr		Year		1st Qtr		2nd Qtr		6 Months		3rd Qtr		9 Months		4th Qtr		Year									
United States	62.8 	%		64.0 	%		63.4 	%		62.1 	%		62.9 	%		61.3 	%		62.5 	%		63.3 	%		63.1 	%		63.2 	%																	
	
Europe	23.8 	%		21.1 	%		22.5 	%		23.3 	%		22.8 	%		24.4 	%		23.2 	%		23.1 	%		23.0 	%		23.0 	%																	
	
Rest of the World	12.4 	%		13.2 	%		12.8 	%		12.9 	%		12.8 	%		12.9 	%		12.8 	%		12.2 	%		12.3 	%		12.2 	%																	
	
Other	1.0 	%		1.7 	%		1.3 	%		1.7 	%		1.5 	%		1.4 	%		1.5 	%		1.4 	%		1.6 	%		1.6 	%																	
	
Total	100.0 	%		100.0 	%		100.0 	%		100.0 	%		100.0 	%		100.0 	%		100.0 	%		100.0 	%		100.0 	%		100.0 	%																	
(a)    Other revenues include royalties and alliance-related revenues for products not sold by our regional commercial organizations.
(b)    Foreign exchange impacts were derived by converting our current-period local currency financial results using the prior period average currency rates and comparing these adjusted amounts to our current-period results.
1

BRISTOL-MYERS SQUIBB COMPANY
EARNINGS FROM OPERATIONS
(Unaudited, dollars and shares in millions except per share data)

 	2020		2021		% Change	
 	1st Qtr		2nd Qtr		6 Months		3rd Qtr		9 Months		4th Qtr		Year		1st Qtr		2nd Qtr		6 Months		3rd Qtr		9 Months		4th Qtr		Year		Qtr vs. Qtr		YTD vs. YTD	
Net product sales	$	10,541 			$	9,817 			$	20,358 			$	10,197 			$	30,555 			$	10,766 			$	41,321 			$	10,798 			$	11,405 			$	22,203 											16%		9%	
Alliance and other revenues	240 			312 			552 			343 			895 			302 			1,197 			275 			298 			573 											(4)%		4%	
Total Revenues	10,781 			10,129 			20,910 			10,540 			31,450 			11,068 			42,518 			11,073 			11,703 			22,776 											16%		9%	
																																
Cost of products sold(a)	3,662 			2,699 			6,361 			2,502 			8,863 			2,910 			11,773 			2,841 			2,452 			5,293 											(9)%		(17)%	
Marketing, selling and administrative	1,606 			1,628 			3,234 			1,706 			4,940 			2,721 			7,661 			1,666 			1,882 			3,548 											16%		10%	
Research and development	2,372 			2,522 			4,894 			2,499 			7,393 			3,750 			11,143 			2,225 			3,271 			5,496 											30%		12%	
IPRD charge - MyoKardia acquisition	— 			— 			— 			— 			— 			11,438 			11,438 			— 			— 			— 											N/A		N/A	
Amortization of acquired intangible assets	2,282 			2,389 			4,671 			2,491 			7,162 			2,526 			9,688 			2,513 			2,547 			5,060 											7%		8%	
Other (income)/expense, net	1,163 			(736)			427 			(915)			(488)			(1,826)			(2,314)			(702)			(2)			(704)											(100)%		**	
Total Expenses	11,085 			8,502 			19,587 			8,283 			27,870 			21,519 			49,389 			8,543 			10,150 			18,693 											19%		(5)%	
																																
Earnings/(Loss) Before Income Taxes	(304)			1,627 			1,323 			2,257 			3,580 			(10,451)			(6,871)			2,530 			1,553 			4,083 											(5)%		**	
Provision/(Benefit) for Income Taxes	462 			1,707 			2,169 			379 			2,548 			(424)			2,124 			501 			492 			993 											(71)%		(54)%	
Net Earnings/(Loss)	(766)			(80)			(846)			1,878 			1,032 			(10,027)			(8,995)			2,029 			1,061 			3,090 											**		**	
Noncontrolling Interest	9 			5 			14 			6 			20 			— 			20 			8 			6 			14 											20%		—	
Net Earnings/(Loss) Attributable to BMS	$	(775)			$	(85)			$	(860)			$	1,872 			$	1,012 			$	(10,027)			$	(9,015)			$	2,021 			$	1,055 			$	3,076 											**		**	
																																
Diluted Earnings/(Loss) per Common Share*	$	(0.34)			$	(0.04)			$	(0.38)			$	0.82 			$	0.44 			$	(4.45)			$	(3.99)			$	0.89 			$	0.47 			$	1.36 											**		**	
Weighted-Average Common Shares Outstanding - Diluted	2,258 			2,263 			2,261 			2,290 			2,295 			2,252 			2,258 			2,265 			2,252 			2,258 											—		—	
Dividends declared per common share	$	0.45 			$	0.45 			$	0.90 			$	0.45 			$	1.35 			$	0.49 			$	1.84 			$	0.49 			$	0.49 			$	0.98 											9%		9%	
																																
	2020		2021					
% of Total Revenues	1st Qtr		2nd Qtr		6 Months		3rd Qtr		9 Months		4th Qtr		Year		1st Qtr		2nd Qtr		6 Months		3rd Qtr		9 Months		4th Qtr		Year					

	
Gross Margin	66.0 	%		73.4 	%		69.6 	%		76.3 	%		71.8 	%		73.7 	%		72.3 	%		74.3 	%		79.0 	%		76.8 	%													
																																
Other Ratios																																
Effective tax rate	(152.0)	%		104.9 	%		163.9 	%		16.8 	%		71.2 	%		4.1 	%		(30.9)	%		19.8 	%		31.7 	%		24.3 	%													
																																
Other (income)/expense, net	2020		2021		% Change	
	1st Qtr		2nd Qtr		6 Months		3rd Qtr		9 Months		4th Qtr		Year		1st Qtr		2nd Qtr		6 Months		3rd Qtr		9 Months		4th Qtr		Year		Qtr vs. Qtr		YTD vs. YTD	
Interest expense(b)	$	362 			$	357 			$	719 			$	346 			$	1,065 			$	355 			$	1,420 			$	353 			$	330 			$	683 											(8)%		(5)%	
Contingent consideration	556 			(165)			391 			(988)			(597)			(1,160)			(1,757)			(510)			— 			(510)											(100)%		**	
Royalties and licensing income	(410)			(311)			(721)			(403)			(1,124)			(403)			(1,527)			(367)			(405)			(772)											30%		7%	
Equity investment (gains)/losses	338 			(818)			(480)			(244)			(724)			(504)			(1,228)			(601)			(148)			(749)											(82)%		56%	
Integration expenses	174 			166 			340 			195 			535 			182 			717 			141 			152 			293 											(8)%		(14)%	
Provision for restructuring	160 			115 			275 			176 			451 			79 			530 			45 			78 			123 											(32)%		(55)%	
Litigation and other settlements	32 			(1)			31 			10 			41 			(235)			(194)			(8)			44 			36 											**		16%	
Transition and other service fees	(61)			(50)			(111)			(18)			(129)			(20)			(149)			(15)			(22)			(37)											(56)%		(67)%	
Investment income	(61)			(25)			(86)			(13)			(99)			(22)			(121)			(9)			(12)			(21)											(52)%		(76)%	
Reversion excise tax	76 			— 			76 			— 			76 			— 			76 			— 			— 			— 											N/A		(100)%	
Divestiture (gains)/losses	(16)			9 			(7)			1 			(6)			(49)			(55)			— 			(11)			(11)											**		57%	
Intangible asset impairment	— 			21 			21 			— 			21 			— 			21 			— 			— 			— 											(100)%		(100)%	
	
