Document and Entity Information - shares	9 Months Ended
Document and Entity Information - shares	Sep. 30, 2019	Oct. 31, 2019
Cover [Abstract]
Entity Registrant Name	ACORDA THERAPEUTICS INC
Entity Central Index Key	0001008848
Document Type	10-Q
Document Period End Date	Sep. 30, 2019
Amendment Flag	false
Current Fiscal Year End Date	--12-31
Entity Filer Category	Large Accelerated Filer
Entity Current Reporting Status	Yes
Entity Interactive Data Current	Yes
Entity Small Business	false
Entity Emerging Growth Company	false
Entity Shell Company	false
Document Quarterly Report	true
Document Transition Report	false
Document Fiscal Year Focus	2019
Document Fiscal Period Focus	Q3
Trading Symbol	ACOR
Title of 12(b) Security	Common Stock $0.001 par value
Security Exchange Name	NASDAQ
Entity Common Stock, Shares Outstanding		48,030,198
Entity File Number	001-31938
Entity Incorporation, State or Country Code	DE
Entity Tax Identification Number	13-3831168
Entity Address, Address Line One	420 Saw Mill River Road
Entity Address, City or Town	Ardsley
Entity Address, State or Province	NY
Entity Address, Postal Zip Code	10502
City Area Code	914
Local Phone Number	347-4300

Consolidated Balance Sheets - USD ($) $ in Thousands	Sep. 30, 2019	Dec. 31, 2018
Current assets:
Cash and cash equivalents	$ 119,521	$ 293,564
Restricted cash	387	532
Short term investments	133,636	151,989
Trade accounts receivable, net of allowances of $886 and $2,681, as of September 30, 2019 and December 31, 2018, respectively	17,553	23,430
Prepaid expenses	11,839	19,384
Inventory, net	27,396	29,014
Other current assets	4,005	10,194
Total current assets	314,337	528,107
Property and equipment, net of accumulated depreciation	130,585	60,519
Goodwill	0	282,059
Intangible assets, net of accumulated amortization	410,023	428,570
Right of use assets	24,675
Other assets	293	411
Total assets	879,913	1,299,666
Current liabilities:
Accounts payable	26,777	48,859
Accrued expenses and other current liabilities	43,235	76,882
Current portion of acquired contingent consideration	3,887	4,914
Current portion of lease liabilities	7,696
Current portion of loans payable	587	616
Current portion of liability related to sale of future royalties	9,811	8,985
Total current liabilities	91,993	140,256
Convertible senior notes (due 2021)	326,381	318,670
Non-current portion of acquired contingent consideration	107,313	163,086
Non-current portion of lease liabilities	24,393
Non-current portion of loans payable	24,518	24,470
Deferred tax liability	2,804	7,483
Non-current portion of liability related to sale of future royalties	16,437	21,731
Other non-current liabilities	4,732	11,987
Commitments and contingencies
Stockholders’ equity:
Preferred stock, $0.001 par value. Authorized 20,000,000 shares at September 30, 2019 and December 31, 2018; no shares issued as of September 30, 2019 and December 31, 2018, respectively
Common stock, $0.001 par value. Authorized 80,000,000 shares at September 30, 2019 and December 31, 2018; issued 47,539,910 and 47,508,505 shares, including those held in treasury, as of September 30, 2019 and December 31, 2018, respectively	48	48
Treasury stock at cost (29,304 shares at September 30, 2019 and 87,737 shares at December 31, 2018)	(638)	(2,133)
Additional paid-in capital	1,015,037	1,005,105
Accumulated deficit	(732,469)	(393,843)
Accumulated other comprehensive (loss) income	(636)	2,806
Total stockholders’ equity	281,342	611,983
Total liabilities and stockholders’ equity	$ 879,913	$ 1,299,666

Consolidated Balance Sheets (Parenthetical) - USD ($) $ in Thousands	Sep. 30, 2019	Dec. 31, 2018
Statement Of Financial Position [Abstract]
Trade accounts receivable, allowances (in dollars)	$ 886	$ 2,681
Preferred stock, par value (in dollars per share)	$ 0.001	$ 0.001
Preferred stock, Authorized shares	20,000,000	20,000,000
Preferred stock, issued shares	0	0
Common stock, par value (in dollars per share)	$ 0.001	$ 0.001
Common stock, Authorized shares	80,000,000	80,000,000
Common stock, issued shares	47,539,910	47,508,505
Treasury stock, shares	29,304	87,737

Consolidated Statements of Operations - USD ($) shares in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2019	Sep. 30, 2018	Sep. 30, 2019	Sep. 30, 2018
Revenues:
Total net revenues	$ 47,722,000	$ 142,814,000	$ 141,911,000	$ 402,281,000
Costs and expenses:
Cost of sales	7,986,000	25,152,000	26,183,000	76,164,000
Research and development	16,073,000	22,855,000	51,060,000	79,325,000
Selling, general and administrative	48,702,000	43,571,000	151,622,000	135,435,000
Goodwill impairment	277,561,000		277,561,000
Amortization of intangible assets	7,692,000	239,000	17,945,000	1,670,000
Changes in fair value of acquired contingent consideration	(50,942,000)	22,700,000	(56,342,000)	21,900,000
Total operating expenses	307,072,000	114,517,000	468,029,000	314,494,000
Operating (loss) income	(259,350,000)	28,297,000	(326,118,000)	87,787,000
Other (expense) income, net:
Interest and amortization of debt discount expense	(4,500,000)	(5,415,000)	(16,302,000)	(16,326,000)
Interest income	333,000	1,176,000	3,327,000	2,412,000
Realized loss on foreign currency transactions	(1,000)	(1,000)	(17,000)	(8,000)
Other income				24,000
Total other expense, net	(4,168,000)	(4,240,000)	(12,992,000)	(13,898,000)
(Loss) income before taxes	(263,518,000)	24,057,000	(339,110,000)	73,889,000
Benefit from (Provision for) income taxes	(17,000)	(37,968,000)	484,000	(49,802,000)
Net (loss) income	$ (263,535,000)	$ (13,911,000)	$ (338,626,000)	$ 24,087,000
Net (loss) income per share—basic	$ (5.55)	$ (0.29)	$ (7.13)	$ 0.51
Net (loss) income per share—diluted	$ (5.55)	$ (0.29)	$ (7.13)	$ 0.51
Weighted average common shares outstanding used in computing net (loss) income per share—basic	47,511	47,184	47,491	46,840
Weighted average common shares outstanding used in computing net (loss) income per share—diluted	47,511	47,184	47,491	47,251
Net Product Revenues
Revenues:
Total net revenues	$ 44,800,000	$ 139,973,000	$ 133,325,000	$ 393,388,000
Royalty Revenues
Revenues:
Total net revenues	$ 2,922,000	$ 2,841,000	$ 8,586,000	$ 8,893,000

Consolidated Statements of Comprehensive (Loss) Income - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2019	Sep. 30, 2018	Sep. 30, 2019	Sep. 30, 2018
Statement Of Income And Comprehensive Income [Abstract]
Net (loss) income	$ (263,535)	$ (13,911)	$ (338,626)	$ 24,087
Other comprehensive (loss) income, net of tax:
Foreign currency translation adjustment	(3,190)	(721)	(3,671)	(2,703)
Unrealized (loss) income on available for sale debt securities	(63)	35	229	(42)
Other comprehensive loss, net of tax	(3,253)	(686)	(3,442)	(2,745)
Comprehensive (loss) income	$ (266,788)	$ (14,597)	$ (342,068)	$ 21,342

- Definition

The portion of profit or loss for the period, net of income taxes, which is attributable to the parent.

+ References + Details

Consolidated Statements of Changes in Stockholders' Equity - USD ($) $ in Thousands	Total	Common stock	Treasury stock	Additional paid-in capital	Accumulated deficit	Accumulated other comprehensive income
Balance at Dec. 31, 2017	$ 519,987	$ 46	$ (389)	$ 968,580	$ (455,108)	$ 6,858
Balance (in shares) at Dec. 31, 2017		46,441,000
Increase (Decrease) in Stockholders' Equity
Adjustment to accumulated deficit (pursuant to adoption of ASU 2014-09)	27,582				27,582
Compensation expense for issuance of stock options to employees	4,095			4,095
Compensation expense for issuance of restricted stock to employees	1,840			1,840
Compensation expense for issuance of restricted stock to employees (in shares)		100,000
Exercise of stock options	3,367	$ 1		3,366
Exercise of stock options (in shares)		137,000
Purchase of Treasury Stock	(1,202)		(1,202)
Purchase of Treasury Stock ,Shares		47,000
Other comprehensive (loss) income, net of tax	2,455					2,455
Net (loss) income	(8,199)				(8,199)
Balance at Mar. 31, 2018	549,925	$ 47	(1,591)	977,881	(435,725)	9,313
Balance (in shares) at Mar. 31, 2018		46,725,000
Balance at Dec. 31, 2017	519,987	$ 46	(389)	968,580	(455,108)	6,858
Balance (in shares) at Dec. 31, 2017		46,441,000
Increase (Decrease) in Stockholders' Equity
Net (loss) income	24,087
Balance at Sep. 30, 2018	598,625	$ 47	(1,976)	999,880	(403,439)	4,113
Balance (in shares) at Sep. 30, 2018		47,310,000
Balance at Mar. 31, 2018	549,925	$ 47	(1,591)	977,881	(435,725)	9,313
Balance (in shares) at Mar. 31, 2018		46,725,000
Increase (Decrease) in Stockholders' Equity
Compensation expense for issuance of stock options to employees	3,797			3,797
Compensation expense for issuance of restricted stock to employees	1,457			1,457
Compensation expense for issuance of restricted stock to employees (in shares)		16,000
Exercise of stock options	10,157			10,157
Exercise of stock options (in shares)		458,000
Purchase of Treasury Stock	(385)		(385)
Purchase of Treasury Stock ,Shares		24,000
Other comprehensive (loss) income, net of tax	(4,514)					(4,514)
Net (loss) income	46,197				46,197
Balance at Jun. 30, 2018	606,634	$ 47	(1,976)	993,292	(389,528)	4,799
Balance (in shares) at Jun. 30, 2018		47,223,000
Increase (Decrease) in Stockholders' Equity
Compensation expense for issuance of stock options to employees	3,866			3,866
Compensation expense for issuance of restricted stock to employees	1,269			1,269
Compensation expense for issuance of restricted stock to employees (in shares)		5,000
Exercise of stock options	1,454			1,454
Exercise of stock options (in shares)		82,000
Other comprehensive (loss) income, net of tax	(686)					(686)
Net (loss) income	(13,911)				(13,911)
Balance at Sep. 30, 2018	598,625	$ 47	(1,976)	999,880	(403,439)	4,113
Balance (in shares) at Sep. 30, 2018		47,310,000
Balance at Dec. 31, 2018	611,983	$ 48	(2,133)	1,005,105	(393,843)	2,806
Balance (in shares) at Dec. 31, 2018		47,508,000
Increase (Decrease) in Stockholders' Equity
Compensation expense for issuance of stock options to employees	2,745			2,745
Compensation expense for issuance of restricted stock to employees	922			922
Compensation expense for issuance of restricted stock to employees (in shares)		49,000
Exercise of stock options	24			24
Exercise of stock options (in shares)		2,000
Purchase of Treasury Stock	(52)		(52)
Purchase of Treasury Stock ,Shares		4,000
Other comprehensive (loss) income, net of tax	(1,431)					(1,431)
Net (loss) income	(47,605)				(47,605)
Balance at Mar. 31, 2019	566,586	$ 48	(2,185)	1,008,796	(441,448)	1,375
Balance (in shares) at Mar. 31, 2019		47,563,000
Balance at Dec. 31, 2018	$ 611,983	$ 48	(2,133)	1,005,105	(393,843)	2,806
Balance (in shares) at Dec. 31, 2018		47,508,000
Increase (Decrease) in Stockholders' Equity
Exercise of stock options (in shares)	2,000
Purchase of Treasury Stock	$ (91)
Purchase of Treasury Stock ,Shares	(7,360)
Net (loss) income	$ (338,626)
Balance at Sep. 30, 2019	281,342	$ 48	(638)	1,015,037	(732,469)	(636)
Balance (in shares) at Sep. 30, 2019		47,540,000
Balance at Mar. 31, 2019	566,586	$ 48	(2,185)	1,008,796	(441,448)	1,375
Balance (in shares) at Mar. 31, 2019		47,563,000
Increase (Decrease) in Stockholders' Equity
Compensation expense for issuance of stock options to employees	3,180			3,180
Compensation expense for issuance of restricted stock to employees	1,354			1,354
Compensation expense for issuance of restricted stock to employees (in shares)		34,000
Adjustments to Treasury Stock			1,586	(1,586)
Adjustments to Treasury Stock, Shares		(65,000)
Purchase of Treasury Stock	(39)		(39)
Purchase of Treasury Stock ,Shares		3,000
Other comprehensive (loss) income, net of tax	1,242					1,242
Net (loss) income	(27,486)				(27,486)
Balance at Jun. 30, 2019	544,837	$ 48	(638)	1,011,744	(468,934)	2,617
Balance (in shares) at Jun. 30, 2019		47,535,000
Increase (Decrease) in Stockholders' Equity
Compensation expense for issuance of stock options to employees	2,057			2,057
Compensation expense for issuance of restricted stock to employees	$ 1,236			1,236
Compensation expense for issuance of restricted stock to employees (in shares)		5,000
Purchase of Treasury Stock ,Shares	0
Other comprehensive (loss) income, net of tax	$ (3,253)					(3,253)
Net (loss) income	(263,535)				(263,535)
Balance at Sep. 30, 2019	$ 281,342	$ 48	$ (638)	$ 1,015,037	$ (732,469)	$ (636)
Balance (in shares) at Sep. 30, 2019		47,540,000

