PHASERX, INC., 10-Q filed on 11/9/2017
Quarterly Report
Document And Entity Information
9 Months Ended
Sep. 30, 2017
Nov. 3, 2017
Document Information [Line Items]
 
 
Document Type
10-Q 
 
Amendment Flag
false 
 
Document Period End Date
Sep. 30, 2017 
 
Document Fiscal Year Focus
2017 
 
Document Fiscal Period Focus
Q3 
 
Entity Registrant Name
PHASERX, INC. 
 
Entity Central Index Key
0001429386 
 
Current Fiscal Year End Date
--12-31 
 
Entity Filer Category
Smaller Reporting Company 
 
Trading Symbol
PZRX 
 
Entity Common Stock, Shares Outstanding
 
11,690,329 
Consolidated Balance Sheets (USD $)
In Thousands, unless otherwise specified
Sep. 30, 2017
Dec. 31, 2016
Current assets
 
 
Cash and cash equivalents
$ 5,257 
$ 9,983 
Marketable securities
5,496 
Prepaids and other current assets
572 
698 
Total current assets
5,829 
16,177 
Property and equipment, net
209 
271 
Total assets
6,038 
16,448 
Current liabilities
 
 
Accounts payable
556 
515 
Accrued liabilities
296 
884 
Accrued interest
46 
49 
Current portion of term loan payable
1,830 
576 
Total current liabilities
2,728 
2,024 
Term loan payable, net of debt discount and current portion
3,611 
5,127 
Total liabilities
6,339 
7,151 
Stockholders’ equity (deficit)
 
 
Preferred stock, $0.0001 par value, 5,000,000 shares authorized at September 30, 2017 and December 31, 2016; no shares issued and outstanding at September 30, 2017 and December 31, 2016
Common stock; $0.0001 par value; 50,000,000 shares authorized at September 30, 2017 and December 31, 2016; 11,690,329 shares issued and outstanding at September 30, 2017 and December 31, 2016
Additional paid-in capital
79,695 
78,773 
Accumulated other comprehensive income
Accumulated deficit
(79,997)
(69,480)
Total stockholders' equity (deficit)
(301)
9,297 
Total liabilities and stockholders' equity (deficit)
$ 6,038 
$ 16,448 
Consolidated Balance Sheets (Parenthetical) (USD $)
Sep. 30, 2017
Dec. 31, 2016
Preferred Stock, Par or Stated Value Per Share
$ 0.0001 
$ 0.0001 
Preferred Stock, Shares Authorized
5,000,000 
5,000,000 
Preferred Stock, Shares Issued
Preferred Stock, Shares Outstanding
Common Stock, Par or Stated Value Per Share
$ 0.0001 
$ 0.0001 
Common Stock, Shares Authorized
50,000,000 
50,000,000 
Common Stock, Shares, Issued
11,690,329 
11,690,329 
Common Stock, Shares, Outstanding
11,690,329 
11,690,329 
Consolidated Statements of Operations (USD $)
In Thousands, except Per Share data, unless otherwise specified
3 Months Ended 9 Months Ended
Sep. 30, 2017
Sep. 30, 2016
Sep. 30, 2017
Sep. 30, 2016
Operating expenses
 
 
 
 
Research and development
$ 1,729 
$ 1,787 
$ 6,310 
$ 4,637 
General and administrative
806 
1,351 
3,460 
2,910 
Noncash financial advising fees
7,515 
Total operating expenses
2,535 
3,138 
9,770 
15,062 
Loss from operations
(2,535)
(3,138)
(9,770)
(15,062)
Other income (expense)
 
 
 
 
Interest income
16 
28 
63 
34 
Interest expense
(231)
(233)
(707)
(1,822)
Other income, net
190 
Total other income (expense)
(215)
(205)
(644)
(1,598)
Net loss attributable to common stockholders
$ (2,750)
$ (3,343)
$ (10,414)
$ (16,660)
Net loss per share attributable to common stockholders, basic and diluted
$ (0.23)
$ (0.29)
$ (0.89)
$ (2.72)
Shares used in computation of basic and diluted net loss per share attributable to common stockholders
11,690 
11,690 
11,690 
6,120 
Consolidated Statements of Comprehensive Loss (USD $)
In Thousands, unless otherwise specified
3 Months Ended 9 Months Ended
Sep. 30, 2017
Sep. 30, 2016
Sep. 30, 2017
Sep. 30, 2016
Net loss
$ (2,750)
$ (3,343)
$ (10,414)
$ (16,660)
Other comprehensive income:
 
 
 
 
Unrealized gain (loss) on marketable securities
(1)
(3)
(3)
11 
Comprehensive loss
$ (2,751)
$ (3,346)
$ (10,417)
$ (16,649)
Consolidated Statements of Cash Flows (USD $)
In Thousands, unless otherwise specified
9 Months Ended
Sep. 30, 2017
Sep. 30, 2016
Operating activities
 
 
Net loss
$ (10,414)
$ (16,660)
Adjustments to reconcile net loss to net cash used in operating activities:
 
 
Noncash financial advising fees
7,515 
Amortization of debt discount
270 
1,518 
Depreciation and amortization
62 
115 
Stock-based compensation
819 
622 
Noncash interest expense
124 
Preferred stock warrant liability
(190)
Changes in operating assets and liabilities
 
 
Prepaids and other current assets
126 
(45)
Accounts payable
41 
137 
Accrued liabilities
(591)
226 
Deferred rent
(39)
Net cash used in operating activities
(9,687)
(6,677)
Investing activities
 
 
Purchases of marketable securities
(5,432)
(9,984)
Maturities of marketable securities
10,925 
Purchases of property and equipment
(157)
Net cash provided by (used in) investing activities
5,493 
(10,141)
Financing activities
 