Loss on debt redemption	— 			— 			— 			— 			— 			— 			— 			281 			— 			281 											N/A		N/A	

Other	13 			(34)			(21)			23 			2 			(49)			(47)			(12)			(8)			(20)											(76)%		(5)%	
Other (income)/expense, net	$	1,163 			$	(736)			$	427 			$	(915)			$	(488)			$	(1,826)			$	(2,314)			$	(702)			$	(2)			$	(704)											(100)%		**	
*    Quarterly amounts may not add to the year-to-date amounts, as each period is computed on a discrete basis.
**    In excess of +/- 100%.
(a)    Excludes amortization of acquired intangible assets.
(b)    Includes amortization of purchase price adjustments to Celgene debt.
2

BRISTOL-MYERS SQUIBB COMPANY
RECONCILIATION OF GAAP AND NON-GAAP GROWTH DOLLARS AND PERCENTAGES EXCLUDING FOREIGN EXCHANGE IMPACT
FOR THE PERIOD ENDED JUNE 30, 2021
(Unaudited, dollars in millions)

QUARTER-TO-DATE	2021		2020		$ Change		% Change		Favorable / (Unfavorable) FX Impact $*		2021 Excluding FX		Favorable / (Unfavorable) FX Impact %*		% Change Excluding FX	
Revenues	$	11,703 			$	10,129 			$	1,574 			16 	%		$	276 			$	11,427 			3 	%		13 	%	
Gross profit	9,251 			7,430 			1,821 			25 	%		N/A		 N/A		N/A		N/A	
Gross profit excluding specified items(a)	9,340 			8,158 			1,182 			14 	%		N/A		 N/A		N/A		N/A	
																
Gross profit excluding specified items as a % of revenues	79.8 	%		80.5 	%													
																
Marketing, selling and administrative	1,882 			1,628 			254 			16 	%		(38)			1,844 			(3)	%		13 	%	
Marketing, selling and administrative excluding specified items(a)	1,881 			1,617 			264 			16 	%		(38)			1,843 			(2)	%		14 	%	
																
Marketing, selling and administrative excluding specified items as a % of revenues	16.1 	%		16.0 	%													
																
Research and development	3,271 			2,522 			749 			30 	%		(16)			3,255 			(1)	%		29 	%	
Research and development excluding specified items(a)	2,261 			2,168 			93 			4 	%		(16)			2,245 			— 			4 	%	
																
Research and development excluding specified items as a % of revenues	19.3 	%		21.4 	%													
																
YEAR-TO-DATE	2021		2020		$ Change		% Change		Favorable / (Unfavorable) FX Impact $*		2021 Excluding FX		Favorable / (Unfavorable) FX Impact %*		% Change Excluding FX	
Revenues	$	22,776 			$	20,910 			$	1,866 			9 	%		$	499 			$	22,277 			2 	%		7 	%	
Gross profit	17,483 			14,549 			2,934 			20 	%		N/A		N/A		N/A		N/A	
Gross profit excluding specified items(a)	17,989 			16,715 			1,274 			8 	%		N/A		N/A		N/A		N/A	
																
Gross profit excluding specified items as a % of revenues	79.0 	%		79.9 	%													
																
Marketing, selling and administrative	3,548 			3,234 			314 			10 	%		(66)			3,482 			(2)	%		8 	%	
Marketing, selling and administrative excluding specified items(a)	3,548 			3,202 			346 			11 	%		(66)			3,482 			(2)	%		9 	%	
																
Marketing, selling and administrative excluding specified items as a % of revenues	15.6 	%		15.3 	%													
																
Research and development	5,496 			4,894 			602 			12 	%		(28)			5,468 			— 			12 	%	
Research and development excluding specified items(a)	4,485 			4,424 			61 			1 	%		(28)			4,457 			— 			1 	%	
																
Research and development excluding specified items as a % of revenues	19.7 	%		21.2 	%													
*    Foreign exchange impacts were derived by converting our current-period local currency financial results using the prior period average currency rates and comparing these adjusted amounts to our current-period results.
(a)    Refer to the Specified Items schedule for further details.
3

BRISTOL-MYERS SQUIBB COMPANY
WORLDWIDE REVENUES
QUARTERLY REVENUES TREND ANALYSIS
(Unaudited, dollars in millions)

 	2020		2021		$ Change		% Change	
 	1st Qtr		2nd Qtr		6 Months		3rd Qtr		9 Months		4th Qtr		Year		1st Qtr		2nd Qtr		6 Months		3rd Qtr		9 Months		4th Qtr		Year		Qtr vs. Qtr		YTD vs. YTD		Qtr vs. Qtr		YTD vs. YTD	
Prioritized Brands																																			
Revlimid	$	2,915 			$	2,884 			$	5,799 			$	3,027 			$	8,826 			$	3,280 			$	12,106 			$	2,944 			$	3,202 			$	6,146 											$	318 			$	347 			11%		6%	
Eliquis	2,641 			2,163 			4,804 			2,095 			6,899 			2,269 			9,168 			2,886 			2,792 			5,678 											629 			874 			29%		18%	
Opdivo	1,766 			1,653 			3,419 			1,780 			5,199 			1,793 			6,992 			1,720 			1,910 			3,630 											257 			211 			16%		6%	
Orencia	714 			750 			1,464 			826 			2,290 			867 			3,157 			758 			814 			1,572 											64 			108 			9%		7%	
Pomalyst/Imnovid	713 			745 			1,458 			777 			2,235 			835 			3,070 			773 			854 			1,627 											109 			169 			15%		12%	
Sprycel	521 			511 			1,032 			544 			1,576 			564 			2,140 			470 			541 			1,011 											30 			(21)			6%		(2)%	
Yervoy	396 			369 			765 			446 			1,211 			471 			1,682 			456 			510 			966 											141 			201 			38%		26%	
Abraxane	300 			308 			608 			342 			950 			297 			1,247 			314 			296 			610 											(12)			2 			(4)%		—	
Empliciti	97 			97 			194 			96 			290 			91 			381 			85 			86 			171 											(11)			(23)			(11)%		(12)%	
Reblozyl	8 			55 			63 			96 			159 			115 			274 			112 			128 			240 											73 			177 			**		**	
Inrebic	12 			15 			27 			13 			40 			15 			55 			16 			16 			32 											1 			5 			7%		19%	
Onureg	— 			— 			— 			3 			3 			14 			17 			15 			12 			27 											12 			27 			N/A		N/A	
Zeposia	— 			1 			1 			2 			3 			9 			12 			18 			28 			46 											27 			45 			**		**	
Breyanzi	— 			— 			— 			— 			— 			— 			— 			— 			17 			17 											17 			17 			N/A		N/A	
Abecma	— 			— 			— 			— 			— 			— 			— 			— 			24 			24 											24 			24 			N/A		N/A	
																																				