Consolidated Statements of Cash Flows - USD ($)	3 Months Ended	9 Months Ended		12 Months Ended
Consolidated Statements of Cash Flows - USD ($)	Sep. 30, 2019	Sep. 30, 2019	Sep. 30, 2018	Dec. 31, 2018
Cash flows from operating activities:
Net (loss) income		$ (338,626,000)	$ 24,087,000
Adjustments to reconcile (net loss) income to net cash (used in) provided by operating activities:
Share-based compensation expense		11,494,000	16,246,000
Amortization of net premiums and discounts on investments		(1,325,000)	(807,000)
Amortization of debt discount and debt issuance costs		12,202,000	11,917,000
Depreciation and amortization expense		24,697,000	9,118,000
Goodwill impairment	$ 277,561,000	277,561,000
Change in acquired contingent consideration obligation		(56,342,000)	21,900,000
Non-cash royalty revenue		(7,556,000)	(7,826,000)
Deferred tax (benefit) provision		(3,667,000)	42,565,000
Changes in assets and liabilities:
Decrease in accounts receivable		5,877,000	29,942,000
Decrease (increase) in prepaid expenses and other current assets		13,725,000	(5,319,000)
Decrease in inventory		1,619,000	26,701,000
Decrease in other assets			25,000
Decrease in accounts payable, accrued expenses and other current liabilities		(56,141,000)	(5,508,000)
(Decrease) increase in other non-current liabilities		(256,000)	90,000
Net cash (used in) provided by operating activities		(116,738,000)	163,131,000
Cash flows from investing activities:
Purchases of property and equipment		(76,414,000)	(22,548,000)
Purchases of intangible assets			(375,000)
Purchases of investments		(171,431,000)	(191,652,000)
Proceeds from maturities of investments		191,342,000	52,539,000
Net cash used in investing activities		(56,503,000)	(162,036,000)
Cash flows from financing activities:
Proceeds from issuance of common stock and option exercises		24,000	14,978,000
Purchase of treasury stock		(91,000)	(1,587,000)
Repayment of loans payable		(614,000)	(656,000)
Net cash (used in) provided by financing activities		(681,000)	12,735,000
Effect of exchange rate changes on cash, cash equivalents and restricted cash		(265,000)	(238,000)
Net (decrease) increase in cash, cash equivalents and restricted cash		(174,187,000)	13,592,000
Cash, cash equivalents and restricted cash at beginning of period		294,351,000	308,039,000	$ 308,039,000
Cash, cash equivalents and restricted cash at end of period	$ 120,164,000	120,164,000	321,631,000	$ 294,351,000
Supplemental disclosure:
Cash paid for interest		3,037,000	3,045,000
Cash paid for taxes		$ 2,562,000	$ 16,665,000

Organization and Business Activities

9 Months Ended

Sep. 30, 2019

Organization Consolidation And Presentation Of Financial Statements [Abstract]

Organization and Business Activities

(1) Organization and Business Activities

Acorda Therapeutics, Inc. (“Acorda” or the “Company”) is a biopharmaceutical company focused on developing therapies that restore function and improve the lives of people with neurological disorders.

The accompanying unaudited consolidated financial statements have been prepared in accordance with accounting principles generally accepted in the United States (GAAP) for interim financial information, Accounting Standards Codification (ASC) Topic 270-10 and with the instructions to Form 10-Q. Accordingly, these financial statements do not include all of the information and footnotes required by GAAP for complete financial statements. In management’s opinion, all adjustments considered necessary for a fair presentation have been included in the interim periods presented and all adjustments are of a normal recurring nature. The Company has evaluated subsequent events through the date of this filing. Operating results for the three and nine-month periods ended September 30, 2019 are not necessarily indicative of the results that may be expected for the year ending December 31, 2019. When used in these notes, the terms “Acorda” or “the Company” mean Acorda Therapeutics, Inc. The December 31, 2018 consolidated balance sheet data was derived from audited financial statements, but does not include all disclosures required by GAAP. You should read these unaudited interim condensed consolidated financial statements in conjunction with the consolidated financial statements and footnotes included in the Company's Annual Report on Form 10-K, for the year ended December 31, 2018.

Certain reclassifications were made to prior period amounts in the consolidated financial statements to conform to the current year presentation.

Summary of Significant Accounting Policies

9 Months Ended

Sep. 30, 2019

Accounting Policies [Abstract]

Summary of Significant Accounting Policies

(2) Summary of Significant Accounting Policies

Our significant accounting policies are detailed in our Annual Report on Form 10-K for the year ended December 31, 2018. Effective January 1, 2019, the Company adopted ASU 2016-02, “Leases” (Topic 842), ASU 2018-05, “Income Taxes” (Topic 740), ASU 2018-09, “Codification Improvements” and ASU 2018-02, “Income Statement—Reporting Comprehensive Income” (Topic 220). Effective April 1, 2019, the Company adopted ASU 2017-04, “Intangibles – Goodwill and Other” (Topic 350). Other than the adoption of the new accounting guidance, our significant accounting policies have not changed materially from December 31, 2018.

Restricted Cash

The following table provides a reconciliation of cash, cash equivalents, and restricted cash reported within the statement of financial position that sum to the total of the same amounts shown in the statement of cash flows:

	Nine-month period ended September 30, 2019				Nine-month period ended September 30, 2018
(In thousands)	Beginning of period		End of period		Beginning of period		End of period
Cash and cash equivalents	$	293,564	$	119,521	$	307,068	$	321,011
Restricted cash		532		387		410		365
Restricted cash included in Other assets		255		256		561		255
Total Cash, cash equivalents and restricted cash per statement of cash flows	$	294,351	$	120,164	$	308,039	$	321,631

Amounts included in restricted cash represent those amounts required to be set aside to cover the Company’s self-funded employee health insurance. Restricted cash included in other assets on the statement of financial position relates to cash collateralized standby letters of credit in connection with obligations under facility leases, which is included with other assets in the consolidated balance sheet due to the long-term nature of the letters of credit.

Inventory

The major classes of inventory were as follows:

(In thousands)	September 30, 2019		December 31, 2018
Raw materials	$	996	$	—
Work-in-progress		15,561		—
Finished goods		10,839		29,014
Total	$	27,396	$	29,014

The Company reviews inventory, including inventory purchase commitments, for slow moving or obsolete amounts based on expected product sales volume and provides reserves against the carrying amount of inventory as appropriate.

Foreign Currency Translation

The functional currency of operations outside the United States of America is deemed to be the currency of the local country, unless otherwise determined that the United States dollar would serve as a more appropriate functional currency given the economic operations of the entity. Accordingly, the assets and liabilities of the Company’s foreign subsidiary, Biotie, are translated into United States dollars using the period-end exchange rate; income and expense items are translated using the average exchange rate during the period; and equity transactions are translated at historical rates. Cumulative translation adjustments are reflected as a separate component of equity. Foreign currency transaction losses and gains are recognized in the period incurred and are reported as other (expense) income, net in the statement of operations.

Segment and Geographic Information

The Company is managed and operated as one business which is focused on developing therapies that restore function and improve the lives of people with neurological disorders. The entire business is managed by a single management team that reports to the Chief Executive Officer. The Company does not operate separate lines of business with respect to any of its products or product candidates and the Company does not prepare discrete financial information with respect to separate products or product candidates or by location. Accordingly, the Company views its business as one reportable operating segment. Net product revenues reported are derived from the sales of Inbrija in the U.S. for the three and nine-month periods ended September 30, 2019 and from the sales of Ampyra in the U.S. for the three and nine-month periods ended September 30, 2019 and 2018.

Goodwill

Goodwill represents the amount of consideration paid in excess of the fair value of net assets acquired in a business combination accounted for using the acquisition method of accounting. Goodwill is not amortized and is subject to impairment testing on an annual basis or when a triggering event occurs that may indicate the carrying value of the goodwill is impaired. We perform our impairment testing at the reporting level where we have determined that we have a single reporting unit and operating segment. The impairment test for goodwill uses an approach which compares the estimated fair value of the reporting unit including goodwill to its carrying value. If the carrying value of the reporting unit exceeds the estimated fair value of the reporting unit, an impairment loss is recognized in an amount equal to the excess of the carrying value over the estimated fair value.

During the second quarter of 2019, we experienced a significant decline in our stock price that reduced the market capitalization below the carrying value of the Company. This circumstance required the Company to perform a quantitative assessment to assess the value of the goodwill for impairment. The Company performed an assessment of the goodwill and concluded that there was no impairment. During the third quarter of 2019, we experienced a further significant decline in our stock price that reduced the market capitalization below the carrying value of the Company. The Company performed a quantitative assessment of the goodwill and concluded that there was an impairment to the goodwill. The Company utilized the income approach in the goodwill assessment process. The determination of the fair value of the reporting unit requires us to make significant estimates and assumptions. This valuation approach considers a number of factors that include, but are not limited to, prospective financial information, growth rates, terminal value, and discount rates and require us to make certain assumptions and estimates. When performing our income approach, we incorporate the use of projected financial

information and a discount rate that are developed based on certain assumptions. Due to the inherent uncertainty involved in making these estimates, actual results could differ from those estimates. The Company then corroborates the reasonableness of the total fair value of the reporting unit by reconciling the aggregate fair value of the reporting unit to the Company’s total market capitalization adjusted to include an estimated control premium. The estimated control premium is derived from reviewing observable transactions involving the purchase of controlling interests in comparable companies. The market capitalization is calculated using the relevant shares outstanding and the closing stock price at the test date. After completing our impairment assessment during the third quarter of 2019, we concluded that the carrying value of the Company exceeded its estimated fair value as of September 30, 2019 and therefore, the goodwill was fully impaired. The Company recorded an impairment charge of $277.6 million for the three and nine-month periods ended September 30, 2019 in the statement of operations.

Impairment of Long-Lived Assets

The Company continually evaluates whether events or circumstances have occurred that indicate that the estimated remaining useful lives of its long-lived assets, including identifiable intangible assets subject to amortization and property plant and equipment, may warrant revision or that the carrying value of the assets may be impaired. Factors the Company considers important that could trigger an impairment review include significant changes in the use of any assets, changes in historical trends in operating performance, changes in projected operating performance, stock price, loss of a major customer and significant negative economic trends. The decline in the trading price of the Company's common stock during the quarter ended September 30, 2019, and related decrease in the Company's market capitalization, was determined to be a triggering event in connection with the Company's review of the recoverability of its long-lived assets for the three-month period ended September 30, 2019. The Company performed a recoverability test during the third quarter of fiscal 2019 using the undiscounted cash flows, which are the sum of the future undiscounted cash flows expected to be derived from the direct use of the long-lived assets to the carrying value of the long-lived assets. Estimates of future cash flows were based on the Company’s own assumptions about its own use of the long-lived assets. The cash flow estimation period was based on the long-lived assets’ estimated remaining useful life to the Company. After performing the recoverability test, the Company determined that the undiscounted cash flows exceeded the carrying value and the long-lived assets were not impaired. Changes in these assumptions and resulting valuations or further declines in our stock price could result in future long-lived asset impairment charges. Management will continue to monitor any changes in circumstances for indicators of impairment. Any write‑downs are treated as permanent reductions in the carrying amount of the assets.

Subsequent Events

Subsequent events are defined as those events or transactions that occur after the balance sheet date, but before the financial statements are filed with the Securities and Exchange Commission. The Company completed an evaluation of the impact of any subsequent events through the date these financial statements were issued, and determined the following subsequent event that required disclosure in these financial statements.

On October 23, 2019, we announced a corporate restructuring to reduce costs and focus our resources on the commercial launch of Inbrija, which is our key strategic priority for the remainder of 2019. As part of the restructuring, we are reducing headcount by approximately 25% through a reduction in force. The majority of the reduction took place in the fourth quarter of 2019 immediately after the announcement, and the remainder will be completed by the first quarter of 2020.

Accounting Pronouncements Adopted

In February 2016, the FASB issued ASU 2016-02, “Leases” Topic 842, which amends the guidance in former ASC Topic 840, Leases. The new standard increases transparency and comparability most significantly by requiring the recognition by lessees of right-of-use (“ROU”) assets and lease liabilities on the balance sheet for all leases longer than 12 months. Under the standard, disclosures are required to meet the objective of enabling users of financial statements to assess the amount, timing, and uncertainty of cash flows arising from leases. For lessees, leases will be classified as finance or operating, with classification affecting the pattern and classification of expense recognition in the income statement.

The Company adopted the new lease guidance effective January 1, 2019 using the modified retrospective transition approach, applying the new standard to all of its leases existing at the date of initial application which is the effective date of adoption. Consequently, financial information will not be updated and the disclosures required under the new standard will not be provided for dates and periods before January 1, 2019. We elected the package of practical expedients which permits us to not reassess (1) whether any expired or existing contracts are or contain leases, (2) the lease classification for any

expired or existing leases, and (3) any initial direct costs for any existing leases as of the effective date. We did not elect the hindsight practical expedient which permits entities to use hindsight in determining the lease term and assessing impairment. The adoption of the lease standard did not change our previously reported consolidated statements of operations and did not result in a cumulative catch-up adjustment to opening equity. See Note 12 for further information.

In August 2018, the Securities Exchange Commission (“SEC”) adopted the final rule under SEC Release No. 33-10532, Disclosure Update and Simplification, amending certain disclosure requirements that were redundant, duplicative, overlapping, outdated or superseded. In addition, the amendments expanded the disclosure requirements on the analysis of stockholders’ equity for interim financial statements. Under the amendments, an analysis of changes in each caption of stockholders’ equity presented in the balance sheet must be provided in a note or separate statement. The analysis should present a reconciliation of the beginning balance to the ending balance of each period for which a statement of comprehensive income is required to be filed. The Company adopted the rule in the three-month period ended March 31, 2019 and included its first presentation of changes in stockholders’ equity in its Form 10-Q for the three-month period ended March 31, 2019.

In February 2018, the FASB issued ASU 2018-02, “Income Statement—Reporting Comprehensive Income” (Topic 220): Reclassification of Certain Tax Effects from Accumulated Other Comprehensive Income (ASU 2018-02). This new standard provides entities with an option to reclassify stranded tax effects within AOCI to retained earnings in each period in which the effect of the change in the U.S. federal corporate income tax rate in the Tax Cuts and Jobs Act (or portion thereof) is recorded. The reclassification is the difference between the amount previously recorded in other comprehensive income at the historical U.S. federal tax rate that remains in accumulated other comprehensive loss at the time the Act was effective and the amount that would have been recorded using the newly enacted rate. This guidance became effective in Q1 2019; however, the Company did not elect to make the optional reclassification.