 
Proceeds from issuance of common stock, net of issuance costs
16,475 
Proceeds from issuance of term loan, net of issuance costs
5,693 
Payment of term loan principal
(532)
Proceeds from issuance of original issue discount promissory note
400 
Payment of original issue discount promissory note
(400)
Net cash provided by (used in) financing activities
(532)
22,168 
Net increase (decrease) in cash and cash equivalents
(4,726)
5,350 
Cash and cash equivalents
 
 
Beginning of period
9,983 
3,290 
End of period
5,257 
8,640 
Noncash investing and financing activities:
 
 
Accretion of Series A preferred stock
Cash paid during the period for interest
439 
Conversion of preferred stock into common stock
25,716 
Debt discount for beneficial conversion feature on bridge loan
1,021 
Warrant liability reclassified to equity upon expiration
535 
Debt discount for warrant issued in connection with term loan payable
205 
Notes Payable, Other Payables [Member]
 
 
Noncash investing and financing activities:
 
 
Conversion of debt instrument into common stock
19,404 
Bridge Loan [Member]
 
 
Noncash investing and financing activities:
 
 
Conversion of debt instrument into common stock
$ 0 
$ 4,086 
Business and Basis of Presentation
Organization, Consolidation and Presentation of Financial Statements Disclosure [Text Block]
1. Business and Basis of Presentation
 
PhaseRx, Inc. (referred to as “PhaseRx”, the “Company,” “we,” “us,” or “our”) was incorporated in the State of Delaware on March 9, 2006 and is located in Seattle, Washington. We are a biopharmaceutical company developing a portfolio of products for the treatment of inherited enzyme deficiencies in the liver using intracellular enzyme replacement therapy, or i-ERT. Our i-ERT approach is enabled by our proprietary Hybrid messenger RNA, or mRNA, Technology platform, which allows synthesis of the missing enzyme inside the cell. Our initial product portfolio targets the three urea cycle disorders ornithine transcarbamylase deficiency, or OTCD, argininosuccinate lyase deficiency, or ASL deficiency, and argininosuccinate synthetase deficiency, or ASS1 deficiency.
 
Liquidity
 
We have financed our operations since inception primarily through the sale of preferred and common stock and the issuance of convertible notes and term loans. On October 13, 2017, we announced that we would be reducing costs and seeking a strategic partner for the Company’s assets. 
 
We believe our cash and cash equivalents balance of $5.3 million at September 30, 2017, is sufficient to fund our operations through February 2018. On October 12, 2017, we conducted a reduction in our workforce to reduce operating costs and conserve cash resources while we pursue strategic options for our research and development assets. Under this plan, which was completed in October 2017, we reduced our workforce by 10 employees (or 50%), including some executive officers. As a part of the reduction in workforce, we also announced that we will delay the development of our lead product candidate PRX-OTC. We are exploring various strategic alternatives, including but not limited to a potential merger transaction. However, no decision has been made as to whether we will engage in a transaction or transactions and there can be no assurance that the review of strategic alternatives will result in a transaction, or the terms or timing of any potential transaction that may take place. The Company may need to obtain additional equity and/or debt financing, especially if the Company is not able to consummate a potential transaction in a timely basis.  If the Company attempts to obtain additional equity or debt financing, the Company cannot assume that such financing will be available to the Company on favorable terms, or at all.
 
We anticipate that we will continue to incur losses for the foreseeable future. Our expected recurring losses and negative cash flows from operations raise substantial doubt about our ability to continue as a going concern.The consolidated financial statements do not include any adjustments related to the recoverability and classification of recorded asset amounts or to the amounts and classification of liabilities that might be necessary should the Company be unable to continue as a going concern.
 
On August 22, 2017, we received a letter from The Nasdaq Capital Market (“Nasdaq”) indicating that we no longer comply with the minimum stockholders’ equity requirement. In accordance with Nasdaq Listing Rules we had 45 calendar days to submit a plan to regain compliance. On September 21, 2017, we submitted a plan of compliance to the Nasdaq. On October 23, 2017, we were notified by Nasdaq that the staff has rejected our plan of compliance and initiated immediate delisting procedures for our common stock from Nasdaq.We are currently appealing this decision.  
 
Basis of Presentation
   
The accompanying interim consolidated financial statements are unaudited. The accompanying unaudited consolidated financial statements reflect, in the opinion of our management, all adjustments, consisting of only normal recurring adjustments, necessary for a fair presentation of financial position, results of operations, comprehensive loss and cash flows for each period presented in accordance with United States generally accepted accounting principles (“GAAP”) for interim financial information and with the instructions to Form 10-Q and Article 10 of Regulation S-X. Accordingly, certain information and disclosures normally included in financial statements prepared in accordance with GAAP have been condensed or omitted from the accompanying consolidated statements. These interim consolidated financial statements should be read in conjunction with the audited consolidated financial statements and related notes thereto included in our 2016 annual report on the Form 10-K. The accompanying consolidated financial information as of December 31, 2016 has been derived from the audited 2016 consolidated financial statements included in our 2016 annual report on the Form 10-K filed with the Securities and Exchange Commission on March 27, 2017. Operating results for the three and nine months ended September 30, 2017 are not necessarily indicative of results that may be expected for the year ending December 31, 2017, or any other future period.
Summary of Significant Accounting Policies
Significant Accounting Policies [Text Block]
2. Summary of Significant Accounting Policies
 
Principles of Consolidation
 
The consolidated financial statements include the accounts of PhaseRx and its wholly owned subsidiary, PhaseRx Ireland Limited. All material intercompany transactions and balances have been eliminated in consolidation.
  
Use of Estimates
 
The preparation of consolidated financial statements in conformity with GAAP requires our management to make estimates and assumptions that affect the reported amount of assets, liabilities, revenue and expenses, and related disclosure of contingent assets and liabilities. Actual results could differ from those estimates.
 