Established Brands																																			
Vidaza	158 			126 			284 			106 			390 			65 			455 			54 			45 			99 											(81)			(185)			(64)%		(65)%	
Baraclude	122 			121 			243 			100 			343 			104 			447 			113 			109 			222 											(12)			(21)			(10)%		(9)%	
Other Brands(a)	418 			331 			749 			287 			1,036 			279 			1,315 			339 			319 			658 											(12)			(91)			(4)%		(12)%	
																																				
Total	$	10,781 			$	10,129 			$	20,910 			$	10,540 			$	31,450 			$	11,068 			$	42,518 			$	11,073 			$	11,703 			$	22,776 											$	1,574 			$	1,866 			16%		9%	
**    In excess of +/- 100%.
(a)    Includes products that have lost exclusivity in major markets, over-the-counter (OTC) brands and royalty revenue.

4

BRISTOL-MYERS SQUIBB COMPANY
U.S. REVENUES
QUARTERLY REVENUES TREND ANALYSIS
(Unaudited, dollars in millions)

 	2020		2021		% Change	
 	1st Qtr		2nd Qtr		6 Months		3rd Qtr		9 Months		4th Qtr		Year		1st Qtr		2nd Qtr		6 Months		3rd Qtr		9 Months		4th Qtr		Year		Qtr vs. Qtr		YTD vs. YTD	
Prioritized Brands																																
Revlimid	$	1,966 			$	2,048 			$	4,014 			$	2,080 			$	6,094 			$	2,197 			$	8,291 			$	1,958 			$	2,164 			$	4,122 											6%		3%	
Eliquis	1,777 			1,363 			3,140 			1,118 			4,258 			1,227 			5,485 			1,923 			1,722 			3,645 											26%		16%	
Opdivo	1,008 			956 			1,964 			1,018 			2,982 			963 			3,945 			944 			1,076 			2,020 											13%		3%	
Orencia	500 			554 			1,054 			588 			1,642 			626 			2,268 			536 			593 			1,129 											7%		7%	
Pomalyst/Imnovid	489 			522 			1,011 			548 			1,559 			577 			2,136 			512 			567 			1,079 											9%		7%	
Sprycel	300 			308 			608 			336 			944 			351 			1,295 			275 			325 			600 											6%		(1)%	
Yervoy	257 			254 			511 			309 			820 			304 			1,124 			294 			328 			622 											29%		22%	
Abraxane	205 			218 			423 			236 			659 			214 			873 			225 			234 			459 											7%		9%	
Empliciti	59 			59 			118 			59 			177 			53 			230 			51 			51 			102 											(14)%		(14)%	
Reblozyl	8 			55 			63 			92 			155 			104 			259 			98 			110 			208 											100%		**	
Inrebic	12 			15 			27 			13 			40 			15 			55 			15 			15 			30 											—		11%	
Onureg	— 			— 			— 			3 			3 			14 			17 			14 			12 			26 											N/A		N/A	
Zeposia	— 			1 			1 			2 			3 			7 			10 			13 			20 			33 											**		**	
Breyanzi	— 			— 			— 			— 			— 			— 			— 			— 			17 			17 											N/A		N/A	
Abecma	— 			— 			— 			— 			— 			— 			— 			— 			24 			24 											N/A		N/A	
																																
Established Brands																																
Vidaza	2 			— 			2 			— 			2 			— 			2 			5 			2 			7 											N/A		**	
Baraclude	3 			3 			6 			3 			9 			3 			12 			4 			2 			6 											(33)%		—	
Other Brands(a)	180 			131 			311 			137 			448 			127 			575 			143 			126 			269 											(4)%		(14)%	
																																
Total(b)	$	6,766 			$	6,487 			$	13,253 			$	6,542 			$	19,795 			$	6,782 			$	26,577 			$	7,010 			$	7,388 			$	14,398 											14%		9%	
**    In excess of +/- 100%.
(a)    Includes products that have lost exclusivity in major markets, OTC brands and royalty revenue.
(b)    Includes Puerto Rico.

5

BRISTOL-MYERS SQUIBB COMPANY
INTERNATIONAL REVENUES
QUARTERLY REVENUES TREND ANALYSIS
(Unaudited, dollars in millions)

 	2020		2021		% Change(b)	
 	1st Qtr		2nd Qtr		6 Months		3rd Qtr		9 Months		4th Qtr		Year		1st Qtr		2nd Qtr		6 Months		3rd Qtr		9 Months		4th Qtr		Year		Qtr vs. Qtr		YTD vs. YTD	
Prioritized Brands																																
Revlimid	$	949 			$	836 			$	1,785 			$	947 			$	2,732 			$	1,083 			$	3,815 			$	986 			$	1,038 			$	2,024 											24%		13%	
Eliquis	864 			800 			1,664 			977 			2,641 			1,042 			3,683 			963 			1,070 			2,033 											34%		22%	
Opdivo	758 			697 			1,455 			762 			2,217 			830 			3,047 			776 			834 			1,610 											20%		11%	
Orencia	214 			196 			410 			238 			648 			241 			889 			222 			221 			443 											13%		8%	
Pomalyst/Imnovid	224 			223 			447 			229 			676 			258 			934 			261 			287 			548 											29%		23%	
Sprycel	221 			203 			424 			208 			632 			213 			845 			195 			216 			411 											6%		(3)%	
Yervoy	139 			115 			254 			137 			391 			167 			558 			162 			182 			344 											58%		35%	
Abraxane	95 			90 			185 			106 			291 			83 			374 			89 			62 			151 											(31)%		(18)%	
Empliciti	38 			38 			76 			37 			113 			38 			151 			34 			35 			69 											(8)%		(9)%	
Reblozyl	— 			— 			— 			4 			4 			11 			15 			14 			18 			32 											N/A		N/A	
Inrebic	— 			— 			— 			— 			— 			— 			— 			1 			1 			2 											N/A		N/A	
Onureg	— 			— 			— 			— 			— 			— 			— 			1 			— 			1 											N/A		N/A	
Zeposia	— 			— 			— 			— 			— 			2 			2 			5 			8 			13 											N/A		N/A	
																																
Established Brands																																
Vidaza	156 			126 			282 			106 			388 			65 			453 			49 			43 			92 											(66)%		(67)%	
Baraclude	119 			118 			237 			97 			334 			101 			435 			109 			107 			216 											(9)%		(9)%	
Other Brands(a)	238 			200 			438 			150 			588 			152 			740 			196 			193 			389 											(4)%		(11)%	
																																
Total	$	4,015 			$	3,642 			$	7,657 			$	3,998 			$	11,655 			$	4,286 			$	15,941 			$	4,063 			$	4,315 			$	8,378 											18%		9%	
(a)    Includes products that have lost exclusivity in major markets, OTC brands and royalty revenue.
(b)    The foreign exchange impact on international revenues was favorable 8% for the second quarter and 7% year-to-date. The foreign exchange impact on Prioritized Brands is included below.