In July 2018, the FASB issued ASU 2018-09, “Codification Improvements.” The ASU’s amendments clarify, correct errors in, or make minor improvements to a variety of ASC topics. The changes in ASU 2018-09 are not expected to have a significant effect on current accounting practices. Some of the amendments in this update do not require transition guidance and will be effective upon issuance of this update. However, many of the amendments in this update do have transition guidance with effective dates for annual periods beginning after December 15, 2018, for public business entities. The ASU became effective in Q1 2019. The ASU did not have a significant impact on its consolidated financial statements.

In January 2017, the FASB issued ASU 2017-04, “Intangibles – Goodwill and Other” (Topic 350): Simplifying the Test for Goodwill Impairment (ASU 2017-04). This new standard simplifies how an entity is required to test goodwill for impairment by eliminating Step 2 from the goodwill impairment test. ASU 2017-04 allows for prospective application and is effective for fiscal years beginning after December 15, 2019, and interim periods therein with early adoption permitted for interim or annual goodwill impairment tests performed on testing dates after January 1, 2017. The Company adopted this guidance on April 1, 2019. The ASU did not have an impact upon adoption on its consolidated financial statements.

Accounting Pronouncements Not Yet Adopted

In June 2016, the FASB issued ASU 2016-13, “Financial Instruments – Credit Losses” (Topic 326): Measurement of Credit Losses on Financial Instruments and subsequently amended by ASU 2019-04 and ASU 2019-05 which introduces a forward-looking approach, based on expected losses, to estimate credit losses on certain types of financial instruments, including trade receivables. This new standard amends the current guidance on the impairment of financial instruments. The ASU adds to U.S. GAAP an impairment model known as current expected credit loss (CECL) model that is based on expected losses rather than incurred losses. Under the new guidance, an entity will recognize as an allowance its estimate of expected credit losses. The ASU is effective for fiscal years beginning after December 15, 2019, and interim periods within those fiscal years with early adoption permitted. The Company is currently evaluating the impact the adoption of this guidance may have on its consolidated financial statements and will adopt the guidance when effective.

In August 2018, the FASB issued ASU 2018-13 “Fair Value Measurement (Topic 820): “Disclosure Framework—Changes to the Disclosure Requirements for Fair Value Measurement.” The amendment in this ASU eliminate, add and modify certain disclosure requirements for fair value measurements as part of its disclosure framework project. Entities will no longer be required to disclose the amount of and reasons for transfers between Level 1 and Level 2 of the fair value hierarchy, but public business entities will be required to disclose the range and weighted average used to develop significant unobservable inputs for Level 3 fair value measurements. The ASU is effective for all entities for fiscal years beginning after December 15, 2019, and interim periods within those fiscal years with early adoption permitted. The Company is currently evaluating the impact the adoption of this guidance may have on its consolidated financial statements.

In August 2018, the FASB issued ASU 2018-15, “Customer’s Accounting for Implementation Costs Incurred in a Cloud Computing Arrangement That Is a Service Contract.” The ASU clarifies certain aspects of ASU 2015-05, “Customer’s Accounting for Fees Paid in a Cloud Computing Arrangement,” which was issued in April 2015. Specifically, the ASU 2018-15 aligns the requirements for capitalizing implementation costs incurred in a hosting arrangement that is a service contract with the requirements for capitalizing implementation costs incurred to develop or obtain internal-use software (and hosting arrangements that include an internal-use software license).” The ASU is effective for fiscal years beginning after December 15, 2019, and interim periods within those fiscal years with early adoption permitted. The Company is currently evaluating the impact the adoption of this guidance may have on its consolidated financial statements.

In November 2018, the FASB issued ASU 2018-18, Collaborative arrangements (Topic 808): Clarifying the Interaction Between Topic 808 and Topic 606. ASU 2018-18 clarifies that certain transactions between participants in a collaborative arrangement should be accounted for under ASC 606 when the counterparty is a customer and precludes an entity from presenting consideration from a transaction in a collaborative arrangement as revenue from contracts with customers if the counterparty is not a customer for that transaction. The ASU is effective for fiscal years beginning after December 15, 2019, and interim periods within those fiscal years with early adoption permitted. The Company is currently evaluating the impact the adoption of this guidance may have on its consolidated financial statements.

Revenue

9 Months Ended

Sep. 30, 2019

Revenue From Contract With Customer [Abstract]

Revenue

(3) Revenue

In accordance with ASC 606, the Company recognizes revenue when the customer obtains control of a promised good or service, in an amount that reflects the consideration to which the Company expects to be entitled in exchange for the good or service. ASC 606 outlines a five-step process for recognizing revenue from contracts with customers: i) identify the contract with the customer, ii) identify the performance obligations in the contract, iii) determine the transaction price, iv) allocate the transaction price to the separate performance obligations in the contract, and v) recognize revenue associated with the performance obligations as they are satisfied. The Company only applies the five-step model to contracts when it is probable that the Company will collect the consideration it is entitled to in exchange for the goods or services it transfers to the customer. Once a contract is determined to be within the scope of ASC 606, the Company determines the performance obligations that are distinct. The Company recognizes as revenue the amount of the transaction price that is allocated to each respective performance obligation when the performance obligation is satisfied or as it is satisfied. Generally, the Company's performance obligations are transferred to customers at a point in time, typically upon receipt of the product by the customer.

ASC 606 requires entities to record a contract asset when a performance obligation has been satisfied or partially satisfied, but the amount of consideration has not yet been received because the receipt of the consideration is conditioned on something other than the passage of time. ASC 606 also requires an entity to present a revenue contract as a contract liability in instances when a customer pays consideration, or an entity has a right to an amount of consideration that is unconditional (e.g. receivable), before the entity transfers a good or service to the customer. We did not have any contract assets or any contract liabilities as of September 30, 2019 and 2018.

The following table disaggregates our revenue by major source:

(In thousands)	Three-month period ended September 30, 2019		Three-month period ended September 30, 2018		Nine-month period ended September 30, 2019		Nine-month period ended September 30, 2018
Revenues:
Net product revenues:
Ampyra	$	37,647	$	137,815	$	122,383	$	390,900
Inbrija		4,889		—		9,164		—
Other		2,264		2,158		1,778		2,488
Total net product revenues		44,800		139,973		133,325		393,388
Royalty revenues		2,922		2,841		8,586		8,893
Total net revenues	$	47,722	$	142,814	$	141,911	$	402,281

Share-based Compensation

9 Months Ended

Sep. 30, 2019

Disclosure Of Compensation Related Costs Sharebased Payments [Abstract]

Share-based Compensation

(4) Share-based Compensation

During the three‑month periods ended September 30, 2019 and 2018, the Company recognized share-based compensation expense of $3.3 million and $5.1 million, respectively. During the nine-month periods ended September 30,

2019 and 2018, the Company recognized share-based compensation expense of $11.5 and $16.2 million, respectively. Activity in options and restricted stock during the nine-month period ended September 30, 2019 and related balances outstanding as of that date are reflected below. The weighted average fair value per share of options granted to employees for the three-month periods ended September 30, 2019 and 2018 were approximately $2.69 and $12.39, respectively. The weighted average fair value per share of options granted to employees for the nine-month periods ended September 30, 2019 and 2018 were approximately $6.49 and $12.81, respectively.

The following table summarizes share-based compensation expense included within the consolidated statements of operations:

	For the three-month period ended September 30,				For the nine-month period ended September 30,
(In thousands)	2019		2018		2019		2018
Research and development expense	$	719	$	1,112	$	2,203	$	4,336
Selling, general and administrative expense		2,424		4,023		8,785		11,910
Cost of Sales		149		—		505		—
Total	$	3,292	$	5,135	$	11,493	$	16,246

A summary of share-based compensation activity for the nine-month period ended September 30, 2019 is presented below:

Stock Option Activity

	Number of Shares (In thousands)			Weighted Average Exercise Price		Weighted Average Remaining Contractual Term		Intrinsic Value (In thousands)
Balance at January 1, 2019		8,194		$	29.81
Granted		640			12.16
Cancelled		(494	)		24.83
Exercised		(2	)		16.00
Balance at September 30, 2019		8,339		$	28.76		4.8	$	—
Vested and expected to vest at September 30, 2019		8,316		$	28.79		4.8	$	—
Vested and exercisable at September 30, 2019		7,165		$	30.23		4.2	$	—

Restricted Stock and Performance Stock Unit Activity

(In thousands)
Restricted Stock and Performance Stock Units	Number of Shares
Nonvested at January 1, 2019		231
Granted		628
Vested		(96	)
Forfeited		(52	)
Nonvested at September 30, 2019		711

Unrecognized compensation cost for unvested stock options, restricted stock awards and performance stock units as of September 30, 2019 totaled $17.1 million and is expected to be recognized over a weighted average period of approximately 2.1 years.

During the three‑month period ended September 30, 2019, the Company did not make any repurchases of shares. During the nine‑month period ended September 30, 2019, the Company repurchased 7,360 shares of common stock at an average price of $12.31 per share or approximately $91 thousand. The share repurchase consists primarily of common stock tendered to cover tax liabilities in connection with the vesting of restricted stock awards and common stock withheld to cover

tax liabilities in connection with the settlement of vested restricted stock units in the nine-month period ended September 30, 2019.

(Loss) Income Per Share

9 Months Ended

Sep. 30, 2019

Earnings Per Share [Abstract]

(Loss) Income Per Share

(5) (Loss) Income Per Share

The following table sets forth the computation of basic and diluted (loss) income per share for the three and nine-month periods ended September 30, 2019 and 2018:

(In thousands, except per share data)	Three-month period ended September 30, 2019			Three-month period ended September 30, 2018			Nine-month period ended September 30, 2019			Nine-month period ended September 30, 2018
Basic and diluted
Net (loss) income	$	(263,535	)	$	(13,911	)	$	(338,626	)	$	24,087
Weighted average common shares outstanding used in computing net (loss) income per share—basic		47,511			47,184			47,491			46,840
Plus: net effect of dilutive stock options and restricted common shares		—			—			—			411
Weighted average common shares outstanding used in computing net (loss) income per share—diluted		47,511			47,184			47,491			47,251
Net (loss) income per share—basic	$	(5.55	)	$	(0.29	)	$	(7.13	)	$	0.51
Net (loss) income per share—diluted	$	(5.55	)	$	(0.29	)	$	(7.13	)	$	0.51

Securities that could potentially be dilutive are excluded from the computation of diluted loss per share when a loss from continuing operations exists or when the exercise price exceeds the average closing price of the Company’s common stock during the period, because their inclusion would result in an anti-dilutive effect on per share amounts.

The following amounts were not included in the calculation of net loss per diluted share because their effects were anti-dilutive:

(In thousands)

Three-month period ended September 30, 2019

Three-month period ended September 30, 2018

Nine-month period ended September 30, 2019

Nine-month period ended September 30, 2018

Denominator

Stock options and restricted common shares

8,995

8,825

8,995

7,262

Performance share units are excluded from the calculation of net loss per diluted share as the performance criteria has not been met for the three and nine-month periods ended September 30, 2019. Additionally, the impact of the convertible senior notes was determined to be anti-dilutive and excluded from the calculation of net loss per diluted share for the three and nine-month periods ended September 30, 2019 and 2018.

Income Taxes

9 Months Ended

Sep. 30, 2019

Income Tax Disclosure [Abstract]

Income Taxes

(6) Income Taxes

The Company’s effective income tax rate differs from the U.S. statutory rate principally due to state taxes, jurisdictions with pretax losses for which no tax benefit can be recognized, changes in the valuation allowance and the effects of share based compensation which are recorded discretely in the quarters in which they occur.

For the three-month periods ended September 30, 2019 and 2018, the Company recorded a provision of $0.02 million and $38.0 million for income taxes, respectively. The effective income tax rates for the Company for the three-month periods ended September 30, 2019 and 2018 were 0% and 157.8%, respectively. The variance in the effective tax rates for the three-month period ended September 30, 2019 as compared to the three-month period ended September 30, 2018 was due primarily to differences in pre-tax book loss between the periods, goodwill impairment for which no tax benefit is recognized, the valuation allowance recorded on deferred tax assets for which no tax benefit can be recognized, state taxes, and the reduction in the research & development tax credit.

For the nine-month periods ended September 30, 2019 and 2018, the Company recorded a benefit of $0.5 million and a provision of $49.8 million for income taxes, respectively. The effective income tax rates for the Company for the nine-month

periods ended September 30, 2019 and 2018 were 0.14% and 67.4%, respectively. The variance in the effective tax rates for the nine-month period ended September 30, 2019 as compared to the nine-month period ended September 30, 2018 was due primarily to differences in pre-tax book (loss) income between the periods, goodwill impairment for which no tax benefit is recognized, the valuation allowance recorded on deferred tax assets for which no tax benefit can be recognized, state taxes, and the reduction in the research & development tax credit.

The Company continues to evaluate the realizability of its deferred tax assets on a quarterly basis and will adjust such amounts in light of changing facts and circumstances including, but not limited to, future projections of taxable income, tax legislation, rulings by relevant tax authorities, the progress of ongoing tax audits and the regulatory approval of products currently under development. Any changes to the valuation allowance or deferred tax assets and liabilities in the future would impact the Company's income taxes.

The Internal Revenue Service commenced its examination of the Company’s wholly-owned subsidiary, Biotie Therapies, Inc.’s, U.S. income tax return for the short period ended December 31, 2016 in the third quarter of 2018. The audit has been substantially completed, and the IRS has proposed an adjustment that we do not believe would have a material impact on the tax provision.

The New York State Department of Tax commenced an examination of the Company’s income tax returns for the years 2014-2016 in the third quarter of 2018. There have been no proposed adjustments at this stage of the examination.

Goodwill

9 Months Ended

Sep. 30, 2019

Goodwill [Abstract]

Goodwill

(7) Goodwill

The following table represents a summary of activities in goodwill from December 31, 2018 through September 30, 2019:

(In thousands)
Balance at December 31, 2018	$	282,059
Impairment		(277,561	)
Foreign currency translation adjustment		(4,498	)
Balance at September 30, 2019	$	—

At September 30, 2019 and December 31, 2018, the Company had $0.0 million and $282.1 million of goodwill, respectively. In connection with the Company's review of the recoverability of its goodwill for the three month period ended September 30, 2019, the Company determined that a triggering event occurred due to the decline in the trading price of the Company's common stock at and around the end of the third quarter of 2019 and related decrease in the Company's market capitalization. Given this circumstance, the Company performed a quantitative goodwill impairment test. Based on the results of its impairment test, the Company recorded an impairment charge of $277.6 million which was the carrying amount of its goodwill immediately before the charge. Refer to Note 2 for the discussion of the impairment charge.