In preparing these consolidated financial statements, management has made its best estimates and judgments of certain amounts included in the consolidated financial statements, giving due consideration to materiality. On an ongoing basis, we evaluate our estimates, including those related to revenue recognition, fair value measurements, financing activities, accruals and other contingencies.
 
Cash Equivalents and Marketable Securities
 
We invest our excess cash in investment grade short- to intermediate-term fixed income securities. Such investments are included in cash and cash equivalents or marketable securities, on the balance sheets, classified as available-for-sale and reported at fair value with unrealized gains and losses included in accumulated other comprehensive income (loss). Realized gains and losses on the sale of these securities are recognized in net income or loss. We consider all highly liquid investments with original maturities at purchase of 90 days or less to be cash equivalents, an investment with a maturity greater than twelve months from the balance sheet date as long-term marketable securities and a maturity less than twelve months as short-term at the balance sheet date. Our cash equivalents and marketable securities consist principally of commercial paper and money market securities.
 
Interest earned on securities is included in interest income. Gains are recognized when realized in our statements of operations. Losses are recognized when realized or when we have determined that an other-than-temporary decline in fair value has occurred. The cost of securities sold is based on the specific identification method.
 
We periodically evaluate whether declines in fair values of our investments below their cost are other-than-temporary. This evaluation consists of several qualitative and quantitative factors regarding the severity and duration of the unrealized loss as well as our ability and intent to hold the investment until a forecasted recovery occurs. Factors considered include quoted market prices, recent financial results and operating trends, credit quality of debt instrument issuers, other publicly available information that may affect the value of our investments, duration and severity of the decline in value, and our strategy and intentions for holding the investment. Additionally, we assess whether it is more likely than not we will be required to sell any investment before recovery of its amortized cost basis.
 
Fair Value of Financial Instruments
 
We establish the fair value of our assets and liabilities using the price that would be received to sell an asset or paid to transfer a liability in an orderly transaction between market participants at the measurement date. We established a fair value hierarchy based on the inputs used to measure fair value. The three levels of the fair value hierarchy are as follows:
 
Level 1:  Quoted prices in active markets for identical assets or liabilities.
 
Level 2:  Inputs, other than the quoted prices in active markets that are observable either directly or indirectly.
 
Level 3:  Unobservable inputs in which little or no market data exists, therefore determined using estimates and assumptions developed by us, which reflect those that a market participant would use.
  
We measure and report at fair value our cash equivalents and marketable securities. The carrying value of accounts payable and accrued liabilities approximate their respective fair values due to their relative short maturities. The carrying value of our Hercules term loan approximates fair value because the interest rate is reflective of the rate we could obtain on debt with similar terms and conditions.
  
We may apply the fair value option to any eligible financial assets or liabilities, which permits an instrument by instrument irrevocable election to account for selected financial assets and liabilities at fair value. To date, we have not applied this election.
 
Research and Development Costs
 
Research and development costs are expensed as incurred. Research and development costs include salaries and personnel-related costs, consulting fees, fees paid for contract research services, the costs of laboratory supplies, equipment and facilities, license fees and other external costs. Non-refundable advance payments for goods or services to be received in the future for use in research and development activities are deferred and capitalized. The capitalized amounts are expensed as the related goods are delivered or the services are performed.
 
Stock-Based Compensation
  
We expense the cost of employee services received in exchange for an award of equity instruments based on the grant date fair value of such instruments. We use the Black-Scholes option pricing model to calculate the fair value of any equity instruments on the grant date. We recognize stock-based compensation on the graded-vesting method as expense over the requisite service period. The use of the Black-Scholes option pricing model requires management to make assumptions with respect to volatility, expected option term and, prior to the initial public offering (“IPO”), the fair value of our common stock. Measurement of stock-based compensation for options granted to nonemployees is subject to periodic adjustment as the underlying equity instruments vest.  
 
We have granted stock options with performance conditions to certain executive officers, directors and nonemployee consultants. At each reporting date, we evaluate whether the achievement of the performance conditions is probable. Compensation expense is recorded over the appropriate service period based upon our assessment of achievement of each performance condition or the occurrence of the event which will trigger the options to vest.
 
Comprehensive Loss
 
Comprehensive loss is comprised of net loss and other comprehensive income or loss. Other comprehensive income or loss consists of unrealized gains and losses on marketable securities.
 
Net Loss Per Share
  
The computation of basic and diluted net loss per share attributable to common stockholders is calculated by dividing net loss attributable to common stockholders by the weighted average shares outstanding during the period and excludes all outstanding stock options and warrants from the calculation of diluted net loss per common share, as all such securities are anti-dilutive to the computation for all the periods presented. For the three and nine months ended September 30, 2017, the computation of diluted net loss per share excluded 2,111,619 shares. For the three and nine months ended September 30, 2016, the computation of diluted net loss per share excluded 1,446,658 shares.
 
The following table presents the calculation of basic and diluted net loss per share attributable to common stockholders (in thousands, except per share amounts):
 
 
 
Three Months Ended
September 30,
 
Nine Months Ended 
September 30,
 
 
 
2017
 
2016
 
2017
 
2016
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Net loss attributable to common stockholders
 
$
(2,750)
 
$
(3,343)
 
$
(10,414)
 
$
(16,660)
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Weighted average shares used in computation of basic and diluted net loss per share attributable to common stockholders
 
 
11,690
 
 
11,690
 
 
11,690
 
 
6,120
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Basic and diluted net loss per share attributable to common stockholders
 
$
(0.23)
 
$
(0.29)
 
$
(0.89)
 
$
(2.72)
 
    
Concentration of Risk
 
We maintain our cash, cash equivalents and investments with high quality, accredited financial institutions. These amounts at times may exceed federally insured limits. We have not experienced any credit losses in such accounts and do not believe we are exposed to significant risk on these funds. Our cash and cash equivalents balances of $5.0 million and $9.8 million as of September 30, 2017 and December 31, 2016, respectively, were uninsured.
 