	Quarter-to-Date	Year-to-Date	
	Revenue Change %	Favorable/ (Unfavorable) FX Impact %	Revenue Change % Excluding FX	Revenue Change %	Favorable/ (Unfavorable) FX Impact %	Revenue Change % Excluding FX	
Revlimid	24%	8%	16%	13%	7%	6%	
Eliquis	34%	10%	24%	22%	9%	13%	
Opdivo	20%	7%	13%	11%	5%	6%	
Orencia	13%	6%	7%	8%	5%	3%	
Pomalyst/Imnovid	29%	6%	23%	23%	6%	17%	
Sprycel	6%	4%	2%	(3)%	4%	(7)%	
Yervoy	58%	10%	48%	35%	7%	28%	
Abraxane	(31)%	5%	(36)%	(18)%	4%	(22)%	
Empliciti	(8)%	3%	(11)%	(9)%	4%	(13)%	
6

BRISTOL-MYERS SQUIBB COMPANY
SPECIFIED ITEMS
(Unaudited, dollars in millions)

 	2020		2021	
	1st Qtr		2nd Qtr		6 Months		3rd Qtr		9 Months		4th Qtr		Year		1st Qtr		2nd Qtr		6 Months		3rd Qtr		9 Months		4th Qtr		Year	
	
Inventory purchase price accounting adjustments	$	1,420 			$	714 			$	2,134 			$	456 			$	2,590 			$	98 			$	2,688 			$	79 			$	88 			$	167 										
Intangible asset impairment	— 			— 			— 			— 			— 			575 			575 			315 			— 			315 										
Employee compensation charges	2 			1 			3 			— 			3 			1 			4 			— 			— 			— 										
Site exit and other costs	16 			13 			29 			3 			32 			1 			33 			23 			1 			24 										
Cost of products sold	1,438 			728 			2,166 			459 			2,625 			675 			3,300 			417 			89 			506 										
																												
Employee compensation charges	15 			12 			27 			7 			34 			241 			275 			— 			1 			1 										
Site exit and other costs	6 			(1)			5 			(1)			4 			— 			4 			(1)			— 			(1)										
Marketing, selling and administrative	21 			11 			32 			6 			38 			241 			279 			(1)			1 			— 										
																												
License and asset acquisition charges	25 			300 			325 			203 			528 			475 			1,003 			— 			780 			780 										
IPRD impairments	— 			— 			— 			— 			— 			470 			470 			— 			230 			230 										
Inventory purchase price accounting adjustments	17 			— 			17 			8 			25 			11 			36 			— 			— 			— 										
Employee compensation charges	18 			15 			33 			8 			41 			241 			282 			1 			— 			1 										
Site exit and other costs	56 			39 			95 			4 			99 			16 			115 			— 			— 			— 										
Research and development	116 			354 			470 			223 			693 			1,213 			1,906 			1 			1,010 			1,011 										
																												
IPRD charge - MyoKardia acquisition	— 			— 			— 			— 			— 			11,438 			11,438 			— 			— 			— 										
																												
Amortization of acquired intangible assets	2,282 			2,389 			4,671 			2,491 			7,162 			2,526 			9,688 			2,513 			2,547 			5,060 										
																												
Interest expense(a)	(41)			(41)			(82)			(40)			(122)			(37)			(159)			(34)			(28)			(62)										
Contingent consideration	556 			(165)			391 			(988)			(597)			(1,160)			(1,757)			(510)			— 			(510)										
Royalties and licensing income	(83)			(18)			(101)			(53)			(154)			(14)			(168)			(14)			(15)			(29)										
Equity investment (gains)/losses	339 			(818)			(479)			(214)			(693)			(463)			(1,156)			(608)			(154)			(762)										
Integration expenses	174 			166 			340 			195 			535 			182 			717 			141 			152 			293 										
Provision for restructuring	160 			115 			275 			176 			451 			79 			530 			45 			78 			123 										
Litigation and other settlements	— 			— 			— 			— 			— 			(239)			(239)			— 			— 			— 										
	
Reversion excise tax	76 			— 			76 			— 			76 			— 			76 			— 			— 			— 										
Divestiture (gains)/losses	(16)			9 			(7)			1 			(6)			(49)			(55)			— 			(11)			(11)										
	
Loss on debt redemption	— 			— 			— 			— 			— 			— 			— 			281 			— 			281 										

	
Other (income)/expense, net	1,165 			(752)			413 			(923)			(510)			(1,701)			(2,211)			(699)			22 			(677)										
																												
Increase to pretax income	5,022 			2,730 			7,752 			2,256 			10,008 			14,392 			24,400 			2,231 			3,669 			5,900 										
																												
Income taxes on items above	(291)			(3)			(294)			(405)			(699)			(1,034)			(1,733)			(300)			(388)			(688)										
Income taxes attributed to Otezla® divestiture	— 			255 			255 			11 			266 			— 			266 			— 			— 			— 										
Income taxes attributed to internal transfer of intangible assets	— 			853 			853 			— 			853 			— 			853 			— 			— 			— 										
Income taxes	(291)			1,105 			814 			(394)			420 			(1,034)			(614)			(300)			(388)			(688)										
																												
Increase to net earnings	$	4,731 			$	3,835 			$	8,566 			$	1,862 			$	10,428 			$	13,358 			$	23,786 			$	1,931 			$	3,281 			$	5,212 										

	
	
(a)    Includes amortization of purchase price adjustments to Celgene debt.
7

BRISTOL-MYERS SQUIBB COMPANY
RECONCILIATION OF CERTAIN GAAP LINE ITEMS TO CERTAIN NON-GAAP LINE ITEMS
(Unaudited, dollars in millions)