Fair Value Measurements

9 Months Ended

Sep. 30, 2019

Fair Value Disclosures [Abstract]

Fair Value Measurements

(8) Fair Value Measurements

The following table presents information about the Company’s assets and liabilities measured at fair value on a recurring basis as of September 30, 2019 and December 31, 2018 and indicates the fair value hierarchy of the valuation techniques utilized to determine such fair value. In general, fair values determined by Level 1 inputs utilize quoted prices (unadjusted) in active markets for identical assets or liabilities. Fair values determined by Level 2 inputs utilize data points that are observable, such as quoted prices, interest rates, exchange rates and yield curves. Fair values determined by Level 3 inputs utilize unobservable data points for the asset or liability. The Company’s Level 1 assets consist of investments in a Treasury money market fund and U.S. government securities. The Company’s level 2 assets consist of investments in corporate bonds, commercial paper and U.S. government securities which are categorized as short-term investments for investments with original maturities between three months and one year. The Company’s Level 3 liabilities represent acquired contingent consideration related to the acquisition of Civitas and are valued using a probability weighted discounted cash flow valuation approach. No changes in valuation techniques occurred during the three or nine-month periods ended September 30, 2019. The estimated fair values of all of our financial instruments approximate their carrying values at September 30, 2019, except for the fair value of the Company’s convertible senior notes, which was approximately $264.3 million as of September 30, 2019. The Company estimates the fair value of its notes utilizing market quotations for the debt (Level 2).

(In thousands)	Level 1		Level 2		Level 3
September 30, 2019
Assets Carried at Fair Value:
Money market funds	$	28,899	$	—	$	—
U.S. government securities		2,500		13,246		—
Commercial paper		—		49,054		—
Corporate bonds		—		71,336		—
Liabilities Carried at Fair Value:
Acquired contingent consideration		—		—		111,200
December 31, 2018
Assets Carried at Fair Value:
Money market funds	$	9,586	$	—	$	—
Commercial paper		—		47,108		—
Corporate bonds		—		104,881		—
Liabilities Carried at Fair Value:
Acquired contingent consideration		—		—		168,000

The following table presents additional information about liabilities measured at fair value on a recurring basis and for which the Company utilizes Level 3 inputs to determine fair value.

Acquired contingent consideration

(In thousands)	Three-month period ended September 30, 2019			Three-month period ended September 30, 2018		Nine-month period ended September 30, 2019			Nine-month period ended September 30, 2018
Acquired contingent consideration:
Balance, beginning of period	$	162,537		$	112,200	$	168,000		$	113,000
Fair value change to contingent consideration included in the statement of operations		(50,942	)		22,700		(56,342	)		21,900
Royalty payments		(395	)		—		(458	)		—
Balance, end of period	$	111,200		$	134,900	$	111,200		$	134,900

The Company estimates the fair value of its acquired contingent consideration using a probability weighted discounted cash flow valuation approach based on estimated future sales expected from Inbrija (levodopa inhalation powder), an FDA approved drug for the treatment of OFF periods in Parkinson’s disease. Using this approach, expected probability adjusted future cash flows are calculated over the expected life of the agreement and discounted to estimate the current value of the

liability at the period end date. Some of the more significant assumptions made in the valuation include (i) the estimated revenue forecasts for Inbrija, (ii) probabilities of success, and (iii) discount periods and rate. Milestone payments ranged from $1.0 million to $59.0 million for Inbrija. The valuation is performed quarterly and changes in the fair value of the contingent consideration are included in the statement of operations. For the three and nine-month periods ended September 30, 2019 and 2018, changes in the fair value of the acquired contingent consideration were primarily due to the re-calculation of cash flows for the passage of time and updates to certain other estimated assumptions. The Company has deferred consideration of further investment in the ARCUS program for acute treatment of migraine pending additional progress with the Inbrija launch.

The acquired contingent consideration is classified as a Level 3 liability as its valuation requires substantial judgment and estimation of factors that are not currently observable in the market. If different assumptions were used for the various inputs to the valuation approach, including but not limited to, assumptions involving probability adjusted sales estimates for Inbrija and the estimated discount rates, the estimated fair value could be significantly higher or lower than the fair value determined.

- Definition

The entire disclosure for the fair value of financial instruments (as defined), including financial assets and financial liabilities (collectively, as defined), and the measurements of those instruments as well as disclosures related to the fair value of non-financial assets and liabilities. Such disclosures about the financial instruments, assets, and liabilities would include: (1) the fair value of the required items together with their carrying amounts (as appropriate); (2) for items for which it is not practicable to estimate fair value, disclosure would include: (a) information pertinent to estimating fair value (including, carrying amount, effective interest rate, and maturity, and (b) the reasons why it is not practicable to estimate fair value; (3) significant concentrations of credit risk including: (a) information about the activity, region, or economic characteristics identifying a concentration, (b) the maximum amount of loss the entity is exposed to based on the gross fair value of the related item, (c) policy for requiring collateral or other security and information as to accessing such collateral or security, and (d) the nature and brief description of such collateral or security; (4) quantitative information about market risks and how such risks are managed; (5) for items measured on both a recurring and nonrecurring basis information regarding the inputs used to develop the fair value measurement; and (6) for items presented in the financial statement for which fair value measurement is elected: (a) information necessary to understand the reasons for the election, (b) discussion of the effect of fair value changes on earnings, (c) a description of [similar groups] items for which the election is made and the relation thereof to the balance sheet, the aggregate carrying value of items included in the balance sheet that are not eligible for the election; (7) all other required (as defined) and desired information.

+ References + Details

Investments

9 Months Ended

Sep. 30, 2019

Investments Debt And Equity Securities [Abstract]

Investments

(9) Investments

The Company has determined that all of its investments are classified as available-for-sale. Available-for-sale debt securities are carried at fair value with interest on these investments included in interest income and are recorded based on quoted market prices. Available-for-sale investments consisted of the following at September 30, 2019 and December 31, 2018, respectively:

			Gross		Gross			Estimated
	Amortized		Unrealized		Unrealized			Fair
(In thousands)	Cost		Gains		Losses			Value
September 30, 2019
Commercial Paper	$	49,041	$	24	$	(11	)	$	49,054
Corporate Bonds		71,241		104		(9	)		71,336
U.S. government securities		13,250		—		(4	)		13,246
Total Short-term investments	$	133,532	$	128	$	(24	)	$	133,636
December 31, 2018
Commercial Paper	$	47,149	$	—	$	(41	)	$	47,108
Corporate Bonds		104,965		6		(90	)		104,881
Total Short-term investments	$	152,114	$	6	$	(131	)	$	151,989

Short-term investments with maturities of three months or less from date of purchase have been classified as cash equivalents, and amounted to approximately $31.4 million and $9.6 million as of September 30, 2019 and December 31, 2018, respectively. Short-term investments have original maturities of greater than 3 months but less than 1 year and amounted to approximately $133.6 million and $152.0 million as of September 30, 2019 and December 31, 2018, respectively. The aggregate fair value of short-term investments in an unrealized loss position amounted to approximately $48.7 million as of September 30, 2019. Short-term investments at September 30, 2019 primarily consisted of high-grade commercial paper, corporate bonds and U.S. government securities. Long-term investments have original maturities of greater than 1 year. There were no investments classified as long-term at September 30, 2019 or December 31, 2018. The Company has determined that there were no other-than-temporary declines in the fair values of its investments as of September 30, 2019 as the Company does not intend to sell its investments and it is not more likely than not that the Company will be required to sell its investments prior to the recovery of its amortized cost basis.

Unrealized holding gains and losses, which relate to debt instruments, are reported within accumulated other comprehensive income (AOCI) in the statements of comprehensive income. The changes in AOCI associated with the unrealized holding gains on available-for-sale investments during the nine-month period ended September 30, 2019, were as follows (in thousands):

(In thousands)	Net Unrealized Gains (Losses) on Marketable Securities
Balance at December 31, 2018	$	(125	)
Other comprehensive income before reclassifications		229
Amounts reclassified from accumulated other comprehensive income		—
Net current period other comprehensive income		229
Balance at September 30, 2019	$	104

Liability Related to Sale of Future Royalties

9 Months Ended

Sep. 30, 2019

Deferred Revenue Disclosure [Abstract]

(10) Liability Related to Sale of Future Royalties

As of October 1, 2017, the Company completed a royalty purchase agreement with HealthCare Royalty Partners, or HCRP (“Royalty Agreement”). In exchange for the payment of $40 million to the Company, HCRP obtained the right to receive Fampyra royalties payable by Biogen under the License and Collaboration Agreement between the Company and Biogen, up to an agreed upon threshold of royalties. When this threshold is met, if ever, the Fampyra royalties will revert back to the Company and the Company will continue to receive the Fampyra royalties from Biogen until the revenue stream ends. The transaction does not include potential future milestones to be paid.

The Company maintained the rights under the license and collaboration agreement with Biogen, therefore, the Royalty Agreement has been accounted for as a liability that will be amortized using the effective interest method over the life of the arrangement, in accordance with the relevant accounting guidance. The Company recorded the receipt of the $40 million payment from HCRP and established a corresponding liability in the amount of $40 million, net of transaction costs of approximately $2.2 million. The net liability is classified between the current and non-current portion of liability related to the sale of future royalties in the consolidated balance sheets based on the recognition of the interest and principal payments to be received by HCRP in the next 12 months from the financial statement reporting date. The total net royalties to be paid, less the net proceeds received will be recorded to interest expense using the effective interest method over the life of the Royalty Agreement. The Company will estimate the payments to be made to HCRP over the term of the Agreement based on forecasted royalties and will calculate the interest rate required to discount such payments back to the liability balance. Over the course of the Royalty Agreement, the actual interest rate will be affected by the amount and timing of net royalty revenue recognized and changes in forecasted revenue. On a quarterly basis, the Company will reassess the effective interest rate and adjust the rate prospectively as necessary.

The following table shows the activity within the liability account for September 30, 2019 and December 31, 2018, respectively:

(In thousands)	September 30, 2019			December 31, 2018
Liability related to sale of future royalties - beginning balance	$	30,716		$	35,788
Deferred transaction costs recognized		495			784
Non-cash royalty revenue payable to HCRP		(7,556	)		(10,291	)
Non-cash interest expense recognized		2,593			4,435
Liability related to sale of future royalties - ending balance	$	26,248		$	30,716

Convertible Senior Notes

9 Months Ended

Sep. 30, 2019

Debt Disclosure [Abstract]

Convertible Senior Notes

(11) Convertible Senior Notes

On June 17, 2014, the Company issued $345 million aggregate principal amount of 1.75% Convertible Senior Notes due 2021 (the Notes) in an underwritten public offering. The net proceeds from the offering were $337.5 million after deducting the Underwriter’s discount and offering expenses paid by the Company.

The Notes are convertible into cash, shares of the Company’s common stock or a combination of cash and shares of the Company’s common stock, at the Company’s election, under certain circumstances as outlined in the indenture, based on an initial conversion rate, subject to adjustment, of 23.4968 shares per $1,000 principal amount of Notes (representing an initial conversion price of approximately $42.56 per share).

The Company may redeem for cash all or part of the Notes, at the Company’s option, after June 20, 2017, under certain circumstances as outlined in the indenture.

The Company pays 1.75% interest per annum on the principal amount of the Notes, payable semiannually in arrears in cash on June 15 and December 15 of each year. The Notes will mature on June 15, 2021.

If the Company undergoes a “fundamental change” (as defined in the Indenture), subject to certain conditions, holders may require the Company to repurchase for cash all or part of their Notes in principal amounts of $1,000 or an integral multiple thereof. The Indenture contains customary terms and covenants and events of default. If an event of default (other than certain events of bankruptcy, insolvency or reorganization involving the Company) occurs and is continuing, the Trustee by notice to the Company, or the holders of at least 25% in principal amount of the outstanding Notes by notice to the Company and the Trustee, may declare 100% of the principal of and accrued and unpaid interest, if any, on all the Notes to be due and payable. Upon such a declaration of acceleration, such principal and accrued and unpaid interest, if any, will be due and payable immediately. Upon the occurrence of certain events of bankruptcy, insolvency or reorganization involving the Company, 100% of the principal and accrued and unpaid interest, if any, on all of the Notes will become due and payable automatically. Notwithstanding the foregoing, the Indenture provides that, to the extent the Company elects and for up to 270 days, the sole remedy for an event of default relating to certain failures by the Company to comply with certain reporting covenants in the Indenture consists exclusively of the right to receive additional interest on the Notes.

The Notes will be senior unsecured obligations and will rank equally with all of the Company’s existing and future senior debt and senior to any of the Company’s subordinated debt. The Notes will be structurally subordinated to all existing or future indebtedness and other liabilities (including trade payables) of the Company’s subsidiaries and will be effectively subordinated to the Company’s existing or future secured indebtedness to the extent of the value of the collateral. The Indenture does not limit the amount of debt that the Company or its subsidiaries may incur.

In accounting for the issuance of the Notes, the Company separated the Notes into liability and equity components. The carrying amount of the liability component was calculated by measuring the fair value of a similar liability that does not have an associated convertible feature. The carrying amount of the equity component representing the conversion option was determined by deducting the fair value of the liability component from the par value of the Notes as a whole. The equity component is not re-measured as long as it continues to meet the conditions for equity classification.

The outstanding note balance as of September 30, 2019 and December 31, 2018 consisted of the following:

(In thousands)	September 30, 2019			December 31, 2018
Liability component:
Principal	$	345,000		$	345,000
Less: debt discount and debt issuance costs, net		(18,619	)		(26,330	)
Net carrying amount	$	326,381		$	318,670
Equity component	$	61,195		$	61,195

In connection with the issuance of the Notes, the Company incurred approximately $7.5 million of debt issuance costs, which primarily consisted of underwriting, legal and other professional fees, and allocated these costs to the liability and equity components based on the allocation of the proceeds. Of the total $7.5 million of debt issuance costs, $1.3 million were allocated to the equity component and recorded as a reduction to additional paid-in capital and $6.2 million were allocated to the liability component and recorded as a reduction in the carrying amount of the debt liability on the balance sheet. The portion allocated to the liability component is amortized to interest expense over the expected life of the Notes using the effective interest method.