Recent Accounting Pronouncements
 
In February 2016, the FASB issued ASU 2016-02, Leases (Topic 842). The ASU is intended to provide more transparent and economically neutral information about the assets and liabilities that arise from leases than previous guidance. The ASU is effective for public entities for annual periods beginning on or after December 15, 2018. Early adoption is permitted, and adoption must be applied on a modified retrospective basis. We are evaluating the impact of this guidance on our financial statements.
  
In June 2016, the FASB issued ASU 2016-13, Financial Instruments: Credit Losses that changes the impairment model for most financial instruments, including trade receivables from an incurred loss method to a new forward-looking approach, based on expected losses. The estimate of expected credit losses will require entities to incorporate considerations of historical information, current information and reasonable and supportable forecasts. This ASU is effective for us in the first quarter of 2020 and must be adopted using a modified retrospective transition approach. We are evaluating the impact of this guidance but do not expect that the adoption will have a material impact on our financial statements.
  
In August 2016, the FASB issued ASU 2016-15, Statement of Cash Flows: Classification of Certain Cash Receipts and Cash Payments that clarifies how certain cash receipts and cash payments are presented and classified in the statement of cash flows. The ASU is effective for us in the first quarter of 2018 with early adoption permitted and must be applied retrospectively to all periods presented. We are evaluating the impact of this guidance but do not expect that the adoption will have a material impact on our financial statements.
   
In May 2017, the FASB issued ASU 2017-09, Compensation – Stock Compensation , which is intended to provide clarity and reduce diversity in practice as well as cost and complexity when applying the guidance to a change to the terms or conditions of a share-based payment award. This ASU is effective for annual reporting periods beginning after December 15, 2017 and interim periods within those fiscal years with early adoption permitted. We are evaluating the impact of this guidance but do not expect that the adoption will have a material impact on our financial statements.
Term Loan
Debt Disclosure [Text Block]
3. Term Loan
 
On June 7, 2016, we entered into a Loan and Security Agreement (the “Loan Agreement”) by and among us, the several banks and other financial institutions or entities from time to time parties to the Loan Agreement (the “Lenders”) and Hercules Capital, Inc. (“Hercules”), in its capacity as administrative agent for itself and the Lenders, pursuant to which the Lenders funded $6 million to us (the “Term Loan”). The Term Loan is secured by substantially all of our assets other than our intellectual property.
 
The Term Loan bears interest at a floating annual rate equal to the greater of (i) 9.25% and (ii) the sum of (a) 9.25%, plus (b) the prime rate as reported by The Wall Street Journal minus 3.50%, resulting in a rate of 10.00% as of September 30, 2017. We are required to make interest payments in cash on the first business day of each month, beginning on July 1, 2016. The Term Loan began amortizing on July 3, 2017, in equal monthly installments of principal and interest, with such payments beginning on July 3, 2017, and continuing on the first business day of each month thereafter until the Term Loan is repaid. The final maturity date of the Term Loan is December 2, 2019. Upon repayment of the term loan, we are required to pay an end of term charge to the Lenders equal to 5.85% of the aggregate original principal amount of all Term Loan advances extended by the Lenders to us.
 
At our option, we may prepay all or any portion of the outstanding principal balance and all accrued and unpaid interest with respect to the principal balance being prepaid of the Term Loan, subject to a prepayment fee of 2% of the amount prepaid if the prepayment occurs after June 7, 2017 but on or prior to June 7, 2018, or 1% of the amount prepaid if the prepayment occurs after June 7, 2018.
 
In connection with the Loan Agreement, we also issued to Hercules Technology III, L.P., as the sole Lender on June 7, 2016, a warrant to purchase up to 63,000 shares of common stock at an exercise price of $5.00 per share. The warrant may be exercised either for cash or on a cashless “net exercise” basis. The warrant is immediately exercisable and expires on June 7, 2021.
 
The total debt discount, inclusive of the end of term charge and other fees, amounted to $659,000 related to this Term Loan is being amortized to interest expense over the term of the Term Loan.
Fair Value Measurements
Fair Value Disclosures [Text Block]
4. Fair Value Measurements
 
The following table sets forth the fair value of our assets measured at fair value at September 30, 2017 and December 31, 2016 (in thousands):
  
 
 
September 30, 2017
 
Description
 
Balance
 
Quoted Prices in
Active Markets
for
Identical Assets
(Level 1)
 
Significant Other
Observable
Inputs
(Level 2)
 
Significant
Unobservable
Inputs
(Level 3)
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Money market
 
$
4,083
 
$
4,083
 
$
-
 
$
-
 
Commercial paper
 
 
500
 
 
-
 
 
500
 
 
-
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Total financial assets
 
$
4,583
 
$
4,083
 
$
500
 
$
-
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Add Cash:
 
 
674
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Total cash, cash equivalents and marketable securities
 
$
5,257
 
 
 
 
 
 
 
 
 
 
 
 
 
December 31, 2016
 
Description
 
Balance
 
Quoted Prices in
Active Markets
for
Identical Assets
(Level 1)
 
Significant
Other
Observable
Inputs
(Level 2)
 
Significant
Unobservable
Inputs
(Level 3)
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Money market
 
$
7,731
 
$
7,731
 
$
-
 
$
-
 
Commercial paper
 
 
7,544
 
 
-
 
 
7,544
 
 
-
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Total financial assets
 
$
15,275
 
$
7,731
 
$
7,544
 
$
-
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Add Cash:
 
 
204
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Total cash, cash equivalents and marketable securities
 
$
15,479
 
 
 
 
 
 
 
 
 
 
Stock-Based Compensation
Disclosure of Compensation Related Costs, Share-based Payments [Text Block]
5. Stock-Based Compensation  
 
We granted incentive stock options to employees and nonqualified stock options to members of the board of directors for their services on the board of directors and to nonemployee consultants for their consulting services. Options, in general, either vest in 48 equal monthly installments or 25% on the first year anniversary and 1/48 th of the granted options monthly thereafter, such that options are fully vested on the four-year anniversary of the date of grant.
 