 	2020		2021	
 	1st Qtr		2nd Qtr		6 Months		3rd Qtr		9 Months		4th Qtr		Year		1st Qtr		2nd Qtr		6 Months		3rd Qtr		9 Months		4th Qtr		Year	
Gross Profit	$	7,119 			$	7,430 			$	14,549 			$	8,038 			$	22,587 			$	8,158 			$	30,745 			$	8,232 			$	9,251 			$	17,483 										
Specified items(a)	1,438 			728 			2,166 			459 			2,625 			675 			3,300 			417 			89 			506 										
Gross profit excluding specified items	8,557 			8,158 			16,715 			8,497 			25,212 			8,833 			34,045 			8,649 			9,340 			17,989 										
																												
Marketing, selling and administrative	1,606 			1,628 			3,234 			1,706 			4,940 			2,721 			7,661 			1,666 			1,882 			3,548 										
Specified items(a)	(21)			(11)			(32)			(6)			(38)			(241)			(279)			1 			(1)			— 										
Marketing, selling and administrative excluding specified items	1,585 			1,617 			3,202 			1,700 			4,902 			2,480 			7,382 			1,667 			1,881 			3,548 										
																												
Research and development	2,372 			2,522 			4,894 			2,499 			7,393 			3,750 			11,143 			2,225 			3,271 			5,496 										
Specified items(a)	(116)			(354)			(470)			(223)			(693)			(1,213)			(1,906)			(1)			(1,010)			(1,011)										
Research and development excluding specified items	2,256 			2,168 			4,424 			2,276 			6,700 			2,537 			9,237 			2,224 			2,261 			4,485 										
																												
IPRD charge –MyoKardia acquisition	— 			— 			— 			— 			— 			11,438 			11,438 			— 			— 			— 										
Specified items(a)	— 			— 			— 			— 			— 			(11,438)			(11,438)			— 			— 			— 										
IPRD charge –MyoKardia acquisition excluding specified items	— 			— 			— 			— 			— 			— 			— 			— 			— 			— 										
																												
Amortization of acquired intangible assets	2,282 			2,389 			4,671 			2,491 			7,162 			2,526 			9,688 			2,513 			2,547 			5,060 										
Specified items(a)	(2,282)			(2,389)			(4,671)			(2,491)			(7,162)			(2,526)			(9,688)			(2,513)			(2,547)			(5,060)										
Amortization of acquired intangible assets excluding specified items	— 			— 			— 			— 			— 			— 			— 			— 			— 			— 										
																												
Other (income)/expense, net	1,163 			(736)			427 			(915)			(488)			(1,826)			(2,314)			(702)			(2)			(704)										
Specified items(a)	(1,165)			752 			(413)			923 			510 			1,701 			2,211 			699 			(22)			677 										
Other (income)/expense, net excluding specified items	(2)			16 			14 			8 			22 			(125)			(103)			(3)			(24)			(27)										
(a)    Refer to the Specified Items schedule for further details.

8

BRISTOL-MYERS SQUIBB COMPANY
RECONCILIATION OF GAAP TO NON-GAAP EPS
(Unaudited, dollars and shares in millions except per share data)

 	2020		2021	
 	1st Qtr		2nd Qtr		6 Months		3rd Qtr		9 Months		4th Qtr		Year		1st Qtr		2nd Qtr		6 Months		3rd Qtr		9 Months		4th Qtr		Year	
Earnings/(Loss) before income taxes	$	(304)			$	1,627 			$	1,323 			$	2,257 			$	3,580 			$	(10,451)			$	(6,871)			$	2,530 			$	1,553 			$	4,083 										
Specified items(a)	5,022 			2,730 			7,752 			2,256 			10,008 			14,392 			24,400 			2,231 			3,669 			5,900 										
Earnings before income taxes excluding specified items	4,718 			4,357 			9,075 			4,513 			13,588 			3,941 			17,529 			4,761 			5,222 			9,983 										
																												
Provision/(Benefit) for income taxes	462 			1,707 			2,169 			379 			2,548 			(424)			2,124 			501 			492 			993 										
Income taxes on specified items(a)	291 			3 			294 			405 			699 			1,034 			1,733 			300 			388 			688 										
Income taxes attributed to Otezla® divestiture(a)	— 			(255)			(255)			(11)			(266)			— 			(266)			— 			— 			— 										
Income taxes attributed to internal transfer of intangible assets(a)	— 			(853)			(853)			— 			(853)			— 			(853)			— 			— 			— 										
Provision for income taxes excluding tax on specified items and income taxes attributed to Otezla® divestiture and internal transfer of intangible assets	753 			602 			1,355 			773 			2,128 			610 			2,738 			801 			880 			1,681 										
																												
Noncontrolling Interest	9 			5 			14 			6 			20 			— 			20 			8 			6 			14 										
Specified items(a)	— 			— 			— 			— 			— 			— 			— 			— 			— 			— 										
Noncontrolling Interest excluding specified items	9 			5 			14 			6 			20 			— 			20 			8 			6 			14 										
																												
Net Earnings/(Loss) attributable to BMS used for Diluted EPS Calculation - GAAP	(775)			(85)			(860)			1,872 			1,012 			(10,027)			(9,015)			2,021 			1,055 			3,076 										
Specified items(a)	4,731 			3,835 			8,566 			1,862 			10,428 			13,358 			23,786 			1,931 			3,281 			5,212 										
Net Earnings attributable to BMS used for Diluted EPS Calculation excluding specified items - Non-GAAP	3,956 			3,750 			7,706 			3,734 			11,440 			3,331 			14,771 			3,952 			4,336 			8,288 										
																												
Weighted-average Common Shares Outstanding - Diluted-GAAP	2,258 			2,263 			2,261 			2,290 			2,295 			2,252 			2,258 			2,265 			2,252 			2,258 										
Weighted-average Common Shares Outstanding - Diluted-Non-GAAP	2,298 			2,297 			2,298 			2,290 			2,295 			2,286 			2,293 			2,265 			2,252 			2,258 										
																												
Diluted Earnings/(Loss) Per Share - GAAP*	$	(0.34)			$	(0.04)			$	(0.38)			$	0.82 			$	0.44 			$	(4.45)			$	(3.99)			$	0.89 			$	0.47 			$	1.36 										
Diluted Earnings Per Share attributable to specified items(a)	2.06 			1.67 			3.73 			0.81 			4.54 			5.91 			10.43 			0.85 			1.46 			2.31 										
Diluted Earnings Per Share - Non-GAAP*	$	1.72 			$	1.63 			$	3.35 			$	1.63 			$	4.98 			$	1.46 			$	6.44 			$	1.74 			$	1.93 			$	3.67 										
																												
Effective Tax Rate	(152.0)	%		104.9 	%		163.9 	%		16.8 	%		71.2 	%		4.1 	%		(30.9)	%		19.8 	%		31.7 	%		24.3 	%									
Specified items(a)	168.0 	%		(91.1)	%		(149.0)	%		0.3 	%		(55.5)	%		11.4 	%		46.5 	%		(3.0)	%		(14.8)	%		(7.5)	%									
Effective Tax Rate excluding specified items	16.0 	%		13.8 	%		14.9 	%		17.1 	%		15.7 	%		15.5 	%		15.6 	%		16.8 	%		16.9 	%		16.8 	%									
*    Quarterly amounts may not add to the year-to-date amounts, as each period is computed on a discrete basis.
(a)    Refer to the Specified Items schedule for further details. Effective tax rate on the Specified Items represents the difference between the GAAP and Non-GAAP effective tax rate.