As of September 30, 2019, the remaining contractual life of the Notes is approximately 2 years. The effective interest rate on the liability component was approximately 4.8% for the period from the date of issuance through September 30, 2019.

The following table sets forth total interest expense recognized related to the Notes for the three and nine-month periods ended September 30, 2019 and 2018:

(In thousands)	Three-month period ended September 30, 2019		Three-month period ended September 30, 2018		Nine-month period ended September 30, 2019		Nine-month period ended September 30, 2018
Contractual interest expense	$	1,509	$	1,509	$	4,528	$	4,528
Amortization of debt issuance costs		241		229		713		680
Amortization of debt discount		2,360		2,252		6,997		6,675
Total interest expense	$	4,110	$	3,990	$	12,238	$	11,883

Leases

9 Months Ended

Sep. 30, 2019

Leases [Abstract]

Leases

(12) Leases

In February 2016, the FASB issued ASU 2016-02, “Leases” Topic 842, which amends the guidance in former ASC Topic 840, Leases. The new standard increases transparency and comparability most significantly by requiring the recognition by lessees of right-of-use (“ROU”) assets and lease liabilities on the balance sheet for all leases longer than 12 months. Under the standard, disclosures are required to meet the objective of enabling users of financial statements to assess the amount, timing, and uncertainty of cash flows arising from leases. For lessees, leases will be classified as finance or operating, with classification affecting the pattern and classification of expense recognition in the income statement.

The Company adopted the new lease guidance effective January 1, 2019 using the modified retrospective transition approach, applying the new standard to all of its leases existing at the date of initial application which is the effective date of adoption. Consequently, financial information will not be updated and the disclosures required under the new standard will not be provided for dates and periods before January 1, 2019. We elected the package of practical expedients which permits us to not reassess (1) whether any expired or existing contracts are or contain leases, (2) the lease classification for any expired or existing leases, and (3) any initial direct costs for any existing leases as of the effective date. We did not elect the hindsight practical expedient which permits entities to use hindsight in determining the lease term and assessing impairment. The adoption of the lease standard did not change our previously reported consolidated statements of operations and did not result in a cumulative catch-up adjustment to opening equity. The adoption of the new guidance resulted in the recognition of ROU assets of $28.0 million and lease liabilities of $35.1 million at January 1, 2019. The difference between the ROU assets and the lease liabilities is primarily due to unamortized initial direct costs, lease incentives and deferred rent related to the Company’s operating leases at December 31, 2018.

The interest rate implicit in lease contracts is typically not readily determinable. As such, the Company utilizes its incremental borrowing rate, which is the rate incurred to borrow on a collateralized basis over a similar term an amount equal to the lease payments in a similar economic environment. In calculating the present value of the lease payments, the Company elected to utilize its incremental borrowing rate based on the remaining lease terms as of the January 1, 2019 adoption date.

Operating lease ROU assets and operating lease liabilities are recognized based on the present value of the future minimum lease payments over the lease term at the commencement date. The operating lease ROU asset also includes any lease payments made and excludes lease incentives and initial direct costs incurred, if any. Our leases have remaining lease terms of 2 years to 8 years, some of which include options to extend the lease term for up to 15 years, and some of which include options to terminate the lease within 2 years.

The Company has elected the practical expedient to combine lease and non-lease components as a single component. The lease expense is recognized over the expected term on a straight-line basis. Operating leases are recognized on the balance sheet as right-of-use assets, current operating lease liabilities and non-current operating lease liabilities.

The new standard also provides practical expedients and certain exemptions for an entity’s ongoing accounting. We have elected the short-term lease recognition exemption for all leases that qualify. This means, for those leases where the initial lease term is one year or less or for which the ROU asset at inception is deemed immaterial, we will not recognize ROU assets or lease liabilities. Those leases are expensed on a straight line basis over the term of the lease.

Operating Leases

We lease certain office space, manufacturing and warehouse space under arrangements classified as leases under ASC 842. Leases with an initial term of 12 months or less are not recorded on the balance sheet; we recognize lease expense for these leases on a straight-line basis over the lease term. Most leases include one or more options to renew, with renewal options ranging from 5 to 15 years. The exercise of lease renewal options is at our sole discretion. One of our leases also includes an option to early terminate the lease within 2 years.

Ardsley, New York

In June 2011, the Company entered into a 15-year lease for an aggregate of approximately 138,000 square feet of office and laboratory space in Ardsley, New York. In 2014, the Company exercised its option to expand into an additional 25,405 square feet of office space, which the Company occupied in January 2015. The Company has options to extend the term of the lease for three additional five-year periods, and the Company has an option to terminate the lease after 10 years subject to payment of an early termination fee. Also, the Company has a right of first refusal until mid-2020 to lease up to approximately 95,000 additional square feet of space in additional buildings at the same location. The Company’s extension, early termination, and expansion rights are subject to specified terms and conditions, including specified time periods when they must be exercised, and are also subject to limitations including that the Company not be in default under the lease.

The Ardsley lease provides for monthly payments of rent during the lease term. These payments consist of base rent, which takes into account the costs of the facility improvements funded by the facility owner prior to the Company’s occupancy, and additional rent covering customary items such as charges for utilities, taxes, operating expenses, and other facility fees and charges. The base rent is currently $4.7 million per year, which reflects an annual 2.5% escalation factor.

Chelsea, Massachusetts

Through our Civitas subsidiary, we lease a manufacturing facility in Chelsea, Massachusetts with commercial-scale capabilities. The approximately 90,000 square foot facility also includes office and laboratory space. Civitas leases this facility from North River Everett Ave, LLC pursuant to a lease with a term that expires on December 31, 2025, and Civitas has two additional extension options of five years each. The base rent under the lease is currently $1.6 million per year, which reflects an annual escalation factor of 2.5% as well as an amendment to the lease to add additional property at the Chelsea, Massachusetts site as further described below.

In 2017, the Company’s Civitas subsidiary amended its existing Chelsea, Massachusetts lease. The amendment added expansion property located in Chelsea, Massachusetts next to the existing facility. The additional property includes land being used for parking and a free-standing warehouse building on the same site. The base rent for the additional property under the lease included in the rent number above, is currently $0.5 million per year with an annual escalation factor of 3.0%.

In 2018, the Company initiated a renovation and expansion of a building within the Chelsea manufacturing facility that will increase the size of the facility to approximately 95,000 square feet. The project will add a new manufacturing production line for Inbrija and other ARCUS products that has greater capacity than the existing manufacturing line, and it will create additional warehousing space for manufactured product. Pursuant to a 2018 lease amendment that enabled the renovation and expansion, upon completion of the project, annual rent under the lease will increase to $1.7 million. Construction of the project was substantially completed in October 2019, but it will take additional time to obtain the FDA approval needed to use the new production line for commercial manufacturing. All costs to renovate and expand the facility are borne by the Company, therefore, the lease for that building is accounted for as a build to suit lease.

Additional Facilities

In October 2016, we entered into a 10-year lease agreement with a term commencing January 1, 2017, for approximately 26,000 square feet of lab and office space in Waltham, MA. The lease provides for monthly rental payments over the lease term. The base rent under the lease is currently $1.1 million per year.

Our leases have remaining lease terms of 2 years to 8 years which assumes exercise of the early termination of our Ardsley, NY lease. We do not include any renewal options in our lease terms when calculating our lease liabilities as we are not reasonably certain that we will exercise these options. One of our leases includes the early termination option in the lease

term when calculating the lease liability. The weighted-average remaining lease term for our operating leases was 5 years at September 30, 2019. The weighted-average discount rate was 7.13% at September 30, 2019.

ROU assets and lease liabilities related to our operating leases are as follows:

(In thousands)	Balance Sheet Classification	September 30, 2019
Right-of-use assets	Right of use assets	$	24,675
Current lease liabilities	Current portion of lease liabilities		7,696
Non-current lease liabilities	Non-current portion of lease liabilities		24,393

We have lease agreements that contain both lease and non-lease components. We account for lease components together with non-lease components (e.g., common-area maintenance). The components of lease costs were as follows:

(In thousands)	Three-month period ended September 30, 2019		Nine-month period ended September 30, 2019
Operating lease cost	$	1,776	$	5,293
Variable lease cost		1,119		3,544
Short-term lease cost		440		1,094
Total lease cost	$	3,335	$	9,931

Future minimum commitments under all non-cancelable operating leases are as follows:

(In thousands)
2019 (excluding the nine months ended Sep 30, 2019)	$	1,902
2020		7,746
2021		7,935
2022		9,972
2023		3,043
Later years		7,666
Total lease payments		38,264
Less: Imputed interest		(6,175	)
Present value of lease liabilities	$	32,089

Supplemental cash flow information and non-cash activity related to our operating leases are as follows:

(In thousands)	Nine-month period ended September 30, 2019
Operating cash flow information:
Cash paid for amounts included in the measurement of lease liabilities	$	5,605
Non-cash activity:
Right-of-use assets obtained in exchange for lease obligations	$	770

Commitments and Contingencies

9 Months Ended

Sep. 30, 2019

Commitments And Contingencies Disclosure [Abstract]

Commitments and Contingencies

(13) Commitments and Contingencies

The Company is currently party to various legal proceedings which are principally patent litigation matters. The Company has assessed such legal proceedings and does not believe that it is probable that a liability has been incurred or that the amount of any potential liability or range of losses can be reasonably estimated. As a result, the Company did not record any loss contingencies for any of these matters. Litigation expenses are expensed as incurred.

Summary of Significant Accounting Policies (Policies)

9 Months Ended

Sep. 30, 2019

Accounting Policies [Abstract]

Restricted Cash

The following table provides a reconciliation of cash, cash equivalents, and restricted cash reported within the statement of financial position that sum to the total of the same amounts shown in the statement of cash flows:

	Nine-month period ended September 30, 2019				Nine-month period ended September 30, 2018
(In thousands)	Beginning of period		End of period		Beginning of period		End of period
Cash and cash equivalents	$	293,564	$	119,521	$	307,068	$	321,011
Restricted cash		532		387		410		365
Restricted cash included in Other assets		255		256		561		255
Total Cash, cash equivalents and restricted cash per statement of cash flows	$	294,351	$	120,164	$	308,039	$	321,631

Amounts included in restricted cash represent those amounts required to be set aside to cover the Company’s self-funded employee health insurance. Restricted cash included in other assets on the statement of financial position relates to cash collateralized standby letters of credit in connection with obligations under facility leases, which is included with other assets in the consolidated balance sheet due to the long-term nature of the letters of credit.

Inventory

The major classes of inventory were as follows:

(In thousands)	September 30, 2019		December 31, 2018
Raw materials	$	996	$	—
Work-in-progress		15,561		—
Finished goods		10,839		29,014
Total	$	27,396	$	29,014

The Company reviews inventory, including inventory purchase commitments, for slow moving or obsolete amounts based on expected product sales volume and provides reserves against the carrying amount of inventory as appropriate.

Foreign Currency Translation

The functional currency of operations outside the United States of America is deemed to be the currency of the local country, unless otherwise determined that the United States dollar would serve as a more appropriate functional currency given the economic operations of the entity. Accordingly, the assets and liabilities of the Company’s foreign subsidiary, Biotie, are translated into United States dollars using the period-end exchange rate; income and expense items are translated using the average exchange rate during the period; and equity transactions are translated at historical rates. Cumulative translation adjustments are reflected as a separate component of equity. Foreign currency transaction losses and gains are recognized in the period incurred and are reported as other (expense) income, net in the statement of operations.

Segment and Geographic Information

The Company is managed and operated as one business which is focused on developing therapies that restore function and improve the lives of people with neurological disorders. The entire business is managed by a single management team that reports to the Chief Executive Officer. The Company does not operate separate lines of business with respect to any of its products or product candidates and the Company does not prepare discrete financial information with respect to separate products or product candidates or by location. Accordingly, the Company views its business as one reportable operating segment. Net product revenues reported are derived from the sales of Inbrija in the U.S. for the three and nine-month periods ended September 30, 2019 and from the sales of Ampyra in the U.S. for the three and nine-month periods ended September 30, 2019 and 2018.

Goodwill

Goodwill represents the amount of consideration paid in excess of the fair value of net assets acquired in a business combination accounted for using the acquisition method of accounting. Goodwill is not amortized and is subject to impairment testing on an annual basis or when a triggering event occurs that may indicate the carrying value of the goodwill is impaired. We perform our impairment testing at the reporting level where we have determined that we have a single reporting unit and operating segment. The impairment test for goodwill uses an approach which compares the estimated fair value of the reporting unit including goodwill to its carrying value. If the carrying value of the reporting unit exceeds the estimated fair value of the reporting unit, an impairment loss is recognized in an amount equal to the excess of the carrying value over the estimated fair value.

During the second quarter of 2019, we experienced a significant decline in our stock price that reduced the market capitalization below the carrying value of the Company. This circumstance required the Company to perform a quantitative assessment to assess the value of the goodwill for impairment. The Company performed an assessment of the goodwill and concluded that there was no impairment. During the third quarter of 2019, we experienced a further significant decline in our stock price that reduced the market capitalization below the carrying value of the Company. The Company performed a quantitative assessment of the goodwill and concluded that there was an impairment to the goodwill. The Company utilized the income approach in the goodwill assessment process. The determination of the fair value of the reporting unit requires us to make significant estimates and assumptions. This valuation approach considers a number of factors that include, but are not limited to, prospective financial information, growth rates, terminal value, and discount rates and require us to make certain assumptions and estimates. When performing our income approach, we incorporate the use of projected financial

information and a discount rate that are developed based on certain assumptions. Due to the inherent uncertainty involved in making these estimates, actual results could differ from those estimates. The Company then corroborates the reasonableness of the total fair value of the reporting unit by reconciling the aggregate fair value of the reporting unit to the Company’s total market capitalization adjusted to include an estimated control premium. The estimated control premium is derived from reviewing observable transactions involving the purchase of controlling interests in comparable companies. The market capitalization is calculated using the relevant shares outstanding and the closing stock price at the test date. After completing our impairment assessment during the third quarter of 2019, we concluded that the carrying value of the Company exceeded its estimated fair value as of September 30, 2019 and therefore, the goodwill was fully impaired. The Company recorded an impairment charge of $277.6 million for the three and nine-month periods ended September 30, 2019 in the statement of operations.