 
 
 
 
 
 
 
 
Weighted
 
 
 
 
 
 
 
 
 
 
 
 
Average
 
Average
 
 
 
 
 
 
Weighted
 
Remaining
 
Intrinsic
 
 
 
Number of
 
Average
 
Contractual
 
Value
 
 
 
Stock Options
 
Exercise Price
 
Life
 
(in thousands)
 
Outstanding as of December 31, 2016
 
 
1,751,473
 
$
2.54
 
 
 
 
 
 
 
Options granted
 
 
401,000
 
 
1.27
 
 
 
 
 
 
 
Options forfeited
 
 
(117,987)
 
 
2.85
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Outstanding at September 30, 2017
 
 
2,034,486
 
$
2.28
 
 
7.98
 
$
181
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Exercisable at September 30, 2017
 
 
822,781
 
$
2.12
 
 
6.53
 
$
143
 
  
At September 30, 2017, we had unrecognized compensation cost of $916,000 which will be recognized over the weighted-average remaining service period of approximately 2.0 years.
  
Stock-based compensation expense has been included in the Statement of Operations as follows (in thousands):
  
 
 
Three months ended September 30
 
Nine months ended September 30
 
 
 
2017
 
2016
 
2017
 
2016
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Research and development
 
$
77
 
$
167
 
$
281
 
$
197
 
General and administrative
 
 
144
 
 
299
 
 
538
 
 
425
 
 
 
$
221
 
$
466
 
$
819
 
$
622
 
 
The fair value of the stock options was estimated at the date of grant using the Black-Scholes option-pricing model with the following weighted average assumptions during the nine months ended September 30, 2017 and 2016:
 
 
 
Nine Months
Ended
 
 
Nine Months
Ended
 
 
 
September 30,
2017
 
 
September 30,
2016
 
 
 
 
 
 
 
 
 
 
Weighted average estimated fair value per share
 
$
0.75
 
 
$
2.60
 
 
 
 
 
 
 
 
 
 
Weighted average assumptions:
 
 
 
 
 
 
 
 
Dividend yields
 
 
-
 
 
 
-
 
Expected term (years)
 
 
5.7
 
 
 
5.9
 
Risk free interest rate
 
 
1.9
%
 
 
1.4
%
Volatility
 
 
80.3
%
 
 
80.3
%
 
The risk-free interest rates used in the Black-Scholes option pricing model are based on the implied yield currently available in United States Treasury securities at maturity with an equivalent term. We have limited stock option exercise information. Accordingly, the expected term of stock options granted was calculated using the simplified method, which represents the average of the contractual term of the stock option and the weighted-average vesting period of the stock option. We have not declared or paid any dividends and do not currently expect to do so in the foreseeable future. The value of our underlying common stock was determined by the board of directors, which relied in part upon the report of third party valuation specialists and input from our management prior to the IPO. Expected volatility is based on an average volatility of stock prices for a group of similar publicly traded companies. The fair value of each stock option award is estimated on the date of grant using the Black-Scholes option pricing model.
Summary of Significant Accounting Policies (Policies)
Principles of Consolidation
 
The consolidated financial statements include the accounts of PhaseRx and its wholly owned subsidiary, PhaseRx Ireland Limited. All material intercompany transactions and balances have been eliminated in consolidation.
Use of Estimates
 
The preparation of consolidated financial statements in conformity with GAAP requires our management to make estimates and assumptions that affect the reported amount of assets, liabilities, revenue and expenses, and related disclosure of contingent assets and liabilities. Actual results could differ from those estimates.
 
In preparing these consolidated financial statements, management has made its best estimates and judgments of certain amounts included in the consolidated financial statements, giving due consideration to materiality. On an ongoing basis, we evaluate our estimates, including those related to revenue recognition, fair value measurements, financing activities, accruals and other contingencies.
Cash Equivalents and Marketable Securities
 
We invest our excess cash in investment grade short- to intermediate-term fixed income securities. Such investments are included in cash and cash equivalents or marketable securities, on the balance sheets, classified as available-for-sale and reported at fair value with unrealized gains and losses included in accumulated other comprehensive income (loss). Realized gains and losses on the sale of these securities are recognized in net income or loss. We consider all highly liquid investments with original maturities at purchase of 90 days or less to be cash equivalents, an investment with a maturity greater than twelve months from the balance sheet date as long-term marketable securities and a maturity less than twelve months as short-term at the balance sheet date. Our cash equivalents and marketable securities consist principally of commercial paper and money market securities.
 
Interest earned on securities is included in interest income. Gains are recognized when realized in our statements of operations. Losses are recognized when realized or when we have determined that an other-than-temporary decline in fair value has occurred. The cost of securities sold is based on the specific identification method.
 
We periodically evaluate whether declines in fair values of our investments below their cost are other-than-temporary. This evaluation consists of several qualitative and quantitative factors regarding the severity and duration of the unrealized loss as well as our ability and intent to hold the investment until a forecasted recovery occurs. Factors considered include quoted market prices, recent financial results and operating trends, credit quality of debt instrument issuers, other publicly available information that may affect the value of our investments, duration and severity of the decline in value, and our strategy and intentions for holding the investment. Additionally, we assess whether it is more likely than not we will be required to sell any investment before recovery of its amortized cost basis.
Fair Value of Financial Instruments
 
We establish the fair value of our assets and liabilities using the price that would be received to sell an asset or paid to transfer a liability in an orderly transaction between market participants at the measurement date. We established a fair value hierarchy based on the inputs used to measure fair value. The three levels of the fair value hierarchy are as follows:
 
Level 1:  Quoted prices in active markets for identical assets or liabilities.
 
Level 2:  Inputs, other than the quoted prices in active markets that are observable either directly or indirectly.
 
