FORM 4
[ ] Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).         	UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES
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                      	Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940	                      	

1. Name and Address of Reporting Person *

Hu George	2. Issuer Name and Ticker or Trading Symbol

TWILIO INC [ TWLO ]	5. Relationship of Reporting Person(s) to Issuer (Check all applicable)

_____ Director                      _____ 10% Owner
__ X __ Officer (give title below)      _____ Other (specify below)
Chief Operating Officer	
(Last)          (First)          (Middle)

C/O TWILIO INC., 375 BEALE STREET, SUITE 300	3. Date of Earliest Transaction (MM/DD/YYYY)

11/13/2018		
(Street)

SAN FRANCISCO, CA 94105
(City)        (State)        (Zip)	4. If Amendment, Date Original Filed (MM/DD/YYYY)

 	6. Individual or Joint/Group Filing (Check Applicable Line)

_ X _ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person	

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned	
1.Title of Security
(Instr. 3)	2. Trans. Date	2A. Deemed Execution Date, if any	3. Trans. Code
(Instr. 8)	4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)	5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)	
			Code	V	Amount	(A) or (D)	Price				
Class A Common Stock  	11/13/2018  	 	M	  	5000  	A	$31.72  	200150   (1)	D  	 	
Class A Common Stock  	11/13/2018  	 	S (2)	  	2497  	D	$84.4465   (3)	197653   (1)	D  	 	
Class A Common Stock  	11/13/2018  	 	S (2)	  	1903  	D	$85.4723   (4)	195750   (1)	D  	 	
Class A Common Stock  	11/13/2018  	 	S (2)	  	400  	D	$86.7275   (5)	195350   (1)	D  	 	
Class A Common Stock  	11/13/2018  	 	S (2)	  	200  	D	$87.395   (6)	195150   (1)	D  	 	
Class A Common Stock  	11/14/2018  	 	M	  	5000  	A	$31.72  	200150   (1)	D  	 	
Class A Common Stock  	11/14/2018  	 	S (2)	  	700  	D	$83.4929   (7)	199450   (1)	D  	 	
Class A Common Stock  	11/14/2018  	 	S (2)	  	2100  	D	$84.5819   (8)	197350   (1)	D  	 	
Class A Common Stock  	11/14/2018  	 	S (2)	  	1700  	D	$85.4124   (9)	195650   (1)	D  	 	
Class A Common Stock  	11/14/2018  	 	S (2)	  	400  	D	$86.4013   (10)	195250   (1)	D  	 	
Class A Common Stock  	11/14/2018  	 	S (2)	  	100  	D	$87.27  	195150   (1)	D  	 	

Table II - Derivative Securities Beneficially Owned ( e.g. , puts, calls, warrants, options, convertible securities)	
1. Title of Derivate Security
(Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Trans. Date	3A. Deemed Execution Date, if any	4. Trans. Code
(Instr. 8)	5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)	6. Date Exercisable and Expiration Date	7. Title and Amount of Securities Underlying Derivative Security
(Instr. 3 and 4)	8. Price of Derivative Security
(Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)	
				Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares					
Employee Stock Option (right to buy)  	$31.72  	11/13/2018  	 	M  	  	  	5000   	  (11)	2/27/2024  	Class A Common Stock  	5000  	$0  	752600  	D  	 	
Employee Stock Option (right to buy)  	$31.72  	11/14/2018  	 	M  	  	  	5000   	  (11)	2/27/2024  	Class A Common Stock  	5000  	$0  	747600  	D  	 	
Employee Stock Option (right to buy)  	$31.72  	 	 	   	  	  	  	  (12)	2/27/2024  	Class A Common Stock  	185000  	 	185000  	D  	 	
Employee Stock Option (right to buy)  	$33.01  	 	 	   	  	  	  	  (13)	2/19/2028  	Class A Common Stock  	96214  	 	96214  	D  	 	

Explanation of Responses:	
(1) 	A portion of these shares represent Restricted Stock Units ("RSUs"). Each RSU represents the contingent right to receive one share of the Issuer's Class A common stock.	
(2) 	The sales reported were effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person.	
(3) 	The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $83.94 to $84.92 per share, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or to the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.	
(4) 	The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $85.16 to $85.96 per share, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or to the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.	
(5) 	The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $86.19 to $87.18 per share, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or to the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.	
(6) 	The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $87.33 to $87.46 per share, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or to the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.	
(7) 	The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $82.97 to $83.89 per share, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or to the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.	
(8) 	The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $84.00 to $84.97 per share, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or to the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.	
(9) 	The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $85.01 to $85.99 per share, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or to the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.	
(10) 	The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $86.05 to $86.875 per share, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or to the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.	
(11) 	The shares subject to the stock option vest as follows: 25% of the stock option vested on February 28, 2018 and the remaining shares subject to the stock option shall vest in equal monthly installments over the following three years, subject to the Reporting Person's continued service to the Issuer through each vesting date.	
(12) 	The shares subject to the stock option vest as follows: 50% of the stock option vested on March 31, 2018 and the remaining shares subject to the stock option shall vest in 24 equal monthly installments thereafter, subject to the Reporting Person's continued service to the Issuer through each vesting date.	
(13) 	The shares subject to the stock option vest as follows: 1/48th of the shares vested on March 15, 2018 and the remaining shares subject to the stock option shall vest in equal monthly installments over the following four years, subject to the Reporting Person's continued service to the Issuer through each vesting date.	

Reporting Owners	
Reporting Owner Name / Address	Relationships	
	Director	10% Owner	Officer	Other	
Hu George
C/O TWILIO INC.
375 BEALE STREET, SUITE 300
SAN FRANCISCO, CA 94105			Chief Operating Officer		

Signatures		
/s/ Alexis Rhorer as attorney in fact for Reporting Person		11/15/2018	
** Signature of Reporting Person		Date

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.	
*	If the form is filed by more than one reporting person, see Instruction 4(b)(v).	
**	Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).	
Note:	File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.	
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB control number.