9

BRISTOL-MYERS SQUIBB COMPANY
SELECTED BALANCE SHEET INFORMATION
(Unaudited, dollars in millions)

	March 31,
2020		June 30,
2020		September 30,
2020		December 31,
2020		March 31,
2021		June 30,
2021		September 30,
2021		December 31,
2021	
Cash and cash equivalents	$	15,817 			$	19,934 			$	19,435 			$	14,546 			$	10,982 			$	11,024 						
Marketable debt securities - current	2,505 			1,724 			1,720 			1,285 			1,948 			1,946 						
Marketable debt securities - non-current	651 			523 			495 			433 			288 			143 						
Cash, cash equivalents and marketable debt securities	18,973 			22,181 			21,650 			16,264 			13,218 			13,113 						
																
Short-term debt obligations	(3,862)			(4,819)			(3,585)			(2,340)			(1,777)			(2,655)						
Long-term debt	(42,844)			(41,853)			(41,364)			(48,336)			(44,505)			(42,503)						
Net debt position	$	(27,733)			$	(24,491)			$	(23,299)			$	(34,412)			$	(33,064)			$	(32,045)						
10

BRISTOL-MYERS SQUIBB COMPANY
2021 FULL YEAR PROJECTED DILUTED EPS FROM OPERATIONS
EXCLUDING PROJECTED SPECIFIED ITEMS

	Full Year 2021	
	Pre-tax		Tax		After-tax	
Projected Diluted Earnings Attributable to Shareholders per Common Share - GAAP					$2.77 to $2.97	
						
Projected Specified Items:						
Purchase price accounting adjustments(a)	4.57 			0.41 			4.16 		
Acquisition, restructuring and integration expenses(b)	0.36 			0.08 			0.28 		
Equity investment gains and contingent consideration	(0.57)			(0.07)			(0.50)		
Research and development license and asset acquisition charges	0.44 			0.06 			0.38 		
Intangible asset impairment	0.24 			0.05 			0.19 		
Loss on debt redemption	0.13 			0.03 			0.10 		
Other	(0.03)			— 			(0.03)		
Total	5.14 			0.56 			4.58 		
						
Projected Diluted Earnings Attributable to Shareholders per Common Share - Non-GAAP					$7.35 to $7.55	
(a)    Includes amortization of acquired intangible assets, unwind of inventory fair value adjustments and amortization of fair value adjustments of debt assumed from Celgene.
(b)    Includes acquisition-related restructuring and integration expenses recognized primarily in Other (income)/expense, net.
															
The following table summarizes the company's 2021 financial guidance:	
	
Line item		GAAP		Non-GAAP	
	
Revenues		Increasing high-single digits		Increasing high-single digits	
					
Gross margin as a percent of revenue		Approximately 79%		Approximately 80%	
					
Marketing, selling and administrative expense		In line with 2020		Increasing low-single digits	
					
Research and development expense		Decreasing low-single digits		Increasing mid-single digits	
					
Effective tax rate		Approximately 23%		Approximately 16%	

			
The GAAP financial results for the full year of 2021 will include specified items, including purchase price accounting adjustments, acquisition and integration expenses, charges associated with restructuring, downsizing and streamlining worldwide operations, research and development license and asset acquisition charges, impairment of intangible assets, divestiture gains or losses, stock compensation resulting from accelerated vesting of Celgene awards, certain retention-related employee compensation charges related to the Celgene transaction and equity investment and contingent value rights fair value adjustments (including fair value adjustments attributed to limited partnership equity method investments), among other items. The 2021 financial guidance excludes the impact of any potential future strategic acquisitions and divestitures and any specified items that have not yet been identified and quantified. For a fuller discussion of items that could impact full year GAAP results, as well as the use of non-GAAP financial information, see Bristol Myers Squibb Reports Second Quarter Financial Results for 2021 on July 28, 2021, including “2021 Financial Guidance” and “Use of non-GAAP Financial Information” therein.	
11

Q2 2021 Results July 28, 2021

 

Q2 2021 Results Not for Product Promotional Use Forward Looking Statement and Non-GAAP Financial Information 2 This presentation contains statements about the Company’s future plans and prospects that constitute forward-looking statements for purposes of the safe harbor provisions under the Private Securities Litigation Reform Act of 1995. Actual results may differ materially from those indicated as a result of various important factors, including those discussed in the Company’s most recent annual report on Form 10-K and reports on Form 10-Q and Form 8-K. These documents are available on the SEC’s website, on the Bristol-Myers Squibb website or from Bristol-Myers Squibb Investor Relations. In addition, any forward-looking statements represent our estimates only as of the date hereof and should not be relied upon as representing our estimates as of any subsequent date. While we may elect to update forward-looking statements at some point in the future, we specifically disclaim any obligation to do so, even if our estimates change. This presentation includes certain non-generally accepted accounting principles (GAAP) financial measures that we use to describe our company’s performance. The non-GAAP information presented provides investors with additional useful information but should not be considered in isolation or as substitutes for the related GAAP measures. Moreover, other companies may define non-GAAP measures differently, which limits the usefulness of these measures for comparisons with such other companies. We encourage investors to review our financial statements and publicly-filed reports in their entirety and not to rely on any single financial measure. An explanation of these non-GAAP financial measures and a reconciliation to the most directly comparable GAAP financial measure are available on our website at bms.com/investors. Also note that a reconciliation of certain forward-looking statements, however, is not provided due to no reasonably accessible or reliable comparable GAAP measures for such statements and the inherent difficulty in forecasting and quantifying such statements that are necessary for such reconciliation.