Level 3:  Unobservable inputs in which little or no market data exists, therefore determined using estimates and assumptions developed by us, which reflect those that a market participant would use.
  
We measure and report at fair value our cash equivalents and marketable securities. The carrying value of accounts payable and accrued liabilities approximate their respective fair values due to their relative short maturities. The carrying value of our Hercules term loan approximates fair value because the interest rate is reflective of the rate we could obtain on debt with similar terms and conditions.
  
We may apply the fair value option to any eligible financial assets or liabilities, which permits an instrument by instrument irrevocable election to account for selected financial assets and liabilities at fair value. To date, we have not applied this election.
Research and Development Costs
 
Research and development costs are expensed as incurred. Research and development costs include salaries and personnel-related costs, consulting fees, fees paid for contract research services, the costs of laboratory supplies, equipment and facilities, license fees and other external costs. Non-refundable advance payments for goods or services to be received in the future for use in research and development activities are deferred and capitalized. The capitalized amounts are expensed as the related goods are delivered or the services are performed.
Stock-Based Compensation
  
We expense the cost of employee services received in exchange for an award of equity instruments based on the grant date fair value of such instruments. We use the Black-Scholes option pricing model to calculate the fair value of any equity instruments on the grant date. We recognize stock-based compensation on the graded-vesting method as expense over the requisite service period. The use of the Black-Scholes option pricing model requires management to make assumptions with respect to volatility, expected option term and, prior to the initial public offering (“IPO”), the fair value of our common stock. Measurement of stock-based compensation for options granted to nonemployees is subject to periodic adjustment as the underlying equity instruments vest.  
 
We have granted stock options with performance conditions to certain executive officers, directors and nonemployee consultants. At each reporting date, we evaluate whether the achievement of the performance conditions is probable. Compensation expense is recorded over the appropriate service period based upon our assessment of achievement of each performance condition or the occurrence of the event which will trigger the options to vest.
Comprehensive Loss
 
Comprehensive loss is comprised of net loss and other comprehensive income or loss. Other comprehensive income or loss consists of unrealized gains and losses on marketable securities.
Net Loss Per Share
  
The computation of basic and diluted net loss per share attributable to common stockholders is calculated by dividing net loss attributable to common stockholders by the weighted average shares outstanding during the period and excludes all outstanding stock options and warrants from the calculation of diluted net loss per common share, as all such securities are anti-dilutive to the computation for all the periods presented. For the three and nine months ended September 30, 2017, the computation of diluted net loss per share excluded 2,111,619 shares. For the three and nine months ended September 30, 2016, the computation of diluted net loss per share excluded 1,446,658 shares.
 
The following table presents the calculation of basic and diluted net loss per share attributable to common stockholders (in thousands, except per share amounts):
 
 
 
Three Months Ended
September 30,
 
Nine Months Ended 
September 30,
 
 
 
2017
 
2016
 
2017
 
2016
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Net loss attributable to common stockholders
 
$
(2,750)
 
$
(3,343)
 
$
(10,414)
 
$
(16,660)
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Weighted average shares used in computation of basic and diluted net loss per share attributable to common stockholders
 
 
11,690
 
 
11,690
 
 
11,690
 
 
6,120
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Basic and diluted net loss per share attributable to common stockholders
 
$
(0.23)
 
$
(0.29)
 
$
(0.89)
 
$
(2.72)
 
Concentration of Risk
 
We maintain our cash, cash equivalents and investments with high quality, accredited financial institutions. These amounts at times may exceed federally insured limits. We have not experienced any credit losses in such accounts and do not believe we are exposed to significant risk on these funds. Our cash and cash equivalents balances of $5.0 million and $9.8 million as of September 30, 2017 and December 31, 2016, respectively, were uninsured.
Recent Accounting Pronouncements
 
In February 2016, the FASB issued ASU 2016-02, Leases (Topic 842). The ASU is intended to provide more transparent and economically neutral information about the assets and liabilities that arise from leases than previous guidance. The ASU is effective for public entities for annual periods beginning on or after December 15, 2018. Early adoption is permitted, and adoption must be applied on a modified retrospective basis. We are evaluating the impact of this guidance on our financial statements.
  
In June 2016, the FASB issued ASU 2016-13, Financial Instruments: Credit Losses that changes the impairment model for most financial instruments, including trade receivables from an incurred loss method to a new forward-looking approach, based on expected losses. The estimate of expected credit losses will require entities to incorporate considerations of historical information, current information and reasonable and supportable forecasts. This ASU is effective for us in the first quarter of 2020 and must be adopted using a modified retrospective transition approach. We are evaluating the impact of this guidance but do not expect that the adoption will have a material impact on our financial statements.
  
In August 2016, the FASB issued ASU 2016-15, Statement of Cash Flows: Classification of Certain Cash Receipts and Cash Payments that clarifies how certain cash receipts and cash payments are presented and classified in the statement of cash flows. The ASU is effective for us in the first quarter of 2018 with early adoption permitted and must be applied retrospectively to all periods presented. We are evaluating the impact of this guidance but do not expect that the adoption will have a material impact on our financial statements.
   