Impairment of Long-Lived Assets

The Company continually evaluates whether events or circumstances have occurred that indicate that the estimated remaining useful lives of its long-lived assets, including identifiable intangible assets subject to amortization and property plant and equipment, may warrant revision or that the carrying value of the assets may be impaired. Factors the Company considers important that could trigger an impairment review include significant changes in the use of any assets, changes in historical trends in operating performance, changes in projected operating performance, stock price, loss of a major customer and significant negative economic trends. The decline in the trading price of the Company's common stock during the quarter ended September 30, 2019, and related decrease in the Company's market capitalization, was determined to be a triggering event in connection with the Company's review of the recoverability of its long-lived assets for the three-month period ended September 30, 2019. The Company performed a recoverability test during the third quarter of fiscal 2019 using the undiscounted cash flows, which are the sum of the future undiscounted cash flows expected to be derived from the direct use of the long-lived assets to the carrying value of the long-lived assets. Estimates of future cash flows were based on the Company’s own assumptions about its own use of the long-lived assets. The cash flow estimation period was based on the long-lived assets’ estimated remaining useful life to the Company. After performing the recoverability test, the Company determined that the undiscounted cash flows exceeded the carrying value and the long-lived assets were not impaired. Changes in these assumptions and resulting valuations or further declines in our stock price could result in future long-lived asset impairment charges. Management will continue to monitor any changes in circumstances for indicators of impairment. Any write‑downs are treated as permanent reductions in the carrying amount of the assets.

Subsequent Events

Subsequent events are defined as those events or transactions that occur after the balance sheet date, but before the financial statements are filed with the Securities and Exchange Commission. The Company completed an evaluation of the impact of any subsequent events through the date these financial statements were issued, and determined the following subsequent event that required disclosure in these financial statements.

On October 23, 2019, we announced a corporate restructuring to reduce costs and focus our resources on the commercial launch of Inbrija, which is our key strategic priority for the remainder of 2019. As part of the restructuring, we are reducing headcount by approximately 25% through a reduction in force. The majority of the reduction took place in the fourth quarter of 2019 immediately after the announcement, and the remainder will be completed by the first quarter of 2020.

Accounting Pronouncements Adopted

In February 2016, the FASB issued ASU 2016-02, “Leases” Topic 842, which amends the guidance in former ASC Topic 840, Leases. The new standard increases transparency and comparability most significantly by requiring the recognition by lessees of right-of-use (“ROU”) assets and lease liabilities on the balance sheet for all leases longer than 12 months. Under the standard, disclosures are required to meet the objective of enabling users of financial statements to assess the amount, timing, and uncertainty of cash flows arising from leases. For lessees, leases will be classified as finance or operating, with classification affecting the pattern and classification of expense recognition in the income statement.

The Company adopted the new lease guidance effective January 1, 2019 using the modified retrospective transition approach, applying the new standard to all of its leases existing at the date of initial application which is the effective date of adoption. Consequently, financial information will not be updated and the disclosures required under the new standard will not be provided for dates and periods before January 1, 2019. We elected the package of practical expedients which permits us to not reassess (1) whether any expired or existing contracts are or contain leases, (2) the lease classification for any

expired or existing leases, and (3) any initial direct costs for any existing leases as of the effective date. We did not elect the hindsight practical expedient which permits entities to use hindsight in determining the lease term and assessing impairment. The adoption of the lease standard did not change our previously reported consolidated statements of operations and did not result in a cumulative catch-up adjustment to opening equity. See Note 12 for further information.

In August 2018, the Securities Exchange Commission (“SEC”) adopted the final rule under SEC Release No. 33-10532, Disclosure Update and Simplification, amending certain disclosure requirements that were redundant, duplicative, overlapping, outdated or superseded. In addition, the amendments expanded the disclosure requirements on the analysis of stockholders’ equity for interim financial statements. Under the amendments, an analysis of changes in each caption of stockholders’ equity presented in the balance sheet must be provided in a note or separate statement. The analysis should present a reconciliation of the beginning balance to the ending balance of each period for which a statement of comprehensive income is required to be filed. The Company adopted the rule in the three-month period ended March 31, 2019 and included its first presentation of changes in stockholders’ equity in its Form 10-Q for the three-month period ended March 31, 2019.

In February 2018, the FASB issued ASU 2018-02, “Income Statement—Reporting Comprehensive Income” (Topic 220): Reclassification of Certain Tax Effects from Accumulated Other Comprehensive Income (ASU 2018-02). This new standard provides entities with an option to reclassify stranded tax effects within AOCI to retained earnings in each period in which the effect of the change in the U.S. federal corporate income tax rate in the Tax Cuts and Jobs Act (or portion thereof) is recorded. The reclassification is the difference between the amount previously recorded in other comprehensive income at the historical U.S. federal tax rate that remains in accumulated other comprehensive loss at the time the Act was effective and the amount that would have been recorded using the newly enacted rate. This guidance became effective in Q1 2019; however, the Company did not elect to make the optional reclassification.

In July 2018, the FASB issued ASU 2018-09, “Codification Improvements.” The ASU’s amendments clarify, correct errors in, or make minor improvements to a variety of ASC topics. The changes in ASU 2018-09 are not expected to have a significant effect on current accounting practices. Some of the amendments in this update do not require transition guidance and will be effective upon issuance of this update. However, many of the amendments in this update do have transition guidance with effective dates for annual periods beginning after December 15, 2018, for public business entities. The ASU became effective in Q1 2019. The ASU did not have a significant impact on its consolidated financial statements.

In January 2017, the FASB issued ASU 2017-04, “Intangibles – Goodwill and Other” (Topic 350): Simplifying the Test for Goodwill Impairment (ASU 2017-04). This new standard simplifies how an entity is required to test goodwill for impairment by eliminating Step 2 from the goodwill impairment test. ASU 2017-04 allows for prospective application and is effective for fiscal years beginning after December 15, 2019, and interim periods therein with early adoption permitted for interim or annual goodwill impairment tests performed on testing dates after January 1, 2017. The Company adopted this guidance on April 1, 2019. The ASU did not have an impact upon adoption on its consolidated financial statements.

Accounting Pronouncements Not Yet Adopted

In June 2016, the FASB issued ASU 2016-13, “Financial Instruments – Credit Losses” (Topic 326): Measurement of Credit Losses on Financial Instruments and subsequently amended by ASU 2019-04 and ASU 2019-05 which introduces a forward-looking approach, based on expected losses, to estimate credit losses on certain types of financial instruments, including trade receivables. This new standard amends the current guidance on the impairment of financial instruments. The ASU adds to U.S. GAAP an impairment model known as current expected credit loss (CECL) model that is based on expected losses rather than incurred losses. Under the new guidance, an entity will recognize as an allowance its estimate of expected credit losses. The ASU is effective for fiscal years beginning after December 15, 2019, and interim periods within those fiscal years with early adoption permitted. The Company is currently evaluating the impact the adoption of this guidance may have on its consolidated financial statements and will adopt the guidance when effective.

In August 2018, the FASB issued ASU 2018-13 “Fair Value Measurement (Topic 820): “Disclosure Framework—Changes to the Disclosure Requirements for Fair Value Measurement.” The amendment in this ASU eliminate, add and modify certain disclosure requirements for fair value measurements as part of its disclosure framework project. Entities will no longer be required to disclose the amount of and reasons for transfers between Level 1 and Level 2 of the fair value hierarchy, but public business entities will be required to disclose the range and weighted average used to develop significant unobservable inputs for Level 3 fair value measurements. The ASU is effective for all entities for fiscal years beginning after December 15, 2019, and interim periods within those fiscal years with early adoption permitted. The Company is currently evaluating the impact the adoption of this guidance may have on its consolidated financial statements.

In August 2018, the FASB issued ASU 2018-15, “Customer’s Accounting for Implementation Costs Incurred in a Cloud Computing Arrangement That Is a Service Contract.” The ASU clarifies certain aspects of ASU 2015-05, “Customer’s Accounting for Fees Paid in a Cloud Computing Arrangement,” which was issued in April 2015. Specifically, the ASU 2018-15 aligns the requirements for capitalizing implementation costs incurred in a hosting arrangement that is a service contract with the requirements for capitalizing implementation costs incurred to develop or obtain internal-use software (and hosting arrangements that include an internal-use software license).” The ASU is effective for fiscal years beginning after December 15, 2019, and interim periods within those fiscal years with early adoption permitted. The Company is currently evaluating the impact the adoption of this guidance may have on its consolidated financial statements.

In November 2018, the FASB issued ASU 2018-18, Collaborative arrangements (Topic 808): Clarifying the Interaction Between Topic 808 and Topic 606. ASU 2018-18 clarifies that certain transactions between participants in a collaborative arrangement should be accounted for under ASC 606 when the counterparty is a customer and precludes an entity from presenting consideration from a transaction in a collaborative arrangement as revenue from contracts with customers if the counterparty is not a customer for that transaction. The ASU is effective for fiscal years beginning after December 15, 2019, and interim periods within those fiscal years with early adoption permitted. The Company is currently evaluating the impact the adoption of this guidance may have on its consolidated financial statements.

Summary of Significant Accounting Policies (Tables)

9 Months Ended

Sep. 30, 2019

Accounting Policies [Abstract]

Reconciliation of Cash, Cash Equivalents and Restricted Cash

The following table provides a reconciliation of cash, cash equivalents, and restricted cash reported within the statement of financial position that sum to the total of the same amounts shown in the statement of cash flows:

	Nine-month period ended September 30, 2019				Nine-month period ended September 30, 2018
(In thousands)	Beginning of period		End of period		Beginning of period		End of period
Cash and cash equivalents	$	293,564	$	119,521	$	307,068	$	321,011
Restricted cash		532		387		410		365
Restricted cash included in Other assets		255		256		561		255
Total Cash, cash equivalents and restricted cash per statement of cash flows	$	294,351	$	120,164	$	308,039	$	321,631

Schedule of Major Classes of Inventory

Inventory

The major classes of inventory were as follows:

(In thousands)	September 30, 2019		December 31, 2018
Raw materials	$	996	$	—
Work-in-progress		15,561		—
Finished goods		10,839		29,014
Total	$	27,396	$	29,014

Revenue (Tables)

9 Months Ended

Sep. 30, 2019

Revenue From Contract With Customer [Abstract]

Disaggregation of Revenue

The following table disaggregates our revenue by major source:

(In thousands)	Three-month period ended September 30, 2019		Three-month period ended September 30, 2018		Nine-month period ended September 30, 2019		Nine-month period ended September 30, 2018
Revenues:
Net product revenues:
Ampyra	$	37,647	$	137,815	$	122,383	$	390,900
Inbrija		4,889		—		9,164		—
Other		2,264		2,158		1,778		2,488
Total net product revenues		44,800		139,973		133,325		393,388
Royalty revenues		2,922		2,841		8,586		8,893
Total net revenues	$	47,722	$	142,814	$	141,911	$	402,281

Share-based Compensation (Tables)

9 Months Ended

Sep. 30, 2019

Share Based Compensation Arrangement By Share Based Payment Award [Line Items]

Schedule of Share-based Compensation Expense

The following table summarizes share-based compensation expense included within the consolidated statements of operations:

	For the three-month period ended September 30,				For the nine-month period ended September 30,
(In thousands)	2019		2018		2019		2018
Research and development expense	$	719	$	1,112	$	2,203	$	4,336
Selling, general and administrative expense		2,424		4,023		8,785		11,910
Cost of Sales		149		—		505		—
Total	$	3,292	$	5,135	$	11,493	$	16,246

Schedule of Stock Option Activity

A summary of share-based compensation activity for the nine-month period ended September 30, 2019 is presented below:

	Number of Shares (In thousands)			Weighted Average Exercise Price		Weighted Average Remaining Contractual Term		Intrinsic Value (In thousands)
Balance at January 1, 2019		8,194		$	29.81
Granted		640			12.16
Cancelled		(494	)		24.83
Exercised		(2	)		16.00
Balance at September 30, 2019		8,339		$	28.76		4.8	$	—
Vested and expected to vest at September 30, 2019		8,316		$	28.79		4.8	$	—
Vested and exercisable at September 30, 2019		7,165		$	30.23		4.2	$	—

Restricted Stock and Performance Stock Unit

Share Based Compensation Arrangement By Share Based Payment Award [Line Items]

Schedule of Restricted Stock and Performance Stock Unit Activity

(In thousands)
Restricted Stock and Performance Stock Units	Number of Shares
Nonvested at January 1, 2019		231
Granted		628
Vested		(96	)
Forfeited		(52	)
Nonvested at September 30, 2019		711

(Loss) Income Per Share (Tables)

9 Months Ended

Sep. 30, 2019

Earnings Per Share [Abstract]

Schedule of Computation of Basic and Diluted (Loss) Income per Share

The following table sets forth the computation of basic and diluted (loss) income per share for the three and nine-month periods ended September 30, 2019 and 2018:

(In thousands, except per share data)	Three-month period ended September 30, 2019			Three-month period ended September 30, 2018			Nine-month period ended September 30, 2019			Nine-month period ended September 30, 2018
Basic and diluted
Net (loss) income	$	(263,535	)	$	(13,911	)	$	(338,626	)	$	24,087
Weighted average common shares outstanding used in computing net (loss) income per share—basic		47,511			47,184			47,491			46,840
Plus: net effect of dilutive stock options and restricted common shares		—			—			—			411
Weighted average common shares outstanding used in computing net (loss) income per share—diluted		47,511			47,184			47,491			47,251
Net (loss) income per share—basic	$	(5.55	)	$	(0.29	)	$	(7.13	)	$	0.51
Net (loss) income per share—diluted	$	(5.55	)	$	(0.29	)	$	(7.13	)	$	0.51

Schedule of Anti-dilutive Securities Excluded from Calculation of Net Loss per Diluted Share

The following amounts were not included in the calculation of net loss per diluted share because their effects were anti-dilutive:

(In thousands)

Three-month period ended September 30, 2019

Three-month period ended September 30, 2018

Nine-month period ended September 30, 2019

Nine-month period ended September 30, 2018

Denominator

Stock options and restricted common shares

8,995

8,825

8,995

7,262

Goodwill (Tables)

9 Months Ended

Sep. 30, 2019

Goodwill [Abstract]

Summary of Activities in Goodwill

The following table represents a summary of activities in goodwill from December 31, 2018 through September 30, 2019:

(In thousands)
Balance at December 31, 2018	$	282,059
Impairment		(277,561	)
Foreign currency translation adjustment		(4,498	)
Balance at September 30, 2019	$	—

Fair Value Measurements (Tables)

9 Months Ended

Sep. 30, 2019

Schedule of Assets and Liabilities Measured at Fair Value on a Recurring Basis

(In thousands)	Level 1		Level 2		Level 3
September 30, 2019
Assets Carried at Fair Value:
Money market funds	$	28,899	$	—	$	—
U.S. government securities		2,500		13,246		—
Commercial paper		—		49,054		—
Corporate bonds		—		71,336		—
Liabilities Carried at Fair Value:
Acquired contingent consideration		—		—		111,200
December 31, 2018
Assets Carried at Fair Value:
Money market funds	$	9,586	$	—	$	—
Commercial paper		—		47,108		—
Corporate bonds		—		104,881		—
Liabilities Carried at Fair Value:
Acquired contingent consideration		—		—		168,000

Contingent Consideration Liability

Schedule of Contingent Liabilities

The following table presents additional information about liabilities measured at fair value on a recurring basis and for which the Company utilizes Level 3 inputs to determine fair value.