 

Not for Product Promotional Use Q2 2021 Results Giovanni Caforio Board Chair and Chief Executive Officer 3

 

Q2 2021 Results Not for Product Promotional Use Operational Performance Strong commercial execution • Sales of $11.7B in Q2; +16% YoY, +13% ex-FX • Strong momentum with launches for I-O and new product portfolio Pipeline Execution Significant milestones • Solid Tumors: Opdivo U.S. approval in adj. EC/GEJ & positive CHMP opinion; Opdivo in adj. MIBC - PDUFA Sep 3, 2021 • Hematology: Positive data for Breyanzi in 2L TE LBCL; Abecma positive CHMP opinion in 4L+ MM; iberdomide + dex in 4L+ MM data in-house • Immunology: Zeposia U.S. approval in moderate-to-severe UC • CV: Milvexian (FXIa inhibitor) Ph 2 TKR data in-house • ] Financial Strength Strong financial results and outlook • Continued revenue and EPS growth • Reaffirm 2021 Revenue and Non-GAAP EPS guidance • Balance sheet strength and strong cash flow generation; debt repayments of ~$5.7B & executed share repurchases of ~$3B YTD Business Development • Licensed anti-TIGIT bispecific antibody program w/ Agenus & FRα ADC collab w/ Eisai Q2 2021 Performance 4

 

Q2 2021 Results Not for Product Promotional Use Opdivo (+/- Yervoy) U.S./EU expected approvals: 1L RCC (9ER) , 1L GC (649, O+Chemo), adj Eso (577) adj MIBC (274) 1L Esophageal (CM-648) Opdivo return to annual growth Relatlimab 1L Melanoma w/ Opdivo Ph3 Breyanzi 3L+ DLBCL U.S. / EU approval 2L TE and TNE DLBCL 3L+ CLL Abecma 4L+ MM U.S.1 / EU approval Iberdomide + dex 4L+ MM Ph 1b/2a Deucravacitinib PsO (2nd study) Ph3 & U.S. filing UC Ph2 (POC) Zeposia UC U.S. / EU approval Cendakimab Initiation of Ph3 Factor XIa inh. Total Knee Replacement VTEp Ph2 (POC) Mavacamten oHCM U.S. filing & approval2 Opdivo (+/- Yervoy) Metastatic 1L HCC (CM-9DW) Adjuvant Neo-adj Lung EFS (CM-816) Peri-adj Lung (CM-77T) Bempeg 1L melanoma3 & 1L renal Breyanzi 3L+ Follicular lymphoma Abecma 3L+ MM (KarMMa-3) Ph3 2L+ MM (KarMMa-2) POC CC-92480 4L+ MM Ph1/2 CC-93269 (TCE) Initiation of pivotal trial Deucravacitinib PsO U.S./EU approval CD & Lupus Ph2 (POC) Zeposia CD Ph3 Factor XIa inh. Secondary Stroke Prevention Ph2 (POC) Reblozyl 1L MDS (ESA naïve) COMMANDS Ph3 Ph 1/2 Pipeline >20 POC decisions 5 2021 Key Milestones Execution Scorecard • 2020-2025:  Low to mid-single digit revenue CAGR*  Low double-digit revenue CAGR for Continuing business* • Operating margins low to mid 40%s** • ~$3B of synergies by end of 2022 • $45B - $50B of free- cash flow 2021-2023** Financial Expectations 2022/2023 Key Milestones To be expanded to include regulatory milestones pending future registrational successes On track based on 2021 guidance 1Approved after 4 prior lines of therapy 2 PDUFA January 28, 2022 3 Expected in 2022 *At constant exchange rates – Non-GAAP: there is no reliable or reasonable estimable comparable GAAP metric for this Non-GAAP forward-looking information; **Non-GAAP: there is no reliable or reasonable estimable comparable GAAP metric for this forward-looking information

 

Q2 2021 Results Not for Product Promotional Use Continued portfolio renewal into 2H of decade 6 *Non-risk adjusted revenue potential is subject to positive registrational trials & health authority approval for Reblozyl, Zeposia, Onureg, Inrebic, Breyanzi, Abecma, Deucravacitinib, and Mavacamten Anticipated Launches deucravacitinib mavacamten Launch Portfolio Best / first-in-class assets $20B-$25B NRA revenue potential in 2029* relatlimab Future growth opportunities • Additional mid-to late-stage pipeline, including: • Diverse early-stage pipeline • Balance Sheet strength for additional BD opportunities iberdomide milvexian + relatlimab

 

Not for Product Promotional Use David Elkins Chief Financial Officer 7 Q2 2021 Results

 

Q2 2021 Results Not for Product Promotional Use Net Sales $ in Billions Vs. Prior Year $3.2 11% $2.8 29% $1.9 16% $0.9 15% $0.8 9% $0.5 6% $0.5 38% $0.3 4% Strong performance in key franchises 8 Net Sales $ in Billions Vs. Prior Year $6.1 6% $5.7 18% $3.6 6% $1.6 12% $1.6 7% $1.0 2% $1.0 26% $0.6 0% YTD SalesQ2 Sales ▲ ▲ ▲ ▲ ▲ ▲ ▲ ▲ ▲ ▲ - Q2 2021 Total Sales: $11.7B, up 16% & 13% ex-FX ▲ ▲ ▲ ▲ ▲ YTD 2021 Total Sales: $22.8B, up 9% & 7% ex-FX

 

Q2 2021 Results Not for Product Promotional Use US: Continued significant demand growth • Q2 sales up 26% vs PY; 16% YTD • Continued strong underlying demand • ~14% TRx growth Q2 2021 Eliquis performance 9Rx Source: Symphony Health Significant future growth opportunity • Expect to continue to grow share within an expanding class International: Strong demand growth • Continues to be #1 OAC in key markets with future growth Global net sales up 29% in Q2; 18% YTD 49% 55% 24% 20% 27% 25% Q2 2020 Q2 2021 TRx Share - US Other NOACs Warfarin Eliquis 59% 63% 15% 12% 26% 25% Q2 2020 Q2 2021 NBRx Share – US

 

Q2 2021 Results Not for Product Promotional Use Global net sales up 16% in Q2 U.S. • Return to growth (+13% vs. PY) • 1L lung* shares in low double-digits • Leadership position in 1L renal enabled by O+Cabo • Strong early launches in Upper GI International • Momentum from new launches, FX, improved COVID dynamics vs. PY Q2 2021 Opdivo performance 10 24% 24%29% 23% Approx. U.S. Sales Mix Note: percentages approximate based on tumor ranges 33% 20% 25% 22% Approx. Ex-U.S. Sales Mix NSCLC RCC Melanoma All others Near term growth drivers • Momentum from recent launches • Potential next launches: adjuvant bladder (CM-274), 1L esophageal (CM-648) *excluding EGFR/ALK patients

 

Q2 2021 Results Not for Product Promotional Use Q2 2021 Multiple Myeloma performance 11 $522 $567 $223 $287 Q2 2020 Q2 2021 Global sales growth of 11% • US sales growth of 6% • Increased use of triplet regimens & longer treatment duration • Recovery to pre-COVID levels in NRx • International sales growth of 24% • Demand from triplets & maintenance use • Improved COVID dynamics & FX Global sales growth of 15% • Demand growth from new triplet regimens and use in earlier lines Global Net Sales $2,048 $2,164 $836 $1,038 Q2 2020 Q2 2021 US Ex-US

 

Q2 2021 Results Not for Product Promotional Use • Continued transition from initial bolus to underlying incidence demand • Remain focused on new patients earlier in their treatment journey & dose optimization • Expansion in global markets Advancing new product launches 12 • #1 S1P modulator in written Rx in MS • Acceleration of Rx to commercial demand • UC approved in the U.S. - positive physician receptivity • MAA under review • Strong demand growth sequentially • Establishing profile in 1L response maintenance setting in AML • Approved by EC June 2021 $96 $115 $112 $128 $2 $9 $18 $28 $3 $14 $15 $12 Q3 2020 Q4 2020 Q1 2021 Q2 2021 Q2 2021 Global Net Sales Reblozyl Zeposia Onureg