In May 2017, the FASB issued ASU 2017-09, Compensation – Stock Compensation , which is intended to provide clarity and reduce diversity in practice as well as cost and complexity when applying the guidance to a change to the terms or conditions of a share-based payment award. This ASU is effective for annual reporting periods beginning after December 15, 2017 and interim periods within those fiscal years with early adoption permitted. We are evaluating the impact of this guidance but do not expect that the adoption will have a material impact on our financial statements.
Summary of Significant Accounting Policies (Tables)
Schedule of Earnings Per Share, Basic and Diluted [Table Text Block]
The following table presents the calculation of basic and diluted net loss per share attributable to common stockholders (in thousands, except per share amounts):
 
 
 
Three Months Ended
September 30,
 
Nine Months Ended 
September 30,
 
 
 
2017
 
2016
 
2017
 
2016
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Net loss attributable to common stockholders
 
$
(2,750)
 
$
(3,343)
 
$
(10,414)
 
$
(16,660)
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Weighted average shares used in computation of basic and diluted net loss per share attributable to common stockholders
 
 
11,690
 
 
11,690
 
 
11,690
 
 
6,120
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Basic and diluted net loss per share attributable to common stockholders
 
$
(0.23)
 
$
(0.29)
 
$
(0.89)
 
$
(2.72)
 
Fair Value Measurements (Tables)
Fair Value Measurements, Recurring and Nonrecurring [Table Text Block]
The following table sets forth the fair value of our assets measured at fair value at September 30, 2017 and December 31, 2016 (in thousands):
  
 
 
September 30, 2017
 
Description
 
Balance
 
Quoted Prices in
Active Markets
for
Identical Assets
(Level 1)
 
Significant Other
Observable
Inputs
(Level 2)
 
Significant
Unobservable
Inputs
(Level 3)
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Money market
 
$
4,083
 
$
4,083
 
$
-
 
$
-
 
Commercial paper
 
 
500
 
 
-
 
 
500
 
 
-
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Total financial assets
 
$
4,583
 
$
4,083
 
$
500
 
$
-
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Add Cash:
 
 
674
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Total cash, cash equivalents and marketable securities
 
$
5,257
 
 
 
 
 
 
 
 
 
 
 
 
 
December 31, 2016
 
Description
 
Balance
 
Quoted Prices in
Active Markets
for
Identical Assets
(Level 1)
 
Significant
Other
Observable
Inputs
(Level 2)
 
Significant
Unobservable
Inputs
(Level 3)
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Money market
 
$
7,731
 
$
7,731
 
$
-
 
$
-
 
Commercial paper
 
 
7,544
 
 
-
 
 
7,544
 
 
-
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Total financial assets
 
$
15,275
 
$
7,731
 
$
7,544
 
$
-
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Add Cash:
 
 
204
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Total cash, cash equivalents and marketable securities
 
$
15,479
 
 
 
 
 
 
 
 
 
 
Stock-Based Compensation (Tables)
 
 
 
 
 
 
 
 
Weighted
 
 
 
 
 
 
 
 
 
 
 
 
Average
 
Average
 
 
 
 
 
 
Weighted
 
Remaining
 
Intrinsic
 
 
 
Number of
 
Average
 
Contractual
 
Value
 
 
 
Stock Options
 
Exercise Price
 
Life
 
(in thousands)
 
Outstanding as of December 31, 2016
 
 
1,751,473
 
$
2.54
 
 
 
 
 
 
 
Options granted
 
 
401,000
 
 
1.27
 
 
 
 
 
 
 
Options forfeited
 
 
(117,987)
 
 
2.85
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Outstanding at September 30, 2017
 
 
2,034,486
 
$
2.28
 
 
7.98
 
$
181
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Exercisable at September 30, 2017
 
 
822,781
 
$
2.12
 
 
6.53
 
$
143
 
Stock-based compensation expense has been included in the Statement of Operations as follows (in thousands):
  
 
 
Three months ended September 30
 
Nine months ended September 30
 
 
 
2017
 
2016
 
2017
 
2016
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Research and development
 
$
77
 
$
167
 
$
281
 
$
197
 
General and administrative
 
 
144
 
 
299
 
 
538
 
 
425
 
 
 
$
221
 
$
466
 
$
819
 
$
622
 
The fair value of the stock options was estimated at the date of grant using the Black-Scholes option-pricing model with the following weighted average assumptions during the nine months ended September 30, 2017 and 2016:
 
 
 
Nine Months
Ended
 
 
Nine Months
Ended
 
 
 
September 30,
2017
 
 
September 30,
2016
 
 
 
 
 
 
 
 
 
 
Weighted average estimated fair value per share
 
$
0.75
 
 
$
2.60
 
 
 
 
 
 
 
 
 
 
Weighted average assumptions:
 
 
 
 
 
 
 
 
Dividend yields
 
 
-
 
 
 
-
 
Expected term (years)
 
 
5.7
 
 
 
5.9
 
Risk free interest rate
 
 
1.9
%
 
 
1.4
%
Volatility
 
 
80.3
%
 
 
80.3
%
Business and Basis of Presentation (Details Textual) (USD $)
In Thousands, unless otherwise specified
Sep. 30, 2017
Dec. 31, 2016
Sep. 30, 2016
Dec. 31, 2015
Cash and Cash Equivalents, at Carrying Value
$ 5,257 
$ 9,983 
$ 8,640 
$ 3,290 
Summary of Significant Accounting Policies (Details) (USD $)
In Thousands, except Per Share data, unless otherwise specified
3 Months Ended 9 Months Ended
Sep. 30, 2017
Sep. 30, 2016
Sep. 30, 2017
Sep. 30, 2016
Schedule Of Earnings Per Share Basic And Diluted [Line Items]
 
 
 
 
Net loss attributable to common stockholders
$ (2,750)
$ (3,343)
$ (10,414)
$ (16,660)
Weighted average shares used in computation of basic and diluted net loss per share attributable to common stockholders
11,690 
11,690 
11,690 
6,120 
Basic and diluted net loss per share attributable to common stockholders
$ (0.23)
$ (0.29)
$ (0.89)
$ (2.72)
Summary of Significant Accounting Policies (Details Textual) (USD $)
In Thousands, except Share data, unless otherwise specified
3 Months Ended 9 Months Ended
Sep. 30, 2017
Sep. 30, 2016
Sep. 30, 2017
Sep. 30, 2016
Dec. 31, 2016
Dec. 31, 2015
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount
2,111,619 
1,446,658 
2,111,619 
1,446,658 
 