(In thousands)	Three-month period ended September 30, 2019			Three-month period ended September 30, 2018		Nine-month period ended September 30, 2019			Nine-month period ended September 30, 2018
Acquired contingent consideration:
Balance, beginning of period	$	162,537		$	112,200	$	168,000		$	113,000
Fair value change to contingent consideration included in the statement of operations		(50,942	)		22,700		(56,342	)		21,900
Royalty payments		(395	)		—		(458	)		—
Balance, end of period	$	111,200		$	134,900	$	111,200		$	134,900

Investments (Tables)

9 Months Ended

Sep. 30, 2019

Investments Debt And Equity Securities [Abstract]

Schedule of Available-for-Sale Securities

Available-for-sale investments consisted of the following at September 30, 2019 and December 31, 2018, respectively:

			Gross		Gross			Estimated
	Amortized		Unrealized		Unrealized			Fair
(In thousands)	Cost		Gains		Losses			Value
September 30, 2019
Commercial Paper	$	49,041	$	24	$	(11	)	$	49,054
Corporate Bonds		71,241		104		(9	)		71,336
U.S. government securities		13,250		—		(4	)		13,246
Total Short-term investments	$	133,532	$	128	$	(24	)	$	133,636
December 31, 2018
Commercial Paper	$	47,149	$	—	$	(41	)	$	47,108
Corporate Bonds		104,965		6		(90	)		104,881
Total Short-term investments	$	152,114	$	6	$	(131	)	$	151,989

Schedule of Changes in Accumulated Other Comprehensive (Loss) Income

The changes in AOCI associated with the unrealized holding gains on available-for-sale investments during the nine-month period ended September 30, 2019, were as follows (in thousands):

(In thousands)	Net Unrealized Gains (Losses) on Marketable Securities
Balance at December 31, 2018	$	(125	)
Other comprehensive income before reclassifications		229
Amounts reclassified from accumulated other comprehensive income		—
Net current period other comprehensive income		229
Balance at September 30, 2019	$	104

Liability Related to Sale of Future Royalties (Tables)

9 Months Ended

Sep. 30, 2019

Deferred Revenue Disclosure [Abstract]

Schedule of Activity Within Liability Related to Sale of Future Royalties

The following table shows the activity within the liability account for September 30, 2019 and December 31, 2018, respectively:

(In thousands)	September 30, 2019			December 31, 2018
Liability related to sale of future royalties - beginning balance	$	30,716		$	35,788
Deferred transaction costs recognized		495			784
Non-cash royalty revenue payable to HCRP		(7,556	)		(10,291	)
Non-cash interest expense recognized		2,593			4,435
Liability related to sale of future royalties - ending balance	$	26,248		$	30,716

Convertible Senior Notes (Tables)

9 Months Ended

Sep. 30, 2019

Debt Disclosure [Abstract]

Summary of Outstanding Note Balances

The outstanding note balance as of September 30, 2019 and December 31, 2018 consisted of the following:

(In thousands)	September 30, 2019			December 31, 2018
Liability component:
Principal	$	345,000		$	345,000
Less: debt discount and debt issuance costs, net		(18,619	)		(26,330	)
Net carrying amount	$	326,381		$	318,670
Equity component	$	61,195		$	61,195

Schedule of Interest Expense Recognized Related to the Notes

The following table sets forth total interest expense recognized related to the Notes for the three and nine-month periods ended September 30, 2019 and 2018:

(In thousands)	Three-month period ended September 30, 2019		Three-month period ended September 30, 2018		Nine-month period ended September 30, 2019		Nine-month period ended September 30, 2018
Contractual interest expense	$	1,509	$	1,509	$	4,528	$	4,528
Amortization of debt issuance costs		241		229		713		680
Amortization of debt discount		2,360		2,252		6,997		6,675
Total interest expense	$	4,110	$	3,990	$	12,238	$	11,883

- Definition

Tabular disclosure of long-debt instruments or arrangements, including identification, terms, features, collateral requirements and other information necessary to a fair presentation. These are debt arrangements that originally required repayment more than twelve months after issuance or greater than the normal operating cycle of the entity, if longer.

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+ Details

Leases (Tables)

9 Months Ended

Sep. 30, 2019

Leases [Abstract]

Schedule of ROU Assets and Lease Liabilities Related to Operating Leases

ROU assets and lease liabilities related to our operating leases are as follows:

(In thousands)	Balance Sheet Classification	September 30, 2019
Right-of-use assets	Right of use assets	$	24,675
Current lease liabilities	Current portion of lease liabilities		7,696
Non-current lease liabilities	Non-current portion of lease liabilities		24,393

Components of Lease Costs

The components of lease costs were as follows:

(In thousands)	Three-month period ended September 30, 2019		Nine-month period ended September 30, 2019
Operating lease cost	$	1,776	$	5,293
Variable lease cost		1,119		3,544
Short-term lease cost		440		1,094
Total lease cost	$	3,335	$	9,931

Schedule of Future Minimum Commitments under all Non-Cancelable Operating Leases

Future minimum commitments under all non-cancelable operating leases are as follows:

(In thousands)
2019 (excluding the nine months ended Sep 30, 2019)	$	1,902
2020		7,746
2021		7,935
2022		9,972
2023		3,043
Later years		7,666
Total lease payments		38,264
Less: Imputed interest		(6,175	)
Present value of lease liabilities	$	32,089

Summary of Supplemental Cash Flow Information and Non-Cash Activity Related to Operating Leases

Supplemental cash flow information and non-cash activity related to our operating leases are as follows:

(In thousands)	Nine-month period ended September 30, 2019
Operating cash flow information:
Cash paid for amounts included in the measurement of lease liabilities	$	5,605
Non-cash activity:
Right-of-use assets obtained in exchange for lease obligations	$	770

Summary of Significant Accounting Policies - Reconciliation of Cash, Cash Equivalents and Restricted Cash (Details) - USD ($) $ in Thousands	Sep. 30, 2019	Dec. 31, 2018	Sep. 30, 2018	Dec. 31, 2017
Accounting Policies [Abstract]
Cash and cash equivalents	$ 119,521	$ 293,564	$ 321,011	$ 307,068
Restricted cash	387	532	365	410
Restricted cash included in Other assets	$ 256	$ 255	$ 255	$ 561
Restricted cash, noncurrent, statement of financial position [extensible list]	us-gaap:OtherAssetsNoncurrent	us-gaap:OtherAssetsNoncurrent	us-gaap:OtherAssetsNoncurrent	us-gaap:OtherAssetsNoncurrent
Total Cash, cash equivalents and restricted cash per statement of cash flows	$ 120,164	$ 294,351	$ 321,631	$ 308,039

Summary of Significant Accounting Policies - Schedule of Major Classes of Inventory (Details) - USD ($) $ in Thousands	Sep. 30, 2019	Dec. 31, 2018
Inventory Disclosure [Abstract]
Raw materials	$ 996
Work-in-progress	15,561
Finished goods	10,839	$ 29,014
Total	$ 27,396	$ 29,014

Summary of Significant Accounting Policies - Additional Information (Details)	3 Months Ended		9 Months Ended
	Sep. 30, 2019 USD ($)	Jun. 30, 2019 USD ($)	Sep. 30, 2019 USD ($) Segment
Segment and Geographic Information
Number of operating segments			1
Number of reportable operating segments			1
Goodwill impairment \| $	$ 277,561,000	$ 0	$ 277,561,000
Restructuring activities, description			On October 23, 2019, we announced a corporate restructuring to reduce costs and focus our resources on the commercial launch of Inbrija
Approximate percentage of headcount reduction			25.00%

Revenue - Disaggregation of Revenue (Details) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2019	Sep. 30, 2018	Sep. 30, 2019	Sep. 30, 2018
Disaggregation Of Revenue [Line Items]
Total net revenues	$ 47,722	$ 142,814	$ 141,911	$ 402,281
Ampyra
Disaggregation Of Revenue [Line Items]
Total net revenues	37,647	137,815	122,383	390,900
Inbrija
Disaggregation Of Revenue [Line Items]
Total net revenues	4,889		9,164
Other
Disaggregation Of Revenue [Line Items]
Total net revenues	2,264	2,158	1,778	2,488
Net Product Revenues
Disaggregation Of Revenue [Line Items]
Total net revenues	44,800	139,973	133,325	393,388
Royalty Revenues
Disaggregation Of Revenue [Line Items]
Total net revenues	$ 2,922	$ 2,841	$ 8,586	$ 8,893

Share-based Compensation - Additional Information (Details) - USD ($) $ / shares in Units, $ in Thousands	3 Months Ended						9 Months Ended
	Sep. 30, 2019	Jun. 30, 2019	Mar. 31, 2019	Sep. 30, 2018	Jun. 30, 2018	Mar. 31, 2018	Sep. 30, 2019	Sep. 30, 2018
Disclosure Of Compensation Related Costs Sharebased Payments [Abstract]
Share-based compensation expense recognized	$ 3,292			$ 5,135			$ 11,493	$ 16,246
Weighted average fair value of options granted (in dollars per share)	$ 2.69			$ 12.39			$ 6.49	$ 12.81
Unrecognized compensation costs for unvested stock options, restricted stock awards and performance stock units	$ 17,100						$ 17,100
Unrecognized compensation costs, weighted average period							2 years 1 month 6 days
Repurchases of common stock, shares	0						7,360
Average price of common stock per share							$ 12.31
Repurchases of common stock		$ 39	$ 52		$ 385	$ 1,202	$ 91

Share-based Compensation - Schedule of Share-based Compensation Expense (Details) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2019	Sep. 30, 2018	Sep. 30, 2019	Sep. 30, 2018
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Share-based compensation expense recognized	$ 3,292	$ 5,135	$ 11,493	$ 16,246
Research and development expense
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Share-based compensation expense recognized	719	1,112	2,203	4,336
Selling, general, and administrative expense
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Share-based compensation expense recognized	2,424	$ 4,023	8,785	$ 11,910
Cost of sales
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Share-based compensation expense recognized	$ 149		$ 505

Share-based Compensation - Schedule of Stock Options Activity (Details) shares in Thousands	9 Months Ended
	Sep. 30, 2019 $ / shares shares
Stock Option Activity
Beginning balance (in shares) \| shares	8,194
Granted (in shares) \| shares	640
Cancelled (in shares) \| shares	(494)
Exercised (in shares) \| shares	(2)
Ending balance (in shares) \| shares	8,339
Vested and expected to vest at the end of the period \| shares	8,316
Vested and exercisable at the end of the period \| shares	7,165
Weighted Average Exercise Price
Balance at the beginning of the period (in dollars per share) \| $ / shares	$ 29.81
Granted (in dollars per share) \| $ / shares	12.16
Cancelled (in dollars per share) \| $ / shares	24.83
Exercised (in dollars per share) \| $ / shares	16.00
Balance at the end of the period (in dollars per share) \| $ / shares	28.76
Vested and expected to vest at the end of the period (in dollars per share) \| $ / shares	28.79
Vested and exercisable at the end of the period (in dollars per share) \| $ / shares	$ 30.23
Weighted Average Remaining Contractual Term
Balance at the end of the period	4 years 9 months 18 days
Vested and expected to vest at the end of the period	4 years 9 months 18 days
Vested and exercisable at the end of the period	4 years 2 months 12 days

Share-based Compensation - Schedule of Restricted Stock and Performance Stock Unit Activity (Details) - Restricted Stock and Performance Stock Unit shares in Thousands	9 Months Ended
	Sep. 30, 2019 shares
Restricted Stock and Performance Stock Units
Nonvested at the beginning of the period (in shares)	231
Granted (in shares)	628
Vested (in shares)	(96)
Forfeited (in shares)	(52)
Nonvested at the end of the period (in shares)	711

(Loss) Income Per Share - Schedule of Computation of Basic and Diluted (Loss) Income Per Share (Details) - USD ($) $ / shares in Units, shares in Thousands, $ in Thousands	3 Months Ended						9 Months Ended
	Sep. 30, 2019	Jun. 30, 2019	Mar. 31, 2019	Sep. 30, 2018	Jun. 30, 2018	Mar. 31, 2018	Sep. 30, 2019	Sep. 30, 2018
Basic and diluted
Net (loss) income	$ (263,535)	$ (27,486)	$ (47,605)	$ (13,911)	$ 46,197	$ (8,199)	$ (338,626)	$ 24,087
Weighted average common shares outstanding used in computing net (loss) income per share—basic	47,511			47,184			47,491	46,840
Plus: net effect of dilutive stock options and restricted common shares								411
Weighted average common shares outstanding used in computing net (loss) income per share—diluted	47,511			47,184			47,491	47,251
Net (loss) income per share—basic	$ (5.55)			$ (0.29)			$ (7.13)	$ 0.51
Net (loss) income per share—diluted	$ (5.55)			$ (0.29)			$ (7.13)	$ 0.51

- Definition

The amount of net income (loss) for the period per each share of common stock or unit outstanding during the reporting period.

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- Definition

The amount of net income (loss) for the period available to each share of common stock or common unit outstanding during the reporting period and to each share or unit that would have been outstanding assuming the issuance of common shares or units for all dilutive potential common shares or units outstanding during the reporting period.