 

Q2 2021 Results Not for Product Promotional Use Cell Therapy Performance 13 • Rapid site activation (>65 sites) • Strong demand and physician awareness Best-in-class CD19 CAR T Global net sales: $17M First-in-class BCMA CAR T Global net sales: $24M Two differentiated CAR T products, now in the marketplace

 

Q2 2021 Results Not for Product Promotional Use New Launch Sales Performance • Contributed $225M in Q2’21 • Approaching ~$1B annual run rate • Strong outlook for future growth 14 $71 $153 $225 Q2 2020 Q4 2020 Q2 2021 US International New Launches are comprised of Reblozyl, Zeposia, Onureg, Breyanzi, Abecma, and Inrebic

 

Q2 2021 Results Not for Product Promotional Use US GAAP Non-GAAP $ in billions, except EPS Q2 2021 Q2 2020 Q2 2021 Q2 2020 Total Revenues, net 11.7 10.1 11.7 10.1 Gross Margin % 79.0% 73.4% 79.8% 80.5% MS&A 1.9 1.6 1.9 1.6 R&D 3.3 2.5 2.3 2.2 Effective Tax Rate 31.7% 104.9% 16.9% 13.8% Diluted EPS 0.47 (0.04) 1.93 1.63 Diluted Shares Outstanding (# in millions) 2,252 2,263 2,252 2,297 Q2 2021 Financial Performance 15

 

Q2 2021 Results Not for Product Promotional Use Significant financial flexibility to support a balanced approach to capital allocation 16 $B Q2 2021 Total Cash** $13.1B Total Debt $45.2B Net Debt Position $32.0B *Subject to Board approval **Cash includes cash, cash equivalents and marketable debt securities Committed to reducing debt • ~$5.7B in debt reduction YTD • Maintain strong investment-grade credit ratings Returning capital to shareholders • Continued dividend growth* • $3B - $4B total share repurchase planned; executed ~$3B YTD & remain opportunistic in 2H Future innovation through business development • Strategically Aligned • Scientifically Sound • Financially Attractive

 

Q2 2021 Results Not for Product Promotional Use 2021 Guidance Details 17 GAAP Non-GAAP Net Sales High single-digit increase High single-digit increase Gross Margin % ~79% ~80% MS&A Expense In line with 2020 Low single-digit increase R&D Expense Low single-digit decrease Mid single-digit increase Tax Rate ~23% ~16% Diluted EPS $2.77-$2.97 $7.35 - $7.55 Refer to separate reconciliation of GAAP to these non-GAAP measures on company’s website Non-GAAP EPS reaffirmed

 

Q2 2021 Results Not for Product Promotional Use Q&A Giovanni Caforio, M.D. Board Chair, Chief Executive Officer David Elkins Executive VP, Chief Financial Officer 18 Chris Boerner, Ph.D. Executive VP, Chief Commercialization Officer Samit Hirawat, M.D. Executive VP, Chief Medical Officer, Global Drug Development

 

Q2 2021 Results Not for Product Promotional Use 2021 News Flow 19 Asset Timing Opdivo Approval in 1L renal (CM-9ER) Approved in U.S. & EU Opdivo Approval in 1L gastric (CM-649) Approved in U.S. Opdivo Approval in adjuvant esophageal (CM-577) Approved MAA under review Opdivo Approval in adjuvant MIBC (CM-274) PDUFA date September 3, 2021 Opdivo CM-648 in 1L esophageal Positive topline April 2021 Relatlimab + Opdivo vs Opdivo mono 1L Melanoma CA224-047 Positive topline March 2021 Breyanzi Approval in 3L+ LBCL Approved in U.S. MAA under review Breyanzi 2L DLBCL 3L+ CLL Positive topline June 2021 2H 2021 Asset Timing Abecma Approval in 4L+ MM Approved in U.S. 1 MAA under review Zeposia Approval in UC Approved in U.S MAA under review iberdomide + dex Data in-house 2 deucravacitinib Psoriasis Ph3 POETYK PSO-2 (IM011-047) Positive topline Feb 2021 deucravacitinib Ph2 POC in UC 2H 2021 milvexian (FXIa inhib) POC in VTEp for total knee replacement Data in-house 2 mavacamten Obstructive HCM PDUFA date January 28, 2022 1 Approved after 4 prior lines of therapy 2 Expect to present data in 2H 2021

 

Not for product promotional use Hematology Fibrosis pegbelfermin HSP47 LPA1 Antagonist JNK Inhibitor Immunology Oncology Data as of July 21, 2021 Anti-Fucosyl GM1 Anti-OX40 STING Agonist Anti-NKG2A Anti-SIRPα* Anti-TIM3 Anti-CTLA-4 NF Anti-CCR8 Anti-CTLA-4 Probody BCMA TCE AR LDD CD3xPSCA (GEMoaB)** Anti-IL8 Anti-TIGIT relatlimab* bempegal- desleukin linrodostat BET Inhibitor (BMS-986158) CD19 NEX T BCMA ADC BCMA CAR T (bb21217) TGFβ Inhibitor LSD1 Inhibitor* iberdomide *In development for solid tumors and hematology **BMS has an exclusive option to license and/or option to acquire iberdomide MK2 InhibitorAnti-CD40 IL2-CD25 Imm. Tolerance (Anokion)** IL2 Mutein cendakimab branebrutinib deucravacitinib Cardiovascular FA-Relaxin FXIa Inhibitor 20 Phase 1 Phase 2 Phase 3 A/I CELMoD (CC-92480) A/I CELMoD (CC-99282) GSPT1 CELMoD (CC-90009) BET Inhibitor* (CC-90010) CD33 NKE CD47xCD20 Neuroscience Anti-Tau (Prothena)** AHR Antagonist (Ikena)** S1PR1 Modulator TLR 7/8 Inhibitor CD22 ADC (TriPhase)** BET Inhibitor* (CC-95775) NME 1 FPR-2 Agonist Active Clinical Development Portfolio motolimod NLRP3 Agonist danicamtiv BCMA NEX T IL-12 Fc Cardiac Myosin Inhibitor milvexian (FXIa Inhibitor) mavacamten CD3xCD33 (GEMoaB)** TYK2 Inhibitor TYK2 Inhibitor (Nimbus)** GPRC5D CAR T COVID-19 SARS-CoV-2 mAb Duo Anti-CTLA-4 NF-Probody CK1α CELMoD ROMK Inhibitor BTK Inhibitor * BCMA NKE ROR1 CAR T TIGIT Bispecific (Agenus)** FRα ADC FAAH/MGLL Dual Inhibitor subcutaneous nivolumab Marketed