 
Cash and Cash Equivalents, at Carrying Value
$ 5,257 
$ 8,640 
$ 5,257 
$ 8,640 
$ 9,983 
$ 3,290 
Term Loan (Details Textual) (USD $)
9 Months Ended
Sep. 30, 2017
Jun. 7, 2016
Debt Instrument, Interest Rate, Stated Percentage
10.00% 
 
Hercules Term Loan [Member]
 
 
Debt instrument End of Term Loan Fee Percentage
5.85% 
 
Debt Instrument Prepayment Fee Percentage, If Paid within Twelve Months
2.00% 
 
Debt Instrument Prepayment Fee Percentage, If Paid After Two Years
1.00% 
 
Debt Instrument, Interest Rate Terms
greater of (i) 9.25% and (ii) the sum of (a) 9.25%, plus (b) the prime rate as reported by The Wall Street Journal minus 3.50% 
 
Class of Warrant or Right, Number of Securities Called by Warrants or Rights
 
63,000 
Class of Warrant or Right, Exercise Price of Warrants or Rights
 
$ 5.00 
Debt Instrument, Face Amount
 
$ 6,000,000 
Debt Instrument, Unamortized Discount
$ 659,000 
 
Hercules Term Loan [Member] |
Warrant [Member]
 
 
Debt Instrument, Maturity Date
Jun. 07, 2021 
 
Fair Value Measurements (Details) (USD $)
In Thousands, unless otherwise specified
Sep. 30, 2017
Dec. 31, 2016
Financial Assets:
 
 
Total financial assets
$ 4,583 
$ 15,275 
Add Cash:
674 
204 
Total cash, cash equivalents and marketable securities
5,257 
15,479 
Money Market Funds [Member]
 
 
Financial Assets:
 
 
Total financial assets
4,083 
7,731 
Commercial Paper [Member]
 
 
Financial Assets:
 
 
Total financial assets
500 
7,544 
Fair Value, Inputs, Level 1 [Member]
 
 
Financial Assets:
 
 
Total financial assets
4,083 
7,731 
Fair Value, Inputs, Level 1 [Member] |
Money Market Funds [Member]
 
 
Financial Assets:
 
 
Total financial assets
4,083 
7,731 
Fair Value, Inputs, Level 1 [Member] |
Commercial Paper [Member]
 
 
Financial Assets:
 
 
Total financial assets
Fair Value, Inputs, Level 2 [Member]
 
 
Financial Assets:
 
 
Total financial assets
500 
7,544 
Fair Value, Inputs, Level 2 [Member] |
Money Market Funds [Member]
 
 
Financial Assets:
 
 
Total financial assets
Fair Value, Inputs, Level 2 [Member] |
Commercial Paper [Member]
 
 
Financial Assets:
 
 
Total financial assets
500 
7,544 
Fair Value, Inputs, Level 3 [Member]
 
 
Financial Assets:
 
 
Total financial assets
Fair Value, Inputs, Level 3 [Member] |
Money Market Funds [Member]
 
 
Financial Assets:
 
 
Total financial assets
Fair Value, Inputs, Level 3 [Member] |
Commercial Paper [Member]
 
 
Financial Assets:
 
 
Total financial assets
$ 0 
$ 0 
Stock-Based Compensation (Details) (USD $)
In Thousands, except Share data, unless otherwise specified
9 Months Ended
Sep. 30, 2017
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
 
Number of Stock Options, Balance beginning of period
1,751,473 
Number of Stock Options, Options granted
401,000 
Number of Stock Options, Options forfeited
(117,987)
Number of Stock Options, Balance end of period
2,034,486 
Number of Stock Options, Exercisable - end of period
822,781 
Weighted Average Exercise Price, Outstanding
$ 2.54 
Weighted- Average Exercise Price, Options granted
$ 1.27 
Weighted-Average Exercise Price, Options forfeited
$ 2.85 
Weighted-Average Exercise Price, Outstanding
$ 2.28 
Weighted-Average Exercise Price, Exercisable - end of period
$ 2.12 
Weighted Average Remaining Contractual Life, Outstanding
7 years 11 months 23 days 
Weighted Average Remaining Contractual Life, Exercisable
6 years 6 months 11 days 
Average Intrinsic Value, Outstanding
$ 181 
Average Intrinsic Value, Exercisable
$ 143 
Stock-Based Compensation (Details 1) (USD $)
In Thousands, unless otherwise specified
3 Months Ended 9 Months Ended
Sep. 30, 2017
Sep. 30, 2016
Sep. 30, 2017
Sep. 30, 2016
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items]
 
 
 
 
Allocated Share-based Compensation Expense
$ 221 
$ 466 
$ 819 
$ 622 
Research and development [Member]
 
 
 
 
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items]
 
 
 
 
Allocated Share-based Compensation Expense
77 
167 
281 
197 
General and administrative [Member]
 
 
 
 
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items]
 
 
 
 
Allocated Share-based Compensation Expense
$ 144 
$ 299 
$ 538 
$ 425 
Stock-Based Compensation (Details 2)
9 Months Ended
Sep. 30, 2017
Sep. 30, 2016
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
 
 
Weighted average estimated fair value per share
$ 0.75 
$ 2.6 
Weighted average assumptions:
 
 
Dividend yields
0.00% 
0.00% 
Expected term (years)
5 years 8 months 12 days 
5 years 10 months 24 days 
Risk free interest rate
1.90% 
1.40% 
Volatility
80.30% 
80.30% 
Stock-Based Compensation (Details Textual) (USD $)
9 Months Ended
Sep. 30, 2017
Employee Service Share-based Compensation, Nonvested Awards, Compensation Not yet Recognized, Stock Options
$ 916,000 
Employee Service Share-based Compensation, Nonvested Awards, Compensation Cost Not yet Recognized, Period for Recognition
2 years 
Share-based Compensation Award, Tranche One [Member]
 
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Period
48 months 
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Rights, Percentage
25.00%