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- Definition

The portion of profit or loss for the period, net of income taxes, which is attributable to the parent.

+ References + Details

(Loss) Income Per Share - Schedule of Antidilutive Securities Excluded from Calculation of Net Loss Per Diluted Share (Details) - shares shares in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2019	Sep. 30, 2018	Sep. 30, 2019	Sep. 30, 2018
Stock options and restricted common shares
Antidilutive Securities
Anti-dilutive securities excluded from computation of loss per share (in shares)	8,995	8,825	8,995	7,262

Income Taxes - Additional Information (Details) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2019	Sep. 30, 2018	Sep. 30, 2019	Sep. 30, 2018
Reconciliation of statutory federal income tax rate to effective income tax rate
Income tax provision (benefit)	$ 17	$ 37,968	$ (484)	$ 49,802
Effective income tax rate (as a percent)	0.00%	157.80%	0.14%	67.40%

Goodwill - Summary of Activities in Goodwill (Details) - USD ($)	3 Months Ended		9 Months Ended
	Sep. 30, 2019	Jun. 30, 2019	Sep. 30, 2019
Goodwill [Abstract]
Balance at December 31, 2018			$ 282,059,000
Impairment	$ (277,561,000)	$ 0	(277,561,000)
Foreign currency translation adjustment			(4,498,000)
Balance at September 30, 2019	$ 0.0		$ 0.0

Goodwill - Additional Information (Details) - USD ($)	3 Months Ended		9 Months Ended
Goodwill - Additional Information (Details) - USD ($)	Sep. 30, 2019	Jun. 30, 2019	Sep. 30, 2019	Dec. 31, 2018
Goodwill [Abstract]
Goodwill	$ 0.0		$ 0.0	$ 282,059,000
Goodwill impairment	$ 277,561,000	$ 0	$ 277,561,000

Fair Value Measurements - Additional Information (Details)	Sep. 30, 2019 USD ($)
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Milestone payment, minimum	$ 1,000,000.0
Milestone payment, maximum	59,000,000.0
Level 2
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Convertible senior notes	$ 264,300,000

Fair Value Measurements - Schedule of Assets and Liabilities Measured at Fair Value on a Recurring Basis (Details) - Recurring basis - USD ($) $ in Thousands	Sep. 30, 2019	Dec. 31, 2018
Level 1 \| Money Market Funds
Assets Carried at Fair Value:
Assets, Fair Value	$ 28,899	$ 9,586
Level 1 \| U.S. Government Securities
Assets Carried at Fair Value:
Assets, Fair Value	2,500
Level 2 \| U.S. Government Securities
Assets Carried at Fair Value:
Assets, Fair Value	13,246
Level 2 \| Commercial Paper
Assets Carried at Fair Value:
Assets, Fair Value	49,054	47,108
Level 2 \| Corporate Bonds
Assets Carried at Fair Value:
Assets, Fair Value	71,336	104,881
Level 3
Liabilities Carried at Fair Value:
Acquired contingent consideration	$ 111,200	$ 168,000

Fair Value Measurements - Schedule of Contingent Liabilities (Details) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2019	Sep. 30, 2018	Sep. 30, 2019	Sep. 30, 2018
Assets and liabilities measured at fair value on a recurring basis utilizing Level 3 inputs
Balance, beginning of period	$ 162,537	$ 112,200	$ 168,000	$ 113,000
Fair value change to contingent consideration included in the statement of operations	(50,942)	22,700	(56,342)	21,900
Royalty payments	(395)		(458)
Balance, end of period	$ 111,200	$ 134,900	$ 111,200	$ 134,900

Investments - Schedule of Available-for-Sale Securities (Details) - USD ($) $ in Thousands	Sep. 30, 2019	Dec. 31, 2018
Schedule Of Available For Sale Securities [Line Items]
Amortized Cost	$ 133,532	$ 152,114
Gross Unrealized Gains	128	6
Gross Unrealized Losses	(24)	(131)
Estimated Fair Value	133,636	151,989
Commercial Paper
Schedule Of Available For Sale Securities [Line Items]
Amortized Cost	49,041	47,149
Gross Unrealized Gains	24
Gross Unrealized Losses	(11)	(41)
Estimated Fair Value	49,054	47,108
Corporate Bonds
Schedule Of Available For Sale Securities [Line Items]
Amortized Cost	71,241	104,965
Gross Unrealized Gains	104	6
Gross Unrealized Losses	(9)	(90)
Estimated Fair Value	71,336	$ 104,881
U.S. Government Securities
Schedule Of Available For Sale Securities [Line Items]
Amortized Cost	13,250
Gross Unrealized Losses	(4)
Estimated Fair Value	$ 13,246

Investments - Additional Information (Details) - USD ($)	Sep. 30, 2019	Dec. 31, 2018
Schedule Of Available For Sale Securities [Line Items]
Long-term investments	$ 0	$ 0
Short-term investments	133,636,000	151,989,000
Short-term investments classified as cash equivalents	31,400,000	$ 9,600,000
Short Term Investments
Schedule Of Available For Sale Securities [Line Items]
Fair value of short-term investments in an unrealized loss position	$ 48,700,000

Investments - Schedule of Changes in Accumulated Other Comprehensive (loss) Income (Details) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2019	Sep. 30, 2018	Sep. 30, 2019	Sep. 30, 2018
Accumulated Other Comprehensive Income Loss [Line Items]
Balance at December 31, 2018			$ 2,806
Other comprehensive loss, net of tax	$ (3,253)	$ (686)	(3,442)	$ (2,745)
Balance at September 30, 2019	(636)		(636)
Net Unrealized Gains (Losses) on Marketable Securities
Accumulated Other Comprehensive Income Loss [Line Items]
Balance at December 31, 2018			(125)
Other comprehensive income before reclassifications			229
Other comprehensive loss, net of tax			229
Balance at September 30, 2019	$ 104		$ 104

Liability Related to Sale of Future Royalties - Additional Information (Details) - Royalty Purchase Agreement - USD ($) $ in Thousands		9 Months Ended	12 Months Ended
	Oct. 01, 2017	Sep. 30, 2019	Dec. 31, 2018
Liability Related To Sale Of Future Royalties [Line Items]
Payment from royalties	$ 40,000
Royalty liability	40,000
Transaction costs	$ 2,200	$ 495	$ 784

Liability Related to Sale of Future Royalties - Schedule of Activity Within Liability Related to Sale of Future Royalties (Details) - USD ($) $ in Thousands		9 Months Ended		12 Months Ended
	Oct. 01, 2017	Sep. 30, 2019	Sep. 30, 2018	Dec. 31, 2018
Liability Related To Sale Of Future Royalties [Line Items]
Non-cash royalty revenue payable to HCRP		$ (7,556)	$ (7,826)
Royalty Purchase Agreement
Liability Related To Sale Of Future Royalties [Line Items]
Liability related to sale of future royalties - beginning balance		30,716	$ 35,788	$ 35,788
Deferred transaction costs recognized	$ 2,200	495		784
Non-cash royalty revenue payable to HCRP		(7,556)		(10,291)
Non-cash interest expense recognized		2,593		4,435
Liability related to sale of future royalties - ending balance		$ 26,248		$ 30,716

Convertible Senior Notes - Additional Information (Details) - Notes $ / shares in Units, $ in Thousands		9 Months Ended
	Jun. 17, 2014 USD ($)	Sep. 30, 2019 USD ($) $ / shares	Dec. 31, 2018 USD ($)
Debt Instrument [Line Items]
Interest rate (as a percent)	1.75%
Net proceeds from offering, after deducting Underwriter's discount and estimated offering expenses payable	$ 337,500
Principal	$ 345,000	$ 345,000	$ 345,000
Notes maturity date		Jun. 15, 2021
Notes frequency of periodic payment		semiannually in arrears in cash
Period to comply with covenants		270 days
Debt issuance costs		$ 7,500
Debt issuance costs allocated to equity component		1,300
Debt issuance costs allocated to liability component		$ 6,200
Remaining contractual life		2 years
Effective interest rate on liability component (as a percent)		4.80%
Debt Conversion Terms upon Occurrence of Certain Fundamental Company Changes
Debt Instrument [Line Items]
Principal amount of Notes or an integral multiple thereof in which holder may repurchase the Notes		$ 1,000
Debt Conversion Event Term
Debt Instrument [Line Items]
Minimum percentage of aggregate principal amount held by bondholders to declare notes due and payable		25.00%
In event of default arising out of certain bankruptcy events, percentage of principal amount due and payable		100.00%
Convertible Debt Holder
Debt Instrument [Line Items]
Initial conversion rate of common stock		23.4968
Initial conversion price of convertible notes into common stock (in dollars per share) \| $ / shares		$ 42.56

Convertible Senior Notes - Summary of Outstanding Note Balances (Details) - Notes - USD ($) $ in Thousands	Sep. 30, 2019	Dec. 31, 2018	Jun. 17, 2014
Debt Instrument [Line Items]
Principal	$ 345,000	$ 345,000	$ 345,000
Less: debt discount and debt issuance costs, net	(18,619)	(26,330)
Net carrying amount	326,381	318,670
Equity component	$ 61,195	$ 61,195

Convertible Senior Notes - Schedule of Interest Expense Recognized Related to the Notes (Details) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2019	Sep. 30, 2018	Sep. 30, 2019	Sep. 30, 2018
Debt Instrument [Line Items]
Total interest expense	$ 4,500	$ 5,415	$ 16,302	$ 16,326
Notes
Debt Instrument [Line Items]
Contractual interest expense	1,509	1,509	4,528	4,528
Amortization of debt issuance costs	241	229	713	680
Amortization of debt discount	2,360	2,252	6,997	6,675
Total interest expense	$ 4,110	$ 3,990	$ 12,238	$ 11,883

Leases - Additional Information (Details) $ in Thousands	9 Months Ended
Leases - Additional Information (Details) $ in Thousands	Sep. 30, 2019 USD ($) ft² Item	Jan. 01, 2019 USD ($)	Dec. 31, 2018 USD ($) ft²	Dec. 31, 2017 USD ($)	Oct. 31, 2016 USD ($) ft²	Dec. 31, 2014 ft²	Jun. 30, 2011 ft²
Operating Lease Information
ROU assets	$ 24,675
Lease liabilities	$ 32,089
Operating lease description	Operating lease ROU assets and operating lease liabilities are recognized based on the present value of the future minimum lease payments over the lease term at the commencement date. The operating lease ROU asset also includes any lease payments made and excludes lease incentives and initial direct costs incurred, if any. Our leases have remaining lease terms of 2 years to 8 years, some of which include options to extend the lease term for up to 15 years, and some of which include options to terminate the lease within 2 years.
Operating lease renewal option	true
Operating lease termination option	true
Termination option period	2 years
Operating lease renewal term, description	one or more options to renew, with renewal options ranging from 5 to 15 years
Operating lease termination option	One of our leases also includes an option to early terminate the lease within 2 years
Operating lease weighted-average remaining lease term	5 years
Operating lease weighted-average discount rate	7.13%
Ardsley, New York \| Office and Laboratory Space
Operating Lease Information
Operating lease renewal option	true
Lease option to extend term	5 years
Operating lease termination option	true
Termination option period	10 years
Operating lease renewal term, description	The Company has options to extend the term of the lease for three additional five-year periods
Operating lease termination option	Company has an option to terminate the lease after 10 years subject to payment of an early termination fee
Lease term							15 years
Area of leased property \| ft²							138,000
Additional Lease Option Rights Exercised (In Square Feet) \| ft²						25,405
Number of additional periods \| Item	3
Additional lease option rights (in square feet) \| ft²	95,000
Base rent	$ 4,700
Annual rent increase percentage	2.50%
Chelsea, Massachusetts \| Manufacturing Facility
Operating Lease Information
Area of leased property \| ft²			95,000
Base rent			$ 1,700
Chelsea, Massachusetts \| Manufacturing Facility \| Civitas Therapeutics
Operating Lease Information
Lease option to extend term	5 years
Area of leased property \| ft²	90,000
Number of additional periods \| Item	2
Base rent	$ 1,600			$ 500
Annual rent increase percentage	2.50%			3.00%
Lease expiration date	Dec. 31, 2025
Waltham, MA \| Office and Laboratory Space
Operating Lease Information
Lease term					10 years
Area of leased property \| ft²					26,000
Base rent					$ 1,100
Minimum
Operating Lease Information
Operating lease remaining lease term	2 years
Operating lease renewal term	5 years
Maximum
Operating Lease Information
Operating lease remaining lease term	8 years
Lease option to extend term	15 years
Termination option period	2 years
Operating lease renewal term	15 years
ASU 2016-02, ''Leases'' Topic 842
Operating Lease Information
ROU assets		$ 28,000
Lease liabilities		$ 35,100

Leases - Schedule of ROU Assets and Lease Liabilities Related to Operating Leases (Details) $ in Thousands	Sep. 30, 2019 USD ($)
Leases [Abstract]
Right-of-use assets	$ 24,675
Current lease liabilities	7,696
Non-current lease liabilities	$ 24,393

Leases - Components of Lease Costs (Details) - USD ($) $ in Thousands	3 Months Ended	9 Months Ended
	Sep. 30, 2019	Sep. 30, 2019
Leases [Abstract]
Operating lease cost	$ 1,776	$ 5,293
Variable lease cost	1,119	3,544
Short-term lease cost	440	1,094
Total lease cost	$ 3,335	$ 9,931

Leases - Schedule of Future Minimum Commitments under all Non-Cancelable Operating Leases (Details) $ in Thousands	Sep. 30, 2019 USD ($)
Leases [Abstract]
2019 (excluding the nine months ended Sep 30, 2019)	$ 1,902
2020	7,746
2021	7,935
2022	9,972
2023	3,043
Later years	7,666
Total lease payments	38,264
Less: Imputed interest	(6,175)
Present value of lease liabilities	$ 32,089

Leases - Summary of Supplemental Cash Flow Information and Non-Cash Activity Related to Operating Leases (Details) $ in Thousands	9 Months Ended
	Sep. 30, 2019 USD ($)
Operating cash flow information:
Cash paid for amounts included in the measurement of lease liabilities	$ 5,605
Non-cash activity:
Right-of-use assets obtained in exchange for lease obligations	$ 770