{\rtf1\ansi\ansicpg1252\uc1\deff0\deflang1033 {\colortbl\red0\green0\blue0;\red222\green26\blue30;\red204\green238\blue255;\red128\green128\blue128;}{\fonttbl{\f2\fswiss Arial;}{\f1\fmodern Courier New;}{\f3\fdecor Symbol;}{\f0\froman Times New Roman;}{\f4\fnil Wingdings;}} {\info{\subject EDGAR Online Pro}{\version3}{\*\company EDGAR Online, Inc.}{\author EDGAR Online HTML to RTF Converter. Version 3.0}{\*\category \0001193125-19-164070.html.ecq}{\doccomm Source: EDGAR Online, Inc. \'a9 Copyright 2019. All rights reserved.}{\title Sientra, Inc. (Form: 424B5, Received: 06/03/2019 16:02:57)}} \paperh15840\paperw12240\margl360\margr360\margt360\margb360\headery0\footery360\sprstsp\sprsbsp\sprsspbf\sprslnsp\widowctrl\viewscale100 {\*\bkmkstart eolPage1}{\*\bkmkend eolPage1}{\*\bkmkstart FIS_TOP_OF_DOCUMENT}{\*\bkmkend FIS_TOP_OF_DOCUMENT}{\*\bkmkstart D754322D424B5_HTM}{\*\bkmkend D754322D424B5_HTM}{\*\bkmkstart FIS_FORM}{\*\bkmkend FIS_FORM}\pard {\fs16\b {\field\fldedit{\*\fldinst { HYPERLINK "" \\l "D754322D424B5_HTM_TOC"}}{\fldrslt\ul {Table of Contents}}}}\par \pard \qr \sb240 {\fs20 {\b Filed Pursuant to Rule 424(b)(5)\line Registration No. 333-231288}}{\*\bkmkstart FIS_SUBJECT_STOCK_INFO}{\*\bkmkend FIS_SUBJECT_STOCK_INFO}\par \pard \qc {\fs20 {\cf1 {\b \line SUBJECT TO COMPLETION, DATED JUNE 3, 2019}}}\par \pard {\fs16 \u160?}\par \pard {\fs19 {\cf1 The information in this preliminary prospectus supplement is not complete and may be changed. Neither this preliminary prospectus supplement nor the accompanying prospectus is an offer to sell these securities, and we are not soliciting an offer to buy these securities, in any jurisdiction where the offer or sale is not permitted.}}\par \pard {\fs16 \u160?}\par \pard {\fs22 {\b PRELIMINARY PROSPECTUS SUPPLEMENT}}\par \pard {\fs22 {\b (To prospectus dated May 22, 2019)}}\par \pard {\fs8 \u160?}\par \pard \brdrb\brdrs\brdrw20\brdrcf0 {\fs20 \u160?}\par \pard \sb60 {\fs20 \u160?}\par \pard \qc {\fs20 {\pict\jpegblip\pichgoal465\picwgoal1995\bin3930 JFIF C C 8 !1"Qa#q%&')23ABc 0 !1AQaq2"R ? Ǣ)7gb{f`좒jș\x3&F 9$oaՋRuiw/O ,R(tGL:Q7^ilhPËK;LMHntt73J!˷x#'ʵjzLSB,vNȘ1"D|(FaZ{1mv@Q˫Su%XgW+@L?; r>AyS+;sy^q_5Pi:-"bz5NbISԦ.&*dE6Nt:qGWjjV^J 6NP@K;7f2R Ah"^R)z"l݀Sk}XZqLb1в8?#8_q#gG`Dݕ cn % DT]_XŶpVyP {##LFbE[ODSE=ODHOWPyCniؚܹ,yMw?&elR7HES8`M6S$g6J|k$Т29VwƜ3nt#u4Vt g1\( ax(yq19:òl!{witjt; iU9#Q[# EE ZL'aZ/cą&NKma gDw$ҕČ5hacJ1ICepb5XƌVm%$a͝E[۰hCSX;Q,lʦ̃8T`BXL6ijah鞽htgݗƻJкeM4|w!ᠢ'M m)j uy`ٝ zuDԻyZnP@5{']ې0YDsA"aM:0"d'?[KocDxO|y%fkEӅl7U[5tR6dO==DPʫ,M79bevlv;p>LMuVԜ巧%ɮ*E~!q3Aʎ]w`ig+JHs)uorHuH (q[ׯg </gg!Ͳ>irIܱb|[쯎%Xdfn0d lVf+I dؒҔ:upy"p_3trڷfE_+w}h@2P]dN}Ύd6%BW*=aԾbssfQ+"n>gmS5gNjхM[!aRV($#II YN~\ESwf~B{2mʩEهR͉n]rjRXd Lf|!&҇p}ű8ka%kNkz5`uWH:9iႺHHIR5